sr -cic.cytoscape.plugin.util.CICPluginSesionData
L Bookmarkt Ljava/util/HashMap;L GlobEdgq ~ L GlobNodq ~ L Gonavq ~ L Helpnavq ~ L Hidedataq ~ L Interpronavt Ljava/lang/Object;L Metnavq ~ L Pfamnavq ~ L Positionq ~ xpsr java.util.HashMap` F
loadFactorI thresholdxp?@ w t 2sr java.util.Vectorٗ}[; I capacityIncrementI elementCount[ elementDatat [Ljava/lang/Object;xp ur [Ljava.lang.Object;Xs)l xp
ppppppppppxxsq ~ ?@ w t 2sq ~ ?@ `w St PRKN2 (2) PRKN2sr databasemapping.Interaction!2g
I fromIdI idZ intraZ ipfamValI
numMethodsI procI toIdL bdReft Ljava/lang/String;L descriptionq ~ L fromSwissq ~ L intmetexpt Ljava/util/Vector;L procStrq ~ L toSwissq ~ xp 1T 1Tpppsq ~ uq ~
sr databasemapping.IntmetexplK,C
I experimentIdI
interactionIdI methodIdI methodPubmedI
multipleIdI procL bdRefq ~ L descriptionq ~ L
methodDescq ~ L procStrq ~ xp Y t h HPRD t !Staropoli JF et al. (2003) Neuront
two hybridt HPRD sq ~ % t h HPRD t !Staropoli JF et al. (2003) Neuront in vivot HPRD ppppppppxt HPRD pt AURKB (2) PSA3sq ~ b pppsq ~ uq ~
sq ~ % t h HPRD t $Shu F et al. (2003) Mol Cell Biochemt in vivot HPRD sq ~ % t h HPRD t $Shu F et al. (2003) Mol Cell Biochemt in vitrot HPRD ppppppppxt HPRD pt
PSA1 (2) PLK1sq ~ Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt
PSB7 (2) PLK1sq ~ # Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt EGR1 (2) CSK21sq ~ dpppsq ~ uq ~
sq ~ . Y t h HPRD t Jain N et al. (1996) J Biol Chemt
two hybridt HPRD sq ~ . % t h HPRD t Jain N et al. (1996) J Biol Chemt in vivot HPRD ppppppppxt HPRD pt
PSA6 (4) PSA7sq ~ pppsq ~ uq ~
sq ~ S$ ?h Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ?h ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ ?h un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct sq ~ r ?h Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppxt HPRD - IntAct - MINT pt
PSA6 (2) PLK1sq ~ Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt
PSA4 (3) PSA1sq ~ pppsq ~ uq ~
sq ~ S$ ܐ , tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt cosedimentation in solutiont HPRD - IntAct - MINT sq ~ S$ ܐ ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ ܐ un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct pppppppxt HPRD - IntAct - MINT pt TRAF6 (2) PSB5sq ~ T 'pppsq ~ uq ~
sq ~ 3 7t IntAct MINT DIP BioGRID HPRD t )Bouwmeester T et al. (2004) Nat Cell Biolt tandem affinity purificationt %DIP - HPRD - IntAct - MINT - BioGRID sq ~ un t s IntAct t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct ppppppppxt %DIP - HPRD - IntAct - MINT - BioGRID pt
PSA1 (3) PSA2sq ~ pppsq ~ uq ~
sq ~ >P ?o % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P ?o % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ r ?o Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct pppppppxt IntAct - BioGRID pt PSMD6 (2) PSB5sq ~ Q 'pppsq ~ uq ~
sq ~ Y" Y t h HPRD t )Bouwmeester T et al. (2004) Nat Cell Biolt
two hybridt HPRD sq ~ Y" un "t IntAct BioGRID t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct - BioGRID ppppppppxt HPRD - IntAct - BioGRID pt NCOA3 (2) NCOA3sq ~ h hpppsq ~ uq ~
sq ~ 2 % t h HPRD t "Xie W et al. (1999) Mol Endocrinolt in vivot HPRD sq ~ 2 Y t h HPRD t "Xie W et al. (1999) Mol Endocrinolt
two hybridt HPRD ppppppppxt HPRD pt PSMD6 (2) PSB3sq ~ Q %pppsq ~ uq ~
sq ~ ] un t s IntAct t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct sq ~ 9 ] un t n MINT t Qiu XB et al. (2006) EMBO Jt "affinity chromatography technologyt MINT ppppppppxt IntAct - MINT pt
PSB2 (2) PSA1sq ~ pppsq ~ uq ~
sq ~ kT ?q un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ r ?q Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppppxt IntAct pt
PSA3 (5) PSA6sq ~ pppsq ~ uq ~
sq ~ S$ x , t s IntAct t !Apcher GS et al. (2004) FEBS Lettt cosedimentation in solutiont IntAct sq ~ kT x un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ 7 x % 0t BioGRID HPRD t #Gerards WL et al. (1998) J Mol Biolt in vitrot HPRD - BioGRID sq ~ n x ` % t IntAct MINT t Stelzl U et al. (2005) Cellt pull downt IntAct - MINT sq ~ n x ʪ t IntAct MINT t Stelzl U et al. (2005) Cellt two hybrid pooling approacht IntAct - MINT pppppxt HPRD - IntAct - MINT - BioGRID pt
PSA6 (2) PSA1sq ~ pppsq ~ uq ~
sq ~ 3 > Y t h HPRD t "Kleijnen MF et al. (2000) Mol Cellt
two hybridt HPRD sq ~ w0 > Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD pt PSA3 (3) CDN1Asq ~ >pppsq ~ uq ~
sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ 3 % 0t BioGRID HPRD t Touitou R et al. (2001) EMBO Jt in vivot HPRD - BioGRID sq ~ 3 % 0t BioGRID HPRD t Touitou R et al. (2001) EMBO Jt in vitrot HPRD - BioGRID pppppppxt HPRD - BioGRID pt RFPLA (3) PSB1sq ~ (pppsq ~ uq ~
sq ~ ͽ % t d BioGRID t 1Suzumori N et al. (2003) Proc Natl Acad Sci U S At in vivot BioGRID sq ~ ͽ % t d BioGRID t 1Suzumori N et al. (2003) Proc Natl Acad Sci U S At in vitrot BioGRID sq ~ ͽ Y t d BioGRID t 1Suzumori N et al. (2003) Proc Natl Acad Sci U S At
two hybridt BioGRID pppppppxt BioGRID pt
XRN2 (2) PSA3sq ~ @ pppsq ~ uq ~
sq ~ k Y :t IntAct BioGRID BIND HPRD t !Lehner B et al. (2004) Genome Rest
two hybridt BIND - HPRD - IntAct - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt BIND - HPRD - IntAct - BioGRID pt
PSB7 (2) PSA3sq ~ # pppsq ~ uq ~
sq ~ T^ un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct sq ~ 9 T^ un t n MINT t Qiu XB et al. (2006) EMBO Jt "affinity chromatography technologyt MINT ppppppppxt IntAct - MINT pt
PSA3 (2) EGR1sq ~ pppsq ~ uq ~
sq ~ W % 0t BioGRID HPRD t )Bae MH et al. (2002) Biochim Biophys Actat in vivot HPRD - BioGRID sq ~ W Y 0t BioGRID HPRD t )Bae MH et al. (2002) Biochim Biophys Actat
two hybridt HPRD - BioGRID ppppppppxt HPRD - BioGRID pt
PSB1 (2) VINCsq ~ ( @Vpppsq ~ uq ~
sq ~ `
% t m BIND t de Hoog CL et al. (2004) Cellt molecular interactiont BIND sq ~ J
3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt BIND - BioGRID pt
PSA2 (5) PSA7sq ~ pppsq ~ uq ~
sq ~ S$ Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ >P % t l BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P % t l BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ w0 Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD pppppxt HPRD - IntAct - MINT - BioGRID pt NCOA1 (2) GRIP1sq ~ {pppsq ~ uq ~
sq ~
Y t n MINT t Zhang Y et al. (2007) EMBO Jt
two hybridt MINT sq ~
un t n MINT t Zhang Y et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT ppppppppxt MINT pt TRAF6 (2) PSMD6sq ~ T Qpppsq ~ uq ~
sq ~ V 3 t IntAct MINT DIP HPRD t )Bouwmeester T et al. (2004) Nat Cell Biolt tandem affinity purificationt DIP - HPRD - IntAct - MINT sq ~ V un t s IntAct t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct ppppppppxt DIP - HPRD - IntAct - MINT pt
VINC (2) VINCsq ~ @V @Vpppsq ~ uq ~
sq ~ X4
U % t m BIND t Izard T et al. (2004) Naturet molecular interactiont BIND sq ~ J
U 3 t l BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt BIND - BioGRID pt
PSA4 (4) PSA2sq ~ pppsq ~ uq ~
sq ~ S$ ?l Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ?l ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ r ?l Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct sq ~ w0 ?l Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppxt HPRD - IntAct - MINT pt
PSA4 (5) PSA7sq ~ pppsq ~ uq ~
sq ~ S$ ?i un tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt anti bait coimmunoprecipitationt HPRD - IntAct - MINT sq ~ S$ ?i Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ?i ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ r ?i Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct sq ~ 9 ?i un t n MINT t Qiu XB et al. (2006) EMBO Jt "affinity chromatography technologyt MINT pppppxt HPRD - IntAct - MINT pt TRAF6 (2) PRS4sq ~ T Mpppsq ~ uq ~
sq ~ 3 7t IntAct MINT DIP BioGRID HPRD t )Bouwmeester T et al. (2004) Nat Cell Biolt tandem affinity purificationt %DIP - HPRD - IntAct - MINT - BioGRID sq ~ un t s IntAct t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct ppppppppxt %DIP - HPRD - IntAct - MINT - BioGRID pt
PSA5 (2) PSA4sq ~ J pppsq ~ uq ~
sq ~ S$ ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ kT un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct ppppppppxt HPRD - IntAct - MINT pt
PSB9 (3) PSA2sq ~ ) pppsq ~ uq ~
sq ~ >P ' % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P ' % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ kT ' un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct pppppppxt IntAct - BioGRID pt
PSB1 (2) PSB3sq ~ ( %pppsq ~ uq ~
sq ~ kT ? un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ r ? Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppppxt IntAct pt
PSA3 (2) PSA5sq ~ Jpppsq ~ uq ~
sq ~ kT un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ w0 Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD - IntAct pt
PSA7 (2) PSB7sq ~ #pppsq ~ uq ~
sq ~ % un t n MINT t %Dächsel JC et al. (2005) FEBS Lettt anti bait coimmunoprecipitationt MINT sq ~ w0 % Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD - MINT pt
PSB1 (2) PLK1sq ~ ( Epppsq ~ uq ~
sq ~ o ; % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J ; 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt
PSA3 (2) PSA4sq ~ pppsq ~ uq ~
sq ~ S$ ?m ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ r ?m Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppppxt HPRD - IntAct - MINT pt
PSA4 (2) PLK1sq ~ Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt
PSB2 (2) PSB5sq ~ 'pppsq ~ uq ~
sq ~ kT ?~ un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ r ?~ Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppppxt IntAct pt
CCR5 (2) CCR5sq ~ &u &upppsq ~ uq ~
sq ~ 9 % t h HPRD t 'Huttenrauch F et al. (2002) J Biol Chemt in vivot HPRD sq ~ 9 Y t h HPRD t 'Huttenrauch F et al. (2002) J Biol Chemt
two hybridt HPRD ppppppppxt HPRD pt SMAD1 (4) SMAD1sq ~ pppsq ~ uq ~
sq ~ k Y t MINT BIND t "Colland F et al. (2004) Genome Rest
two hybridt BIND - MINT sq ~ % t h HPRD t $Gajavelli S et al. (2004) Exp Neurolt in vivot HPRD sq ~ % t h HPRD t $Gajavelli S et al. (2004) Exp Neurolt in vitrot HPRD sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppxt BIND - HPRD - MINT - BioGRID pt TRAF6 (2) PSA1sq ~ T pppsq ~ uq ~
sq ~ 3 t IntAct MINT t )Bouwmeester T et al. (2004) Nat Cell Biolt tandem affinity purificationt IntAct - MINT sq ~ un t s IntAct t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct ppppppppxt IntAct - MINT pt
PSB2 (2) PSB3sq ~ %pppsq ~ uq ~
sq ~ r ? Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct sq ~ w0 ? Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD - IntAct pt
PSB3 (2) PLK1sq ~ % Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt PSB9 (3) NCOA1sq ~ ) pppsq ~ uq ~
sq ~ R R ` % t n MINT t Zhang H et al. (2006) EMBO Jt pull downt MINT sq ~ R R Y t n MINT t Zhang H et al. (2006) EMBO Jt
two hybridt MINT sq ~ R R un t n MINT t Zhang H et al. (2006) EMBO Jt anti bait coimmunoprecipitationt MINT pppppppxt MINT pt PSA2 (2) PSB10sq ~ pppsq ~ uq ~
sq ~ >P Z % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P Z % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt PSB9 (3) NCOA3sq ~ ) hpppsq ~ uq ~
sq ~ R Q ` % t n MINT t Zhang H et al. (2006) EMBO Jt pull downt MINT sq ~ R Q Y t n MINT t Zhang H et al. (2006) EMBO Jt
two hybridt MINT sq ~ R Q un t n MINT t Zhang H et al. (2006) EMBO Jt anti bait coimmunoprecipitationt MINT pppppppxt MINT pt TRAF6 (2) TRAF6sq ~ T Tpppsq ~ uq ~
sq ~ 2 Y t h HPRD t .Naito A et al. (2002) Proc Natl Acad Sci U S At
two hybridt HPRD sq ~ I % t m BIND t Sun L et al. (2004) Mol Cellt molecular interactiont BIND ppppppppxt BIND - HPRD pt
PSA2 (2) PSB8sq ~ @pppsq ~ uq ~
sq ~ >P _ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P _ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt
PSA7 (2) PSA7sq ~ pppsq ~ uq ~
sq ~ S$ Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT ppppppppxt HPRD - IntAct - MINT pt PSA3 (2) CSK21sq ~ dpppsq ~ uq ~
sq ~ | Y t h HPRD t (Castaño JG et al. (1996) Biochemistryt
two hybridt HPRD sq ~ | % t h HPRD t (Castaño JG et al. (1996) Biochemistryt in vivot HPRD ppppppppxt HPRD pt
PSA6 (2) PSB7sq ~ #pppsq ~ uq ~
sq ~ kT un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ w0 Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD - IntAct pt
PSA2 (2) PSB6sq ~ &pppsq ~ uq ~
sq ~ >P \ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P \ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt
PSA7 (2) PRS4sq ~ Mpppsq ~ uq ~
sq ~ Z % 0t BioGRID HPRD t 6Hartmann-Petersen R et al. (2001) Arch Biochem Biophyst in vitrot HPRD - BioGRID sq ~ Z Y 0t BioGRID HPRD t 6Hartmann-Petersen R et al. (2001) Arch Biochem Biophyst
two hybridt HPRD - BioGRID ppppppppxt HPRD - BioGRID pt
PSA2 (2) PSB2sq ~ pppsq ~ uq ~
sq ~ >P 9 % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P 9 % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt
PSB1 (2) PAI2sq ~ ( pppsq ~ uq ~
sq ~ J s % t h HPRD t 7Fan J et al. (2004) Acta Biochim Biophys Sin (Shanghai)t in vivot HPRD sq ~ J s % t h HPRD t 7Fan J et al. (2004) Acta Biochim Biophys Sin (Shanghai)t in vitrot HPRD ppppppppxt HPRD pt PSA2 (2) KIF3Csq ~ d0pppsq ~ uq ~
sq ~ >P [ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P [ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt PSA3 (4) CRYABsq ~ Upppsq ~ uq ~
sq ~ t R % 0t BioGRID HPRD t -Boelens WC et al. (2001) Biochim Biophys Actat in vivot HPRD - BioGRID sq ~ t R % 0t BioGRID HPRD t -Boelens WC et al. (2001) Biochim Biophys Actat in vitrot HPRD - BioGRID sq ~ t R Y 0t BioGRID HPRD t -Boelens WC et al. (2001) Biochim Biophys Actat
two hybridt HPRD - BioGRID sq ~ J R 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppxt HPRD - BioGRID pt PRKN2 (2) VINCsq ~ 1T @Vpppsq ~ uq ~
sq ~ `
q % t m BIND t de Hoog CL et al. (2004) Cellt molecular interactiont BIND sq ~ J
q 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt BIND - BioGRID pt
PSB3 (2) PSB4sq ~ % Qpppsq ~ uq ~
sq ~ 2 R 3 t s IntAct t Koch HB et al. (2007) Cell Cyclet tandem affinity purificationt IntAct sq ~ w0 R Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD - IntAct pt
PSA3 (2) PSB5sq ~ 'pppsq ~ uq ~
sq ~ ?| un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct sq ~ r ?| Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppppxt IntAct pt
PSB8 (2) PSB8sq ~ @ @pppsq ~ uq ~
sq ~ = 1 Y t h HPRD t #Früh K et al. (1992) J Biol Chemt
two hybridt HPRD sq ~ = 1 % t h HPRD t #Früh K et al. (1992) J Biol Chemt in vivot HPRD ppppppppxt HPRD pt
PSB8 (2) PSB9sq ~ @ )pppsq ~ uq ~
sq ~ kT ' un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ w0 ' Y t h HPRD t 5Kristensen P et al. (1994) Biochem Biophys Res Communt
two hybridt HPRD ppppppppxt HPRD - IntAct pt
PSA2 (4) PSB4sq ~ Qpppsq ~ uq ~
sq ~ >P % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ kT un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ 9 un t n MINT t Qiu XB et al. (2006) EMBO Jt "affinity chromatography technologyt MINT ppppppxt IntAct - MINT - BioGRID pt
PSB4 (2) PLK1sq ~ Q Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt
PSA2 (2) GDITsq ~ {pppsq ~ uq ~
sq ~ >P ] % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P ] % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt
PSA2 (4) PSB7sq ~ #pppsq ~ uq ~
sq ~ ' un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct sq ~ >P ' % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P ' % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ kT ' un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct ppppppxt IntAct - BioGRID pt PSB9 (3) GRIP1sq ~ ) {pppsq ~ uq ~
sq ~ R P ` % t n MINT t Zhang H et al. (2006) EMBO Jt pull downt MINT sq ~ R P Y t n MINT t Zhang H et al. (2006) EMBO Jt
two hybridt MINT sq ~ R P un t n MINT t Zhang H et al. (2006) EMBO Jt anti bait coimmunoprecipitationt MINT pppppppxt MINT pt PSA7 (2) HIF1Asq ~ pppsq ~ uq ~
sq ~ ` % 4tB MINT BioGRID HPRD t Cho S et al. (2001) FEBS Lettt pull downt HPRD - MINT - BioGRID sq ~ un 4tB MINT BioGRID HPRD t Cho S et al. (2001) FEBS Lettt coimmunoprecipitationt HPRD - MINT - BioGRID ppppppppxt HPRD - MINT - BioGRID pt SMAD1 (4) PSB4sq ~ Qpppsq ~ uq ~
sq ~ k Y t MINT BIND t "Colland F et al. (2004) Genome Rest
two hybridt BIND - MINT sq ~ { % 0t BioGRID HPRD t !Lin Y et al. (2002) BMC Cell Biolt in vivot HPRD - BioGRID sq ~ { Y 0t BioGRID HPRD t !Lin Y et al. (2002) BMC Cell Biolt
two hybridt HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppxt BIND - HPRD - MINT - BioGRID pt
PSB3 (3) PSA2sq ~ % pppsq ~ uq ~
sq ~ T] un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct sq ~ >P T] % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P T] % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID pppppppxt IntAct - BioGRID pt
PSA3 (2) PLK1sq ~ Epppsq ~ uq ~
sq ~ o % 0t BioGRID HPRD t 'Feng Y et al. (2001) Cell Growth Differt in vivot HPRD - BioGRID sq ~ J 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt
PSA7 (4) PSA1sq ~ pppsq ~ uq ~
sq ~ S$ ?j , tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt cosedimentation in solutiont HPRD - IntAct - MINT sq ~ S$ ?j Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ?j ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ r ?j Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppxt HPRD - IntAct - MINT pt
PSA7 (4) PSA3sq ~ pppsq ~ uq ~
sq ~ S$ ܑ , tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt cosedimentation in solutiont HPRD - IntAct - MINT sq ~ S$ ܑ Y tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt
two hybridt HPRD - IntAct - MINT sq ~ S$ ܑ ` % tI IntAct MINT HPRD t !Apcher GS et al. (2004) FEBS Lettt pull downt HPRD - IntAct - MINT sq ~ 2 ܑ 3 t s IntAct t Koch HB et al. (2007) Cell Cyclet tandem affinity purificationt IntAct ppppppxt HPRD - IntAct - MINT pt
PSA4 (3) PSB1sq ~ (pppsq ~ uq ~
sq ~ un t s IntAct t ,Claverol S et al. (2002) Mol Cell Proteomicst "affinity chromatography technologyt IntAct sq ~ kT un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct sq ~ 2 3 t s IntAct t Koch HB et al. (2007) Cell Cyclet tandem affinity purificationt IntAct pppppppxt IntAct pt PRKN2 (3) PSA7sq ~ 1T pppsq ~ uq ~
sq ~ $ ʪ t n MINT t %Dächsel JC et al. (2005) FEBS Lettt two hybrid pooling approacht MINT sq ~ $ un t n MINT t %Dächsel JC et al. (2005) FEBS Lettt anti tag coimmunoprecipitationt MINT sq ~ $ un t n MINT t %Dächsel JC et al. (2005) FEBS Lettt anti bait coimmunoprecipitationt MINT pppppppxt MINT pt NCOA1 (2) NCOA1sq ~ pppsq ~ uq ~
sq ~ Y t h HPRD t !Makishima M et al. (1999) Sciencet
two hybridt HPRD sq ~ % t h HPRD t !Makishima M et al. (1999) Sciencet in vivot HPRD ppppppppxt HPRD pt
PSB5 (3) PSA2sq ~ ' pppsq ~ uq ~
sq ~ >P % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ kT un t s IntAct t "Froment C et al. (2005) Proteomicst anti bait coimmunoprecipitationt IntAct pppppppxt IntAct - BioGRID pt
PSA5 (2) CCR5sq ~ J &upppsq ~ uq ~
sq ~ HPRD t &Fernandis AZ et al. (2002) J Biol Chemt
two hybridt HPRD sq ~ HPRD t &Fernandis AZ et al. (2002) J Biol Chemt in vitrot HPRD ppppppppxt HPRD pt
PSA2 (4) PSA6sq ~ pppsq ~ uq ~
sq ~ S$ ?k , t s IntAct t !Apcher GS et al. (2004) FEBS Lettt cosedimentation in solutiont IntAct sq ~ >P ?k % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P ?k % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID sq ~ r ?k Y t s IntAct t 3Jayarapu K et al. (2004) Biochem Biophys Res Communt
two hybridt IntAct ppppppxt IntAct - BioGRID pt PSMD6 (2) PSA6sq ~ Q pppsq ~ uq ~
sq ~ W un t s IntAct t $Ewing RM et al. (2007) Mol Syst Biolt anti bait coimmunoprecipitationt IntAct sq ~ 9 W un t n MINT t Qiu XB et al. (2006) EMBO Jt "affinity chromatography technologyt MINT ppppppppxt IntAct - MINT pt
PSA2 (2) PSB1sq ~ (pppsq ~ uq ~
sq ~ >P ^ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vivot BioGRID sq ~ >P ^ % t c BioGRID t 'Elenich LA et al. (1999) Immunogeneticst in vitrot BioGRID ppppppppxt BioGRID pt NCOA3 (2) GRIP1sq ~ h {pppsq ~ uq ~
sq ~
un t n MINT t Zhang Y et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT sq ~
% t n MINT t Zhang Y et al. (2007) EMBO Jt fluorescence microscopyt MINT ppppppppxt MINT pt HIF1A (2) NCOA1sq ~ pppsq ~ uq ~
sq ~ % 0t BioGRID HPRD t %Carrero P et al. (2000) Mol Cell Biolt in vitrot HPRD - BioGRID sq ~ % 0t BioGRID HPRD t %Carrero P et al. (2000) Mol Cell Biolt in vivot HPRD - BioGRID ppppppppxt HPRD - BioGRID pxxsq ~ ?@ w q ~
sq ~ ?@ 0w @ 't PSA3sr databasemapping.ProteinuWSR D clustercoefI connectcoefI idI numintI taxonIdL descriptionq ~ L ensq ~ L gensq ~ L goStatsq ~ L gosq ~ L interq ~ L pfamsq ~ L swissIdq ~ L swissNameq ~ L synonimsq ~ L taxonNameq ~ xp?؝ ( ( %t Proteasome subunit alpha type-3sq ~ uq ~
sr databasemapping.UniEnQW)U I idL ensIdq ~ xp t ENSG00000100567pppppppppxsq ~ uq ~
sr databasemapping.UniGennGs+w I idC typeL genIdq ~ xp t PSMA3sq ~ t PSC8ppppppppxsq ~ buq ~
sr databasemapping.GoStat> I goIdZ knowI numI proteinIdI rootL descriptionq ~ xp t P:signal transductionsq ~ [ t P:cell proliferationsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ t P:RNA splicingsq ~ 9 t P:protein foldingsq ~ t P:protein polyubiquitinationsq ~ C t P:response to oxidative stresssq ~ + t P:immune responsesq ~ t P:cell cycle arrestsq ~ t P:mitosissq ~ t P:membrane fusionsq ~ / t P:humoral immune responsesq ~ t P:muscle contractionsq ~ t P:anti-apoptosissq ~ t !P:cellular copper ion homeostasissq ~ t +P:NLS-bearing substrate import into nucleussq ~ n t P:ATP-dependent proteolysissq ~ D t $P:protein amino acid phosphorylationsq ~ . t (P:regulation of translational initiationsq ~ t P:RNA catabolic processsq ~ t P:RNA processingsq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t 0P:cell surface receptor linked signal transdu...sq ~ ƶ t *P:positive regulation of T cell activationsq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ u t &P:positive regulation of transcriptionsq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ ~ t 0P:positive regulation of proteasomal ubiquiti...sq ~ ~ t 0P:negative regulation of intracellular transportsq ~ z t /P:positive regulation of protein ubiquitinationsq ~ ws t 0P:ubiquitin-dependent SMAD protein catabolic ...sq ~ > t
P:cell growthsq ~ = t P:glucose transportsq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ ] t +P:negative regulation of cell proliferationsq ~ t P:metabolic processsq ~ t $P:central nervous system developmentsq ~ s t P:spermatogenesissq ~ k t &P:multicellular organismal developmentsq ~ R t )P:activation of NF-kappaB-inducing kinasesq ~ ɔ t P:protein maturationsq ~ r t 0P:G1-specific transcription in mitotic cell c...sq ~ t 'P:DNA catabolic process, exonucleolyticsq ~ J t .P:regulation of progression through cell cyclesq ~ t 0P:transmembrane receptor protein tyrosine kin...sq ~ O t 0P:regulation of cyclin-dependent protein kina...sq ~
t 0P:positive regulation of T cell cytokine prod...sq ~ | t 0P:regulation of glucocorticoid metabolic processsq ~ z t 0P:negative regulation of transcription from R...sq ~ t F:protein bindingsq ~ t t F:transcription factor activitysq ~ t #F:ubiquitin-protein ligase activitysq ~ t
F:RNA bindingsq ~ t F:SMAD bindingsq ~ t F:5'-3' exoribonuclease activitysq ~ t "F:threonine endopeptidase activitysq ~ } t F:protein N-terminus bindingsq ~ t $F:transcription coactivator activitysq ~ A t F:ATPase activitysq ~ u t (F:Hsp70/Hsc70 protein inhibitor activitysq ~ wP t F:Hsp70 protein bindingsq ~ x t 0F:specific RNA polymerase II transcription fa...sq ~ t 0F:cyclin-dependent protein kinase inhibitor a...sq ~ x t F:TPR domain bindingsq ~ ʧ t F:Hsp90 protein bindingsq ~ O t F:endopeptidase activitysq ~ K t F:poly-glutamine tract bindingsq ~ J t F:protein kinase CK2 activitysq ~ Q t F:microtubule bindingsq ~ t F:copper ion bindingsq ~ l t F:SNAP receptor activitysq ~ ; t F:hormone activitysq ~ t !F:growth hormone receptor bindingsq ~ t )F:tumor necrosis factor receptor activitysq ~ w t F:protein binding, bridgingsq ~ t F:receptor activitysq ~ t F:signal transducer activitysq ~ B t *F:protein serine/threonine kinase activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ 1 t
C:spliceosomesq ~ t +C:proteasome core complex (sensu Eukaryota)sq ~ wD t )C:small nuclear ribonucleoprotein complexsq ~ A t C:lipid raftsq ~ z t &C:ubiquitin conjugating enzyme complexsq ~ t C:Bcl3/NF-kappaB2 complexsq ~ M t C:extrinsic to membranesq ~ t
C:polysomesq ~ t 0C:proteasome regulatory particle (sensu Eukar...sq ~ t C:cytosolsq ~ t C:centrosomesq ~ t C:endoplasmic reticulumsq ~ t C:autophagic vacuolesq ~ b t C:nucleolussq ~ t C:integral to plasma membranesq ~ t C:Golgi apparatussq ~ t C:plasma membraneppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sr databasemapping.UniGo2u|- I idI rootL descriptionq ~ L goIdq ~ xp t F:protein bindingt 5515sq ~ t C:cytoplasmt 5737sq ~ t C:nucleust 5634sq ~ t &C:proteasome complex (sensu Eukaryota)t 502ppppppxsq ~ uq ~
sr databasemapping.UniIntere I idL interIdq ~ L nameq ~ xp t IPR001353t Proteasome_A_Bsq ~ t IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sr databasemapping.UniPfamZ2ߝS I idL nameq ~ L pfamIdq ~ xp t
Proteasomet PF00227pppppppppxt P25788t
PSA3_HUMANsq ~ uq ~
sr databasemapping.UniSynonimSZ- I proteinIdL descriptionq ~ xp t Proteasome component C8sq ~ t Macropain subunit C8sq ~ t /Multicatalytic endopeptidase complex subunit C8pppppppxt Homo sapienst PSA2sq ~?bb # # %t Proteasome subunit alpha type-2sq ~ uq ~
sq ~ t ENSG00000106588pppppppppxsq ~ uq ~
sq ~ t PSMA2sq ~ t PSC3ppppppppxsq ~ [uq ~
sq ~ J t .P:regulation of progression through cell cyclesq ~ t P:anti-apoptosissq ~ & t P:response to stresssq ~ ] t +P:negative regulation of cell proliferationsq ~ t P:cell adhesionsq ~ t P:signal transductionsq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ D t $P:protein amino acid phosphorylationsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ t P:base-excision repairsq ~ t P:DNA repairsq ~ t P:DNA dealkylationsq ~ b t !P:Rho protein signal transductionsq ~ uP t P:lamellipodium biogenesissq ~ ! t P:apical junction assemblysq ~ v t 'P:negative regulation of cell migrationsq ~ t ,P:regulation of transcription, DNA-dependentsq ~ . t (P:regulation of translational initiationsq ~ + t P:immune responsesq ~ V t
P:JNK cascadesq ~ R t )P:activation of NF-kappaB-inducing kinasesq ~ t &P:negative regulation of cell adhesionsq ~ / t P:humoral immune responsesq ~ # t .P:nucleoside triphosphate biosynthetic processsq ~ l t
P:proteolysissq ~ E t 0P:negative regulation of protein kinase activitysq ~
t 0P:positive regulation of T cell cytokine prod...sq ~ t P:response to drugsq ~ M t P:DNA damage checkpointsq ~ r t %P:regulation of epidermis developmentsq ~ t (P:protein amino acid autophosphorylationsq ~ n t P:ATP-dependent proteolysissq ~ t 0P:positive regulation of epithelial cell prol...sq ~ ƅ t P:protein stabilizationsq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ t P:cell morphogenesissq ~ ƶ t *P:positive regulation of T cell activationsq ~ t P:protein polyubiquitinationsq ~ z t 0P:negative regulation of transcription from R...sq ~ 2 t 0P:positive regulation of keratinocyte differe...sq ~ t -P:positive regulation of cell differentiationsq ~ : t "P:negative regulation of apoptosissq ~ t )P:negative regulation of caspase activitysq ~ @ t P:protein ubiquitinationsq ~ t F:protein bindingsq ~ t
F:ATP bindingsq ~ 2 t F:identical protein bindingsq ~ t
F:RNA bindingsq ~ O t F:endopeptidase activitysq ~ B t *F:protein serine/threonine kinase activitysq ~ w t F:protein binding, bridgingsq ~ @k t F:oxidoreductase activitysq ~ A t F:ATPase activitysq ~ M t F:kinase bindingsq ~ NJ t F:unfolded protein bindingsq ~ t F:caspase inhibitor activitysq ~ t F:alpha-catenin bindingsq ~ t F:transcription factor bindingsq ~ t )F:Rho GDP-dissociation inhibitor activitysq ~ t F:calcium ion bindingsq ~ ` t $F:NF-kappaB-inducing kinase activitysq ~ t (F:nucleoside diphosphate kinase activitysq ~ t F:signal transducer activitysq ~ t t F:transcription factor activitysq ~ d t F:damaged DNA bindingsq ~ t F:motor activitysq ~ t #F:ubiquitin-protein ligase activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ t C:protein complexsq ~ i t C:cytoplasmsq ~ t +C:proteasome core complex (sensu Eukaryota)sq ~ W t !C:perinuclear region of cytoplasmsq ~ t C:rufflesq ~ t
C:nucleoplasmsq ~ t C:kinesin complexsq ~ t C:costameresq ~ ' t C:cell surfacesq ~ > t $C:cytoplasmic membrane-bound vesiclesq ~ % t C:focal adhesionsq ~ t C:intercellular junctionsq ~ t C:cytoskeletonsq ~ t
C:polysomesq ~ uK t C:lamellipodiumsq ~ t C:cytosolsq ~ t #C:ER-Golgi intermediate compartmentsq ~ t C:endoplasmic reticulum lumensq ~ t C:endoplasmic reticulumsq ~ t C:autophagic vacuolesq ~ k t C:mitochondrionsq ~ u t ,C:integral to endoplasmic reticulum membranepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t F:protein bindingt 5515sq ~ t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ t IPR001353t Proteasome_A_Bsq ~ t IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt P25787t
PSA2_HUMANsq ~ uq ~
sq ~ t Proteasome component C3sq ~ t Macropain subunit C3sq ~ t /Multicatalytic endopeptidase complex subunit C3pppppppxt Homo sapienst PSA5sq ~??? J %t Proteasome subunit alpha type-5sq ~ uq ~
sq ~ Jt ENSG00000143106pppppppppxsq ~ uq ~
sq ~ J t PSMA5pppppppppxsq ~ 6uq ~
Psq ~ ʩ J t 0P:regulation of mitochondrial membrane potentialsq ~ * J t P:inflammatory responsesq ~ J t P:anti-apoptosissq ~ J t P:apoptosissq ~ J t P:cellular iron ion homeostasissq ~ J t 0P:oxygen and reactive oxygen species metaboli...sq ~ o J t /P:ubiquitin-dependent protein catabolic processsq ~ = J t P:protein complex assemblysq ~ J t P:DNA repairsq ~ + J t P:immune responsesq ~ / J t P:humoral immune responsesq ~ 8 J t P:cellular defense responsesq ~ J t P:ATP metabolic processsq ~ J t P:cellular respirationsq ~ J t 0P:cytoplasmic sequestering of transcription f...sq ~ [ J t P:cell proliferationsq ~ c J t P:cell-cell signalingsq ~ $ J t 0P:elevation of cytosolic calcium ion concentr...sq ~ J t 0P:G-protein coupled receptor protein signalin...sq ~ J t P:mitosissq ~ J t 0P:mitochondrial electron transport, NADH to u...sq ~ J t P:chemotaxissq ~ J J t .P:regulation of progression through cell cyclesq ~ J t -P:meiotic spindle organization and biogenesissq ~ w J t P:leukocyte chemotaxissq ~
J t F:protein bindingsq ~ S J t +F:phosphoinositide phospholipase C activitysq ~ O J t F:endopeptidase activitysq ~ J t F:actin bindingsq ~ J t $F:transcription coactivator activitysq ~ J t *F:NADH dehydrogenase (ubiquinone) activitysq ~ : J t F:coreceptor activitysq ~ @m J t !F:C-C chemokine receptor activitysq ~ J t F:receptor antagonist activitysq ~ B J t *F:protein serine/threonine kinase activitysq ~ P J t (F:structural constituent of cytoskeletonsq ~ J t $F:transcription corepressor activitysq ~ J t &C:proteasome complex (sensu Eukaryota)sq ~ J t C:nucleussq ~ i J t C:cytoplasmsq ~ J t C:centrosomesq ~ J t C:condensed nuclear chromosomesq ~ J t C:integral to plasma membranesq ~ J t +C:proteasome core complex (sensu Eukaryota)sq ~ W J t !C:perinuclear region of cytoplasmsq ~ J t
C:endosomesq ~ ~ J t #C:mitochondrial intermembrane spacesq ~ & J t "C:external side of plasma membranesq ~ J t C:gamma-tubulin complexsq ~ s J t +C:mitochondrial respiratory chain complex Isq ~ k J t C:mitochondrionsq ~ J t C:extracellular regionsq ~ J t C:spindle pole bodysq ~ J t C:polar microtubuleppppppppppppppppppppppppppxsq ~ uq ~
sq ~ J t &C:proteasome complex (sensu Eukaryota)t 502pppppppppxsq ~ uq ~
sq ~ Jt IPR001353t Proteasome_A_Bsq ~ Jt IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sq ~ Jt
Proteasomet PF00227pppppppppxt P28066t
PSA5_HUMANsq ~ uq ~
sq ~ Jt Proteasome zeta chainsq ~ Jt Macropain zeta chainsq ~ Jt /Multicatalytic endopeptidase complex zeta chainpppppppxt Homo sapienst PSA4sq ~?oo
%t Proteasome subunit alpha type-4sq ~ uq ~
sq ~ t ENSG00000041357pppppppppxsq ~ uq ~
sq ~ t PSMA4sq ~ t PSC9ppppppppxsq ~ #uq ~
(sq ~ J t .P:regulation of progression through cell cyclesq ~ . t (P:regulation of translational initiationsq ~ D t $P:protein amino acid phosphorylationsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ t P:anti-apoptosissq ~ t P:cell motilitysq ~ . t *P:complement activation, classical pathwaysq ~ J t P:response to unfolded proteinsq ~ t P:mitosissq ~ t P:signal transductionsq ~ R t )P:activation of NF-kappaB-inducing kinasesq ~ [ t P:cell proliferationsq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ ƶ t *P:positive regulation of T cell activationsq ~ t P:protein polyubiquitinationsq ~
t 0P:positive regulation of T cell cytokine prod...sq ~ t F:protein bindingsq ~ t
F:RNA bindingsq ~ J t F:protein kinase CK2 activitysq ~ O t F:endopeptidase activitysq ~ B t *F:protein serine/threonine kinase activitysq ~ } t F:protein N-terminus bindingsq ~ t #F:ubiquitin-protein ligase activitysq ~ t F:signal transducer activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ ' t C:cell surfacesq ~ t +C:proteasome core complex (sensu Eukaryota)sq ~ t C:extracellular spacesq ~ t C:plasma membranesq ~ t C:centrosomesq ~ t
C:polysomesq ~ t C:cytoskeletonpppppxsq ~ uq ~
sq ~ t &C:proteasome complex (sensu Eukaryota)t 502pppppppppxsq ~ uq ~
sq ~ t IPR001353t Proteasome_A_Bsq ~ t IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt P25789t
PSA4_HUMANsq ~ uq ~
sq ~ t Proteasome component C9sq ~ t Macropain subunit C9sq ~ t /Multicatalytic endopeptidase complex subunit C9sq ~ t Proteasome subunit Lppppppxt Homo sapienst GRIP1sq ~? { %t (Glutamate receptor-interacting protein 1sq ~ uq ~
sq ~ {t ENSG00000155974pppppppppxsq ~ uq ~
sq ~ { t GRIP1pppppppppxsq ~ ;uq ~
Psq ~ { t P:signal transductionsq ~ c { t P:cell-cell signalingsq ~ { t /P:transcription from RNA polymerase II promotersq ~ d { t P:synaptic transmissionsq ~ E { t 0P:positive regulation of transcription, DNA-d...sq ~ w9 { t %P:androgen receptor signaling pathwaysq ~ { t 0P:negative regulation of adenylate cyclase ac...sq ~ { t 0P:G-protein coupled receptor protein signalin...sq ~ { t P:cell adhesionsq ~ { t P:muscle contractionsq ~ { t P:transportsq ~ D { t $P:protein amino acid phosphorylationsq ~ { t ,P:regulation of transcription, DNA-dependentsq ~ w8 { t %P:estrogen receptor signaling pathwaysq ~ J { t !P:intracellular signaling cascadesq ~ | { t P:sex differentiationsq ~ > { t
P:cell growthsq ~ x { t P:prostate gland developmentsq ~ { t P:transcription, DNA-dependentsq ~ % { t $P:anatomical structure morphogenesissq ~ [ { t P:cell proliferationsq ~ { t P:female pregnancysq ~ } { t F:protein N-terminus bindingsq ~ { t F:androgen receptor bindingsq ~ { t F:ephrin receptor bindingsq ~ { t $F:transcription coactivator activitysq ~ { t F:protein bindingsq ~ t { t F:transcription factor activitysq ~ { t "F:glucocorticoid receptor activitysq ~ { t F:androgen receptor activitysq ~ B { t *F:protein serine/threonine kinase activitysq ~ ; { t /F:kainate selective glutamate receptor activitysq ~ 2 { t $F:histone acetyltransferase activitysq ~ { t F:actin bindingsq ~ { t !F:transcription cofactor activitysq ~ v { t *F:nitric-oxide synthase regulator activitysq ~ vL { t F:estrogen receptor activitysq ~ L { t 0F:receptor signaling protein tyrosine kinase ...sq ~ { t F:neuropeptide receptor activitysq ~ { t 0F:metabotropic glutamate, GABA-B-like recepto...sq ~ { t
F:ATP bindingsq ~ { t F:protein dimerization activitysq ~ v { t "F:thyroid hormone receptor bindingsq ~ v { t 0F:RNA polymerase II transcription factor acti...sq ~ y { t F:androgen bindingsq ~ { t 0F:receptor signaling protein tyrosine phospha...sq ~ k { t 0F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole ...sq ~ { t C:integral to plasma membranesq ~ { t C:nucleussq ~ { t C:synapsesq ~ @ { t C:chromatin remodeling complexsq ~ ' { t C:cell surfacesq ~ { t &C:proteasome complex (sensu Eukaryota)sq ~ { t C:intracellularsq ~ { t C:soluble fractionsq ~ i { t C:cytoplasmsq ~ { t C:mitochondrial matrixsq ~ { t C:plasma membranesq ~ > { t
C:membranepppppppppppppppppppppxsq ~ uq ~
sq ~ { t %P:androgen receptor signaling pathwayt 30521sq ~ { t 0P:positive regulation of transcription, DNA-d...t 45893sq ~ { t F:androgen receptor bindingt 50681sq ~ { t .F:receptor signaling complex scaffold activityt 30159sq ~ { t $F:transcription coactivator activityt 3713pppppxsq ~ uq ~
sq ~ {t IPR001478t PDZpppppppppxsq ~ uq ~
sq ~ {t PDZt PF00595pppppppppxt Q9Y3R0t GRIP1_HUMANsq ~ uq ~
sq ~ {t
GRIP1 proteinpppppppppxt Homo sapienst PSA1sq ~?S_ 0 0 %t Proteasome subunit alpha type-1sq ~ uq ~
sq ~ t ENSG00000129084pppppppppxsq ~ uq ~
sq ~ t PSMA1sq ~ t PROS30sq ~ t PSC2pppppppxsq ~ Kuq ~
Psq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ D t $P:protein amino acid phosphorylationsq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ t P:signal transductionsq ~ t /P:transcription from RNA polymerase II promotersq ~ * t P:inflammatory responsesq ~ & t P:response to stresssq ~ n t P:ATP-dependent proteolysissq ~ E t 0P:negative regulation of protein kinase activitysq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t P:mitotic recombinationsq ~ t P:DNA dealkylationsq ~ t P:base-excision repairsq ~ t t P:DNA replicationsq ~ + t P:immune responsesq ~ / t P:humoral immune responsesq ~ t P:cell cyclesq ~ t (P:protein amino acid autophosphorylationsq ~ uT t 0P:actin cytoskeleton organization and biogenesissq ~ > t P:viral reproductionsq ~ !` t P:epidermis developmentsq ~ [ t P:cell proliferationsq ~ O t
P:circulationsq ~ t P:brain developmentsq ~ [ t P:JAK-STAT cascadesq ~ V t
P:JNK cascadesq ~ R t )P:activation of NF-kappaB-inducing kinasesq ~ t P:meiotic recombinationsq ~ t P:mitosissq ~ W t P:carbohydrate metabolic processsq ~ J t .P:regulation of progression through cell cyclesq ~ t P:cell motilitysq ~
t 0P:positive regulation of T cell cytokine prod...sq ~ t P:protein polyubiquitinationsq ~ ƶ t *P:positive regulation of T cell activationsq ~ t F:protein bindingsq ~ 2 t F:identical protein bindingsq ~ t
F:ATP bindingsq ~ P t (F:structural constituent of cytoskeletonsq ~ B t *F:protein serine/threonine kinase activitysq ~ t t F:transcription factor activitysq ~ O t F:endopeptidase activitysq ~ t F:actin bindingsq ~ t F:RNA helicase activitysq ~ { t F:GABA receptor bindingsq ~ t $F:transcription coactivator activitysq ~ t !F:transcription cofactor activitysq ~ g t F:beta-tubulin bindingsq ~ t
F:RNA bindingsq ~ @ t "F:transcription repressor activitysq ~ ^ t F:DNA helicase activitysq ~ d t F:damaged DNA bindingsq ~ a t *F:isocitrate dehydrogenase (NAD+) activitysq ~ ` t $F:NF-kappaB-inducing kinase activitysq ~ t #F:ubiquitin-protein ligase activitysq ~ t F:signal transducer activitysq ~ t F:receptor activitysq ~ N t F:structural molecule activitysq ~ A t F:ATPase activitysq ~ t F:phosphatidylinositol bindingsq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:intermediate filamentsq ~ t +C:proteasome core complex (sensu Eukaryota)sq ~ t C:autophagic vacuolesq ~ t C:cytoskeletonsq ~ t C:plasma membranesq ~ t
C:nucleoplasmsq ~ t
C:spectrinsq ~ t 0C:proteasome regulatory particle (sensu Eukar...sq ~ t C:centrosomesq ~ k t C:mitochondrionsq ~ t C:protein complexpppppxsq ~ uq ~
sq ~ t
F:RNA bindingt 3723sq ~ t C:nucleust 5634sq ~ t
C:polysomet 5844sq ~ t &C:proteasome complex (sensu Eukaryota)t 502ppppppxsq ~ uq ~
sq ~ t IPR001353t Proteasome_A_Bsq ~ t IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt P25786t
PSA1_HUMANsq ~ uq ~
sq ~ t Proteasome component C2sq ~ t Macropain subunit C2sq ~ t /Multicatalytic endopeptidase complex subunit C2sq ~ t Proteasome nu chainsq ~ t 30 kDa prosomal proteinsq ~ t PROS-30ppppxt Homo sapienst RFPLAsq ~ %t Ret finger protein-like 4Asq ~ uq ~
sq ~ t ENSG00000187574pppppppppxsq ~ uq ~
sq ~ t RFPL4Asq ~ t RFPL4sq ~ t RNF210pppppppxsq ~ uq ~
sq ~ t P:postreplication repairsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ t F:protein bindingsq ~ t &C:proteasome complex (sensu Eukaryota)ppppppxpsq ~ uq ~
sq ~ t IPR001870t B302sq ~ t IPR003879t Butyrophylinsq ~ t IPR006574t PRYsq ~ t IPR003877t SPRY_rcptsq ~ t IPR001841t Znf_RINGpppppxsq ~ uq ~
sq ~ t SPRYt PF00622pppppppppxt A6NLU0t RFPLA_HUMANsq ~ uq ~
sq ~ t RING finger protein 210pppppppppxt Homo sapienst GDITsq ~?aa { %t Rho GDP-dissociation inhibitor 3sq ~ uq ~
sq ~ {t ENSG00000206156pppppppppxsq ~ uq ~
sq ~ { t ARHGDIGpppppppppxsq ~ 'uq ~
(sq ~ b { t !P:Rho protein signal transductionsq ~ uT { t 0P:actin cytoskeleton organization and biogenesissq ~ { t P:cell adhesionsq ~ J { t .P:regulation of progression through cell cyclesq ~ uP { t P:lamellipodium biogenesissq ~ uY { t P:actin filament polymerizationsq ~ v { t P:T cell differentiationsq ~ v { t P:macrophage differentiationsq ~ z* { t /P:positive regulation of pseudopodium formationsq ~ ze { t 0P:negative regulation of protein complex asse...sq ~ {) { t $P:ruffle organization and biogenesissq ~ { t 0P:positive regulation of Rho protein signal t...sq ~ j { t 0P:positive regulation of NF-kappaB import int...sq ~ s { t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ t { t 0P:negative regulation of I-kappaB kinase/NF-k...sq ~ { t P:regulation of transcriptionsq ~ { t %P:positive regulation of angiogenesissq ~ { t 0P:negative regulation of progression through ...sq ~ { t 0P:negative regulation of receptor mediated en...sq ~ { t P:cell motilitysq ~ { t P:endosome to lysosome transportsq ~ \ { t +P:positive regulation of cell proliferationsq ~ { t 0P:establishment and/or maintenance of cell po...sq ~ * { t P:inflammatory responsesq ~ { t P:transformed cell apoptosissq ~ T { t F:GTPase activitysq ~ { t F:protein bindingsq ~ { t
F:GTP bindingsq ~ x { t F:GTP-dependent protein bindingsq ~ { t F:signal transducer activitysq ~ { t F:GTPase inhibitor activitysq ~ K
{ t F:kinase inhibitor activitysq ~ B { t F:Rho GTPase bindingsq ~ i { t C:cytoplasmsq ~ { t C:plasma membranesq ~ { t C:nucleussq ~ u { t C:filopodiumsq ~ { t &C:proteasome complex (sensu Eukaryota)sq ~ ' { t C:endosome membranepxsq ~ uq ~
sq ~ { t &P:negative regulation of cell adhesiont 7162sq ~ { t !P:Rho protein signal transductiont 7266sq ~ { t )F:Rho GDP-dissociation inhibitor activityt 5094sq ~ { t $C:cytoplasmic membrane-bound vesiclet 16023ppppppxsq ~ uq ~
sq ~ {t IPR000406t Rho_GDIpppppppppxsq ~ uq ~
sq ~ {t Rho_GDIt PF02115pppppppppxt Q99819t
GDIT_HUMANsq ~ uq ~
sq ~ {t Rho GDI 3sq ~ {t
Rho-GDI gammappppppppxt Homo sapienst AURKBsq ~?Md6S ! b " %t "Serine/threonine-protein kinase 12sq ~ uq ~
sq ~ bt ENSG00000178999pppppppppxsq ~ uq ~
sq ~ b t AURKBsq ~ b t AIK2sq ~ b t AIM1sq ~ b t ARK2sq ~ b t STK12pppppxsq ~ uq ~
sq ~ D b t $P:protein amino acid phosphorylationsq ~ K b t P:protein kinase cascadesq ~ b t
P:cytokinesissq ~ b t P:signal transductionsq ~ F b t !P:peptidyl-serine phosphorylationsq ~ b t P:anti-apoptosissq ~ &> b t P:embryonic developmentsq ~ b t (P:protein amino acid autophosphorylationsq ~ b t P:neuroblast proliferationsq ~ b t 0P:cell surface receptor linked signal transdu...sq ~ b t P:signal complex assemblysq ~
b t 0P:transforming growth factor beta receptor co...sq ~ s b t P:spermatogenesissq ~ b t 0P:G-protein signaling, coupled to cGMP nucleo...sq ~ k b t &P:multicellular organismal developmentsq ~ xq b t -P:regulation of actin filament polymerizationsq ~ J b t !P:intracellular signaling cascadesq ~ b t P:meiotic recombinationsq ~ k b t 0P:positive regulation of progression through ...sq ~ b t P:chemotaxissq ~ b t P:muscle contractionsq ~ & b t P:response to stresssq ~ G b t P:ER overload responsesq ~ Y b t 0P:chromosome organization and biogenesis (sen...sq ~ b b t *P:cytoskeleton organization and biogenesissq ~ b t %P:spindle organization and biogenesissq ~ b t P:chromosome segregationsq ~ b t P:mitosissq ~ b t 0P:mitotic cell cycle spindle assembly checkpointsq ~ b t 'P:cytokinesis, initiation of separationsq ~ b t
P:learningsq ~ b t P:feeding behaviorsq ~ b t )P:negative regulation of caspase activitysq ~ b t 0P:positive regulation of gene-specific transc...sq ~ b t )P:negative regulation of neuron apoptosissq ~ b t P:regulation of transcriptionsq ~ b t 'P:positive regulation of anti-apoptosissq ~ g b t *P:establishment of chromosome localizationsq ~ b t 0P:positive regulation of protein export from ...sq ~ b t %P:phosphoinositide-mediated signalingsq ~ Ƥ b t #P:T cell receptor signaling pathwaysq ~ 4 b t %P:regulation of RNA metabolic processsq ~ : b t "P:negative regulation of apoptosissq ~ 9 b t "P:positive regulation of apoptosissq ~ b t 0P:Wnt receptor signaling pathway through beta...sq ~ P b t !P:regulation of heart contractionsq ~ \ b t +P:positive regulation of cell proliferationsq ~ ^ b t $P:insulin receptor signaling pathwaysq ~ b t P:regulation of cell shapesq ~ ' b t P:response to ionizing radiationsq ~ w b t P:tRNA methylationsq ~ { b t P:protein complex localizationsq ~ {0 b t *P:positive regulation of exit from mitosissq ~ {Y b t P:spindle checkpointsq ~ { b t !P:regulation of protein stabilitysq ~ Z b t P:protein heterotetramerizationsq ~ b t P:cell motilitysq ~ b t P:calcium ion transportsq ~ b t -P:negative regulation of cell-matrix adhesionsq ~ b t )P:cytokinesis, contractile ring formationsq ~ b t P:cell morphogenesissq ~ " b t P:vasculogenesissq ~ - b t &P:epithelial to mesenchymal transitionsq ~ V b t 'P:G2/M transition of mitotic cell cyclesq ~ J b t .P:regulation of progression through cell cyclesq ~ b t 0P:regulation of transcription from RNA polyme...sq ~ b t P:DNA repairsq ~ b t 0P:generation of precursor metabolites and energysq ~ @ b t P:protein modification processsq ~ F b t &P:protein amino acid dephosphorylationsq ~ Y b t P:glycogen metabolic processsq ~ W b t P:carbohydrate metabolic processsq ~ b t F:protein bindingsq ~ B b t *F:protein serine/threonine kinase activitysq ~ b t
F:ATP bindingsq ~ b t F:SH2 domain bindingsq ~ k b t 0F:non-membrane spanning protein tyrosine kina...sq ~ @ b t F:protein kinase activitysq ~ 3 b t #F:protein homodimerization activitysq ~ b t F:caspase inhibitor activitysq ~ b t $F:transcription corepressor activitysq ~ 2 b t F:identical protein bindingsq ~ b t
F:p53 bindingsq ~ b t F:alpha-tubulin bindingsq ~ b b t F:chromatin bindingsq ~ t b t F:transcription factor activitysq ~ U b t *F:cyclin-dependent protein kinase activitysq ~ b t #F:phosphoinositide 3-kinase bindingsq ~ ' b t F:insulin bindingsq ~ b t F:PTB domain bindingsq ~ b t %F:protein phosphatase type 1 activitysq ~ s b t F:NF-kappaB bindingsq ~ L b t F:GTPase bindingsq ~ b t F:magnesium ion bindingsq ~ g b t F:beta-tubulin bindingsq ~ b t F:cofactor bindingsq ~ } b t F:protein N-terminus bindingsq ~ b t %F:protein heterodimerization activitysq ~ b t F:SMAD bindingsq ~ b t )F:transforming growth factor beta bindingsq ~ ( b t $F:insulin receptor substrate bindingsq ~ X b t %F:glycogen synthase kinase 3 activitysq ~ d b t F:MAP kinase kinase activitysq ~ b t F:MP kinase activitysq ~ b t 0F:transmembrane receptor protein tyrosine kin...sq ~ b t F:SH3/SH2 adaptor activitysq ~ N b t F:zinc ion bindingsq ~ b t F:transcription factor bindingsq ~ Q b t F:microtubule bindingsq ~ b t F:GTPase activator activitysq ~ b t F:Ras GTPase activator activitysq ~ b t F:receptor bindingsq ~ P b t (F:structural constituent of cytoskeletonsq ~ b t %F:receptor signaling protein activitysq ~ i b t "F:protein-tyrosine kinase activitysq ~ M b t &F:potassium channel inhibitor activitysq ~ b t F:gamma-tubulin bindingsq ~ l b t 0F:receptor signaling protein tyrosine kinase ...sq ~ @, b t /F:tRNA (cytosine-5-)-methyltransferase activitysq ~ ? b t *F:1-phosphatidylinositol-3-kinase activitysq ~ b t F:insulin receptor activitysq ~ b t 0F:transforming growth factor beta receptor ac...sq ~ b t C:nucleussq ~ i b t C:cytoplasmsq ~ b t C:protein complexsq ~ b t C:spindlesq ~ b t C:spindle microtubulesq ~ b t C:integral to plasma membranesq ~ b t C:chromosome, pericentric regionsq ~ w b t C:midbodysq ~ b t &C:proteasome complex (sensu Eukaryota)sq ~ b t C:intermediate filamentsq ~ x b t "C:beta-catenin destruction complexsq ~ b t C:cytosolsq ~ b t C:centriolesq ~ b b t C:nucleolussq ~ Y b t C:centric heterochromatinsq ~ b t C:cytoplasmic microtubulesq ~ y- b t *C:interphase microtubule organizing centerpppppppppppppppppppppxsq ~ uq ~
sq ~ b t F:protein bindingt 5515pppppppppxsq ~ uq ~
sq ~ bt IPR000719t Prot_kinase_coresq ~ bt IPR008271t Ser_thr_pkin_ASsq ~ bt IPR002290t Ser_thr_pkinasepppppppxsq ~ uq ~
sq ~ bt Pkinaset PF00069pppppppppxt Q96GD4t AURKB_HUMANsq ~ uq ~
sq ~ bt Aurora-Bsq ~ bt 1Aurora-and Ipl1-like midbody-associated protein 1sq ~ bt AIM-1sq ~ bt Aurora/IPL1-related kinase 2sq ~ bt Aurora-related kinase 2sq ~ bt STK-1ppppxt Homo sapienst PSA7sq ~?̇s! %t Proteasome subunit alpha type-7sq ~ uq ~
sq ~ t ENSG00000101182pppppppppxsq ~ uq ~
sq ~ t PSMA7pppppppppxsq ~ Auq ~
Psq ~ t P:signal transductionsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ J t .P:regulation of progression through cell cyclesq ~ t $P:central nervous system developmentsq ~ t P:cell adhesionsq ~ t P:mitosissq ~ + t P:immune responsesq ~ * t P:inflammatory responsesq ~ t P:apoptosissq ~ l t
P:proteolysissq ~ @ t P:protein modification processsq ~ . t (P:regulation of translational initiationsq ~ O t
P:circulationsq ~ [ t P:cell proliferationsq ~ t 0P:positive regulation of epithelial cell prol...sq ~ t P:response to hypoxiasq ~ x t 0P:positive regulation of transcription from R...sq ~ r t %P:regulation of epidermis developmentsq ~ 2 t 0P:positive regulation of keratinocyte differe...sq ~ : t "P:negative regulation of apoptosissq ~ D t $P:protein amino acid phosphorylationsq ~ ` t P:homeostatic processsq ~ uT t 0P:actin cytoskeleton organization and biogenesissq ~ # t .P:nucleoside triphosphate biosynthetic processsq ~ ] t +P:negative regulation of cell proliferationsq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t F:protein bindingsq ~ t
F:ATP bindingsq ~ B t *F:protein serine/threonine kinase activitysq ~ A t F:ATPase activitysq ~ t
F:RNA bindingsq ~ t #F:ubiquitin-protein ligase activitysq ~ { t F:GABA receptor bindingsq ~ t )F:metalloendopeptidase inhibitor activitysq ~ t F:signal transducer activitysq ~ ` t $F:NF-kappaB-inducing kinase activitysq ~ t F:actin bindingsq ~ vB t F:LIM domain bindingsq ~ t #F:histone acetyltransferase bindingsq ~ t F:receptor activitysq ~ P t (F:structural constituent of cytoskeletonsq ~ y t 0F:RNA polymerase II transcription factor acti...sq ~ t F:CARD domain bindingsq ~ g t F:beta-tubulin bindingsq ~ t %F:protein heterodimerization activitysq ~ t (F:nucleoside diphosphate kinase activitysq ~ t t F:transcription factor activitysq ~ t F:phosphatidylinositol bindingsq ~ O t F:endopeptidase activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:rufflesq ~ uK t C:lamellipodiumsq ~ t C:cytoskeletonsq ~ t
C:polysomesq ~ t +C:proteasome core complex (sensu Eukaryota)sq ~ t C:centrosomesq ~ t C:autophagic vacuolesq ~ # t C:transcription factor complexsq ~ t 0C:proteasome regulatory particle (sensu Eukar...sq ~ t
C:spectrinsq ~ t C:plasma membranesq ~ t C:protein complexpppppppppppppppxsq ~ uq ~
sq ~ t F:protein bindingt 5515sq ~ t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ t IPR001353t Proteasome_A_Bsq ~ t IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt O14818t
PSA7_HUMANsq ~ uq ~
sq ~ t Proteasome subunit RC6-1sq ~ t Proteasome subunit XAPC7ppppppppxt Homo sapienst PSA6sq ~?kZֵ_ %t Proteasome subunit alpha type-6sq ~ uq ~
sq ~ t ENSG00000100902pppppppppxsq ~ uq ~
sq ~ t PSMA6sq ~ t PROS27ppppppppxsq ~ Duq ~
Psq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ J t .P:regulation of progression through cell cyclesq ~ t P:signal transductionsq ~ @ t P:protein ubiquitinationsq ~ & t P:response to stresssq ~ D t $P:protein amino acid phosphorylationsq ~ t 0P:RNA elongation from RNA polymerase II promotersq ~ t P:anti-apoptosissq ~ t P:apoptosissq ~ t P:sodium ion transportsq ~ . t (P:regulation of translational initiationsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ n t P:ATP-dependent proteolysissq ~ l t
P:proteolysissq ~ * t P:inflammatory responsesq ~ t P:mitosissq ~ ƶ t *P:positive regulation of T cell activationsq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ ƅ t P:protein stabilizationsq ~ t -P:positive regulation of cell differentiationsq ~ t P:proteasome assemblysq ~ uT t 0P:actin cytoskeleton organization and biogenesissq ~ [ t P:cell proliferationsq ~ O t
P:circulationsq ~ R t )P:activation of NF-kappaB-inducing kinasesq ~ t ,P:regulation of transcription, DNA-dependentsq ~ + t P:immune responsesq ~ z t 0P:negative regulation of transcription from R...sq ~
t 0P:positive regulation of T cell cytokine prod...sq ~ ] t +P:negative regulation of cell proliferationsq ~ t P:cell morphogenesissq ~ t P:protein polyubiquitinationsq ~ t F:protein bindingsq ~ B t *F:protein serine/threonine kinase activitysq ~ t #F:ubiquitin-protein ligase activitysq ~ t t F:transcription factor activitysq ~ t F:signal transducer activitysq ~ ` t $F:NF-kappaB-inducing kinase activitysq ~ t F:transcription factor bindingsq ~ t )F:metalloendopeptidase inhibitor activitysq ~ t
F:RNA bindingsq ~ M t F:kinase bindingsq ~ t F:phosphatidylinositol bindingsq ~ !Z t F:proteasome activator activitysq ~ t F:CARD domain bindingsq ~ vB t F:LIM domain bindingsq ~ A t F:ATPase activitysq ~ t
F:ATP bindingsq ~ t $F:transcription coactivator activitysq ~ P t (F:structural constituent of cytoskeletonsq ~ t F:receptor activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:protein complexsq ~ t 0C:proteasome regulatory particle (sensu Eukar...sq ~ t
C:spectrinsq ~ t C:ubiquitin ligase complexsq ~ t C:integral to plasma membranesq ~ t C:cytosolsq ~ W t !C:perinuclear region of cytoplasmsq ~ t C:endoplasmic reticulumsq ~ t C:centrosomesq ~ k t C:mitochondrionsq ~ t C:membrane fractionsq ~ t C:Bcl3/NF-kappaB2 complexsq ~ t
C:polysomesq ~ t C:plasma membraneppppppppppppxsq ~ uq ~
sq ~ t /P:ubiquitin-dependent protein catabolic processt 6511sq ~ t F:endopeptidase activityt 4175sq ~ t F:protein bindingt 5515sq ~ t
F:RNA bindingt 3723sq ~ t +C:proteasome core complex (sensu Eukaryota)t 5839pppppxsq ~ uq ~
sq ~ t IPR001353t Proteasome_A_Bsq ~ t IPR000426t Proteasome_alphappppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt P60900t
PSA6_HUMANsq ~ uq ~
sq ~ t Proteasome iota chainsq ~ t Macropain iota chainsq ~ t /Multicatalytic endopeptidase complex iota chainsq ~ t 27 kDa prosomal proteinsq ~ t PROS-27sq ~ t p27Kppppxt Homo sapienst PAI2sq ~ %t +Plasminogen activator inhibitor 2 precursorsq ~ uq ~
sq ~ t ENSG00000197632pppppppppxsq ~ uq ~
sq ~ t SERPINB2sq ~ t PAI2sq ~ t PLANH2pppppppxsq ~ uq ~
(sq ~ K t P:cell cycle checkpointsq ~ E t 0P:negative regulation of protein kinase activitysq ~ l t
P:proteolysissq ~ t P:chemotaxissq ~ t P:signal transductionsq ~ t P:RNA splicingsq ~ vd t $P:negative regulation of cell growthsq ~ w9 t %P:androgen receptor signaling pathwaysq ~ t %P:regulation of lipid kinase activitysq ~ E t 0P:positive regulation of transcription, DNA-d...sq ~ t P:mRNA processingsq ~ t /P:transcription from RNA polymerase II promotersq ~ v t
P:G1 phasesq ~ z t 0P:negative regulation of transcription from R...sq ~ t P:M phasesq ~ t F:protein bindingsq ~ t F:androgen receptor bindingsq ~ y t 0F:RNA splicing factor activity, transesterifi...sq ~ M t F:kinase bindingsq ~ t t F:transcription factor activitysq ~ v t 0F:RNA polymerase II transcription factor acti...sq ~ t !F:transcription cofactor activitysq ~ t $F:transcription coactivator activitysq ~ @ t
C:PML bodysq ~ t C:chromatinsq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ 2 t
C:snRNP U5pppppppppppppxsq ~ uq ~
sq ~ t P:anti-apoptosist 6916pppppppppxsq ~ uq ~
sq ~ t IPR000215t Protease_inhib_I4_serpinsq ~ t IPR015556t Protease_inhib_serine_PAI-2ppppppppxsq ~ uq ~
sq ~ t Serpint PF00079pppppppppxt P05120t
PAI2_HUMANsq ~ uq ~
sq ~ t PAI-2sq ~ t )Placental plasminogen activator inhibitorsq ~ t Monocyte Arg-serpinsq ~ t Urokinase inhibitorppppppxt Homo sapienst VINCsq ~?i @V %t Vinculinsq ~ uq ~
sq ~ @Vt ENSG00000035403pppppppppxsq ~ uq ~
sq ~ @V t VCLpppppppppxsq ~ Ruq ~
sq ~ @V t P:signal transductionsq ~ @V t P:cell adhesionsq ~ @V t P:focal adhesion formationsq ~ @V t P:cell motilitysq ~ @V t P:RNA splicingsq ~ @V t P:anti-apoptosissq ~ 9 @V t P:protein foldingsq ~ @V t (P:nuclear mRNA splicing, via spliceosomesq ~ @V t
P:translationsq ~ @V t P:RNA processingsq ~ @V t P:regulation of apoptosissq ~ @V t P:mRNA processingsq ~ [ @V t P:cell proliferationsq ~ @V t P:spliceosome assemblysq ~ J @V t P:response to unfolded proteinsq ~ @V t P:homophilic cell adhesionsq ~ @V t 0P:cell surface receptor linked signal transdu...sq ~ @V t P:signal complex assemblysq ~ @V t P:muscle contractionsq ~ . @V t (P:regulation of translational initiationsq ~ k @V t &P:multicellular organismal developmentsq ~ J @V t .P:regulation of progression through cell cyclesq ~ ^ @V t $P:insulin receptor signaling pathwaysq ~ @] @V t P:cell migrationsq ~ H @V t &P:positive regulation of cell motilitysq ~ !` @V t P:epidermis developmentsq ~ @V t P:transportsq ~ = @V t %P:integrin-mediated signaling pathwaysq ~ @a @V t &P:negative regulation of transcriptionsq ~ : @V t "P:negative regulation of apoptosissq ~ @V t P:stress fiber formationsq ~ = @V t P:glucose transportsq ~ @V t P:protein import into nucleussq ~ @ @V t P:protein modification processsq ~ @V t ,P:melanin biosynthetic process from tyrosinesq ~ o @V t /P:ubiquitin-dependent protein catabolic processsq ~ l @V t
P:proteolysissq ~ m @V t )P:membrane protein ectodomain proteolysissq ~ @V t P:translational elongationsq ~ D @V t $P:protein amino acid phosphorylationsq ~ @V t P:mRNA polyadenylationsq ~ : @V t P:protein transportsq ~ =5 @V t P:gas transportsq ~ =f @V t P:monocarboxylic acid transportsq ~ ?@ @V t P:vesicle-mediated transportsq ~ @ @V t P:chromatin modificationsq ~ @ @V t P:protein ubiquitinationsq ~ ! @V t P:apical junction assemblysq ~ F @V t #P:peptidyl-tyrosine phosphorylationsq ~ ' @V t P:response to X-raysq ~ ' @V t $P:response to extracellular stimulussq ~ @V t ,P:regulation of transcription, DNA-dependentsq ~ @V t $P:DNA fragmentation during apoptosissq ~ @V t P:double-strand break repairsq ~ @V t P:glycolysissq ~ @V t %P:glycosaminoglycan catabolic processsq ~ % @V t P:response to woundingsq ~ % @V t P:UV protectionsq ~ % @V t $P:anatomical structure morphogenesissq ~ @V t 0P:Wnt receptor signaling pathway through beta...sq ~ @V t P:protein retention in ERsq ~ @V t P:lipid metabolic processsq ~ @V t 0P:transmembrane receptor protein tyrosine kin...sq ~ ! @V t 0P:induction of apoptosis by extracellular sig...sq ~ K @V t P:protein kinase cascadesq ~ ` @V t +P:small GTPase mediated signal transductionsq ~ d @V t P:synaptic transmissionsq ~ s @V t P:spermatogenesissq ~ @V t P:axon guidancesq ~ @V t $P:central nervous system developmentsq ~ _ @V t P:striated muscle developmentsq ~ P @V t !P:regulation of heart contractionsq ~ # @V t .P:nucleoside triphosphate biosynthetic processsq ~ ! @V t %P:caspase activation via cytochrome csq ~ ! @V t .P:release of cytoplasmic sequestered NF-kappaBsq ~ @V t .P:actin polymerization and/or depolymerizationsq ~ ] @V t +P:negative regulation of cell proliferationsq ~ @V t P:regulation of cell shapesq ~ @V t *P:calcium-independent cell-matrix adhesionsq ~ $ @V t P:response to coldsq ~ @V t P:fatty acid beta-oxidationsq ~ @V t !P:mitochondrial citrate transportsq ~ @V t P:cellular iron ion homeostasissq ~ @V t !P:intracellular protein transportsq ~ @V t P:exocytosissq ~ @V t P:apoptosissq ~ @V t !P:intercellular junction assemblysq ~ @V t P:induction of apoptosissq ~ @V t P:caspase activationsq ~ @V t P:striated muscle contractionsq ~ * @V t P:inflammatory responsesq ~ 8 @V t P:cellular defense responsesq ~ U @V t %P:nuclear organization and biogenesissq ~ h @V t P:cytoskeletal anchoringsq ~ v @V t #P:Golgi organization and biogenesissq ~ @V t P:cell cyclesq ~ a @V t !P:Ras protein signal transductionsq ~ uS @V t P:microspike biogenesissq ~ V @V t 'P:G2/M transition of mitotic cell cyclesq ~ r @V t %P:regulation of epidermis developmentsq ~ @V t P:cell cycle arrestsq ~ 2 @V t 0P:positive regulation of keratinocyte differe...sq ~ @V t P:cellular respirationsq ~ @V t )P:blood vessel endothelial cell migrationsq ~ @V t P:skeletal developmentsq ~ s @V t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ @V t %P:regulation of macrophage activationsq ~ @V t P:muscle cell differentiationsq ~ @V t 'P:regulation of RNA export from nucleussq ~ @V t P:response to drugsq ~ @V t +P:natural killer cell mediated cytotoxicitysq ~ N @V t 0P:long-term strengthening of neuromuscular ju...sq ~ E @V t 0P:positive regulation of transcription, DNA-d...sq ~ u @V t &P:positive regulation of transcriptionsq ~ Y @V t P:protein homotetramerizationsq ~ @V t
P:cytokinesissq ~ @V t $P:prostaglandin biosynthetic processsq ~ @V t P:angiogenesissq ~ G @V t &P:negative regulation of cell motilitysq ~ - @V t &P:epithelial to mesenchymal transitionsq ~ H @V t #P:barbed-end actin filament cappingsq ~ F @V t P:actin filament severingsq ~ @V t P:leukocyte migrationsq ~ @V t 0P:positive regulation of epithelial cell prol...sq ~ @V t P:mRNA stabilizationsq ~ ' @V t #P:regulation of synaptic plasticitysq ~ @V t %P:phosphoinositide-mediated signalingsq ~ ~ @V t 0P:positive regulation of sodium:hydrogen anti...sq ~ u` @V t P:actin filament-based movementsq ~ v @V t )P:ER-associated protein catabolic processsq ~ v @V t 'P:positive regulation of cell migrationsq ~ v
@V t P:erythrocyte differentiationsq ~ v @V t P:muscle thin filament assemblysq ~ v @V t P:monocyte differentiationsq ~ v @V t P:platelet formationsq ~ u @V t P:cell differentiationsq ~ uY @V t P:actin filament polymerizationsq ~ ua @V t P:muscle filament slidingsq ~ w9 @V t %P:androgen receptor signaling pathwaysq ~ uT @V t 0P:actin cytoskeleton organization and biogenesissq ~ {, @V t #P:actin cytoskeleton reorganizationsq ~ t @V t P:DNA replicationsq ~ : @V t F:protein bindingsq ~
@V t
F:RNA bindingsq ~ @V t F:calcium ion bindingsq ~ @V t $F:structural constituent of ribosomesq ~ P @V t (F:structural constituent of cytoskeletonsq ~ @V t F:actin bindingsq ~ C @V t F:vinculin bindingsq ~ @V t
F:ATP bindingsq ~ NJ @V t F:unfolded protein bindingsq ~ 3 @V t #F:protein homodimerization activitysq ~ ] @V t
F:DNA bindingsq ~ @V t F:SH3/SH2 adaptor activitysq ~ : @V t F:integrin bindingsq ~ s @V t "F:structural constituent of musclesq ~ N @V t F:zinc ion bindingsq ~ @V t
F:GTP bindingsq ~ @ @V t "F:transcription repressor activitysq ~ @V t F:collagen bindingsq ~ 2 @V t F:identical protein bindingsq ~ & @V t F:insulin receptor bindingsq ~ p @V t F:bindingsq ~ G @V t F:actin filament bindingsq ~ j @V t F:double-stranded DNA bindingsq ~ B~ @V t F:myosin bindingsq ~ @V t F:heparin bindingsq ~ @V t %F:ATP-dependent RNA helicase activitysq ~ b @V t F:lipoprotein bindingsq ~ i @V t "F:protein-tyrosine kinase activitysq ~ @V t F:receptor activitysq ~ @V t (F:translation initiation factor activitysq ~ @V t F:poly(A) bindingsq ~ @V t F:SH2 domain bindingsq ~ @V t F:signal transducer activitysq ~ M @V t F:kinase bindingsq ~ NE @V t F:heme bindingsq ~ !Z @V t F:proteasome activator activitysq ~ 0 @V t F:MHC class I protein bindingsq ~ Ȫ @V t F:ZASP bindingsq ~ Ǐ @V t F:chaperone bindingsq ~ B @V t F:5'-flap endonuclease activitysq ~ M @V t F:protein kinase bindingsq ~ Ȯ @V t F:FATZ 1 bindingsq ~ ȫ @V t F:muscle alpha-actinin bindingsq ~ !. @V t F:translation activator activitysq ~ A @V t F:ATPase activitysq ~ @V t F:protein anchorsq ~ > @V t *F:low-density lipoprotein receptor bindingsq ~ ;! @V t ,F:citrate transmembrane transporter activitysq ~ @V t F:ribosome bindingsq ~ B @V t F:SH3 domain bindingsq ~ @V t 0F:ATPase activity, coupled to transmembrane m...sq ~ @V t F:ATPase activity, coupledsq ~ w@ @V t "F:transcription regulator activitysq ~ @V t
F:ADP bindingsq ~ ;g @V t ,F:adenine transmembrane transporter activitysq ~ A @V t F:prolyl aminopeptidase activitysq ~ c @V t 0F:electron transporter, transferring electron...sq ~ @V t F:androgen receptor bindingsq ~ u @V t F:manganese ion bindingsq ~ @V t F:protein dimerization activitysq ~ v @V t "F:thyroid hormone receptor bindingsq ~ ? @V t /F:protein-arginine N-methyltransferase activitysq ~ vB @V t F:LIM domain bindingsq ~ x @V t !F:actin-dependent ATPase activitysq ~ @V t F:5'-3' exonuclease activitysq ~ @V t F:laminin receptor activitysq ~ @V t F:phospholipase C activitysq ~ @V t "F:phosphoglycerate mutase activitysq ~ @V t F:alpha-L-fucosidase activitysq ~ @V t (F:nucleoside diphosphate kinase activitysq ~ k @V t "F:L-lactate dehydrogenase activitysq ~ Q @V t -F:extracellular matrix structural constituentsq ~
@V t 0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq ~ @V t F:enoyl-CoA hydratase activitysq ~ @V t F:lipid transporter activitysq ~ R @V t F:leucyl aminopeptidase activitysq ~ G @V t F:dopachrome isomerase activitysq ~ @V t %F:ATP-dependent DNA helicase activitysq ~ @V t 'F:acetyl-CoA C-acyltransferase activitysq ~ T @V t F:GTPase activitysq ~ Y @V t F:protein kinase C activitysq ~ @V t #F:ubiquitin-protein ligase activitysq ~ @V t "F:phospholipase inhibitor activitysq ~ @V t %F:receptor signaling protein activitysq ~ @V t ,F:guanyl-nucleotide exchange factor activitysq ~ @V t F:receptor bindingsq ~ @V t F:cytokine activitysq ~ @V t F:interleukin-1 receptor bindingsq ~ N @V t F:structural molecule activitysq ~ @V t F:scavenger receptor activitysq ~ @V t F:transferrin receptor activitysq ~ @V t &F:asialoglycoprotein receptor activitysq ~ _ @V t F:transporter activitysq ~ @V t F:copper ion bindingsq ~ @V t F:calmodulin bindingsq ~ @V t F:lamin bindingsq ~ @V t .F:serine-type endopeptidase inhibitor activitysq ~ @V t *F:3-hydroxyacyl-CoA dehydrogenase activitysq ~ e @V t &F:cysteine-type endopeptidase activitysq ~ @V t $F:transcription coactivator activitysq ~ @V t F:cytoskeletal adaptor activitysq ~ \ @V t 0F:monocarboxylic acid transmembrane transport...sq ~ V @V t F:protein C-terminus bindingsq ~ @V t F:ribonuclease H activitysq ~ Z @V t F:nucleoside bindingsq ~ @V t F:nucleotide bindingsq ~ @V t F:magnesium ion bindingsq ~ S @V t F:RNA cap bindingsq ~ @V t F:microfilament motor activitysq ~ @V t F:transcription factor bindingsq ~ d @V t F:damaged DNA bindingsq ~ @V t &F:protein disulfide isomerase activitysq ~ @V t F:RNA helicase activitysq ~ @V t F:motor activitysq ~ u @V t 0F:double-stranded DNA specific exodeoxyribonu...sq ~ Z @V t !F:ATP-dependent helicase activitysq ~ t @V t F:transcription factor activitysq ~ q @V t F:single-stranded DNA bindingsq ~ J @V t F:poly(U) bindingsq ~ @V t C:nucleussq ~ i @V t C:cytoplasmsq ~ @V t C:cytosolsq ~ 1 @V t
C:spliceosomesq ~ @V t C:plasma membranesq ~ @V t C:integral to plasma membranesq ~ % @V t C:focal adhesionsq ~ @V t C:membrane fractionsq ~ > @V t C:integral to membranesq ~ @V t C:rufflesq ~ @V t C:cytoskeletonsq ~ @V t 0C:cytosolic small ribosomal subunit (sensu Eu...sq ~ wB @V t 0C:heterogeneous nuclear ribonucleoprotein com...sq ~ wD @V t )C:small nuclear ribonucleoprotein complexsq ~ @V t C:stress fibersq ~ @V t C:actin filamentsq ~ =
@V t C:actin cytoskeletonsq ~ @V t &C:proteasome complex (sensu Eukaryota)sq ~ @V t C:extracellular regionsq ~ y @V t C:pseudopodiumsq ~ @V t C:endoplasmic reticulumsq ~ uK @V t C:lamellipodiumsq ~ @V t C:intracellularsq ~ @V t #C:ER-Golgi intermediate compartmentsq ~ > @V t
C:membranesq ~ b @V t C:nucleolussq ~ $ @V t "C:cell-substrate adherens junctionsq ~ A @V t C:lipid raftsq ~ u @V t C:filopodiumsq ~ @V t C:protein complexsq ~ @V t %C:protein phosphatase type 2A complexsq ~ : @V t C:Cajal bodysq ~ @V t C:dendritic spinesq ~ W @V t !C:perinuclear region of cytoplasmsq ~ @V t C:postsynaptic membranesq ~ !Y @V t C:proteasome activator complexsq ~ ? @V t 0C:eukaryotic translation initiation factor 4F...sq ~ ? @V t C:lateral plasma membranesq ~ @M @V t C:unconventional myosin complexsq ~ @V t C:striated muscle thin filamentsq ~ @V t 0C:eukaryotic translation elongation factor 1 ...sq ~ @V t 0C:eukaryotic translation initiation factor 3 ...sq ~ @V t
C:polysomesq ~ @V t C:contractile ringsq ~ @V t C:microtubule associated complexsq ~ @V t C:intermediate filamentsq ~ > @V t $C:cytoplasmic membrane-bound vesiclesq ~ ' @V t C:muscle tendon junctionsq ~ ' @V t C:cell surfacesq ~ @V t C:fascia adherenssq ~ @V t C:zonula adherenssq ~ 0 @V t C:endomembrane systemsq ~ @V t C:cell-cell adherens junctionsq ~ @V t C:intercellular junctionsq ~ @V t C:Arp2/3 protein complexsq ~ @V t C:centrosomesq ~ @V t C:trans-Golgi networksq ~ @V t C:extracellular spacesq ~ @V t C:collagen type VIIIsq ~ wA @V t C:ribonucleoprotein complexsq ~ x @V t "C:beta-catenin destruction complexsq ~ @V t $C:proteinaceous extracellular matrixsq ~ } @V t C:cleavage furrowsq ~ @V t C:paraspecklessq ~ @V t C:melanosomesq ~ @V t C:soluble fractionsq ~ @V t C:nuclear envelopesq ~ @V t
C:nucleoplasmsq ~ @V t C:Golgi apparatussq ~ @V t C:microsomesq ~ @V t
C:endosomesq ~ ~ @V t #C:mitochondrial intermembrane spacesq ~ o @V t C:mitochondrial inner membranesq ~ l @V t C:mitochondrial envelopesq ~ k @V t C:mitochondrionsq ~ u @V t C:clathrin coatsq ~ z @V t 0C:mitochondrial proton-transporting ATP synth...ppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ @V t 'P:negative regulation of cell migrationt 30336sq ~ @V t P:lamellipodium biogenesist 30032sq ~ @V t P:cell adhesiont 7155sq ~ @V t P:apical junction assemblyt 43297sq ~ @V t F:oxidoreductase activityt 16491sq ~ @V t F:alpha-catenin bindingt 45294sq ~ @V t C:protein complext 43234sq ~ @V t C:intercellular junctiont 5911sq ~ @V t C:focal adhesiont 5925sq ~ @V t C:cytoskeletont 5856sq ~ @V t C:costameret 43034pppppppppxsq ~ uq ~
sq ~ @Vt IPR006077t Vinculin/cateninsq ~ @Vt IPR000633t
Vinculin_2ppppppppxsq ~ uq ~
sq ~ @Vt Vinculint PF01044pppppppppxt P18206t
VINC_HUMANsq ~ uq ~
sq ~ @Vt Metavinculinpppppppppxt Homo sapienst PSMD6sq ~?ΓΎ 4 Q 4 %t .26S proteasome non-ATPase regulatory subunit 6sq ~ uq ~
sq ~ Qt ENSG00000163636pppppppppxsq ~ uq ~
sq ~ Q t PSMD6sq ~ Q t KIAA0107sq ~ Q t PFAAP4pppppppxsq ~ Tuq ~
sq ~ Q t P:signal transductionsq ~ o Q t /P:ubiquitin-dependent protein catabolic processsq ~ D Q t $P:protein amino acid phosphorylationsq ~ & Q t P:response to stresssq ~ Q t P:induction of apoptosissq ~ l Q t
P:proteolysissq ~ . Q t (P:regulation of translational initiationsq ~ s Q t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ Q t /P:transcription from RNA polymerase II promotersq ~ Q t P:male meiosis Isq ~ J Q t P:response to unfolded proteinsq ~ + Q t P:immune responsesq ~ Q t P:sodium ion transportsq ~ Q t P:muscle contractionsq ~ Q t P:cell motilitysq ~ 9 Q t P:protein foldingsq ~ Q t P:apoptosissq ~ Q t P:anti-apoptosissq ~
Q t P:translational initiationsq ~ Q t P:electron transportsq ~ Q t P:nucleotide-excision repairsq ~ Q t P:potassium ion transportsq ~ R Q t )P:activation of NF-kappaB-inducing kinasesq ~ J Q t .P:regulation of progression through cell cyclesq ~ * Q t P:inflammatory responsesq ~ = Q t .P:negative regulation of programmed cell deathsq ~ Q t 0P:proteasomal ubiquitin-dependent protein cat...sq ~ Q t 0P:positive regulation of gene-specific transc...sq ~ Ƥ Q t #P:T cell receptor signaling pathwaysq ~
Q t 0P:positive regulation of T cell cytokine prod...sq ~ ƶ Q t *P:positive regulation of T cell activationsq ~ Q t P:mitotic cell cyclesq ~ Q t P:protein polyubiquitinationsq ~ y Q t ,P:regulation of centriole-centriole cohesionsq ~ x Q t !P:epithelial cell differentiationsq ~ V Q t
P:JNK cascadesq ~ s Q t P:spermatogenesissq ~ ] Q t P:muscle developmentsq ~ Q t P:sensory perception of soundsq ~ P Q t !P:regulation of heart contractionsq ~ Q t P:mammary gland involutionsq ~ !` Q t P:epidermis developmentsq ~ $ Q t 0P:folic acid and derivative biosynthetic processsq ~ $ Q t F:protein bindingsq ~ A Q t F:ATPase activitysq ~ Q t
F:RNA bindingsq ~ Q t
F:ATP bindingsq ~ B Q t *F:protein serine/threonine kinase activitysq ~ Q t $F:transcription coactivator activitysq ~ Q t !F:transcription cofactor activitysq ~ Q t 0F:methylenetetrahydrofolate dehydrogenase (NA...sq ~ } Q t 0F:methenyltetrahydrofolate cyclohydrolase act...sq ~ @ Q t "F:transcription repressor activitysq ~ Q t *F:formate-tetrahydrofolate ligase activitysq ~ M Q t F:protein kinase bindingsq ~ u Q t F:chaperone regulator activitysq ~ q Q t F:single-stranded DNA bindingsq ~ w, Q t 0F:thiol-disulfide exchange intermediate activitysq ~ t Q t F:transcription factor activitysq ~ O Q t F:endopeptidase activitysq ~ Q t $F:structural constituent of ribosomesq ~ {+ Q t 0F:thyrotropin-releasing hormone receptor bindingsq ~ Q t $F:transcription corepressor activitysq ~ w Q t F:protein binding, bridgingsq ~ ` Q t $F:NF-kappaB-inducing kinase activitysq ~ Q t .F:delayed rectifier potassium channel activitysq ~ _ Q t F:transporter activitysq ~ Q t F:receptor activitysq ~ Q t F:signal transducer activitysq ~ Q t #F:ubiquitin-protein ligase activitysq ~ Q t &C:proteasome complex (sensu Eukaryota)sq ~ Q t C:nucleussq ~ Q t 0C:proteasome regulatory particle (sensu Eukar...sq ~ i Q t C:cytoplasmsq ~ Q t C:cytoskeletonsq ~ Q t
C:polysomesq ~ Q t +C:proteasome core complex (sensu Eukaryota)sq ~ Q t C:cytosolsq ~ Q t C:centrosomesq ~ Q t 0C:cytosolic small ribosomal subunit (sensu Eu...sq ~ y Q t 0C:mitochondrial proton-transporting ATP synth...sq ~ = Q t C:microtubule cytoskeletonsq ~ ' Q t C:cell surfacesq ~ Q t )C:voltage-gated potassium channel complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ Q t P:ATP-dependent proteolysist 6510sq ~ Q t F:ATPase activityt 16887sq ~ Q t F:protein bindingt 5515sq ~ Q t &C:proteasome complex (sensu Eukaryota)t 502ppppppxsq ~ uq ~
sq ~ Qt IPR000717t PCIpppppppppxsq ~ uq ~
sq ~ Qt PCIt PF01399pppppppppxt Q15008t PSMD6_HUMANsq ~ uq ~
sq ~ Qt %26S proteasome regulatory subunit S10sq ~ Qt p42Asq ~ Qt -Proteasome regulatory particle subunit p44S10sq ~ Qt ,Phosphonoformate immuno-associated protein 4sq ~ Qt )Breast cancer-associated protein SGA-113Mpppppxt Homo sapienst TRAF6sq ~?Mc z T { %t TNF receptor-associated factor 6sq ~ uq ~
sq ~ Tt ENSG00000175104pppppppppxsq ~ uq ~
sq ~ T t TRAF6sq ~ T t RNF85ppppppppxsq ~ uq ~
sq ~ T t P:signal transductionsq ~ s
T t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ T t
P:translationsq ~ T t P:cell motilitysq ~ [
T t P:cell proliferationsq ~ o
T t /P:ubiquitin-dependent protein catabolic processsq ~ T t P:anti-apoptosissq ~ 9 T t P:protein foldingsq ~ D T t $P:protein amino acid phosphorylationsq ~ J T t .P:regulation of progression through cell cyclesq ~ T t 0P:cell surface receptor linked signal transdu...sq ~ & T t P:response to stresssq ~ t T t P:DNA replicationsq ~ J T t P:response to unfolded proteinsq ~ T t 0P:G-protein coupled receptor protein signalin...sq ~ T t 0P:regulation of transcription from RNA polyme...sq ~ = T t P:protein complex assemblysq ~ R T t )P:activation of NF-kappaB-inducing kinasesq ~ @ T t P:protein ubiquitinationsq ~ F T t &P:protein amino acid dephosphorylationsq ~ @ T t P:protein modification processsq ~ . T t (P:regulation of translational initiationsq ~ T t 0P:nucleobase, nucleoside, nucleotide and nucl...sq ~ ] T t +P:negative regulation of cell proliferationsq ~ T t P:cell cycle arrestsq ~ T t /P:transcription from RNA polymerase II promotersq ~ + T t P:immune responsesq ~ * T t P:inflammatory responsesq ~ T t P:apoptosissq ~ T t !P:intracellular protein transportsq ~ K T t P:protein kinase cascadesq ~ Ƥ T t #P:T cell receptor signaling pathwaysq ~ !` T t P:epidermis developmentsq ~ T t P:induction of apoptosissq ~ ƶ T t *P:positive regulation of T cell activationsq ~ ( T t P:defense responsesq ~ \ T t +P:positive regulation of cell proliferationsq ~
T t 0P:positive regulation of T cell cytokine prod...sq ~ T t P:DNA repairsq ~ z T t 0P:negative regulation of transcription from R...sq ~ T t P:nucleosome assemblysq ~ T t P:mRNA processingsq ~
T t P:translational initiationsq ~ T t P:electron transportsq ~ ǔ T t .P:activation of NF-kappaB transcription factorsq ~ T t P:glycolysissq ~ l T t
P:proteolysissq ~ T t P:lipid metabolic processsq ~ ` T t +P:small GTPase mediated signal transductionsq ~ W T t P:carbohydrate metabolic processsq ~ uT T t 0P:actin cytoskeleton organization and biogenesissq ~ T t P:cell cyclesq ~ T t 0P:positive regulation of gene-specific transc...sq ~ D T t 0P:negative regulation of transcription, DNA-d...sq ~ T t (P:protein amino acid autophosphorylationsq ~ u T t &P:positive regulation of transcriptionsq ~ Q T t #P:I-kappaB kinase/NF-kappaB cascadesq ~ T t %P:phosphoinositide-mediated signalingsq ~ v T t )P:ER-associated protein catabolic processsq ~ x T t 0P:positive regulation of transcription from R...sq ~ T t P:anion transportsq ~ w9 T t %P:androgen receptor signaling pathwaysq ~ T t P:transportsq ~ T t
P:endocytosissq ~ T t P:nucleocytoplasmic transportsq ~ T t P:protein export from nucleussq ~ T t P:regulation of apoptosissq ~ O T t P:protein amino acid methylationsq ~ T t 0P:regulation of interleukin-12 biosynthetic p...sq ~ T t P:caspase activationsq ~ T t P:translational elongationsq ~ T t P:RNA processingsq ~ T t P:chemotaxissq ~ T t P:DNA recombinationsq ~ t T t 0P:negative regulation of I-kappaB kinase/NF-k...sq ~ T t P:cell adhesionsq ~ I T t !P:actin filament bundle formationsq ~ ȍ T t 'P:regulation of oxidoreductase activitysq ~ K T t 0P:cytokine and chemokine mediated signaling p...sq ~ T t P:nervous system developmentsq ~ T t P:spermatid differentiationsq ~ [ T t P:protein heterooligomerizationsq ~ ; T t P:protein oligomerizationsq ~ T t P:RNA splicingsq ~ T t $P:DNA double-strand break processingsq ~ T t P:activation of MAPKKK activitysq ~ >x T t P:proton transportsq ~ : T t P:protein transportsq ~ g T t 0P:negative regulation of osteoclast different...sq ~ T t P:protein localizationsq ~ R T t 'P:G1/S transition of mitotic cell cyclesq ~ T t $P:prostaglandin biosynthetic processsq ~ ! T t %P:caspase activation via cytochrome csq ~ # T t P:threonyl-tRNA aminoacylationsq ~ T t P:regulation of translationsq ~ @ T t P:protein deubiquitinationsq ~ T t P:tRNA modificationsq ~ & T t P:organ morphogenesissq ~ F T t #P:peptidyl-tyrosine phosphorylationsq ~ T t P:nucleotide-excision repairsq ~ '1 T t P:response to organic substancesq ~ T t P:mRNA polyadenylationsq ~ % T t P:tyrosyl-tRNA aminoacylationsq ~ T t P:protein targetingsq ~ T t P:glutamate catabolic processsq ~ # T t .P:ribonucleoside diphosphate catabolic processsq ~ n T t P:ATP-dependent proteolysissq ~ $Z T t P:protein secretionsq ~ J T t +P:N-terminal protein amino acid acetylationsq ~ G T t %P:protein amino acid ADP-ribosylationsq ~ T t 0P:negative regulation of tyrosine phosphoryla...sq ~ E T t 0P:negative regulation of protein kinase activitysq ~ %} T t P:detection of virussq ~ % T t $P:anatomical structure morphogenesissq ~ &> T t P:embryonic developmentsq ~ % T t P:response to virussq ~ 1 T t )P:regulation of translational terminationsq ~ # T t P:nucleotide metabolic processsq ~ T t 0P:transcription initiation from RNA polymeras...sq ~ a T t P:CTP biosynthetic processsq ~ E T t )P:pyrimidine nucleoside metabolic processsq ~ - T t $P:'de novo' IMP biosynthetic processsq ~ T t P:purine ribonucleoside salvagesq ~ T t (P:purine nucleotide biosynthetic processsq ~ ?E T t P:endosome transportsq ~ ?J T t +P:regulation of striated muscle developmentsq ~ T t 0P:tricarboxylic acid cycle intermediate metab...sq ~ ? T t P:dephosphorylationsq ~ ? T t P:cell-cell adhesionsq ~ uY T t P:actin filament polymerizationsq ~ u T t P:protein repairsq ~ @a T t &P:negative regulation of transcriptionsq ~ u T t .P:regulation of Wnt receptor signaling pathwaysq ~ > T t P:mRNA metabolic processsq ~ | T t "P:DNA unwinding during replicationsq ~ ~ T t P:DNA replication initiationsq ~ @ T t P:histone ubiquitinationsq ~ =p T t P:mevalonate transportsq ~ T t ,P:regulation of transcription, DNA-dependentsq ~ T t P:transcriptionsq ~ T t P:nucleosome disassemblysq ~ T t $P:DNA fragmentation during apoptosissq ~ T t P:double-strand break repairsq ~ T t P:postreplication repairsq ~ T t P:mismatch repairsq ~ T t $P:base-excision repair, DNA ligationsq ~ T t P:base-excision repairsq ~ T t P:regulation of DNA repairsq ~ > T t
P:cell growthsq ~ T t P:regulation of DNA replicationsq ~ u T t P:regulation of cell adhesionsq ~ a T t !P:Ras protein signal transductionsq ~ T t P:cell-matrix adhesionsq ~ T t P:leukocyte adhesionsq ~ T t P:centrosome cyclesq ~ T t P:cell agingsq ~ T t P:visual perceptionsq ~ T t P:mitotic cell cycle checkpointsq ~ T t P:regulation of mitosissq ~ T t P:sensory perception of soundsq ~ T t -P:mitotic spindle organization and biogenesissq ~ T t )P:sensory perception of chemical stimulussq ~ T t
P:behaviorsq ~ uP T t P:lamellipodium biogenesissq ~ j T t P:microtubule-based movementsq ~ P T t !P:regulation of heart contractionsq ~ T t 0P:establishment and/or maintenance of cell po...sq ~ ] T t P:muscle developmentsq ~ T t P:axon guidancesq ~ Y T t P:activation of JNK activitysq ~ V T t
P:JNK cascadesq ~ c T t P:cell-cell signalingsq ~ d T t P:synaptic transmissionsq ~ k T t &P:multicellular organismal developmentsq ~ s T t P:spermatogenesissq ~ = T t %P:integrin-mediated signaling pathwaysq ~ T t 0P:negative regulation of adenylate cyclase ac...sq ~ T t P:single fertilizationsq ~ T t 0P:transforming growth factor beta receptor si...sq ~
T t 0P:transmembrane receptor protein serine/threo...sq ~ T t 0P:epidermal growth factor receptor signaling ...sq ~ T t P:signal complex assemblysq ~ T t 0P:transmembrane receptor protein tyrosine kin...sq ~ h T t P:cytoskeletal anchoringsq ~ T t 0P:regulation of actin polymerization and/or d...sq ~ ? T t ,P:DNA damage induced protein phosphorylationsq ~ T t "P:cellular calcium ion homeostasissq ~ i T t P:microtubule-based processsq ~ T t P:potassium ion transportsq ~ ! T t 0P:DNA damage response, signal transduction re...sq ~ J T t 'P:one-carbon compound metabolic processsq ~ T t P:ceramide metabolic processsq ~ T t P:sphingosine metabolic processsq ~ ! T t P:apoptotic programsq ~ T t +P:phosphatidylinositol biosynthetic processsq ~ T t P:fatty acid beta-oxidationsq ~ #[ T t +P:pentose-phosphate shunt, oxidative branchsq ~ T t /P:cotranslational protein targeting to membranesq ~ # T t "P:purine base biosynthetic processsq ~ T t +P:NLS-bearing substrate import into nucleussq ~ T t P:cellular iron ion homeostasissq ~ ! T t 0P:induction of apoptosis by intracellular sig...sq ~ T t (P:ER to Golgi vesicle-mediated transportsq ~ > T t !P:response to DNA damage stimulussq ~ < T t P:hyperosmotic responsesq ~ T t &P:establishment of blood-nerve barriersq ~ ) T t P:acute-phase responsesq ~ T t (P:negative regulation of DNA replicationsq ~ M T t %P:second-messenger-mediated signalingsq ~ T t P:muscle contractionsq ~ M
T t P:calcium-mediated signalingsq ~ Kg T t P:D-ribose catabolic processsq ~ ! T t P:male gonad developmentsq ~ ! T t 0P:induction of apoptosis by extracellular sig...sq ~ ! T t 0P:induction of apoptosis via death domain rec...sq ~ T t P:receptor-mediated endocytosissq ~ T t P:Golgi to endosome transportsq ~ T t P:protein import into nucleussq ~ T t %P:regulation of macrophage activationsq ~ T t P:bone resorptionsq ~ T t P:cell redox homeostasissq ~ T t $P:regulation of cell differentiationsq ~ T t #P:positive regulation of DNA repairsq ~ T t %P:positive regulation of angiogenesissq ~ E T t 0P:positive regulation of transcription, DNA-d...sq ~ k T t 0P:positive regulation of progression through ...sq ~ T t 0P:positive regulation of dopamine metabolic p...sq ~ T t 0P:positive regulation of smooth muscle contra...sq ~ T t P:hypoxanthine metabolic processsq ~ T t $P:negative regulation of JNK cascadesq ~ T t $P:positive regulation of JNK cascadesq ~ T t P:sphingoid catabolic processsq ~ T t P:regulation of transcriptionsq ~ / T t 0P:positive regulation of interferon-beta bios...sq ~ , T t 0P:positive regulation of interferon-alpha bio...sq ~ : T t "P:negative regulation of apoptosissq ~ = T t .P:negative regulation of programmed cell deathsq ~ r T t 0P:regulation of I-kappaB kinase/NF-kappaB cas...sq ~ x T t 0P:positive regulation of 1-phosphatidylinosit...sq ~ T t )P:negative regulation of caspase activitysq ~ T t 0P:proteasomal ubiquitin-dependent protein cat...sq ~ T t +P:regulation of protein complex disassemblysq ~ T t 'P:positive regulation of MAPKKK cascadesq ~ T t 0P:negative regulation of transcription factor...sq ~ T t P:histone exchangesq ~ T t 0P:positive regulation of interferon-gamma bio...sq ~ T t 0P:negative regulation of chemokine biosynthet...sq ~ T t P:cellular respirationsq ~ T t 0P:virion attachment, binding of host cell sur...sq ~ T t +P:mitochondrion transport along microtubulesq ~ ǝ T t P:regulation of DNA bindingsq ~ T t P:nuclear exportsq ~ T t P:telomere maintenancesq ~ T t (P:nuclear mRNA splicing, via spliceosomesq ~ Y T t P:protein homotetramerizationsq ~ T t P:protein polyubiquitinationsq ~ T t P:inactivation of MAPK activitysq ~ T t P:activation of MAPK activitysq ~ T t 0P:mRNA catabolic process, nonsense-mediated d...sq ~ T t P:MAPKKK cascadesq ~ T t P:stress-activated MAPK cascadesq ~ T t 0P:positive regulation of ubiquitin ligase act...sq ~ s T t 0P:S-phase-specific transcription in mitotic c...sq ~ T t P:skeletal developmentsq ~ T t P:regulation of cell growthsq ~ T t P:mesoderm formationsq ~ n T t %P:chaperonin-mediated tubulin foldingsq ~ T t 0P:positive regulation of fibroblast prolifera...sq ~ ' T t #P:regulation of synaptic plasticitysq ~ c T t 'P:plasma membrane to endosome transportsq ~ T t P:mRNA stabilizationsq ~ T t 0P:positive regulation of receptor mediated en...sq ~ T t 0P:negative regulation of receptor mediated en...sq ~ + T t 0P:positive regulation of peptidyl-tyrosine ph...sq ~ T t P:histone mRNA metabolic processsq ~ < T t ,P:protein import into nucleus, translocationsq ~ T t 0P:negative regulation of cytokine and chemoki...sq ~ - T t &P:epithelial to mesenchymal transitionsq ~ T t P:blastocyst developmentsq ~ O T t 0P:regulation of cyclin-dependent protein kina...sq ~ x T t P:unfolded protein responsesq ~ t T t P:B cell proliferationsq ~ T t )P:retrograde transport, endosome to Golgisq ~ x T t -P:retrograde protein transport, ER to cytosolsq ~ w T t P:neutrophil chemotaxissq ~ T t P:ribosome assemblysq ~ T t +P:natural killer cell mediated cytotoxicitysq ~ U T t P:regulation of phosphorylationsq ~ T t P:response to drugsq ~ w- T t P:BMP signaling pathwaysq ~ N T t 0P:long-term strengthening of neuromuscular ju...sq ~ T t ,P:negative regulation of histone acetylationsq ~ yR T t -P:positive regulation of histone modificationsq ~ y T t 0P:negative regulation of microtubule polymeri...sq ~ y T t P:rRNA pseudouridine synthesissq ~ z* T t /P:positive regulation of pseudopodium formationsq ~ ze T t 0P:negative regulation of protein complex asse...sq ~ {) T t $P:ruffle organization and biogenesissq ~ { T t 0P:negative regulation of lipopolysaccharide-m...sq ~ } T t 'P:activation of protein kinase activitysq ~ T t 0P:positive regulation of Rho protein signal t...sq ~ v T t 'P:positive regulation of cell migrationsq ~ vl T t P:osteoclast differentiationsq ~ vc T t $P:positive regulation of cell growthsq ~ T t P:defense response to bacteriumsq ~ vd T t $P:negative regulation of cell growthsq ~ T t P:cholesterol homeostasissq ~ u T t P:neuron differentiationsq ~ v T t P:macrophage differentiationsq ~ v] T t P:cholesterol transportsq ~ u T t P:platelet activationsq ~ vF T t P:regulation of ossificationsq ~ T t F:protein bindingsq ~ T t
F:RNA bindingsq ~ T t
F:ATP bindingsq ~ T t F:signal transducer activitysq ~ T t $F:structural constituent of ribosomesq ~ T
T t F:GTPase activitysq ~ NJ T t F:unfolded protein bindingsq ~ ] T t
F:DNA bindingsq ~ T t F:magnesium ion bindingsq ~ 2 T t F:identical protein bindingsq ~ T t F:receptor activitysq ~ A T t F:ATPase activitysq ~ T t #F:ubiquitin-protein ligase activitysq ~ T t (F:translation initiation factor activitysq ~ N T t F:zinc ion bindingsq ~ 3 T t #F:protein homodimerization activitysq ~ t T t F:transcription factor activitysq ~ o T t F:enzyme activator activitysq ~ T t F:calcium ion bindingsq ~ T t 0F:translation factor activity, nucleic acid b...sq ~ _ T t F:transporter activitysq ~ T t
F:GTP bindingsq ~ T t $F:transcription coactivator activitysq ~ T t %F:ATP-dependent RNA helicase activitysq ~ d T t F:MAP kinase kinase activitysq ~ B T t *F:protein serine/threonine kinase activitysq ~ T t $F:transcription corepressor activitysq ~ T t F:actin bindingsq ~ T t %F:ATP-dependent DNA helicase activitysq ~ P T t (F:structural constituent of cytoskeletonsq ~ T t )F:tumor necrosis factor receptor activitysq ~ q T t F:single-stranded DNA bindingsq ~ ! T t 0F:protein phosphatase type 2A regulator activitysq ~ i T t "F:protein-tyrosine kinase activitysq ~ V T t F:protein C-terminus bindingsq ~ w T t F:protein binding, bridgingsq ~ #_ T t F:electron carrier activitysq ~ T t %F:protein heterodimerization activitysq ~ e T t #F:MAP kinase kinase kinase activitysq ~ T t %F:translation release factor activitysq ~ A T t 0F:oxidoreductase activity, acting on NADH or ...sq ~ T t F:mRNA bindingsq ~ Y< T t &F:voltage-gated anion channel activitysq ~ S T t F:RNA cap bindingsq ~ T t F:3'-5' exonuclease activitysq ~ j T t F:double-stranded DNA bindingsq ~ !X T t F:Ran GTPase bindingsq ~ G T t F:actin filament bindingsq ~ M T t F:enzyme bindingsq ~ M T t F:protein kinase bindingsq ~ v T t 0F:RNA polymerase II transcription factor acti...sq ~ T t F:poly(A) bindingsq ~ u T t 'F:protein tyrosine phosphatase activitysq ~ + T t F:interleukin receptor activitysq ~ T t !F:transmembrane receptor activitysq ~ ! T t F:cytochrome-c oxidase activitysq ~ O T t F:endopeptidase activitysq ~ } T t "F:ubiquitin thiolesterase activitysq ~ T t F:ATPase activity, coupledsq ~ T t F:enoyl-CoA hydratase activitysq ~ T t "F:glutathione transferase activitysq ~ T t F:calmodulin bindingsq ~ @ T t F:protein kinase activitysq ~ e T t F:protein self-associationsq ~ T t F:SH2 domain bindingsq ~ ` T t $F:NF-kappaB-inducing kinase activitysq ~ B T t %F:G-protein coupled receptor activitysq ~ z T t F:ubiquitin bindingsq ~ Q T t F:microtubule bindingsq ~ N T t F:structural molecule activitysq ~ T t F:double-stranded RNA bindingsq ~ T t F:caspase inhibitor activitysq ~ @k T t F:oxidoreductase activitysq ~ u T t F:manganese ion bindingsq ~ v T t 0F:ligand-dependent nuclear receptor transcrip...sq ~ @ T t -F:specific transcriptional repressor activitysq ~ c T t 0F:electron transporter, transferring electron...sq ~ T t F:histone bindingsq ~ Ǐ T t F:chaperone bindingsq ~ 9 T t F:vitamin D receptor bindingsq ~ w3 T t F:snoRNA bindingsq ~ W T t
F:NAD bindingsq ~ u T t F:chaperone regulator activitysq ~ v{ T t F:estrogen receptor bindingsq ~ vB T t F:LIM domain bindingsq ~ A T t 0F:monodehydroascorbate reductase (NADH) activitysq ~ T t F:ribosome bindingsq ~ T t F:ATP-dependent protein bindingsq ~ B T t 'F:D-erythro-sphingosine kinase activitysq ~ @ T t "F:transcription activator activitysq ~ B T t $F:nucleoside-triphosphatase activitysq ~ @ T t "F:transcription repressor activitysq ~ w@ T t "F:transcription regulator activitysq ~ w_ T t 'F:rRNA pseudouridylation guide activitysq ~ 0 T t F:MHC class I protein bindingsq ~ M T t F:syntaxin bindingsq ~ T t F:S100 beta bindingsq ~ , T t #F:prostaglandin-E synthase activitysq ~ x T t F:Tat protein bindingsq ~ T t F:S100 alpha bindingsq ~ x T t "F:receptor tyrosine kinase bindingsq ~ T t #F:calcium-dependent protein bindingsq ~ g T t F:beta-tubulin bindingsq ~ NE T t F:heme bindingsq ~ v T t F:L-xylulose reductase activitysq ~ > T t *F:low-density lipoprotein receptor bindingsq ~ T t
F:FAD bindingsq ~ T t F:androgen receptor bindingsq ~ M T t F:phosphatase bindingsq ~ x T t F:GTP-dependent protein bindingsq ~ u T t F:ADP reductase activitysq ~ J T t "F:ADP-sugar diphosphatase activitysq ~ K T t F:nucleoside kinase activitysq ~ w T t F:caspase activitysq ~ ʧ T t F:Hsp90 protein bindingsq ~ s T t F:NF-kappaB bindingsq ~ ~ T t F:MutLalpha complex bindingsq ~ | T t *F:N-terminal myristoylation domain bindingsq ~ {+ T t 0F:thyrotropin-releasing hormone receptor bindingsq ~ T t F:metal ion bindingsq ~ B T t F:microtubule plus-end bindingsq ~ v T t "F:thyroid hormone receptor bindingsq ~ y T t 0F:RNA splicing factor activity, transesterifi...sq ~ T t F:CARD domain bindingsq ~ " T t 0F:phosphoribosylformylglycinamidine synthase ...sq ~ T t F:valine-tRNA ligase activitysq ~ T t &F:ubiquitin activating enzyme activitysq ~ T t &F:ubiquitin-specific protease activitysq ~ T t #F:uracil DNA N-glycosylase activitysq ~ T t F:enzyme inhibitor activitysq ~ T t #F:protein kinase inhibitor activitysq ~ T t (F:protein phosphatase inhibitor activitysq ~ - T t 0F:interleukin-1, Type I, activating receptor ...sq ~ T t F:tyrosine-tRNA ligase activitysq ~ T t F:threonine-tRNA ligase activitysq ~ T t !F:methionine-tRNA ligase activitysq ~ # T t 0F:phosphoribosylaminoimidazolecarboxamide for...sq ~ V T t 0F:eukaryotic translation initiation factor 2a...sq ~ \ T t $F:atypical protein kinase C activitysq ~ o T t 0F:protein-L-isoaspartate (D-aspartate) O-meth...sq ~ { T t *F:purine-nucleoside phosphorylase activitysq ~ T t F:transaldolase activitysq ~ T t F:glycine-tRNA ligase activitysq ~ T t F:histidine-tRNA ligase activitysq ~ T t F:transferrin receptor activitysq ~ T t .F:insulin-like growth factor receptor activitysq ~ T t .F:delayed rectifier potassium channel activitysq ~ T t &F:calcium-transporting ATPase activitysq ~ p T t F:bindingsq ~ x T t F:steroid bindingsq ~ T t F:fatty acid bindingsq ~ T t F:copper ion bindingsq ~ T t F:collagen bindingsq ~ T t F:hyaluronic acid bindingsq ~ : T t F:integrin bindingsq ~ , T t (F:tumor necrosis factor receptor bindingsq ~ ! T t F:interleukin-8 receptor bindingsq ~ T t %F:receptor signaling protein activitysq ~ T t F:SH3/SH2 adaptor activitysq ~ T t !F:small GTPase regulator activitysq ~ T t %F:GDP-dissociation inhibitor activitysq ~ T t )F:Rab GDP-dissociation inhibitor activitysq ~ T t F:Ran GTPase activator activitysq ~ T t F:receptor bindingsq ~ T t F:cytokine activitysq ~ T t /F:phosphatidylinositol-4,5-bisphosphate bindingsq ~ 1 T t F:tRNA bindingsq ~ T t F:6-phosphofructokinase activitysq ~ + T t F:CTP synthase activitysq ~ ; T t &F:DNA-directed RNA polymerase activitysq ~ B T t 0F:DNA-(apurinic or apyrimidinic site) lyase a...sq ~ a T t F:IMP cyclohydrolase activitysq ~ n T t &F:NAD+ ADP-ribosyltransferase activitysq ~ T t )F:acetyl-CoA C-acetyltransferase activitysq ~ T t ,F:adenine phosphoribosyltransferase activitysq ~ T t F:antigen bindingsq ~ T t F:microtubule motor activitysq ~ T t &F:protein disulfide isomerase activitysq ~ ^ T t F:DNA helicase activitysq ~ d T t F:damaged DNA bindingsq ~ x T t 0F:specific RNA polymerase II transcription fa...sq ~ y T t 0F:RNA polymerase II transcription factor acti...sq ~ T t !F:transcription cofactor activitysq ~ T t F:telomerase activitysq ~ T t (F:translation elongation factor activitysq ~ T t .F:peptidyl-prolyl cis-trans isomerase activitysq ~ T t !F:adenosylhomocysteinase activitysq ~ T t F:adenylate kinase activitysq ~ k T t "F:L-lactate dehydrogenase activitysq ~ } T t 0F:methenyltetrahydrofolate cyclohydrolase act...sq ~ ~ T t )F:methionine adenosyltransferase activitysq ~ T t 0F:methylenetetrahydrofolate dehydrogenase act...sq ~ T t F:endodeoxyribonuclease activitysq ~ T t F:ribonuclease H activitysq ~ T t F:phosphodiesterase I activitysq ~ T t *F:ornithine-oxo-acid transaminase activitysq ~ F T t 0F:hypoxanthine phosphoribosyltransferase acti...sq ~ ! T t F:guanylate kinase activitysq ~
T t 0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq ~ T t F:aldehyde reductase activitysq ~ T t %F:carbonyl reductase (NADPH) activitysq ~ T t F:citrate (Si)-synthase activitysq ~ Q T t F:aminopeptidase activitysq ~ e T t &F:cysteine-type endopeptidase activitysq ~ T t F:prolyl oligopeptidase activitysq ~ T t *F:formate-tetrahydrofolate ligase activitysq ~ T t "F:glutamate dehydrogenase activitysq ~ T t 0F:phosphoribosylaminoimidazolesuccinocarboxam...sq ~ : T t +F:protein disulfide oxidoreductase activitysq ~ !. T t F:translation activator activitysq ~ ; T t /F:mevalonate transmembrane transporter activitysq ~ ! T t F:caspase activator activitysq ~ m T t F:DNA bending activitysq ~ # T t 'F:phosphohistidine phosphatase activitysq ~ : T t &F:protein phosphatase type 2C activitysq ~ T t "F:phospholipase inhibitor activitysq ~ !! T t F:sphinganine kinase activitysq ~ <} T t F:cholesterol bindingsq ~ !& T t 0F:diphosphoinositol-polyphosphate diphosphata...sq ~ @G T t 0F:RNA polymerase II transcription mediator ac...sq ~ T t F:N-methyltransferase activitysq ~ T t *F:3-hydroxyacyl-CoA dehydrogenase activitysq ~ T t 'F:nuclear localization sequence bindingsq ~ T t F:MP kinase activitysq ~ T t F:carboxylesterase activitysq ~ T t .F:3'(2'),5'-bisphosphate nucleotidase activitysq ~ ?P T t
F:AMP bindingsq ~ : T t #F:disulfide oxidoreductase activitysq ~ 4 T t C:nucleussq ~ i . T t C:cytoplasmsq ~ T t &C:proteasome complex (sensu Eukaryota)sq ~ T t C:integral to plasma membranesq ~ T t C:endoplasmic reticulumsq ~
T t C:cytosolsq ~ k T t C:mitochondrionsq ~ T t C:soluble fractionsq ~ T t C:intracellularsq ~ b T t C:nucleolussq ~ T t 0C:cytosolic large ribosomal subunit (sensu Eu...sq ~ T t C:plasma membranesq ~ ' T t C:cell surfacesq ~ > T t
C:membranesq ~ T t 0C:proteasome regulatory particle (sensu Eukar...sq ~ W T t !C:perinuclear region of cytoplasmsq ~ T t C:cytoskeletonsq ~ T t 0C:cytosolic small ribosomal subunit (sensu Eu...sq ~ > T t C:integral to membranesq ~ T t C:mitochondrial matrixsq ~ T t C:nuclear poresq ~ T t C:endoplasmic reticulum lumensq ~ T t 0C:eukaryotic translation initiation factor 3 ...sq ~ T t
C:microtubulesq ~ T t C:membrane fractionsq ~ =
T t C:actin cytoskeletonsq ~ T t C:Arp2/3 protein complexsq ~ T t %C:protein phosphatase type 2A complexsq ~ T t
C:endosomesq ~ T t C:extracellular regionsq ~ T t C:ubiquitin ligase complexsq ~ T t C:extracellular spacesq ~ T t C:endoplasmic reticulum membranesq ~ ? T t 0C:eukaryotic translation initiation factor 4F...sq ~ b T t !C:F-actin capping protein complexsq ~ z T t C:UBC13-MMS2 complexsq ~ T t (C:NuA4 histone acetyltransferase complexsq ~ T t C:rufflesq ~ T t
C:polysomesq ~ T t C:microsomesq ~ = T t C:microtubule cytoskeletonsq ~ T t #C:ER-Golgi intermediate compartmentsq ~ > T t $C:cytoplasmic membrane-bound vesiclesq ~ wB T t 0C:heterogeneous nuclear ribonucleoprotein com...sq ~ T t C:centrosomesq ~ y T t 0C:mitochondrial proton-transporting ATP synth...sq ~ T t +C:proteasome core complex (sensu Eukaryota)sq ~ T t C:stress fibersq ~ m T t C:mitochondrial outer membranesq ~ T t
C:kinetochoresq ~ @ T t C:sarcoplasmic reticulumsq ~ w T t C:mediator complexsq ~ T t C:Golgi membranesq ~ # T t C:transcription factor complexsq ~ T t C:condensed nuclear chromosomesq ~ M T t C:extrinsic to membranesq ~ T t C:condensed chromosomesq ~ T t C:nuclear chromosomesq ~ T t C:chromatinsq ~
T t C:chromosome, telomeric regionsq ~ @ T t C:caveolar membranesq ~ T t "C:DNA replication factor C complexsq ~ ; T t
C:MCM complexsq ~ o T t C:mitochondrial inner membranesq ~ y T t #C:cortical microtubule cytoskeletonsq ~ ~ T t #C:mitochondrial intermembrane spacesq ~ T t 'C:mitochondrial large ribosomal subunitsq ~ x T t C:cortical cytoskeletonsq ~ T t
C:lysosomesq ~ T t C:late endosomesq ~ A T t C:telomerase holoenzyme complexsq ~ 1 T t
C:spliceosomesq ~ T t &C:alpha DNA polymerase:primase complexsq ~ ~ T t
C:CBM complexsq ~ T t
C:nucleoplasmsq ~ T t C:nuclear envelopesq ~ u T t C:T cell receptor complexsq ~ T t C:insoluble fractionsq ~ T t C:paraspecklessq ~ . T t C:chromatin assembly complexsq ~ wA T t C:ribonucleoprotein complexsq ~ T t C:protein complexsq ~ d T t +C:small nucleolar ribonucleoprotein complexsq ~ T t C:actin filamentsq ~ u T t 'C:trans-Golgi network transport vesiclesq ~ u T t .C:clathrin coat of trans-Golgi network vesiclesq ~ u T t C:COPI vesicle coatsq ~ u T t C:AP-2 adaptor complexsq ~ T t
C:microvillussq ~ 9 T t C:6-phosphofructokinase complexsq ~ T t )C:voltage-gated potassium channel complexsq ~ u T t C:filopodiumsq ~ u T t ,C:integral to endoplasmic reticulum membranesq ~ T t C:Golgi apparatussq ~ T t C:trans-Golgi networksq ~ A T t C:lipid raftsq ~ T t C:interleukin-1 receptor complexsq ~ T t
C:ribosomesq ~ @U T t /C:proton-transporting two-sector ATPase complexsq ~ T t 0C:eukaryotic translation elongation factor 1 ...sq ~ T t C:cytoplasmic dynein complexsq ~ R T t C:pore complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ T t )P:activation of NF-kappaB-inducing kinaset 7250sq ~ T t 0P:positive regulation of I-kappaB kinase/NF-k...t 43123sq ~ T t *P:positive regulation of T cell activationt 50870sq ~ T t 0P:positive regulation of T cell cytokine prod...t 2726sq ~ T t P:protein polyubiquitinationt 209sq ~ T t #P:T cell receptor signaling pathwayt 50852sq ~ T t F:protein bindingt 5515sq ~ T t F:signal transducer activityt 4871sq ~ T t #F:ubiquitin-protein ligase activityt 4842pxsq ~ uq ~
sq ~ Tt IPR002083t MATHsq ~ Tt IPR012227t TNF_recpt_TRAFsq ~ Tt IPR013322t TRAF-typesq ~ Tt IPR001841t Znf_RINGsq ~ Tt IPR001293t Znf_TRAFpppppxsq ~ uq ~
sq ~ Tt MATHt PF00917sq ~ Tt zf-C3HC4t PF00097sq ~ Tt zf-TRAFt PF02176pppppppxt Q9Y4K3t TRAF6_HUMANsq ~ uq ~
sq ~ Tt Interleukin-1 signal transducersq ~ Tt RING finger protein 85ppppppppxt Homo sapienst EGR1sq ~?// %t Early growth response protein 1sq ~ uq ~
sq ~ t ENSG00000120738pppppppppxsq ~ uq ~
sq ~ t EGR1sq ~ t ZNF225ppppppppxsq ~ Puq ~
Psq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t P:signal transductionsq ~ ` t P:homeostatic processsq ~ [ t P:cell proliferationsq ~ t P:nervous system developmentsq ~ F t (P:N-terminal peptidyl-lysine acetylationsq ~ t P:response to hypoxiasq ~ u t &P:positive regulation of transcriptionsq ~ t P:cell agingsq ~ t P:protein localizationsq ~ ɗ t P:defense response to virussq ~ k t &P:multicellular organismal developmentsq ~ t P:cell cycle arrestsq ~ G t P:ER overload responsesq ~ 8 t P:cellular defense responsesq ~ + t P:immune responsesq ~ * t P:inflammatory responsesq ~ ! t %P:caspase activation via cytochrome csq ~ % t $P:anatomical structure morphogenesissq ~ '1 t P:response to organic substancesq ~ > t P:protein tetramerizationsq ~ Ǚ t *P:negative regulation of helicase activitysq ~ ǔ t .P:activation of NF-kappaB transcription factorsq ~ Ǔ t 0P:positive regulation of transcription factor...sq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ t 0P:positive regulation of global transcription...sq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ t 0P:DNA damage response, signal transduction by...sq ~ t )P:cellular response to glucose starvationsq ~ K t 0P:cytokine and chemokine mediated signaling p...sq ~ @ t P:histone acetylationsq ~ ' t P:response to UV-Bsq ~ ) t P:acute-phase responsesq ~ t P:anti-apoptosissq ~ vd t $P:negative regulation of cell growthsq ~ t P:skeletal developmentsq ~ t P:base-excision repairsq ~ t P:nucleotide-excision repairsq ~ t /P:transcription from RNA polymerase II promotersq ~ = t P:protein complex assemblysq ~ D t $P:protein amino acid phosphorylationsq ~ t P:apoptosissq ~ t t F:transcription factor activitysq ~ t F:protein bindingsq ~ } t F:protein N-terminus bindingsq ~ t $F:transcription coactivator activitysq ~ v t 0F:RNA polymerase II transcription factor acti...sq ~ 2 t $F:histone acetyltransferase activitysq ~ @ t "F:transcription activator activitysq ~ t F:signal transducer activitysq ~ V t F:protein C-terminus bindingsq ~ 2 t F:identical protein bindingsq ~ 3 t #F:protein homodimerization activitysq ~ - t F:sequence-specific DNA bindingsq ~ y t 0F:RNA polymerase II transcription factor acti...sq ~ t
F:ATP bindingsq ~ t %F:protein heterodimerization activitysq ~ s t F:NF-kappaB bindingsq ~ = t F:phosphate bindingsq ~ t F:DNA strand annealing activitysq ~ y t F:MyoD bindingsq ~ t $F:transcription corepressor activitysq ~ N t F:zinc ion bindingsq ~ t F:copper ion bindingsq ~ M t F:enzyme bindingsq ~ M t F:protein kinase bindingsq ~ J t F:protein kinase CK2 activitysq ~ t F:nuclease activitysq ~ @ t "F:transcription repressor activitysq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:insoluble fractionsq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:plasma membranesq ~ t
C:nucleoplasmsq ~ k t C:mitochondrionsq ~ ? t C:nuclear matrixsq ~ # t C:transcription factor complexsq ~ b t C:nucleolussq ~ t C:nuclear chromosomexsq ~ uq ~
sq ~ t &P:positive regulation of transcriptiont 45941sq ~ t F:transcription factor activityt 3700sq ~ t C:nucleust 5634pppppppxsq ~ uq ~
sq ~ t IPR007087t Znf_C2H2pppppppppxsq ~ uq ~
sq ~ t zf-C2H2t PF00096pppppppppxt P18146t
EGR1_HUMANsq ~ uq ~
sq ~ t EGR-1sq ~ t Protein Krox-24sq ~ t Transcription factor Zif268sq ~ t %Nerve growth factor-induced protein Asq ~ t NGFI-Asq ~ t Transcription factor ETR103sq ~ t Zinc finger protein 225sq ~ t AT225ppxt Homo sapienst PSB6sq ~? & %t (Proteasome subunit beta type-6 precursorsq ~ uq ~
sq ~ &t ENSG00000142507pppppppppxsq ~ uq ~
sq ~ & t PSMB6sq ~ & t LMPYppppppppxsq ~ *uq ~
Psq ~ s & t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ J & t .P:regulation of progression through cell cyclesq ~ & t ,P:regulation of transcription, DNA-dependentsq ~ & t P:mitosissq ~ D & t $P:protein amino acid phosphorylationsq ~ l & t
P:proteolysissq ~ & t P:anti-apoptosissq ~ + & t P:immune responsesq ~ R & t )P:activation of NF-kappaB-inducing kinasesq ~ [ & t P:cell proliferationsq ~ & t P:protein polyubiquitinationsq ~ ƶ & t *P:positive regulation of T cell activationsq ~
& t 0P:positive regulation of T cell cytokine prod...sq ~ Ƥ & t #P:T cell receptor signaling pathwaysq ~ & t P:rRNA processingsq ~ & t )P:negative regulation of caspase activitysq ~ & t 0P:establishment and/or maintenance of chromat...sq ~ & t F:protein bindingsq ~ & t
F:RNA bindingsq ~ & t
F:ATP bindingsq ~ A & t F:ATPase activitysq ~ w & t F:protein binding, bridgingsq ~ ` & t $F:NF-kappaB-inducing kinase activitysq ~ & t F:caspase inhibitor activitysq ~ NJ & t F:unfolded protein bindingsq ~ & t #F:ubiquitin-protein ligase activitysq ~ & t F:signal transducer activitysq ~ B & t *F:protein serine/threonine kinase activitysq ~ & t F:calcium ion bindingsq ~ ] & t
F:DNA bindingsq ~ F & t $F:histone methyltransferase activitysq ~ & t &C:proteasome complex (sensu Eukaryota)sq ~ & t C:nucleussq ~ W & t !C:perinuclear region of cytoplasmsq ~ & t C:ESC/E(Z) complexsq ~ & t
C:polysomesq ~ ' & t C:cell surfacesq ~ & t #C:ER-Golgi intermediate compartmentsq ~ i & t C:cytoplasmsq ~ & t C:endoplasmic reticulum lumensq ~ & t C:centrosomesq ~ u & t ,C:integral to endoplasmic reticulum membraneppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ & t /P:ubiquitin-dependent protein catabolic processt 6511sq ~ & t F:endopeptidase activityt 4175sq ~ & t +C:proteasome core complex (sensu Eukaryota)t 5839pppppppxsq ~ uq ~
sq ~ &t IPR000243t
Pept_T1A_subBsq ~ &t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ &t
Proteasomet PF00227pppppppppxt P28072t
PSB6_HUMANsq ~ uq ~
sq ~ &t Proteasome delta chainsq ~ &t Macropain delta chainsq ~ &t 0Multicatalytic endopeptidase complex delta chainsq ~ &t Proteasome subunit Yppppppxt Homo sapienst PSB5sq ~?lJ ' %t (Proteasome subunit beta type-5 precursorsq ~ uq ~
sq ~ 't ENSG00000100804pppppppppxsq ~ uq ~
sq ~ ' t PSMB5sq ~ ' t LMPXppppppppxsq ~ Euq ~
Psq ~ J ' t .P:regulation of progression through cell cyclesq ~ ] ' t +P:negative regulation of cell proliferationsq ~ s ' t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ ƶ ' t *P:positive regulation of T cell activationsq ~ * ' t P:inflammatory responsesq ~ & ' t P:response to stresssq ~ ' t P:anti-apoptosissq ~ ' t P:apoptosissq ~ o ' t /P:ubiquitin-dependent protein catabolic processsq ~ n ' t P:ATP-dependent proteolysissq ~ l ' t
P:proteolysissq ~ ' t P:alanyl-tRNA aminoacylationsq ~ ' t P:mRNA processingsq ~ ' t 0P:RNA elongation from RNA polymerase II promotersq ~ J ' t P:response to unfolded proteinsq ~ R ' t )P:activation of NF-kappaB-inducing kinasesq ~ Ƥ ' t #P:T cell receptor signaling pathwaysq ~ ƅ ' t P:protein stabilizationsq ~ ' t -P:positive regulation of cell differentiationsq ~ u ' t 0P:positive regulation of nitric oxide biosynt...sq ~ ' t P:proteasome assemblysq ~ uT ' t 0P:actin cytoskeleton organization and biogenesissq ~ ' t P:RNA splicingsq ~ [ ' t P:cell proliferationsq ~ a ' t P:tRNA processingsq ~ O ' t
P:circulationsq ~ ' t ,P:regulation of transcription, DNA-dependentsq ~ @ ' t P:protein ubiquitinationsq ~ ' t P:cell morphogenesissq ~
' t 0P:positive regulation of T cell cytokine prod...sq ~ ' t P:mitosissq ~ ' t P:protein polyubiquitinationsq ~ z ' t 0P:negative regulation of transcription from R...sq ~
' t F:protein bindingsq ~ ' t F:signal transducer activitysq ~ B ' t *F:protein serine/threonine kinase activitysq ~ !Z ' t F:proteasome activator activitysq ~ ' t
F:RNA bindingsq ~ O ' t F:endopeptidase activitysq ~ 1 ' t F:tRNA bindingsq ~ A ' t F:ATPase activitysq ~ t ' t F:transcription factor activitysq ~ v ' t *F:nitric-oxide synthase regulator activitysq ~ vB ' t F:LIM domain bindingsq ~ x ' t F:TPR domain bindingsq ~ ' t $F:transcription coactivator activitysq ~ ' t F:CARD domain bindingsq ~ P ' t (F:structural constituent of cytoskeletonsq ~ ' t F:transcription factor bindingsq ~ ' t #F:ubiquitin-protein ligase activitysq ~ y ' t 0F:RNA splicing factor activity, transesterifi...sq ~ ' t F:phosphatidylinositol bindingsq ~
' t &C:proteasome complex (sensu Eukaryota)sq ~ ' t C:nucleussq ~ i ' t C:cytoplasmsq ~ ' t C:soluble fractionsq ~ ' t C:plasma membranesq ~ ' t C:integral to plasma membranesq ~ ' t 0C:proteasome regulatory particle (sensu Eukar...sq ~ ' t
C:spectrinsq ~ ' t C:cytosolsq ~ ' t +C:proteasome core complex (sensu Eukaryota)sq ~ ' t C:protein complexsq ~ ' t C:centrosomesq ~ ' t C:Bcl3/NF-kappaB2 complexsq ~ ' t C:membrane fractionsq ~ k ' t C:mitochondrionsq ~ ' t
C:polysomesq ~ ' t C:endoplasmic reticulumpppppppppppxsq ~ uq ~
sq ~ ' t F:protein bindingt 5515sq ~ ' t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ 't IPR000243t
Pept_T1A_subBsq ~ 't IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ 't
Proteasomet PF00227pppppppppxt P28074t
PSB5_HUMANsq ~ uq ~
sq ~ 't Proteasome epsilon chainsq ~ 't Macropain epsilon chainsq ~ 't 2Multicatalytic endopeptidase complex epsilon chainsq ~ 't Proteasome subunit Xsq ~ 't Proteasome chain 6sq ~ 't Proteasome subunit MB1ppppxt Homo sapienst PSB10sq ~?mm %t )Proteasome subunit beta type-10 precursorsq ~ uq ~
sq ~ t ENSG00000205220pppppppppxsq ~ uq ~
sq ~ t PSMB10sq ~ t MECL1ppppppppxsq ~ uq ~
sq ~ \ t +P:positive regulation of cell proliferationsq ~ t P:nervous system developmentsq ~ t 0P:transmembrane receptor protein tyrosine pho...sq ~ t F:protein bindingsq ~ t
F:RNA bindingsq ~ t (F:protein phosphatase inhibitor activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ t C:endoplasmic reticulumsq ~ t
C:polysomesq ~ t C:extracellular spacesq ~ i t C:cytoplasmppppppppxsq ~ uq ~
sq ~ t P:humoral immune responset 6959sq ~ t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ t IPR000243t
Pept_T1A_subBsq ~ t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt P40306t PSB10_HUMANsq ~ uq ~
sq ~ t Proteasome subunit beta-2isq ~ t Proteasome MECl-1sq ~ t Macropain subunit MECl-1sq ~ t 3Multicatalytic endopeptidase complex subunit MECl-1ppppppxt Homo sapienst PSB4sq ~? Q %t (Proteasome subunit beta type-4 precursorsq ~ uq ~
sq ~ Qt ENSG00000159377pppppppppxsq ~ uq ~
sq ~ Q t PSMB4pppppppppxsq ~ /uq ~
Psq ~ s Q t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ & Q t !P:embryonic pattern specificationsq ~ # Q t .P:nucleoside triphosphate biosynthetic processsq ~ ] Q t +P:negative regulation of cell proliferationsq ~ Q t P:mitosissq ~ [ Q t P:cell proliferationsq ~ R Q t )P:activation of NF-kappaB-inducing kinasesq ~ Q t 0P:transforming growth factor beta receptor si...sq ~ Q t P:cell adhesionsq ~ + Q t P:immune responsesq ~ Q t ,P:regulation of transcription, DNA-dependentsq ~ D Q t $P:protein amino acid phosphorylationsq ~ J Q t .P:regulation of progression through cell cyclesq ~ o Q t /P:ubiquitin-dependent protein catabolic processsq ~ Q t P:protein polyubiquitinationsq ~ Ƥ Q t #P:T cell receptor signaling pathwaysq ~ Q t 0P:positive regulation of epithelial cell prol...sq ~
Q t 0P:positive regulation of T cell cytokine prod...sq ~ ƶ Q t *P:positive regulation of T cell activationsq ~ r Q t %P:regulation of epidermis developmentsq ~ 2 Q t 0P:positive regulation of keratinocyte differe...sq ~ : Q t "P:negative regulation of apoptosissq ~ w- Q t P:BMP signaling pathwaysq ~ Q t F:protein bindingsq ~ Q t
F:RNA bindingsq ~ Q t
F:ATP bindingsq ~ @ Q t "F:transcription activator activitysq ~ t Q t F:transcription factor activitysq ~ Q t $F:transcription coactivator activitysq ~ Q t $F:transcription corepressor activitysq ~ O Q t F:endopeptidase activitysq ~ Q t (F:nucleoside diphosphate kinase activitysq ~ B Q t *F:protein serine/threonine kinase activitysq ~ ` Q t $F:NF-kappaB-inducing kinase activitysq ~ Q t #F:ubiquitin-protein ligase activitysq ~ Q t F:signal transducer activitysq ~ Q t %F:receptor signaling protein activitysq ~ Q t &C:proteasome complex (sensu Eukaryota)sq ~ Q t C:nucleussq ~ Q t C:centrosomesq ~ Q t 0C:proteasome regulatory particle (sensu Eukar...sq ~ uK Q t C:lamellipodiumsq ~ Q t +C:proteasome core complex (sensu Eukaryota)sq ~ Q t
C:polysomesq ~ Q t C:rufflesq ~ i Q t C:cytoplasmsq ~ > Q t C:integral to membranepppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ Q t C:nucleust 5634sq ~ Q t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ Qt IPR000243t
Pept_T1A_subBsq ~ Qt IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ Qt
Proteasomet PF00227pppppppppxt P28070t
PSB4_HUMANsq ~ uq ~
sq ~ Qt Proteasome beta chainsq ~ Qt Macropain beta chainsq ~ Qt /Multicatalytic endopeptidase complex beta chainsq ~ Qt Proteasome chain 3sq ~ Qt HSN3sq ~ Qt HsBPROS26ppppxt Homo sapienst PSB3sq ~?m:Ӡs % %t Proteasome subunit beta type-3sq ~ uq ~
sq ~ %t ENSG00000108294pppppppppxsq ~ uq ~
sq ~ % t PSMB3pppppppppxsq ~ 5uq ~
Psq ~ % t P:signal transductionsq ~ % t P:anti-apoptosissq ~ J % t .P:regulation of progression through cell cyclesq ~ s % t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ n % t P:ATP-dependent proteolysissq ~ l % t
P:proteolysissq ~ D % t $P:protein amino acid phosphorylationsq ~ + % t P:immune responsesq ~ / % t P:humoral immune responsesq ~ % t P:mitosissq ~ o % t /P:ubiquitin-dependent protein catabolic processsq ~ R % t )P:activation of NF-kappaB-inducing kinasesq ~ O % t
P:circulationsq ~ Ƥ % t #P:T cell receptor signaling pathwaysq ~ ƅ % t P:protein stabilizationsq ~ % t -P:positive regulation of cell differentiationsq ~ @ % t P:protein ubiquitinationsq ~ = % t P:glucose transportsq ~ ] % t +P:negative regulation of cell proliferationsq ~ [ % t P:cell proliferationsq ~ ƶ % t *P:positive regulation of T cell activationsq ~ . % t (P:regulation of translational initiationsq ~
% t 0P:positive regulation of T cell cytokine prod...sq ~ z % t 0P:negative regulation of transcription from R...sq ~ % t P:protein polyubiquitinationsq ~ % t P:cell morphogenesissq ~ & % t P:response to stresssq ~ uT % t 0P:actin cytoskeleton organization and biogenesissq ~ % t F:protein bindingsq ~ % t F:transcription factor bindingsq ~ A % t F:ATPase activitysq ~ B % t *F:protein serine/threonine kinase activitysq ~ ` % t $F:NF-kappaB-inducing kinase activitysq ~ O % t F:endopeptidase activitysq ~ % t #F:ubiquitin-protein ligase activitysq ~ % t F:signal transducer activitysq ~ % t F:receptor activitysq ~ % t !F:growth hormone receptor bindingsq ~ ; % t F:hormone activitysq ~ P % t (F:structural constituent of cytoskeletonsq ~ % t
F:ATP bindingsq ~ % t F:phosphatidylinositol bindingsq ~
% t &C:proteasome complex (sensu Eukaryota)sq ~ % t C:nucleussq ~ i % t C:cytoplasmsq ~ k % t C:mitochondrionsq ~ % t C:endoplasmic reticulumsq ~ % t C:plasma membranesq ~ % t C:protein complexsq ~ % t
C:spectrinsq ~ % t +C:proteasome core complex (sensu Eukaryota)sq ~ % t C:cytosolsq ~ % t C:centrosomepppppppppppppppppppppppppppxsq ~ uq ~
sq ~ % t F:protein bindingt 5515sq ~ % t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ %t IPR000243t
Pept_T1A_subBsq ~ %t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ %t
Proteasomet PF00227pppppppppxt P49720t
PSB3_HUMANsq ~ uq ~
sq ~ %t Proteasome theta chainsq ~ %t Proteasome chain 13sq ~ %t Proteasome component C10-IIpppppppxt Homo sapienst PSB2sq ~?333333
%t Proteasome subunit beta type-2sq ~ uq ~
sq ~ t ENSG00000126067pppppppppxsq ~ uq ~
sq ~ t PSMB2pppppppppxsq ~ uq ~
sq ~ J t .P:regulation of progression through cell cyclesq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ [ t P:cell proliferationsq ~ R t )P:activation of NF-kappaB-inducing kinasesq ~ t P:mitosissq ~ ƶ t *P:positive regulation of T cell activationsq ~ t P:protein polyubiquitinationsq ~
t 0P:positive regulation of T cell cytokine prod...sq ~ t F:protein bindingsq ~ t F:signal transducer activitysq ~ t
F:RNA bindingsq ~ B t *F:protein serine/threonine kinase activitysq ~ t #F:ubiquitin-protein ligase activitysq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ t C:nucleussq ~ t
C:polysomesq ~ t C:centrosomesq ~ i t C:cytoplasmpxsq ~ uq ~
sq ~ t &C:proteasome complex (sensu Eukaryota)t 502pppppppppxsq ~ uq ~
sq ~ t IPR000243t
Pept_T1A_subBsq ~ t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ t
Proteasomet PF00227pppppppppxt P49721t
PSB2_HUMANsq ~ uq ~
sq ~ t Proteasome component C7-Isq ~ t Macropain subunit C7-Isq ~ t 1Multicatalytic endopeptidase complex subunit C7-Ipppppppxt Homo sapienst PSB1sq ~?99 $ ( $ %t (Proteasome subunit beta type-1 precursorsq ~ uq ~
sq ~ (t ENSG00000008018pppppppppxsq ~ uq ~
sq ~ ( t PSMB1sq ~ ( t PSC5ppppppppxsq ~ Cuq ~
Psq ~ o ( t /P:ubiquitin-dependent protein catabolic processsq ~ J ( t .P:regulation of progression through cell cyclesq ~ D ( t $P:protein amino acid phosphorylationsq ~ l ( t
P:proteolysissq ~ ( t P:anti-apoptosissq ~ + ( t P:immune responsesq ~ [ ( t P:cell proliferationsq ~ ( t P:cell adhesionsq ~ ( t P:mitosissq ~ & ( t P:response to stresssq ~ ( t P:induction of apoptosissq ~ ( t 0P:regulation of transcription from RNA polyme...sq ~ ( t ,P:regulation of transcription, DNA-dependentsq ~ ( t P:cell-matrix adhesionsq ~ ( t 0P:cell surface receptor linked signal transdu...sq ~ ( t -P:positive regulation of cell differentiationsq ~ ! ( t P:apical junction assemblysq ~ s ( t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ uT ( t 0P:actin cytoskeleton organization and biogenesissq ~ uP ( t P:lamellipodium biogenesissq ~ @ ( t P:protein ubiquitinationsq ~ ] ( t +P:negative regulation of cell proliferationsq ~ \ ( t +P:positive regulation of cell proliferationsq ~ ƅ ( t P:protein stabilizationsq ~ O ( t
P:circulationsq ~ = ( t %P:integrin-mediated signaling pathwaysq ~ ( t P:DNA repairsq ~ v ( t 'P:negative regulation of cell migrationsq ~ K ( t P:cell cycle checkpointsq ~ z ( t 0P:negative regulation of transcription from R...sq ~ ( t P:chromosome segregationsq ~ ( t P:cell morphogenesissq ~ ( t F:protein bindingsq ~ O ( t F:endopeptidase activitysq ~ ( t
F:RNA bindingsq ~ ( t
F:ATP bindingsq ~ B ( t *F:protein serine/threonine kinase activitysq ~ ( t F:transcription factor bindingsq ~ ) ( t F:peptidase activitysq ~ ( t $F:transcription coactivator activitysq ~ @k ( t F:oxidoreductase activitysq ~ t ( t F:transcription factor activitysq ~ d ( t F:damaged DNA bindingsq ~ 2 ( t F:identical protein bindingsq ~ ( t F:alpha-catenin bindingsq ~ ` ( t $F:NF-kappaB-inducing kinase activitysq ~ ( t )F:tumor necrosis factor receptor activitysq ~ P ( t (F:structural constituent of cytoskeletonsq ~ ( t $F:transcription corepressor activitysq ~ ( t F:phosphatidylinositol bindingsq ~ ( t &C:proteasome complex (sensu Eukaryota)sq ~ ( t C:nucleussq ~ ( t +C:proteasome core complex (sensu Eukaryota)sq ~ ( t C:protein complexsq ~ ( t C:cytosolsq ~ i ( t C:cytoplasmsq ~ % ( t C:focal adhesionsq ~ ( t C:intercellular junctionsq ~ ( t C:integral to plasma membranesq ~ ( t C:costameresq ~ ( t C:cytoskeletonsq ~ ( t C:centrosomesq ~ ( t C:endoplasmic reticulumsq ~ k ( t C:mitochondrionsq ~ ( t
C:polysomesq ~ ( t
C:spectrinsq ~ ( t C:plasma membranepppppppppppppxsq ~ uq ~
sq ~ ( t F:protein bindingt 5515sq ~ ( t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ (t IPR000243t
Pept_T1A_subBsq ~ (t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ (t
Proteasomet PF00227pppppppppxt P20618t
PSB1_HUMANsq ~ uq ~
sq ~ (t Proteasome component C5sq ~ (t Macropain subunit C5sq ~ (t /Multicatalytic endopeptidase complex subunit C5sq ~ (t Proteasome gamma chainppppppxt Homo sapienst CRYABsq ~? U %t Alpha-crystallin B chainsq ~ uq ~
sq ~ Ut ENSG00000109846pppppppppxsq ~ uq ~
sq ~ U t CRYABsq ~ U t CRYA2ppppppppxsq ~ Huq ~
Psq ~ U t P:signal transductionsq ~ U t P:visual perceptionsq ~ U t P:anti-apoptosissq ~ U t P:cell motilitysq ~ J U t P:response to unfolded proteinsq ~ O U t
P:circulationsq ~ ! U t 0P:negative regulation of survival gene produc...sq ~ U t P:axonogenesissq ~
U t 0P:transmembrane receptor protein serine/threo...sq ~ W U t P:carbohydrate metabolic processsq ~ . U t (P:regulation of translational initiationsq ~ J U t .P:regulation of progression through cell cyclesq ~ U t P:mitochondrial transportsq ~ U t !P:cellular copper ion homeostasissq ~ U t P:striated muscle contractionsq ~ U t P:cell cycle arrestsq ~ uT U t 0P:actin cytoskeleton organization and biogenesissq ~ v U t P:myofibril assemblysq ~ vd U t $P:negative regulation of cell growthsq ~ U t P:neuromuscular processsq ~ H U t 0P:negative regulation of thymidylate synthase...sq ~ 6 U t 0P:regulation of mitochondrial membrane permea...sq ~ , U t +P:release of cytochrome c from mitochondriasq ~ U t (P:protein amino acid autophosphorylationsq ~ U t 0P:negative regulation of S phase of mitotic c...sq ~ U t P:regulation of transcriptionsq ~ u U t 0P:positive regulation of nitric oxide biosynt...sq ~ 9 U t P:protein foldingsq ~ U t "P:regulation of cell proliferationsq ~ * U t P:protein refoldingsq ~ ~ U t 0P:negative regulation of intracellular transportsq ~ ʩ U t 0P:regulation of mitochondrial membrane potentialsq ~ U t P:mitosissq ~ U t F:protein bindingsq ~ 2 U t F:identical protein bindingsq ~ U t F:transcription factor bindingsq ~ P U t (F:structural constituent of cytoskeletonsq ~ U t
F:ATP bindingsq ~ B U t *F:protein serine/threonine kinase activitysq ~ x U t F:TPR domain bindingsq ~ U t F:phosphatidylinositol bindingsq ~ v U t *F:nitric-oxide synthase regulator activitysq ~ U t F:calmodulin bindingsq ~ \ U t $F:structural constituent of eye lenssq ~ B~ U t F:myosin bindingsq ~ 3 U t #F:protein homodimerization activitysq ~ N U t F:structural molecule activitysq ~ s U t "F:structural constituent of musclesq ~ U t .F:serine-type endopeptidase inhibitor activitysq ~ U t F:citrate (Si)-synthase activitysq ~ U t F:beta-amyloid bindingsq ~ U t F:alpha-actinin bindingsq ~ i U t C:cytoplasmsq ~ U t C:integral to plasma membranesq ~ U t C:cytoskeletonsq ~ U t C:nucleussq ~ ' U t C:cell surfacesq ~ U t
C:spectrinsq ~ U t C:cytosolsq ~ U t C:extracellular regionsq ~ U t C:condensed nuclear chromosomesq ~ U t &C:proteasome complex (sensu Eukaryota)sq ~ U t C:plasma membranesq ~ U t C:mitochondrial matrixsq ~ m U t C:mitochondrial outer membranesq ~ U t C:synapsesq ~ U t C:protein complexsq ~ uB U t C:Z discsq ~ uK U t C:lamellipodiumsq ~ U t (C:NuA4 histone acetyltransferase complexsq ~ U t C:intracellularsq ~ v U t
C:growth coneppppppppxsq ~ uq ~
sq ~ U t P:anti-apoptosist 6916sq ~ U t P:muscle contractiont 6936sq ~ U t 0P:negative regulation of intracellular transportt 32387sq ~ U t P:protein foldingt 6457sq ~ U t 0P:transmembrane receptor protein tyrosine kin...t 7169sq ~ U t F:protein bindingt 5515sq ~ U t C:cytoplasmt 5737pppxsq ~ uq ~
sq ~ Ut IPR011369t Alpha-crystallinsq ~ Ut IPR001436t Alpha-crystallin/HSPsq ~ Ut IPR012273t Alpha-crystallin_Bsq ~ Ut IPR003090t Alpha-crystallin_Nsq ~ Ut IPR002068t Hsp20pppppxsq ~ uq ~
sq ~ Ut
Crystallint PF00525sq ~ Ut HSP20t PF00011ppppppppxt P02511t CRYAB_HUMANsq ~ uq ~
sq ~ Ut Alpha(B)-crystallinsq ~ Ut Rosenthal fiber componentsq ~ Ut Heat shock protein beta-5sq ~ Ut HspB5sq ~ Ut !Renal carcinoma antigen NY-REN-27pppppxt Homo sapienst SMAD1sq ~?= %t )Mothers against decapentaplegic homolog 1sq ~ uq ~
sq ~ t ENSG00000170365pppppppppxsq ~ uq ~
sq ~ t SMAD1sq ~ t BSP1sq ~ t MADH1sq ~ t MADR1ppppppxsq ~ uq ~
@sq ~ t ,P:regulation of transcription, DNA-dependentsq ~
t P:signal transductionsq ~ D t $P:protein amino acid phosphorylationsq ~ t /P:transcription from RNA polymerase II promotersq ~ t P:nervous system developmentsq ~ t 0P:regulation of transcription from RNA polyme...sq ~ @a t &P:negative regulation of transcriptionsq ~ t 0P:transforming growth factor beta receptor si...sq ~ ` t +P:small GTPase mediated signal transductionsq ~ ] t +P:negative regulation of cell proliferationsq ~ u t &P:positive regulation of transcriptionsq ~ J t .P:regulation of progression through cell cyclesq ~ x t 0P:positive regulation of transcription from R...sq ~ t !P:intracellular protein transportsq ~ t P:cell cycle arrestsq ~ w9 t %P:androgen receptor signaling pathwaysq ~ & t P:response to stresssq ~ t P:apoptosissq ~ F t (P:N-terminal peptidyl-lysine acetylationsq ~ k t &P:multicellular organismal developmentsq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ > t
P:cell growthsq ~ t P:cell adhesionsq ~ \ t +P:positive regulation of cell proliferationsq ~ : t P:protein transportsq ~ = t %P:integrin-mediated signaling pathwaysq ~ V t
P:JNK cascadesq ~ [ t P:JAK-STAT cascadesq ~ W t P:carbohydrate metabolic processsq ~ t P:cell cyclesq ~ t P:transcription, DNA-dependentsq ~ t P:anti-apoptosissq ~ z t 0P:negative regulation of transcription from R...sq ~ ` t P:homeostatic processsq ~ t (P:nuclear mRNA splicing, via spliceosomesq ~ t P:skeletal developmentsq ~ t P:response to hypoxiasq ~ E t 0P:positive regulation of transcription, DNA-d...sq ~ 9 t P:protein foldingsq ~ t P:transcription terminationsq ~ $Z t P:protein secretionsq ~ t P:induction of apoptosissq ~ t $P:central nervous system developmentsq ~ t P:ectoderm developmentsq ~ t P:brain developmentsq ~ t P:gastrulationsq ~ c t P:cell-cell signalingsq ~ d t P:synaptic transmissionsq ~ t P:axon guidancesq ~ | t P:sex differentiationsq ~ b t !P:Rho protein signal transductionsq ~ K t P:protein kinase cascadesq ~ t P:cell motilitysq ~ t "P:regulation of muscle contractionsq ~ + t P:immune responsesq ~ H t P:ER-nuclear signaling pathwaysq ~ J t P:response to unfolded proteinsq ~ Y t 0P:chromosome organization and biogenesis (sen...sq ~ b t *P:cytoskeleton organization and biogenesissq ~ t -P:mitotic spindle organization and biogenesissq ~ t P:chemotaxissq ~ t P:mitosissq ~ t 0P:negative regulation of epidermal growth fac...sq ~
t 0P:transforming growth factor beta receptor co...sq ~ t P:SMAD protein complex assemblysq ~ J t !P:intracellular signaling cascadesq ~ t 0P:epidermal growth factor receptor signaling ...sq ~ ȍ t 'P:regulation of oxidoreductase activitysq ~ t +P:early endosome to late endosome transportsq ~ : t "P:negative regulation of apoptosissq ~ # t 0P:protein ubiquitination during ubiquitin-dep...sq ~ N t 0P:long-term strengthening of neuromuscular ju...sq ~ t 0P:negative regulation of activin receptor sig...sq ~ ~ t 0P:positive regulation of proteasomal ubiquiti...sq ~ | t 0P:regulation of glucocorticoid metabolic processsq ~ z t /P:positive regulation of protein ubiquitinationsq ~ x t P:prostate gland developmentsq ~ ws t 0P:ubiquitin-dependent SMAD protein catabolic ...sq ~ 0 t 0P:intermediate filament cytoskeleton organiza...sq ~ w t P:basal protein localizationsq ~ t 0P:establishment and/or maintenance of epithel...sq ~ Ǔ t 0P:positive regulation of transcription factor...sq ~ I t !P:actin filament bundle formationsq ~ ' t #P:regulation of synaptic plasticitysq ~ t P:focal adhesion formationsq ~ t 0P:positive regulation of Ras protein signal t...sq ~ t $P:positive regulation of JNK cascadesq ~ ɔ t P:protein maturationsq ~ D t 0P:negative regulation of transcription, DNA-d...sq ~ t 0P:positive regulation of striated muscle deve...sq ~ t P:regulation of transcriptionsq ~ w2 t .P:negative regulation of BMP signaling pathwaysq ~ w0 t 0P:negative regulation of transforming growth ...sq ~ @ t P:protein ubiquitinationsq ~ ?E t P:endosome transportsq ~ ?@ t P:vesicle-mediated transportsq ~ & t P:organ morphogenesissq ~ & t !P:embryonic pattern specificationsq ~ % t $P:anatomical structure morphogenesissq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ ! t .P:release of cytoplasmic sequestered NF-kappaBsq ~ [ t P:cell proliferationsq ~ t P:protein localizationsq ~ @ t P:histone acetylationsq ~ Bw t 0P:regulation of transforming growth factor be...sq ~ C t P:regulation of exocytosissq ~ w/ t 0P:positive regulation of transforming growth ...sq ~ w- t P:BMP signaling pathwaysq ~ v t )P:ER-associated protein catabolic processsq ~ v t 'P:positive regulation of cell migrationsq ~ vF t P:regulation of ossificationsq ~ u t P:cell differentiationsq ~ u t
P:hemopoiesissq ~ Ms t P:stem cell maintenancesq ~ K t 0P:cytokine and chemokine mediated signaling p...sq ~ Jh t P:virus-host interactionsq ~ t P:phototransductionsq ~ t 0P:retrograde vesicle-mediated transport, Golg...sq ~ t P:nucleosome disassemblysq ~ t 0P:establishment and/or maintenance of chromat...sq ~ t P:nucleotide-excision repairsq ~ t P:DNA repairsq ~ s t P:DNA metabolic processsq ~ < t ,P:protein import into nucleus, translocationsq ~ r t 0P:regulation of I-kappaB kinase/NF-kappaB cas...sq ~ R t 'P:G1/S transition of mitotic cell cyclesq ~ t P:protein polyubiquitinationsq ~ t P:chromatin remodelingsq ~ t 0P:regulation of transcription from RNA polyme...sq ~ t P:transportsq ~ t P:cell fate determinationsq ~ t P:protein export from nucleussq ~ p t P:ubiquitin cyclesq ~ @ t P:protein modification processsq ~ = t P:protein complex assemblysq ~ . t (P:regulation of translational initiationsq ~ t
P:translationsq ~ t P:RNA export from nucleussq ~ t 0P:transcription initiation from RNA polymeras...sq ~ " t F:protein bindingsq ~ t
t F:transcription factor activitysq ~ t $F:transcription coactivator activitysq ~ T t F:GTPase activitysq ~ ] t
F:DNA bindingsq ~ t
F:ATP bindingsq ~ t $F:transcription corepressor activitysq ~ t F:SMAD bindingsq ~ t
F:GTP bindingsq ~ t #F:ubiquitin-protein ligase activitysq ~ b t F:chromatin bindingsq ~ B t *F:protein serine/threonine kinase activitysq ~ 2 t $F:histone acetyltransferase activitysq ~ N t F:zinc ion bindingsq ~ t F:signal transducer activitysq ~ ! t )F:phosphorylase kinase regulator activitysq ~ @ t "F:transcription activator activitysq ~ t
F:RNA bindingsq ~ t F:receptor activitysq ~ t F:androgen receptor bindingsq ~ t )F:transforming growth factor beta bindingsq ~ v t "F:thyroid hormone receptor bindingsq ~ wP t F:Hsp70 protein bindingsq ~ t F:aldehyde reductase activitysq ~ x t "F:receptor tyrosine kinase bindingsq ~ w t 0F:transforming growth factor beta receptor, i...sq ~ x t F:TPR domain bindingsq ~ w t F:protein binding, bridgingsq ~ w@ t "F:transcription regulator activitysq ~ y t F:androgen bindingsq ~ M t F:protein kinase bindingsq ~ t 0F:transforming growth factor beta receptor ac...sq ~ t F:androgen receptor activitysq ~ u t (F:Hsp70/Hsc70 protein inhibitor activitysq ~ @ t F:protein kinase activitysq ~ v t 0F:ligand-dependent nuclear receptor transcrip...sq ~ ʧ t F:Hsp90 protein bindingsq ~ c t F:MAP kinase activitysq ~ V t 0F:eukaryotic translation initiation factor 2a...sq ~ y t F:MyoD bindingsq ~ M t F:kinase bindingsq ~ y t 0F:RNA splicing factor activity, transesterifi...sq ~ z t 0F:ligand-regulated transcription factor activitysq ~ t %F:protein heterodimerization activitysq ~ z t F:ubiquitin bindingsq ~ - t F:sequence-specific DNA bindingsq ~ y t 0F:RNA polymerase II transcription factor acti...sq ~ v t 0F:RNA polymerase II transcription factor acti...sq ~ ~ t 0F:histone lysine N-methyltransferase activity...sq ~ q t F:single-stranded DNA bindingsq ~ d t F:damaged DNA bindingsq ~ t F:virion bindingsq ~ J t F:histone deacetylase bindingsq ~ 9 t F:vitamin D receptor bindingsq ~ t $F:structural constituent of ribosomesq ~ 9 t F:activin bindingsq ~ 8 t F:follistatin bindingsq ~ t 0F:RNA polymerase II transcription termination...sq ~ t +F:transcription termination factor activitysq ~ t F:SH2 domain bindingsq ~ } t F:protein N-terminus bindingsq ~ t !F:transcription cofactor activitysq ~ t F:protein dimerization activitysq ~ 3 t #F:protein homodimerization activitysq ~ t F:magnesium ion bindingsq ~ t %F:receptor signaling protein activitysq ~ t 0F:hematopoietin/interferon-class (D200-domain...sq ~ @G t 0F:RNA polymerase II transcription mediator ac...sq ~ @ t F:acetyltransferase activitysq ~ : t F:integrin bindingsq ~ P t (F:structural constituent of cytoskeletonsq ~ _ t F:transporter activitysq ~ V t F:protein C-terminus bindingsq ~ t F:tropomyosin bindingsq ~ #_ t F:electron carrier activitysq ~ t F:N-acetyltransferase activitysq ~ t F:transcription factor bindingsq ~ t F:DNA-dependent ATPase activitysq ~ t F:methyl-CpG bindingsq ~ m t F:DNA bending activitysq ~ 8 t F:ErbB-2 class receptor bindingsq ~ @ t "F:transcription repressor activitysq ~ t F:interleukin-1 receptor bindingsq ~ K t F:phosphatase regulator activitysq ~ t F:SH3/SH2 adaptor activitysq ~ 2 t F:identical protein bindingsq ~ t 0F:transforming growth factor beta receptor, c...sq ~ t ,F:guanyl-nucleotide exchange factor activitysq ~ t 0F:Rho guanyl-nucleotide exchange factor activitysq ~ t 0F:translation factor activity, nucleic acid b...sq ~ t F:GTPase activator activitysq ~ A t 0F:oxidoreductase activity, acting on NADH or ...sq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:intracellularsq ~ > t C:integral to membranesq ~ W t )C:transcription elongation factor complexsq ~ > t
C:membranesq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ w t C:mediator complexsq ~ 1 t
C:spliceosomesq ~ t C:cytosolsq ~ t C:ubiquitin ligase complexsq ~ t C:integral to plasma membranesq ~ t C:extracellular spacesq ~ t #C:histone methyltransferase complexsq ~ t C:membrane fractionsq ~ t C:spindlesq ~ t C:nuclear chromosomesq ~ t
C:Golgi stacksq ~ t C:Golgi apparatussq ~ t C:early endosomesq ~ t
C:lysosomesq ~ k t C:mitochondrionsq ~ 3 t C:activin receptor complexsq ~ t C:basement membranesq ~ t &C:cytosolic ribosome (sensu Eukaryota)sq ~ t 0C:proteasome regulatory particle (sensu Eukar...sq ~ t
C:ribosomesq ~ @ t C:nuclear bodysq ~ B t #C:transcriptional repressor complexsq ~ u t C:AP-2 adaptor complexsq ~ t C:plasma membranesq ~ uh t C:hemidesmosomesq ~ @ t C:CCAAT-binding factor complexsq ~ b t C:nucleolussq ~ 5 t C:Elongator core complexsq ~ t C:extracellular regionsq ~ } t C:cleavage furrowsq ~ t C:protein complexsq ~ z t &C:ubiquitin conjugating enzyme complexsq ~ U t C:synaptic vesiclesq ~ t C:nuclear envelopesq ~ t $C:integral to nuclear inner membranesq ~ t C:nuclear poresq ~ t
C:nucleoplasmsq ~ # t C:transcription factor complexsq ~ ' t C:cell surfacesq ~ t C:photoreceptor outer segmentsq ~ > t C:chromosomesq ~ t C:condensed nuclear chromosomesq ~ @ t ,C:DNA-directed RNA polymerase II, holoenzymesq ~ t 0C:cytosolic small ribosomal subunit (sensu Eu...sq ~ % t C:focal adhesionpppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t P:BMP signaling pathwayt 30509sq ~ t !P:embryonic pattern specificationt 9880sq ~ t 0P:transforming growth factor beta receptor si...t 7179sq ~ t F:protein bindingt 5515sq ~ t %F:receptor signaling protein activityt 5057sq ~ t "F:transcription activator activityt 16563sq ~ t C:integral to membranet 16021sq ~ t C:nucleust 5634ppxsq ~ uq ~
sq ~ t IPR013790t Dwarfinsq ~ t IPR013019t MAD_MH1sq ~ t IPR003619t MH1_Dwarfin-typesq ~ t IPR001132t MH2_Dwarfin-typeppppppxsq ~ uq ~
sq ~ t MH1t PF03165sq ~ t MH2t PF03166ppppppppxt Q15797t SMAD1_HUMANsq ~ uq ~
sq ~ t SMAD 1sq ~ t Mothers against DPP homolog 1sq ~ t Mad-related protein 1sq ~ t 3Transforming growth factor-beta-signaling protein 1sq ~ t BSP-1sq ~ t hSMAD1sq ~ t JV4-1pppxt Homo sapienst KIF3Csq ~?UUUUUO d0 %t Kinesin-like protein KIF3Csq ~ uq ~
sq ~ d0t ENSG00000084731pppppppppxsq ~ uq ~
sq ~ d0 t KIF3Cpppppppppxsq ~ uq ~
sq ~ d0 t ,P:regulation of transcription, DNA-dependentsq ~ T d0 t 'P:organelle organization and biogenesissq ~ d0 t F:protein bindingsq ~ ] d0 t
F:DNA bindingsq ~ d0 t &C:proteasome complex (sensu Eukaryota)sq ~ d0 t C:nucleusppppxsq ~ uq ~
sq ~ d0 t F:motor activityt 3774sq ~ d0 t C:kinesin complext 5871ppppppppxsq ~ uq ~
sq ~ d0t IPR001752t
kinesin_motorpppppppppxsq ~ uq ~
sq ~ d0t Kinesint PF00225pppppppppxt O14782t KIF3C_HUMANpt Homo sapienst PSB9sq ~?A)4 ) %t (Proteasome subunit beta type-9 precursorsq ~ uq ~
sq ~ )t ENSG00000204261sq ~ )t ENSG00000206232sq ~ )t ENSG00000206296pppppppxsq ~ uq ~
sq ~ ) t PSMB9sq ~ ) t LMP2sq ~ ) t RING12pppppppxsq ~ uq ~
(sq ~ w9 ) t %P:androgen receptor signaling pathwaysq ~ E ) t 0P:positive regulation of transcription, DNA-d...sq ~ w8 ) t %P:estrogen receptor signaling pathwaysq ~ / ) t P:humoral immune responsesq ~ ) t ,P:regulation of transcription, DNA-dependentsq ~ ) t F:androgen receptor bindingsq ~ ) t $F:transcription coactivator activitysq ~ } ) t F:protein N-terminus bindingsq ~ ) t F:protein bindingsq ~ ) ) t F:peptidase activitysq ~ 2 ) t $F:histone acetyltransferase activitysq ~ u ) t .F:receptor signaling complex scaffold activitysq ~ v ) t *F:nitric-oxide synthase regulator activitysq ~ vL ) t F:estrogen receptor activitysq ~ v ) t "F:thyroid hormone receptor bindingsq ~ ) t &C:proteasome complex (sensu Eukaryota)sq ~ ) t C:nucleussq ~ ) t C:protein complexsq ~ > ) t
C:membranesq ~ ) t C:cytosolsq ~ @ ) t C:chromatin remodeling complexpppppppppppppppppppxsq ~ uq ~
sq ~ ) t &C:proteasome complex (sensu Eukaryota)t 502pppppppppxsq ~ uq ~
sq ~ )t IPR000243t
Pept_T1A_subBsq ~ )t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ )t
Proteasomet PF00227pppppppppxt P28065t
PSB9_HUMANsq ~ uq ~
sq ~ )t Proteasome subunit beta-1isq ~ )t Proteasome chain 7sq ~ )t Macropain chain 7sq ~ )t ,Multicatalytic endopeptidase complex chain 7sq ~ )t RING12 proteinsq ~ )t Low molecular mass protein 2ppppxt Homo sapienst PSB8sq ~? @ %t (Proteasome subunit beta type-8 precursorsq ~ uq ~
sq ~ @t ENSG00000204264sq ~ @t ENSG00000206234sq ~ @t ENSG00000206298pppppppxsq ~ uq ~
sq ~ @ t PSMB8sq ~ @ t LMP7sq ~ @ t RING10sq ~ @ t Y2ppppppxsq ~ uq ~
sq ~ @ t P:mRNA processingsq ~ @ t P:RNA splicingsq ~ @ t F:protein bindingsq ~ y @ t 0F:RNA splicing factor activity, transesterifi...sq ~ @ t &C:proteasome complex (sensu Eukaryota)sq ~ @ t C:nucleusppppxsq ~ uq ~
sq ~ @ t F:protein bindingt 5515sq ~ @ t &C:proteasome complex (sensu Eukaryota)t 502ppppppppxsq ~ uq ~
sq ~ @t IPR000243t
Pept_T1A_subBsq ~ @t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ @t
Proteasomet PF00227pppppppppxt P28062t
PSB8_HUMANsq ~ uq ~
sq ~ @t Proteasome subunit beta-5isq ~ @t Proteasome component C13sq ~ @t Macropain subunit C13sq ~ @t 0Multicatalytic endopeptidase complex subunit C13ppppppxt Homo sapienst CSK21sq ~?*Y d %t Casein kinase II subunit alphasq ~ uq ~
sq ~ dt ENSG00000101266pppppppppxsq ~ uq ~
sq ~ d t CSNK2A1sq ~ d t CK2A1ppppppppxsq ~ uq ~
sq ~ d t P:signal transductionsq ~ d t ,P:regulation of transcription, DNA-dependentsq ~ J
d t .P:regulation of progression through cell cyclesq ~
d t 0P:regulation of transcription from RNA polyme...sq ~ d t P:anti-apoptosissq ~ [ d t P:cell proliferationsq ~ d t P:nervous system developmentsq ~ d t P:transportsq ~ = d t P:protein complex assemblysq ~ k d t &P:multicellular organismal developmentsq ~ + d t P:immune responsesq ~ O d t 0P:regulation of cyclin-dependent protein kina...sq ~ S d t P:heart developmentsq ~ d t P:cell cycle arrestsq ~ d t P:response to hypoxiasq ~ d t /P:transcription from RNA polymerase II promotersq ~ D d t $P:protein amino acid phosphorylationsq ~ \ d t +P:positive regulation of cell proliferationsq ~ ] d t +P:negative regulation of cell proliferationsq ~ d t P:DNA repairsq ~ E d t 0P:positive regulation of transcription, DNA-d...sq ~ d t P:mitosissq ~ 9 d t "P:positive regulation of apoptosissq ~ d t P:cell adhesionsq ~ d t 0P:DNA damage response, signal transduction by...sq ~ d t P:chromosome segregationsq ~ F d t &P:protein amino acid dephosphorylationsq ~ % d t $P:anatomical structure morphogenesissq ~ * d t P:inflammatory responsesq ~ @a d t &P:negative regulation of transcriptionsq ~ @ d t P:chromatin modificationsq ~ { d t !P:regulation of protein stabilitysq ~ ? d t P:phosphorylationsq ~ d t P:blood coagulationsq ~ vd d t $P:negative regulation of cell growthsq ~ d t $P:central nervous system developmentsq ~ d d t P:synaptic transmissionsq ~ d t P:RNA splicingsq ~ ! d t P:apoptotic programsq ~ s d t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ w9 d t %P:androgen receptor signaling pathwaysq ~ @ d t %P:negative regulation of angiogenesissq ~ U d t 'P:cytoplasmic sequestering of NF-kappaBsq ~ t d t P:DNA replicationsq ~ z d t P:DNA ligationsq ~ d t 0P:Wnt receptor signaling pathway through beta...sq ~ ! d t 0P:DNA damage response, signal transduction re...sq ~ d t P:base-excision repairsq ~ ` d t +P:small GTPase mediated signal transductionsq ~ ` d t P:homeostatic processsq ~ d t 0P:establishment and/or maintenance of chromat...sq ~ ɗ d t P:defense response to virussq ~ J d t P:response to unfolded proteinsq ~ 9 d t P:protein foldingsq ~ d t %P:phosphoinositide-mediated signalingsq ~ , d t +P:release of cytochrome c from mitochondriasq ~ E d t 0P:negative regulation of protein kinase activitysq ~ > d t !P:response to DNA damage stimulussq ~ d t P:lipid metabolic processsq ~ d t (P:nuclear mRNA splicing, via spliceosomesq ~ 8 d t P:cellular defense responsesq ~ z d t 0P:negative regulation of transcription from R...sq ~ u d t &P:positive regulation of transcriptionsq ~ d t 0P:transcription initiation from RNA polymeras...sq ~ d t P:nucleosome assemblysq ~ d t P:nucleosome disassemblysq ~ d t P:protein localizationsq ~ d t P:visual perceptionsq ~ d t P:sensory perceptionsq ~ d t P:hemostasissq ~ / d t P:humoral immune responsesq ~ d t P:meiotic recombinationsq ~ d t P:regulation of mitosissq ~ d t P:excretionsq ~ d t P:homophilic cell adhesionsq ~ D d t P:redox signal responsesq ~ | d t P:sex differentiationsq ~ d t P:metabolic processsq ~ d t .P:actin polymerization and/or depolymerizationsq ~ ! d t 0P:induction of apoptosis via death domain rec...sq ~ d t P:cell motilitysq ~ !` d t P:epidermis developmentsq ~ !_ d t 0P:fibroblast growth factor receptor signaling...sq ~ d t P:chemotaxissq ~ d t P:endosome to lysosome transportsq ~ ^ d t $P:insulin receptor signaling pathwaysq ~ e d t P:cell recognitionsq ~ d t P:striated muscle contractionsq ~ ( d t P:defense responsesq ~ d t P:cholesterol metabolic processsq ~ d t P:response to nutrientsq ~ d t P:cell agingsq ~ a d t !P:Ras protein signal transductionsq ~ H d t P:ER-nuclear signaling pathwaysq ~ r d t 0P:negative regulation of microtubule depolyme...sq ~ V d t
P:JNK cascadesq ~ Y d t 0P:chromosome organization and biogenesis (sen...sq ~ J d t !P:intracellular signaling cascadesq ~ 4 d t P:Notch receptor processingsq ~ . d t +P:gamma-aminobutyric acid signaling pathwaysq ~ b d t *P:cytoskeleton organization and biogenesissq ~ k d t P:microtubule depolymerizationsq ~ % d t P:protein kinase C activationsq ~ c d t P:cell-cell signalingsq ~ d t 0P:transmembrane receptor protein tyrosine kin...sq ~ G d t P:ER overload responsesq ~ A d t 0P:DNA damage response, signal transduction by...sq ~ _ d t P:striated muscle developmentsq ~ ] d t P:muscle developmentsq ~ B d t 0P:DNA damage response, signal transduction by...sq ~ C d t P:response to oxidative stresssq ~ d t P:cell-matrix adhesionsq ~ d t -P:mitotic spindle organization and biogenesissq ~ v d t P:spermatid developmentsq ~ s d t P:spermatogenesissq ~ d t %P:spindle organization and biogenesissq ~ l d t P:gamete generationsq ~ d t 0P:G-protein coupled receptor protein signalin...sq ~ ! d t 0P:induction of apoptosis by intracellular sig...sq ~ d t P:cholesterol homeostasissq ~ d t 0P:negative regulation of fatty acid biosynthe...sq ~ d t 0P:negative regulation of cyclin-dependent pro...sq ~ d t #P:positive regulation of DNA repairsq ~ d t 0P:positive regulation of global transcription...sq ~ $ d t 0P:positive regulation of protein kinase activitysq ~ . d t 0P:positive regulation of retroviral genome re...sq ~ D d t 0P:negative regulation of transcription, DNA-d...sq ~ x d t 0P:positive regulation of transcription from R...sq ~ | d t 0P:positive regulation of translational initia...sq ~ _ d t 0P:positive regulation of myoblast differentia...sq ~ u d t 0P:positive regulation of nitric oxide biosynt...sq ~ d t #P:protein import into mitochondrionsq ~ % d t 0P:mRNA transcription from RNA polymerase II p...sq ~ d t -P:amyloid precursor protein catabolic processsq ~ M d t (P:positive regulation of enzyme activitysq ~ d t )P:negative regulation of caspase activitysq ~ d t 0P:proteasomal ubiquitin-dependent protein cat...sq ~ d t $P:negative regulation of DNA bindingsq ~ d t &P:response to peptide hormone stimulussq ~ k d t P:response to estrogen stimulussq ~ d t 0P:regulation of phosphoprotein phosphatase ac...sq ~ d t .P:negative regulation of centriole replicationsq ~ d t &P:inositol phosphate dephosphorylationsq ~ d t P:sequestering of calcium ionsq ~ d t 0P:release of sequestered calcium ion into cyt...sq ~ > d t P:protein tetramerizationsq ~ d t P:neuron apoptosissq ~ ɀ d t P:regulation of dopamine uptakesq ~ d t P:cellular response to stimulussq ~ d t P:regulation of cell cyclesq ~ ʷ d t 0P:negative regulation of focal adhesion forma...sq ~ ʺ d t 0P:negative regulation of protein kinase B sig...sq ~ ǝ d t P:regulation of DNA bindingsq ~ Ǚ d t *P:negative regulation of helicase activitysq ~ ǔ d t .P:activation of NF-kappaB transcription factorsq ~ d t $P:phosphoinositide dephosphorylationsq ~ 6 d t 0P:regulation of mitochondrial membrane permea...sq ~ d t 0P:insulin-like growth factor receptor signali...sq ~ d t P:RNA transportsq ~ Q d t %P:positive regulation of neurogenesissq ~ l d t !P:regulation of insulin secretionsq ~ Ƥ d t #P:T cell receptor signaling pathwaysq ~ ƥ d t #P:B cell receptor signaling pathwaysq ~ Ʃ d t 0P:positive regulation of antigen receptor-med...sq ~ d t 0P:regulation of attachment of spindle microtu...sq ~ 8 d t
P:myelinationsq ~ ! d t ,P:induction of apoptosis by oxidative stresssq ~ 0 d t P:programmed cell deathsq ~ 6 d t P:astrocyte developmentsq ~ 6 d t P:oligodendrocyte developmentsq ~ : d t P:protein transportsq ~ = d t P:monoamine transportsq ~ @e d t P:protein processingsq ~ @ d t P:histone acetylationsq ~ F d t (P:N-terminal peptidyl-lysine acetylationsq ~ K d t 0P:cytokine and chemokine mediated signaling p...sq ~ ' d t P:response to UV-Bsq ~ '1 d t P:response to organic substancesq ~ & d t ,P:negative regulation of signal transductionsq ~ ! d t %P:caspase activation via cytochrome csq ~ $W d t P:rRNA transcriptionsq ~ $X d t P:tRNA transcriptionsq ~ $ d t P:response to heatsq ~ % d t P:response to woundingsq ~ % d t P:response to virussq ~ % d t P:response to hormone stimulussq ~ & d t P:response to glucose stimulussq ~ & d t P:organ morphogenesissq ~ W d t (P:protein maturation via protein foldingsq ~ u d t .P:regulation of Wnt receptor signaling pathwaysq ~ d t 0P:positive regulation of protein amino acid d...sq ~ d t 0P:negative regulation of protein amino acid d...sq ~ * d t P:protein refoldingsq ~ t d t P:B cell proliferationsq ~ v d t -P:positive regulation of T cell proliferationsq ~ d t "P:regulation of cell proliferationsq ~ d t )P:cellular response to glucose starvationsq ~ d t )P:regulation of protein catabolic processsq ~ d t P:response to drugsq ~ d t ,P:negative regulation of histone acetylationsq ~ z d t /P:positive regulation of protein ubiquitinationsq ~ zf d t 0P:positive regulation of protein complex asse...sq ~ v d t P:T cell differentiationsq ~ v
d t P:erythrocyte differentiationsq ~ v d t P:monocyte differentiationsq ~ v7 d t #P:apoptotic chromosome condensationsq ~ v] d t P:cholesterol transportsq ~ v d t 'P:negative regulation of cell migrationsq ~ w& d t ,P:negative regulation of bone mineralizationsq ~ w' d t &P:regulation of cell redox homeostasissq ~ y d t P:neurite developmentsq ~ # d t 0P:positive regulation of tyrosine phosphoryla...sq ~ d t 0P:negative regulation of cytokine and chemoki...sq ~ d t 0P:generation of precursor metabolites and energysq ~ E d t )P:pyrimidine nucleoside metabolic processsq ~ | d t "P:DNA unwinding during replicationsq ~ ~ d t P:DNA replication initiationsq ~ d t P:nucleotide-excision repairsq ~ d t P:postreplication repairsq ~ d t 0P:double-strand break repair via nonhomologou...sq ~ d t P:DNA methylationsq ~ d t P:DNA recombinationsq ~ d t P:loss of chromatin silencingsq ~ W d t P:carbohydrate metabolic processsq ~ M d t P:DNA damage checkpointsq ~ R d t 'P:G1/S transition of mitotic cell cyclesq ~ { d t 0P:negative regulation of T cell mediated cyto...sq ~ - d t &P:epithelial to mesenchymal transitionsq ~ d t P:neural crest cell migrationsq ~ d t P:ovarian follicle developmentsq ~ d t P:angiogenesissq ~ d t P:skeletal developmentsq ~ d t 0P:double-strand break repair via homologous r...sq ~ d t P:activation of MAPK activitysq ~ d t .P:establishment of mitotic spindle orientationsq ~ d t )P:negative regulation of neuron apoptosissq ~ d t P:transcriptionsq ~ d t P:apoptosissq ~ l d t
P:proteolysissq ~ m d t )P:membrane protein ectodomain proteolysissq ~ p d t P:ubiquitin cyclesq ~ d t P:protein targetingsq ~ d t P:mitochondrial transportsq ~ d t P:induction of apoptosissq ~ d t !P:cellular copper ion homeostasissq ~ d t P:cellular iron ion homeostasissq ~ d t !P:intracellular protein transportsq ~ d t 0P:retrograde vesicle-mediated transport, Golg...sq ~ d t P:nucleocytoplasmic transportsq ~ ] d t +P:protein amino acid O-linked glycosylationsq ~ d t 0P:transcription termination from RNA polymera...sq ~ d t P:transcription, DNA-dependentsq ~ d t 0P:regulation of transcription from RNA polyme...sq ~ d t 0P:regulation of transcription from RNA polyme...sq ~ d t P:rRNA processingsq ~ d t 0P:RNA elongation from RNA polymerase II promotersq ~ d t 0P:transcription initiation from RNA polymeras...sq ~ d t P:RNA catabolic processsq ~ d t
P:translationsq ~ @ d t P:protein modification processsq ~ . d t (P:regulation of translational initiationsq ~ d t P:translational elongationsq ~ L d t F:protein bindingsq ~ t d t F:transcription factor activitysq ~ d t $F:transcription coactivator activitysq ~ d t
F:RNA bindingsq ~ ] d t
F:DNA bindingsq ~ v d t 0F:RNA polymerase II transcription factor acti...sq ~ d t F:signal transducer activitysq ~ 2 d t F:identical protein bindingsq ~ M d t F:enzyme bindingsq ~ 3 d t #F:protein homodimerization activitysq ~ d t F:transcription factor bindingsq ~ M d t F:protein kinase bindingsq ~ N d t F:zinc ion bindingsq ~ d t %F:protein heterodimerization activitysq ~ } d t F:protein N-terminus bindingsq ~ V d t F:protein C-terminus bindingsq ~ d t
F:ATP bindingsq ~ d t (F:translation initiation factor activitysq ~ 7 d t F:histone deacetylase activitysq ~ y d t 0F:RNA polymerase II transcription factor acti...sq ~ u d t 'F:protein tyrosine phosphatase activitysq ~ ! d t 'F:protein kinase CK2 regulator activitysq ~ NJ d t F:unfolded protein bindingsq ~ s d t F:NF-kappaB bindingsq ~ d t F:copper ion bindingsq ~ B d t *F:protein serine/threonine kinase activitysq ~ _ d t F:transporter activitysq ~ d t 0F:type 1 serine/threonine specific protein ph...sq ~ @ d t "F:transcription activator activitysq ~ N d t F:structural molecule activitysq ~ J d t F:protein kinase CK2 activitysq ~ ! d t 0F:protein phosphatase type 2A regulator activitysq ~ d t F:FK506 bindingsq ~ T d t F:GTPase activitysq ~ = d t F:tubulin bindingsq ~ @ d t F:protein kinase activitysq ~ U d t *F:cyclin-dependent protein kinase activitysq ~ @ d t "F:transcription repressor activitysq ~ d t $F:transcription corepressor activitysq ~ b d t F:chromatin bindingsq ~ ` d t F:AT DNA bindingsq ~ d t F:growth factor activitysq ~ d t F:metal ion bindingsq ~ Q d t F:microtubule bindingsq ~ d t F:androgen receptor bindingsq ~ d t F:GABA-A receptor activitysq ~ d t #F:protein kinase inhibitor activitysq ~ d t (F:protein phosphatase inhibitor activitysq ~ d t #F:ubiquitin-protein ligase activitysq ~ d t 0F:protein tyrosine phosphatase activator acti...sq ~ x d t F:TPR domain bindingsq ~ d t F:nuclease activitysq ~ v d t 0F:ligand-dependent nuclear receptor transcrip...sq ~ = d t F:phosphate bindingsq ~ i d t "F:protein-tyrosine kinase activitysq ~ r d t /F:protein serine/threonine phosphatase activitysq ~ d t F:histone bindingsq ~ d t 0F:cyclin-dependent protein kinase inhibitor a...sq ~ y` d t F:heat shock protein bindingsq ~ V d t -F:phosphatidylinositol-3-phosphatase activitysq ~ w d t F:caspase activitysq ~ d t F:SH2 domain bindingsq ~ d t #F:uracil DNA N-glycosylase activitysq ~ d t #F:histone acetyltransferase bindingsq ~ d t F:enzyme inhibitor activitysq ~ d t F:phosphodiesterase I activitysq ~ d t F:ribonuclease H activitysq ~ d t F:endodeoxyribonuclease activitysq ~ w d t F:protein binding, bridgingsq ~ j d t 0F:transmembrane receptor protein tyrosine kin...sq ~ { d t "F:ubiquitin protein ligase bindingsq ~ q d t %F:phosphoprotein phosphatase activitysq ~ 2 d t $F:histone acetyltransferase activitysq ~ d t F:dynein bindingsq ~ d t !F:transcription cofactor activitysq ~ } d t 0F:RNA polymerase III transcription factor act...sq ~ { d t #F:steroid hormone receptor activitysq ~ u d t F:retinoid X receptor bindingsq ~ x d t 0F:specific RNA polymerase II transcription fa...sq ~ u d t 0F:RNA polymerase I transcription factor activitysq ~ q d t F:single-stranded DNA bindingsq ~ j d t F:double-stranded DNA bindingsq ~ d t F:virion bindingsq ~ > d t *F:low-density lipoprotein receptor bindingsq ~ d t F:DNA strand annealing activitysq ~ y d t F:MyoD bindingsq ~ d t 0F:inositol-1,3,4,5-tetrakisphosphate 3-phosph...sq ~ d t F:protein phosphatase 2A bindingsq ~ X d t 0F:phosphatidylinositol-3,4-bisphosphate 3-pho...sq ~ d t $F:structural constituent of ribosomesq ~ d t (F:translation elongation factor activitysq ~ - d t F:sequence-specific DNA bindingsq ~ ( d t 'F:heme oxygenase (decyclizing) activitysq ~ 1 d t &F:diamine N-acetyltransferase activitysq ~ d t !F:acetyl-CoA carboxylase activitysq ~ J d t F:histone deacetylase bindingsq ~ d t 0F:peroxisome proliferator activated receptor ...sq ~ N d t .F:DNA topoisomerase (ATP-hydrolyzing) activitysq ~ ' d t 'F:single-stranded telomeric DNA bindingsq ~ M d t #F:DNA topoisomerase type I activitysq ~ E d t F:DNA ligase activitysq ~ B d t 0F:DNA-(apurinic or apyrimidinic site) lyase a...sq ~ z d t F:ubiquitin bindingsq ~ ; d t &F:DNA-directed RNA polymerase activitysq ~ d t #F:complement component C1r activitysq ~ d t F:actin bindingsq ~ d t F:motor activitysq ~ d t #F:phosphoinositide 3-kinase bindingsq ~ u d t (F:Hsp70/Hsc70 protein inhibitor activitysq ~ v d t *F:nitric-oxide synthase regulator activitysq ~ M d t F:beta-catenin bindingsq ~ #0 d t F:DNA-methyltransferase activitysq ~ #_ d t F:electron carrier activitysq ~ d t F:sugar bindingsq ~ d t $F:insulin-like growth factor bindingsq ~ d t F:calcium ion bindingsq ~ d t F:water transporter activitysq ~ d t F:sodium channel activitysq ~ P d t (F:structural constituent of cytoskeletonsq ~ : d t F:integrin bindingsq ~ ; d t F:sterol transporter activitysq ~ <} d t F:cholesterol bindingsq ~ ## d t F:ribonuclease E activitysq ~ != d t *F:anion transmembrane transporter activitysq ~ o d t F:enzyme activator activitysq ~ d t F:DNA-dependent ATPase activitysq ~ d t 0F:translation factor activity, nucleic acid b...sq ~ d t 'F:nuclear localization sequence bindingsq ~ d t /F:cAMP response element binding protein bindingsq ~ d t F:drug bindingsq ~ d t (F:acetylglucosaminyltransferase activitysq ~ d t F:3'-5' exonuclease activitysq ~ d t %F:protein kinase C inhibitor activitysq ~ d t F:vitamin D3 receptor activitysq ~ !8 d t .F:monoamine transmembrane transporter activitysq ~ ' d t -F:insulin-like growth factor receptor bindingsq ~ ?{ d t 0F:general RNA polymerase II transcription fac...sq ~ @k d t F:oxidoreductase activitysq ~ d t !F:transmembrane receptor activitysq ~ u d t F:PDZ domain bindingsq ~ d t 0F:transmembrane receptor protein tyrosine pho...sq ~ d t !F:small GTPase regulator activitysq ~ d t F:protein kinase C bindingsq ~ d t .F:serine-type endopeptidase inhibitor activitysq ~ d t 0F:aryl hydrocarbon receptor nuclear transloca...sq ~ d t 0F:transmembrane receptor protein tyrosine kin...sq ~ d t ,F:guanyl-nucleotide exchange factor activitysq ~ d t F:receptor activitysq ~ ? d t 0F:phosphatidylinositol-3,4,5-trisphosphate 3-...sq ~ d t F:Ran GTPase activator activitysq ~ d t F:death receptor bindingsq ~ & d t F:insulin receptor bindingsq ~ $ d t C:nucleussq ~ i d t C:cytoplasmsq ~ d t C:integral to plasma membranesq ~ b d t C:nucleolussq ~ d t C:cytosolsq ~ d t C:membrane fractionsq ~ d t C:endoplasmic reticulumsq ~ # d t C:transcription factor complexsq ~ d t C:plasma membranesq ~ W d t !C:perinuclear region of cytoplasmsq ~ d t
C:nucleoplasmsq ~ d t C:extracellular regionsq ~ d t C:intracellularsq ~ d t C:soluble fractionsq ~ d t C:Golgi apparatussq ~ d t C:extracellular spacesq ~ v d t C:histone deacetylase complexsq ~ k d t C:mitochondrionsq ~ d t
C:kinetochoresq ~ ? d t C:nuclear matrixsq ~ d t C:Golgi membranesq ~ 1 d t
C:spliceosomesq ~ d t &C:proteasome complex (sensu Eukaryota)sq ~ d t 0C:eukaryotic translation elongation factor 1 ...sq ~ d t C:microsomesq ~ > d t C:integral to membranesq ~ A d t C:lipid raftsq ~ ? d t C:lateral plasma membranesq ~ d t C:insoluble fractionsq ~ x d t "C:beta-catenin destruction complexsq ~ 2 d t
C:cell cortexsq ~ d t
C:endosomesq ~ d t 0C:eukaryotic translation initiation factor 2B...sq ~ d t 0C:eukaryotic translation initiation factor 2 ...sq ~ d t C:chromatinsq ~ d t C:condensed nuclear chromosomesq ~ d t 0C:cytosolic large ribosomal subunit (sensu Eu...sq ~ D d t C:protein kinase CK2 complexsq ~ d t C:cytoskeletonsq ~ % d t C:focal adhesionsq ~ d t C:intercellular junctionsq ~ ~ d t %C:transcription factor TFIIIB complexsq ~ = d t C:microtubule cytoskeletonsq ~ d t C:intermediate filamentsq ~ d t %C:protein phosphatase type 2A complexsq ~ d t C:spindle microtubulesq ~ d t C:microtubule associated complexsq ~ d t C:nuclear chromosomesq ~ d t C:astral microtubulesq ~ d t
C:ribosomesq ~ =
d t C:actin cytoskeletonsq ~ d t C:spindlesq ~ R d t C:gamma-tubulin ring complexsq ~ @ d t C:caveolar membranesq ~ . d t C:chromatin assembly complexsq ~ ! d t .C:DNA-directed RNA polymerase II, core complexsq ~ M d t C:extrinsic to membranesq ~ > d t $C:cytoplasmic membrane-bound vesiclesq ~ wB d t 0C:heterogeneous nuclear ribonucleoprotein com...sq ~ @ d t
C:PML bodysq ~ d t C:nuclear poresq ~ d t $C:integral to nuclear inner membranesq ~ d t $C:proteinaceous extracellular matrixsq ~ $r d t -C:DNA topoisomerase complex (ATP-hydrolyzing)sq ~ w d t C:midbodysq ~ d t C:centrosomesq ~ d t C:endoplasmic reticulum membranesq ~ d t C:endoplasmic reticulum lumensq ~ d t C:mitochondrial matrixsq ~ W d t )C:transcription elongation factor complexsq ~ z d t C:BRCA1-BARD1 complexsq ~ d t
C:spectrinsq ~ z! d t 'C:CD95 death-inducing signaling complexsq ~ d t
C:lysosomesq ~ u d t C:clathrin coatsq ~ d t C:nuclear envelopeppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ d t $P:protein amino acid phosphorylationt 6468sq ~ d t P:signal transductiont 7165sq ~ d t F:protein kinase CK2 activityt 4682sq ~ d t F:protein N-terminus bindingt 47485sq ~ d t C:nucleust 5634sq ~ d t C:plasma membranet 5886ppppxsq ~ uq ~
sq ~ dt IPR000719t Prot_kinase_coresq ~ dt IPR008271t Ser_thr_pkin_ASsq ~ dt IPR002290t Ser_thr_pkinasepppppppxsq ~ uq ~
sq ~ dt Pkinaset PF00069pppppppppxt P68400t CSK21_HUMANsq ~ uq ~
sq ~ dt CK IIpppppppppxt Homo sapienst PSB7sq ~?Վ0X # %t (Proteasome subunit beta type-7 precursorsq ~ uq ~
sq ~ #t ENSG00000136930pppppppppxsq ~ uq ~
sq ~ # t PSMB7pppppppppxsq ~ $uq ~
(sq ~ o # t /P:ubiquitin-dependent protein catabolic processsq ~ J # t .P:regulation of progression through cell cyclesq ~ . # t (P:regulation of translational initiationsq ~ E # t 0P:negative regulation of protein kinase activitysq ~ n # t P:ATP-dependent proteolysissq ~ # t P:mitosissq ~ # t P:signal transductionsq ~ O # t
P:circulationsq ~ [ # t P:cell proliferationsq ~ uT # t 0P:actin cytoskeleton organization and biogenesissq ~ # t P:proteasome assemblysq ~ # t 0P:RNA elongation from RNA polymerase II promotersq ~ # t (P:protein amino acid autophosphorylationsq ~
# t F:protein bindingsq ~ O # t F:endopeptidase activitysq ~ B # t *F:protein serine/threonine kinase activitysq ~ ) # t F:peptidase activitysq ~ A # t F:ATPase activitysq ~ # t
F:RNA bindingsq ~ P # t (F:structural constituent of cytoskeletonsq ~ w3 # t F:snoRNA bindingsq ~ # t F:phosphatidylinositol bindingsq ~ 2 # t F:identical protein bindingsq ~ !Z # t F:proteasome activator activitysq ~ # t &C:proteasome complex (sensu Eukaryota)sq ~ # t C:nucleussq ~ # t +C:proteasome core complex (sensu Eukaryota)sq ~ # t C:protein complexsq ~ # t C:cytosolsq ~ # t C:integral to plasma membranesq ~ # t
C:spectrinsq ~ # t C:plasma membranesq ~ # t C:membrane fractionsq ~ d # t +C:small nucleolar ribonucleoprotein complexsq ~ i # t C:cytoplasmsq ~ # t C:centrosomeppppxsq ~ uq ~
sq ~ # t &C:proteasome complex (sensu Eukaryota)t 502pppppppppxsq ~ uq ~
sq ~ #t IPR000243t
Pept_T1A_subBsq ~ #t IPR001353t Proteasome_A_Bppppppppxsq ~ uq ~
sq ~ #t
Proteasomet PF00227pppppppppxt Q99436t
PSB7_HUMANsq ~ uq ~
sq ~ #t Proteasome subunit Zsq ~ #t Macropain chain Zsq ~ #t ,Multicatalytic endopeptidase complex chain Zpppppppxt Homo sapienst CDN1Asq ~?ְ G > H %t #Cyclin-dependent kinase inhibitor 1sq ~ uq ~
sq ~ >t ENSG00000124762pppppppppxsq ~ uq ~
sq ~ > t CDKN1Asq ~ > t CAP20sq ~ > t CDKN1sq ~ > t CIP1sq ~ > t MDA6sq ~ > t PIC1sq ~ > t SDI1sq ~ > t WAF1ppxsq ~ uq ~
@sq ~ J > t .P:regulation of progression through cell cyclesq ~ [ > t P:cell proliferationsq ~ O > t 0P:regulation of cyclin-dependent protein kina...sq ~ R > t 'P:G1/S transition of mitotic cell cyclesq ~ D > t $P:protein amino acid phosphorylationsq ~ > t P:DNA repairsq ~ t > t P:DNA replicationsq ~ > t P:cell cycle arrestsq ~ ] > t +P:negative regulation of cell proliferationsq ~ E > t 0P:positive regulation of transcription, DNA-d...sq ~ > t P:signal transductionsq ~ > t ,P:regulation of transcription, DNA-dependentsq ~ : > t "P:negative regulation of apoptosissq ~ > t 0P:traversing start control point of mitotic c...sq ~ w9 > t %P:androgen receptor signaling pathwaysq ~ vd > t $P:negative regulation of cell growthsq ~ K > t 0P:cytokine and chemokine mediated signaling p...sq ~ k > t &P:multicellular organismal developmentsq ~ > t P:cell motilitysq ~ \ > t +P:positive regulation of cell proliferationsq ~ > t P:induction of apoptosissq ~ > t P:anti-apoptosissq ~ > t P:regulation of DNA replicationsq ~ > t P:apoptosissq ~ > t /P:transcription from RNA polymerase II promotersq ~ & > t P:response to stresssq ~ u > t &P:positive regulation of transcriptionsq ~ V > t 'P:G2/M transition of mitotic cell cyclesq ~ > t P:activation of MAPKKK activitysq ~ L > t P:DNA replication checkpointsq ~ K > t P:cell cycle checkpointsq ~ z > t 0P:negative regulation of transcription from R...sq ~ > > t P:protein tetramerizationsq ~ = > t P:protein complex assemblysq ~ v > t
P:G1 phasesq ~ E > t 0P:negative regulation of protein kinase activitysq ~ G > t %P:protein amino acid ADP-ribosylationsq ~ > t 0P:generation of precursor metabolites and energysq ~ > t P:nucleosome assemblysq ~ > t 0P:nucleobase, nucleoside, nucleotide and nucl...sq ~ ' > t #P:regulation of synaptic plasticitysq ~ z > t P:DNA ligationsq ~ > t P:M phasesq ~ > t P:nucleosome disassemblysq ~ > t P:base-excision repairsq ~ Ǚ > t *P:negative regulation of helicase activitysq ~ > t 0P:double-strand break repair via nonhomologou...sq ~ l > t
P:proteolysissq ~ p > t P:ubiquitin cyclesq ~ > t #P:nitric oxide biosynthetic processsq ~ K > t P:protein kinase cascadesq ~ J > t !P:intracellular signaling cascadesq ~ > t 0P:G-protein coupled receptor protein signalin...sq ~ > t P:male meiosis Isq ~ > t P:meiotic recombinationsq ~ > t 0P:mitotic cell cycle G2/M transition DNA dama...sq ~ [ > t P:JAK-STAT cascadesq ~ > t P:cell cyclesq ~ G > t P:ER overload responsesq ~ > > t !P:response to DNA damage stimulussq ~ < > t ,P:protein import into nucleus, translocationsq ~ > t P:activated T cell apoptosissq ~ M > t P:DNA damage checkpointsq ~ P > t P:G1 phase of mitotic cell cyclesq ~ > t P:nucleocytoplasmic transportsq ~ > t P:transportsq ~ Z > t P:JUN phosphorylationsq ~ $ > t P:response to heatsq ~ D > t 0P:negative regulation of transcription, DNA-d...sq ~ > t ,P:negative regulation of histone acetylationsq ~ > t +P:regulation of progression through S phasesq ~ y > t P:neurite developmentsq ~ v > t )P:ER-associated protein catabolic processsq ~ > t (P:protein amino acid autophosphorylationsq ~ v8 > t (P:nuclear fragmentation during apoptosissq ~ v > t P:keratinocyte differentiationsq ~ u > t P:myeloid cell differentiationsq ~ N > t 0P:long-term strengthening of neuromuscular ju...sq ~ > t )P:cellular response to glucose starvationsq ~ > t 0P:negative regulation of progression through ...sq ~ > t %P:regulation of lipid kinase activitysq ~ > t )P:positive regulation of neuron apoptosissq ~ > t P:nucleotide-excision repairsq ~ # > t 0P:protein ubiquitination during ubiquitin-dep...sq ~ > t 0P:DNA damage response, signal transduction by...sq ~ ` > t P:homeostatic processsq ~ U > t P:regulation of phosphorylationsq ~ > t P:response to hypoxiasq ~ F > t !P:peptidyl-serine phosphorylationsq ~ F > t (P:N-terminal peptidyl-lysine acetylationsq ~ > t 0P:insulin-like growth factor receptor signali...sq ~ > t %P:phosphoinositide-mediated signalingsq ~ > t (P:negative regulation of DNA replicationsq ~ > t P:protein localizationsq ~ > t P:cell agingsq ~ > t P:axon guidancesq ~ > t P:nervous system developmentsq ~ s > t P:spermatogenesissq ~ 6 > t 0P:regulation of mitochondrial membrane permea...sq ~ ^ > t $P:insulin receptor signaling pathwaysq ~ @ > t P:histone deacetylationsq ~ @ > t P:histone acetylationsq ~ @ > t P:protein ubiquitinationsq ~ ?@ > t P:vesicle-mediated transportsq ~ &> > t P:embryonic developmentsq ~ $ > t P:response to UVsq ~ > t P:regulation of cell growthsq ~ ! > t %P:caspase activation via cytochrome csq ~ l > t P:gamete generationsq ~ $ > t F:protein bindingsq ~ U > t *F:cyclin-dependent protein kinase activitysq ~ > t
F:ATP bindingsq ~ ] > t
F:DNA bindingsq ~ t > t F:transcription factor activitysq ~ 2 > t F:identical protein bindingsq ~ B > t *F:protein serine/threonine kinase activitysq ~ > t $F:transcription coactivator activitysq ~ > t F:transcription factor bindingsq ~ @ > t F:protein kinase activitysq ~ > t $F:transcription corepressor activitysq ~ N > t F:zinc ion bindingsq ~ > t F:androgen receptor bindingsq ~ J > t F:protein kinase CK2 activitysq ~ } > t F:protein N-terminus bindingsq ~ > t #F:ubiquitin-protein ligase activitysq ~ > t (F:protein phosphatase inhibitor activitysq ~ v > t -F:DNA polymerase processivity factor activitysq ~ a > t F:JUN kinase activitysq ~ ~ > t F:MutLalpha complex bindingsq ~ > t F:thymidine kinase activitysq ~ > t 0F:cyclin-dependent protein kinase inhibitor a...sq ~ w > t F:caspase activitysq ~ wU > t +F:acetylcholine receptor activator activitysq ~ w@ > t "F:transcription regulator activitysq ~ > t F:receptor bindingsq ~ > t F:histone bindingsq ~ y > t F:MyoD bindingsq ~ > t F:nucleotide bindingsq ~ đ > t F:tau-protein kinase activitysq ~ > t F:DNA strand annealing activitysq ~ j > t F:double-stranded DNA bindingsq ~ T > t F:GTPase activitysq ~ n > t &F:NAD+ ADP-ribosyltransferase activitysq ~ u > t F:ErbB-3 class receptor bindingsq ~ > t %F:ATP-dependent DNA helicase activitysq ~ 2 > t $F:histone acetyltransferase activitysq ~ 7 > t F:histone deacetylase activitysq ~ > t F:nuclease activitysq ~ > t F:signal transducer activitysq ~ > t 0F:hematopoietin/interferon-class (D200-domain...sq ~ < > t )F:oxoglutarate:malate antiporter activitysq ~ ? > t F:kinase activitysq ~ y > t 0F:RNA polymerase II transcription factor acti...sq ~ > t %F:protein heterodimerization activitysq ~ > t F:copper ion bindingsq ~ 8 > t F:ErbB-2 class receptor bindingsq ~ ! > t 'F:protein kinase CK2 regulator activitysq ~ M > t F:enzyme bindingsq ~ u > t F:manganese ion bindingsq ~ > t 0F:transforming growth factor beta receptor, c...sq ~ M > t F:kinase bindingsq ~ ! > t 0F:protein phosphatase type 2A regulator activitysq ~ > t C:nucleussq ~ i > t C:cytoplasmsq ~ > t C:plasma membranesq ~ > t C:chromatinsq ~ = > t C:microtubule cytoskeletonsq ~ b > t C:nucleolussq ~ o > t C:mitochondrial inner membranesq ~ k > t C:mitochondrionsq ~ > t C:condensed nuclear chromosomesq ~ > t C:endoplasmic reticulumsq ~ D > t C:protein kinase CK2 complexsq ~ v > t C:histone deacetylase complexsq ~ > t C:ubiquitin ligase complexsq ~ > t C:integral to plasma membranesq ~ > t C:spindle microtubulesq ~ W > t !C:perinuclear region of cytoplasmsq ~ > t &C:proteasome complex (sensu Eukaryota)sq ~ > t C:cytosolsq ~ # > t C:transcription factor complexsq ~ j > t C:PCNA complexsq ~ v > t
C:dendritesq ~ w > t C:midbodysq ~ @ > t
C:PML bodysq ~ > t C:intracellularsq ~ {j > t C:neuromuscular junctionsq ~ ? > t C:nuclear matrixsq ~ v > t
C:growth conesq ~ > t C:membrane fractionsq ~ > > t C:integral to membranesq ~ > > t
C:membranesq ~ ; > t
C:MCM complexsq ~ > t C:insoluble fractionsq ~ > t C:nuclear envelopesq ~ > t C:cell somasq ~ > t
C:nucleoplasmsq ~ > t "C:DNA replication factor C complexsq ~ v > t C:axonpppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ > t P:cell cycle arrestt 7050sq ~ > t 0P:induction of apoptosis by intracellular sig...t 8629sq ~ > t +P:negative regulation of cell proliferationt 8285sq ~ > t 0P:regulation of cyclin-dependent protein kina...t 79sq ~ > t 0F:cyclin-dependent protein kinase inhibitor a...t 4861sq ~ > t F:protein bindingt 5515sq ~ > t C:nucleust 5634pppxsq ~ uq ~
sq ~ >t IPR003175t CDIpppppppppxsq ~ uq ~
sq ~ >t CDIt PF02234pppppppppxt P38936t CDN1A_HUMANsq ~ uq ~
sq ~ >t p21sq ~ >t CDK-interacting protein 1sq ~ >t -Melanoma differentiation-associated protein 6sq ~ >t MDA-6ppppppxt Homo sapienst NCOA1sq ~?aa N O %t Nuclear receptor coactivator 1sq ~ uq ~
sq ~ t ENSG00000084676pppppppppxsq ~ uq ~
sq ~ t NCOA1sq ~ t SRC1ppppppppxsq ~ uq ~
@sq ~ t P:signal transductionsq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t /P:transcription from RNA polymerase II promotersq ~ t 0P:regulation of transcription from RNA polyme...sq ~ @a t &P:negative regulation of transcriptionsq ~ E t 0P:positive regulation of transcription, DNA-d...sq ~ u t &P:positive regulation of transcriptionsq ~ t P:transcription, DNA-dependentsq ~ c t P:cell-cell signalingsq ~ x t 0P:positive regulation of transcription from R...sq ~ ` t P:homeostatic processsq ~ t P:response to hypoxiasq ~ F t (P:N-terminal peptidyl-lysine acetylationsq ~ w9 t %P:androgen receptor signaling pathwaysq ~ t P:regulation of apoptosissq ~ > t
P:cell growthsq ~ w8 t %P:estrogen receptor signaling pathwaysq ~ t P:anti-apoptosissq ~ t P:nervous system developmentsq ~ & t P:response to stresssq ~ t 0P:transcription initiation from RNA polymeras...sq ~ O t P:protein amino acid methylationsq ~ t P:lipid metabolic processsq ~ t P:apoptosissq ~ * t P:inflammatory responsesq ~ t P:focal adhesion formationsq ~ = t P:protein complex assemblysq ~ D t 0P:negative regulation of transcription, DNA-d...sq ~ [ t P:cell proliferationsq ~ ] t +P:negative regulation of cell proliferationsq ~ t P:RNA splicingsq ~ Ƹ t P:white fat cell differentiationsq ~ ƅ t P:protein stabilizationsq ~ z t ,P:regulation of steroid biosynthetic processsq ~ ! t P:male gonad developmentsq ~ $ t !P:response to xenobiotic stimulussq ~ % t P:response to virussq ~ V t /P:negative regulation of dendrite morphogenesissq ~ ' t #P:regulation of synaptic plasticitysq ~ t 0P:chromatin-mediated maintenance of transcrip...sq ~ t P:DNA repairsq ~ t P:bile acid metabolic processsq ~ d t P:synaptic transmissionsq ~ t 0P:maintenance of protein localization in nucleussq ~ k t &P:multicellular organismal developmentsq ~ Y t P:protein homotetramerizationsq ~ r t P:primary sex determinationsq ~ | t P:sex differentiationsq ~ G t &P:negative regulation of cell motilitysq ~ ǝ t P:regulation of DNA bindingsq ~ t P:response to nutrientsq ~ t P:digestionsq ~ t P:lymph node developmentsq ~ Ǔ t 0P:positive regulation of transcription factor...sq ~ ƹ t P:brown fat cell differentiationsq ~
t P:steroid metabolic processsq ~ t P:blood coagulationsq ~ ' t P:response to UV-Csq ~ >$ t P:fatty acid transportsq ~ t $P:eye photoreceptor cell developmentsq ~ t (P:positive regulation of gluconeogenesissq ~ b t P:response to starvationsq ~ t 0P:DNA damage response, signal transduction by...sq ~ t +P:glucocorticoid receptor signaling pathwaysq ~ ` t &P:regulation of neuron differentiationsq ~ : t "P:negative regulation of apoptosissq ~ t 0P:positive regulation of gene-specific transc...sq ~ t $P:negative regulation of DNA bindingsq ~ t 0P:negative regulation of transcription factor...sq ~ t 0P:negative regulation of interleukin-12 biosy...sq ~ t 0P:positive regulation of fat cell differentia...sq ~ t P:cellular respirationsq ~ t 0P:positive regulation of protein biosynthetic...sq ~ t "P:regulation of cell proliferationsq ~ t ,P:positive regulation of histone acetylationsq ~ x t P:prostate gland developmentsq ~ ] t P:response to arsenicsq ~ @ t P:histone methylationsq ~ @ t P:histone acetylationsq ~ B t P:protein sumoylationsq ~ K t 0P:cytokine and chemokine mediated signaling p...sq ~ uS t P:microspike biogenesissq ~ vd t $P:negative regulation of cell growthsq ~ w0 t 0P:negative regulation of transforming growth ...sq ~ t -P:positive regulation of fatty acid oxidationsq ~ i t -P:regulation of NF-kappaB import into nucleussq ~ } t 0P:positive regulation of fatty acid beta-oxid...sq ~ p t $P:regulation of protein localizationsq ~ g t 0P:negative regulation of interleukin-8 biosyn...sq ~ [ t P:JAK-STAT cascadesq ~ Q t #P:I-kappaB kinase/NF-kappaB cascadesq ~ t P:potassium ion transportsq ~ t P:cell glucose homeostasissq ~ t P:transportsq ~ t P:xenobiotic metabolic processsq ~ n t P:vitamin metabolic processsq ~ t P:nucleosome disassemblysq ~ 9 t "P:glucocorticoid catabolic processsq ~ t 0P:generation of precursor metabolites and energysq ~ t
P:translationsq ~ t P:mRNA processingsq ~ t P:RNA processingsq ~ t P:chromatin remodelingsq ~ t !P:intracellular protein transportsq ~ { t P:thermoregulationsq ~ t 0P:cell surface receptor linked signal transdu...sq ~ t P:cell cycle arrestsq ~ t P:cell cyclesq ~ ] t +P:mitochondrion organization and biogenesissq ~ + t P:immune responsesq ~ t P:chemotaxissq ~ t P:cell motilitysq ~ t P:induction of apoptosissq ~ < t ,P:protein import into nucleus, translocationsq ~ R t 'P:G1/S transition of mitotic cell cyclesq ~ z t 0P:negative regulation of transcription from R...sq ~ t P:DNA methylationsq ~ t t F:transcription factor activitysq ~ t F:protein bindingsq ~ t $F:transcription coactivator activitysq ~ t ,F:ligand-dependent nuclear receptor activitysq ~ ]
t
F:DNA bindingsq ~ } t F:protein N-terminus bindingsq ~ t #F:thyroid hormone receptor activitysq ~ { t #F:steroid hormone receptor activitysq ~ v t 0F:RNA polymerase II transcription factor acti...sq ~ - t F:sequence-specific DNA bindingsq ~ @ t "F:transcription activator activitysq ~ z t 0F:ligand-regulated transcription factor activitysq ~ t F:transcription factor bindingsq ~ 2 t $F:histone acetyltransferase activitysq ~ t F:androgen receptor bindingsq ~ t $F:transcription corepressor activitysq ~ N t F:zinc ion bindingsq ~ | t !F:retinoic acid receptor activitysq ~ 2 t F:identical protein bindingsq ~ x t F:steroid bindingsq ~ : t F:integrin bindingsq ~ t F:retinoid-X receptor activitysq ~ t "F:glucocorticoid receptor activitysq ~ t F:androgen receptor activitysq ~ t F:signal transducer activitysq ~ t F:RNA helicase activitysq ~ b t F:chromatin bindingsq ~ t %F:protein heterodimerization activitysq ~ t F:protein dimerization activitysq ~ t
F:RNA bindingsq ~ ?{ t 0F:general RNA polymerase II transcription fac...sq ~ vL t F:estrogen receptor activitysq ~ V t F:protein C-terminus bindingsq ~ @G t 0F:RNA polymerase II transcription mediator ac...sq ~ @ t "F:transcription repressor activitysq ~ v t "F:thyroid hormone receptor bindingsq ~ @ t -F:specific transcriptional repressor activitysq ~ B t +F:ligand-dependent nuclear receptor bindingsq ~ C t F:vinculin bindingsq ~ t (F:translation initiation factor activitysq ~ t F:actin bindingsq ~ Y t F:sulfonylurea receptor activitysq ~ c t F:MAP kinase activitysq ~ M t !F:protein domain specific bindingsq ~ @ t F:acetyltransferase activitysq ~ t F:receptor antagonist activitysq ~ y t 0F:RNA polymerase II transcription factor acti...sq ~ Ȯ t F:FATZ 1 bindingsq ~ Ȫ t F:ZASP bindingsq ~ t F:N-acetyltransferase activitysq ~ t F:N-methyltransferase activitysq ~ t F:RNA-dependent ATPase activitysq ~ T t $F:protein methyltransferase activitysq ~ s t "F:structural constituent of musclesq ~ t F:vitamin D3 receptor activitysq ~ j t F:double-stranded DNA bindingsq ~ t F:AF-2 domain bindingsq ~ y t F:MyoD bindingsq ~ x t 0F:specific RNA polymerase II transcription fa...sq ~ 3 t #F:protein homodimerization activitysq ~ u t .F:receptor signaling complex scaffold activitysq ~ s t F:NF-kappaB bindingsq ~ v t 0F:ligand-dependent nuclear receptor transcrip...sq ~ _ t F:transporter activitysq ~ y` t F:heat shock protein bindingsq ~ t !F:glucocorticoid receptor bindingsq ~ t #F:histone acetyltransferase bindingsq ~ J t F:histone deacetylase bindingsq ~ w t F:protein binding, bridgingsq ~ z t F:ubiquitin bindingsq ~ ' t -F:insulin-like growth factor receptor bindingsq ~ t 0F:hematopoietin/interferon-class (D200-domain...sq ~ t 0F:aryl hydrocarbon receptor nuclear transloca...sq ~ y t F:androgen bindingsq ~ v t *F:nitric-oxide synthase regulator activitysq ~ w@ t "F:transcription regulator activitysq ~ $ t C:nucleussq ~ i t C:cytoplasmsq ~ y t C:pseudopodiumsq ~ t C:nuclear chromosomesq ~ % t C:focal adhesionsq ~ t C:nuclear poresq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ ! t .C:DNA-directed RNA polymerase II, core complexsq ~ wA t C:ribonucleoprotein complexsq ~ % t $C:transcription factor TFIID complexsq ~ t
C:nucleoplasmsq ~ u t C:filopodiumsq ~ t C:Bcl3-Bcl10 complexsq ~ t C:dendritic spinesq ~ t 0C:eukaryotic translation initiation factor 3 ...sq ~ B t #C:transcriptional repressor complexsq ~ t C:actin filamentsq ~ @ t C:chromatin remodeling complexsq ~ t C:mitochondrial matrixsq ~ k t C:mitochondrionsq ~ # t C:transcription factor complexsq ~ t C:intracellularsq ~ t C:Bcl3/NF-kappaB2 complexsq ~ > t
C:membranepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t %P:androgen receptor signaling pathwayt 30521sq ~ t 0P:positive regulation of transcription, DNA-d...t 45893sq ~ t F:androgen receptor bindingt 50681sq ~ t F:protein N-terminus bindingt 47485sq ~ t $F:transcription coactivator activityt 3713sq ~ t C:nucleust 5634ppppxsq ~ uq ~
sq ~ t IPR010011t DUF1518sq ~ t IPR001092t HLH_basicsq ~ t IPR014920t Nuc_rcpt_coact_Ncoa-typsq ~ t IPR000014t PASsq ~ t IPR013767t PAS_foldsq ~ t IPR014935t SRC-1sq ~ t IPR008955t Src1_rcpt_coactpppxsq ~ uq ~
sq ~ t DUF1518t PF07469sq ~ t HLHt PF00010sq ~ t Nuc_rec_co-actt PF08815sq ~ t PASt PF00989sq ~ t SRC-1t PF08832pppppxt Q15788t NCOA1_HUMANsq ~ uq ~
sq ~ t NCoA-1sq ~ t Steroid receptor coactivator 1sq ~ t SRC-1sq ~ t RIP160sq ~ t
Protein Hin-2sq ~ t !Renal carcinoma antigen NY-REN-52ppppxt Homo sapienst PRS4sq ~?%g M %t !26S protease regulatory subunit 4sq ~ uq ~
sq ~ Mt ENSG00000100764pppppppppxsq ~ uq ~
sq ~ M t PSMC1pppppppppxsq ~ )uq ~
Psq ~ ƶ M t *P:positive regulation of T cell activationsq ~ M t ,P:regulation of transcription, DNA-dependentsq ~ D M t $P:protein amino acid phosphorylationsq ~ l M t
P:proteolysissq ~ n M t P:ATP-dependent proteolysissq ~ M t P:anti-apoptosissq ~ M t P:caspase activationsq ~ U M t %P:nuclear organization and biogenesissq ~ M t P:signal transductionsq ~ R M t )P:activation of NF-kappaB-inducing kinasesq ~ V M t
P:JNK cascadesq ~ M t P:visual perceptionsq ~ @ M t P:protein ubiquitinationsq ~ v M t )P:ER-associated protein catabolic processsq ~ x M t P:unfolded protein responsesq ~ s M t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ Ƥ M t #P:T cell receptor signaling pathwaysq ~ M t P:double-strand break repairsq ~ M t P:protein polyubiquitinationsq ~
M t 0P:positive regulation of T cell cytokine prod...sq ~ & M t P:response to stresssq ~ x M t -P:retrograde protein transport, ER to cytosolsq ~ M t F:protein bindingsq ~ A M t F:ATPase activitysq ~ M t
F:ATP bindingsq ~ M t #F:ubiquitin-protein ligase activitysq ~ M t $F:transcription coactivator activitysq ~ t M t F:transcription factor activitysq ~ M t F:signal transducer activitysq ~ M t !F:transmembrane receptor activitysq ~ B M t *F:protein serine/threonine kinase activitysq ~ M t &C:proteasome complex (sensu Eukaryota)sq ~ M t 0C:proteasome regulatory particle (sensu Eukar...sq ~ M t C:nucleussq ~ i M t C:cytoplasmsq ~ M t C:cytosolsq ~ M t C:autophagic vacuolesq ~ M t C:Bcl3/NF-kappaB2 complexsq ~ M t C:protein complexsq ~ M t C:microsomesq ~ M t C:endoplasmic reticulumpppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ M t F:ATPase activityt 16887sq ~ M t F:protein bindingt 5515sq ~ M t &C:proteasome complex (sensu Eukaryota)t 502pppppppxsq ~ uq ~
sq ~ Mt IPR005937t 26S_proteasome_P45sq ~ Mt IPR003593t AAA+_ATPase_coresq ~ Mt IPR003959t AAA_ATPase_coresq ~ Mt IPR003960t AAA_ATPase_subppppppxsq ~ uq ~
sq ~ Mt AAAt PF00004pppppppppxt P62191t
PRS4_HUMANsq ~ uq ~
sq ~ Mt P26s4sq ~ Mt Proteasome 26S subunit ATPase 1ppppppppxt Homo sapienst HIF1Asq ~? , , %t Hypoxia-inducible factor 1 alphasq ~ uq ~
sq ~ t ENSG00000100644pppppppppxsq ~ uq ~
sq ~ t HIF1Asq ~ t MOP1ppppppppxsq ~ uq ~
sq ~ t P:signal transductionsq ~ J t .P:regulation of progression through cell cyclesq ~ ] t +P:negative regulation of cell proliferationsq ~ t P:response to hypoxiasq ~ t /P:transcription from RNA polymerase II promotersq ~ t ,P:regulation of transcription, DNA-dependentsq ~ F t (P:N-terminal peptidyl-lysine acetylationsq ~ t P:nervous system developmentsq ~ @ t P:protein ubiquitinationsq ~ t P:cell cycle arrestsq ~ [ t P:cell proliferationsq ~ t P:base-excision repairsq ~ ` t P:homeostatic processsq ~ t P:transcription, DNA-dependentsq ~ t P:anti-apoptosissq ~ D t $P:protein amino acid phosphorylationsq ~ = t P:protein complex assemblysq ~ u t &P:positive regulation of transcriptionsq ~ z t 0P:negative regulation of transcription from R...sq ~ t P:protein localizationsq ~ t P:mitochondrial transportsq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ t P:apoptosissq ~ t P:circadian rhythmsq ~ t P:cell agingsq ~ J t P:response to unfolded proteinsq ~ | t P:sex differentiationsq ~ t $P:central nervous system developmentsq ~ & t P:response to stresssq ~ s t P:spermatogenesissq ~ k t &P:multicellular organismal developmentsq ~ G t P:ER overload responsesq ~ c t P:cell-cell signalingsq ~ t P:cell cyclesq ~ Y t 0P:chromosome organization and biogenesis (sen...sq ~ ! t %P:caspase activation via cytochrome csq ~ $ t P:response to light stimulussq ~ t 0P:DNA damage response, signal transduction by...sq ~ u t 0P:positive regulation of nitric oxide biosynt...sq ~ t 0P:positive regulation of protein catabolic pr...sq ~ t 0P:positive regulation of global transcription...sq ~ E t 0P:positive regulation of transcription, DNA-d...sq ~ x t 0P:positive regulation of transcription from R...sq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ ƅ t P:protein stabilizationsq ~ Ǔ t 0P:positive regulation of transcription factor...sq ~ Ǚ t *P:negative regulation of helicase activitysq ~ ǝ t P:regulation of DNA bindingsq ~ > t P:protein tetramerizationsq ~ t )P:regulation of protein catabolic processsq ~ t )P:cellular response to glucose starvationsq ~ * t P:protein refoldingsq ~ % t P:entrainment of circadian clocksq ~ > t
P:cell growthsq ~ ? t P:phosphorylationsq ~ @a t &P:negative regulation of transcriptionsq ~ @ t P:chromatin modificationsq ~ @ t P:histone acetylationsq ~ uO t P:cell projection biogenesissq ~ vd t $P:negative regulation of cell growthsq ~ w' t &P:regulation of cell redox homeostasissq ~ w8 t %P:estrogen receptor signaling pathwaysq ~ w9 t %P:androgen receptor signaling pathwaysq ~ x t P:prostate gland developmentsq ~ [ t P:protein heterooligomerizationsq ~ t P:transportsq ~ p t P:ubiquitin cyclesq ~ t P:regulation of cell growthsq ~ t P:cell morphogenesissq ~ t -P:positive regulation of cell differentiationsq ~ t P:nucleotide-excision repairsq ~ t P:DNA packagingsq ~ t P:chromatin remodelingsq ~ t
P:translationsq ~ J t +P:N-terminal protein amino acid acetylationsq ~ K t )P:internal protein amino acid acetylationsq ~ l t
P:proteolysissq ~ t P:in utero embryonic developmentsq ~
t F:protein bindingsq ~ t
t F:transcription factor activitysq ~
t $F:transcription coactivator activitysq ~ t
F:ATP bindingsq ~ } t F:protein N-terminus bindingsq ~ M t F:enzyme bindingsq ~ 3 t #F:protein homodimerization activitysq ~ t 0F:aryl hydrocarbon receptor nuclear transloca...sq ~ t %F:protein heterodimerization activitysq ~ t $F:transcription corepressor activitysq ~ 2 t $F:histone acetyltransferase activitysq ~ N t F:zinc ion bindingsq ~ t F:transcription factor bindingsq ~ v t 0F:RNA polymerase II transcription factor acti...sq ~ V t F:protein C-terminus bindingsq ~ ] t
F:DNA bindingsq ~ x t F:TPR domain bindingsq ~ t F:nuclease activitysq ~ t F:endodeoxyribonuclease activitysq ~ t F:ribonuclease H activitysq ~ t F:phosphodiesterase I activitysq ~
t "F:phosphoglycerate kinase activitysq ~ v t *F:nitric-oxide synthase regulator activitysq ~ J t F:protein kinase CK2 activitysq ~ 7 t F:histone deacetylase activitysq ~ t F:DNA strand annealing activitysq ~ T t F:GTPase activitysq ~ - t F:sequence-specific DNA bindingsq ~ t F:metal ion bindingsq ~ J t F:histone deacetylase bindingsq ~ y t F:MyoD bindingsq ~ 2 t F:identical protein bindingsq ~ t F:protein dimerization activitysq ~ t (F:translation initiation factor activitysq ~ t F:androgen receptor bindingsq ~ B t 0F:DNA-(apurinic or apyrimidinic site) lyase a...sq ~ Mr t F:oxygen sensor activitysq ~ t F:N-acetyltransferase activitysq ~ t F:copper ion bindingsq ~ y t F:androgen bindingsq ~ t F:ferrous iron bindingsq ~ @ t F:acetyltransferase activitysq ~ t F:androgen receptor activitysq ~ @k t F:oxidoreductase activitysq ~ @ t "F:transcription activator activitysq ~ t F:signal transducer activitysq ~ MK t +F:small conjugating protein ligase activitysq ~ c t F:MAP kinase activitysq ~ C t 0F:negative regulator of basal transcription a...sq ~ C
t #F:aryl hydrocarbon receptor bindingsq ~ AB t 0F:oxidoreductase activity, acting on paired d...sq ~ t #F:ubiquitin-protein ligase activitysq ~ t #F:uracil DNA N-glycosylase activitysq ~ t F:3'-5' exonuclease activitysq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:cytosolsq ~ t C:insoluble fractionsq ~ t &C:proteasome complex (sensu Eukaryota)sq ~ W t !C:perinuclear region of cytoplasmsq ~ t C:endoplasmic reticulumsq ~ k t C:mitochondrionsq ~ b t C:nucleolussq ~ t
C:nucleoplasmsq ~ t C:stress fibersq ~ v t C:histone deacetylase complexsq ~ t C:nuclear chromosomesq ~ t C:soluble fractionsq ~ t C:plasma membranesq ~ t
C:microtubulesq ~ t 0C:eukaryotic translation initiation factor 3 ...sq ~ ? t C:nuclear matrixsq ~ t
C:ribosomesq ~ $ t C:microtubule-based flagellumsq ~ # t C:transcription factor complexsq ~ t C:neuron projectionppppppxsq ~ uq ~
sq ~ t P:homeostatic processt 42592sq ~ t 0P:positive regulation of transcription from R...t 45944sq ~ t P:response to hypoxiat 1666sq ~ t P:signal transductiont 7165sq ~ t #F:histone acetyltransferase bindingt 35035sq ~ t %F:protein heterodimerization activityt 46982sq ~ t 0F:RNA polymerase II transcription factor acti...t 3705sq ~ t C:transcription factor complext 5667ppxsq ~ uq ~
sq ~ t IPR014887t HIF-1a_CTADsq ~ t IPR001092t HLH_basicsq ~ t IPR001321t HypoxindF1A_PASsq ~ t IPR001610t PACsq ~ t IPR000014t PASsq ~ t IPR013655t PAS_3ppppxsq ~ uq ~
sq ~ t HIF-1a_CTADt PF08778sq ~ t HLHt PF00010sq ~ t PAS_3t PF08447pppppppxt Q16665t HIF1A_HUMANsq ~ uq ~
sq ~ t HIF-1 alphasq ~ t
HIF1 alphasq ~ t ARNT-interacting proteinsq ~ t Member of PAS protein 1sq ~ t 'Basic-helix-loop-helix-PAS protein MOP1pppppxt Homo sapienst NCOA3sq ~?ja1 ; h < %t Nuclear receptor coactivator 3sq ~ uq ~
sq ~ ht ENSG00000124151pppppppppxsq ~ uq ~
sq ~ h t NCOA3sq ~ h t AIB1sq ~ h t RAC3sq ~ h t TRAM1ppppppxsq ~ uq ~
@sq ~
h t P:signal transductionsq ~ E h t 0P:positive regulation of transcription, DNA-d...sq ~ @a h t &P:negative regulation of transcriptionsq ~ x h t 0P:positive regulation of transcription from R...sq ~ h t ,P:regulation of transcription, DNA-dependentsq ~ F h t (P:N-terminal peptidyl-lysine acetylationsq ~ u h t &P:positive regulation of transcriptionsq ~ h t 0P:regulation of transcription from RNA polyme...sq ~ h t P:skeletal developmentsq ~ h t /P:transcription from RNA polymerase II promotersq ~ w9 h t %P:androgen receptor signaling pathwaysq ~ c h t P:cell-cell signalingsq ~ @ h t P:histone acetylationsq ~ w8 h t %P:estrogen receptor signaling pathwaysq ~ [ h t P:cell proliferationsq ~ h t "P:regulation of cell proliferationsq ~ h t P:transcription, DNA-dependentsq ~ & h t P:response to stresssq ~ h t 0P:cell surface receptor linked signal transdu...sq ~ h t P:chemotaxissq ~ > h t
P:cell growthsq ~ h t P:apoptosissq ~ h t P:anti-apoptosissq ~ h t P:induction of apoptosissq ~ ` h t P:homeostatic processsq ~ ǔ h t .P:activation of NF-kappaB transcription factorsq ~ Ǔ h t 0P:positive regulation of transcription factor...sq ~ h t P:response to hypoxiasq ~ C h t P:response to oxidative stresssq ~ Q h t #P:I-kappaB kinase/NF-kappaB cascadesq ~ ] h t P:response to arsenicsq ~ T h t P:I-kappaB phosphorylationsq ~ h t .P:negative regulation of centriole replicationsq ~ D h t 0P:negative regulation of transcription, DNA-d...sq ~ h t 0P:negative regulation of progression through ...sq ~ d h t P:synaptic transmissionsq ~ k h t &P:multicellular organismal developmentsq ~ h t P:nervous system developmentsq ~ h t $P:central nervous system developmentsq ~ K h t P:protein kinase cascadesq ~ h t P:embryonic eye morphogenesissq ~ h t 0P:chromatin-mediated maintenance of transcrip...sq ~ Ƹ h t P:white fat cell differentiationsq ~ Ƥ h t #P:T cell receptor signaling pathwaysq ~ * h t P:inflammatory responsesq ~ + h t P:immune responsesq ~ 8 h t P:cellular defense responsesq ~ V h t /P:negative regulation of dendrite morphogenesissq ~ B h t 0P:DNA damage response, signal transduction by...sq ~ ' h t #P:regulation of synaptic plasticitysq ~ h t P:cell cycle arrestsq ~ h t P:chromosome segregationsq ~ h t P:regulation of mitosissq ~ | h t P:sex differentiationsq ~ h t P:response to nutrientsq ~
h t P:steroid metabolic processsq ~ w0 h t 0P:negative regulation of transforming growth ...sq ~ h t 0P:positive regulation of fat cell differentia...sq ~ k h t P:response to estrogen stimulussq ~ ɗ h t P:defense response to virussq ~ x h t P:prostate gland developmentsq ~ h t 0P:negative regulation of transcription factor...sq ~ ~] h t 0P:positive regulation of aldosterone biosynth...sq ~ p h t $P:regulation of protein localizationsq ~ h t $P:negative regulation of DNA bindingsq ~ s h t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ h t P:fibrinolysissq ~ h t +P:glucocorticoid receptor signaling pathwaysq ~ vd h t $P:negative regulation of cell growthsq ~ K h t 0P:cytokine and chemokine mediated signaling p...sq ~ ` h t &P:regulation of neuron differentiationsq ~ z h t /P:positive regulation of protein ubiquitinationsq ~ ] h t +P:negative regulation of cell proliferationsq ~ !` h t P:epidermis developmentsq ~ ! h t 0P:DNA damage response, signal transduction re...sq ~ % h t $P:anatomical structure morphogenesissq ~ % h t P:response to hormone stimulussq ~ '1 h t P:response to organic substancesq ~ ' h t P:response to UV-Bsq ~ n h t P:vitamin metabolic processsq ~ h t P:regulation of angiogenesissq ~ h t #P:positive regulation of DNA repairsq ~ B h t P:protein sumoylationsq ~ 9 h t "P:positive regulation of apoptosissq ~ h t 0P:negative regulation of fatty acid biosynthe...sq ~ h t P:nucleosome disassemblysq ~ h t P:postreplication repairsq ~ h t P:nucleotide-excision repairsq ~ h t P:DNA repairsq ~ h t 0P:generation of precursor metabolites and energysq ~ P h t P:G1 phase of mitotic cell cyclesq ~ R h t 'P:G1/S transition of mitotic cell cyclesq ~ z h t 0P:negative regulation of transcription from R...sq ~ h t 0P:two-component signal transduction system (p...sq ~ h t 0P:double-strand break repair via homologous r...sq ~ - h t &P:epithelial to mesenchymal transitionsq ~ K h t 'P:complement activation, lectin pathwaysq ~ h t P:chromatin remodelingsq ~ h t 0P:regulation of transcription from RNA polyme...sq ~ h t P:transportsq ~ h t P:xenobiotic metabolic processsq ~ 9 h t "P:glucocorticoid catabolic processsq ~ h t P:lipid metabolic processsq ~ h t P:cell motilitysq ~ l h t
P:proteolysissq ~ O h t P:protein amino acid methylationsq ~ D h t $P:protein amino acid phosphorylationsq ~ = h t P:protein complex assemblysq ~ 9 h t P:protein foldingsq ~ h t P:RNA processingsq ~ h t 0P:transcription initiation from RNA polymeras...sq ~ h t !P:intracellular protein transportsq ~ h t F:protein bindingsq ~ h t $F:transcription coactivator activitysq ~ t h t F:transcription factor activitysq ~ ]
h t
F:DNA bindingsq ~ h t ,F:ligand-dependent nuclear receptor activitysq ~ } h t F:protein N-terminus bindingsq ~ h t $F:transcription corepressor activitysq ~ h t F:signal transducer activitysq ~ 2 h t F:identical protein bindingsq ~ h t F:androgen receptor bindingsq ~ @ h t "F:transcription activator activitysq ~ 2 h t $F:histone acetyltransferase activitysq ~ | h t !F:retinoic acid receptor activitysq ~ h t F:retinoid-X receptor activitysq ~ vL h t F:estrogen receptor activitysq ~ y h t F:MyoD bindingsq ~ b h t F:chromatin bindingsq ~ s h t F:NF-kappaB bindingsq ~ z h t 0F:ligand-regulated transcription factor activitysq ~ h t F:RNA helicase activitysq ~ u h t .F:receptor signaling complex scaffold activitysq ~ x h t F:steroid bindingsq ~ ?{ h t 0F:general RNA polymerase II transcription fac...sq ~ N h t F:zinc ion bindingsq ~ V h t F:protein C-terminus bindingsq ~ { h t #F:steroid hormone receptor activitysq ~ w h t F:protein binding, bridgingsq ~ - h t F:sequence-specific DNA bindingsq ~ h t F:sugar bindingsq ~ h t
F:RNA bindingsq ~ = h t F:tubulin bindingsq ~ h t F:actin bindingsq ~ J h t F:histone deacetylase bindingsq ~ 3 h t #F:protein homodimerization activitysq ~ y h t 0F:RNA polymerase II transcription factor acti...sq ~ v h t 0F:RNA polymerase II transcription factor acti...sq ~ h t F:N-acetyltransferase activitysq ~ h t F:N-methyltransferase activitysq ~ h t F:RNA-dependent ATPase activitysq ~ h t F:receptor antagonist activitysq ~ h t F:protein dimerization activitysq ~ h t %F:protein heterodimerization activitysq ~ h t F:MP kinase activitysq ~ h t F:IkappaB kinase activitysq ~ h t F:vitamin D3 receptor activitysq ~ j h t F:double-stranded DNA bindingsq ~ h t
F:ATP bindingsq ~ B h t *F:protein serine/threonine kinase activitysq ~ = h t F:phosphate bindingsq ~ @ h t "F:transcription repressor activitysq ~ h t #F:thyroid hormone receptor activitysq ~ v{ h t F:estrogen receptor bindingsq ~ h t F:Notch bindingsq ~ y h t F:androgen bindingsq ~ v h t *F:nitric-oxide synthase regulator activitysq ~ M h t !F:protein domain specific bindingsq ~ M h t F:protein kinase bindingsq ~ M h t F:enzyme bindingsq ~ ' h t -F:insulin-like growth factor receptor bindingsq ~ P h t (F:structural constituent of cytoskeletonsq ~ @ h t F:acetyltransferase activitysq ~ h t "F:glucocorticoid receptor activitysq ~ y` h t F:heat shock protein bindingsq ~ h t F:receptor activitysq ~ d h t F:MAP kinase kinase activitysq ~ c h t F:MAP kinase activitysq ~ h t F:androgen receptor activitysq ~ h t !F:glucocorticoid receptor bindingsq ~ h t C:nucleussq ~ i h t C:cytoplasmsq ~ # h t C:transcription factor complexsq ~ h t C:nuclear chromosomesq ~ h t &C:proteasome complex (sensu Eukaryota)sq ~ > h t
C:membranesq ~ k h t C:mitochondrionsq ~ h t +C:outer kinetochore of condensed chromosomesq ~ h t C:intermediate filamentsq ~ { h t #C:histone acetyltransferase complexsq ~ R h t C:gamma-tubulin ring complexsq ~ h t C:nuclear poresq ~ wA h t C:ribonucleoprotein complexsq ~ % h t $C:transcription factor TFIID complexsq ~ B h t #C:transcriptional repressor complexsq ~ h t C:intracellularsq ~ + h t C:holo TFIIH complexsq ~ @ h t C:chromatin remodeling complexsq ~ z h t C:BRCA1-BARD1 complexsq ~ h t C:cytoplasmic partppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ h t %P:androgen receptor signaling pathwayt 30521sq ~ h t 0P:positive regulation of transcription, DNA-d...t 45893sq ~ h t F:androgen receptor bindingt 50681sq ~ h t $F:histone acetyltransferase activityt 4402sq ~ h t F:protein N-terminus bindingt 47485sq ~ h t "F:thyroid hormone receptor bindingt 46966sq ~ h t $F:transcription coactivator activityt 3713sq ~ h t C:nucleust 5634ppxsq ~ uq ~
sq ~ ht IPR010011t DUF1518sq ~ ht IPR001092t HLH_basicsq ~ ht IPR014920t Nuc_rcpt_coact_Ncoa-typsq ~ ht IPR000014t PASsq ~ ht IPR013767t PAS_foldsq ~ ht IPR014935t SRC-1ppppxsq ~ uq ~
sq ~ ht DUF1518t PF07469sq ~ ht HLHt PF00010sq ~ ht Nuc_rec_co-actt PF08815sq ~ ht PASt PF00989sq ~ ht SRC-1t PF08832pppppxt Q9Y6Q9t NCOA3_HUMANsq ~ uq ~
sq ~ ht NCoA-3sq ~ ht -Thyroid hormone receptor activator molecule 1sq ~ ht TRAM-1sq ~ ht ACTRsq ~ ht !Receptor-associated coactivator 3sq ~ ht RAC-3sq ~ ht $Amplified in breast cancer-1 proteinsq ~ ht AIB-1sq ~ ht &Steroid receptor coactivator protein 3sq ~ ht SRC-3sq ~ ht CBP-interacting proteinsq ~ ht pCIPppppppppxt Homo sapienst CCR5sq ~?ii ( &u ) %t C-C chemokine receptor type 5sq ~ uq ~
sq ~ &ut ENSG00000160791sq ~ &ut ENSG00000215778ppppppppxsq ~ uq ~
sq ~ &u t CCR5sq ~ &u t CMKBR5ppppppppxsq ~ uq ~
sq ~ &u t P:chemotaxissq ~
&u t P:signal transductionsq ~ * &u t P:inflammatory responsesq ~ D &u t $P:protein amino acid phosphorylationsq ~ c &u t P:cell-cell signalingsq ~ &u t "P:cellular calcium ion homeostasissq ~ [ &u t P:JAK-STAT cascadesq ~ &u t P:cell motilitysq ~ + &u t P:immune responsesq ~ % &u t P:response to virussq ~ &u t P:cell adhesionsq ~ J &u t .P:regulation of progression through cell cyclesq ~ &u t 0P:negative regulation of adenylate cyclase ac...sq ~ &u t P:exocytosissq ~ 8 &u t P:cellular defense responsesq ~ \ &u t +P:positive regulation of cell proliferationsq ~ $ &u t 0P:elevation of cytosolic calcium ion concentr...sq ~ = &u t %P:integrin-mediated signaling pathwaysq ~ &u t 0P:G-protein coupled receptor protein signalin...sq ~ = &u t P:glutamate transportsq ~ J &u t P:viral genome replicationsq ~ K &u t 0P:cytokine and chemokine mediated signaling p...sq ~ &u t P:caspase activationsq ~ &u t P:apoptosissq ~ J &u t !P:intracellular signaling cascadesq ~ Q &u t #P:I-kappaB kinase/NF-kappaB cascadesq ~ " &u t P:phospholipase C activationsq ~ / &u t P:humoral immune responsesq ~ &u t 0P:G-protein signaling, coupled to cyclic nucl...sq ~ &u t 0P:establishment and/or maintenance of cell po...sq ~ C &u t P:response to oxidative stresssq ~ &u t P:signal complex assemblysq ~ &u t P:regulation of transcriptionsq ~ b &u t *P:cytoskeleton organization and biogenesissq ~ &u t 0P:transmembrane receptor protein tyrosine kin...sq ~ \ &u t *P:tyrosine phosphorylation of STAT proteinsq ~ a &u t !P:Ras protein signal transductionsq ~ &u t P:response to drugsq ~ 9 &u t "P:positive regulation of apoptosissq ~ &u t )P:blood vessel endothelial cell migrationsq ~ &u t P:T cell selectionsq ~
&u t (P:regulation of viral genome replicationsq ~ &u t 0P:positive regulation of interleukin-2 biosyn...sq ~ $ &u t 0P:positive regulation of protein kinase activitysq ~ i &u t P:synaptic vesicle transportsq ~ Ʈ &u t 0P:positive regulation of T cell receptor sign...sq ~ Ư &u t !P:regulation of T cell activationsq ~ ƶ &u t *P:positive regulation of T cell activationsq ~ {, &u t #P:actin cytoskeleton reorganizationsq ~ v &u t P:monocyte differentiationsq ~ v &u t P:platelet formationsq ~ &u t P:nervous system developmentsq ~ J &u t P:mesoderm developmentsq ~ &u t P:response to nutrientsq ~ &u t P:blood coagulationsq ~ ] &u t +P:negative regulation of cell proliferationsq ~ &u t P:regulation of cell shapesq ~ $b &u t P:response to radiationsq ~ & &u t P:organ morphogenesissq ~ : &u t P:protein transportsq ~ u` &u t P:actin filament-based movementsq ~ v &u t P:T cell differentiationsq ~ &u t P:leukocyte migrationsq ~ ) &u t P:acute-phase responsesq ~ &u t 0P:regulation of transcription from RNA polyme...sq ~ &u t 0P:release of sequestered calcium ion into cyt...sq ~ V &u t 'P:G2/M transition of mitotic cell cyclesq ~ z &u t 0P:negative regulation of transcription from R...sq ~ &u t P:activation of MAPK activitysq ~ &u t "P:conjugation with cellular fusionsq ~ &u t
P:cytokinesissq ~ &u t P:angiogenesissq ~ &u t /P:transcription from RNA polymerase II promotersq ~ m &u t )P:membrane protein ectodomain proteolysissq ~ & &u t P:response to stresssq ~ &u t P:muscle contractionsq ~ &u t P:induction of apoptosissq ~ &u t P:anti-apoptosissq ~ &u t
P:endocytosissq ~ &u t P:cellular zinc ion homeostasissq ~ &u t P:calcium ion transportsq ~ &u t P:transportsq ~ I
&u t F:chemokine activitysq ~
&u t F:protein bindingsq ~ &u t F:signal transducer activitysq ~ T &u t F:GTPase activitysq ~ i &u t "F:protein-tyrosine kinase activitysq ~ &u t F:SH2 domain bindingsq ~ @ &u t F:protein kinase activitysq ~ H &u t F:chemoattractant activitysq ~ t &u t F:transcription factor activitysq ~ &u t 0F:hematopoietin/interferon-class (D200-domain...sq ~ : &u t F:coreceptor activitysq ~ M &u t F:protein kinase bindingsq ~ 3 &u t #F:protein homodimerization activitysq ~ &u t F:glycoprotein bindingsq ~ k &u t 0F:non-membrane spanning protein tyrosine kina...sq ~ ǭ &u t F:ATPase bindingsq ~ G &u t F:actin filament bindingsq ~ &u t F:microfilament motor activitysq ~ &u t #F:phosphoinositide 3-kinase bindingsq ~ &u t F:protein anchorsq ~ { &u t !F:CCR2 chemokine receptor bindingsq ~ q &u t F:CD4 receptor bindingsq ~ } &u t F:myosin light chain bindingsq ~ r &u t F:CD8 receptor bindingsq ~ 1 &u t F:MHC class II protein bindingsq ~ &u t F:actin bindingsq ~ M &u t F:enzyme bindingsq ~ l &u t 0F:receptor signaling protein tyrosine kinase ...sq ~ &u t
F:GTP bindingsq ~ Q &u t F:microtubule bindingsq ~ V &u t F:protein C-terminus bindingsq ~ &u t F:transcription factor bindingsq ~ N &u t F:zinc ion bindingsq ~ Q &u t -F:extracellular matrix structural constituentsq ~ &u t F:receptor bindingsq ~ V &u t F:chemokine receptor activitysq ~ r &u t /F:protein serine/threonine phosphatase activitysq ~ &u t !F:transmembrane receptor activitysq ~ &u t F:enzyme inhibitor activitysq ~ A &u t F:ATPase activitysq ~ @ &u t "F:transcription activator activitysq ~ @n &u t #F:C-X-C chemokine receptor activitysq ~ i &u t C:cytoplasmsq ~ &u t C:extracellular spacesq ~ &u t C:soluble fractionsq ~ &u t C:plasma membranesq ~ &u t C:nucleussq ~ &u t C:integral to plasma membranesq ~ > &u t C:integral to membranesq ~ &u t C:cytosolsq ~ &u t "C:heterotrimeric G-protein complexsq ~ &u t C:pericentriolar materialsq ~ &u t C:cytoskeletonsq ~ &u t &C:proteasome complex (sensu Eukaryota)sq ~ &u t C:contractile ringsq ~ &u t C:postsynaptic membranesq ~ z &u t C:leading edgesq ~ } &u t C:cleavage furrowsq ~ u &u t C:T cell receptor complexsq ~ &u t C:extracellular regionsq ~ &u t C:rufflesq ~ &u t C:membrane fractionsq ~ &u t C:stress fibersq ~ A &u t C:lipid raftsq ~ &u t C:protein complexpppppppppppppxsq ~ uq ~
sq ~ &u t P:inflammatory responset 6954sq ~ &u t P:immune responset 6955sq ~ &u t 0P:G-protein coupled receptor protein signalin...t 7186sq ~ &u t 0P:elevation of cytosolic calcium ion concentr...t 7204sq ~ &u t P:chemotaxist 6935sq ~ &u t P:cellular defense responset 6968sq ~ &u t P:cell-cell signalingt 7267sq ~ &u t +F:phosphoinositide phospholipase C activityt 4435sq ~ &u t F:coreceptor activityt 15026sq ~ &u t !F:C-C chemokine receptor activityt 16493sq ~ &u t F:actin bindingt 3779sq ~ &u t C:integral to plasma membranet 5887sq ~ &u t "C:external side of plasma membranet 9897sq ~ &u t
C:endosomet 5768ppppppxsq ~ uq ~
sq ~ &ut IPR002240t CC_5_rcptsq ~ &ut IPR000355t Chmkine_rcptsq ~ &ut IPR000276t GPCR_Rhodpsnpppppppxsq ~ uq ~
sq ~ &ut 7tm_1t PF00001pppppppppxt P51681t
CCR5_HUMANsq ~ uq ~
sq ~ &ut C-C CKR-5sq ~ &ut CC-CKR-5sq ~ &ut CCR-5sq ~ &ut CCR5sq ~ &ut HIV-1 fusion coreceptorsq ~ &ut CHEMR13sq ~ &ut
CD195 antigenpppxt Homo sapienst PLK1sq ~?O 3 E 4 %t $Serine/threonine-protein kinase PLK1sq ~ uq ~
sq ~ Et ENSG00000166851pppppppppxsq ~ uq ~
sq ~ E t PLK1sq ~ E t PLKppppppppxsq ~ uq ~
sq ~ [ E t P:cell proliferationsq ~ E t ,P:regulation of transcription, DNA-dependentsq ~ k E t &P:multicellular organismal developmentsq ~ E t P:regulation of mitosissq ~ E t P:signal transductionsq ~ E t P:cell agingsq ~ o E t /P:ubiquitin-dependent protein catabolic processsq ~ E t P:anti-apoptosissq ~ J E t .P:regulation of progression through cell cyclesq ~ t E t P:DNA replicationsq ~ E t P:nucleotide-excision repairsq ~ O E t 0P:regulation of cyclin-dependent protein kina...sq ~ E t /P:transcription from RNA polymerase II promotersq ~ E t P:cell cycle arrestsq ~ ! E t 0P:DNA damage response, signal transduction re...sq ~ E t 0P:traversing start control point of mitotic c...sq ~ E t -P:regulation of S phase of mitotic cell cyclesq ~ E t P:base-excision repairsq ~ E t 0P:mitotic cell cycle spindle assembly checkpointsq ~ E t P:cell cyclesq ~ G E t P:ER overload responsesq ~ > E t !P:response to DNA damage stimulussq ~ E t P:induction of apoptosissq ~ E t P:lipid metabolic processsq ~ E t P:calcium ion transportsq ~ E t "P:cellular calcium ion homeostasissq ~ E t !P:intracellular protein transportsq ~ E t P:nucleocytoplasmic transportsq ~ E t P:double-strand break repairsq ~ E t P:cell motilitysq ~ & E t P:response to stresssq ~ E t 0P:transcription-coupled nucleotide-excision r...sq ~ E t P:centrosome cyclesq ~ E t 0P:regulation of progression through mitotic c...sq ~ U E t P:regulation of phosphorylationsq ~ E t 0P:DNA damage response, signal transduction by...sq ~ s E t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ k E t P:response to estrogen stimulussq ~ E t (P:protein amino acid autophosphorylationsq ~ 6 E t 0P:regulation of mitochondrial membrane permea...sq ~ E t 0P:negative regulation of epithelial cell prol...sq ~ ǔ E t .P:activation of NF-kappaB transcription factorsq ~ Ǚ E t *P:negative regulation of helicase activitysq ~ > E t P:protein tetramerizationsq ~ E t +P:natural killer cell mediated cytotoxicitysq ~ E t P:ribosome assemblysq ~ E t )P:cellular response to glucose starvationsq ~ E t P:phototransductionsq ~ E t P:long-term memorysq ~ E t P:protein localizationsq ~ ] E t +P:negative regulation of cell proliferationsq ~ ! E t %P:caspase activation via cytochrome csq ~ E t 0P:negative regulation of ubiquitin ligase act...sq ~ vd E t $P:negative regulation of cell growthsq ~ E t P:cytokinesis during cell cyclesq ~ ; E t P:response to genisteinsq ~ @ E t 0P:negative regulation of mammary gland epithe...sq ~ b E t P:centrosome duplicationsq ~ E t P:DNA repairsq ~ ~ E t P:DNA replication initiationsq ~ E t P:regulation of apoptosissq ~ E t -P:meiotic spindle organization and biogenesissq ~ V E t 'P:G2/M transition of mitotic cell cyclesq ~ M E t P:DNA damage checkpointsq ~ E t P:brain developmentsq ~ E t P:mitotic spindle elongationsq ~ y E t P:DNA topological changesq ~ E t F:protein bindingsq ~ E t
F:RNA bindingsq ~ t E t F:transcription factor activitysq ~ O E t F:endopeptidase activitysq ~ ] E t
F:DNA bindingsq ~ @ E t F:protein kinase activitysq ~ E t F:signal transducer activitysq ~ N E t F:zinc ion bindingsq ~ E t
F:ATP bindingsq ~ E t %F:protein heterodimerization activitysq ~ u E t F:chaperone regulator activitysq ~ @ E t "F:transcription activator activitysq ~ E t 0F:Ras guanyl-nucleotide exchange factor activitysq ~ B E t *F:protein serine/threonine kinase activitysq ~ E t F:nuclease activitysq ~ x E t F:Tat protein bindingsq ~ E t F:microtubule motor activitysq ~ NJ E t F:unfolded protein bindingsq ~ s E t F:NF-kappaB bindingsq ~ } E t F:protein N-terminus bindingsq ~ E t F:3'-5' DNA helicase activitysq ~ E t F:gamma-tubulin bindingsq ~ 3 E t #F:protein homodimerization activitysq ~ M E t F:enzyme bindingsq ~ 0 E t F:MHC class I protein bindingsq ~ ^ E t F:DNA helicase activitysq ~ d E t F:damaged DNA bindingsq ~ E t $F:transcription coactivator activitysq ~ !N E t +F:phosphatidylinositol transporter activitysq ~ i E t "F:protein-tyrosine kinase activitysq ~ k E t 0F:non-membrane spanning protein tyrosine kina...sq ~ E t F:calcium ion bindingsq ~ E t F:copper ion bindingsq ~ E t F:DNA strand annealing activitysq ~ P E t (F:structural constituent of cytoskeletonsq ~ E t F:DNA-dependent ATPase activitysq ~ E t F:transcription factor bindingsq ~ u E t 'F:protein tyrosine phosphatase activitysq ~ E t &C:proteasome complex (sensu Eukaryota)sq ~
E t C:nucleussq ~ i E t C:cytoplasmsq ~ b E t C:nucleolussq ~ E t C:centrosomesq ~ E t +C:proteasome core complex (sensu Eukaryota)sq ~ E t C:spindlesq ~ E t C:spindle pole bodysq ~ E t C:chromatinsq ~ E t C:endoplasmic reticulumsq ~ E t
C:nucleoplasmsq ~ E t C:membrane fractionsq ~ E t &C:alpha DNA polymerase:primase complexsq ~ u E t C:secretory granulesq ~ M E t
C:synaptosomesq ~ @ E t
C:PML bodysq ~ ? E t C:nuclear matrixsq ~ E t C:polar microtubulesq ~ > E t
C:membranesq ~ E t
C:polysomesq ~ E t C:cytoskeletonsq ~ E t C:plasma membranesq ~ E t C:kinesin complexsq ~ E t
C:kinetochoresq ~ E t C:extracellular spacesq ~ + E t C:holo TFIIH complexsq ~ 9 E t C:BRCA2-MAGE-D1 complexsq ~ E t C:gamma-tubulin complexsq ~ k E t C:mitochondrionsq ~ E t C:multivesicular bodysq ~ E t C:insoluble fractionsq ~ E t C:condensed nuclear chromosomesq ~ E t C:Golgi apparatussq ~ E t C:protein complexsq ~ ; E t
C:MCM complexppppppppppppppppppppxsq ~ uq ~
sq ~ E t P:cell proliferationt 8283sq ~ E t P:mitosist 7067sq ~ E t .P:regulation of progression through cell cyclet 74sq ~ E t F:protein bindingt 5515sq ~ E t *F:protein serine/threonine kinase activityt 4674sq ~ E t C:centrosomet 5813ppppxsq ~ uq ~
sq ~ Et IPR015728t Polo-like_kinasesq ~ Et IPR000959t POLO_boxsq ~ Et IPR000719t Prot_kinase_coresq ~ Et IPR008271t Ser_thr_pkin_ASsq ~ Et IPR002290t Ser_thr_pkinasepppppxsq ~ uq ~
sq ~ Et Pkinaset PF00069sq ~ Et POLO_boxt PF00659ppppppppxt P53350t
PLK1_HUMANsq ~ uq ~
sq ~ Et Polo-like kinase 1sq ~ Et PLK-1sq ~ Et "Serine/threonine-protein kinase 13sq ~ Et STPK13ppppppxt Homo sapienst PRKN2sq ~?Et]> ! 1T " %t "E3 ubiquitin-protein ligase parkinsq ~ uq ~
sq ~ 1Tt ENSG00000185345pppppppppxsq ~ uq ~
sq ~ 1T t PARK2sq ~ 1T t PRKNppppppppxsq ~ huq ~
sq ~ 1T t P:cell adhesionsq ~ U 1T t 0P:regulation of G-protein coupled receptor pr...sq ~ uP 1T t P:lamellipodium biogenesissq ~ @ 1T t P:protein modification processsq ~ l 1T t
P:proteolysissq ~ o 1T t /P:ubiquitin-dependent protein catabolic processsq ~ s 1T t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ @ 1T t P:protein ubiquitinationsq ~ 1T t P:cell motilitysq ~ 1T t
P:cytokinesissq ~ 1T t P:nervous system developmentsq ~ 1T t P:axon guidancesq ~ 1T t $P:central nervous system developmentsq ~ 1T t P:learning and/or memorysq ~ d 1T t P:synaptic transmissionsq ~ / 1T t P:glutamate signaling pathwaysq ~ 1T t 0P:G-protein coupled receptor protein signalin...sq ~ 1T t 0P:establishment and/or maintenance of cell po...sq ~ j 1T t 0P:negative regulation of progression through ...sq ~ 1T t P:meiotic prophase Isq ~ 1T t P:cell cyclesq ~ g 1T t P:actin filament organizationsq ~ * 1T t P:inflammatory responsesq ~ 1T t 0P:transmembrane receptor protein tyrosine kin...sq ~ ! 1T t P:apoptotic programsq ~ ' 1T t #P:regulation of synaptic plasticitysq ~ P 1T t *P:regulation of neurotransmitter secretionsq ~ u 1T t &P:positive regulation of transcriptionsq ~ ! 1T t P:apical junction assemblysq ~ 1T t +P:natural killer cell mediated cytotoxicitysq ~ N 1T t 0P:long-term strengthening of neuromuscular ju...sq ~ 1T t 0P:positive regulation of Rho protein signal t...sq ~ {W 1T t P:G1/S transition checkpointsq ~ {) 1T t $P:ruffle organization and biogenesissq ~ x 1T t 0P:cortical actin cytoskeleton organization an...sq ~ v 1T t )P:ER-associated protein catabolic processsq ~ v 1T t 'P:negative regulation of cell migrationsq ~ uY 1T t P:actin filament polymerizationsq ~ C 1T t P:regulation of exocytosissq ~ ? 1T t P:cell-cell adhesionsq ~ > 1T t P:synaptic vesicle targetingsq ~ 1T t 0P:negative regulation of receptor mediated en...sq ~ 1T t P:anti-apoptosissq ~ 1T t P:dopamine metabolic processsq ~ 1T t P:endothelial cell proliferationsq ~ 1T t P:inactivation of MAPK activitysq ~ 1T t P:DNA repairsq ~ 1T t /P:transcription from RNA polymerase II promotersq ~ 1T t P:protein import into nucleussq ~ 1T t P:lipid metabolic processsq ~ 1T t P:transportsq ~ 1T t P:apoptosissq ~ M 1T t P:DNA damage checkpointsq ~ 1T t F:protein bindingsq ~ T 1T t F:GTPase activitysq ~ 1T t F:signal transducer activitysq ~ w 1T t F:caspase activitysq ~ 1T t F:GTPase activator activitysq ~ ! 1T t F:guanylate kinase activitysq ~ N 1T t F:structural molecule activitysq ~ 1T t #F:ubiquitin-protein ligase activitysq ~ 2 1T t F:identical protein bindingsq ~ M 1T t F:phosphatase bindingsq ~ M 1T t F:protein kinase bindingsq ~ M 1T t F:enzyme bindingsq ~ l 1T t 0F:N-methyl-D-aspartate selective glutamate re...sq ~ B 1T t %F:G-protein coupled receptor activitysq ~ x 1T t F:GTP-dependent protein bindingsq ~ 1T t F:alpha-catenin bindingsq ~ q 1T t %F:phosphoprotein phosphatase activitysq ~ d 1T t F:damaged DNA bindingsq ~ t 1T t F:transcription factor activitysq ~ 1T t !F:transcription cofactor activitysq ~ A 1T t F:hydrolase activitysq ~ 0 1T t F:MHC class I protein bindingsq ~ V 1T t F:protein C-terminus bindingsq ~ 1T t F:cytoskeletal protein bindingsq ~ 1T t F:3'-5' exonuclease activitysq ~ !X 1T t F:Ran GTPase bindingsq ~ ! 1T t F:caspase activator activitysq ~ @~=@ q ~ sq ~1 @g @ q ~sq ~1 @^ @ q ~sq ~1 @} @z q ~@sq ~1 @uw @~ q ~sq ~1 @u @} q ~sq ~1 @h @} q ~sq ~1 @q? @w" q ~sq ~1 @} @x q ~ sq ~1 @ @t q ~ Psq ~1 @d @d q ~ "sq ~1 @uR@ @wy` q ~ sq ~1 @p @k` q ~ sq ~1 @_ @( q ~$sq ~1 @rP @ q ~$wsq ~1 @cs @]r q ~&Nsq ~1 @H @h q ~(\sq ~1 @S@ @8 q ~(sq ~1 @a @v q ~*msq ~1 @` @4 q ~,lsq ~1 @xc @8@ q ~-sq ~1 @v @ q ~/Ssq ~1 @{ @ q ~0_sq ~1 @q @ xx