sr-cic.cytoscape.plugin.util.CICPluginSesionData LBookmarktLjava/util/HashMap;LGlobEdgq~LGlobNodq~LGonavq~LHelpnavq~LHidedataq~L InterpronavtLjava/lang/Object;LMetnavq~LPfamnavq~LPositionq~xpsrjava.util.HashMap`F loadFactorI thresholdxp?@ wt2srjava.util.Vectorٗ}[;IcapacityIncrementI elementCount[ elementDatat[Ljava/lang/Object;xpur[Ljava.lang.Object;Xs)lxp ppppppppppxxsq~?@ wt2sq~?@w IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA1 (2) PLK1sq~Epppsq~uq~ sq~o%0t BioGRID HPRD t'Feng Y et al. (2001) Cell Growth Differtin vivotHPRD - BioGRID sq~J3 tc BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppppxtHPRD - BioGRID ptPSB5 (1) ADRM1sq~'cpppsq~uq~ sq~96 untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptPRS6B (1) PSD13sq~I tpppsq~uq~ sq~un"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt1433Z (1) NDKBsq~Qpppsq~uq~ sq~ZM`%tn MINT t!Meek SE et al. (2004) J Biol Chemt pull downtMINT pppppppppxtMINT pt PSA6 (1) PSA4sq~pppsq~uq~ sq~S$`%tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt pull downtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT pt PSA5 (1) PSB3sq~J%pppsq~uq~ sq~T\unts IntAct t,Claverol S et al. (2002) Mol Cell Proteomicst"affinity chromatography technologytIntAct pppppppppxtIntAct ptK1C15 (1) PSA1sq~0pppsq~uq~ sq~Jʪ6t IntAct MINT BioGRID HPRD tRual JF et al. (2005) Naturettwo hybrid pooling approachtHPRD - IntAct - MINT - BioGRID pppppppppxtHPRD - IntAct - MINT - BioGRID pt PSD11 (1) PTNsq~sEpppsq~uq~ sq~nĥʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT ptRIPK2 (1) RIPK2sq~LLpppsq~uq~ sq~<3t IntAct MINT t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct - MINT pppppppppxtIntAct - MINT ptPSMD4 (1) PSB1sq~/(pppsq~uq~ sq~BP$]untn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT pt PAK2 (1) PSA1sq~Dpppsq~uq~ sq~Tunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt1B42 (1) NDUS1sq~Ps%pppsq~uq~ sq~*unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PAK2 (1) PSA2sq~Dpppsq~uq~ sq~[<unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt CCNH (1) PSA1sq~0pppsq~uq~ sq~Jʪ2t> IntAct BioGRID HPRD tRual JF et al. (2005) Naturettwo hybrid pooling approachtHPRD - IntAct - BioGRID pppppppppxtHPRD - IntAct - BioGRID ptPSMD4 (1) PSB7sq~/#pppsq~uq~ sq~BP$^untn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT ptCIAO1 (1) FBRLsq~Mw&pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt1433Z (1) HSPB1sq~E%pppsq~uq~ sq~ZM`%tn MINT t!Meek SE et al. (2004) J Biol Chemt pull downtMINT pppppppppxtMINT ptAURKB (1) AURKBsq~bbpppsq~uq~ sq~谭SMq% td BioGRID t$Gassmann R et al. (2004) J Cell Biolt western blottBioGRID pppppppppxtBioGRID ptQ96DE8 (1) PSB5sq~+'pppsq~uq~ sq~96 untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptECBP2 (1) ECBP2sq~pppsq~uq~ sq~JTY4t: MINT BioGRID HPRD tRual JF et al. (2005) Naturet two hybridtHPRD - MINT - BioGRID pppppppppxtHPRD - MINT - BioGRID ptPSMD3 (1) PSA4sq~spppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptNFKB2 (1) PSD13sq~tpppsq~uq~ sq~z3t IntAct MINT t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct - MINT pppppppppxtIntAct - MINT pt1433Z (2) VIMEsq~Epppsq~uq~ sq~ZM`%tn MINT t!Meek SE et al. (2004) J Biol Chemt pull downtMINT sq~ %0t BioGRID HPRD t#Tzivion G et al. (2000) J Biol Chemtin vivotHPRD - BioGRID ppppppppxtHPRD - MINT - BioGRID pt PSB9 (3) PSA2sq~)pppsq~uq~ sq~>P'% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P'% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID sq~kT'unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct pppppppxtIntAct - BioGRID ptKCD17 (2) KCD17sq~0V0Vpppsq~uq~ sq~Jw`%6t IntAct MINT BioGRID HPRD tRual JF et al. (2005) Naturet pull downtHPRD - IntAct - MINT - BioGRID sq~Jwʪ6t IntAct MINT BioGRID HPRD tRual JF et al. (2005) Naturettwo hybrid pooling approachtHPRD - IntAct - MINT - BioGRID ppppppppxtHPRD - IntAct - MINT - BioGRID pt XRN2 (2) IF6sq~@A8pppsq~uq~ sq~k$YtH IntAct BIND HPRD t!Lehner B et al. (2004) Genome Rest two hybridtBIND - HPRD - IntAct sq~J$3 tj BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppppxtBIND - HPRD - IntAct - BioGRID ptPRS6B (1) PSD11sq~I spppsq~uq~ sq~Vun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptPRS4 (1) RRMJ1sq~Mt,pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSMD1 (1) PRS4sq~DMpppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptHSPB1 (3) CRYABsq~E%Upppsq~uq~ sq~gN`%$t MINT BioGRID tFu L et al. (2002) J Biol Chemt pull downtMINT - BioGRID sq~N%0t BioGRID HPRD t Kato K et al. (1992) J Biol Chemtin vivotHPRD - BioGRID sq~N%0t BioGRID HPRD t Kato K et al. (1992) J Biol Chemtin vitrotHPRD - BioGRID pppppppxtHPRD - MINT - BioGRID ptPSB9 (3) NCOA1sq~)pppsq~uq~ sq~RR`%tn MINT tZhang H et al. (2006) EMBO Jt pull downtMINT sq~RRYtn MINT tZhang H et al. (2006) EMBO Jt two hybridtMINT sq~RRuntn MINT tZhang H et al. (2006) EMBO Jtanti bait coimmunoprecipitationtMINT pppppppxtMINT ptSOMA (1) PRS6Asq~S{pppsq~uq~ sq~?unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSB9 (3) NCOA3sq~)hpppsq~uq~ sq~RQ`%tn MINT tZhang H et al. (2006) EMBO Jt pull downtMINT sq~RQYtn MINT tZhang H et al. (2006) EMBO Jt two hybridtMINT sq~RQuntn MINT tZhang H et al. (2006) EMBO Jtanti bait coimmunoprecipitationtMINT pppppppxtMINT pt EZH2 (1) PSB6sq~1$&pppsq~uq~ sq~nyʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT ptADRM1 (1) UBQL1sq~cKrpppsq~uq~ sq~a%yt IntAct HPRD tLim J et al. (2006) Cellttwo hybrid arraytHPRD - IntAct pppppppppxtHPRD - IntAct pt PSA2 (2) PSB8sq~@pppsq~uq~ sq~>P_% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P_% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID ptIKBE (1) GRP78sq~pppsq~uq~ sq~y3ts IntAct t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct pppppppppxtIntAct ptPSD13 (1) PSMD1sq~tDpppsq~uq~ sq~I3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID pppppppppxtBioGRID pt PSA2 (2) PSB6sq~&pppsq~uq~ sq~>P\% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P\% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID pt PSA7 (2) PRS4sq~Mpppsq~uq~ sq~Z%0t BioGRID HPRD t6Hartmann-Petersen R et al. (2001) Arch Biochem Biophystin vitrotHPRD - BioGRID sq~ZY0t BioGRID HPRD t6Hartmann-Petersen R et al. (2001) Arch Biochem Biophyst two hybridtHPRD - BioGRID ppppppppxtHPRD - BioGRID pt PSA2 (2) PSB2sq~pppsq~uq~ sq~>P9% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P9% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID pt NDKB (2) NDKBsq~QQpppsq~uq~ sq~}[Yth HPRD t&MacDonald NJ et al. (1993) J Biol Chemt two hybridtHPRD sq~t[%(t BioGRID BIND t Webb PA et al. (1995) J Mol Bioltin vitrotBIND - BioGRID ppppppppxtBIND - HPRD - BioGRID pt PSB7 (1) PSB4sq~#Qpppsq~uq~ sq~kT'unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSB7 (1) PSB3sq~#%pppsq~uq~ sq~r?wYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct pt PSB7 (1) PSB6sq~#&pppsq~uq~ sq~r?yYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct pt PSB7 (1) PSB5sq~#'pppsq~uq~ sq~r?{Yts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct pt PASK (1) FBRLsq~t&pppsq~uq~ sq~[un"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptNFKB2 (1) HS90Bsq~pppsq~uq~ sq~3t IntAct MINT t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct - MINT pppppppppxtIntAct - MINT ptFANCA (1) SGK1sq~Ppppsq~uq~ sq~?&NDY tc BioGRID t$Reuter TY et al. (2003) Exp Cell Rest two hybridtBioGRID pppppppppxtBioGRID ptESR1 (1) TNR14sq~Fpppsq~uq~ sq~l,Yth HPRD tHu YC et al. (2002) J Biol Chemt two hybridtHPRD pppppppppxtHPRD ptTFE3 (1) PSMD1sq~Q9Dpppsq~uq~ sq~Zunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt VINC (1) RUXFsq~@VA3pppsq~uq~ sq~`%tm BIND tde Hoog CL et al. (2004) Celltmolecular interactiontBIND pppppppppxtBIND ptIKBE (3) NFKB2sq~pppsq~uq~ sq~)3tB IntAct MINT DIP t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtDIP - IntAct - MINT sq~%_)%0t BioGRID HPRD t Li Z et al. (1997) Mol Cell Bioltin vivotHPRD - BioGRID sq~%_)%0t BioGRID HPRD t Li Z et al. (1997) Mol Cell Bioltin vitrotHPRD - BioGRID pppppppxt%DIP - HPRD - IntAct - MINT - BioGRID ptPSD13 (1) SOMAsq~tSpppsq~uq~ sq~,unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptESR1 (3) GRIP1sq~{pppsq~uq~ sq~  t`%tn MINT t null (0) nullt pull downtMINT sq~ O tYth HPRD t$Teyssier C et al. (2001) J Biol Chemt two hybridtHPRD sq~ O t%th HPRD t$Teyssier C et al. (2001) J Biol Chemtin vivotHPRD pppppppxt HPRD - MINT pt AAKB1 (1) IF6sq~PA8pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptNCOA1 (1) NCOA3sq~hpppsq~uq~ sq~ Ytn MINT tZhang Y et al. (2007) EMBO Jt two hybridtMINT pppppppppxtMINT ptPRS6A (1) HIF1Asq~{pppsq~uq~ sq~gVq%0t BioGRID HPRD tCorn PG et al. (2003) Nat Genett western blottHPRD - BioGRID pppppppppxtHPRD - BioGRID pt PSB9 (1) POMPsq~)"pppsq~uq~ sq~r?Yts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct ptIKKE (1) RIPK5sq~PQ)pppsq~uq~ sq~un"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt TNIK (1) PSA1sq~d pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptEIF1B (1) PSD13sq~Ptpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt1433Z (1) PSB3sq~%pppsq~uq~ sq~ZM`%tn MINT t!Meek SE et al. (2004) J Biol Chemt pull downtMINT pppppppppxtMINT pt PSA2 (2) PSB1sq~(pppsq~uq~ sq~>P^% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P^% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID pt PSA7 (1) PSB4sq~Qpppsq~uq~ sq~Taunts IntAct t,Claverol S et al. (2002) Mol Cell Proteomicst"affinity chromatography technologytIntAct pppppppppxtIntAct pt PSA7 (1) PSB3sq~%pppsq~uq~ sq~2R3ts IntAct t Koch HB et al. (2007) Cell Cyclettandem affinity purificationtIntAct pppppppppxtIntAct pt CCNH (1) ESR1sq~0pppsq~uq~ sq~(Yth HPRD t%Talukder AH et al. (2003) J Biol Chemt two hybridtHPRD pppppppppxtHPRD pt PSA2 (1) PSA5sq~Jpppsq~uq~ sq~S$ܒ,ts IntAct t!Apcher GS et al. (2004) FEBS Letttcosedimentation in solutiontIntAct pppppppppxtIntAct pt SGK1 (1) PSA6sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptTRAF6 (2) PSB5sq~T'pppsq~uq~ sq~37t IntAct MINT DIP BioGRID HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationt%DIP - HPRD - IntAct - MINT - BioGRID sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct ppppppppxt%DIP - HPRD - IntAct - MINT - BioGRID ptPSD13 (1) PSA3sq~tpppsq~uq~ sq~Jp3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID pppppppppxtBioGRID ptPSD13 (1) PSA1sq~tpppsq~uq~ sq~J3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID pppppppppxtBioGRID ptPSD13 (1) PSA7sq~tpppsq~uq~ sq~K,3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID pppppppppxtBioGRID pt PSA3 (1) HHEXsq~2pppsq~uq~ sq~õ%th HPRD tBess KL et al. (2003) Biochem Jtin vitrotHPRD pppppppppxtHPRD ptPSD13 (1) PSA6sq~tpppsq~uq~ sq~J3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID pppppppppxtBioGRID ptPSMD6 (1) HSPB1sq~QE%pppsq~uq~ sq~]junts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptEXOS6 (1) PSB1sq~(pppsq~uq~ sq~kͿY(t BioGRID BIND t!Lehner B et al. (2004) Genome Rest two hybridtBIND - BioGRID pppppppppxtBIND - BioGRID ptCRCM (1) PSD13sq~&gtpppsq~uq~ sq~9unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptFBX11 (1) PSA6sq~Fpppsq~uq~ sq~Zunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA3 (2) EGR1sq~pppsq~uq~ sq~W%0t BioGRID HPRD t)Bae MH et al. (2002) Biochim Biophys Actatin vivotHPRD - BioGRID sq~WY0t BioGRID HPRD t)Bae MH et al. (2002) Biochim Biophys Actat two hybridtHPRD - BioGRID ppppppppxtHPRD - BioGRID pt PSA7 (1) PSA5sq~Jpppsq~uq~ sq~S$`%tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt pull downtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT pt 1B42 (1) MCM6sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt CRCM (1) IF6sq~&gA8pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPRS4 (2) PSD13sq~Mtpppsq~uq~ sq~63 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT ppppppppxtMINT - BioGRID ptCDN1A (1) DIPAsq~>0Opppsq~uq~ sq~Jʪ2t> IntAct BioGRID HPRD tRual JF et al. (2005) Naturettwo hybrid pooling approachtHPRD - IntAct - BioGRID pppppppppxtHPRD - IntAct - BioGRID ptTRAF6 (2) PSA1sq~Tpppsq~uq~ sq~3t IntAct MINT t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct - MINT sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct ppppppppxtIntAct - MINT ptPSA2 (2) PSB10sq~pppsq~uq~ sq~>PZ% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>PZ% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID ptSTX11 (1) PSA3sq~Knpppsq~uq~ sq~nwʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT ptPSB7 (1) Q5JNW7sq~#$pppsq~uq~ sq~r?uYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct ptPSMD4 (1) ADRM1sq~/cpppsq~uq~ sq~BP$Luntn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT ptPSMD1 (1) PRS6Asq~D{pppsq~uq~ sq~Yth HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolt two hybridtHPRD pppppppppxtHPRD ptRIPK2 (1) PSB5sq~L'pppsq~uq~ sq~Y|unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptSOMA (1) PSD12sq~Stpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSA2 (2) KIF3Csq~d0pppsq~uq~ sq~>P[% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P[% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID ptPSMD6 (1) PSMD1sq~QDpppsq~uq~ sq~Xun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptRRMJ1 (1) PSMD3sq~t,spppsq~uq~ sq~]unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt TFE3 (1) TFE3sq~Q9Q9pppsq~uq~ sq~4%0t BioGRID HPRD t"Beckmann H et al. (1991) Genes Devtin vivotHPRD - BioGRID pppppppppxtHPRD - BioGRID pt ATN1 (1) BAT2sq~DDpppsq~uq~ sq~aʖYtI IntAct MINT HPRD tLim J et al. (2006) Cellt two hybridtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT ptPSMD6 (1) PSMD3sq~Qspppsq~uq~ sq~Wun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt PAK2 (1) PSB7sq~D#pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptHS90B (1) FBRLsq~&pppsq~uq~ sq~Yth HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolt two hybridtHPRD pppppppppxtHPRD ptPRKN2 (2) VINCsq~1T@Vpppsq~uq~ sq~` q%tm BIND tde Hoog CL et al. (2004) Celltmolecular interactiontBIND sq~J q3 tc BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppppxtBIND - BioGRID pt PAI2 (1) PAI2sq~pppsq~uq~ sq~%th HPRD t!Wilczynska M et al. (2003) EMBO Jtin vivotHPRD pppppppppxtHPRD pt DCP2 (1) PSB1sq~;(pppsq~uq~ sq~kY:t IntAct BioGRID BIND HPRD t!Lehner B et al. (2004) Genome Rest two hybridtBIND - HPRD - IntAct - BioGRID pppppppppxtBIND - HPRD - IntAct - BioGRID pt RERE (3) ATN1sq~cDpppsq~uq~ sq~aYt IntAct MINT tLim J et al. (2006) Cellt two hybridtIntAct - MINT sq~%0t BioGRID HPRD t(Yanagisawa H et al. (2000) Hum Mol Genettin vivotHPRD - BioGRID sq~%0t BioGRID HPRD t(Yanagisawa H et al. (2000) Hum Mol Genettin vitrotHPRD - BioGRID pppppppxtHPRD - IntAct - MINT - BioGRID ptCIAO1 (1) HSPB1sq~MwE%pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA2 (4) PSB4sq~Qpppsq~uq~ sq~>P% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID sq~kTunts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct sq~9untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT ppppppxtIntAct - MINT - BioGRID pt PSB10 (1) PTNsq~Epppsq~uq~ sq~nʪt IntAct HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct pppppppppxtHPRD - IntAct pt PSA2 (4) PSB7sq~#pppsq~uq~ sq~'unts IntAct t,Claverol S et al. (2002) Mol Cell Proteomicst"affinity chromatography technologytIntAct sq~>P'% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P'% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID sq~kT'unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct ppppppxtIntAct - BioGRID pt VINC (1) RSMBsq~@V06pppsq~uq~ sq~`%tm BIND tde Hoog CL et al. (2004) Celltmolecular interactiontBIND pppppppppxtBIND ptKIF3C (1) KIF3Csq~d0d0pppsq~uq~ sq~5Yth HPRD t"Yang Z et al. (1998) Mol Biol Cellt two hybridtHPRD pppppppppxtHPRD ptSTX11 (1) PRS6Asq~Kn{pppsq~uq~ sq~n*ʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT pt P80C (6) P80Csq~DDpppsq~uq~ sq~i3%%0t BioGRID HPRD t%Hebert MD et al. (2000) Mol Biol Celltin vitrotHPRD - BioGRID sq~i3%%0t BioGRID HPRD t%Hebert MD et al. (2000) Mol Biol Celltin vivotHPRD - BioGRID sq~i3%Y0t BioGRID HPRD t%Hebert MD et al. (2000) Mol Biol Cellt two hybridtHPRD - BioGRID sq~a%yt IntAct MINT tLim J et al. (2006) Cellttwo hybrid arraytIntAct - MINT sq~a%Yt IntAct MINT tLim J et al. (2006) Cellt two hybridtIntAct - MINT sq~J%3 tc BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppxtHPRD - IntAct - MINT - BioGRID ptIKKE (1) PRS6Bsq~PI pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPRKN2 (3) PSA7sq~1Tpppsq~uq~ sq~$ʪtn MINT t%Dächsel JC et al. (2005) FEBS Lettttwo hybrid pooling approachtMINT sq~$untn MINT t%Dächsel JC et al. (2005) FEBS Letttanti tag coimmunoprecipitationtMINT sq~$untn MINT t%Dächsel JC et al. (2005) FEBS Letttanti bait coimmunoprecipitationtMINT pppppppxtMINT ptRIPK2 (1) PSA7sq~Lpppsq~uq~ sq~ounts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptRIPK2 (1) PSA6sq~Lpppsq~uq~ sq~Z$unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSA1 (1) T22D4sq~0pppsq~uq~ sq~Jʪ6t IntAct MINT BioGRID HPRD tRual JF et al. (2005) Naturettwo hybrid pooling approachtHPRD - IntAct - MINT - BioGRID pppppppppxtHPRD - IntAct - MINT - BioGRID pt PSB2 (1) PSB1sq~(pppsq~uq~ sq~w0<Yth HPRD t5Kristensen P et al. (1994) Biochem Biophys Res Communt two hybridtHPRD pppppppppxtHPRD pt ATG5 (1) PSA3sq~tpppsq~uq~ sq~sunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt NEP1 (1) PSB7sq~#pppsq~uq~ sq~nSʪt IntAct HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct pppppppppxtHPRD - IntAct pt ATG5 (1) PSA2sq~tpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt ATG5 (1) PSA1sq~tpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA2 (4) PSA6sq~pppsq~uq~ sq~S$?k,ts IntAct t!Apcher GS et al. (2004) FEBS Letttcosedimentation in solutiontIntAct sq~>P?k% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P?k% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID sq~r?kYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct ppppppxtIntAct - BioGRID pt PRS4 (1) DIPAsq~M0Opppsq~uq~ sq~JHʪ6t IntAct MINT BioGRID HPRD tRual JF et al. (2005) Naturettwo hybrid pooling approachtHPRD - IntAct - MINT - BioGRID pppppppppxtHPRD - IntAct - MINT - BioGRID pt ATG5 (1) PSA7sq~tpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt IKKE (1) PSA2sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptEIF1B (1) UCHL5sq~P~pppsq~uq~ sq~Vunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt 41 (1) PSA1sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPRKN2 (2) PRKN2sq~1T1Tpppsq~uq~ sq~Yth HPRD t!Staropoli JF et al. (2003) Neuront two hybridtHPRD sq~%th HPRD t!Staropoli JF et al. (2003) Neurontin vivotHPRD ppppppppxtHPRD pt IKKE (1) PSA7sq~Ppppsq~uq~ sq~un"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt LEU1 (1) PSA1sq~_pppsq~uq~ sq~n ʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT pt IKKE (1) PSA6sq~Ppppsq~uq~ sq~Munts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptEGR1 (2) CSK21sq~dpppsq~uq~ sq~.Yth HPRD t Jain N et al. (1996) J Biol Chemt two hybridtHPRD sq~.%th HPRD t Jain N et al. (1996) J Biol Chemtin vivotHPRD ppppppppxtHPRD pt 41 (1) PSA6sq~Ppppsq~uq~ sq~lunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptRIOK3 (1) PSB1sq~P(pppsq~uq~ sq~Kun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptFANCG (4) FANCGsq~pppsq~uq~ sq~7 Y tc BioGRID t1Huber PA et al. (2000) Biochem Biophys Res Communt two hybridtBioGRID sq~A- Y tc BioGRID t'Medhurst AL et al. (2001) Hum Mol Genett two hybridtBioGRID sq~ % tc BioGRID t!Park SJ et al. (2004) J Biol ChemtcopurificationtBioGRID sq~J 3 tc BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppxtBioGRID pt IKKE (1) PSA1sq~Ppppsq~uq~ sq~$unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA7 (1) PLK1sq~Epppsq~uq~ sq~o %0t BioGRID HPRD t'Feng Y et al. (2001) Cell Growth Differtin vivotHPRD - BioGRID pppppppppxtHPRD - BioGRID pt 41 (1) PSA7sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt TFE3 (1) PSA1sq~Q9pppsq~uq~ sq~Yunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt DCP2 (1) DCP2sq~;;pppsq~uq~ sq~k_%th HPRD t!Lehner B et al. (2004) Genome Restin vitrotHPRD pppppppppxtHPRD pt PSA1 (1) PSB4sq~Qpppsq~uq~ sq~w0=Yth HPRD t5Kristensen P et al. (1994) Biochem Biophys Res Communt two hybridtHPRD pppppppppxtHPRD pt TFE3 (1) PSA3sq~Q9pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptNDKB (1) PSD12sq~Qtpppsq~uq~ sq~Punts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSMD4 (1) PSMD4sq~//pppsq~uq~ sq~BP$buntn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT pt PSB6 (1) POMPsq~&"pppsq~uq~ sq~r?xYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct pt PSB7 (2) PSA3sq~#pppsq~uq~ sq~T^unts IntAct t,Claverol S et al. (2002) Mol Cell Proteomicst"affinity chromatography technologytIntAct sq~9T^untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT ppppppppxtIntAct - MINT pt TFE3 (1) PSA6sq~Q9pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSB1 (1) PSB7sq~(#pppsq~uq~ sq~r?Yts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct ptPSMD4 (1) PSMD1sq~/Dpppsq~uq~ sq~BP$_untn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT ptTRAF6 (2) PSD12sq~Ttpppsq~uq~ sq~37t IntAct MINT DIP BioGRID HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationt%DIP - HPRD - IntAct - MINT - BioGRID sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct ppppppppxt%DIP - HPRD - IntAct - MINT - BioGRID ptPSMD4 (1) PSMD3sq~/spppsq~uq~ sq~BP$auntn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT pt PSB1 (1) PSB5sq~('pppsq~uq~ sq~r?Yts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct ptHS90B (1) PSMD1sq~Dpppsq~uq~ sq~'untn MINT t"Falsone SF et al. (2005) FEBS Letttanti bait coimmunoprecipitationtMINT pppppppppxtMINT ptTRAF6 (2) PSD13sq~Ttpppsq~uq~ sq~37t IntAct MINT DIP BioGRID HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationt%DIP - HPRD - IntAct - MINT - BioGRID sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct ppppppppxt%DIP - HPRD - IntAct - MINT - BioGRID pt PSB1 (1) PSB6sq~(&pppsq~uq~ sq~w0;Yth HPRD t5Kristensen P et al. (1994) Biochem Biophys Res Communt two hybridtHPRD pppppppppxtHPRD ptCIAO1 (1) PSB1sq~Mw(pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt IKKE (1) PSB4sq~PQpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt ILK (1) PSB1sq~f(pppsq~uq~ sq~WZunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt IKKE (1) PSB3sq~P%pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt IKKE (1) PSB6sq~P&pppsq~uq~ sq~Hunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptTRAF6 (2) PSMD6sq~TQpppsq~uq~ sq~V3t IntAct MINT DIP HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtDIP - HPRD - IntAct - MINT sq~Vunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct ppppppppxtDIP - HPRD - IntAct - MINT ptIKBE (1) HS90Bsq~pppsq~uq~ sq~3ts IntAct t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct pppppppppxtIntAct pt 3MG (1) 3MGsq~PPpppsq~uq~ sq~[unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSMD6 (1) PSA1sq~Qpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA4 (1) CO2sq~pppsq~uq~ sq~|U|%0t BioGRID HPRD t#Arribas J et al. (1994) J Biol Chemtin vitrotHPRD - BioGRID pppppppppxtHPRD - BioGRID ptPSMD6 (1) PSA3sq~Qpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt VINC (2) VINCsq~@V@Vpppsq~uq~ sq~X4 U%tm BIND tIzard T et al. (2004) Naturetmolecular interactiontBIND sq~J U3 tl BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppppxtBIND - BioGRID ptPSMD6 (1) PSA2sq~Qpppsq~uq~ sq~un"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt IKKE (1) PSB1sq~P(pppsq~uq~ sq~[unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSMD6 (1) PRS6Bsq~QI pppsq~uq~ sq~Wun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptPSMD6 (1) PRS6Asq~Q{pppsq~uq~ sq~Xun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt NMI (1) NMIsq~VVpppsq~uq~ sq~֦%t BIND HPRD tLi H et al. (2002) J Biol Chemtmolecular interactiont BIND - HPRD pppppppppxt BIND - HPRD ptSMAD1 (2) STUB1sq~pppsq~uq~ sq~ %tm BIND t'Barrios-Rodiles M et al. (2005) Sciencetmolecular interactiontBIND sq~U %t BIND HPRD t1Li RF et al. (2005) Colloids Surf B Biointerfacestmolecular interactiont BIND - HPRD ppppppppxt BIND - HPRD ptGRP78 (1) PSA2sq~pppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptCSK21 (1) CDN1Asq~d>pppsq~uq~ sq~%th HPRD t+Romero-Oliva F et al. (2001) J Cell Biochemtin vivotHPRD pppppppppxtHPRD ptSOMA (1) PSMD3sq~Sspppsq~uq~ sq~-unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt VHL (1) VHLsq~AApppsq~uq~ sq~&`%ts IntAct tBaek JH et al. (2005) Mol Cellt pull downtIntAct pppppppppxtIntAct ptIKKE (1) PSMD6sq~PQpppsq~uq~ sq~hunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptIKKE (1) PSMD3sq~Pspppsq~uq~ sq~]unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt VINC (2) VIMEsq~@VEpppsq~uq~ sq~` w%tm BIND tde Hoog CL et al. (2004) Celltmolecular interactiontBIND sq~J w3 tl BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppppxtBIND - BioGRID ptPSMD6 (1) PSB7sq~Q#pppsq~uq~ sq~\unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPRS6A (2) PRS6Asq~{{pppsq~uq~ sq~%0t BioGRID HPRD t'Ishizuka T et al. (2001) Mol Endocrinoltin vivotHPRD - BioGRID sq~%0t BioGRID HPRD t'Ishizuka T et al. (2001) Mol Endocrinoltin vitrotHPRD - BioGRID ppppppppxtHPRD - BioGRID ptIKKE (1) PSMD1sq~PDpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptGBRL2 (1) PSA1sq~Dpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt MAX (2) CSK21sq~E"dpppsq~uq~ sq~%th HPRD t.Krippner-Heidenreich A et al. (2001) Biochem Jtin vivotHPRD sq~Yth HPRD t.Krippner-Heidenreich A et al. (2001) Biochem Jt two hybridtHPRD ppppppppxtHPRD ptCASP4 (1) PSB1sq~Q](pppsq~uq~ sq~Wun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptQ53X72 (1) PSA1sq~pppsq~uq~ sq~JYtn MINT tRual JF et al. (2005) Naturet two hybridtMINT pppppppppxtMINT ptGBRL2 (1) PSA7sq~Dpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSA7 (2) HIF1Asq~pppsq~uq~ sq~ `%4tB MINT BioGRID HPRD tCho S et al. (2001) FEBS Lettt pull downtHPRD - MINT - BioGRID sq~ un4tB MINT BioGRID HPRD tCho S et al. (2001) FEBS LetttcoimmunoprecipitationtHPRD - MINT - BioGRID ppppppppxtHPRD - MINT - BioGRID ptPSMD4 (1) STUB1sq~/pppsq~uq~ sq~k%th HPRD t%Connell P et al. (2001) Nat Cell Bioltin vivotHPRD pppppppppxtHPRD pt PASK (1) PSB1sq~t(pppsq~uq~ sq~ZYun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptPRS6B (1) PRS4sq~I Mpppsq~uq~ sq~un"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptCK049 (1) PSA1sq~LHpppsq~uq~ sq~nƛʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT pt1433Z (1) CRYABsq~Upppsq~uq~ sq~Sunts IntAct t$Cottrell BA et al. (2005) Ann Neuroltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptESR1 (1) HS90Bsq~pppsq~uq~ sq~ %t MINT HPRD t:Bouhouche-Chatelier L et al. (2001) Cell Stress Chaperonestcross-linking studyt HPRD - MINT pppppppppxt HPRD - MINT ptPSB4 (1) PSMD1sq~QDpppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptPSA5 (1) NDUS1sq~Js%pppsq~uq~ sq~2S23ts IntAct t Koch HB et al. (2007) Cell Cyclettandem affinity purificationtIntAct pppppppppxtIntAct ptPSA1 (1) UBE3Asq~pppsq~uq~ sq~3Yth HPRD t"Kleijnen MF et al. (2000) Mol Cellt two hybridtHPRD pppppppppxtHPRD pt SOMA (1) PSB3sq~S%pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt RERE (1) BAT2sq~cDpppsq~uq~ sq~aYtI IntAct MINT HPRD tLim J et al. 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(2004) Nat Cell Biolttandem affinity purificationt%DIP - HPRD - IntAct - MINT - BioGRID pppppppppxt%DIP - HPRD - IntAct - MINT - BioGRID pt PAK2 (3) PAK2sq~DDpppsq~uq~ sq~5s%th HPRD t!Gatti A et al. (1999) J Biol Chemtin vivotHPRD sq~s%ts IntAct t&Pirruccello M et al. (2006) J Mol Bioltprotein kinase assaytIntAct sq~Rs%tm BIND t Swingler S et al. (1997) J Viroltmolecular interactiontBIND pppppppxtBIND - HPRD - IntAct pt PSA6 (2) PLK1sq~Epppsq~uq~ sq~o %0t BioGRID HPRD t'Feng Y et al. (2001) Cell Growth Differtin vivotHPRD - BioGRID sq~J 3 tc BioGRID tRual JF et al. (2005) Naturettandem affinity purificationtBioGRID ppppppppxtHPRD - BioGRID pt PSB5 (1) SYACsq~'Dpppsq~uq~ sq~'unts IntAct t"Falsone SF et al. (2005) FEBS Letttanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptSTX11 (1) STX11sq~KnKnpppsq~uq~ sq~J ʪ6t IntAct MINT BioGRID HPRD tRual JF et al. 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(2002) EMBO Jtin vitrotBioGRID pppxt&BIND - HPRD - IntAct - MINT - BioGRID pt 41 (1) PSB7sq~P#pppsq~uq~ sq~9unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PASK (2) PASKsq~ttpppsq~uq~ sq~Vunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct sq~fV%th HPRD t/Rutter J et al. (2001) Proc Natl Acad Sci U S Atin vivotHPRD ppppppppxtHPRD - IntAct pt 41 (1) PSB1sq~P(pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptQ6IBU1 (1) PSB1sq~P(pppsq~uq~ sq~Xdunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PRIO (1) PSA3sq~pppsq~uq~ sq~aYtI IntAct MINT HPRD tLim J et al. (2006) Cellt two hybridtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT pt 41 (1) PSB3sq~P%pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt IKBE (1) PSA5sq~Jpppsq~uq~ sq~w3ts IntAct t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct pppppppppxtIntAct ptPSA3 (1) STUB1sq~pppsq~uq~ sq~lYth HPRD t%Connell P et al. (2001) Nat Cell Biolt two hybridtHPRD pppppppppxtHPRD pt ILK (1) HSPB1sq~fE%pppsq~uq~ sq~Yun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptPSB4 (1) PRS6Asq~Q{pppsq~uq~ sq~2R3ts IntAct t Koch HB et al. (2007) Cell Cyclettandem affinity purificationtIntAct pppppppppxtIntAct ptRRMJ1 (1) PSA3sq~t,pppsq~uq~ sq~=unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt TNIK (1) PRS4sq~d Mpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptNCOA3 (2) GRIP1sq~h{pppsq~uq~ sq~ untn MINT tZhang Y et al. 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(2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSB5 (1) PLK1sq~'Epppsq~uq~ sq~o%0t BioGRID HPRD t'Feng Y et al. (2001) Cell Growth Differtin vivotHPRD - BioGRID pppppppppxtHPRD - BioGRID pt 1B42 (1) PSA1sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptTRAF6 (1) PSB4sq~TQpppsq~uq~ sq~Vunts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt BAT2 (1) PSA3sq~Dpppsq~uq~ sq~+Y>t IntAct MINT BioGRID BIND HPRD tLehner B et al. (2004) Genomicst two hybridt&BIND - HPRD - IntAct - MINT - BioGRID pppppppppxt&BIND - HPRD - IntAct - MINT - BioGRID ptTRAF6 (1) PSB3sq~T%pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptTRAF6 (1) PSB2sq~Tpppsq~uq~ sq~3t IntAct MINT t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct - MINT pppppppppxtIntAct - MINT pt PSB1 (2) PSB3sq~(%pppsq~uq~ sq~kT?unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct sq~r?Yts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct ppppppppxtIntAct pt PSA7 (2) PSB7sq~#pppsq~uq~ sq~%untn MINT t%Dächsel JC et al. (2005) FEBS Letttanti bait coimmunoprecipitationtMINT sq~w0%Yth HPRD t5Kristensen P et al. (1994) Biochem Biophys Res Communt two hybridtHPRD ppppppppxt HPRD - MINT ptCSK21 (1) CSK21sq~ddpppsq~uq~ sq~!s Yth HPRD t'Belenguer P et al. (1990) Mol Cell Biolt two hybridtHPRD pppppppppxtHPRD ptTRAF6 (1) PSB6sq~T&pppsq~uq~ sq~3t IntAct MINT t)Bouwmeester T et al. (2004) Nat Cell Biolttandem affinity purificationtIntAct - MINT pppppppppxtIntAct - MINT pt PSB2 (2) PSB5sq~'pppsq~uq~ sq~kT?~unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct sq~r?~Yts IntAct t3Jayarapu K et al. 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(1998) Bloodt two hybridtHPRD sq~D&%th HPRD t Calverley DC et al. (1998) Bloodtin vivotHPRD sq~&untn MINT tGu YM et al. (2006) FEBS Letttanti tag coimmunoprecipitationtMINT sq~&%(t BioGRID BIND tObsil T et al. (2001) Celltin vitrotBIND - BioGRID sq~>_&%tl BIND t%Powell DW et al. (2003) Mol Cell Bioltmolecular interactiontBIND sq~ &%tl BIND t"Rittinger K et al. (1999) Mol Celltmolecular interactiontBIND ppppxtBIND - HPRD - MINT - BioGRID ptSMAD1 (1) PSMD1sq~Dpppsq~uq~ sq~kYtC MINT BIND HPRD t"Colland F et al. (2004) Genome Rest two hybridtBIND - HPRD - MINT pppppppppxtBIND - HPRD - MINT ptPSA7 (1) PRS6Bsq~I pppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptPSMD4 (1) PRS4sq~/Mpppsq~uq~ sq~BP$Runtn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT pt ATG5 (1) PRS4sq~tMpppsq~uq~ sq~unts IntAct t$Ewing RM et al. 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(2004) Acta Biochim Biophys Sin (Shanghai)tin vivotHPRD sq~Js%th HPRD t7Fan J et al. (2004) Acta Biochim Biophys Sin (Shanghai)tin vitrotHPRD ppppppppxtHPRD pt1C04 (1) PSMD6sq~tjQpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSB3 (2) PSB4sq~%Qpppsq~uq~ sq~2R3ts IntAct t Koch HB et al. (2007) Cell Cyclettandem affinity purificationtIntAct sq~w0RYth HPRD t5Kristensen P et al. (1994) Biochem Biophys Res Communt two hybridtHPRD ppppppppxtHPRD - IntAct pt PSA3 (2) PSB5sq~'pppsq~uq~ sq~?|unts IntAct t,Claverol S et al. (2002) Mol Cell Proteomicst"affinity chromatography technologytIntAct sq~r?|Yts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct ppppppppxtIntAct ptEIF1B (1) PSA2sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptEIF1B (1) PSA7sq~Ppppsq~uq~ sq~[unts IntAct t$Ewing RM et al. 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(1994) Biochem Biophys Res Communt two hybridtHPRD pppppppppxtHPRD pt PSA2 (2) GDITsq~{pppsq~uq~ sq~>P]% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>P]% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID ppppppppxtBioGRID pt VHL (1) PSB5sq~A'pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSB9 (3) GRIP1sq~){pppsq~uq~ sq~RP`%tn MINT tZhang H et al. (2006) EMBO Jt pull downtMINT sq~RPYtn MINT tZhang H et al. (2006) EMBO Jt two hybridtMINT sq~RPuntn MINT tZhang H et al. (2006) EMBO Jtanti bait coimmunoprecipitationtMINT pppppppxtMINT ptPSD13 (3) PSD12sq~ttpppsq~uq~ sq~IYth HPRD t)Bouwmeester T et al. (2004) Nat Cell Biolt two hybridtHPRD sq~I3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID sq~7IYth HPRD t!Gandhi TK et al. (2006) Nat Genett two hybridtHPRD pppppppxtHPRD - BioGRID pt VHL (1) PSB3sq~A%pppsq~uq~ sq~WQun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID pt VHL (1) PSB1sq~A(pppsq~uq~ sq~Eun"t IntAct BioGRID t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct - BioGRID pppppppppxtIntAct - BioGRID ptPSB10 (1) PSA5sq~Jpppsq~uq~ sq~kT'unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptCSK21 (1) HIF1Asq~dpppsq~uq~ sq~ ; }%t MINT HPRD tCho H et al. (2007) FEBS Letttprotein kinase assayt HPRD - MINT pppppppppxt HPRD - MINT ptRRMJ1 (1) FBRLsq~t,&pppsq~uq~ sq~|.%th HPRD t%Pintard L et al. (2000) Mol Cell Bioltin vivotHPRD pppppppppxtHPRD pt PSA1 (1) VIMEsq~Epppsq~uq~ sq~Jʪ2t> IntAct BioGRID HPRD tRual JF et al. 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(2004) FEBS Lettt two hybridtHPRD - IntAct - MINT sq~S$?i`%tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt pull downtHPRD - IntAct - MINT sq~r?iYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct sq~9?iuntn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppxtHPRD - IntAct - MINT pt RUXF (1) PSA3sq~A3pppsq~uq~ sq~n.ʪtI IntAct MINT HPRD tStelzl U et al. (2005) Cellttwo hybrid pooling approachtHPRD - IntAct - MINT pppppppppxtHPRD - IntAct - MINT ptHUNIN (1) HUNINsq~pppsq~uq~ sq~%th HPRD t%Terashita K et al. (2003) J Neurochemtin vivotHPRD pppppppppxtHPRD pt CRCM (1) PSA1sq~&gpppsq~uq~ sq~Y unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PTN (3) PTNsq~EEpppsq~uq~ sq~Iu%th HPRD t:Bernard-Pierrot I et al. (1999) Biochem Biophys Res Communtin vivotHPRD sq~Iu%th HPRD t:Bernard-Pierrot I et al. 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(1999) Proc Natl Acad Sci U S Atin vitrotBioGRID sq~% tc BioGRID t1Jelesko JG et al. (1999) Proc Natl Acad Sci U S Atin vivotBioGRID sq~>q% tc BioGRID t"Kruyt FA et al. (1999) J Biol Chemt western blottBioGRID sq~>' tc BioGRID t"Kruyt FA et al. (1999) J Biol ChemtReconstituted ComplextBioGRID sq~Cq% tc BioGRID tKuang Y et al. (2000) Bloodt western blottBioGRID sq~CY tc BioGRID tKuang Y et al. (2000) Bloodt two hybridtBioGRID sq~A-Y$t MINT BioGRID t'Medhurst AL et al. (2001) Hum Mol Genett two hybridtMINT - BioGRID sq~'3 tc BioGRID t!Meetei AR et al. (2003) Nat Genetttandem affinity purificationtBioGRID sq~q% tc BioGRID t!Park SJ et al. (2004) J Biol Chemt western blottBioGRID sq~% tc BioGRID t!Park SJ et al. (2004) J Biol ChemtcopurificationtBioGRID sq~)Y$t MINT BioGRID tReuter T et al. (2000) Bloodt two hybridtMINT - BioGRID sq~Jʪ&tD IntAct MINT BioGRID tRual JF et al. (2005) Naturettwo hybrid pooling approachtIntAct - MINT - BioGRID sq~4Yth HPRD tTaniguchi T et al. 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(2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT pt ATN1 (3) ATN1sq~DDpppsq~uq~ sq~aɍYt IntAct MINT tLim J et al. (2006) Cellt two hybridtIntAct - MINT sq~6Mɍ%th HPRD t'Wood JD et al. (1998) Mol Cell Neuroscitin vivotHPRD sq~6Mɍ%th HPRD t'Wood JD et al. (1998) Mol Cell Neuroscitin vitrotHPRD pppppppxtHPRD - IntAct - MINT ptPSMD4 (1) PSA3sq~/pppsq~uq~ sq~BP$Yuntn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT pt 1B42 (1) PRS4sq~PMpppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPSMD4 (1) PSA5sq~/Jpppsq~uq~ sq~BP$Zuntn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT ptPSMD4 (1) PSA6sq~/pppsq~uq~ sq~BP$[untn MINT tHamazaki J et al. (2006) EMBO Jtanti tag coimmunoprecipitationtMINT pppppppppxtMINT ptPSMD4 (1) PSA7sq~/pppsq~uq~ sq~BP$\untn MINT tHamazaki J et al. 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(2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSB3 (3) PSA2sq~%pppsq~uq~ sq~T]unts IntAct t,Claverol S et al. (2002) Mol Cell Proteomicst"affinity chromatography technologytIntAct sq~>PT]% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vivotBioGRID sq~>PT]% tc BioGRID t'Elenich LA et al. (1999) Immunogeneticstin vitrotBioGRID pppppppxtIntAct - BioGRID pt LSM1 (1) PSB8sq~@pppsq~uq~ sq~kY:t IntAct BioGRID BIND HPRD t!Lehner B et al. (2004) Genome Rest two hybridtBIND - HPRD - IntAct - BioGRID pppppppppxtBIND - HPRD - IntAct - BioGRID pt 1C04 (1) PSA2sq~tjpppsq~uq~ sq~Munts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA7 (4) PSA1sq~pppsq~uq~ sq~S$?j,tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Letttcosedimentation in solutiontHPRD - IntAct - MINT sq~S$?jYtI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt two hybridtHPRD - IntAct - MINT sq~S$?j`%tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt pull downtHPRD - IntAct - MINT sq~r?jYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct ppppppxtHPRD - IntAct - MINT ptPSD13 (1) PSD11sq~tspppsq~uq~ sq~I3 tc BioGRID t$Ewing RM et al. (2007) Mol Syst Biolttandem affinity purificationtBioGRID pppppppppxtBioGRID pt PSB5 (1) POMPsq~'"pppsq~uq~ sq~r?zYts IntAct t3Jayarapu K et al. (2004) Biochem Biophys Res Communt two hybridtIntAct pppppppppxtIntAct pt LSM1 (1) PSB5sq~'pppsq~uq~ sq~kY:t IntAct BioGRID BIND HPRD t!Lehner B et al. (2004) Genome Rest two hybridtBIND - HPRD - IntAct - BioGRID pppppppppxtBIND - HPRD - IntAct - BioGRID pt PSA7 (4) PSA3sq~pppsq~uq~ sq~S$ܑ,tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Letttcosedimentation in solutiontHPRD - IntAct - MINT sq~S$ܑYtI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt two hybridtHPRD - IntAct - MINT sq~S$ܑ`%tI IntAct MINT HPRD t!Apcher GS et al. (2004) FEBS Lettt pull downtHPRD - IntAct - MINT sq~2ܑ3ts IntAct t Koch HB et al. (2007) Cell Cyclettandem affinity purificationtIntAct ppppppxtHPRD - IntAct - MINT ptPSA3 (1) PSB10sq~pppsq~uq~ sq~kT'unts IntAct t"Froment C et al. (2005) Proteomicstanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptAAKB1 (1) PSB3sq~P%pppsq~uq~ sq~ unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSB6 (1) FBRLsq~&&pppsq~uq~ sq~ M%0t BioGRID HPRD t"Chen M et al. (2002) Mol Biol Celltin vitrotHPRD - BioGRID pppppppppxtHPRD - BioGRID pt VIME (1) NDKBsq~EQpppsq~uq~ sq~+Y%0t BioGRID HPRD t$Roymans D et al. (2000) Exp Cell Restin vivotHPRD - BioGRID pppppppppxtHPRD - BioGRID ptESR1 (1) UBE3Asq~pppsq~uq~ sq~{-%ta DIP t#Nawaz Z et al. (1999) Mol Cell Biolt"experimental interaction detectiontDIP pppppppppxtDIP ptAAKB1 (1) PRS6Asq~P{pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptAAKB1 (1) PRS6Bsq~PI pppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pt PSA5 (2) CCR5sq~J&upppsq~uq~ sq~ HPRD t&Fernandis AZ et al. (2002) J Biol Chemt two hybridtHPRD sq~ HPRD t&Fernandis AZ et al. (2002) J Biol Chemtin vitrotHPRD ppppppppxtHPRD ptCRYAB (1) CRYABsq~UUpppsq~uq~ sq~g%th HPRD tFu L et al. (2002) J Biol Chemtin vivotHPRD pppppppppxtHPRD pt 3MG (1) PSA1sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct ptPRS6A (1) PSB1sq~{(pppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT ptPSB2 (1) UCHL5sq~~pppsq~uq~ sq~96untn MINT tQiu XB et al. (2006) EMBO Jt"affinity chromatography technologytMINT pppppppppxtMINT pt 3MG (1) PSA2sq~Ppppsq~uq~ sq~unts IntAct t$Ewing RM et al. (2007) Mol Syst Bioltanti bait coimmunoprecipitationtIntAct pppppppppxtIntAct pxxsq~?@ wq~ sq~?@wtQ96DE8srdatabasemapping.ProteinuWSRD clustercoefI connectcoefIidInumintItaxonIdL descriptionq~Lensq~Lgensq~LgoStatsq~Lgosq~Linterq~Lpfamsq~LswissIdq~L swissNameq~Lsynonimsq~L taxonNameq~xp+%tPSMD14 proteinsq~uq~ srdatabasemapping.UniEnQW)UIidLensIdq~xp+tENSG00000115233pppppppppxpsq~uq~ srdatabasemapping.GoStat>IgoIdZknowInumI proteinIdIrootL descriptionq~xp+tF:protein bindingsq~Z+t&C:proteasome complex (sensu Eukaryota)sq~Z+t0C:proteasome regulatory particle (sensu Eukar...pppppppxppptQ96DE8t Q96DE8_HUMANpt Homo sapienstLEU1sq~P?<"g5_%tLeukemia-associated protein 1sq~uq~ sq~U_tENSG00000176124pppppppppxsq~uq~ srdatabasemapping.UniGennGs+wIidCtypeLgenIdq~xp_tDLEU1sq~m_tLEU1ppppppppxsq~Luq~ Psq~Z_tP:translational elongationsq~Z>_tP:protein tetramerizationsq~Z_t P:cell agingsq~Z|_tP:female gamete generationsq~Zk_t&P:multicellular organismal developmentsq~Z _t0P:transforming growth factor beta receptor si...sq~Z_tP:chromosome segregationsq~Z_tP:cell cycle arrestsq~ZG_tP:ER overload responsesq~Z_tP:cell motilitysq~Z_t P:transportsq~Z_tP:L-serine metabolic processsq~Z_tP:glycine metabolic processsq~Z_tP:protein localizationsq~Z [_tP:cell proliferationsq~ZǙ_t*P:negative regulation of helicase activitysq~Z6_t0P:regulation of mitochondrial membrane permea...sq~Z_t0P:DNA damage response, signal transduction by...sq~Z_t+P:natural killer cell mediated cytotoxicitysq~Z_t)P:cellular response to glucose starvationsq~Zw9_t%P:androgen receptor signaling pathwaysq~Zvd_t$P:negative regulation of cell growthsq~Zu_t0P:negative regulation of Wnt receptor signali...sq~Z@_tP:histone acetylationsq~Z@a_t&P:negative regulation of transcriptionsq~Z&_tP:organ morphogenesissq~Z!_t%P:caspase activation via cytochrome csq~Z_t/P:transcription from RNA polymerase II promotersq~Z_t,P:regulation of transcription, DNA-dependentsq~Z_tP:double-strand break repairsq~Z_tP:nucleotide-excision repairsq~Z_tP:base-excision repairsq~ZE_t0P:positive regulation of transcription, DNA-d...sq~Z_tF:protein bindingsq~Z_t F:GTP bindingsq~Z_t(F:translation elongation factor activitysq~Z_t F:ATP bindingsq~ZT_tF:GTPase activitysq~Z_t F:RNA bindingsq~Z_t+F:glycine hydroxymethyltransferase activitysq~Z_tF:nuclease activitysq~Z0_tF:MHC class I protein bindingsq~Z_t0F:ATPase activity, coupled to transmembrane m...sq~Z_tF:copper ion bindingsq~Z_tF:DNA strand annealing activitysq~ZNJ_tF:unfolded protein bindingsq~Z_tF:androgen receptor bindingsq~Zg_tF:beta-tubulin bindingsq~Z_t%F:protein heterodimerization activitysq~Zt_tF:transcription factor activitysq~Z_tF:alpha-tubulin bindingsq~Z_t$F:transcription coactivator activitysq~ZM_tF:enzyme bindingsq~ZJ;_t F:GDP bindingsq~Z_tF:growth factor activitysq~Z_tF:transcription factor bindingsq~Z N_tF:zinc ion bindingsq~Z}_tF:protein N-terminus bindingsq~Zk_tC:mitochondrionsq~Z_t C:nucleussq~Z_t C:cytosolsq~Z_t0C:eukaryotic translation elongation factor 1 ...sq~Z!_tC:spindle midzonesq~Zi_t C:cytoplasmsq~Zb_t C:nucleolussq~Z_t&C:proteasome complex (sensu Eukaryota)sq~Z_t0C:ATP-binding cassette (ABC) transporter complexsq~Z?_tC:nuclear matrixsq~Z>_tC:integral to membranesq~Zw _t C:midbodysq~Z_tC:intracellularsq~Z_t(C:NuA4 histone acetyltransferase complexsq~Z_tC:insoluble fractionsq~Z_t C:polysomesq~Z_t C:nucleoplasmsq~Z_tC:cytoskeletonppppxsq~uq~ srdatabasemapping.UniGo2u|-IidIrootL descriptionq~LgoIdq~xp_tF:protein bindingt5515pppppppppxpptO43261t LEU1_HUMANsq~uq~ srdatabasemapping.UniSynonimSZ-I proteinIdL descriptionq~xp_t!Deleted in lymphocytic leukemia 1pppppppppxt Homo sapienst3MGsq~P?hh2#P$%tDNA-3-methyladenine glycosylasesq~uq~ sq~UPtENSG00000103152pppppppppxsq~uq~ sq~mPtMPGsq~mPtAAGsq~mPtANPGsq~mPtMID1ppppppxsq~^uq~ sq~ZPtP:signal transductionsq~ZPtP:nucleotide-excision repairsq~ZPtP:transcription, DNA-dependentsq~Z9PtP:protein foldingsq~ZxPt0P:positive regulation of transcription from R...sq~ZnPtP:vitamin metabolic processsq~ZPtP:lipid metabolic processsq~ZPtP:aspartate catabolic processsq~Z=PtP:protein complex assemblysq~Z Pt P:translationsq~ZPtP:mRNA processingsq~ZPt,P:regulation of transcription, DNA-dependentsq~ZPtP:nucleosome disassemblysq~ZPtP:nucleosome assemblysq~ZtPtP:DNA replicationsq~ZPt P:endocytosissq~ZPtP:nucleocytoplasmic transportsq~ZPt P:apoptosissq~Z:Pt"P:negative regulation of apoptosissq~ZPt%P:regulation of macrophage activationsq~Z`PtP:homeostatic processsq~Zw8Pt%P:estrogen receptor signaling pathwaysq~ZFPt(P:N-terminal peptidyl-lysine acetylationsq~Z#PtP:nucleotide metabolic processsq~ZǓPt0P:positive regulation of transcription factor...sq~Z [PtP:cell proliferationsq~ZPt&P:establishment of blood-nerve barriersq~ZPtP:nervous system developmentsq~ZPt0P:cell surface receptor linked signal transdu...sq~ZJPtP:response to unfolded proteinsq~ZPtP:cell motilitysq~ZPtP:caspase activationsq~ZPtP:response to hypoxiasq~ZPt$P:prostaglandin biosynthetic processsq~ZPt,P:negative regulation of histone acetylationsq~ZPtF:protein bindingsq~ZtPtF:transcription factor activitysq~ZPt#F:thyroid hormone receptor activitysq~ZPt$F:transcription corepressor activitysq~ZqPtF:single-stranded DNA bindingsq~ZPt$F:transcription coactivator activitysq~ZPt F:RNA bindingsq~Z PtF:3'-5' exonuclease activitysq~Z NPtF:zinc ion bindingsq~ZPt$F:structural constituent of ribosomesq~ZVPtF:protein C-terminus bindingsq~ZPtF:actin bindingsq~ZPt)F:acetyl-CoA C-acetyltransferase activitysq~Z!Pt0F:protein phosphatase type 2A regulator activitysq~Z!XPtF:Ran GTPase bindingsq~Z#_PtF:electron carrier activitysq~ZǏPtF:chaperone bindingsq~ZNJPtF:unfolded protein bindingsq~Z}PtF:protein N-terminus bindingsq~ZxPtF:steroid bindingsq~ZPtF:histone bindingsq~ZTPtF:GTPase activitysq~ZvLPtF:estrogen receptor activitysq~ZzPt0F:ligand-regulated transcription factor activitysq~Z Pt"F:glutathione transferase activitysq~Z2Pt$F:histone acetyltransferase activitysq~Z_PtF:transporter activitysq~ZQPt-F:extracellular matrix structural constituentsq~ZPtF:cytokine activitysq~ZPt%F:GDP-dissociation inhibitor activitysq~ZPtF:retinoid-X receptor activitysq~ZPt(F:protein phosphatase inhibitor activitysq~ZvPt*F:nitric-oxide synthase regulator activitysq~ZPtF:calcium ion bindingsq~Z Pt C:nucleussq~ZiPt C:cytoplasmsq~ZPt&C:proteasome complex (sensu Eukaryota)sq~ZkPtC:mitochondrionsq~ZPtC:mitochondrial matrixsq~ZPtC:paraspecklessq~ZPt0C:proteasome regulatory particle (sensu Eukar...sq~ZPt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZPt C:centrosomesq~ZPtC:late endosomesq~ZWPt!C:perinuclear region of cytoplasmsq~ZPt C:lysosomesq~ZPt C:polysomesq~ZPtC:integral to plasma membranesq~ZPtC:endoplasmic reticulumsq~Z bPt!C:F-actin capping protein complexsq~ZPtC:extracellular regionsq~ZPt$C:proteinaceous extracellular matrixsq~ZPtC:extracellular spacesq~Z'PtC:cell surfacesq~Z>Pt C:membranesq~Z>PtC:integral to membranesq~Z@PtC:chromatin remodeling complexsq~ZPtC:soluble fractionsq~ZyPt0C:mitochondrial proton-transporting ATP synth...ppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~PtP:base-excision repairt6284sq~PtP:DNA dealkylationt6307sq~PtF:damaged DNA bindingt3684sq~PtF:identical protein bindingt42802sq~Pt C:nucleoplasmt5654pppppxsq~uq~ srdatabasemapping.UniIntereIidLinterIdq~Lnameq~xpPt IPR003180tPurDNA_glycsylsepppppppppxsq~uq~ srdatabasemapping.UniPfamZ2ߝSIidLnameq~LpfamIdq~xpPt Pur_DNA_glycotPF02245pppppppppxtP29372t 3MG_HUMANsq~uq~ sq~Pt3-methyladenine DNA glycosidasesq~PtADPGsq~Pt3-alkyladenine DNA glycosylasesq~PtN-methylpurine-DNA glycosylaseppppppxt Homo sapienstPASKsq~Pt%t5PAS domain-containing serine/threonine-protein kinasesq~uq~ sq~UttENSG00000115687pppppppppxsq~uq~ sq~mttPASKsq~mttKIAA0135ppppppppxsq~uq~ sq~ZttP:rRNA processingsq~Z=ttP:protein complex assemblysq~ZDtt$P:protein amino acid phosphorylationsq~ZttF:protein bindingsq~Ztt F:RNA bindingsq~ZBtt*F:protein serine/threonine kinase activitysq~Ztt&C:proteasome complex (sensu Eukaryota)pppxsq~uq~ sq~ttF:identical protein bindingt42802pppppppppxsq~uq~ sq~tt IPR000014tPASsq~tt IPR013767tPAS_foldsq~tt IPR000719tProt_kinase_coresq~tt IPR008271tSer_thr_pkin_ASsq~tt IPR002290tSer_thr_pkinasepppppxsq~uq~ sq~ttPAStPF00989sq~ttPkinasetPF00069ppppppppxtQ96RG2t PASK_HUMANsq~uq~ sq~tt PAS-kinasesq~ttPASKINsq~tthPASKpppppppxt Homo sapienstCO2sq~P?ə%tComplement C2 precursorsq~uq~ sq~UtENSG00000166278sq~UtENSG00000204364sq~UtENSG00000206372pppppppxsq~uq~ sq~mtC2pppppppppxsq~ uq~ sq~Zt0P:G-protein coupled receptor protein signalin...sq~ZtP:activation of MAPK activitysq~Z,tP:complement activationsq~Z+tP:immune responsesq~Z*tP:inflammatory responsesq~Zt P:chemotaxissq~ZtF:receptor bindingsq~Zt$F:serine-type endopeptidase activitysq~ZItF:chemokine activitysq~ZtC:extracellular spacesq~Zt&C:proteasome complex (sensu Eukaryota)pppppppppxsq~uq~ sq~t*P:complement activation, classical pathwayt6958sq~tC:extracellular spacet5615ppppppppxsq~uq~ sq~t IPR011360t Compl_C2_Bsq~t IPR001254tPeptidase_S1_S6sq~t IPR001314t Peptidase_S1Asq~t IPR000436t Sushi_SCR_CCPsq~t IPR002035tVWF_Apppppxsq~uq~ sq~tSushitPF00084sq~tTrypsintPF00089sq~tVWAtPF00092pppppppxtP06681t CO2_HUMANsq~uq~ sq~tC3/C5 convertasesq~tComplement C2b fragmentsq~tComplement C2a fragmentpppppppxt Homo sapienstAURKBsq~P?Md6S!b"%t"Serine/threonine-protein kinase 12sq~uq~ sq~UbtENSG00000178999pppppppppxsq~uq~ sq~mbtAURKBsq~mbtAIK2sq~mbtAIM1sq~mbtARK2sq~mbtSTK12pppppxsq~uq~ sq~ZDbt$P:protein amino acid phosphorylationsq~ZKbtP:protein kinase cascadesq~Zbt P:cytokinesissq~ZbtP:signal transductionsq~ZFbt!P:peptidyl-serine phosphorylationsq~ZbtP:anti-apoptosissq~Z&>btP:embryonic developmentsq~Zbt(P:protein amino acid autophosphorylationsq~ZbtP:neuroblast proliferationsq~Zbt0P:cell surface receptor linked signal transdu...sq~ZbtP:signal complex assemblysq~Z bt0P:transforming growth factor beta receptor co...sq~ZsbtP:spermatogenesissq~Zbt0P:G-protein signaling, coupled to cGMP nucleo...sq~Zkbt&P:multicellular organismal developmentsq~Zxqbt-P:regulation of actin filament polymerizationsq~ZJbt!P:intracellular signaling cascadesq~ZbtP:meiotic recombinationsq~Zkbt0P:positive regulation of progression through ...sq~Zbt P:chemotaxissq~ZbtP:muscle contractionsq~Z&btP:response to stresssq~ZGbtP:ER overload responsesq~ZYbt0P:chromosome organization and biogenesis (sen...sq~Zbbt*P:cytoskeleton organization and biogenesissq~Zbt%P:spindle organization and biogenesissq~ZbtP:chromosome segregationsq~Zbt P:mitosissq~Zbt0P:mitotic cell cycle spindle assembly checkpointsq~Zbt'P:cytokinesis, initiation of separationsq~Zbt P:learningsq~ZbtP:feeding behaviorsq~Zbt)P:negative regulation of caspase activitysq~Zbt0P:positive regulation of gene-specific transc...sq~Zbt)P:negative regulation of neuron apoptosissq~ZbtP:regulation of transcriptionsq~Zbt'P:positive regulation of anti-apoptosissq~Zgbt*P:establishment of chromosome localizationsq~Zbt0P:positive regulation of protein export from ...sq~Zbt%P:phosphoinositide-mediated signalingsq~ZƤbt#P:T cell receptor signaling pathwaysq~Z4bt%P:regulation of RNA metabolic processsq~Z:bt"P:negative regulation of apoptosissq~Z9bt"P:positive regulation of apoptosissq~Zbt0P:Wnt receptor signaling pathway through beta...sq~ZPbt!P:regulation of heart contractionsq~Z \bt+P:positive regulation of cell proliferationsq~Z ^bt$P:insulin receptor signaling pathwaysq~Z btP:regulation of cell shapesq~Z'bt P:response to ionizing radiationsq~ZwbtP:tRNA methylationsq~Z{btP:protein complex localizationsq~Z{0bt*P:positive regulation of exit from mitosissq~Z{YbtP:spindle checkpointsq~Z{bt!P:regulation of protein stabilitysq~ZZbtP:protein heterotetramerizationsq~ZbtP:cell motilitysq~ZbtP:calcium ion transportsq~Zbt-P:negative regulation of cell-matrix adhesionsq~Zbt)P:cytokinesis, contractile ring formationsq~ZbtP:cell morphogenesissq~Z"btP:vasculogenesissq~Z-bt&P:epithelial to mesenchymal transitionsq~ZVbt'P:G2/M transition of mitotic cell cyclesq~ZJbt.P:regulation of progression through cell cyclesq~Zbt0P:regulation of transcription from RNA polyme...sq~Zbt P:DNA repairsq~Zbt0P:generation of precursor metabolites and energysq~Z@btP:protein modification processsq~ZFbt&P:protein amino acid dephosphorylationsq~ZYbtP:glycogen metabolic processsq~ZWbt P:carbohydrate metabolic processsq~Z btF:protein bindingsq~ZBbt*F:protein serine/threonine kinase activitysq~Zbt F:ATP bindingsq~ZbtF:SH2 domain bindingsq~Zkbt0F:non-membrane spanning protein tyrosine kina...sq~Z@btF:protein kinase activitysq~Z3bt#F:protein homodimerization activitysq~ZbtF:caspase inhibitor activitysq~Zbt$F:transcription corepressor activitysq~Z2btF:identical protein bindingsq~Zbt F:p53 bindingsq~ZbtF:alpha-tubulin bindingsq~ZbbtF:chromatin bindingsq~ZtbtF:transcription factor activitysq~ZUbt*F:cyclin-dependent protein kinase activitysq~Zbt#F:phosphoinositide 3-kinase bindingsq~Z'btF:insulin bindingsq~ZbtF:PTB domain bindingsq~Zbt%F:protein phosphatase type 1 activitysq~ZsbtF:NF-kappaB bindingsq~ZLbtF:GTPase bindingsq~ZbtF:magnesium ion bindingsq~ZgbtF:beta-tubulin bindingsq~ZbtF:cofactor bindingsq~Z}btF:protein N-terminus bindingsq~Zbt%F:protein heterodimerization activitysq~ZbtF:SMAD bindingsq~Zbt)F:transforming growth factor beta bindingsq~Z(bt$F:insulin receptor substrate bindingsq~ZXbt%F:glycogen synthase kinase 3 activitysq~ZdbtF:MAP kinase kinase activitysq~Z btF:MP kinase activitysq~Zbt0F:transmembrane receptor protein tyrosine kin...sq~ZbtF:SH3/SH2 adaptor activitysq~Z NbtF:zinc ion bindingsq~ZbtF:transcription factor bindingsq~ZQbtF:microtubule bindingsq~ZbtF:GTPase activator activitysq~ZbtF:Ras GTPase activator activitysq~ZbtF:receptor bindingsq~ZPbt(F:structural constituent of cytoskeletonsq~Zbt%F:receptor signaling protein activitysq~Zibt"F:protein-tyrosine kinase activitysq~ZMbt&F:potassium channel inhibitor activitysq~ZbtF:gamma-tubulin bindingsq~Zlbt0F:receptor signaling protein tyrosine kinase ...sq~Z@,bt/F:tRNA (cytosine-5-)-methyltransferase activitysq~Z?bt*F:1-phosphatidylinositol-3-kinase activitysq~ZbtF:insulin receptor activitysq~Zbt0F:transforming growth factor beta receptor ac...sq~Z bt C:nucleussq~Zibt C:cytoplasmsq~ZbtC:protein complexsq~Zbt C:spindlesq~ZbtC:spindle microtubulesq~ZbtC:integral to plasma membranesq~Zbt C:chromosome, pericentric regionsq~Zw bt C:midbodysq~Zbt&C:proteasome complex (sensu Eukaryota)sq~ZbtC:intermediate filamentsq~Zxbt"C:beta-catenin destruction complexsq~Zbt C:cytosolsq~Zbt C:centriolesq~Zbbt C:nucleolussq~ZYbtC:centric heterochromatinsq~ZbtC:cytoplasmic microtubulesq~Zy-bt*C:interphase microtubule organizing centerpppppppppppppppppppppxsq~uq~ sq~btF:protein bindingt5515pppppppppxsq~uq~ sq~bt IPR000719tProt_kinase_coresq~bt IPR008271tSer_thr_pkin_ASsq~bt IPR002290tSer_thr_pkinasepppppppxsq~uq~ sq~btPkinasetPF00069pppppppppxtQ96GD4t AURKB_HUMANsq~uq~ sq~btAurora-Bsq~bt1Aurora-and Ipl1-like midbody-associated protein 1sq~btAIM-1sq~btAurora/IPL1-related kinase 2sq~btAurora-related kinase 2sq~btSTK-1ppppxt Homo sapienstQ5JNW7sq~P?UUUUUX$%t5Proteasome (Prosome, macropain) subunit, beta type, 8sq~uq~ sq~U$tENSG00000204264sq~U$tENSG00000206234sq~U$tENSG00000206298pppppppxsq~uq~ sq~m$tPSMB8sq~m$tDAQB-69D7.6-004sq~m$tDASS-67H14.1-004sq~m$tXXbac-BCX32M13.6-004sq~m$tXXbac-BPG246D15.6-00pppppxsq~uq~ sq~Z$tF:protein bindingsq~Z$t&C:proteasome complex (sensu Eukaryota)ppppppppxsq~uq~ sq~$tF:peptidase activityt8233sq~$t C:cytosolt5829sq~$tC:protein complext43234pppppppxsq~uq~ sq~$t IPR001353tProteasome_A_Bpppppppppxsq~uq~ sq~$t ProteasometPF00227pppppppppxtQ5JNW7t Q5JNW7_HUMANsq~uq~ sq~$t!Large multifunctional peptidase 7sq~$t Large multifunctional protease 7ppppppppxt Homo sapienstECBP2sq~P?{NR%t!EF-hand calcium-binding protein 2sq~uq~ sq~UtENSG00000103154pppppppppxsq~uq~ sq~mtEFCBP2sq~mtNECAB2ppppppppxsq~-uq~ Psq~ZDt$P:protein amino acid phosphorylationsq~ZOt0P:regulation of cyclin-dependent protein kina...sq~Zw9t%P:androgen receptor signaling pathwaysq~Zt/P:transcription from RNA polymerase II promotersq~Z]tP:muscle developmentsq~ZtP:chromosome segregationsq~Zlt P:proteolysissq~Zt0P:transcription initiation from RNA polymeras...sq~Zt,P:regulation of transcription, DNA-dependentsq~Zt0P:generation of precursor metabolites and energysq~Z@tP:protein deubiquitinationsq~Zuwt0P:regulation of mitotic metaphase/anaphase tr...sq~Zxt0P:positive regulation of transcription from R...sq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~Zt$P:DNA fragmentation during apoptosissq~ZtF:protein bindingsq~ZtF:signal transducer activitysq~ZttF:transcription factor activitysq~Zt F:RNA bindingsq~Zt F:ATP bindingsq~Z9tF:vitamin D receptor bindingsq~Z NtF:zinc ion bindingsq~Zw3tF:snoRNA bindingsq~Zvt0F:ligand-dependent nuclear receptor transcrip...sq~Zvt"F:thyroid hormone receptor bindingsq~Z2tF:identical protein bindingsq~Zt&F:ubiquitin-specific protease activitysq~Z@tF:protein kinase activitysq~ZBt*F:protein serine/threonine kinase activitysq~ZtF:receptor activitysq~ZtF:calcium ion bindingsq~Zt.F:caspase-activated deoxyribonuclease activitysq~Zft0F:calcium-dependent cysteine-type endopeptida...sq~Zet&F:cysteine-type endopeptidase activitysq~Z@Gt0F:RNA polymerase II transcription mediator ac...sq~ZtF:magnesium ion bindingsq~Zt C:nucleussq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Zt C:polysomesq~Zdt+C:small nucleolar ribonucleoprotein complexsq~Zit C:cytoplasmsq~Zt C:cytosolsq~ZtC:intracellularsq~ZwtC:mediator complexpppppppppppppppppppppppppppppppppppxpsq~uq~ sq~t IPR007138tAntibiotic_mOasesq~t IPR011992t EF-Hand_typesq~t IPR002048t EF_hand_Ca_bdpppppppxsq~uq~ sq~tABMtPF03992sq~tefhandtPF00036ppppppppxtQ7Z6G3t ECBP2_HUMANsq~uq~ sq~t"Neuronal calcium-binding protein 2sq~t#Synaptotagmin-interacting protein 2sq~tStip-2pppppppxt Homo sapienstIDH3Gsq~P?UUUUUa1%%tEIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursorsq~uq~ sq~U1%tENSG00000067829pppppppppxsq~uq~ sq~m1%tIDH3Gpppppppppxsq~ uq~ sq~ZW1%t P:carbohydrate metabolic processsq~Z1%tP:isocitrate metabolic processsq~Z1%t F:RNA bindingsq~Za1%t*F:isocitrate dehydrogenase (NAD+) activitysq~Z#_1%tF:electron carrier activitysq~Z1%t&C:proteasome complex (sensu Eukaryota)sq~Z1%t C:nucleussq~Zk1%tC:mitochondrionsq~Z1%t C:polysomepxsq~uq~ sq~1%t P:carbohydrate metabolic processt5975sq~1%t*F:isocitrate dehydrogenase (NAD+) activityt4449sq~1%tC:mitochondriont5739pppppppxsq~uq~ sq~1%t IPR001804tIDH_IMDHsq~1%t IPR004434t IDH_NAD_mitppppppppxsq~uq~ sq~1%tIso_dhtPF00180pppppppppxtP51553t IDH3G_HUMANsq~uq~ sq~1%tIsocitric dehydrogenasesq~1%tNAD(+)-specific ICDHppppppppxt Homo sapienstATG5sq~P?~C2t3%tAutophagy protein 5sq~uq~ sq~UttENSG00000057663pppppppppxsq~uq~ sq~mttATG5sq~mttAPG5Lsq~mttASPpppppppxsq~puq~ sq~Z [ttP:cell proliferationsq~Z ]tt+P:negative regulation of cell proliferationsq~Z@ttP:protein modification processsq~Zott/P:ubiquitin-dependent protein catabolic processsq~ZttP:lipid metabolic processsq~Z tt P:translationsq~ZtttP:DNA replicationsq~ZttP:cell cycle arrestsq~Ztt P:autophagysq~Ztt P:apoptosissq~ZttP:caspase activationsq~ZttP:protein targetingsq~ZttP:cell motilitysq~ZttP:fatty acid beta-oxidationsq~ZDtt$P:protein amino acid phosphorylationsq~Ztt(P:purine nucleotide biosynthetic processsq~ZttP:purine ribonucleoside salvagesq~ZttP:DNA recombinationsq~ZttP:nucleosome assemblysq~ZttP:chromatin remodelingsq~ZOtt P:protein amino acid methylationsq~ZttP:translational elongationsq~Z9ttP:protein foldingsq~Z=ttP:protein complex assemblysq~ZHttP:ER-nuclear signaling pathwaysq~ZJttP:response to unfolded proteinsq~Zbtt*P:cytoskeleton organization and biogenesissq~Z#ttP:nucleotide metabolic processsq~Z$tt0P:pyrimidine ribonucleotide biosynthetic processsq~Z%tt$P:anatomical structure morphogenesissq~ZGtt0P:peptidyl-proline hydroxylation to 4-hydroxy...sq~ZuttP:protein repairsq~Ztt%P:regulation of macrophage activationsq~Z:tt"P:negative regulation of apoptosissq~ZDtt0P:negative regulation of transcription, DNA-d...sq~Ztt0P:positive regulation of dopamine metabolic p...sq~Z!`ttP:epidermis developmentsq~ZYttP:protein homotetramerizationsq~ZttP:cell communicationsq~ZttP:signal transductionsq~Ztt0P:cell surface receptor linked signal transdu...sq~ZVtt P:JNK cascadesq~Zktt&P:multicellular organismal developmentsq~Z]ttP:muscle developmentsq~Ztt P:behaviorsq~Ztt&P:establishment of blood-nerve barriersq~Z \tt+P:positive regulation of cell proliferationsq~Ztt P:hypoxanthine metabolic processsq~ZJtt.P:regulation of progression through cell cyclesq~Ztt P:endocytosissq~Ztt$P:prostaglandin biosynthetic processsq~ZOtt0P:regulation of cyclin-dependent protein kina...sq~ZKttP:cell cycle checkpointsq~Z>xttP:proton transportsq~ZttF:protein bindingsq~Ztt F:RNA bindingsq~Ztt$F:structural constituent of ribosomesq~Z2ttF:identical protein bindingsq~ZTttF:GTPase activitysq~ZttF:actin bindingsq~Z}tt"F:ubiquitin thiolesterase activitysq~ZttF:enoyl-CoA hydratase activitysq~Z tt"F:glutathione transferase activitysq~ZFtt0F:hypoxanthine phosphoribosyltransferase acti...sq~Z0tt,F:procollagen-proline 4-dioxygenase activitysq~ZBtt*F:protein serine/threonine kinase activitysq~Z ttF:3'-5' exonuclease activitysq~Ztt&F:protein disulfide isomerase activitysq~ZǏttF:chaperone bindingsq~ZNJttF:unfolded protein bindingsq~ZttF:magnesium ion bindingsq~ZttF:phosphoinositide bindingsq~Z]tt F:DNA bindingsq~ZtttF:transcription factor activitysq~ZAttF:ATPase activitysq~ZbttF:IMP dehydrogenase activitysq~Z3tt#F:protein homodimerization activitysq~Ztt(F:translation elongation factor activitysq~Zott0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~Ztt/F:ribonucleoside-diphosphate reductase activitysq~ZttF:uridine kinase activitysq~ZttF:fatty acid bindingsq~ZxttF:steroid bindingsq~Z_ttF:transporter activitysq~ZttF:cytokine activitysq~ZttF:receptor bindingsq~Ztt)F:Rab GDP-dissociation inhibitor activitysq~Ztt0F:cyclin-dependent protein kinase inhibitor a...sq~Zi tt C:cytoplasmsq~Z tt C:nucleussq~Ztt&C:proteasome complex (sensu Eukaryota)sq~Z'ttC:cell surfacesq~ZttC:intracellularsq~ZttC:endoplasmic reticulumsq~Zytt0C:mitochondrial proton-transporting ATP synth...sq~ZkttC:mitochondrionsq~ZttC:extracellular regionsq~ZttC:integral to plasma membranesq~ZttC:plasma membranesq~ZStt.C:ribonucleoside-diphosphate reductase complexsq~Ztt C:polysomesq~ZttC:cytoskeletonsq~Ztt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Ztt#C:ER-Golgi intermediate compartmentsq~Ztt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Ztt0C:signal recognition particle, endoplasmic re...sq~ZttC:late endosomesq~Ztt C:lysosomesq~Z btt!C:F-actin capping protein complexsq~Zbtt C:nucleolussq~Z.ttC:chromatin assembly complexsq~Ztt0C:eukaryotic translation elongation factor 1 ...ppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~ttF:protein bindingt5515sq~ttC:autophagic vacuolet5776ppppppppxsq~uq~ sq~tt IPR007239tAPG5pppppppppxsq~uq~ sq~ttAPG5tPF04106pppppppppxtQ9H1Y0t ATG5_HUMANsq~uq~ sq~tt APG5-likesq~ttApoptosis-specific proteinppppppppxt Homo sapienst41sq~P?Q4WP%t Protein 4.1sq~uq~ sq~UPtENSG00000159023pppppppppxsq~uq~ sq~mPtEPB41sq~mPtE41Pppppppppxsq~Suq~ sq~ZPtP:signal transductionsq~Z9PtP:protein foldingsq~ZJPt.P:regulation of progression through cell cyclesq~Z [PtP:cell proliferationsq~Z?PtP:cell-cell adhesionsq~Z]PtP:muscle developmentsq~ZPtP:translational elongationsq~Z:PtP:protein transportsq~Z`Pt+P:small GTPase mediated signal transductionsq~ZPt,P:regulation of transcription, DNA-dependentsq~ZoPt/P:ubiquitin-dependent protein catabolic processsq~Z ]Pt+P:negative regulation of cell proliferationsq~ZsPt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZPt P:behaviorsq~ZgPtP:actin filament organizationsq~Z&PtP:organ morphogenesissq~Z>Pt P:cell growthsq~ZPtP:muscle contractionsq~ZPtP:anti-apoptosissq~ZPtP:cell adhesionsq~ZPt(P:ER to Golgi vesicle-mediated transportsq~ZPtP:lipid metabolic processsq~Z Pt P:translationsq~ZPt(P:nuclear mRNA splicing, via spliceosomesq~Z.Pt(P:regulation of translational initiationsq~ZPt0P:epidermal growth factor receptor signaling ...sq~ZUPt%P:nuclear organization and biogenesissq~Z Pt0P:transforming growth factor beta receptor si...sq~ZPt0P:dopamine receptor, adenylate cyclase inhibi...sq~Z&PtP:response to stresssq~Z"PtP:phospholipase C activationsq~ZPtP:fatty acid beta-oxidationsq~ZPt"P:regulation of muscle contractionsq~ZPtP:cell-matrix adhesionsq~ZjPtP:microtubule-based movementsq~ZPtP:cell communicationsq~ZPt0P:establishment and/or maintenance of cell po...sq~ZPt0P:cell surface receptor linked signal transdu...sq~ZPt0P:traversing start control point of mitotic c...sq~ZPtP:cell cycle arrestsq~ZPtP:regulation of mitosissq~ZPt0P:transmembrane receptor protein tyrosine kin...sq~ZlPtP:microtubule nucleationsq~ZJPtP:response to unfolded proteinsq~ZPtP:cell motilitysq~ZmPt)P:membrane protein ectodomain proteolysissq~ZlPt P:proteolysissq~Z]Pt+P:protein amino acid O-linked glycosylationsq~ZWPt+P:protein amino acid N-linked glycosylationsq~ZOPt P:protein amino acid methylationsq~ZEPt0P:negative regulation of protein kinase activitysq~ZDPt$P:protein amino acid phosphorylationsq~Z@PtP:protein modification processsq~ZPtP:regulation of translationsq~Z PtP:translational initiationsq~ZPt/P:transcription from RNA polymerase II promotersq~ZPt0P:regulation of transcription from RNA polyme...sq~ZPtP:DNA recombinationsq~ZPt+P:NLS-bearing substrate import into nucleussq~ZPtP:protein export from nucleussq~ZPt$P:protein targeting to mitochondrionsq~ZPtP:caspase activationsq~ZPtP:induction of apoptosissq~ZPt(P:intra-Golgi vesicle-mediated transportsq~ZPt0P:retrograde vesicle-mediated transport, Golg...sq~ZPtP:DNA modificationsq~ZPt!P:intracellular protein transportsq~ZPt!P:cellular copper ion homeostasissq~ZPt"P:cellular calcium ion homeostasissq~ZPtP:cellular ion homeostasissq~ZPtP:chloride transportsq~ZPtP:anion transportsq~ZPt P:transportsq~Z&PtP:steroid biosynthetic processsq~ZPt$P:DNA fragmentation during apoptosissq~ZePtP:cell divisionsq~ZPtP:cell redox homeostasissq~ZuPt0P:positive regulation of nitric oxide biosynt...sq~ZPtP:cellular respirationsq~ZPt)P:blood vessel endothelial cell migrationsq~ZPt&P:positive regulation of MAPK activitysq~Z:Pt"P:negative regulation of apoptosissq~ZPt%P:regulation of macrophage activationsq~ZPt/P:calcium-dependent phospholipase A2 activationsq~ZPtP:regulation of apoptosissq~ZWPt(P:positive regulation of phosphorylationsq~Z~Pt0P:negative regulation of intracellular transportsq~Z{WPtP:G1/S transition checkpointsq~Z{,Pt#P:actin cytoskeleton reorganizationsq~Z`Pt&P:regulation of neuron differentiationsq~ZjPt0P:negative regulation of progression through ...sq~ZPt0P:positive regulation of dopamine metabolic p...sq~ZYPtP:protein homotetramerizationsq~ZPt!P:protein insertion into membranesq~ZǔPt.P:activation of NF-kappaB transcription factorsq~Z7Pt.P:regulation of nitric-oxide synthase activitysq~ZPtP:neuromuscular processsq~ZPtP:leukocyte migrationsq~Z*Pt0P:regulation of peptidyl-tyrosine phosphoryla...sq~ZPt0P:positive regulation of epithelial cell prol...sq~Z'Pt#P:regulation of synaptic plasticitysq~ZPt%P:phosphoinositide-mediated signalingsq~ZPt+P:mitochondrion transport along microtubulesq~ZPtP:microtubule polymerizationsq~ZPt P:hypoxanthine metabolic processsq~ZyPt0P:negative regulation of microtubule polymeri...sq~ZxPt0P:cortical actin cytoskeleton organization an...sq~ZvPt'P:positive regulation of cell migrationsq~Z!`PtP:epidermis developmentsq~Z PtP:regulation of cell shapesq~Z \Pt+P:positive regulation of cell proliferationsq~ZPt(P:negative regulation of DNA replicationsq~ZPt0P:regulation of actin polymerization and/or d...sq~ZPPt!P:regulation of heart contractionsq~ZOPt P:circulationsq~ZPtP:sensory perception of soundsq~ZPtP:respiratory gaseous exchangesq~ZPtP:nervous system developmentsq~Z|PtP:female gamete generationsq~ZdPtP:synaptic transmissionsq~Z=Pt%P:integrin-mediated signaling pathwaysq~Z!Pt%P:caspase activation via cytochrome csq~Z#Pt"P:purine base biosynthetic processsq~Z%Pt$P:anatomical structure morphogenesissq~Zv PtP:muscle thin filament assemblysq~ZvPtP:monocyte differentiationsq~Zv PtP:platelet formationsq~ZuPtP:neuron differentiationsq~ZuPtP:cell differentiationsq~ZuPtP:protein repairsq~Zu`PtP:actin filament-based movementsq~ZuTPt0P:actin cytoskeleton organization and biogenesissq~ZGgPt0P:protein amino acid N-linked glycosylation v...sq~Z@aPt&P:negative regulation of transcriptionsq~Z?JPt+P:regulation of striated muscle developmentsq~Z?@PtP:vesicle-mediated transportsq~Z&Pt#P:regulation of signal transductionsq~Z,Pt%P:dopamine receptor signaling pathwaysq~ZPt P:cytokinesissq~ZUPt P:G2 phase of mitotic cell cyclesq~ZVPt'P:G2/M transition of mitotic cell cyclesq~ZZPtP:mitotic anaphasesq~ZhPt0P:cis assembly of U2-type pre-catalytic splic...sq~ZPtP:protein polyubiquitinationsq~ZPtP:ossificationsq~ZPt$P:prostaglandin biosynthetic processsq~ZPtP:angiogenesissq~ZPt0P:dopamine receptor, phospholipase C activati...sq~ZPt P:endothelial cell proliferationsq~ZOPt0P:regulation of cyclin-dependent protein kina...sq~ZKPtP:cell cycle checkpointsq~ZPtP:regulation of DNA repairsq~ZPt P:DNA repairsq~ZPtP:regulation of DNA replicationsq~ZtPtP:DNA replicationsq~Z-Pt$P:'de novo' IMP biosynthetic processsq~ZPtP:purine ribonucleoside salvagesq~ZPt(P:purine nucleotide biosynthetic processsq~ZHPt&P:M phase specific microtubule processsq~ZPtP:visual behaviorsq~ZPt!P:regulation of DNA recombinationsq~Z8PtF:protein bindingsq~Z2PtF:identical protein bindingsq~ZPt F:RNA bindingsq~ZPt F:ATP bindingsq~ZPPt(F:structural constituent of cytoskeletonsq~ZPtF:actin bindingsq~ZGPtF:actin filament bindingsq~Z!PtF:guanylate kinase activitysq~Z3Pt#F:protein homodimerization activitysq~ZPt$F:structural constituent of ribosomesq~Z sPt"F:structural constituent of musclesq~ZPt F:GTP bindingsq~ZPtF:motor activitysq~ZPt(F:translation elongation factor activitysq~ZXPtF:dopamine receptor activitysq~ZTPtF:GTPase activitysq~Z]Pt F:DNA bindingsq~ZVPtF:protein C-terminus bindingsq~ZpPt F:bindingsq~Z_PtF:transporter activitysq~ZPt%F:GDP-dissociation inhibitor activitysq~ZPtF:enoyl-CoA hydratase activitysq~ZAPtF:ATPase activitysq~ZPt#F:ubiquitin-protein ligase activitysq~Z"Pt0F:phosphoribosylformylglycinamidine synthase ...sq~ZPt0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~ZFPt0F:hypoxanthine phosphoribosyltransferase acti...sq~ZǏPtF:chaperone bindingsq~ZNJPtF:unfolded protein bindingsq~ZBPtF:microtubule plus-end bindingsq~Z@Pt"F:transcription activator activitysq~Z@Pt-F:specific transcriptional repressor activitysq~ZPtF:microfilament motor activitysq~ZB~PtF:myosin bindingsq~ZUPt*F:cyclin-dependent protein kinase activitysq~Z=PtF:tubulin bindingsq~ZPt C:membranesq~ZPt C:spectrinsq~ZPt C:cytosolsq~ZPtC:protein complexsq~ZPtC:endoplasmic reticulumsq~ZPtC:stress fibersq~ZPtC:cytoskeletonsq~ZWPt!C:perinuclear region of cytoplasmsq~Z}PtC:cleavage furrowsq~ZPtC:membrane fractionsq~Z1Pt C:spliceosomesq~ZPtC:rufflesq~ZbPt C:nucleolussq~ZPt"C:muscle thin filament tropomyosinsq~ZPtC:soluble fractionsq~Z'PtC:cell surfacesq~Z@KPtC:myosin complexsq~Z= PtC:actin cytoskeletonsq~ZxPtC:cortical cytoskeletonsq~ZPtC:extracellular regionsq~ZPtC:cytoplasmic dynein complexsq~ZPtC:contractile ringsq~ZPtC:intermediate filamentsq~ZPtC:actin filamentsq~ZPtC:intercellular junctionsq~ZPtC:condensed nuclear chromosomesq~ZPtC:brush bordersq~Z2Pt C:cell cortexsq~ZPt+C:proteasome core complex (sensu Eukaryota)sq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZPtC:muscle myosin complexsq~ZPtC:spindle microtubulesq~ZPtC:ubiquitin ligase complexsq~ZPt0C:eukaryotic translation elongation factor 1 ...sq~ZPtC:striated muscle thin filamentsq~ZPt C:microtubulesq~ZPt C:polysomesq~ZPt%C:protein phosphatase type 2A complexsq~ZPt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZPtC:spindle polesq~ZPtC:Golgi apparatussq~ZPtC:endoplasmic reticulum lumensq~ZzPt&C:ubiquitin conjugating enzyme complexsq~ZyPt#C:cortical microtubule cytoskeletonsq~Zw Pt C:midbodysq~ZPt C:ribosomesq~ZPtC:extracellular spacesq~ZuPtC:COPI vesicle coatsq~Z?PtC:basolateral plasma membranesq~Z?Pt0C:eukaryotic translation initiation factor 4F...sq~Z>PtC:integral to membranesq~Z :Pt$C:oligosaccharyl transferase complexsq~Z SPtC:gamma-tubulin small complexsq~ZPtC:nuclear envelopesq~ZPt C:nucleoplasmsq~Z|PtC:nuclear membranesq~ZPt.C:signal recognition particle receptor complexsq~ZPt C:peroxisomesq~ZPt C:endosomesq~ZPtC:mitochondrial matrixsq~Z~Pt#C:mitochondrial intermembrane spacesq~ZyPt0C:mitochondrial proton-transporting ATP synth...sq~ZpPt0C:mitochondrial inner membrane presequence tr...sq~ZoPtC:mitochondrial inner membranesq~ZPt(C:NuA4 histone acetyltransferase complexsq~Z2Pt C:snRNP U5sq~ZPt"C:DNA replication factor C complexsq~Z:Pt C:Cajal bodypppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Pt0P:actin cytoskeleton organization and biogenesist30036sq~Pt P:circulationt8015sq~PtF:phosphatidylinositol bindingt5545sq~PtF:protein bindingt5515sq~Pt(F:structural constituent of cytoskeletont5200sq~PtC:plasma membranet5886sq~PtC:protein complext43234sq~Pt C:spectrint8091ppxsq~uq~ sq~Pt IPR008379t Band_4.1_Csq~Pt IPR000299t Band_4.1_Nsq~Pt IPR000798t Ez/rad/moesinsq~Pt IPR014847t FERM-adjacentsq~Pt IPR014352t FERM-typesq~Pt IPR011993tPH_typesq~Pt IPR007477tSABpppxsq~uq~ sq~Pt4_1_CTDtPF05902sq~PtBand_41tPF00373sq~PtFAtPF08736sq~PtSABtPF04382ppppppxtP11171t41_HUMANsq~uq~ sq~PtBand 4.1sq~PtP4.1sq~PtEPB4.1sq~Pt4.1Rppppppxt Homo sapienstILKsq~P?[`(GfG%tIntegrin-linked protein kinasesq~uq~ sq~UftENSG00000166333pppppppppxsq~uq~ sq~mftILKsq~mftILK1sq~mftILK2pppppppxsq~uq~ sq~ZJft!P:intracellular signaling cascadesq~ZftP:signal complex assemblysq~Z ^ft$P:insulin receptor signaling pathwaysq~ZftP:cell adhesionsq~ZJftP:response to unfolded proteinsq~Z*ftP:inflammatory responsesq~ZFft!P:peptidyl-serine phosphorylationsq~ZftP:anti-apoptosissq~ZftP:rRNA processingsq~ZftP:nucleotide-excision repairsq~ZcftP:cell-cell signalingsq~Z:ft"P:negative regulation of apoptosissq~ZftP:homophilic cell adhesionsq~ZftP:leukocyte adhesionsq~ZftP:protein export from nucleussq~ZftP:cell-matrix adhesionsq~ZftP:signal transductionsq~Zft0P:cell surface receptor linked signal transdu...sq~Zlft P:proteolysissq~Zft0P:regulation of epidermal growth factor recep...sq~Zft0P:G-protein coupled receptor protein signalin...sq~Z'ft"P:cholesterol biosynthetic processsq~ZftP:lipid metabolic processsq~ZGftP:ER overload responsesq~Zft#P:nitric oxide biosynthetic processsq~Zft0P:retrograde vesicle-mediated transport, Golg...sq~Zft(P:intra-Golgi vesicle-mediated transportsq~Zft P:apoptosissq~ZftP:caspase activationsq~Z ftP:activated T cell apoptosissq~ZftP:cell motilitysq~Z8ftP:cellular defense responsesq~Zjft!P:GPI anchor biosynthetic processsq~Z=ft%P:integrin-mediated signaling pathwaysq~Z`ft+P:small GTPase mediated signal transductionsq~Zv]ftP:cholesterol transportsq~ZwftP:neutrophil chemotaxissq~Zxvft0P:positive regulation of actin filament polym...sq~Zft+P:protein amino acid O-linked mannosylationsq~Zft)P:retrograde transport, endosome to Golgisq~ZftP:cholesterol homeostasissq~Zft%P:regulation of macrophage activationsq~Zsft0P:positive regulation of I-kappaB kinase/NF-k...sq~ZEft0P:positive regulation of transcription, DNA-d...sq~Zft(P:protein amino acid autophosphorylationsq~Zft0P:positive regulation of protein export from ...sq~Zft0P:insulin-like growth factor receptor signali...sq~ZuTft0P:actin cytoskeleton organization and biogenesissq~ZGft0P:protein amino acid C-linked glycosylation v...sq~Zft0P:Wnt receptor signaling pathway through beta...sq~ZEft)P:pyrimidine nucleoside metabolic processsq~Zft P:cell agingsq~ZftP:blood coagulationsq~Z [ftP:cell proliferationsq~Z ]ft+P:negative regulation of cell proliferationsq~Z ftP:regulation of cell shapesq~Z!ftP:apoptotic programsq~Z!ft%P:caspase activation via cytochrome csq~Z$ft0P:folic acid and derivative biosynthetic processsq~Z$ftP:response to heatsq~Z%ftP:response to hormone stimulussq~Z@]ftP:cell migrationsq~Z*ft0P:regulation of peptidyl-tyrosine phosphoryla...sq~Zvft-P:positive regulation of T cell proliferationsq~Zft0P:two-component signal transduction system (p...sq~Zft$P:prostaglandin biosynthetic processsq~Zft)P:nuclear mRNA 3'-splice site recognitionsq~ZJft.P:regulation of progression through cell cyclesq~Z<ft,P:protein import into nucleus, translocationsq~Z;ft&P:protein import into nucleus, dockingsq~Z9ftP:protein foldingsq~Z.ft(P:regulation of translational initiationsq~ZftP:RNA processingsq~Zft0P:nucleobase, nucleoside, nucleotide and nucl...sq~ZDft$P:protein amino acid phosphorylationsq~ZvftP:glucose metabolic processsq~ZYftP:glycogen metabolic processsq~Z/ftF:protein bindingsq~Z2ftF:identical protein bindingsq~Zft F:RNA bindingsq~ZftF:signal transducer activitysq~Zuft.F:receptor signaling complex scaffold activitysq~ZwftF:caspase activitysq~Zft F:ATP bindingsq~ZftF:acid phosphatase activitysq~Zft%F:ATP-dependent RNA helicase activitysq~ZMftF:protein kinase bindingsq~Zft!F:acetyl-CoA carboxylase activitysq~Z<}ftF:cholesterol bindingsq~ZfftF:ketohexokinase activitysq~Z}ft0F:methenyltetrahydrofolate cyclohydrolase act...sq~ZIft0F:dolichyl-phosphate-mannose-protein mannosyl...sq~ZftF:actin bindingsq~Zv{ftF:estrogen receptor bindingsq~ZNJftF:unfolded protein bindingsq~ZsftF:NF-kappaB bindingsq~Zft)F:7-dehydrocholesterol reductase activitysq~Zft%F:protein heterodimerization activitysq~Zft F:p53 bindingsq~Zft*F:formate-tetrahydrofolate ligase activitysq~ZdftF:damaged DNA bindingsq~Zft$F:transcription coactivator activitysq~ZǏftF:chaperone bindingsq~ZwftF:protein binding, bridgingsq~Zft0F:methylenetetrahydrofolate dehydrogenase (NA...sq~Zft0F:dolichyl-phosphate beta-D-mannosyltransfera...sq~Zft)F:nuclear export signal receptor activitysq~ZftF:enzyme inhibitor activitysq~ZoftF:enzyme activator activitysq~ZNftF:structural molecule activitysq~Zft!F:methionine-tRNA ligase activitysq~Zft0F:[pyruvate dehydrogenase (lipoamide)] kinase...sq~ZXft%F:glycogen synthase kinase 3 activitysq~ZftF:calcium ion bindingsq~ZftF:cytoskeletal adaptor activitysq~ZDft0F:3-phosphoinositide-dependent protein kinase...sq~ZCftF:vinculin bindingsq~Z!uftF:protein transporter activitysq~ZBft*F:protein serine/threonine kinase activitysq~ZftF:cytokine activitysq~Zi ft C:cytoplasmsq~ZkftC:mitochondrionsq~ZftC:cytoskeletonsq~Z qftC:integrin complexsq~ZftC:endoplasmic reticulumsq~Zft C:nucleussq~ZuftC:COPI vesicle coatsq~Z ftC:nuclear poresq~ZftC:extracellular regionsq~ZftC:plasma membranesq~Zft C:cytosolsq~Z{ ftC:mannosyltransferase complexsq~Zft C:endoplasmic reticulum membranesq~ZftC:integral to plasma membranesq~ZftC:Golgi membranesq~Zft C:microtubule associated complexsq~ZAft C:lipid raftsq~Zft&C:proteasome complex (sensu Eukaryota)sq~Z@ftC:caveolar membranesq~ZwBft0C:heterogeneous nuclear ribonucleoprotein com...sq~ZwDft)C:small nuclear ribonucleoprotein complexsq~Zxft"C:beta-catenin destruction complexsq~ZftC:nuclear outer membranesq~Zft C:nucleoplasmsq~Z+ftC:holo TFIIH complexsq~ZftC:rufflesq~Z1ft C:spliceosomesq~Zbft C:nucleolussq~Z'ftC:cell surfacepppppppppppxsq~uq~ sq~ftP:cell proliferationt8283sq~ftP:cell-matrix adhesiont7160sq~ft%P:integrin-mediated signaling pathwayt7229sq~ft$P:protein amino acid phosphorylationt6468sq~ft F:ATP bindingt5524sq~ftF:protein bindingt5515sq~ft*F:protein serine/threonine kinase activityt4674sq~ft C:cytoplasmt5737ppxsq~uq~ sq~ft IPR002110tANKsq~ft IPR000719tProt_kinase_coresq~ft IPR008271tSer_thr_pkin_ASsq~ft IPR001245t Tyr_pkinaseppppppxsq~uq~ sq~ftAnktPF00023sq~ft Pkinase_TyrtPF07714ppppppppxtQ13418t ILK_HUMANsq~uq~ sq~ftILK-1sq~ftILK-2sq~ft&59 kDa serine/threonine-protein kinasesq~ftp59ILKppppppxt Homo sapienstQ7Z3B5sq~Ps.%t.Putative uncharacterized protein DKFZp686I0180sq~uq~ sq~Us.tENSG00000100804pppppppppxsq~uq~ sq~ms.t DKFZp686I0180pppppppppxsq~uq~ sq~Zs.tF:protein bindingsq~Zs.t&C:proteasome complex (sensu Eukaryota)sq~Zis.t C:cytoplasmpppppppxsq~uq~ sq~s.t/P:ubiquitin-dependent protein catabolic processt6511sq~s.tF:endopeptidase activityt4175sq~s.t+C:proteasome core complex (sensu Eukaryota)t5839pppppppxsq~uq~ sq~s.t IPR000243t Pept_T1A_subBsq~s.t IPR001353tProteasome_A_Bppppppppxsq~uq~ sq~s.t ProteasometPF00227pppppppppxtQ7Z3B5t Q7Z3B5_HUMANpt Homo sapienstQ53X72sq~P%t CCNH proteinsq~uq~ sq~UtENSG00000134480pppppppppxsq~uq~ sq~mtCCNHpppppppppxsq~uq~ sq~Zt P:mitosissq~Zt F:RNA bindingsq~ZtF:protein bindingsq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zt C:nucleussq~Zt C:polysomeppppxsq~uq~ sq~t P:cell cyclet7049pppppppppxsq~uq~ sq~t IPR005258tCcl1sq~t IPR015432tCycHsq~t IPR006670tCyclinsq~t IPR006671tCyclin_Nsq~t IPR013763tCyclin_relatedsq~t IPR015429tTrans_reg_cyclinppppxsq~uq~ sq~tCyclin_NtPF00134pppppppppxtQ53X72t Q53X72_HUMANpt Homo sapienstLSM1sq~P?N/Қ%t(U6 snRNA-associated Sm-like protein LSm1sq~uq~ sq~UtENSG00000175324pppppppppxsq~uq~ sq~mtLSM1sq~mtCASMppppppppxsq~Luq~ Psq~ZtP:mRNA processingsq~Zt(P:nuclear mRNA splicing, via spliceosomesq~Z tP:RNA splicingsq~ZtP:signal transductionsq~ZKtP:fatty acid oxidationsq~Z&tP:hormone-mediated signalingsq~Zt P:excretionsq~Zt$P:central nervous system developmentsq~ZJtP:response to unfolded proteinsq~ZtP:mitochondrial transportsq~ZtP:chloride transportsq~ZFt&P:protein amino acid dephosphorylationsq~ZEt0P:negative regulation of protein kinase activitysq~ZtP:mRNA export from nucleussq~Zv tP:T cell differentiationsq~Z*tP:protein refoldingsq~ZɗtP:defense response to virussq~Zat(P:centrosome organization and biogenesissq~Z t0P:release of sequestered calcium ion into cyt...sq~ZƩt0P:positive regulation of antigen receptor-med...sq~Zƥt#P:B cell receptor signaling pathwaysq~ZƤt#P:T cell receptor signaling pathwaysq~Zt+P:mitochondrion transport along microtubulesq~Zut&P:positive regulation of transcriptionsq~Z$t0P:positive regulation of protein kinase activitysq~Zut0P:positive regulation of nitric oxide biosynt...sq~Zvt-P:positive regulation of T cell proliferationsq~ZttP:B cell proliferationsq~ZtP:regulation of cell cyclesq~ZtP:electron transportsq~Zt0P:microtubule cytoskeleton organization and b...sq~Zt0P:negative regulation of cytokine and chemoki...sq~Zt0P:mRNA catabolic process, nonsense-mediated d...sq~Z{t0P:negative regulation of T cell mediated cyto...sq~Zt P:in utero embryonic developmentsq~ZtP:response to hypoxiasq~ZtP:spliceosome assemblysq~ZtF:protein bindingsq~ZBtF:U6 snRNA bindingsq~Zv;t&F:glyoxylate reductase (NADP) activitysq~ZxtF:TPR domain bindingsq~Zt0F:aryl hydrocarbon receptor nuclear transloca...sq~Zt0F:transmembrane receptor protein tyrosine pho...sq~Zt!F:asparagine-tRNA ligase activitysq~ZBtF:hormone bindingsq~Z2tF:identical protein bindingsq~Z3t#F:protein homodimerization activitysq~Zt F:RNA bindingsq~ZttF:transcription factor activitysq~ZgtF:beta-tubulin bindingsq~ZWt F:NAD bindingsq~Zvt*F:nitric-oxide synthase regulator activitysq~ZtF:chloride channel activitysq~Z!t"F:glycerate dehydrogenase activitysq~Z!utF:protein transporter activitysq~Zt F:ATP bindingsq~Zt%F:protein heterodimerization activitysq~Z@t$F:hydroxypyruvate reductase activitysq~ZC t#F:aryl hydrocarbon receptor bindingsq~ZQtF:microtubule bindingsq~ZMtF:protein kinase bindingsq~Z t C:nucleussq~Zit C:cytoplasmsq~Zt C:cytosolsq~ZtC:soluble fractionsq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZwDt)C:small nuclear ribonucleoprotein complexsq~ZtC:brush bordersq~ZtC:integral to plasma membranesq~Z%tC:focal adhesionsq~Zt C:centrosomesq~Z:t C:Cajal bodysq~Z8t C:snRNP U6sq~ZtC:nuclear envelopesq~ZtC:membrane fractionsq~ZtC:gamma-tubulin complexppppxsq~uq~ sq~tP:mRNA processingt6397sq~tP:RNA splicingt8380sq~tF:protein bindingt5515sq~t0F:RNA splicing factor activity, transesterifi...t31202sq~t C:nucleust5634pppppxsq~uq~ sq~t IPR006649tEuk_arc_LSM_coresq~t IPR001163tLSM_snRNP_coreppppppppxsq~uq~ sq~tLSMtPF01423pppppppppxtO15116t LSM1_HUMANsq~uq~ sq~tSmall nuclear ribonuclear CaSmsq~tCancer-associated Sm-likeppppppppxt Homo sapienstRUXFsq~P?sF\ї/A3%t!Small nuclear ribonucleoprotein Fsq~uq~ sq~UA3tENSG00000139343pppppppppxsq~uq~ sq~mA3tSNRPFsq~mA3tPBSCFppppppppxsq~2uq~ Psq~ZA3tP:spliceosome assemblysq~ZA3tP:mRNA processingsq~ZA3t$P:assembly of spliceosomal tri-snRNPsq~ZA3t!P:intercellular junction assemblysq~ZhA3tP:cytoskeletal anchoringsq~ZA3tP:cell motilitysq~ZDA3t$P:protein amino acid phosphorylationsq~ZA3tP:oxidative phosphorylationsq~ZA3tP:cell adhesionsq~Z A3tP:RNA splicingsq~Z#dA3tP:aerobic respirationsq~Z%A3t$P:anatomical structure morphogenesissq~ZA3tP:spliceosomal snRNP biogenesissq~ZA3t)P:nuclear mRNA 3'-splice site recognitionsq~Z!A3tP:apical junction assemblysq~Z9A3t"P:positive regulation of apoptosissq~ZA3tP:base-excision repairsq~ZuPA3tP:lamellipodium biogenesissq~ZvA3t'P:negative regulation of cell migrationsq~ZA3tP:electron transportsq~ZA3tF:protein bindingsq~ZA3t F:RNA bindingsq~ZeA3t#F:MAP kinase kinase kinase activitysq~ZA3t%F:ATP-dependent RNA helicase activitysq~Z@kA3tF:oxidoreductase activitysq~Z!VA3t0F:oxidized purine base lesion DNA N-glycosyla...sq~ZPA3t(F:structural constituent of cytoskeletonsq~ZA3t+F:ubiquinol-cytochrome-c reductase activitysq~ZCA3tF:vinculin bindingsq~ZdA3tF:damaged DNA bindingsq~ZA3t F:ATP bindingsq~ZvBA3tF:LIM domain bindingsq~ZA3tF:alpha-catenin bindingsq~ZA3tF:RNA helicase activitysq~ZiA3t C:cytoplasmsq~ZwDA3t)C:small nuclear ribonucleoprotein complexsq~Z1A3t C:spliceosomesq~ZA3t C:nucleussq~ZA3tC:intercellular junctionsq~Z%A3tC:focal adhesionsq~ZA3tC:cytoskeletonsq~ZA3t C:nucleoplasmsq~Z9A3tC:U12-dependent spliceosomesq~ZrA3t!C:mitochondrial respiratory chainsq~Z@A3tC:nuclear bodysq~ZA3t C:costameresq~ZA3tC:rufflesq~ZA3tC:protein complexsq~ZA3t&C:proteasome complex (sensu Eukaryota)sq~Z:A3t C:Cajal bodyppppppppppppppppppppppppppppppxsq~uq~ sq~A3tP:RNA splicingt8380sq~A3tF:protein bindingt5515sq~A3t)C:small nuclear ribonucleoprotein complext30532sq~A3t C:spliceosomet5681ppppppxsq~uq~ sq~A3t IPR006649tEuk_arc_LSM_coresq~A3t IPR001163tLSM_snRNP_coreppppppppxsq~uq~ sq~A3tLSMtPF01423pppppppppxtP62306t RUXF_HUMANsq~uq~ sq~A3tsnRNP-Fsq~A3t Sm protein Fsq~A3tSm-Fsq~A3tSmFppppppxt Homo sapienst1C04sq~P?(tj(%tBHLA class I histocompatibility antigen, Cw-4 alpha chain precursorsq~uq~ sq~UtjtENSG00000206452pppppppppxsq~uq~ sq~mtjtHLA-Csq~mtjtHLACppppppppxsq~\uq~ sq~ZJtjt.P:regulation of progression through cell cyclesq~Z [tjtP:cell proliferationsq~Z+tjtP:immune responsesq~ZMtjt%P:antigen processing and presentationsq~ZVtjt"P:protein amino acid glycosylationsq~ZntjtP:ATP-dependent proteolysissq~Zotjt/P:ubiquitin-dependent protein catabolic processsq~Ztjt!P:intracellular protein transportsq~ZtjtP:cell motilitysq~Z*tjtP:inflammatory responsesq~ZOtjt P:protein amino acid methylationsq~Z.tjt(P:regulation of translational initiationsq~ZtjtP:translational elongationsq~Z tjt P:translationsq~Ztjt0P:regulation of transcription from RNA polyme...sq~Ztjt P:DNA repairsq~Z~tjtP:DNA replication initiationsq~ZttjtP:DNA replicationsq~ZatjtP:CTP biosynthetic processsq~Zntjt%P:chaperonin-mediated tubulin foldingsq~ZtjtP:regulation of mitosissq~Znjtjt#P:posttranslational protein foldingsq~Z-tjt&P:epithelial to mesenchymal transitionsq~Ztjt%P:phosphoinositide-mediated signalingsq~Ztjt0P:positive regulation of gene-specific transc...sq~ZtjtP:response to drugsq~Zytjt0P:negative regulation of microtubule polymeri...sq~ZKtjt"P:leukotriene biosynthetic processsq~Z>tjtP:mRNA metabolic processsq~ZtjtP:mRNA processingsq~Ztjt0P:cell surface receptor linked signal transdu...sq~Ztjt0P:G-protein coupled receptor protein signalin...sq~Zktjt&P:multicellular organismal developmentsq~ZatjtP:tRNA processingsq~Ztjt&P:establishment of blood-nerve barriersq~Z#tjt"P:purine base biosynthetic processsq~Ztjt P:glycolysissq~ZtjtF:protein bindingsq~Ztjt F:RNA bindingsq~Z~tjtF:MHC class I receptor activitysq~ZWtjt F:NAD bindingsq~Z+tjtF:CTP synthase activitysq~ZbtjtF:IMP dehydrogenase activitysq~Z tjtF:selenium bindingsq~Ztjt0F:UDP-glucose:glycoprotein glucosyltransferas...sq~Z NtjtF:zinc ion bindingsq~Z )tjtF:peptidase activitysq~ZtjtF:N-methyltransferase activitysq~Ztjt)F:acetyl-CoA C-acetyltransferase activitysq~Ztjt%F:carbonyl reductase (NADPH) activitysq~ZAtjtF:ATPase activitysq~Ztjt(F:translation elongation factor activitysq~Ztjt(F:translation initiation factor activitysq~ZNJtjtF:unfolded protein bindingsq~ZBtjtF:microtubule plus-end bindingsq~Z]tjt F:DNA bindingsq~ZqtjtF:single-stranded DNA bindingsq~ZttjtF:transcription factor activitysq~Z~tjtF:MutLalpha complex bindingsq~ZQtjtF:GMP synthase activitysq~Z|tjt*F:N-terminal myristoylation domain bindingsq~Ztjt$F:transcription corepressor activitysq~ZVtjtF:protein C-terminus bindingsq~ZOtjtF:endopeptidase activitysq~Z2tjtF:identical protein bindingsq~ZtjtF:calcium ion bindingsq~ZPtjt(F:structural constituent of cytoskeletonsq~ZNtjtF:structural molecule activitysq~ZtjtF:receptor bindingsq~ZtjtF:receptor activitysq~ZtjtF:epoxide hydrolase activitysq~Z tjt"F:glutathione transferase activitysq~Z tjt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZtjtF:serine-tRNA ligase activitysq~Ztjt C:nucleussq~Ztjt&C:proteasome complex (sensu Eukaryota)sq~Zitjt C:cytoplasmsq~ZtjtC:integral to plasma membranesq~ZktjtC:mitochondrionsq~ZttjtC:MHC class I protein complexsq~ZtjtC:plasma membranesq~Ztjt C:microtubulesq~Ztjt+C:proteasome core complex (sensu Eukaryota)sq~ZtjtC:cytoskeletonsq~Ztjt C:centrosomesq~ZtjtC:paraspecklessq~Ztjt0C:eukaryotic translation initiation factor 3 ...sq~Ztjt"C:DNA replication factor C complexsq~ZutjtC:clathrin coatsq~Ztjt&C:alpha DNA polymerase:primase complexsq~ZtjtC:endoplasmic reticulum lumensq~Zytjt#C:cortical microtubule cytoskeletonppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxpsq~uq~ sq~tjt IPR007110tIg-likesq~tjt IPR013783t Ig-like_foldsq~tjt IPR003006tIg/MHCsq~tjt IPR003597t Ig_C1-setsq~tjt IPR011161tMHC_I-like_Ag-recogsq~tjt IPR001039t MHC_I_a_a1/a2sq~tjt IPR010579t MHC_I_a_Cpppxsq~uq~ sq~tjtC1-settPF07654sq~tjtMHC_ItPF00129sq~tjtMHC_I_CtPF06623pppppppxtP30504t 1C04_HUMANsq~uq~ sq~tjtMHC class I antigen Cw*4pppppppppxt Homo sapienstT22D4sq~P?uPP(0(%tTSC22 domain family protein 4sq~uq~ sq~U0tENSG00000166925pppppppppxsq~uq~ sq~m0tTSC22D4sq~m0tTILZ2ppppppppxsq~Quq~ sq~ZO0t0P:regulation of cyclin-dependent protein kina...sq~Z0t/P:transcription from RNA polymerase II promotersq~Z0tP:metabolic processsq~Z [0tP:cell proliferationsq~Z0t%P:phosphoinositide-mediated signalingsq~Z0t!P:regulation of exit from mitosissq~Z0tP:mitotic cell cycle checkpointsq~Z0tP:regulation of mitosissq~Z0t%P:mitotic metaphase plate congressionsq~Z0t%P:spindle organization and biogenesissq~Zb0t*P:cytoskeleton organization and biogenesissq~ZC0tP:response to oxidative stresssq~Z0t(P:ER to Golgi vesicle-mediated transportsq~Z0t!P:cellular copper ion homeostasissq~Zo0t/P:ubiquitin-dependent protein catabolic processsq~Z0tP:neuron adhesionsq~Z-0t0P:acetylcholine receptor signaling, muscarini...sq~Z0tP:axon guidancesq~Z>0tP:mRNA metabolic processsq~Z>F0tP:formate metabolic processsq~Z&0tP:organ morphogenesissq~Z&>0tP:embryonic developmentsq~Z!0t0P:DNA damage response, signal transduction re...sq~Zuw0t0P:regulation of mitotic metaphase/anaphase tr...sq~Z0t)P:positive regulation of neuron apoptosissq~Z0tP:visual perceptionsq~Z0tP:brain developmentsq~Z`0t&P:regulation of neuron differentiationsq~Z0tP:axonal fasciculationsq~Z90tP:protein foldingsq~Z0t$P:DNA fragmentation during apoptosissq~Z0tP:neuron migrationsq~Z0t0P:ionotropic glutamate receptor signaling pat...sq~ZP0t P:G1 phase of mitotic cell cyclesq~Z 0tF:protein bindingsq~Z0t F:RNA bindingsq~Z0tF:actin bindingsq~Z0t0F:protein serine/threonine kinase activator a...sq~Z10t&F:diamine N-acetyltransferase activitysq~Z#_0tF:electron carrier activitysq~Z0tF:catalytic activitysq~Z?0tF:kinase activitysq~Zq0tF:single-stranded DNA bindingsq~Z0tF:cadherin bindingsq~Zv@0t0F:5-formyltetrahydrofolate cyclo-ligase activitysq~Zw30tF:snoRNA bindingsq~Z@0tF:protein kinase activitysq~Z30t#F:protein homodimerization activitysq~Z@0t0F:cyclin-dependent protein kinase 5 activator...sq~Z N0tF:zinc ion bindingsq~Z0t#F:ubiquitin-protein ligase activitysq~ZQ0tF:microtubule bindingsq~Z0tF:receptor bindingsq~Z0tF:copper ion bindingsq~Z0tF:calcium ion bindingsq~Z0t C:nucleussq~Zi0t C:cytoplasmsq~ZA0t C:lipid raftsq~Z{j0tC:neuromuscular junctionsq~Z0tC:endoplasmic reticulumsq~Z0tC:Golgi apparatussq~Z0t C:cell somasq~Z0tC:dendritic spinesq~Z= 0tC:actin cytoskeletonsq~Z0t C:polysomesq~Z0t&C:proteasome complex (sensu Eukaryota)sq~Z0t0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z0t C:cytosolsq~Zv0t C:growth conesq~Z00tC:endomembrane systemsq~Z=0tC:microtubule cytoskeletonsq~Zk0tC:mitochondrionsq~Z>0t C:membranesq~Z0tC:intracellularsq~Z@0t0C:cyclin-dependent protein kinase 5 activator...sq~Z00tC:anaphase-promoting complexsq~ZM0tC:extrinsic to membranesq~Z0t C:kinetochoresq~Zd0t+C:small nucleolar ribonucleoprotein complexsq~Zv0tC:axonsq~Z0tC:contractile fiberpppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~0t,P:regulation of transcription, DNA-dependentt6355sq~0tF:protein bindingt5515sq~0t"F:transcription repressor activityt16564pppppppxsq~uq~ sq~0t IPR000580tTSC-22_Dip_Bunpppppppppxsq~uq~ sq~0tTSC22tPF01166pppppppppxtQ9Y3Q8t T22D4_HUMANsq~uq~ sq~0t0TSC22-related-inducible leucine zipper protein 2sq~0tTsc-22-like protein THG-1ppppppppxt Homo sapienstTNIKsq~P?sW!<,`d `%t(TRAF2 and NCK-interacting protein kinasesq~uq~ sq~Ud tENSG00000154310pppppppppxsq~uq~ sq~md tTNIKsq~md tKIAA0551ppppppppxsq~uq~ @sq~Z [d tP:cell proliferationsq~Z d t P:translationsq~Zd tP:signal transductionsq~Zd tP:induction of apoptosissq~Z=d tP:protein complex assemblysq~Zdd tP:synaptic transmissionsq~Ztd tP:DNA replicationsq~Z>d tP:mRNA metabolic processsq~ZJd t.P:regulation of progression through cell cyclesq~ZFd tP:actin filament severingsq~ZOd t P:protein amino acid methylationsq~Z.d t(P:regulation of translational initiationsq~Z9d tP:protein foldingsq~Zd tP:lipid metabolic processsq~Zd t0P:retrograde vesicle-mediated transport, Golg...sq~Zd tP:cell motilitysq~Zd t P:chemotaxissq~Z&d tP:response to stresssq~Zd tP:nucleocytoplasmic transportsq~Zd t(P:intra-Golgi vesicle-mediated transportsq~Z+d tP:immune responsesq~Z,d tP:complement activationsq~Zd tP:female pregnancysq~Zkd t&P:multicellular organismal developmentsq~ZYd tP:activation of JNK activitysq~ZRd t)P:activation of NF-kappaB-inducing kinasesq~Zd t0P:G-protein coupled receptor protein signalin...sq~Zd t0P:cell surface receptor linked signal transdu...sq~Zd tP:mitotic cell cycle checkpointsq~Znd t%P:chaperonin-mediated tubulin foldingsq~Zid tP:microtubule-based processsq~Zd t P:transportsq~Z'd t"P:cholesterol biosynthetic processsq~Zd tP:signal complex assemblysq~Zd tP:nucleosome assemblysq~Zd tP:nucleosome disassemblysq~Zd t0P:regulation of transcription from RNA polyme...sq~Zd t0P:regulation of transcription from RNA polyme...sq~Zd t+P:transcription from mitochondrial promotersq~Zod t/P:ubiquitin-dependent protein catabolic processsq~ZDd t$P:protein amino acid phosphorylationsq~ZFd t&P:protein amino acid dephosphorylationsq~Zd tP:aspartate catabolic processsq~Zd tP:DNA recombinationsq~Zd t$P:DNA fragmentation during apoptosissq~Zd t P:DNA repairsq~Zd tP:ceramide metabolic processsq~Zd tP:fatty acid beta-oxidationsq~Zud tP:DNA-dependent DNA replicationsq~Zd t#P:snRNP protein import into nucleussq~Zd tP:L-serine biosynthetic processsq~Zd t P:glycolysissq~Zd t0P:nucleobase, nucleoside, nucleotide and nucl...sq~ZWd tP:dTMP biosynthetic processsq~Zd tP:regulation of DNA replicationsq~Znd tP:ATP-dependent proteolysissq~Zd tP:visual perceptionsq~Zd t0P:ribosomal small subunit assembly and mainte...sq~ZDd t0P:negative regulation of transcription, DNA-d...sq~Zd t0P:negative regulation of progression through ...sq~Zd tP:regulation of angiogenesissq~Zd t$P:regulation of cell differentiationsq~Zd tP:regulation of transcriptionsq~Zd tP:cellular respirationsq~Z0d t0P:intermediate filament cytoskeleton organiza...sq~Z#d t0P:positive regulation of tyrosine phosphoryla...sq~ZJd t+P:N-terminal protein amino acid acetylationsq~Zd t0P:negative regulation of tyrosine phosphoryla...sq~ZEd t0P:positive regulation of transcription, DNA-d...sq~Zd t(P:protein amino acid autophosphorylationsq~ZPd t P:G1 phase of mitotic cell cyclesq~Z;d tP:protein oligomerizationsq~Zd tP:inactivation of MAPK activitysq~Zd t(P:nuclear mRNA splicing, via spliceosomesq~ZId t!P:actin filament bundle formationsq~Zd t P:cytokinesissq~Zd tP:skeletal developmentsq~Z d t0P:positive regulation of T cell cytokine prod...sq~ZHd t#P:barbed-end actin filament cappingsq~Zƶd t*P:positive regulation of T cell activationsq~Zvd t-P:positive regulation of T cell proliferationsq~Zd t,P:negative regulation of histone acetylationsq~Zxvd t0P:positive regulation of actin filament polym...sq~Z%d tP:response to hormone stimulussq~Z$d t0P:pyrimidine ribonucleotide biosynthetic processsq~Z#d t)P:lipopolysaccharide biosynthetic processsq~Z!d t%P:caspase activation via cytochrome csq~Z'1d tP:response to organic substancesq~Z d tP:RNA splicingsq~Z \d t+P:positive regulation of cell proliferationsq~Zd t.P:actin polymerization and/or depolymerizationsq~Zad tP:tRNA processingsq~ZGgd t0P:protein amino acid N-linked glycosylation v...sq~Zvdd t$P:negative regulation of cell growthsq~Zv d tP:erythrocyte differentiationsq~Zud tP:regulation of cell adhesionsq~Zud t.P:regulation of Wnt receptor signaling pathwaysq~Zud tP:protein repairsq~ZuYd tP:actin filament polymerizationsq~ZMd t%P:second-messenger-mediated signalingsq~Zwd tP:maturation of SSU-rRNAsq~Z.d tF:protein bindingsq~Zd t F:RNA bindingsq~ZPd t(F:structural constituent of cytoskeletonsq~Z2d tF:identical protein bindingsq~Zd tF:receptor bindingsq~ZNJd tF:unfolded protein bindingsq~Z!d t0F:protein phosphatase type 2A regulator activitysq~ZAd tF:ATPase activitysq~Zd tF:calcium ion bindingsq~ZTd tF:GTPase activitysq~Zd t$F:structural constituent of ribosomesq~Zd t/F:ribonucleoside-diphosphate reductase activitysq~Zod t0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~Zld t0F:receptor signaling protein tyrosine kinase ...sq~Zjd t0F:transmembrane receptor protein tyrosine kin...sq~Zud t.F:receptor signaling complex scaffold activitysq~Zcd tF:MAP kinase activitysq~Zbd t#F:JUN kinase kinase kinase activitysq~ZVd t0F:eukaryotic translation initiation factor 2a...sq~ZNEd tF:heme bindingsq~Zd tF:thymidylate synthase activitysq~Zd t F:histidine-tRNA ligase activitysq~Z"Md t0F:N-acylneuraminate cytidylyltransferase acti...sq~Zd tF:signal transducer activitysq~Zd t(F:protein phosphatase inhibitor activitysq~Zd t"F:phospholipase inhibitor activitysq~Zd tF:enzyme inhibitor activitysq~Z>d tF:cyclosporin A bindingsq~Zd tF:uridine kinase activitysq~Zd tF:serine-tRNA ligase activitysq~Zd t0F:methylenetetrahydrofolate dehydrogenase act...sq~Z|d t*F:N-terminal myristoylation domain bindingsq~Z}d t0F:methenyltetrahydrofolate cyclohydrolase act...sq~Zd t)F:acetyl-CoA C-acetyltransferase activitysq~Zbd tF:IMP dehydrogenase activitysq~Zd tF:antigen bindingsq~Zd t$F:transcription corepressor activitysq~Zd t%F:protein heterodimerization activitysq~Zd t)F:7-dehydrocholesterol reductase activitysq~Zvd t0F:RNA polymerase II transcription factor acti...sq~Ztd tF:transcription factor activitysq~Zd tF:acid phosphatase activitysq~Zcd t0F:electron transporter, transferring electron...sq~ZWd t F:NAD bindingsq~Z d t0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~Zd tF:histone bindingsq~Zd t*F:formate-tetrahydrofolate ligase activitysq~Z}d t"F:ubiquitin thiolesterase activitysq~Zd t%F:carbonyl reductase (NADPH) activitysq~Z3d t#F:protein homodimerization activitysq~Zd t%F:ATP-dependent DNA helicase activitysq~Zqd tF:single-stranded DNA bindingsq~Zd tF:receptor activitysq~Zd t%F:GDP-dissociation inhibitor activitysq~Zd t F:ATP bindingsq~Zd tF:N-methyltransferase activitysq~Z Nd tF:zinc ion bindingsq~Zd tF:enoyl-CoA hydratase activitysq~Zd t0F:translation factor activity, nucleic acid b...sq~Zd tF:FK506 bindingsq~ZNd tF:structural molecule activitysq~Zd tF:actin bindingsq~Zd tF:Notch bindingsq~Z!#d tF:transaminase activitysq~Z!Xd tF:Ran GTPase bindingsq~Zd tF:cytoskeletal adaptor activitysq~Zid t C:cytoplasmsq~Z d t C:nucleussq~Zkd tC:mitochondrionsq~Zd t&C:proteasome complex (sensu Eukaryota)sq~Zd t C:cytosolsq~Zd tC:soluble fractionsq~Zd tC:integral to plasma membranesq~Zd tC:endoplasmic reticulumsq~Z= d tC:actin cytoskeletonsq~Z>d t C:membranesq~Zd t%C:protein phosphatase type 2A complexsq~Zbd t C:nucleolussq~Zd t0C:proteasome regulatory particle (sensu Eukar...sq~Zd tC:plasma membranesq~Zd t C:centrosomesq~Zd t C:polysomesq~Zd t(C:NuA4 histone acetyltransferase complexsq~ZWd t!C:perinuclear region of cytoplasmsq~Zd tC:Arp2/3 protein complexsq~Zd tC:neurofilamentsq~ZSd t.C:ribonucleoside-diphosphate reductase complexsq~Zd t&C:cytosolic ribosome (sensu Eukaryota)sq~Zd t0C:eukaryotic translation initiation factor 3 ...sq~Zd t C:kinetochoresq~Zd t0C:cytosolic small ribosomal subunit (sensu Eu...sq~Zd t'C:mitochondrial small ribosomal subunitsq~Z :d t$C:oligosaccharyl transferase complexsq~Z=d tC:microtubule cytoskeletonsq~Zd t C:spectrinsq~Zud tC:COPI vesicle coatsq~Zd tC:extracellular regionsq~Zd tC:extracellular spacesq~Zd tC:intracellularsq~Zd tC:membrane fractionsq~Zvd tC:axonsq~ZwAd tC:ribonucleoprotein complexsq~Zd tC:nuclear outer membranesq~Zd t C:microtubulesq~Z#d tC:transcription factor complexsq~Z1d t C:spliceosomesq~Z6d t C:snRNP U2sq~Z~d t#C:mitochondrial intermembrane spacesq~Z'd tC:cell surfaceppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~d t P:JNK cascadet7254sq~d t$P:protein amino acid phosphorylationt6468sq~d tP:response to stresst6950sq~d t F:ATP bindingt5524sq~d t*F:protein serine/threonine kinase activityt4674pppppxsq~uq~ sq~d t IPR001180tCitronsq~d t IPR000719tProt_kinase_coresq~d t IPR008271tSer_thr_pkin_ASsq~d t IPR002290tSer_thr_pkinaseppppppxsq~uq~ sq~d tCNHtPF00780sq~d tPkinasetPF00069ppppppppxtQ9UKE5t TNIK_HUMANpt Homo sapienstK1C15sq~P?~Ki:0:%tKeratin, type I cytoskeletal 15sq~uq~ sq~U0tENSG00000171346pppppppppxsq~uq~ sq~m0tKRT15sq~m0tKRTBppppppppxsq~Suq~ sq~ZF0t#P:peptidyl-tyrosine phosphorylationsq~Z0tP:ectoderm developmentsq~ZJ0t.P:regulation of progression through cell cyclesq~Z0t.P:actin polymerization and/or depolymerizationsq~Z \0t+P:positive regulation of cell proliferationsq~Z ]0t+P:negative regulation of cell proliferationsq~Z 0tP:RNA splicingsq~Z!0t0P:determination of anterior/posterior axis, e...sq~Z%0t$P:anatomical structure morphogenesissq~Z0tP:visual perceptionsq~Z0tP:signal transductionsq~Zl0tP:microtubule nucleationsq~Z0t,P:regulation of transcription, DNA-dependentsq~Z0t0P:regulation of transcription from RNA polyme...sq~Z0t/P:transcription from RNA polymerase II promotersq~Z=0tP:protein complex assemblysq~Zo0t/P:ubiquitin-dependent protein catabolic processsq~Zp0tP:ubiquitin cyclesq~Z&0tP:organ morphogenesissq~Zb0t*P:cytoskeleton organization and biogenesissq~Z:0t"P:negative regulation of apoptosissq~Z50t$P:intermediate filament organizationsq~Z0tP:regulation of cell growthsq~Z0t0P:positive regulation of gene-specific transc...sq~Z0t0P:proteasomal ubiquitin-dependent protein cat...sq~Z=0t.P:negative regulation of programmed cell deathsq~Z0t0P:chromatin-mediated maintenance of transcrip...sq~Z0t0P:microtubule cytoskeleton organization and b...sq~Z0tP:transcriptionsq~Z0t0P:Golgi to plasma membrane CFTR protein trans...sq~Zw60t,P:steroid hormone receptor signaling pathwaysq~Zv~0tP:regulation of cell migrationsq~Zu0tP:cell differentiationsq~ZB0t P:embryonic skeletal developmentsq~Z@]0tP:cell migrationsq~Z0tP:sarcomere organizationsq~Z0tF:protein bindingsq~ZP0t(F:structural constituent of cytoskeletonsq~Z0t$F:transcription coactivator activitysq~Z0t F:RNA bindingsq~Z]0t F:DNA bindingsq~Z0tF:actin bindingsq~Zw30tF:snoRNA bindingsq~Zu0tF:PDZ domain bindingsq~ZN0tF:structural molecule activitysq~ZA0tF:hydrolase activitysq~ZA0tF:ATPase activitysq~ZB0tF:SH3 domain bindingsq~Z0tF:SH3/SH2 adaptor activitysq~Ze0t&F:cysteine-type endopeptidase activitysq~Z s0t"F:structural constituent of musclesq~Z{+0t0F:thyrotropin-releasing hormone receptor bindingsq~Zj0tF:double-stranded DNA bindingsq~Zt0tF:transcription factor activitysq~Z0tF:cytoskeletal adaptor activitysq~ZM0tF:kinase bindingsq~Z N0tF:zinc ion bindingsq~Z0t!F:transcription cofactor activitysq~Z0t$F:transcription corepressor activitysq~Z0tF:protein complex scaffoldsq~Z}0t"F:ubiquitin thiolesterase activitysq~Z 0t C:nucleussq~Zi0t C:cytoplasmsq~Z0tC:intermediate filamentsq~Z'0tC:keratin filamentsq~Z0t&C:proteasome complex (sensu Eukaryota)sq~ZuK0tC:lamellipodiumsq~Z{0tC:apical cortexsq~Z0tC:spindle polesq~Z0tC:pericentriolar materialsq~Z0t C:polysomesq~Z0t C:cytosolsq~Z0tC:microtubule organizing centersq~Z R0tC:gamma-tubulin ring complexsq~Zk0tC:mitochondrionsq~Z0t C:centrosomesq~Zd0t+C:small nucleolar ribonucleoprotein complexsq~Z0t C:nucleoplasmsq~Z0tC:intracellularsq~Z@0tC:chromatin remodeling complexsq~Zu0t C:filopodiumsq~Z= 0tC:actin cytoskeletonsq~Z0t C:costamerepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~0tP:epidermis developmentt8544sq~0tF:protein bindingt5515sq~0t(F:structural constituent of cytoskeletont5200sq~0tC:intermediate filamentt5882ppppppxsq~uq~ sq~0t IPR001664tIFsq~0t IPR002957t Keratin_Ippppppppxsq~uq~ sq~0tFilamenttPF00038pppppppppxtP19012t K1C15_HUMANsq~uq~ sq~0tCytokeratin-15sq~0tCK-15sq~0t Keratin-15sq~0tK15ppppppxt Homo sapienstCRYABsq~P?U%tAlpha-crystallin B chainsq~uq~ sq~UUtENSG00000109846pppppppppxsq~uq~ sq~mUtCRYABsq~mUtCRYA2ppppppppxsq~Huq~ Psq~ZUtP:signal transductionsq~ZUtP:visual perceptionsq~ZUtP:anti-apoptosissq~ZUtP:cell motilitysq~ZJUtP:response to unfolded proteinsq~ZOUt P:circulationsq~Z!Ut0P:negative regulation of survival gene produc...sq~ZUtP:axonogenesissq~Z Ut0P:transmembrane receptor protein serine/threo...sq~ZWUt P:carbohydrate metabolic processsq~Z.Ut(P:regulation of translational initiationsq~ZJUt.P:regulation of progression through cell cyclesq~ZUtP:mitochondrial transportsq~ZUt!P:cellular copper ion homeostasissq~ZUtP:striated muscle contractionsq~ZUtP:cell cycle arrestsq~ZuTUt0P:actin cytoskeleton organization and biogenesissq~ZvUtP:myofibril assemblysq~ZvdUt$P:negative regulation of cell growthsq~ZUtP:neuromuscular processsq~ZHUt0P:negative regulation of thymidylate synthase...sq~Z6Ut0P:regulation of mitochondrial membrane permea...sq~Z,Ut+P:release of cytochrome c from mitochondriasq~ZUt(P:protein amino acid autophosphorylationsq~ZUt0P:negative regulation of S phase of mitotic c...sq~ZUtP:regulation of transcriptionsq~ZuUt0P:positive regulation of nitric oxide biosynt...sq~Z9UtP:protein foldingsq~ZUt"P:regulation of cell proliferationsq~Z*UtP:protein refoldingsq~Z~Ut0P:negative regulation of intracellular transportsq~ZʩUt0P:regulation of mitochondrial membrane potentialsq~ZUt P:mitosissq~ZUtF:protein bindingsq~Z2UtF:identical protein bindingsq~ZUtF:transcription factor bindingsq~ZPUt(F:structural constituent of cytoskeletonsq~ZUt F:ATP bindingsq~ZBUt*F:protein serine/threonine kinase activitysq~ZxUtF:TPR domain bindingsq~ZUtF:phosphatidylinositol bindingsq~ZvUt*F:nitric-oxide synthase regulator activitysq~ZUtF:calmodulin bindingsq~Z\Ut$F:structural constituent of eye lenssq~ZB~UtF:myosin bindingsq~Z3Ut#F:protein homodimerization activitysq~ZNUtF:structural molecule activitysq~Z sUt"F:structural constituent of musclesq~ZUt.F:serine-type endopeptidase inhibitor activitysq~Z Ut F:citrate (Si)-synthase activitysq~ZUtF:beta-amyloid bindingsq~ZUtF:alpha-actinin bindingsq~ZiUt C:cytoplasmsq~ZUtC:integral to plasma membranesq~ZUtC:cytoskeletonsq~ZUt C:nucleussq~Z'UtC:cell surfacesq~ZUt C:spectrinsq~ZUt C:cytosolsq~ZUtC:extracellular regionsq~ZUtC:condensed nuclear chromosomesq~ZUt&C:proteasome complex (sensu Eukaryota)sq~ZUtC:plasma membranesq~ZUtC:mitochondrial matrixsq~ZmUtC:mitochondrial outer membranesq~ZUt C:synapsesq~ZUtC:protein complexsq~ZuBUtC:Z discsq~ZuKUtC:lamellipodiumsq~ZUt(C:NuA4 histone acetyltransferase complexsq~ZUtC:intracellularsq~ZvUt C:growth coneppppppppxsq~uq~ sq~UtP:anti-apoptosist6916sq~UtP:muscle contractiont6936sq~Ut0P:negative regulation of intracellular transportt32387sq~UtP:protein foldingt6457sq~Ut0P:transmembrane receptor protein tyrosine kin...t7169sq~UtF:protein bindingt5515sq~Ut C:cytoplasmt5737pppxsq~uq~ sq~Ut IPR011369tAlpha-crystallinsq~Ut IPR001436tAlpha-crystallin/HSPsq~Ut IPR012273tAlpha-crystallin_Bsq~Ut IPR003090tAlpha-crystallin_Nsq~Ut IPR002068tHsp20pppppxsq~uq~ sq~Ut CrystallintPF00525sq~UtHSP20tPF00011ppppppppxtP02511t CRYAB_HUMANsq~uq~ sq~UtAlpha(B)-crystallinsq~UtRosenthal fiber componentsq~UtHeat shock protein beta-5sq~UtHspB5sq~Ut!Renal carcinoma antigen NY-REN-27pppppxt Homo sapienstQ8WTW2sq~P%tN-myc (And STAT) interactorsq~uq~ sq~UtENSG00000123609pppppppppxsq~uq~ sq~mtNMIpppppppppxsq~uq~ (sq~ZZt)P:negative regulation of JAK-STAT cascadesq~Zt0P:transcription initiation from RNA polymeras...sq~Zt/P:transcription from RNA polymerase II promotersq~Zt P:endocytosissq~ZitP:microtubule-based processsq~ZtP:cell adhesionsq~Z ]t+P:negative regulation of cell proliferationsq~Z?EtP:endosome transportsq~ZtP:glycine catabolic processsq~ZtF:protein bindingsq~Zt F:GTP bindingsq~Zt!F:aminomethyltransferase activitysq~Zt F:RNA bindingsq~ZttF:transcription factor activitysq~Zt C:nucleussq~ZutC:clathrin vesicle coatsq~ZHtC:glycine cleavage complexsq~Zt C:coated pitsq~Zt C:microtubulesq~Zt C:polysomesq~ZtC:early endosomesq~ZktC:mitochondrionsq~Zt&C:proteasome complex (sensu Eukaryota)pppppppppppppppppxpsq~uq~ sq~t IPR009938tIFP_35_Nsq~t IPR009909t Nmi/IFP35ppppppppxsq~uq~ sq~tIFP_35_NtPF07334sq~tNIDtPF07292ppppppppxtQ8WTW2t Q8WTW2_HUMANpt Homo sapienstARP6sq~P?NR%tActin-related protein 6sq~uq~ sq~UtENSG00000075089pppppppppxsq~uq~ sq~mtACTR6sq~mtCDA12ppppppppxsq~.uq~ Psq~ZtP:signal transductionsq~Zt0P:regulation of transcription from RNA polyme...sq~ZtP:translational elongationsq~ZIt!P:actin filament bundle formationsq~Z [tP:cell proliferationsq~Z]tP:muscle developmentsq~ZstP:spermatogenesissq~ZtP:DNA methylationsq~Z t P:translationsq~ZtP:chromatin remodelingsq~Z>tP:mRNA metabolic processsq~Z@at&P:negative regulation of transcriptionsq~ZEt0P:positive regulation of transcription, DNA-d...sq~Z tP:B cell lineage commitmentsq~Zwt0P:chromatin silencing at silent mating-type c...sq~Z tF:protein bindingsq~Zt F:RNA bindingsq~ZbtF:chromatin bindingsq~Zt(F:translation elongation factor activitysq~ZKtF:nucleoside kinase activitysq~Z3t#F:protein homodimerization activitysq~Z@t"F:transcription repressor activitysq~Zt%F:protein heterodimerization activitysq~ZqtF:single-stranded DNA bindingsq~Z~t)F:methionine adenosyltransferase activitysq~ZtF:adenylate kinase activitysq~ZttF:transcription factor activitysq~ZtF:transketolase activitysq~Zt)F:Rab GDP-dissociation inhibitor activitysq~Zt F:GTP bindingsq~Z^tF:DNA helicase activitysq~ZTtF:GTPase activitysq~Zt$F:structural constituent of ribosomesq~Zt C:nucleussq~Zit C:cytoplasmsq~Zt(C:NuA4 histone acetyltransferase complexsq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zt0C:eukaryotic translation elongation factor 1 ...sq~ZtC:nuclear chromatinsq~ZtC:plasma membranesq~Z'tC:cell surfacesq~Zbt C:nucleolussq~Z.tC:chromatin assembly complexsq~Zt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Zt C:polysomesq~Z= tC:actin cytoskeletonppppppppppppppppppppppppppppppppppxpsq~uq~ sq~t IPR004000t Actin_likepppppppppxsq~uq~ sq~tActintPF00022pppppppppxtQ9GZN1t ARP6_HUMANsq~uq~ sq~thArp6sq~thARPXppppppppxt Homo sapienstADRM1sq~P?xxxxxuc%t Protein ADRM1sq~uq~ sq~UctENSG00000130706pppppppppxsq~uq~ sq~mctADRM1sq~mctGP110ppppppppxsq~uq~ (sq~Z [ctP:cell proliferationsq~ZctP:cell cycle arrestsq~ZctP:nervous system developmentsq~ZJct!P:intracellular signaling cascadesq~ZctP:signal transductionsq~ZctP:mitotic cell cycle checkpointsq~Zct$P:protein targeting to mitochondrionsq~Zoct/P:ubiquitin-dependent protein catabolic processsq~Z=ctP:glucose transportsq~ZctP:sensory perception of soundsq~ZctP:skeletal developmentsq~Z ctF:protein bindingsq~ZMctF:kinase bindingsq~Zct F:RNA bindingsq~ZOctF:endopeptidase activitysq~Z NctF:zinc ion bindingsq~Z ct!F:growth hormone receptor bindingsq~Z;ctF:hormone activitysq~ZMctF:enzyme bindingsq~Zct&C:proteasome complex (sensu Eukaryota)sq~Zct0C:proteasome regulatory particle (sensu Eukar...sq~Zct+C:proteasome core complex (sensu Eukaryota)sq~Zpct0C:mitochondrial inner membrane presequence tr...sq~Zct C:kinetochoresq~ZctC:protein complexsq~ZWct!C:perinuclear region of cytoplasmppppppppppppppxsq~uq~ sq~ctP:proteasome assemblyt43248sq~ct0P:RNA elongation from RNA polymerase II promotert6368sq~ctF:proteasome activator activityt8538sq~ctC:integral to plasma membranet5887sq~ctC:membrane fractiont5624sq~ct&C:proteasome complex (sensu Eukaryota)t502ppppxsq~uq~ sq~ct IPR006773tARM_1pppppppppxsq~uq~ sq~ctARM_1tPF04683pppppppppxtQ16186t ADRM1_HUMANsq~uq~ sq~ctAdhesion-regulating molecule 1sq~ct"110 kDa cell membrane glycoproteinsq~ctGp110sq~ct,Proteasome regulatory particle non-ATPase 13sq~cthRpn13pppppxt Homo sapienstHHEXsq~P?qq 2 %tHomeobox protein PRHsq~uq~ sq~U2tENSG00000152804pppppppppxsq~uq~ sq~m2tHHEXsq~m2tHEXsq~m2tPRHsq~m2tPRHXppppppxsq~uq~ (sq~Z2t0P:regulation of transcription from RNA polyme...sq~Z@a2t&P:negative regulation of transcriptionsq~Z2t/P:transcription from RNA polymerase II promotersq~Z=2tP:protein complex assemblysq~ZA2t0P:DNA damage response, signal transduction by...sq~Z2t$P:central nervous system developmentsq~Z]2tP:muscle developmentsq~Z%2t$P:anatomical structure morphogenesissq~Z&2tP:organ morphogenesissq~Z@2t%P:negative regulation of angiogenesissq~Zu2t0P:negative regulation of Wnt receptor signali...sq~Zvd2t$P:negative regulation of cell growthsq~Z2t0P:DNA damage response, signal transduction by...sq~ZN2t%P:positive regulation of phagocytosissq~Z2t,P:regulation of transcription, DNA-dependentsq~Z2tP:response to hypoxiasq~Z2tF:protein bindingsq~Zt2tF:transcription factor activitysq~Zv2t0F:RNA polymerase II transcription factor acti...sq~Z2t$F:transcription coactivator activitysq~ZQ2t-F:extracellular matrix structural constituentsq~Z2tF:transcription factor bindingsq~Z2t C:nucleussq~Z2tC:basement membranesq~Z2tC:insoluble fractionsq~Z@2t C:PML bodysq~Zb2t C:nucleolussq~Zi2t C:cytoplasmsq~Z2t&C:proteasome complex (sensu Eukaryota)sq~Z2tC:nuclear chromosomeppppppppppxsq~uq~ sq~2t&P:multicellular organismal developmentt7275sq~2tF:protein bindingt5515sq~2tF:transcription factor activityt3700pppppppxsq~uq~ sq~2t IPR001356tHomeoboxsq~2t IPR012287tHomeodomain-relsq~2t IPR000047tHTH_lambrepressrpppppppxsq~uq~ sq~2tHomeoboxtPF00046pppppppppxtQ03014t HHEX_HUMANsq~uq~ sq~2t$Hematopoietically-expressed homeoboxsq~2tHomeobox protein HEXppppppppxt Homo sapienstPRS4sq~P?%gM%t!26S protease regulatory subunit 4sq~uq~ sq~UMtENSG00000100764pppppppppxsq~uq~ sq~mMtPSMC1pppppppppxsq~)uq~ Psq~ZƶMt*P:positive regulation of T cell activationsq~ZMt,P:regulation of transcription, DNA-dependentsq~ZDMt$P:protein amino acid phosphorylationsq~ZlMt P:proteolysissq~ZnMtP:ATP-dependent proteolysissq~ZMtP:anti-apoptosissq~ZMtP:caspase activationsq~ZUMt%P:nuclear organization and biogenesissq~ZMtP:signal transductionsq~ZRMt)P:activation of NF-kappaB-inducing kinasesq~ZVMt P:JNK cascadesq~ZMtP:visual perceptionsq~Z@MtP:protein ubiquitinationsq~ZvMt)P:ER-associated protein catabolic processsq~ZxMtP:unfolded protein responsesq~ZsMt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZƤMt#P:T cell receptor signaling pathwaysq~ZMtP:double-strand break repairsq~ZMtP:protein polyubiquitinationsq~Z Mt0P:positive regulation of T cell cytokine prod...sq~Z&MtP:response to stresssq~ZxMt-P:retrograde protein transport, ER to cytosolsq~ZMtF:protein bindingsq~ZAMtF:ATPase activitysq~ZMt F:ATP bindingsq~ZMt#F:ubiquitin-protein ligase activitysq~ZMt$F:transcription coactivator activitysq~ZtMtF:transcription factor activitysq~ZMtF:signal transducer activitysq~ZMt!F:transmembrane receptor activitysq~ZBMt*F:protein serine/threonine kinase activitysq~ZMt&C:proteasome complex (sensu Eukaryota)sq~ZMt0C:proteasome regulatory particle (sensu Eukar...sq~ZMt C:nucleussq~ZiMt C:cytoplasmsq~ZMt C:cytosolsq~ZMtC:autophagic vacuolesq~ZMtC:Bcl3/NF-kappaB2 complexsq~ZMtC:protein complexsq~ZMt C:microsomesq~ZMtC:endoplasmic reticulumpppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~MtF:ATPase activityt16887sq~MtF:protein bindingt5515sq~Mt&C:proteasome complex (sensu Eukaryota)t502pppppppxsq~uq~ sq~Mt IPR005937t26S_proteasome_P45sq~Mt IPR003593tAAA+_ATPase_coresq~Mt IPR003959tAAA_ATPase_coresq~Mt IPR003960tAAA_ATPase_subppppppxsq~uq~ sq~MtAAAtPF00004pppppppppxtP62191t PRS4_HUMANsq~uq~ sq~MtP26s4sq~MtProteasome 26S subunit ATPase 1ppppppppxt Homo sapienstHIF1Asq~P?,,%t Hypoxia-inducible factor 1 alphasq~uq~ sq~UtENSG00000100644pppppppppxsq~uq~ sq~mtHIF1Asq~mtMOP1ppppppppxsq~uq~ sq~ZtP:signal transductionsq~ZJt.P:regulation of progression through cell cyclesq~Z ]t+P:negative regulation of cell proliferationsq~ZtP:response to hypoxiasq~Zt/P:transcription from RNA polymerase II promotersq~Zt,P:regulation of transcription, DNA-dependentsq~ZFt(P:N-terminal peptidyl-lysine acetylationsq~ZtP:nervous system developmentsq~Z@tP:protein ubiquitinationsq~ZtP:cell cycle arrestsq~Z [tP:cell proliferationsq~ZtP:base-excision repairsq~Z`tP:homeostatic processsq~ZtP:transcription, DNA-dependentsq~ZtP:anti-apoptosissq~ZDt$P:protein amino acid phosphorylationsq~Z=tP:protein complex assemblysq~Zut&P:positive regulation of transcriptionsq~Zzt0P:negative regulation of transcription from R...sq~ZtP:protein localizationsq~ZtP:mitochondrial transportsq~Z!t0P:induction of apoptosis by extracellular sig...sq~Zt P:apoptosissq~ZtP:circadian rhythmsq~Zt P:cell agingsq~ZJtP:response to unfolded proteinsq~Z|tP:sex differentiationsq~Zt$P:central nervous system developmentsq~Z&tP:response to stresssq~ZstP:spermatogenesissq~Zkt&P:multicellular organismal developmentsq~ZGtP:ER overload responsesq~ZctP:cell-cell signalingsq~Zt P:cell cyclesq~ZYt0P:chromosome organization and biogenesis (sen...sq~Z!t%P:caspase activation via cytochrome csq~Z$tP:response to light stimulussq~Zt0P:DNA damage response, signal transduction by...sq~Zut0P:positive regulation of nitric oxide biosynt...sq~Zt0P:positive regulation of protein catabolic pr...sq~Zt0P:positive regulation of global transcription...sq~ZEt0P:positive regulation of transcription, DNA-d...sq~Zxt0P:positive regulation of transcription from R...sq~Z6t0P:regulation of mitochondrial membrane permea...sq~ZƅtP:protein stabilizationsq~ZǓt0P:positive regulation of transcription factor...sq~ZǙt*P:negative regulation of helicase activitysq~ZǝtP:regulation of DNA bindingsq~Z>tP:protein tetramerizationsq~Zt)P:regulation of protein catabolic processsq~Zt)P:cellular response to glucose starvationsq~Z*tP:protein refoldingsq~Z%t P:entrainment of circadian clocksq~Z>t P:cell growthsq~Z?tP:phosphorylationsq~Z@at&P:negative regulation of transcriptionsq~Z@tP:chromatin modificationsq~Z@tP:histone acetylationsq~ZuOtP:cell projection biogenesissq~Zvdt$P:negative regulation of cell growthsq~Zw't&P:regulation of cell redox homeostasissq~Zw8t%P:estrogen receptor signaling pathwaysq~Zw9t%P:androgen receptor signaling pathwaysq~ZxtP:prostate gland developmentsq~Z[tP:protein heterooligomerizationsq~Zt P:transportsq~ZptP:ubiquitin cyclesq~ZtP:regulation of cell growthsq~ZtP:cell morphogenesissq~Zt-P:positive regulation of cell differentiationsq~ZtP:nucleotide-excision repairsq~ZtP:DNA packagingsq~ZtP:chromatin remodelingsq~Z t P:translationsq~ZJt+P:N-terminal protein amino acid acetylationsq~ZKt)P:internal protein amino acid acetylationsq~Zlt P:proteolysissq~Zt P:in utero embryonic developmentsq~Z tF:protein bindingsq~Zt tF:transcription factor activitysq~Z t$F:transcription coactivator activitysq~Zt F:ATP bindingsq~Z}tF:protein N-terminus bindingsq~ZMtF:enzyme bindingsq~Z3t#F:protein homodimerization activitysq~Zt0F:aryl hydrocarbon receptor nuclear transloca...sq~Zt%F:protein heterodimerization activitysq~Zt$F:transcription corepressor activitysq~Z2t$F:histone acetyltransferase activitysq~Z NtF:zinc ion bindingsq~ZtF:transcription factor bindingsq~Zvt0F:RNA polymerase II transcription factor acti...sq~ZVtF:protein C-terminus bindingsq~Z]t F:DNA bindingsq~ZxtF:TPR domain bindingsq~ZtF:nuclease activitysq~Zt F:endodeoxyribonuclease activitysq~ZtF:ribonuclease H activitysq~ZtF:phosphodiesterase I activitysq~Z t"F:phosphoglycerate kinase activitysq~Zvt*F:nitric-oxide synthase regulator activitysq~ZJtF:protein kinase CK2 activitysq~Z7tF:histone deacetylase activitysq~ZtF:DNA strand annealing activitysq~ZTtF:GTPase activitysq~Z-tF:sequence-specific DNA bindingsq~ZtF:metal ion bindingsq~ZJtF:histone deacetylase bindingsq~ZytF:MyoD bindingsq~Z2tF:identical protein bindingsq~ZtF:protein dimerization activitysq~Zt(F:translation initiation factor activitysq~ZtF:androgen receptor bindingsq~ZBt0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~ZMrtF:oxygen sensor activitysq~ZtF:N-acetyltransferase activitysq~ZtF:copper ion bindingsq~ZytF:androgen bindingsq~Z tF:ferrous iron bindingsq~Z@tF:acetyltransferase activitysq~ZtF:androgen receptor activitysq~Z@ktF:oxidoreductase activitysq~Z@t"F:transcription activator activitysq~ZtF:signal transducer activitysq~ZMKt+F:small conjugating protein ligase activitysq~ZctF:MAP kinase activitysq~ZC t0F:negative regulator of basal transcription a...sq~ZC t#F:aryl hydrocarbon receptor bindingsq~ZABt0F:oxidoreductase activity, acting on paired d...sq~Zt#F:ubiquitin-protein ligase activitysq~Zt#F:uracil DNA N-glycosylase activitysq~Z tF:3'-5' exonuclease activitysq~Zt C:nucleussq~Zit C:cytoplasmsq~Zt C:cytosolsq~ZtC:insoluble fractionsq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZWt!C:perinuclear region of cytoplasmsq~ZtC:endoplasmic reticulumsq~ZktC:mitochondrionsq~Zbt C:nucleolussq~Zt C:nucleoplasmsq~ZtC:stress fibersq~ZvtC:histone deacetylase complexsq~ZtC:nuclear chromosomesq~ZtC:soluble fractionsq~ZtC:plasma membranesq~Zt C:microtubulesq~Zt0C:eukaryotic translation initiation factor 3 ...sq~Z?tC:nuclear matrixsq~Zt C:ribosomesq~Z$tC:microtubule-based flagellumsq~Z#tC:transcription factor complexsq~ZtC:neuron projectionppppppxsq~uq~ sq~tP:homeostatic processt42592sq~t0P:positive regulation of transcription from R...t45944sq~tP:response to hypoxiat1666sq~tP:signal transductiont7165sq~t#F:histone acetyltransferase bindingt35035sq~t%F:protein heterodimerization activityt46982sq~t0F:RNA polymerase II transcription factor acti...t3705sq~tC:transcription factor complext5667ppxsq~uq~ sq~t IPR014887t HIF-1a_CTADsq~t IPR001092t HLH_basicsq~t IPR001321tHypoxindF1A_PASsq~t IPR001610tPACsq~t IPR000014tPASsq~t IPR013655tPAS_3ppppxsq~uq~ sq~t HIF-1a_CTADtPF08778sq~tHLHtPF00010sq~tPAS_3tPF08447pppppppxtQ16665t HIF1A_HUMANsq~uq~ sq~t HIF-1 alphasq~t HIF1 alphasq~tARNT-interacting proteinsq~tMember of PAS protein 1sq~t'Basic-helix-loop-helix-PAS protein MOP1pppppxt Homo sapienstCCR5sq~P?ii(&u)%tC-C chemokine receptor type 5sq~uq~ sq~U&utENSG00000160791sq~U&utENSG00000215778ppppppppxsq~uq~ sq~m&utCCR5sq~m&utCMKBR5ppppppppxsq~uq~ sq~Z &ut P:chemotaxissq~Z &utP:signal transductionsq~Z*&utP:inflammatory responsesq~ZD&ut$P:protein amino acid phosphorylationsq~Zc&utP:cell-cell signalingsq~Z&ut"P:cellular calcium ion homeostasissq~Z[&utP:JAK-STAT cascadesq~Z&utP:cell motilitysq~Z+&utP:immune responsesq~Z%&utP:response to virussq~Z&utP:cell adhesionsq~ZJ&ut.P:regulation of progression through cell cyclesq~Z&ut0P:negative regulation of adenylate cyclase ac...sq~Z&ut P:exocytosissq~Z8&utP:cellular defense responsesq~Z \&ut+P:positive regulation of cell proliferationsq~Z$&ut0P:elevation of cytosolic calcium ion concentr...sq~Z=&ut%P:integrin-mediated signaling pathwaysq~Z&ut0P:G-protein coupled receptor protein signalin...sq~Z=&utP:glutamate transportsq~ZJ&utP:viral genome replicationsq~ZK&ut0P:cytokine and chemokine mediated signaling p...sq~Z&utP:caspase activationsq~Z&ut P:apoptosissq~ZJ&ut!P:intracellular signaling cascadesq~ZQ&ut#P:I-kappaB kinase/NF-kappaB cascadesq~Z"&utP:phospholipase C activationsq~Z/&utP:humoral immune responsesq~Z&ut0P:G-protein signaling, coupled to cyclic nucl...sq~Z&ut0P:establishment and/or maintenance of cell po...sq~ZC&utP:response to oxidative stresssq~Z&utP:signal complex assemblysq~Z&utP:regulation of transcriptionsq~Zb&ut*P:cytoskeleton organization and biogenesissq~Z&ut0P:transmembrane receptor protein tyrosine kin...sq~Z\&ut*P:tyrosine phosphorylation of STAT proteinsq~Za&ut!P:Ras protein signal transductionsq~Z&utP:response to drugsq~Z9&ut"P:positive regulation of apoptosissq~Z&ut)P:blood vessel endothelial cell migrationsq~Z&utP:T cell selectionsq~Z &ut(P:regulation of viral genome replicationsq~Z&ut0P:positive regulation of interleukin-2 biosyn...sq~Z$&ut0P:positive regulation of protein kinase activitysq~Zi&utP:synaptic vesicle transportsq~ZƮ&ut0P:positive regulation of T cell receptor sign...sq~ZƯ&ut!P:regulation of T cell activationsq~Zƶ&ut*P:positive regulation of T cell activationsq~Z{,&ut#P:actin cytoskeleton reorganizationsq~Zv&utP:monocyte differentiationsq~Zv &utP:platelet formationsq~Z&utP:nervous system developmentsq~ZJ&utP:mesoderm developmentsq~Z&utP:response to nutrientsq~Z&utP:blood coagulationsq~Z ]&ut+P:negative regulation of cell proliferationsq~Z &utP:regulation of cell shapesq~Z$b&utP:response to radiationsq~Z&&utP:organ morphogenesissq~Z:&utP:protein transportsq~Zu`&utP:actin filament-based movementsq~Zv &utP:T cell differentiationsq~Z&utP:leukocyte migrationsq~Z)&utP:acute-phase responsesq~Z&ut0P:regulation of transcription from RNA polyme...sq~Z &ut0P:release of sequestered calcium ion into cyt...sq~ZV&ut'P:G2/M transition of mitotic cell cyclesq~Zz&ut0P:negative regulation of transcription from R...sq~Z&utP:activation of MAPK activitysq~Z&ut"P:conjugation with cellular fusionsq~Z&ut P:cytokinesissq~Z&utP:angiogenesissq~Z&ut/P:transcription from RNA polymerase II promotersq~Zm&ut)P:membrane protein ectodomain proteolysissq~Z&&utP:response to stresssq~Z&utP:muscle contractionsq~Z&utP:induction of apoptosissq~Z&utP:anti-apoptosissq~Z&ut P:endocytosissq~Z&utP:cellular zinc ion homeostasissq~Z&utP:calcium ion transportsq~Z&ut P:transportsq~ZI &utF:chemokine activitysq~Z &utF:protein bindingsq~Z&utF:signal transducer activitysq~ZT&utF:GTPase activitysq~Zi&ut"F:protein-tyrosine kinase activitysq~Z&utF:SH2 domain bindingsq~Z@&utF:protein kinase activitysq~ZH&utF:chemoattractant activitysq~Zt&utF:transcription factor activitysq~Z&ut0F:hematopoietin/interferon-class (D200-domain...sq~Z:&utF:coreceptor activitysq~ZM&utF:protein kinase bindingsq~Z3&ut#F:protein homodimerization activitysq~Z&utF:glycoprotein bindingsq~Zk&ut0F:non-membrane spanning protein tyrosine kina...sq~Zǭ&utF:ATPase bindingsq~ZG&utF:actin filament bindingsq~Z&utF:microfilament motor activitysq~Z&ut#F:phosphoinositide 3-kinase bindingsq~Z&utF:protein anchorsq~Z{&ut!F:CCR2 chemokine receptor bindingsq~Zq&utF:CD4 receptor bindingsq~Z}&utF:myosin light chain bindingsq~Zr&utF:CD8 receptor bindingsq~Z1&utF:MHC class II protein bindingsq~Z&utF:actin bindingsq~ZM&utF:enzyme bindingsq~Zl&ut0F:receptor signaling protein tyrosine kinase ...sq~Z&ut F:GTP bindingsq~ZQ&utF:microtubule bindingsq~ZV&utF:protein C-terminus bindingsq~Z&utF:transcription factor bindingsq~Z N&utF:zinc ion bindingsq~ZQ&ut-F:extracellular matrix structural constituentsq~Z&utF:receptor bindingsq~ZV&utF:chemokine receptor activitysq~Zr&ut/F:protein serine/threonine phosphatase activitysq~Z&ut!F:transmembrane receptor activitysq~Z&utF:enzyme inhibitor activitysq~ZA&utF:ATPase activitysq~Z@&ut"F:transcription activator activitysq~Z@n&ut#F:C-X-C chemokine receptor activitysq~Zi &ut C:cytoplasmsq~Z&utC:extracellular spacesq~Z&utC:soluble fractionsq~Z&utC:plasma membranesq~Z&ut C:nucleussq~Z&utC:integral to plasma membranesq~Z>&utC:integral to membranesq~Z&ut C:cytosolsq~Z&ut"C:heterotrimeric G-protein complexsq~Z&utC:pericentriolar materialsq~Z&utC:cytoskeletonsq~Z&ut&C:proteasome complex (sensu Eukaryota)sq~Z&utC:contractile ringsq~Z&utC:postsynaptic membranesq~Zz&utC:leading edgesq~Z}&utC:cleavage furrowsq~Zu&utC:T cell receptor complexsq~Z&utC:extracellular regionsq~Z&utC:rufflesq~Z&utC:membrane fractionsq~Z&utC:stress fibersq~ZA&ut C:lipid raftsq~Z&utC:protein complexpppppppppppppxsq~uq~ sq~&utP:inflammatory responset6954sq~&utP:immune responset6955sq~&ut0P:G-protein coupled receptor protein signalin...t7186sq~&ut0P:elevation of cytosolic calcium ion concentr...t7204sq~&ut P:chemotaxist6935sq~&utP:cellular defense responset6968sq~&utP:cell-cell signalingt7267sq~&ut+F:phosphoinositide phospholipase C activityt4435sq~&utF:coreceptor activityt15026sq~&ut!F:C-C chemokine receptor activityt16493sq~&utF:actin bindingt3779sq~&utC:integral to plasma membranet5887sq~&ut"C:external side of plasma membranet9897sq~&ut C:endosomet5768ppppppxsq~uq~ sq~&ut IPR002240t CC_5_rcptsq~&ut IPR000355t Chmkine_rcptsq~&ut IPR000276t GPCR_Rhodpsnpppppppxsq~uq~ sq~&ut7tm_1tPF00001pppppppppxtP51681t CCR5_HUMANsq~uq~ sq~&ut C-C CKR-5sq~&utCC-CKR-5sq~&utCCR-5sq~&utCCR5sq~&utHIV-1 fusion coreceptorsq~&utCHEMR13sq~&ut CD195 antigenpppxt Homo sapienstRIOK3sq~PP%t$Serine/threonine-protein kinase RIO3sq~uq~ sq~UPtENSG00000101782pppppppppxsq~uq~ sq~mPtRIOK3sq~mPtSUDDppppppppxsq~uq~ (sq~ZPtP:DNA recombinationsq~ZPt P:DNA repairsq~Z9PtP:protein foldingsq~ZlPt P:proteolysissq~ZPt!P:intracellular protein transportsq~ZPt0P:G-protein coupled receptor protein signalin...sq~ZPtP:rRNA processingsq~ZPtF:protein bindingsq~ZPtF:calcium ion bindingsq~ZAPtF:ATPase activitysq~Z|Pt*F:N-terminal myristoylation domain bindingsq~Z2PtF:identical protein bindingsq~ZoPtF:enzyme activator activitysq~ZNJPtF:unfolded protein bindingsq~ZPt F:RNA bindingsq~ZTPtF:GTPase activitysq~ZPt%F:ATP-dependent DNA helicase activitysq~ZPt&C:proteasome complex (sensu Eukaryota)sq~ZPtC:translocon complexsq~ZPtC:Golgi apparatussq~ZPt C:cytosolsq~ZPt(C:NuA4 histone acetyltransferase complexsq~ZPtC:plasma membranesq~ZiPt C:cytoplasmppppppppppppppppxsq~uq~ sq~PtP:chromosome segregationt7059sq~PtF:protein bindingt5515ppppppppxsq~uq~ sq~Pt IPR000719tProt_kinase_coresq~Pt IPR000687t RIO_kinaseppppppppxsq~uq~ sq~PtRIO1tPF01163pppppppppxtO14730t RIOK3_HUMANsq~uq~ sq~Pt RIO kinase 3sq~Pt sudD homologppppppppxt Homo sapienstIF6sq~P?U*CleA8e%t*Eukaryotic translation initiation factor 6sq~uq~ sq~UA8tENSG00000126005pppppppppxsq~uq~ sq~mA8tEIF6sq~mA8tEIF3Asq~mA8tITGB4BPsq~mA8t OK/SW-cl.27ppppppxsq~uq~ @sq~Z A8t P:translationsq~ZA8tP:signal transductionsq~ZJA8t.P:regulation of progression through cell cyclesq~ZoA8t/P:ubiquitin-dependent protein catabolic processsq~Z9A8tP:protein foldingsq~ZA8tP:cell adhesionsq~ZWA8t P:carbohydrate metabolic processsq~Z [A8tP:cell proliferationsq~ZA8tP:cell motilitysq~ZA8tP:visual perceptionsq~Z.A8t(P:regulation of translational initiationsq~Z@A8tP:protein modification processsq~ZsA8tP:spermatogenesissq~ZFA8t&P:protein amino acid dephosphorylationsq~ZtA8tP:DNA replicationsq~Z=A8tP:glucose transportsq~ZOA8t0P:regulation of cyclin-dependent protein kina...sq~ZA8t/P:transcription from RNA polymerase II promotersq~Z_A8tP:striated muscle developmentsq~ZkA8t&P:multicellular organismal developmentsq~ZA8tP:mitotic cell cycle checkpointsq~ZA8tP:nervous system developmentsq~ZA8t(P:negative regulation of DNA replicationsq~Z UA8t0P:regulation of G-protein coupled receptor pr...sq~Z>A8t P:cell growthsq~ZuA8t*P:protein import into mitochondrial matrixsq~Z'1A8tP:response to organic substancesq~Z$A8t0P:pyrimidine ribonucleotide biosynthetic processsq~Z#A8t.P:ribonucleoside diphosphate catabolic processsq~Z#A8t"P:purine base biosynthetic processsq~Z!A8tP:apoptotic programsq~Z!_A8t0P:fibroblast growth factor receptor signaling...sq~Z A8tP:RNA splicingsq~Z ^A8t$P:insulin receptor signaling pathwaysq~Z ]A8t+P:negative regulation of cell proliferationsq~ZA8tP:cell cycle arrestsq~ZJA8tP:response to unfolded proteinsq~Z*A8tP:inflammatory responsesq~Z%A8tP:tyrosyl-tRNA aminoacylationsq~Z=A8tP:protein complex assemblysq~ZDA8t$P:protein amino acid phosphorylationsq~ZA8tP:ceramide metabolic processsq~ZA8tP:anion transportsq~ZA8t!P:intracellular protein transportsq~ZA8t P:endocytosissq~ZA8t P:apoptosissq~ZA8tP:induction of apoptosissq~ZA8tP:caspase activationsq~ZA8t"P:regulation of muscle contractionsq~Z A8tP:translational initiationsq~ZA8t(P:glycosaminoglycan biosynthetic processsq~ZA8tP:alcohol metabolic processsq~ZA8t0P:generation of precursor metabolites and energysq~ZA8tP:fumarate metabolic processsq~ZA8tP:regulation of DNA replicationsq~ZA8tP:base-excision repairsq~ZA8t,P:regulation of transcription, DNA-dependentsq~ZA8t0P:regulation of transcription from RNA polyme...sq~ZA8tP:RNA processingsq~ZA8tP:RNA catabolic processsq~Z&A8tP:response to stresssq~Z<A8t.P:regulation of survival gene product activitysq~ZzA8t/P:negative regulation of protein ubiquitinationsq~ZA8tP:skeletal developmentsq~ZxA8t0P:cortical actin cytoskeleton organization an...sq~Zw9A8t%P:androgen receptor signaling pathwaysq~ZvA8t'P:negative regulation of cell migrationsq~ZvdA8t$P:negative regulation of cell growthsq~ZA8tP:focal adhesion formationsq~ZxvA8t0P:positive regulation of actin filament polym...sq~Z{)A8t$P:ruffle organization and biogenesissq~Z>A8t)P:negative regulation of collagen bindingsq~ZA8t0P:negative regulation of tyrosine phosphoryla...sq~ZA8t$P:regulation of cell differentiationsq~ZA8tP:regulation of transcriptionsq~ZA8tP:translational elongationsq~ZDA8t0P:negative regulation of transcription, DNA-d...sq~ZA8tP:neuroprotectionsq~ZA8tP:stress fiber formationsq~ZsA8t0P:positive regulation of I-kappaB kinase/NF-k...sq~ZEA8t0P:positive regulation of transcription, DNA-d...sq~ZA8t0P:negative regulation of receptor mediated en...sq~ZuA8tP:regulation of cell adhesionsq~ZMA8t%P:second-messenger-mediated signalingsq~ZA8t/P:regulation of Rac protein signal transductionsq~ZA8t'P:DNA catabolic process, exonucleolyticsq~ZGgA8t0P:protein amino acid N-linked glycosylation v...sq~ZIA8t!P:actin filament bundle formationsq~ZA8tP:inactivation of MAPK activitysq~Z@A8tP:protein deubiquitinationsq~ZA8t0P:mRNA catabolic process, nonsense-mediated d...sq~ZǝA8tP:regulation of DNA bindingsq~ZKgA8tP:D-ribose catabolic processsq~ZA8t P:cytokinesissq~ZuA8t.P:regulation of Wnt receptor signaling pathwaysq~ZWA8t+P:negative regulation of cell-cell adhesionsq~ZƅA8tP:protein stabilizationsq~ZuaA8tP:muscle filament slidingsq~ZA8tP:clathrin cage assemblysq~Z4A8tF:protein bindingsq~ZA8t F:RNA bindingsq~ZA8t0F:translation factor activity, nucleic acid b...sq~ZA8t$F:structural constituent of ribosomesq~Z]A8t F:DNA bindingsq~ZA8t$F:transcription coactivator activitysq~ZNJA8tF:unfolded protein bindingsq~ZTA8tF:GTPase activitysq~Z2A8tF:identical protein bindingsq~ZPA8t(F:structural constituent of cytoskeletonsq~ZA8t F:ATP bindingsq~ZA8t F:GTP bindingsq~ZA8tF:signal transducer activitysq~Z!A8t0F:protein phosphatase type 2A regulator activitysq~Z#_A8tF:electron carrier activitysq~ZuA8tF:ADP reductase activitysq~ZJA8t"F:ADP-sugar diphosphatase activitysq~Z@kA8tF:oxidoreductase activitysq~Z A8tF:3'-5' exonuclease activitysq~ZA8tF:androgen receptor bindingsq~ZA8t0F:ATPase activity, coupled to transmembrane m...sq~ZA8tF:metal ion bindingsq~ZxA8t!F:actin-dependent ATPase activitysq~ZA8t%F:protein heterodimerization activitysq~ZvDA8tF:clathrin bindingsq~ZuA8tF:chaperone activator activitysq~Z sA8t"F:structural constituent of musclesq~ZY<A8t&F:voltage-gated anion channel activitysq~ZǏA8tF:chaperone bindingsq~ZA8tF:ATPase activator activitysq~ZA8tF:phosphodiesterase I activitysq~ZA8t*F:ornithine-oxo-acid transaminase activitysq~ZA8t0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~ZYA8tF:protein kinase C activitysq~ZA8t/F:ribonucleoside-diphosphate reductase activitysq~ZA8tF:transaldolase activitysq~ZA8tF:tyrosine-tRNA ligase activitysq~ZA8t&F:ubiquitin-specific protease activitysq~ZA8t#F:uracil DNA N-glycosylase activitysq~ZA8tF:uridine kinase activitysq~ZA8t"F:phospholipase inhibitor activitysq~ZA8tF:receptor activitysq~ZA8t)F:Rab GDP-dissociation inhibitor activitysq~ZA8tF:receptor bindingsq~Z A8t!F:growth hormone receptor bindingsq~Z!A8t F:interleukin-8 receptor bindingsq~Z&A8tF:insulin receptor bindingsq~ZA8tF:ribonuclease H activitysq~ZA8t F:endodeoxyribonuclease activitysq~ZA8tF:fumarate hydratase activitysq~Z^A8tF:DNA helicase activitysq~ZtA8tF:transcription factor activitysq~ZA8t$F:transcription corepressor activitysq~ZA8t(F:translation initiation factor activitysq~ZA8t(F:translation elongation factor activitysq~ZA8tF:motor activitysq~ZA8tF:actin bindingsq~ZA8tF:antigen bindingsq~ZbA8tF:IMP dehydrogenase activitysq~ZA8tF:acid phosphatase activitysq~ZA8t'F:aldehyde dehydrogenase (NAD) activitysq~ZA8t+F:aldehyde dehydrogenase [NAD(P)+] activitysq~ZA8t%F:carbonyl reductase (NADPH) activitysq~Z A8t F:citrate (Si)-synthase activitysq~ZA8tF:creatine kinase activitysq~ZQA8tF:aminopeptidase activitysq~Z}A8t"F:ubiquitin thiolesterase activitysq~Z;A8tF:hormone activitysq~Z_A8tF:transporter activitysq~ZA8t F:5'-3' exoribonuclease activitysq~ZoA8t(F:nucleocytoplasmic transporter activitysq~ZvA8t0F:RNA polymerase II transcription factor acti...sq~ZBA8t0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~ZA8t C:nucleussq~Zi A8t C:cytoplasmsq~ZkA8tC:mitochondrionsq~ZA8tC:soluble fractionsq~ZA8tC:membrane fractionsq~ZA8tC:mitochondrial matrixsq~ZA8t0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZA8t&C:proteasome complex (sensu Eukaryota)sq~ZbA8t C:nucleolussq~ZA8tC:plasma membranesq~ZWA8t!C:perinuclear region of cytoplasmsq~ZA8t0C:eukaryotic translation initiation factor 3 ...sq~ZA8t C:cytosolsq~ZA8t%C:protein phosphatase type 2A complexsq~ZA8tC:cytoskeletonsq~ZA8tC:intracellularsq~ZA8t"C:muscle thin filament tropomyosinsq~ZA8tC:integral to plasma membranesq~ZAA8t C:lipid raftsq~Z$A8t"C:cell-substrate adherens junctionsq~ZRA8tC:pore complexsq~ZA8t C:kinetochoresq~ZA8tC:synaptonemal complexsq~ZA8tC:stress fibersq~ZA8tC:zonula adherenssq~Z@MA8tC:unconventional myosin complexsq~ZA8tC:rufflesq~ZSA8t.C:ribonucleoside-diphosphate reductase complexsq~Z2A8t C:cell cortexsq~ZA8tC:cytosolic partsq~ZA8t0C:eukaryotic translation elongation factor 1 ...sq~ZmA8tC:mitochondrial outer membranesq~ZA8t C:nucleoplasmsq~Z'A8tC:cell surfacesq~ZA8tC:extracellular spacesq~Z= A8tC:actin cytoskeletonsq~Z=A8tC:microtubule cytoskeletonsq~Z@A8t C:PML bodysq~Z>A8tC:integral to membranesq~Z>A8t C:membranesq~ZyA8t0C:mitochondrial proton-transporting ATP synth...sq~Z qA8tC:integrin complexsq~ZA8t0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZA8t C:ribosomesq~ZA8t(C:NuA4 histone acetyltransferase complexsq~Z :A8t$C:oligosaccharyl transferase complexsq~ZA8tC:Golgi apparatussq~ZA8tC:endoplasmic reticulumsq~ZA8t C:endosomesq~ZxA8t C:VCB complexsq~Z?A8tC:prefoldin complexpppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~A8tF:protein bindingt5515sq~A8t C:nucleust5634ppppppppxsq~uq~ sq~A8t IPR002769teIF6pppppppppxsq~uq~ sq~A8teIF-6tPF01912pppppppppxtP56537t IF6_HUMANsq~uq~ sq~A8teIF-6sq~A8tB4 integrin interactorsq~A8tCABsq~A8tp27(BBP)sq~A8tB(2)GCN homologpppppxt Homo sapienstRIPK2sq~P?TLQLR%t6Receptor-interacting serine/threonine-protein kinase 2sq~uq~ sq~ULtENSG00000104312pppppppppxsq~uq~ sq~mLtRIPK2sq~mLtCARDIAKsq~mLtRICKsq~mLtRIP2sq~mLtUNQ277/PRO314/PRO340pppppxsq~uq~ @sq~Zs Lt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZJLtP:response to unfolded proteinsq~Z=LtP:protein complex assemblysq~ZDLt$P:protein amino acid phosphorylationsq~ZLtP:cell motilitysq~ZRLt)P:activation of NF-kappaB-inducing kinasesq~Z Lt P:translationsq~Z&LtP:response to stresssq~ZLt(P:protein amino acid autophosphorylationsq~ZLt0P:cell surface receptor linked signal transdu...sq~ZLtP:signal transductionsq~ZƤLt#P:T cell receptor signaling pathwaysq~ZLt P:glycolysissq~ZKLtP:protein kinase cascadesq~Z@LtP:protein modification processsq~Z;LtP:protein oligomerizationsq~ZpLtP:ubiquitin cyclesq~ZLtP:defense response to bacteriumsq~ZuLt&P:positive regulation of transcriptionsq~ZoLt/P:ubiquitin-dependent protein catabolic processsq~ZlLt P:proteolysissq~Z*LtP:inflammatory responsesq~ZLtP:fatty acid beta-oxidationsq~ZLt P:apoptosissq~Z9LtP:protein foldingsq~ZLtP:anti-apoptosissq~ZƶLt*P:positive regulation of T cell activationsq~Z=Lt%P:integrin-mediated signaling pathwaysq~Z!LtP:apoptotic programsq~ZLtP:induction of apoptosissq~Z>LtP:detection of bacteriumsq~Z Lt0P:positive regulation of T cell cytokine prod...sq~ZǔLt.P:activation of NF-kappaB transcription factorsq~ZOLt P:protein amino acid methylationsq~ZuLtP:cell differentiationsq~Zu`LtP:actin filament-based movementsq~ZuLtP:platelet activationsq~Z:LtP:protein transportsq~ZKLt0P:cytokine and chemokine mediated signaling p...sq~ZuLtP:protein repairsq~Z@aLt&P:negative regulation of transcriptionsq~ZLt0P:tricarboxylic acid cycle intermediate metab...sq~Z>LtP:detection of fungussq~ZLtP:rRNA processingsq~ZLt,P:regulation of transcription, DNA-dependentsq~Z&LtP:organ morphogenesissq~Z%LtP:response to external stimulussq~Zv LtP:platelet formationsq~ZmLt)P:membrane protein ectodomain proteolysissq~ZLtP:leukocyte adhesionsq~ZLtP:signal complex assemblysq~Z Lt0P:transmembrane receptor protein serine/threo...sq~ZLtP:SMAD protein complex assemblysq~ZQLt#P:I-kappaB kinase/NF-kappaB cascadesq~ZVLt P:JNK cascadesq~ZvLtP:spermatid developmentsq~ZLtP:ectoderm developmentsq~Z!Lt0P:induction of apoptosis by extracellular sig...sq~Z [LtP:cell proliferationsq~ZLtP:male meiosissq~ZLt P:mitosissq~ZhLtP:cytoskeletal anchoringsq~ZLtP:lipid metabolic processsq~Z%Lt!P:prostaglandin metabolic processsq~ZLtP:anion transportsq~ZLtP:mitochondrial transportsq~Z LtP:regulation of cell shapesq~ZLt P:chemotaxissq~ZLtP:striated muscle contractionsq~Z+LtP:immune responsesq~ZiLtP:microtubule-based processsq~Z!`LtP:epidermis developmentsq~ZJLt.P:regulation of progression through cell cyclesq~ZLt0P:positive regulation of interleukin-1 beta s...sq~ZLt0P:negative regulation of hemoglobin biosynthe...sq~ZLt0P:negative regulation of translational initia...sq~ZxLt0P:positive regulation of transcription from R...sq~ZELt0P:positive regulation of transcription, DNA-d...sq~ZLt0P:G-protein coupled receptor protein signalin...sq~ZDLt0P:negative regulation of transcription, DNA-d...sq~ZgLt0P:negative regulation of osteoclast different...sq~ZuLt0P:positive regulation of nitric oxide biosynt...sq~ZhLt0P:positive regulation of interleukin-8 biosyn...sq~ZLt0P:positive regulation of interleukin-12 biosy...sq~ZLt0P:ribosomal small subunit assembly and mainte...sq~Z ZLt0P:negative regulation of mature B cell apoptosissq~ZLtP:adaptive immune responsesq~ZzLt0P:negative regulation of transcription from R...sq~Z<LtP:protein homooligomerizationsq~ZLtP:protein polyubiquitinationsq~ZILt!P:actin filament bundle formationsq~ZLt P:cytokinesissq~ZLtP:angiogenesissq~ZLtP:leukocyte migrationsq~Z3LtP:neural tube closuresq~Z)Lt.P:positive regulation of inflammatory responsesq~ZLt&P:toll-like receptor signaling pathwaysq~ZLt*P:response to molecule of bacterial originsq~ZLt)P:blood vessel endothelial cell migrationsq~Z*LtP:protein refoldingsq~ZLt$P:interleukin-6 biosynthetic processsq~ZLtP:response to chemical stimulussq~ZLtP:macrophage activationsq~Z}Lt$P:lymphotoxin A biosynthetic processsq~Z{,Lt#P:actin cytoskeleton reorganizationsq~Z~Lt P:detection of muramyl dipeptidesq~ZLt0P:positive regulation of mast cell cytokine p...sq~ZtLtP:B cell proliferationsq~ZhLt!P:T-helper 1 type immune responsesq~ZLt$P:interleukin-8 biosynthetic processsq~ZLt+P:natural killer cell mediated cytotoxicitysq~ZvLtP:monocyte differentiationsq~ZvLtP:myofibril assemblysq~ZvdLt$P:negative regulation of cell growthsq~ZwLtP:maturation of SSU-rRNAsq~Zw2Lt.P:negative regulation of BMP signaling pathwaysq~ZwLtP:neutrophil chemotaxissq~Z#Lt0P:protein ubiquitination during ubiquitin-dep...sq~ZzLt/P:positive regulation of protein ubiquitinationsq~ZWLt(P:positive regulation of phosphorylationsq~Z%LtF:protein bindingsq~Z LtF:signal transducer activitysq~ZLt F:ATP bindingsq~ZLt#F:ubiquitin-protein ligase activitysq~ZLt F:RNA bindingsq~ZiLt"F:protein-tyrosine kinase activitysq~ZBLt*F:protein serine/threonine kinase activitysq~Z3Lt#F:protein homodimerization activitysq~ZtLtF:transcription factor activitysq~ZLt$F:structural constituent of ribosomesq~Z2LtF:identical protein bindingsq~ZRLtF:peptidoglycan bindingsq~ZGLtF:actin filament bindingsq~ZeLtF:protein self-associationsq~Z@Lt"F:transcription activator activitysq~ZwLtF:caspase activitysq~Z!LtF:caspase activator activitysq~ZPLt(F:structural constituent of cytoskeletonsq~ZLt!F:transmembrane receptor activitysq~Z Lt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZLtF:enoyl-CoA hydratase activitysq~Z`Lt$F:NF-kappaB-inducing kinase activitysq~ZaLtF:JUN kinase activitysq~ZLtF:alpha-actinin bindingsq~Z|Lt*F:N-terminal myristoylation domain bindingsq~Z~LtF:muramyl dipeptide bindingsq~Z{Lt"F:ubiquitin protein ligase bindingsq~ZdLtF:MAP kinase kinase activitysq~ZxLtF:TPR domain bindingsq~Z@LtF:protein kinase activitysq~ZLt$F:phosphopyruvate hydratase activitysq~ZkLt"F:L-lactate dehydrogenase activitysq~ZOLtF:endopeptidase activitysq~ZLt'F:acetyl-CoA C-acyltransferase activitysq~ZLt*F:3-hydroxyacyl-CoA dehydrogenase activitysq~ZLtF:protein anchorsq~ZLt F:GTP bindingsq~ZkLt0F:non-membrane spanning protein tyrosine kina...sq~ZoLt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~ZLtF:receptor activitysq~ZzLtF:ubiquitin bindingsq~ZLt)F:tumor necrosis factor receptor activitysq~ZLtF:ATPase activity, coupledsq~ZLtF:SH3/SH2 adaptor activitysq~Z0LtF:MHC class I protein bindingsq~Z:LtF:integrin bindingsq~Z_LtF:transporter activitysq~ZLtF:fatty acid bindingsq~ZLtF:SH2 domain bindingsq~ZLtF:calcium ion bindingsq~ZLtF:calmodulin bindingsq~ZLtF:protein kinase B bindingsq~Zv{LtF:estrogen receptor bindingsq~ZLtF:actin bindingsq~ZMKLt+F:small conjugating protein ligase activitysq~Z LtF:MP kinase activitysq~ZALtF:ATPase activitysq~ZsLtF:NF-kappaB bindingsq~Z@Lt-F:specific transcriptional repressor activitysq~ZLt!F:transcription cofactor activitysq~ZDŽLt!F:Gram-positive bacterial bindingsq~ZNJLtF:unfolded protein bindingsq~ZB~LtF:myosin bindingsq~ZLtF:magnesium ion bindingsq~ZLtF:microfilament motor activitysq~Z"1Lt(F:NADPH dehydrogenase (quinone) activitysq~ZWLt F:NAD bindingsq~ZVLtF:protein C-terminus bindingsq~Z sLt"F:structural constituent of musclesq~ZLtF:lipopolysaccharide bindingsq~ZMLtF:enzyme bindingsq~ZVLt0F:eukaryotic translation initiation factor 2a...sq~Z LtF:CARD domain bindingsq~ZLt$F:transcription coactivator activitysq~ZvLt*F:nitric-oxide synthase regulator activitysq~ZY<Lt&F:voltage-gated anion channel activitysq~ZLt$F:transcription corepressor activitysq~ZNELtF:heme bindingsq~ZMLtF:protein kinase bindingsq~ZSLt&F:lipopolysaccharide receptor activitysq~Zi Lt C:cytoplasmsq~ZLt C:nucleussq~ZLtC:integral to plasma membranesq~ZLt C:cytosolsq~ZLtC:cytoskeletonsq~Z'LtC:cell surfacesq~ZLtC:plasma membranesq~ZLtC:intracellularsq~ZLt&C:proteasome complex (sensu Eukaryota)sq~ZLtC:stress fibersq~ZLt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z}LtC:cleavage furrowsq~ZLtC:rufflesq~ZkLtC:mitochondrionsq~ZbLt C:nucleolussq~ZLtC:extracellular regionsq~ZMLtC:extrinsic to membranesq~ZuBLtC:Z discsq~ZLt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZLt C:microtubulesq~ZLt+C:proteasome core complex (sensu Eukaryota)sq~ZLtC:contractile ringsq~ZWLt!C:perinuclear region of cytoplasmsq~ZLtC:synaptonemal complexsq~ZLtC:condensed nuclear chromosomesq~Z@Lt C:PML bodysq~ZLtC:intermediate filamentsq~Z@KLtC:myosin complexsq~ZLtC:actin filamentsq~ZLt C:microvillussq~Z2Lt C:cell cortexsq~ZBLt0C:calcium- and calmodulin-dependent protein k...sq~ZLtC:endoplasmic reticulumsq~ZRLtC:pore complexsq~ZLtC:protein complexsq~ZuLtC:T cell receptor complexsq~Z#LtC:transcription factor complexsq~Z~Lt C:CBM complexsq~Z|Lt C:vesiclesq~Z Lt C:interleukin-1 receptor complexsq~ZxLtC:cortical cytoskeletonsq~ZlLtC:mitochondrial envelopesq~ZwDLt)C:small nuclear ribonucleoprotein complexsq~ZwALtC:ribonucleoprotein complexsq~ZmLtC:mitochondrial outer membranesq~Zw Lt C:midbodysq~ZoLtC:mitochondrial inner membranesq~ZyLt0C:mitochondrial proton-transporting ATP synth...sq~ZhLt%C:lipopolysaccharide receptor complexsq~ZLt C:lysosomesq~ZLtC:cytoplasmic partpppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Lt P:apoptosist6915sq~LtP:inflammatory responset6954sq~Lt0P:positive regulation of I-kappaB kinase/NF-k...t43123sq~LtF:CARD domain bindingt50700sq~LtF:LIM domain bindingt30274sq~Lt*F:protein serine/threonine kinase activityt4674sq~LtF:signal transducer activityt4871pppxsq~uq~ sq~Lt IPR001315tCARDsq~Lt IPR011029t DEATH_likesq~Lt IPR000719tProt_kinase_coresq~Lt IPR008271tSer_thr_pkin_ASppppppxsq~uq~ sq~LtCARDtPF00619sq~LtPkinasetPF00069ppppppppxtO43353t RIPK2_HUMANsq~uq~ sq~Lt!RIP-like-interacting CLARP kinasesq~LtReceptor-interacting protein 2sq~LtRIP-2sq~LtFCARD-containing interleukin-1 beta-converting enzyme-associated kinasesq~Lt$CARD-containing IL-1 beta ICE-kinasepppppxt Homo sapienstHSPB1sq~P?[-E%-%tHeat shock protein beta-1sq~uq~ sq~UE%tENSG00000106211pppppppppxsq~uq~ sq~mE%tHSPB1sq~mE%tHSP27ppppppppxsq~uq~ sq~ZE%tP:signal transductionsq~ZE%t,P:regulation of transcription, DNA-dependentsq~ZE%tP:anti-apoptosissq~Z [E%tP:cell proliferationsq~Z~E%t0P:negative regulation of intracellular transportsq~ZDE%t$P:protein amino acid phosphorylationsq~Z!E%t%P:caspase activation via cytochrome csq~Z9E%tP:protein foldingsq~Zw9E%t%P:androgen receptor signaling pathwaysq~ZE%t0P:regulation of transcription from RNA polyme...sq~ZE%tP:cell motilitysq~ZE%tP:muscle contractionsq~ZE%t$P:DNA fragmentation during apoptosissq~ZE%tP:visual perceptionsq~Z \E%t+P:positive regulation of cell proliferationsq~ZE%t P:cell agingsq~ZE%tP:nervous system developmentsq~ZE%tP:transcription initiationsq~ZE%tP:ectoderm developmentsq~ZaE%t!P:Ras protein signal transductionsq~ZkE%t&P:multicellular organismal developmentsq~ZYE%tP:activation of JNK activitysq~ZE%tP:nucleotide-excision repairsq~ZcE%tP:cell-cell signalingsq~ZE%t/P:transcription from RNA polymerase II promotersq~ZE%tP:RNA export from nucleussq~ZJE%t!P:intracellular signaling cascadesq~Z=E%t%P:integrin-mediated signaling pathwaysq~ZE%t0P:transmembrane receptor protein tyrosine kin...sq~ZE%tP:cell-matrix adhesionsq~ZE%tP:cell adhesionsq~ZE%tP:cell cycle arrestsq~Z[E%tP:JAK-STAT cascadesq~Z&E%tP:response to stresssq~ZE%t P:apoptosissq~ZnE%tP:ATP-dependent proteolysissq~Z@E%tP:protein modification processsq~ZE%tP:phosphate metabolic processsq~Z.E%t(P:regulation of translational initiationsq~Z E%t P:translationsq~ZUE%t'P:cytoplasmic sequestering of NF-kappaBsq~ZE%tP:blood coagulationsq~ZPE%t!P:regulation of heart contractionsq~ZGE%tP:ER overload responsesq~ZE%tP:regulation of apoptosissq~ZE%t+P:cell envelope organization and biogenesissq~ZE%t$P:negative regulation of DNA bindingsq~ZE%tP:cellular respirationsq~ZDE%t0P:negative regulation of transcription, DNA-d...sq~ZEE%t0P:positive regulation of transcription, DNA-d...sq~ZE%t0P:DNA damage response, signal transduction by...sq~Z6E%t0P:regulation of mitochondrial membrane permea...sq~ZE%t0P:negative regulation of epithelial cell prol...sq~ZE%t(P:nuclear mRNA splicing, via spliceosomesq~ZE%tP:MAPKKK cascadesq~ZǙE%t*P:negative regulation of helicase activitysq~ZzE%t0P:negative regulation of transcription from R...sq~ZE%t)P:cellular response to glucose starvationsq~ZE%tP:nuclear importsq~ZE%tP:protein localizationsq~Z ]E%t+P:negative regulation of cell proliferationsq~Z!_E%t0P:fibroblast growth factor receptor signaling...sq~Z!E%t0P:induction of apoptosis via death domain rec...sq~ZE%tP:base-excision repairsq~Z>E%tP:protein tetramerizationsq~ZKE%t0P:cytokine and chemokine mediated signaling p...sq~ZuE%tP:cell differentiationsq~ZvE%tP:keratinocyte differentiationsq~ZvdE%t$P:negative regulation of cell growthsq~ZE%tF:protein bindingsq~ZBE%t*F:protein serine/threonine kinase activitysq~ZtE%tF:transcription factor activitysq~ZE%tF:transcription factor bindingsq~Z NE%tF:zinc ion bindingsq~ZE%tF:androgen receptor bindingsq~Z}E%tF:protein N-terminus bindingsq~ZME%tF:enzyme bindingsq~ZcE%t0F:electron transporter, transferring electron...sq~Z2E%tF:identical protein bindingsq~ZE%t F:ATP bindingsq~ZdE%tF:MAP kinase kinase activitysq~ZE%t0F:protein-glutamine gamma-glutamyltransferase...sq~ZE%t(F:translation initiation factor activitysq~ZE%t$F:transcription coactivator activitysq~Zy`E%tF:heat shock protein bindingsq~Zw@E%t"F:transcription regulator activitysq~ZsE%tF:NF-kappaB bindingsq~ZKE%t"F:inorganic diphosphatase activitysq~Zw,E%t0F:thiol-disulfide exchange intermediate activitysq~ZE%tF:signal transducer activitysq~ZE%t%F:receptor signaling protein activitysq~ZE%t0F:hematopoietin/interferon-class (D200-domain...sq~Z@E%tF:protein kinase activitysq~ZE%tF:ribonuclease P activitysq~ZE%t$F:transcription corepressor activitysq~ZE%t F:RNA bindingsq~ZE%tF:single-stranded RNA bindingsq~ZE%t$F:structural constituent of ribosomesq~ZAE%tF:ATPase activitysq~ZqE%tF:single-stranded DNA bindingsq~ZE%tF:DNA strand annealing activitysq~ZE%tF:nuclease activitysq~ZNEE%tF:heme bindingsq~ZNE%tF:structural molecule activitysq~ZPE%t(F:structural constituent of cytoskeletonsq~ZE%t'F:nuclear localization sequence bindingsq~ZE%t%F:protein heterodimerization activitysq~Z sE%t"F:structural constituent of musclesq~ZE%tF:copper ion bindingsq~Z{E%t"F:ubiquitin protein ligase bindingsq~Z\E%t$F:structural constituent of eye lenssq~Zi E%t C:cytoplasmsq~ZE%t C:nucleussq~ZE%tC:intracellularsq~ZE%t&C:proteasome complex (sensu Eukaryota)sq~ZE%t C:cytosolsq~ZE%t C:nucleoplasmsq~Z~E%t#C:mitochondrial intermembrane spacesq~ZkE%tC:mitochondrionsq~ZE%t%C:protein phosphatase type 2A complexsq~ZE%tC:cornified envelopesq~ZE%tC:intermediate filamentsq~ZE%tC:actin filamentsq~ZE%t0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZbE%t C:nucleolussq~Z?E%t0C:eukaryotic translation initiation factor 4F...sq~ZE%tC:extracellular regionsq~ZwBE%t0C:heterogeneous nuclear ribonucleoprotein com...sq~ZyE%tC:intrinsic to membranesq~Z?E%tC:nuclear matrixsq~ZE%tC:insoluble fractionsq~ZvE%tC:histone deacetylase complexsq~ZE%t"C:nucleolar ribonuclease P complexsq~Z#E%tC:transcription factor complexsq~Z1E%t C:spliceosomesq~ZE%tC:protein complexppppppppppppppppppppppppxsq~uq~ sq~E%tP:anti-apoptosist6916sq~E%tP:cell motilityt6928sq~E%t(P:regulation of translational initiationt6446sq~E%tP:response to unfolded proteint6986sq~E%tF:protein bindingt5515sq~E%tC:cell surfacet9986sq~E%t C:cytoplasmt5737sq~E%tC:cytoskeletont5856ppxsq~uq~ sq~E%t IPR001436tAlpha-crystallin/HSPsq~E%t IPR002068tHsp20ppppppppxsq~uq~ sq~E%tHSP20tPF00011pppppppppxtP04792t HSPB1_HUMANsq~uq~ sq~E%tHspB1sq~E%tHeat shock 27 kDa proteinsq~E%tHSP 27sq~E%tStress-responsive protein 27sq~E%tSRP27sq~E%t!Estrogen-regulated 24 kDa proteinsq~E%t28 kDa heat shock proteinpppxt Homo sapienstRIPK5sq~P?Q)%t6Receptor-interacting serine/threonine-protein kinase 5sq~uq~ sq~UQ)tENSG00000133059pppppppppxsq~uq~ sq~mQ)tRIPK5sq~mQ)tKIAA0472sq~mQ)tRIP5sq~mQ)tSGK496sq~mQ)tHDCMD38Ppppppxsq~7uq~ Psq~Z`Q)t+P:small GTPase mediated signal transductionsq~Z Q)t P:translationsq~ZQ)t0P:cell surface receptor linked signal transdu...sq~ZQ)tP:mitotic cell cycle checkpointsq~ZJQ)tP:response to unfolded proteinsq~Z+Q)tP:immune responsesq~ZQ)tP:caspase activationsq~ZoQ)t/P:ubiquitin-dependent protein catabolic processsq~ZDQ)t$P:protein amino acid phosphorylationsq~ZQ)tP:Golgi to endosome transportsq~Z9Q)tP:protein foldingsq~ZeQ)tP:neurotransmitter secretionsq~ZQ)tP:regulation of translationsq~Z:Q)t"P:negative regulation of apoptosissq~ZQ)t%P:regulation of macrophage activationsq~ZsQ)t0P:positive regulation of I-kappaB kinase/NF-k...sq~ZuQ)tP:neuron differentiationsq~Z?JQ)t+P:regulation of striated muscle developmentsq~Z>Q)t P:cell growthsq~Z:Q)tP:protein transportsq~Z [Q)tP:cell proliferationsq~ZQ)t$P:prostaglandin biosynthetic processsq~Z Q)tF:protein bindingsq~ZTQ)tF:GTPase activitysq~ZNJQ)tF:unfolded protein bindingsq~ZǏQ)tF:chaperone bindingsq~Z_Q)tF:transporter activitysq~ZQ)t F:GTP bindingsq~ZQ)tF:cytokine activitysq~ZQ)t#F:ubiquitin-protein ligase activitysq~Z`Q)t$F:NF-kappaB-inducing kinase activitysq~ZGQ)tF:dopachrome isomerase activitysq~ZQ)t$F:structural constituent of ribosomesq~ZQ)t F:RNA bindingsq~ZQ)t F:ATP bindingsq~ZQ)t&C:proteasome complex (sensu Eukaryota)sq~ZQ)tC:plasma membranesq~ZuQ)t'C:trans-Golgi network transport vesiclesq~ZQ)t C:kinetochoresq~Z>Q)t C:membranesq~ZWQ)t!C:perinuclear region of cytoplasmsq~ZQ)t0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZQ)t C:cytosolsq~ZQ)t C:Golgi stacksq~ZQ)tC:rough endoplasmic reticulumsq~ZQ)tC:late endosomesq~ZQ)t C:lysosomesq~ZQ)tC:mitochondrial matrixsq~ZQ)tC:early endosomesq~ZkQ)tC:mitochondrionsq~ZiQ)t C:cytoplasmsq~ZQ)tC:membrane fractionsq~ZQ)tC:intracellularsq~ZQ)tC:extracellular regionsq~ZQ)t0C:nuclear envelope-endoplasmic reticulum networkpppppppppppppppppppppppppxsq~uq~ sq~Q)tF:protein bindingt5515pppppppppxsq~uq~ sq~Q)t IPR000719tProt_kinase_coresq~Q)t IPR008271tSer_thr_pkin_ASppppppppxsq~uq~ sq~Q)tPkinasetPF00069pppppppppxtQ6XUX3t RIPK5_HUMANsq~uq~ sq~Q)tDusty protein kinasesq~Q)tDusty PKsq~Q)tRIP-homologous kinasesq~Q)tSugen kinase 496ppppppxt Homo sapienstQ6IBU1sq~P?J@F*cPd%t TSC22 proteinsq~uq~ sq~UPtENSG00000102804pppppppppxsq~uq~ sq~mPtTSC22sq~mPtTSC22D1sq~mPtRP11-269C23.2-002sq~mPt hCG_32172ppppppxsq~uq~ @sq~Z Pt P:translationsq~ZJPtP:response to unfolded proteinsq~Z9PtP:protein foldingsq~Z=PtP:protein complex assemblysq~ZPt(P:ER to Golgi vesicle-mediated transportsq~Z@aPt&P:negative regulation of transcriptionsq~Z [PtP:cell proliferationsq~Z \Pt+P:positive regulation of cell proliferationsq~ZPt!P:intracellular protein transportsq~ZPt P:DNA repairsq~ZPt0P:mitochondrial electron transport, NADH to u...sq~ZtPtP:DNA replicationsq~ZPtP:cell cycle arrestsq~ZPtP:nucleotide-excision repairsq~ZPtP:nervous system developmentsq~ZPtP:gluconeogenesissq~ZPt(P:intra-Golgi vesicle-mediated transportsq~ZPt0P:traversing start control point of mitotic c...sq~ZPt-P:mitotic spindle organization and biogenesissq~ZPt P:endocytosissq~ZPtP:anti-apoptosissq~ZPtP:cell motilitysq~ZjPtP:microtubule-based movementsq~Z+PtP:immune responsesq~Z^Pt0P:mitochondrial membrane organization and bio...sq~ZPt0P:retrograde vesicle-mediated transport, Golg...sq~ZFPt&P:protein amino acid dephosphorylationsq~ZPtP:regulation of DNA replicationsq~ZPt,P:regulation of transcription, DNA-dependentsq~ZPt0P:regulation of transcription from RNA polyme...sq~ZPtP:rRNA processingsq~ZPt0P:RNA elongation from RNA polymerase II promotersq~Z.Pt(P:regulation of translational initiationsq~ZjPt!P:GPI anchor biosynthetic processsq~ZlPt P:proteolysissq~ZPtP:protein export from nucleussq~ZPtP:ceramide metabolic processsq~ZPtP:sodium ion transportsq~ZPtP:calcium ion transportsq~ZPtP:dicarboxylic acid transportsq~Z~PtP:DNA replication initiationsq~ZPtP:mitotic cell cycle checkpointsq~Z?JPt+P:regulation of striated muscle developmentsq~Z@PtP:histone phosphorylationsq~ZFPt!P:peptidyl-serine phosphorylationsq~ZFPt$P:peptidyl-threonine phosphorylationsq~ZGgPt0P:protein amino acid N-linked glycosylation v...sq~ZGPt0P:protein amino acid C-linked glycosylation v...sq~ZuTPt0P:actin cytoskeleton organization and biogenesissq~ZwPtP:maturation of SSU-rRNAsq~ZPt+P:protein amino acid O-linked mannosylationsq~ZPtP:response to drugsq~ZPt)P:negative regulation of caspase activitysq~Z5Pt$P:intermediate filament organizationsq~ZDPt0P:negative regulation of transcription, DNA-d...sq~ZEPt0P:positive regulation of transcription, DNA-d...sq~ZPt(P:protein amino acid autophosphorylationsq~ZPt%P:phosphoinositide-mediated signalingsq~Z>PtP:mRNA metabolic processsq~Z>Pt P:cell growthsq~Z=PtP:tryptophan transportsq~ZPt0P:mitotic cell cycle spindle assembly checkpointsq~ZPt!P:regulation of exit from mitosissq~ZPt P:meiosissq~ZPt0P:G-protein signaling, adenylate cyclase inhi...sq~ZQPt#P:I-kappaB kinase/NF-kappaB cascadesq~ZVPt P:JNK cascadesq~ZYPtP:activation of JNK activitysq~Z`Pt+P:small GTPase mediated signal transductionsq~ZcPtP:cell-cell signalingsq~Z ]Pt+P:negative regulation of cell proliferationsq~Z!Pt0P:induction of apoptosis by intracellular sig...sq~Z$Pt0P:folic acid and derivative biosynthetic processsq~Z%PtP:response to hormone stimulussq~Z&PtP:organ morphogenesissq~Z=pPtP:mevalonate transportsq~Z=PtP:glutamate transportsq~ZnPtP:metaphase plate congressionsq~ZPt0P:ribosomal small subunit assembly and mainte...sq~ZPt(P:nuclear mRNA splicing, via spliceosomesq~ZȶPtP:kinetochore assemblysq~ZPt0P:two-component signal transduction system (p...sq~ZVPt'P:G2/M transition of mitotic cell cyclesq~ZUPt P:G2 phase of mitotic cell cyclesq~ZRPt'P:G1/S transition of mitotic cell cyclesq~ZPPt P:G1 phase of mitotic cell cyclesq~ZLPtP:DNA replication checkpointsq~ZFPt&P:mitotic sister chromatid segregationsq~ZPt0P:establishment and/or maintenance of cell po...sq~ZJPt.P:regulation of progression through cell cyclesq~Z8PtF:protein bindingsq~ZPt F:RNA bindingsq~ZPt$F:structural constituent of ribosomesq~Z3Pt#F:protein homodimerization activitysq~ZPt*F:NADH dehydrogenase (ubiquinone) activitysq~ZPtF:ATPase activity, coupledsq~Zv{PtF:estrogen receptor bindingsq~ZPtF:GTPase activator activitysq~ZPtF:actin bindingsq~ZtPtF:transcription factor activitysq~ZPt$F:transcription coactivator activitysq~Z;Pt/F:mevalonate transmembrane transporter activitysq~ZqPtF:single-stranded DNA bindingsq~ZPPt"F:ATP-dependent peptidase activitysq~ZPt0F:translation factor activity, nucleic acid b...sq~ZPtF:microtubule motor activitysq~ZPtF:catalytic activitysq~ZTPtF:GTPase activitysq~ZVPtF:protein C-terminus bindingsq~ZPtF:transcription factor bindingsq~ZIPt0F:dolichyl-phosphate-mannose-protein mannosyl...sq~ZdPtF:damaged DNA bindingsq~Z]Pt F:DNA bindingsq~Z}PtF:protein N-terminus bindingsq~ZPt%F:protein heterodimerization activitysq~ZPtF:dynein bindingsq~Z PtF:ribonucleoprotein bindingsq~Z2PtF:identical protein bindingsq~Z~PtF:MutLalpha complex bindingsq~Zy`PtF:heat shock protein bindingsq~ZwPtF:protein binding, bridgingsq~ZPtF:nucleotide bindingsq~ZuPt.F:receptor signaling complex scaffold activitysq~ZMPtF:protein kinase bindingsq~ZMPtF:enzyme bindingsq~ZK%PtF:centromeric DNA bindingsq~ZPtF:ATPase activator activitysq~Z@Pt-F:specific transcriptional repressor activitysq~Z\PtF:nucleic acid bindingsq~ZǏPtF:chaperone bindingsq~ZPt*F:formate-tetrahydrofolate ligase activitysq~ZNPtF:structural molecule activitysq~ZPt0F:dicarboxylic acid transmembrane transporter...sq~ZPt0F:L-glutamate transmembrane transporter activitysq~Z8Pt$F:calcium:sodium antiporter activitysq~ZPtF:calcium ion bindingsq~ZPtF:calmodulin bindingsq~ZMPtF:interleukin-1 bindingsq~ZPtF:collagen bindingsq~ZPt F:ATP bindingsq~ZPt)F:nuclear export signal receptor activitysq~ZPt.F:serine-type endopeptidase inhibitor activitysq~Z}Pt0F:methenyltetrahydrofolate cyclohydrolase act...sq~ZPt0F:methylenetetrahydrofolate dehydrogenase (NA...sq~ZPt0F:dolichyl-phosphate beta-D-mannosyltransfera...sq~ZBPt*F:protein serine/threonine kinase activitysq~ZUPt*F:cyclin-dependent protein kinase activitysq~ZbPtF:chromatin bindingsq~ZuPt'F:protein tyrosine phosphatase activitysq~ZrPt/F:protein serine/threonine phosphatase activitysq~ZPt C:nucleussq~ZkPtC:mitochondrionsq~ZiPt C:cytoplasmsq~ZPtC:endoplasmic reticulumsq~Z>PtC:integral to membranesq~ZuPtC:COPI vesicle coatsq~ZPtC:plasma membranesq~ZPtC:cytoskeletonsq~ZPtC:nuclear envelopesq~ZPt"C:DNA replication factor C complexsq~ZsPt+C:mitochondrial respiratory chain complex Isq~ZPt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZoPtC:mitochondrial inner membranesq~ZPtC:membrane fractionsq~Z= PtC:actin cytoskeletonsq~ZPtC:spindle polesq~Z'PtC:cell surfacesq~ZPt&C:proteasome complex (sensu Eukaryota)sq~ZPtC:translocon complexsq~ZPtC:protein complexsq~ZPt C:endoplasmic reticulum membranesq~ZPt#C:ER-Golgi intermediate compartmentsq~ZPtC:kinetochore microtubulesq~ZPt C:cytosolsq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z0PtC:endomembrane systemsq~ZPtC:integral to plasma membranesq~ZWPt!C:perinuclear region of cytoplasmsq~ZPtC:cytoplasmic dynein complexsq~Z :Pt$C:oligosaccharyl transferase complexsq~ZpPt0C:mitochondrial inner membrane presequence tr...sq~ZPtC:mitochondrial matrixsq~Z>Pt C:membranesq~ZPtC:soluble fractionsq~ZPt C:kinetochoresq~Z PtC:nuclear poresq~ZPt+C:outer kinetochore of condensed chromosomesq~ZPt&C:alpha DNA polymerase:primase complexsq~Z@PtC:nuclear specksq~Z+PtC:holo TFIIH complexsq~Z1Pt C:spliceosomesq~ZbPt C:nucleolussq~ZPtC:intracellularsq~Z{ PtC:mannosyltransferase complexsq~ZPtC:basement membranesq~Z?PtC:nuclear matrixsq~ZPt C:ribosomesq~ZwDPt)C:small nuclear ribonucleoprotein complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Pt,P:regulation of transcription, DNA-dependentt6355sq~PtF:transcription factor activityt3700ppppppppxsq~uq~ sq~Pt IPR000580tTSC-22_Dip_Bunpppppppppxsq~uq~ sq~PtTSC22tPF01166pppppppppxtQ6IBU1t Q6IBU1_HUMANsq~uq~ sq~Pt,TSC22 domain family, member 1, isoform CRA_asq~PtTSC22 domain family, member 1ppppppppxt Homo sapienstXRN2sq~P?w@%t5'-3' exoribonuclease 2sq~uq~ sq~U@tENSG00000088930pppppppppxsq~uq~ sq~m@tXRN2pppppppppxsq~&uq~ (sq~Z@t0P:mRNA catabolic process, nonsense-mediated d...sq~Z@tP:mRNA processingsq~Z@tP:mRNA export from nucleussq~Z@tP:translational elongationsq~Z.@t(P:regulation of translational initiationsq~Z*@tP:inflammatory responsesq~Z@t P:mitosissq~ZJ@t!P:intracellular signaling cascadesq~Zc@tP:cell-cell signalingsq~Z|@tP:female gamete generationsq~Z$@tP:RNA modificationsq~Z?@tP:phosphorylationsq~ZJ@tP:viral genome replicationsq~Z @tP:leukocyte activationsq~Z@t/P:transcription from RNA polymerase II promotersq~Z @tF:protein bindingsq~Z2@tF:identical protein bindingsq~Zt@tF:transcription factor activitysq~ZQ@tF:microtubule bindingsq~Z@tF:nuclease activitysq~Z@t0F:translation factor activity, nucleic acid b...sq~Z@tF:O-methyltransferase activitysq~Z @tF:3'-5' exonuclease activitysq~Z@tF:mRNA 3'-UTR bindingsq~ZB@t*F:protein serine/threonine kinase activitysq~Z@tF:signal transducer activitysq~Z@tF:Toll bindingsq~Z@t F:GTP bindingsq~Z@t F:RNA bindingsq~Z@t C:nucleussq~Zi@t C:cytoplasmsq~Z$@t!C:interleukin-18 receptor complexsq~Z@t&C:proteasome complex (sensu Eukaryota)sq~Z@t C:microsomesq~Z@tC:soluble fractionsq~Zb@t C:nucleolussq~Z@t0C:eukaryotic translation elongation factor 1 ...sq~Z @t C:interleukin-1 receptor complexppxsq~uq~ sq~@t P:cell growtht16049sq~@t'P:DNA catabolic process, exonucleolytict738sq~@tP:RNA catabolic processt6401sq~@tP:RNA processingt6396sq~@tP:spermatogenesist7283sq~@t F:5'-3' exoribonuclease activityt4534sq~@tF:protein bindingt5515sq~@t C:nucleolust5730ppxsq~uq~ sq~@t IPR004859t Put_53exosq~@t IPR001878tZnf_CCHCppppppppxsq~uq~ sq~@tXRN_NtPF03159pppppppppxtQ9H0D6t XRN2_HUMANsq~uq~ sq~@tDHM1-like proteinsq~@t DHP proteinppppppppxt Homo sapienstBAT2sq~P?VuoD%tLarge proline-rich protein BAT2sq~uq~ sq~UDtENSG00000206318sq~UDtENSG00000206427ppppppppxsq~uq~ sq~mDtBAT2sq~mDtG2ppppppppxsq~;uq~ Psq~ZDt(P:nuclear mRNA splicing, via spliceosomesq~ZaDt!P:Ras protein signal transductionsq~ZDt$P:central nervous system developmentsq~ZcDtP:cell-cell signalingsq~Z.Dt(P:regulation of translational initiationsq~ZDt0P:G-protein coupled receptor protein signalin...sq~ZDt0P:epidermal growth factor receptor signaling ...sq~ZDtP:signal transductionsq~ZDt0P:mitotic cell cycle spindle assembly checkpointsq~Z+DtP:immune responsesq~ZDt P:excretionsq~ZODt P:protein amino acid methylationsq~ZDt$P:assembly of spliceosomal tri-snRNPsq~ZDtP:mRNA polyadenylationsq~Z9Dt"P:positive regulation of apoptosissq~ZDt+P:NLS-bearing substrate import into nucleussq~ZDtP:mRNA cleavagesq~ZDtP:nuclear importsq~ZDtP:RNA export from nucleussq~Z ^Dt$P:insulin receptor signaling pathwaysq~ZDtF:protein bindingsq~ZDt F:RNA bindingsq~ZDtF:nucleotide bindingsq~Z2DtF:identical protein bindingsq~Z KDtF:poly-glutamine tract bindingsq~Z#_DtF:electron carrier activitysq~Z(Dt$F:insulin receptor substrate bindingsq~ZDtF:mRNA 3'-UTR bindingsq~ZDtF:SH3/SH2 adaptor activitysq~ZDtF:signal transducer activitysq~ZBDt%F:G-protein coupled receptor activitysq~ZDtF:signal sequence bindingsq~Z0Dt,F:procollagen-proline 4-dioxygenase activitysq~Z"Dt*F:epidermal growth factor receptor bindingsq~ZpDt F:bindingsq~ZDt%F:ATP-dependent RNA helicase activitysq~ZDt(F:translation initiation factor activitysq~ZDt F:glutamine-tRNA ligase activitysq~ZqDtF:single-stranded DNA bindingsq~ZDtF:single-stranded RNA bindingsq~ZiDt C:cytoplasmsq~ZDt C:nucleussq~ZDtC:integral to plasma membranesq~Z1Dt C:spliceosomesq~ZwADtC:ribonucleoprotein complexsq~ZMDt C:flagellumsq~ZDt&C:proteasome complex (sensu Eukaryota)sq~ZwBDt0C:heterogeneous nuclear ribonucleoprotein com...sq~ZDt0C:mRNA cleavage and polyadenylation specifici...sq~ZDt C:cytosolsq~ZDtC:cytoskeletonsq~ZDtC:plasma membranesq~ZDtC:Golgi apparatussq~ZDt C:microsomesq~ZoDtC:mitochondrial inner membranesq~ZDt0C:eukaryotic translation initiation factor 3 ...sq~ZDt C:nucleoplasmsq~ZDtC:fibrinogen complexsq~Z?DtC:nuclear matrixpppppppppppppppppppppxsq~uq~ sq~DtF:protein bindingt5515pppppppppxsq~uq~ sq~Dt IPR009738tBAT2_Npppppppppxsq~uq~ sq~DtBAT2_NtPF07001pppppppppxtP48634t BAT2_HUMANsq~uq~ sq~DtHLA-B-associated transcript 2pppppppppxt Homo sapienstQ8N9S6sq~P?x07W8%tACDNA FLJ36605 fis, clone TRACH2015316, highly similar to VIMENTINsq~uq~ sq~UWtENSG00000026025pppppppppxpsq~nuq~ sq~ZWt,P:regulation of transcription, DNA-dependentsq~Z<WtP:protein homooligomerizationsq~ZWt P:transportsq~Z=WtP:protein complex assemblysq~ZGWt%P:protein amino acid ADP-ribosylationsq~ZlWt P:proteolysissq~ZWt(P:ER to Golgi vesicle-mediated transportsq~ZCWtP:response to oxidative stresssq~ZbWt*P:cytoskeleton organization and biogenesissq~ZWt0P:transcription from RNA polymerase III promotersq~ZWt/P:transcription from RNA polymerase II promotersq~ZWWt P:carbohydrate metabolic processsq~ZtWtP:DNA replicationsq~Z|Wt"P:DNA unwinding during replicationsq~ZWtP:mitotic recombinationsq~ZWt0P:establishment and/or maintenance of chromat...sq~ZWtP:transcription, DNA-dependentsq~ZWtP:meiotic recombinationsq~ZWt0P:regulation of transcription from RNA polyme...sq~ZlWtP:microtubule nucleationsq~ZWt P:mitosissq~ZWtP:signal transductionsq~ZHWt#P:barbed-end actin filament cappingsq~ZlWt!P:regulation of insulin secretionsq~Z]WtP:response to arsenicsq~ZuWt&P:positive regulation of transcriptionsq~ZxWtP:apical protein localizationsq~Z5Wt$P:intermediate filament organizationsq~ZWtP:regulation of mRNA stabilitysq~ZsWt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZWt*P:cytoplasmic sequestering of CFTR proteinsq~ZvWtP:keratinocyte differentiationsq~Zu_WtP:actin modificationsq~ZFWtP:peptide cross-linkingsq~Z%WtP:response to virussq~Z!WtP:apoptotic programsq~Z WtP:RNA splicingsq~Z [WtP:cell proliferationsq~ZdWtP:synaptic transmissionsq~ZǢWt%P:positive regulation of DNA ligationsq~Z&Wt.P:very-long-chain fatty acid metabolic processsq~ZWt0P:positive regulation of gene-specific transc...sq~ZWt0P:double-strand break repair via homologous r...sq~Z-Wt&P:epithelial to mesenchymal transitionsq~ZWtP:regulation of cell growthsq~ZWtF:protein bindingsq~ZtWtF:transcription factor activitysq~ZPWt(F:structural constituent of cytoskeletonsq~Z2WtF:identical protein bindingsq~Z NWtF:zinc ion bindingsq~ZqWtF:single-stranded DNA bindingsq~Z_WtF:transporter activitysq~Z@Wt"F:transcription activator activitysq~ZWt!F:transcription cofactor activitysq~ZWt F:RNA bindingsq~ZWt$F:transcription corepressor activitysq~ZWtF:mRNA 3'-UTR bindingsq~Z!ZWtF:proteasome activator activitysq~ZtWt0F:NAD(P)+-protein-arginine ADP-ribosyltransfe...sq~ZjWtF:double-stranded DNA bindingsq~ZWtF:recombinase activitysq~ZWtF:syntaxin-6 bindingsq~ZgWtF:myosin II bindingsq~ZWt/F:single-stranded DNA-dependent ATPase activitysq~ZWt0F:cystic fibrosis transmembrane conductance r...sq~ZwWtF:caspase activitysq~ZwWtF:protein binding, bridgingsq~Zw3WtF:snoRNA bindingsq~Z]Wt F:DNA bindingsq~ZVWtF:protein C-terminus bindingsq~ZWtF:motor activitysq~ZWtF:actin bindingsq~ZWtF:calcium ion bindingsq~ZpWt F:bindingsq~ZWtF:signal transducer activitysq~ZWt0F:mannosyl-oligosaccharide 1,3-1,6-alpha-mann...sq~ZWtF:fatty acid bindingsq~ZsWt+F:long-chain-fatty-acid-CoA ligase activitysq~Z6Wt*F:H3/H4 histone acetyltransferase activitysq~ZBWtF:GTP-Rho bindingsq~ZWt F:ATP bindingsq~Z Wt C:nucleussq~ZiWt C:cytoplasmsq~ZWtC:intermediate filamentsq~ZWt C:centrosomesq~Z>WtC:integral to membranesq~Z'WtC:keratin filamentsq~ZWtC:condensed nuclear chromosomesq~ZWt C:polysomesq~Z{WtC:apical cortexsq~ZWt&C:proteasome complex (sensu Eukaryota)sq~ZdWt+C:small nucleolar ribonucleoprotein complexsq~ZkWtC:mitochondrionsq~ZWtC:Golgi membranesq~ZoWtC:mitochondrial inner membranesq~ZWtC:cornified envelopesq~ZWtC:cytoskeletonsq~ZWtC:plus-end kinesin complexsq~Z= WtC:actin cytoskeletonsq~ZWtC:plasma membranesq~ZWtC:extracellular regionsq~ZuWt'C:trans-Golgi network transport vesiclesq~ZWtC:membrane fractionsq~ZWtC:soluble fractionsq~ZWtC:insoluble fractionsq~Z!YWtC:proteasome activator complexsq~Z#WtC:transcription factor complexsq~Z1Wt C:spliceosomesq~Z RWtC:gamma-tubulin ring complexsq~ZWt C:kinetochoreppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~WtF:structural molecule activityt5198sq~WtC:intermediate filamentt5882ppppppppxsq~uq~ sq~Wt IPR001664tIFsq~Wt IPR002957t Keratin_Ippppppppxsq~uq~ sq~WtFilamenttPF00038pppppppppxtQ8N9S6t Q8N9S6_HUMANpt Homo sapienstIKKEsq~P?u;LOPP%t:Inhibitor of nuclear factor kappa-B kinase subunit epsilonsq~uq~ sq~UPtENSG00000143466pppppppppxsq~uq~ sq~mPtIKBKEsq~mPtIKKEsq~mPtIKKIsq~mPtKIAA0151ppppppxsq~Puq~ sq~Z Pt P:translationsq~Z PtP:signal transductionsq~Z9 PtP:protein foldingsq~ZDPt$P:protein amino acid phosphorylationsq~ZoPt/P:ubiquitin-dependent protein catabolic processsq~ZJPtP:response to unfolded proteinsq~ZPtP:cell motilitysq~ZsPt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z [PtP:cell proliferationsq~ZtPtP:DNA replicationsq~ZPtP:anti-apoptosissq~ZJPt.P:regulation of progression through cell cyclesq~Z.Pt(P:regulation of translational initiationsq~Z=PtP:protein complex assemblysq~ZPt(P:nuclear mRNA splicing, via spliceosomesq~ZPt!P:intracellular protein transportsq~Z&PtP:response to stresssq~Z:PtP:protein transportsq~Z`Pt+P:small GTPase mediated signal transductionsq~ZPt0P:regulation of transcription from RNA polyme...sq~ZWPt P:carbohydrate metabolic processsq~ZPtP:induction of apoptosissq~ZPt/P:transcription from RNA polymerase II promotersq~ZPt P:DNA repairsq~ZPt P:cell cyclesq~ZPtP:tricarboxylic acid cyclesq~Z ^Pt$P:insulin receptor signaling pathwaysq~Z PtP:RNA splicingsq~ZPt0P:generation of precursor metabolites and energysq~Z>Pt P:cell growthsq~ZǔPt.P:activation of NF-kappaB transcription factorsq~Z@PtP:protein ubiquitinationsq~ZPtP:lipid metabolic processsq~ZPt,P:regulation of transcription, DNA-dependentsq~ZPt P:apoptosissq~ZPtP:nucleosome assemblysq~ZPt P:chemotaxissq~Z \Pt+P:positive regulation of cell proliferationsq~ZlPt P:proteolysissq~Z*PtP:inflammatory responsesq~ZPt P:endocytosissq~ZuPt0P:positive regulation of nitric oxide biosynt...sq~Zu`PtP:actin filament-based movementsq~Z!PtP:apoptotic programsq~ZPtP:nucleocytoplasmic transportsq~ZPt P:glycolysissq~Z]PtP:muscle developmentsq~ZPtP:caspase activationsq~ZJPt+P:N-terminal protein amino acid acetylationsq~ZPt/P:cotranslational protein targeting to membranesq~Z@PtP:protein modification processsq~ZFPt&P:protein amino acid dephosphorylationsq~ZGgPt0P:protein amino acid N-linked glycosylation v...sq~Z PtP:translational initiationsq~ZPtP:cell cycle arrestsq~ZPt$P:prostaglandin biosynthetic processsq~ZPt P:cytokinesissq~ZPt P:mitosissq~ZPtP:DNA recombinationsq~ZPtP:nervous system developmentsq~ZPtP:mRNA polyadenylationsq~ZPt0P:G-protein coupled receptor protein signalin...sq~ZPtP:RNA processingsq~ZPtP:mRNA processingsq~ZOPt0P:regulation of cyclin-dependent protein kina...sq~Z ]Pt+P:negative regulation of cell proliferationsq~ZPtP:electron transportsq~ZaPt!P:Ras protein signal transductionsq~ZEPt0P:positive regulation of transcription, DNA-d...sq~ZPt0P:nucleobase, nucleoside, nucleotide and nucl...sq~ZDPt0P:negative regulation of transcription, DNA-d...sq~ZPt(P:protein amino acid autophosphorylationsq~Z!`PtP:epidermis developmentsq~ZKPtP:protein kinase cascadesq~ZPt0P:cell surface receptor linked signal transdu...sq~ZPt0P:epidermal growth factor receptor signaling ...sq~ZhPtP:cytoskeletal anchoringsq~Z=Pt%P:integrin-mediated signaling pathwaysq~ZPtP:receptor-mediated endocytosissq~ZbPt*P:cytoskeleton organization and biogenesissq~ZYPt0P:chromosome organization and biogenesis (sen...sq~Z8PtP:cellular defense responsesq~ZPtP:cell communicationsq~ZiPtP:microtubule-based processsq~ZjPtP:microtubule-based movementsq~ZCPtP:response to oxidative stresssq~ZPt-P:mitotic spindle organization and biogenesissq~Z+PtP:immune responsesq~ZHPtP:ER-nuclear signaling pathwaysq~ZPt!P:mitotic chromosome condensationsq~Z PtP:membrane fusionsq~ZPtP:mitotic cell cycle checkpointsq~ZPtP:centrosome cyclesq~ZPt"P:regulation of muscle contractionsq~ZnPt%P:chaperonin-mediated tubulin foldingsq~ZRPt)P:activation of NF-kappaB-inducing kinasesq~ZPtP:Golgi to endosome transportsq~ZPtP:translational elongationsq~ZPtP:regulation of DNA repairsq~ZPtP:regulation of DNA replicationsq~ZuPtP:DNA-dependent DNA replicationsq~ZPtP:regulation of translationsq~ZaPtP:CTP biosynthetic processsq~Z8PtP:ATP catabolic processsq~Z-Pt$P:'de novo' IMP biosynthetic processsq~ZPtP:AMP biosynthetic processsq~ZPtP:purine ribonucleoside salvagesq~ZPt(P:purine nucleotide biosynthetic processsq~ZPtP:regulation of glycolysissq~ZPtP:postreplication repairsq~ZPtP:double-strand break repairsq~ZPtP:DNA modificationsq~ZPtP:snRNA export from nucleussq~ZPtP:RNA catabolic processsq~ZPtP:tRNA modificationsq~ZPt+P:transcription from mitochondrial promotersq~ZPtP:mRNA cleavagesq~ZPt0P:regulation of transcription from RNA polyme...sq~ZPtP:transcriptionsq~ZPtP:chromatin remodelingsq~ZPtP:nucleosome disassemblysq~ZPtP:DNA packagingsq~ZPt$P:DNA fragmentation during apoptosissq~ZPtP:fumarate metabolic processsq~ZPtP:citrate metabolic processsq~ZPtP:protein targetingsq~ZPt$P:protein targeting to mitochondrionsq~ZPtP:fatty acid beta-oxidationsq~ZPtP:ceramide metabolic processsq~ZPtP:ion transportsq~ZPtP:anion transportsq~ZPtP:chloride transportsq~ZPtP:mitochondrial transportsq~ZPtP:cellular iron ion homeostasissq~ZrPt(P:fructose 6-phosphate metabolic processsq~ZPt(P:ER to Golgi vesicle-mediated transportsq~ZPt!P:asparagine biosynthetic processsq~ZnPtP:ATP-dependent proteolysissq~ZmPt)P:membrane protein ectodomain proteolysissq~ZPt0P:tricarboxylic acid cycle intermediate metab...sq~ZPtP:inositol biosynthetic processsq~ZYPtP:glycogen metabolic processsq~ZPt-P:tRNA aminoacylation for protein translationsq~ZPtP:arginyl-tRNA aminoacylationsq~Z%PtP:tyrosyl-tRNA aminoacylationsq~Z1Pt)P:regulation of translational terminationsq~ZGPt%P:protein amino acid ADP-ribosylationsq~ZKPt)P:internal protein amino acid acetylationsq~ZOPt P:protein amino acid methylationsq~ZVPt"P:protein amino acid glycosylationsq~ZPt(P:intra-Golgi vesicle-mediated transportsq~ZxPtP:unfolded protein responsesq~ZPt)P:blood vessel endothelial cell migrationsq~ZPtP:cellular respirationsq~ZPtP:regulation of transcriptionsq~ZPt$P:regulation of cell differentiationsq~ZPt#P:positive regulation of DNA repairsq~ZxPt0P:positive regulation of transcription from R...sq~ZPt0P:positive regulation of dopamine metabolic p...sq~ZPt P:hypoxanthine metabolic processsq~ZPt0P:positive regulation of RNA export from nucleussq~ZPt%P:vesicle transport along microtubulesq~Z Pt0P:positive regulation of T cell cytokine prod...sq~Z-Pt&P:epithelial to mesenchymal transitionsq~ZPtP:histone exchangesq~ZPt$P:negative regulation of DNA bindingsq~ZPt0P:positive regulation of gene-specific transc...sq~ZxPt-P:retrograde protein transport, ER to cytosolsq~ZyRPt-P:positive regulation of histone modificationsq~ZPt+P:natural killer cell mediated cytotoxicitysq~ZyPt0P:negative regulation of microtubule polymeri...sq~Z{,Pt#P:actin cytoskeleton reorganizationsq~ZPt,P:negative regulation of histone acetylationsq~Z*PtP:protein refoldingsq~ZPtP:ribosome assemblysq~ZPtP:response to drugsq~ZPt0P:negative regulation of tyrosine phosphoryla...sq~ZPt%P:regulation of macrophage activationsq~Z:Pt"P:negative regulation of apoptosissq~Z PtP:blastocyst developmentsq~ZPt+P:mitochondrion transport along microtubulesq~ZPt0P:insulin-like growth factor receptor signali...sq~ZPt0P:microtubule cytoskeleton organization and b...sq~ZPtP:protein polyubiquitinationsq~ZPtP:inactivation of MAPK activitysq~ZPt0P:mRNA catabolic process, nonsense-mediated d...sq~Z>PtP:protein tetramerizationsq~ZHPt&P:positive regulation of cell motilitysq~ZYPtP:protein homotetramerizationsq~ZZPtP:protein heterotetramerizationsq~ZdPt/P:spindle pole body organization and biogenesissq~ZRPt'P:G1/S transition of mitotic cell cyclesq~ZKPtP:cell cycle checkpointsq~ZPt0P:positive regulation of ubiquitin ligase act...sq~ZhPt0P:cis assembly of U2-type pre-catalytic splic...sq~ZPt)P:nuclear mRNA 3'-splice site recognitionsq~ZfPtP:regulation of secretionsq~ZPt%P:phosphoinositide-mediated signalingsq~ZPtP:angiogenesissq~ZPtP:skeletal developmentsq~ZcPt'P:plasma membrane to endosome transportsq~ZPtP:mRNA stabilizationsq~ZƤPt#P:T cell receptor signaling pathwaysq~ZƶPt*P:positive regulation of T cell activationsq~ZPtP:leukocyte migrationsq~ZFPtP:actin filament severingsq~ZIPt!P:actin filament bundle formationsq~ZPt$P:DNA double-strand break processingsq~ZPtP:telomere maintenancesq~ZPt0P:ribosomal small subunit assembly and mainte...sq~ZwPtP:maturation of SSU-rRNAsq~ZUPt'P:cytoplasmic sequestering of NF-kappaBsq~ZPt.P:actin polymerization and/or depolymerizationsq~Z Pt P:histone mRNA metabolic processsq~Z PtP:regulation of cell shapesq~Z!Pt%P:caspase activation via cytochrome csq~Z!Pt#P:phospholipid biosynthetic processsq~Z#Pt"P:purine base biosynthetic processsq~Z#Pt.P:ribonucleoside diphosphate catabolic processsq~Z$ZPtP:protein secretionsq~Z&PtP:organ morphogenesissq~Z'Pt$P:response to extracellular stimulussq~Z=5PtP:gas transportsq~Z=PtP:adenine transportsq~Z>@PtP:coenzyme A metabolic processsq~ZPtP:metabolic processsq~ZPt P:behaviorsq~ZPtP:sensory perception of soundsq~ZVPt P:JNK cascadesq~ZcPtP:cell-cell signalingsq~ZdPtP:synaptic transmissionsq~ZePtP:neurotransmitter secretionsq~ZkPt&P:multicellular organismal developmentsq~ZsPtP:spermatogenesissq~ZPtP:brain developmentsq~Z?@PtP:vesicle-mediated transportsq~Z_PtP:striated muscle developmentsq~ZPt P:cell agingsq~ZPtP:blood coagulationsq~ZPtP:visual perceptionsq~Z'1PtP:response to organic substancesq~Z>PtP:mRNA metabolic processsq~Z?JPt+P:regulation of striated muscle developmentsq~ZuaPtP:muscle filament slidingsq~ZuPtP:protein repairsq~ZuPt.P:regulation of Wnt receptor signaling pathwaysq~ZuPtP:cell differentiationsq~ZuPtP:regulation of cell adhesionsq~ZuPtP:neuron differentiationsq~ZvPtP:keratinocyte differentiationsq~Zv PtP:erythrocyte differentiationsq~Zv PtP:platelet formationsq~ZvPtP:monocyte differentiationsq~ZvdPt$P:negative regulation of cell growthsq~ZvzPt0P:DNA damage response, signal transduction by...sq~ZMPt%P:second-messenger-mediated signalingsq~ZKPt"P:leukotriene biosynthetic processsq~Z@aPt&P:negative regulation of transcriptionsq~Z@PtP:chromatin modificationsq~Z@PtP:histone ubiquitinationsq~Z#[Pt+P:pentose-phosphate shunt, oxidative branchsq~ZFPtP:peptide cross-linkingsq~ZvPt)P:ER-associated protein catabolic processsq~ZKgPtP:D-ribose catabolic processsq~ZKPt0P:cytokine and chemokine mediated signaling p...sq~ZPtF:protein bindingsq~ZPt F:RNA bindingsq~ZPt$F:structural constituent of ribosomesq~ZNJ PtF:unfolded protein bindingsq~Z PtF:signal transducer activitysq~Z Pt F:ATP bindingsq~ZTPtF:GTPase activitysq~ZtPtF:transcription factor activitysq~Z2PtF:identical protein bindingsq~ZPtF:actin bindingsq~ZAPtF:ATPase activitysq~Z3Pt#F:protein homodimerization activitysq~ZPPt(F:structural constituent of cytoskeletonsq~ZPt(F:translation initiation factor activitysq~Z]Pt F:DNA bindingsq~ZPt%F:protein heterodimerization activitysq~ZPt F:GTP bindingsq~ZBPt*F:protein serine/threonine kinase activitysq~ZPt$F:transcription coactivator activitysq~Z NPtF:zinc ion bindingsq~ZoPtF:enzyme activator activitysq~ZVPtF:protein C-terminus bindingsq~ZPt#F:ubiquitin-protein ligase activitysq~ZGPtF:actin filament bindingsq~Z(Pt$F:insulin receptor substrate bindingsq~Z#_PtF:electron carrier activitysq~ZwPtF:protein binding, bridgingsq~ZNPtF:structural molecule activitysq~Z_PtF:transporter activitysq~ZPtF:microtubule motor activitysq~ZPt%F:ATP-dependent RNA helicase activitysq~ZxPtF:TPR domain bindingsq~Z JPtF:poly(U) bindingsq~ZMPtF:enzyme bindingsq~ZvPt*F:nitric-oxide synthase regulator activitysq~ZPt&F:protein disulfide isomerase activitysq~ZPtF:poly(A) bindingsq~ZQPtF:microtubule bindingsq~ZPt%F:ATP-dependent DNA helicase activitysq~ZpPt F:bindingsq~ZxPtF:steroid bindingsq~ZPtF:cytokine activitysq~ZPtF:signal sequence bindingsq~ZOPtF:endopeptidase activitysq~ZPtF:receptor bindingsq~ZPtF:enoyl-CoA hydratase activitysq~ZvPt0F:RNA polymerase II transcription factor acti...sq~ZPt0F:translation factor activity, nucleic acid b...sq~ZY<Pt&F:voltage-gated anion channel activitysq~ZPt%F:translation release factor activitysq~ZPt$F:transcription corepressor activitysq~ZsPtF:NF-kappaB bindingsq~ZPt!F:transcription cofactor activitysq~Z}PtF:protein N-terminus bindingsq~ZPtF:mRNA bindingsq~Z@PtF:protein kinase activitysq~Z!Pt0F:protein phosphatase type 2A regulator activitysq~ZPt#F:phosphoinositide 3-kinase bindingsq~Z1PtF:tRNA bindingsq~Z!PtF:cytochrome-c oxidase activitysq~ZPtF:creatine kinase activitysq~ZPt#F:aminoacyl-tRNA hydrolase activitysq~ZPt0F:asparagine synthase (glutamine-hydrolyzing)...sq~ZPt%F:carbonyl reductase (NADPH) activitysq~Z?PPt F:AMP bindingsq~ZGPtF:dopachrome isomerase activitysq~ZPtF:aldehyde reductase activitysq~ZPt$F:adenylosuccinate synthase activitysq~Z:Pt(F:ion transmembrane transporter activitysq~ZQPtF:phosphorylase kinase activitysq~Z#Pt0F:phosphoribosylaminoimidazolecarboxamide for...sq~Z"Pt0F:phosphoribosylformylglycinamidine synthase ...sq~ZPtF:histone bindingsq~ZPtF:lysophospholipase activitysq~Z Pt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZPtF:peroxidase activitysq~ZPt(F:inositol-3-phosphate synthase activitysq~Z@kPtF:oxidoreductase activitysq~ZPtF:fumarate hydratase activitysq~ZFPt0F:hypoxanthine phosphoribosyltransferase acti...sq~ZBPt$F:nucleoside-triphosphatase activitysq~ZBPtF:poly(rC) bindingsq~ZEPt-F:hydroxymethylglutaryl-CoA synthase activitysq~Z"PtF:helicase activitysq~Z7PtF:histone deacetylase activitysq~ZKPtF:nucleoside kinase activitysq~ZkPt"F:L-lactate dehydrogenase activitysq~ZMPtF:syntaxin bindingsq~ZPtF:epoxide hydrolase activitysq~Z}Pt"F:ubiquitin thiolesterase activitysq~Z~PtF:metalloendopeptidase activitysq~Z@Pt"F:transcription activator activitysq~Z@Pt-F:specific transcriptional repressor activitysq~Z~Pt)F:methionine adenosyltransferase activitysq~ZnPt#F:lactoylglutathione lyase activitysq~ZNEPtF:heme bindingsq~ZMPtF:chemokine bindingsq~ZJPt"F:ADP-sugar diphosphatase activitysq~ZʧPtF:Hsp90 protein bindingsq~Z^PtF:DNA helicase activitysq~ZqPtF:single-stranded DNA bindingsq~Z{Pt#F:steroid hormone receptor activitysq~ZPtF:telomerase activitysq~ZPtF:RNA helicase activitysq~ZcPt0F:electron transporter, transferring electron...sq~ZePtF:protein self-associationsq~Z'PtF:insulin bindingsq~ZPt(F:translation elongation factor activitysq~Z Pt F:ADP bindingsq~ZPtF:protein anchorsq~ZPtF:metal ion bindingsq~ZaPt0F:minus-end directed microfilament motor acti...sq~Z\PtF:nucleic acid bindingsq~ZPtF:PTB domain bindingsq~ZhPt"F:succinate dehydrogenase activitysq~ZPtF:microfilament motor activitysq~ZWPt F:NAD bindingsq~ZPtF:magnesium ion bindingsq~ZǏPtF:chaperone bindingsq~ZSPtF:RNA cap bindingsq~ZuPtF:ADP reductase activitysq~ZBPtF:microtubule plus-end bindingsq~Z,Pt#F:prostaglandin-E synthase activitysq~ZgPtF:beta-tubulin bindingsq~ZPt.F:peptidyl-prolyl cis-trans isomerase activitysq~ZzPtF:ubiquitin bindingsq~ZPtF:motor activitysq~Z|Pt*F:N-terminal myristoylation domain bindingsq~Z{Pt"F:ubiquitin protein ligase bindingsq~ZbPtF:IMP dehydrogenase activitysq~ZyPt0F:RNA splicing factor activity, transesterifi...sq~ZnPt&F:NAD+ ADP-ribosyltransferase activitysq~ZPt)F:acetyl-CoA C-acetyltransferase activitysq~ZPtF:acid phosphatase activitysq~ZPt,F:adenine phosphoribosyltransferase activitysq~ZxPtF:Tat protein bindingsq~ZxPt!F:actin-dependent ATPase activitysq~Zv{PtF:estrogen receptor bindingsq~Z~PtF:MutLalpha complex bindingsq~ZaPtF:IMP cyclohydrolase activitysq~ZPtF:phosphoinositide bindingsq~ZPtF:antigen bindingsq~ZPtF:ribosome bindingsq~ZPtF:ATP-dependent protein bindingsq~ZPt*F:3-hydroxyacyl-CoA dehydrogenase activitysq~Z Pt F:6-phosphofructokinase activitysq~ZPtF:ATPase activity, coupledsq~Z&PtF:ATP citrate synthase activitysq~Z+PtF:CTP synthase activitysq~Z0PtF:MHC class I protein bindingsq~Z;Pt&F:DNA-directed RNA polymerase activitysq~ZPtF:SH2 domain bindingsq~ZPtF:adenylate kinase activitysq~Z`Pt$F:NF-kappaB-inducing kinase activitysq~ZPtF:calmodulin bindingsq~ZZPt!F:ATP-dependent helicase activitysq~ZPtF:N-acetyltransferase activitysq~ZPtF:cytoskeletal protein bindingsq~ZPtF:transcription factor bindingsq~ZPt'F:nuclear localization sequence bindingsq~ZPt#F:protein kinase inhibitor activitysq~ZPt"F:phospholipase inhibitor activitysq~ZQPtF:GMP synthase activitysq~Z )PtF:peptidase activitysq~Z *Pt"F:cysteine-type peptidase activitysq~ZPt&F:ubiquitin activating enzyme activitysq~ZPtF:tyrosine-tRNA ligase activitysq~ZPtF:lysine-tRNA ligase activitysq~Z"Pt*F:epidermal growth factor receptor bindingsq~ZPt0F:cyclin-dependent protein kinase inhibitor a...sq~ZPt(F:protein phosphatase inhibitor activitysq~ZPtF:calcium ion bindingsq~ZPtF:fatty acid bindingsq~ZPtF:chloride channel activitysq~ZPt0F:UDP-glucose:glycoprotein glucosyltransferas...sq~ZPtF:FK506 bindingsq~ZPt$F:insulin-like growth factor bindingsq~Z!Pt F:interleukin-8 receptor bindingsq~ZPt%F:GDP-dissociation inhibitor activitysq~ZPtF:SH3/SH2 adaptor activitysq~ZPt0F:transmembrane receptor protein tyrosine kin...sq~ZPtF:scavenger receptor activitysq~ZPt.F:insulin-like growth factor receptor activitysq~ZPtF:insulin receptor activitysq~ZPtF:transferrin receptor activitysq~Z sPt"F:structural constituent of musclesq~Z xPtF:7S RNA bindingsq~Z!XPtF:Ran GTPase bindingsq~ZPtF:transketolase activitysq~ZoPt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~ZPtF:transaldolase activitysq~ZrPt/F:protein serine/threonine phosphatase activitysq~ZPt0F:pyruvate dehydrogenase (acetyl-transferring...sq~ZPt/F:ribonucleoside-diphosphate reductase activitysq~Z{Pt*F:purine-nucleoside phosphorylase activitysq~ZPtF:spermidine synthase activitysq~Z!PtF:pyridoxal kinase activitysq~ZPtF:glycine-tRNA ligase activitysq~ZPt F:glutamine-tRNA ligase activitysq~ZPt!F:asparagine-tRNA ligase activitysq~ZcPtF:MAP kinase activitysq~Z!.Pt F:translation activator activitysq~ZiPt"F:protein-tyrosine kinase activitysq~ZlPt0F:receptor signaling protein tyrosine kinase ...sq~Z Pt.F:3'(2'),5'-bisphosphate nucleotidase activitysq~Zi'Pt C:cytoplasmsq~Z$Pt C:nucleussq~ZPt&C:proteasome complex (sensu Eukaryota)sq~Z PtC:soluble fractionsq~Z Pt C:cytosolsq~Zk PtC:mitochondrionsq~ZPtC:integral to plasma membranesq~ZPtC:endoplasmic reticulumsq~ZPtC:intracellularsq~ZPtC:plasma membranesq~ZbPt C:nucleolussq~ZPt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZWPt!C:perinuclear region of cytoplasmsq~ZPtC:cytoskeletonsq~ZPtC:membrane fractionsq~Z>Pt C:membranesq~Z>PtC:integral to membranesq~ZPt C:centrosomesq~ZPtC:extracellular spacesq~Z1Pt C:spliceosomesq~ZPt0C:proteasome regulatory particle (sensu Eukar...sq~ZPtC:mitochondrial matrixsq~ZPt C:endoplasmic reticulum membranesq~ZPt%C:protein phosphatase type 2A complexsq~ZPtC:rufflesq~ZmPtC:mitochondrial outer membranesq~Z'PtC:cell surfacesq~ZPtC:paraspecklessq~ZPtC:endoplasmic reticulum lumensq~Z>Pt$C:cytoplasmic membrane-bound vesiclesq~ZPt C:kinetochoresq~ZPt0C:eukaryotic translation elongation factor 1 ...sq~Z6Pt C:snRNP U2sq~ZPt0C:eukaryotic translation initiation factor 3 ...sq~Z@MPtC:unconventional myosin complexsq~Z?Pt0C:eukaryotic translation initiation factor 4F...sq~ZPtC:kinesin complexsq~ZPtC:late endosomesq~ZPt C:endosomesq~ZPtC:stress fibersq~ZPt C:spectrinsq~Z :Pt$C:oligosaccharyl transferase complexsq~ZPt C:microtubulesq~ZPtC:protein complexsq~Z bPt!C:F-actin capping protein complexsq~ZPt+C:proteasome core complex (sensu Eukaryota)sq~Z= PtC:actin cytoskeletonsq~ZPtC:extracellular regionsq~ZPt C:lysosomesq~ZwAPtC:ribonucleoprotein complexsq~Z}PtC:cleavage furrowsq~ZPt#C:ER-Golgi intermediate compartmentsq~ZPtC:nuclear envelopesq~ZPt(C:NuA4 histone acetyltransferase complexsq~Z2Pt C:cell cortexsq~ZPtC:cornified envelopesq~ZPtC:contractile ringsq~Z?PtC:prefoldin complexsq~Z@Pt,C:DNA-directed RNA polymerase II, holoenzymesq~ZPt C:ribosomesq~Z@PtC:SWI/SNF complexsq~ZPt C:microvillussq~ZRPtC:pore complexsq~ZPtC:condensin complexsq~Z9PtC:6-phosphofructokinase complexsq~ZPtC:brush bordersq~ZvPtC:histone deacetylase complexsq~ZPtC:actin filamentsq~ZPtC:ubiquitin ligase complexsq~Z=PtC:microtubule cytoskeletonsq~ZPtC:condensed nuclear chromosomesq~ZPtC:dynactin complexsq~ZPt"C:muscle thin filament tropomyosinsq~Z PtC:chromosome, telomeric regionsq~ZPt C:chromatinsq~ZPt C:nucleosomesq~ZPtC:mRNA cleavage factor complexsq~ZPt C:polysomesq~Z$PtC:citrate lyase complexsq~ZPtC:synaptonemal complexsq~ZPtC:trans-Golgi networksq~ZPt C:spindlesq~ZPt"C:DNA replication factor C complexsq~ZPt0C:nuclear envelope-endoplasmic reticulum networksq~Z#PtC:transcription factor complexsq~Z.PtC:chromatin assembly complexsq~ZuPt'C:trans-Golgi network transport vesiclesq~ZyPt#C:cortical microtubule cytoskeletonsq~Z2Pt C:snRNP U5sq~ZAPtC:telomerase holoenzyme complexsq~ZPt C:nucleoplasmsq~Z@KPtC:myosin complexsq~ZzPt&C:ubiquitin conjugating enzyme complexsq~ZzPtC:UBC13-MMS2 complexsq~ZxPtC:cortical cytoskeletonsq~ZSPt.C:ribonucleoside-diphosphate reductase complexsq~Z|PtC:filamentous actinsq~ZwBPt0C:heterogeneous nuclear ribonucleoprotein com...sq~Z|PtC:mitochondrial membranesq~Zw Pt C:midbodysq~ZuPtC:transport vesiclesq~ZuPtC:AP-1 adaptor complexsq~ZPt C:peroxisomesq~ZMPtC:extrinsic to membranesq~ZPt0C:signal recognition particle, endoplasmic re...sq~ZPtC:rough endoplasmic reticulumsq~ZPt C:microsomesq~ZPtC:Golgi apparatussq~ZPt C:Golgi stacksq~Z@Pt C:PML bodysq~ZPtC:early endosomesq~ZPt C:signalosomesq~ZuPtC:clathrin coatsq~Z|PtC:nuclear membranesq~ZoPtC:mitochondrial inner membranesq~ZuPt,C:mitochondrial respiratory chain complex IIsq~ZyPt0C:mitochondrial proton-transporting ATP synth...sq~Z~Pt#C:mitochondrial intermembrane spacesq~ZPtC:mitochondrial ribosomesq~ZPt'C:mitochondrial large ribosomal subunitsq~ZxPt&C:rough endoplasmic reticulum membraneppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~PtP:immune responset6955sq~Pt0P:positive regulation of I-kappaB kinase/NF-k...t43123sq~Pt$P:protein amino acid phosphorylationt6468sq~Pt F:ATP bindingt5524sq~Pt$F:NF-kappaB-inducing kinase activityt4704sq~PtF:protein bindingt5515sq~Pt C:cytoplasmt5737pppxsq~uq~ sq~Pt IPR000719tProt_kinase_coresq~Pt IPR008271tSer_thr_pkin_ASppppppppxsq~uq~ sq~PtPkinasetPF00069pppppppppxtQ14164t IKKE_HUMANsq~uq~ sq~PtI kappa-B kinase epsilonsq~PtIkBKEsq~Pt IKK-epsilonsq~PtIKK-Esq~PtInducible I kappa-B kinasesq~PtIKK-ippppxt Homo sapienstFBRLsq~P?xM3/&/%t'rRNA 2'-O-methyltransferase fibrillarinsq~uq~ sq~U&tENSG00000105202pppppppppxsq~uq~ sq~m&tFBLsq~m&tFIB1sq~m&tFLRNpppppppxsq~uq~ sq~Z&tP:anti-apoptosissq~Zs&t0P:positive regulation of I-kappaB kinase/NF-k...sq~Z&tP:signal transductionsq~Z [&tP:cell proliferationsq~Z \&t+P:positive regulation of cell proliferationsq~ZJ&tP:response to unfolded proteinsq~Z&tP:cell motilitysq~Z&tP:RNA processingsq~Zu&t0P:positive regulation of nitric oxide biosynt...sq~Z*&tP:inflammatory responsesq~Zǔ&t.P:activation of NF-kappaB transcription factorsq~Z&t,P:regulation of transcription, DNA-dependentsq~Z &t P:translationsq~Z+&tP:immune responsesq~Zi&tP:microtubule-based processsq~ZO&t P:protein amino acid methylationsq~Z&tP:chromosome segregationsq~Z&t P:mitosissq~Z&tP:regulation of mitosissq~Z&t0P:traversing start control point of mitotic c...sq~Z&tP:induction of apoptosissq~Z8&tP:cellular defense responsesq~Z&t0P:regulation of transcription from RNA polyme...sq~Zo&t/P:ubiquitin-dependent protein catabolic processsq~Z&tP:mitochondrial transportsq~Z&t!P:intracellular protein transportsq~Z&tP:nucleocytoplasmic transportsq~Z&t P:apoptosissq~ZD&t$P:protein amino acid phosphorylationsq~Z=&tP:protein complex assemblysq~Z9&tP:protein foldingsq~Z&&tP:response to stresssq~Z&tP:centrosome cyclesq~Z&tP:cell-matrix adhesionsq~Z*&tP:protein refoldingsq~Zt&tP:B cell proliferationsq~Z&tP:ribosome assemblysq~Z&t+P:natural killer cell mediated cytotoxicitysq~Z&t(P:regulation of protein homodimerizationsq~Z&t*P:regulation of protein heterodimerizationsq~Z&tP:vesicle localizationsq~Z&t$P:negative regulation of endocytosissq~ZE&t0P:positive regulation of transcription, DNA-d...sq~Z6&t0P:regulation of mitochondrial membrane permea...sq~Z&t!P:gastrulation (sensu Vertebrata)sq~Z&t!P:peptidyl-arginine N-methylationsq~Zu&tP:platelet activationsq~ZK&t0P:cytokine and chemokine mediated signaling p...sq~Z&t0P:cell surface receptor linked signal transdu...sq~Z=&t%P:integrin-mediated signaling pathwaysq~Z&t P:cell agingsq~Z&tP:sensory perception of soundsq~Z ]&t+P:negative regulation of cell proliferationsq~Z &tP:RNA splicingsq~Z!&t0P:induction of apoptosis by extracellular sig...sq~Z'1&tP:response to organic substancesq~Z'&tP:response to UV-Bsq~Z(&t0P:establishment and/or maintenance of transme...sq~Z>&t P:cell growthsq~Zɗ&tP:defense response to virussq~Z&t/P:transcription from RNA polymerase II promotersq~Z&tP:rRNA processingsq~Zʩ&t0P:regulation of mitochondrial membrane potentialsq~Z&tP:spliceosome assemblysq~ZV&t'P:G2/M transition of mitotic cell cyclesq~Z,&t+P:release of cytochrome c from mitochondriasq~Zz&tP:DNA ligationsq~Z&tP:regulation of DNA replicationsq~Z&t0P:double-strand break repair via nonhomologou...sq~Z&tP:chromatin remodelingsq~Z&t0P:regulation of transcription from RNA polyme...sq~Z&tP:skeletal developmentsq~Z&tF:protein bindingsq~Z&t F:RNA bindingsq~Z2&tF:identical protein bindingsq~Z3&t#F:protein homodimerization activitysq~ZM&tF:enzyme bindingsq~Zv&t*F:nitric-oxide synthase regulator activitysq~Zx&tF:TPR domain bindingsq~Z&tF:RNA helicase activitysq~Z]&t F:DNA bindingsq~Z&t F:ATP bindingsq~Z&t$F:transcription coactivator activitysq~Zs&tF:NF-kappaB bindingsq~Z&tF:signal transducer activitysq~Z&t%F:protein heterodimerization activitysq~Z{&t#F:RNA-3'-phosphate cyclase activitysq~ZM&tF:protein kinase bindingsq~Zw@&t"F:transcription regulator activitysq~Z&t%F:ATP-dependent RNA helicase activitysq~Z&t%F:ATP-dependent DNA helicase activitysq~Z@&tF:protein kinase activitysq~ZO&tF:endopeptidase activitysq~Zx&tF:Tat protein bindingsq~Z&t(F:translation initiation factor activitysq~ZS&tF:RNA cap bindingsq~ZNJ&tF:unfolded protein bindingsq~Z}&tF:protein N-terminus bindingsq~Zj&tF:double-stranded DNA bindingsq~Zy&t0F:RNA polymerase II transcription factor acti...sq~Zu&t0F:RNA polymerase I transcription factor activitysq~Z"&tF:helicase activitysq~Z0&tF:MHC class I protein bindingsq~Z&t$F:structural constituent of ribosomesq~Z=&tF:phosphate bindingsq~ZB&t*F:protein serine/threonine kinase activitysq~Z&tF:methyltransferase activitysq~Z&tF:mRNA bindingsq~ZP&t(F:structural constituent of cytoskeletonsq~Z&t!F:transmembrane receptor activitysq~Z_&tF:transporter activitysq~Z&t0F:translation factor activity, nucleic acid b...sq~Z&tF:RNA-dependent ATPase activitysq~Z&tF:receptor activitysq~Z&tF:cytoskeletal protein bindingsq~Z&tF:N-acetyltransferase activitysq~ZU&t*F:cyclin-dependent protein kinase activitysq~Z&t F:GTP bindingsq~Z&tF:N-methyltransferase activitysq~Zi &t C:cytoplasmsq~Zb&t C:nucleolussq~Z&t C:nucleussq~Z&tC:cytoskeletonsq~Z#&tC:transcription factor complexsq~Z&t C:microvillussq~Z|&tC:filamentous actinsq~Z&tC:plasma membranesq~Z?&tC:lateral plasma membranesq~Z&tC:mitochondrial matrixsq~Z&t C:centrosomesq~Zk&tC:mitochondrionsq~Z&t0C:eukaryotic translation initiation factor 3 ...sq~Z&tC:brush bordersq~Z&t C:cytosolsq~ZR&tC:pore complexsq~Z&tC:integral to plasma membranesq~Z&t C:microtubulesq~Z&t0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z&t+C:proteasome core complex (sensu Eukaryota)sq~Zc&tC:nucleolus organizer regionsq~Z>&t C:membranesq~Z>&tC:integral to membranesq~Z?&tC:basolateral plasma membranesq~Z@M&tC:unconventional myosin complexsq~Z?&t0C:eukaryotic translation initiation factor 4F...sq~Z:&t C:Cajal bodysq~ZwA&tC:ribonucleoprotein complexsq~ZwD&t)C:small nuclear ribonucleoprotein complexsq~Z&t(C:NuA4 histone acetyltransferase complexsq~Zx&tC:cortical actin cytoskeletonsq~Z&tC:membrane fractionsq~Z&t C:nucleoplasmsq~Z1&t C:spliceosomesq~Z&&tC:basal plasma membraneppppppxsq~uq~ sq~&tP:rRNA processingt6364sq~&tF:protein bindingt5515sq~&t F:RNA bindingt3723pppppppxsq~uq~ sq~&t IPR000692t Fibrillarinpppppppppxsq~uq~ sq~&t FibrillarintPF01269pppppppppxtP22087t FBRL_HUMANsq~uq~ sq~&t$34 kDa nucleolar scleroderma antigenpppppppppxt Homo sapienstHUS1sq~P?333333P%tCheckpoint protein HUS1sq~uq~ sq~UPtENSG00000136273pppppppppxsq~uq~ sq~mPtHUS1pppppppppxsq~9uq~ Psq~ZPt P:DNA repairsq~ZMPtP:DNA damage checkpointsq~ZLPtP:DNA replication checkpointsq~ZPt%P:phosphoinositide-mediated signalingsq~ZPtP:anti-apoptosissq~ZtPtP:DNA replicationsq~ZYPtP:protein homotetramerizationsq~Z9PtP:protein foldingsq~ZPtP:double-strand break repairsq~ZuPtP:DNA-dependent DNA replicationsq~ZPtP:purine ribonucleoside salvagesq~ZPtP:mitotic cell cycle checkpointsq~ZPtP:meiotic prophase Isq~ZPtP:signal transductionsq~ZPt P:behaviorsq~Z [PtP:cell proliferationsq~Z%PtP:UV protectionsq~Z@PtP:chromatin modificationsq~Z} Pt/P:regulation of ARF protein signal transductionsq~ZPt0P:positive regulation of dopamine metabolic p...sq~ZPt P:hypoxanthine metabolic processsq~ZPt(P:purine nucleotide biosynthetic processsq~ZPt P:glycolysissq~ZpPtP:fructose metabolic processsq~ZUPtP:regulation of phosphorylationsq~ZJPt.P:regulation of progression through cell cyclesq~ZPtF:protein bindingsq~Z PtF:3'-5' exonuclease activitysq~ZPtF:transcription factor bindingsq~ZdPtF:damaged DNA bindingsq~Z PtF:5'-3' exonuclease activitysq~ZBPtF:SH3 domain bindingsq~ZMPtF:enzyme bindingsq~ZMPtF:protein kinase bindingsq~Z~PtF:MutLalpha complex bindingsq~ZjPtF:double-stranded DNA bindingsq~Z2PtF:identical protein bindingsq~Z3Pt#F:protein homodimerization activitysq~ZJPtF:histone deacetylase bindingsq~ZPtF:magnesium ion bindingsq~ZBPtF:5'-flap endonuclease activitysq~ZtPtF:transcription factor activitysq~ZFPt0F:hypoxanthine phosphoribosyltransferase acti...sq~ZPt0F:ARF guanyl-nucleotide exchange factor activitysq~ZPtF:ribonuclease H activitysq~Z7PtF:histone deacetylase activitysq~ZPt)F:fructose-bisphosphate aldolase activitysq~ZQPtF:microtubule bindingsq~Z2PtF:beta DNA polymerase activitysq~Z uPt0F:double-stranded DNA specific exodeoxyribonu...sq~ZiPt C:cytoplasmsq~ZPt C:nucleussq~ZvPtC:histone deacetylase complexsq~ZPt&C:proteasome complex (sensu Eukaryota)sq~ZPtC:intracellularsq~ZPtC:spindle microtubulesq~ZPt"C:DNA replication factor C complexpppppppppppppppppppppppxsq~uq~ sq~PtP:DNA damage checkpointt77sq~Pt P:DNA repairt6281sq~PtF:protein bindingt5515sq~Pt C:nucleust5634ppppppxsq~uq~ sq~Pt IPR007150tHus1pppppppppxsq~uq~ sq~PtHus1tPF04005pppppppppxtO60921t HUS1_HUMANsq~uq~ sq~PthHUS1pppppppppxt Homo sapienstTFE3sq~P?&Z[*Q9+%tTranscription factor E3sq~uq~ sq~UQ9tENSG00000068323pppppppppxsq~uq~ sq~mQ9tTFE3pppppppppxsq~zuq~ sq~ZtQ9tP:DNA replicationsq~Z [Q9tP:cell proliferationsq~ZoQ9t/P:ubiquitin-dependent protein catabolic processsq~ZQ9tP:nucleosome assemblysq~ZQ9t,P:regulation of transcription, DNA-dependentsq~Z.Q9t(P:regulation of translational initiationsq~Z|Q9t"P:DNA unwinding during replicationsq~ZQ9t$P:base-excision repair, DNA ligationsq~Z8Q9tP:ATP catabolic processsq~ZQ9tP:DNA recombinationsq~Z-Q9t$P:'de novo' IMP biosynthetic processsq~ZQ9tP:citrate metabolic processsq~ZWQ9t P:carbohydrate metabolic processsq~ZQ9tP:cell cycle arrestsq~ZQ9tP:anti-apoptosissq~ZQ9tP:signal transductionsq~Z Q9t0P:transforming growth factor beta receptor si...sq~ZQ9tP:SMAD protein complex assemblysq~ZQ9t&P:establishment of blood-nerve barriersq~Z&Q9tP:response to stresssq~ZQ9t0P:establishment and/or maintenance of chromat...sq~ZQ9tP:nucleosome disassemblysq~ZQ9tP:nucleocytoplasmic transportsq~ZQ9t!P:intracellular protein transportsq~ZQ9tP:fatty acid beta-oxidationsq~ZQ9tP:polyamine metabolic processsq~ZQ9tP:methionine metabolic processsq~ZFQ9t&P:protein amino acid dephosphorylationsq~ZEQ9t0P:negative regulation of protein kinase activitysq~Z@Q9tP:protein modification processsq~Z=Q9tP:protein complex assemblysq~ZQ9tP:translational elongationsq~Z Q9t P:translationsq~ZQ9t0P:transcription initiation from RNA polymeras...sq~ZQ9t P:cell cyclesq~ZQ9t0P:regulation of transcription from RNA polyme...sq~Z&Q9t#P:regulation of signal transductionsq~Z \Q9t+P:positive regulation of cell proliferationsq~Z ]Q9t+P:negative regulation of cell proliferationsq~ZRQ9t'P:G1/S transition of mitotic cell cyclesq~ZvnQ9tP:melanocyte differentiationsq~ZQ9t/P:transcription from RNA polymerase II promotersq~ZQ9t,P:negative regulation of histone acetylationsq~ZQ9t0P:positive regulation of gene-specific transc...sq~ZQ9tP:histone exchangesq~ZQ9tP:regulation of transcriptionsq~Z`Q9t&P:regulation of neuron differentiationsq~Z-Q9t&P:epithelial to mesenchymal transitionsq~Z Q9tP:blastocyst developmentsq~ZQ9t+P:mitochondrion transport along microtubulesq~Z'Q9t#P:regulation of synaptic plasticitysq~ZIQ9t!P:actin filament bundle formationsq~ZBQ9t0P:negative regulation of transcriptional prei...sq~Z:Q9tP:protein transportsq~Z!Q9t0P:induction of apoptosis by intracellular sig...sq~Z@aQ9t&P:negative regulation of transcriptionsq~Z%Q9t$P:anatomical structure morphogenesissq~Z>@Q9tP:coenzyme A metabolic processsq~ZQ9tF:protein bindingsq~ZtQ9tF:transcription factor activitysq~ZQ9t F:RNA bindingsq~ZNQ9tF:structural molecule activitysq~ZQ9t0F:translation factor activity, nucleic acid b...sq~Z mQ9tF:DNA bending activitysq~ZQ9tF:transcription factor bindingsq~ZQQ9tF:microtubule bindingsq~ZgQ9tF:beta-tubulin bindingsq~Z Q9t%F:protein kinase C inhibitor activitysq~Z!Q9t0F:protein phosphatase type 2A regulator activitysq~Z#_Q9tF:electron carrier activitysq~Z@Q9t"F:transcription activator activitysq~ZQ9tF:histone bindingsq~Zw@Q9t"F:transcription regulator activitysq~Zv{Q9tF:estrogen receptor bindingsq~ZBQ9t$F:nucleoside-triphosphatase activitysq~Z@Q9t-F:specific transcriptional repressor activitysq~ZʧQ9tF:Hsp90 protein bindingsq~Z'Q9t-F:insulin-like growth factor receptor bindingsq~ZQ9tF:signal transducer activitysq~ZQ9tF:valine-tRNA ligase activitysq~ZQ9t(F:protein phosphatase inhibitor activitysq~ZQ9t!F:methionine-tRNA ligase activitysq~ZQ9tF:spermidine synthase activitysq~Z"Q9t0F:phosphoribosylformylglycinamidine synthase ...sq~ZQ9t F:ATP bindingsq~Z Q9t"F:glutathione transferase activitysq~ZQ9tF:enoyl-CoA hydratase activitysq~ZQ9tF:aldehyde reductase activitysq~ZOQ9tF:endopeptidase activitysq~Z_Q9tF:transporter activitysq~ZqQ9tF:single-stranded DNA bindingsq~ZQ9tF:protein kinase C bindingsq~ZQ9t!F:transcription cofactor activitysq~ZQ9t$F:transcription corepressor activitysq~ZQ9t$F:structural constituent of ribosomesq~Z&Q9tF:ATP citrate synthase activitysq~Z Q9t C:nucleussq~ZiQ9t C:cytoplasmsq~ZWQ9t!C:perinuclear region of cytoplasmsq~ZQ9t&C:proteasome complex (sensu Eukaryota)sq~ZQ9tC:intracellularsq~ZQ9t0C:eukaryotic translation initiation factor 3 ...sq~ZkQ9tC:mitochondrionsq~ZQ9t0C:proteasome regulatory particle (sensu Eukar...sq~ZQ9t0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZQ9t C:polysomesq~ZQ9tC:condensed nuclear chromosomesq~ZQ9tC:condensed chromosomesq~ZQ9tC:cytoskeletonsq~ZQ9t%C:protein phosphatase type 2A complexsq~ZQ9t C:cytosolsq~ZQ9tC:endoplasmic reticulumsq~ZQ9tC:extracellular spacesq~Z$Q9tC:citrate lyase complexsq~ZQ9tC:soluble fractionsq~Z= Q9tC:actin cytoskeletonsq~ZQ9t"C:DNA replication factor A complexsq~Z#Q9tC:transcription factor complexsq~Z.Q9tC:chromatin assembly complexsq~ZQ9t+C:proteasome core complex (sensu Eukaryota)sq~ZoQ9tC:mitochondrial inner membranesq~ZuQ9tC:clathrin coatppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Q9tF:protein bindingt5515sq~Q9tF:transcription factor activityt3700ppppppppxsq~uq~ sq~Q9t IPR001092t HLH_basicpppppppppxsq~uq~ sq~Q9tHLHtPF00010pppppppppxtP19532t TFE3_HUMANpt Homo sapienstDIPAsq~P?t(V#0O%tDelta-interacting protein Asq~uq~ sq~U0OtENSG00000175602pppppppppxsq~uq~ sq~m0OtCCDC85Bsq~m0OtDIPAppppppppxsq~uq~ @sq~Z 0Ot,P:regulation of transcription, DNA-dependentsq~ZD0Ot$P:protein amino acid phosphorylationsq~Zo0Ot/P:ubiquitin-dependent protein catabolic processsq~Z0OtP:signal transductionsq~Zz0Ot0P:negative regulation of transcription from R...sq~ZF0Ot&P:protein amino acid dephosphorylationsq~Z@0OtP:protein modification processsq~Z0Ot P:exocytosissq~Zs0Ot0P:positive regulation of I-kappaB kinase/NF-k...sq~Z0OtP:cell cycle arrestsq~Zu0OtP:cell differentiationsq~Z]0OtP:muscle developmentsq~Zk0Ot&P:multicellular organismal developmentsq~Z ]0Ot+P:negative regulation of cell proliferationsq~Z [0OtP:cell proliferationsq~Z0Ot0P:establishment and/or maintenance of chromat...sq~Z0Ot0P:regulation of transcription from RNA polyme...sq~Z0Ot)P:nuclear mRNA 3'-splice site recognitionsq~Z0Ot/P:transcription from RNA polymerase II promotersq~ZJ0Ot.P:regulation of progression through cell cyclesq~Z0Ot(P:nuclear mRNA splicing, via spliceosomesq~ZO0Ot0P:regulation of cyclin-dependent protein kina...sq~Z0OtP:cell adhesionsq~Z0Ot0P:transcription from RNA polymerase III promotersq~Z0Ot0P:epidermal growth factor receptor signaling ...sq~ZY0OtP:activation of JNK activitysq~Z.0Ot(P:regulation of translational initiationsq~Zs0OtP:spermatogenesissq~Z0Ot$P:central nervous system developmentsq~Z0OtP:chromosome segregationsq~Z0Ot0P:regulation of transcription from RNA polyme...sq~Zl0OtP:microtubule nucleationsq~Z=0OtP:protein complex assemblysq~Z0OtP:mRNA catabolic processsq~Z0OtP:RNA processingsq~Z0Ot0P:mitochondrial electron transport, NADH to u...sq~Z0OtP:water transportsq~Z0Ot P:apoptosissq~Z0OtP:nucleosome assemblysq~Z0OtP:caspase activationsq~Z 0Ot-P:cell structure disassembly during apoptosissq~Z0Ot"P:regulation of muscle contractionsq~Z0Ot+P:regulation of striated muscle contractionsq~Z0Ot P:meiosissq~Z0Ot P:excretionsq~Z0OtP:ectoderm developmentsq~Z0Ot%P:positive regulation of angiogenesissq~Z0Ot0P:positive regulation of endothelial cell pro...sq~Z0OtP:mesonephros developmentsq~Z"0OtP:vasculogenesissq~Z0OtP:regulation of cell growthsq~Z0OtP:skeletal developmentsq~ZD0Ot0P:negative regulation of transcription, DNA-d...sq~Z0Ot P:cytokinesissq~Zx0Ot0P:positive regulation of transcription from R...sq~Z0OtP:mitotic spindle elongationsq~Z0Ot$P:positive regulation of JNK cascadesq~Z|0Ot0P:alternative nuclear mRNA splicing, via spli...sq~Z0Ot0P:chromatin-mediated maintenance of transcrip...sq~Z0Ot0P:microtubule cytoskeleton organization and b...sq~Z0Ot0P:inactivation of MAPK activity during osmola...sq~ZF0Ot0P:negative regulation of myeloid cell differe...sq~Z50Ot$P:intermediate filament organizationsq~Z \0Ot+P:positive regulation of cell proliferationsq~Z 0OtP:RNA splicingsq~Z!`0OtP:epidermis developmentsq~Z!0Ot0P:induction of apoptosis by intracellular sig...sq~Z%0Ot$P:anatomical structure morphogenesissq~Z@a0Ot&P:negative regulation of transcriptionsq~Zuw0Ot0P:regulation of mitotic metaphase/anaphase tr...sq~Zv60OtP:apoptotic nuclear changessq~Zw90Ot%P:androgen receptor signaling pathwaysq~Z:0Ot"P:negative regulation of apoptosissq~Z0Ot0P:Golgi to plasma membrane CFTR protein trans...sq~Z0OtP:regulation of apoptosissq~Z0OtP:B cell activationsq~Zj0Ot0P:positive regulation of stress-activated MAP...sq~Zr0Ot0P:G1-specific transcription in mitotic cell c...sq~Z+0OtF:protein bindingsq~Z N 0OtF:zinc ion bindingsq~Z]0Ot F:DNA bindingsq~Zt0OtF:transcription factor activitysq~Z0Ot F:RNA bindingsq~ZP0Ot(F:structural constituent of cytoskeletonsq~Z0Ot F:ATP bindingsq~Z30Ot#F:protein homodimerization activitysq~Z\0OtF:nucleic acid bindingsq~ZB0Ot*F:protein serine/threonine kinase activitysq~Z0Ot0F:cyclin-dependent protein kinase inhibitor a...sq~Z0OtF:phospholipid bindingsq~Z0OtF:calcium ion bindingsq~ZA0OtF:ATPase activitysq~Z0OtF:tropomyosin bindingsq~Z0Ot0F:protein tyrosine/serine/threonine phosphata...sq~Z;0OtF:neurexin bindingsq~Z@0OtF:protein kinase activitysq~Z0OtF:signal transducer activitysq~Z0Ot$F:transcription corepressor activitysq~Zv0Ot0F:RNA polymerase II transcription factor acti...sq~Z0Ot$F:transcription coactivator activitysq~Zy0Ot0F:RNA splicing factor activity, transesterifi...sq~Zw0Ot!F:pre-mRNA 3'-splice site bindingsq~Z@0Ot-F:specific transcriptional repressor activitysq~Z0OtF:androgen receptor bindingsq~Z?0OtF:kinase activitysq~ZF0Ot$F:histone methyltransferase activitysq~Ze0Ot&F:cysteine-type endopeptidase activitysq~Z}0Ot"F:ubiquitin thiolesterase activitysq~Z 0OtF:CARD domain bindingsq~Z0Ot!F:glucocorticoid receptor bindingsq~Z0OtF:protein complex scaffoldsq~Z0OtF:mRNA bindingsq~Zv{0OtF:estrogen receptor bindingsq~Z0Ot(F:translation initiation factor activitysq~Z0OtF:actin bindingsq~Zw0OtF:protein binding, bridgingsq~Z;0Ot&F:DNA-directed RNA polymerase activitysq~Zj0OtF:double-stranded DNA bindingsq~Z0OtF:single-stranded RNA bindingsq~Z0OtF:magnesium ion bindingsq~Z![0OtF:proteasome inhibitor activitysq~Z!0Ot+F:procollagen-lysine 5-dioxygenase activitysq~Z20OtF:identical protein bindingsq~Zx0Ot0F:specific RNA polymerase II transcription fa...sq~Z0OtF:water transporter activitysq~ZB0Ot0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~Z0OtF:death receptor bindingsq~Z0Ot0F:translation factor activity, nucleic acid b...sq~Z0Ot!F:eukaryotic cell surface bindingsq~Z0Ot*F:NADH dehydrogenase (ubiquinone) activitysq~Z0Ot#F:protein kinase inhibitor activitysq~Z0Ot0F:second spliceosomal transesterification act...sq~Z0OtF:SH3/SH2 adaptor activitysq~Z0Ot C:nucleussq~Zi0Ot C:cytoplasmsq~Z10Ot C:spliceosomesq~Z0Ot&C:proteasome complex (sensu Eukaryota)sq~Z0Ot C:cytosolsq~Z0Ot C:nucleoplasmsq~Z0OtC:intracellularsq~Z0OtC:intermediate filamentsq~ZM0OtC:extrinsic to plasma membranesq~Zk0OtC:mitochondrionsq~Z@0OtC:nuclear specksq~Z'0OtC:keratin filamentsq~ZwD0Ot)C:small nuclear ribonucleoprotein complexsq~Z0Ot+C:proteasome core complex (sensu Eukaryota)sq~Z{0OtC:apical cortexsq~Z0OtC:microtubule organizing centersq~Zs0Ot+C:mitochondrial respiratory chain complex Isq~Z0Ot0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z0OtC:spindle polesq~Z0Ot C:polysomesq~Z0Ot0C:eukaryotic translation initiation factor 3 ...sq~Z0OtC:troponin complexsq~ZW0Ot!C:perinuclear region of cytoplasmsq~Z0OtC:spindle microtubulesq~Z0Ot C:centrosomesq~Z0OtC:protein complexsq~Zu0OtC:transport vesiclesq~ZB0Ot#C:transcriptional repressor complexsq~Z0OtC:ESC/E(Z) complexsq~Z@0Ot C:PML bodysq~Z=0OtC:microtubule cytoskeletonsq~Z R0OtC:gamma-tubulin ring complexsq~Z0OtC:integral to plasma membranesq~Z0OtC:extracellular regionsq~Z 0OtC:nuclear poresq~Z!0Ot.C:DNA-directed RNA polymerase II, core complexsq~Z0OtC:endoplasmic reticulumsq~Z@0OtC:chromatin remodeling complexpppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxppptQ15834t DIPA_HUMANsq~uq~ sq~0Ot-Hepatitis delta antigen-interacting protein Asq~0Ot)Coiled-coil domain-containing protein 85Bppppppppxt Homo sapienstIKBEsq~P? ћQ23%tNF-kappa-B inhibitor epsilonsq~uq~ sq~UtENSG00000146232pppppppppxsq~uq~ sq~mtNFKBIEsq~mtIKBEppppppppxsq~uq~ sq~ZJtP:response to unfolded proteinsq~ZtP:anti-apoptosissq~Z9tP:protein foldingsq~Z*tP:inflammatory responsesq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~ZtP:signal transductionsq~Zut0P:positive regulation of nitric oxide biosynt...sq~ZRt'P:G1/S transition of mitotic cell cyclesq~ZFt&P:protein amino acid dephosphorylationsq~Z+tP:immune responsesq~Z ]t+P:negative regulation of cell proliferationsq~Z@tP:protein ubiquitinationsq~ZtP:cell adhesionsq~ZtP:transcriptionsq~ZtP:cell motilitysq~ZtP:caspase activationsq~ZtP:induction of apoptosissq~Zt P:apoptosissq~Zt!P:intracellular protein transportsq~Zt,P:regulation of transcription, DNA-dependentsq~Zt/P:transcription from RNA polymerase II promotersq~ZtP:mRNA processingsq~ZtP:arginyl-tRNA aminoacylationsq~ZtP:mitochondrial transportsq~Z@tP:protein modification processsq~Z=tP:protein complex assemblysq~Z8tP:cellular defense responsesq~Z'1tP:response to organic substancesq~ZKt0P:cytokine and chemokine mediated signaling p...sq~Z%t$P:anatomical structure morphogenesissq~Z!t0P:induction of apoptosis by intracellular sig...sq~Z tP:RNA splicingsq~ZUt'P:cytoplasmic sequestering of NF-kappaBsq~ZTtP:I-kappaB phosphorylationsq~ZQt#P:I-kappaB kinase/NF-kappaB cascadesq~Zt0P:G-protein coupled receptor protein signalin...sq~Zt0P:cell surface receptor linked signal transdu...sq~ZtP:cell cycle arrestsq~Zrt0P:negative regulation of microtubule depolyme...sq~Zvt)P:ER-associated protein catabolic processsq~ZgtP:actin filament organizationsq~Z^t0P:mitochondrial membrane organization and bio...sq~Z'tP:response to UV-Bsq~ZtP:DNA recombinationsq~Zt$P:negative regulation of DNA bindingsq~Zt0P:regulation of phosphoprotein phosphatase ac...sq~ZitP:microtubule-based processsq~Zt)P:negative regulation of caspase activitysq~ZƤt#P:T cell receptor signaling pathwaysq~Z*tP:protein refoldingsq~ZtP:cell morphogenesissq~Zxt-P:retrograde protein transport, ER to cytosolsq~ZxtP:unfolded protein responsesq~Zt+P:natural killer cell mediated cytotoxicitysq~Zǔt.P:activation of NF-kappaB transcription factorsq~ZɗtP:defense response to virussq~Zt P:DNA repairsq~ZtP:double-strand break repairsq~Zut&P:positive regulation of transcriptionsq~ZtF:protein bindingsq~ZtF:signal transducer activitysq~ZttF:transcription factor activitysq~Zt F:ATP bindingsq~ZNJtF:unfolded protein bindingsq~Z2tF:identical protein bindingsq~Zt F:RNA bindingsq~Zrt/F:protein serine/threonine phosphatase activitysq~Zvt*F:nitric-oxide synthase regulator activitysq~Zt$F:transcription coactivator activitysq~ZstF:NF-kappaB bindingsq~ZxtF:TPR domain bindingsq~ZtF:calcium ion bindingsq~ZMtF:protein kinase bindingsq~Z{t"F:ubiquitin protein ligase bindingsq~Zwt0F:Rac guanyl-nucleotide exchange factor activitysq~ZwtF:protein binding, bridgingsq~ZMtF:protein phosphatase bindingsq~ZutF:chaperone regulator activitysq~ZtF:caspase inhibitor activitysq~Z}tF:protein N-terminus bindingsq~ZtF:ATPase activity, coupledsq~Z=tF:phosphate bindingsq~Z|t*F:N-terminal myristoylation domain bindingsq~Z tF:ribonucleoprotein bindingsq~Z0tF:MHC class I protein bindingsq~ZtF:Rac GTPase bindingsq~Z3t#F:protein homodimerization activitysq~ZAtF:ATPase activitysq~Zt$F:transcription corepressor activitysq~Zt0F:carbamoyl-phosphate synthase (glutamine-hyd...sq~Zut'F:protein tyrosine phosphatase activitysq~Zt%F:ATP-dependent DNA helicase activitysq~Zt#F:ubiquitin-protein ligase activitysq~ZNtF:structural molecule activitysq~Zyt0F:RNA polymerase II transcription factor acti...sq~Z@tF:protein kinase activitysq~ZtF:cytokine activitysq~ZQtF:microtubule bindingsq~Z tF:IkappaB kinase activitysq~Zt'F:nuclear localization sequence bindingsq~Zt F:GTP bindingsq~ZtF:cytoskeletal protein bindingsq~Zi t C:cytoplasmsq~Zt C:nucleussq~Zt C:cytosolsq~ZtC:soluble fractionsq~Z'tC:cell surfacesq~Zt C:microtubulesq~ZtC:cytoskeletonsq~ZtC:plasma membranesq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZWt!C:perinuclear region of cytoplasmsq~ZtC:cytoplasmic partsq~ZtC:ubiquitin ligase complexsq~ZtC:extracellular regionsq~ZtC:extracellular spacesq~ZtC:intracellularsq~Zut,C:integral to endoplasmic reticulum membranesq~Z@tC:nuclear specksq~Zt#C:ER-Golgi intermediate compartmentsq~Zt C:microsomesq~ZtC:endoplasmic reticulum lumensq~Zt(C:NuA4 histone acetyltransferase complexsq~ZtC:endoplasmic reticulumsq~Zpt0C:mitochondrial inner membrane presequence tr...sq~ZktC:mitochondrionsq~ZtC:Bcl3/NF-kappaB2 complexsq~Z#tC:transcription factor complexsq~ZtC:membrane fractionsq~ZutC:clathrin coatppppppppppppppppppppppppppppppxsq~uq~ sq~t0P:cytoplasmic sequestering of transcription f...t42994sq~tF:protein bindingt5515sq~t C:cytoplasmt5737pppppppxsq~uq~ sq~t IPR002110tANKpppppppppxsq~uq~ sq~tAnktPF00023pppppppppxtO00221t IKBE_HUMANsq~uq~ sq~t NF-kappa-BIEsq~tI-kappa-B-epsilonsq~tIkappaBepsilonsq~t IkB-epsilonsq~tIkB-Epppppxt Homo sapienstTIMP2sq~P?J@F*P%t'Metalloproteinase inhibitor 2 precursorsq~uq~ sq~UPtENSG00000035862pppppppppxsq~uq~ sq~mPtTIMP2pppppppppxsq~8uq~ Psq~ZlPt P:proteolysissq~ZPtP:signal transductionsq~ZPtP:cell-matrix adhesionsq~ZJPtP:response to unfolded proteinsq~ZPtP:fatty acid beta-oxidationsq~ZPtP:L-serine biosynthetic processsq~ZoPt/P:ubiquitin-dependent protein catabolic processsq~ZOPt P:protein amino acid methylationsq~Z9PtP:protein foldingsq~ZPtP:cell adhesionsq~ZJPt.P:regulation of progression through cell cyclesq~Z=Pt%P:integrin-mediated signaling pathwaysq~ZuPtP:protein repairsq~Z#Pt"P:purine base biosynthetic processsq~Z [PtP:cell proliferationsq~Z Pt P:translationsq~ZPtP:embryo implantationsq~ZkPt&P:multicellular organismal developmentsq~Z=PtP:protein complex assemblysq~ZePtP:neurotransmitter secretionsq~ZPtF:protein bindingsq~Z2PtF:identical protein bindingsq~Z NPtF:zinc ion bindingsq~ZPt F:RNA bindingsq~ZPtF:gelatinase A activitysq~ZTPtF:GTPase activitysq~ZoPt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~ZPt0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~ZPtF:enoyl-CoA hydratase activitysq~Z PtF:heparin bindingsq~ZQPtF:aminopeptidase activitysq~ZOPtF:endopeptidase activitysq~ZMPtF:beta-catenin bindingsq~ZPtF:receptor activitysq~ZPt%F:GDP-dissociation inhibitor activitysq~Z!XPtF:Ran GTPase bindingsq~Z!#PtF:transaminase activitysq~ZPt!F:neutrophil collagenase activitysq~Z~PtF:metalloendopeptidase activitysq~ZPt$F:structural constituent of ribosomesq~ZPt F:ATP bindingsq~ZxPtF:steroid bindingsq~ZiPt C:cytoplasmsq~ZPt&C:proteasome complex (sensu Eukaryota)sq~Z qPtC:integrin complexsq~ZPtC:extracellular spacesq~ZPt C:nucleussq~ZPtC:integral to plasma membranesq~ZUPtC:synaptic vesiclesq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z?PtC:catenin complexsq~Z'PtC:cell surfacesq~ZPt C:cytosolsq~ZkPtC:mitochondrionsq~ZPtC:endoplasmic reticulumsq~ZPt+C:proteasome core complex (sensu Eukaryota)ppppppppppppppppppppppppxsq~uq~ sq~Pt)F:metalloendopeptidase inhibitor activityt8191sq~PtF:protein bindingt5515ppppppppxsq~uq~ sq~Pt IPR001134tNetrin_Csq~Pt IPR001820t Prot_inh_TIMPsq~Pt IPR015613tTIMP2pppppppxsq~uq~ sq~PtTIMPtPF00965pppppppppxtP16035t TIMP2_HUMANsq~uq~ sq~PtTIMP-2sq~Pt(Tissue inhibitor of metalloproteinases 2sq~PtCSC-21Kpppppppxt Homo sapienstPRIOsq~P?E &'%tMajor prion protein precursorsq~uq~ sq~UtENSG00000171867pppppppppxsq~uq~ sq~mtPRNPsq~mtPRIPsq~mtPRPpppppppxsq~uq~ sq~ZtP:cell adhesionsq~ZtP:signal transductionsq~ZtP:nervous system developmentsq~ZtP:induction of apoptosissq~Zt$P:central nervous system developmentsq~ZtP:cholesterol homeostasissq~Zt,P:regulation of transcription, DNA-dependentsq~Z+tP:immune responsesq~Z&tP:response to stresssq~Z ^t$P:insulin receptor signaling pathwaysq~ZJtP:response to unfolded proteinsq~ZtP:anti-apoptosissq~ZtP:receptor-mediated endocytosissq~Zt!P:cellular copper ion homeostasissq~ZtP:lipid transportsq~ZtP:lipid metabolic processsq~ZDt$P:protein amino acid phosphorylationsq~Z9tP:protein foldingsq~ZtP:mRNA processingsq~Zgt$P:synaptic transmission, cholinergicsq~Zbt*P:cytoskeleton organization and biogenesissq~ZtP:cell cycle arrestsq~ZftP:neuron recognitionsq~ZOt P:circulationsq~ZtP:learning and/or memorysq~ZtP:blood coagulationsq~ZtP:axonogenesissq~ZvtP:spermatid developmentsq~Z ]t+P:negative regulation of cell proliferationsq~ZctP:cell-cell signalingsq~Zt0P:negative regulation of blood vessel endothe...sq~Zt0P:G-protein coupled receptor protein signalin...sq~Zt0P:epidermal growth factor receptor signaling ...sq~ZtP:neuron adhesionsq~ZtP:heterophilic cell adhesionsq~ZtP:homophilic cell adhesionsq~ZGt0P:peptidyl-proline hydroxylation to 4-hydroxy...sq~ZtP:regulation of transcriptionsq~ZtP:regulation of apoptosissq~Zt)P:negative regulation of caspase activitysq~ZtP:lipoprotein metabolic processsq~Zut*P:protein import into mitochondrial matrixsq~Zat!P:Ras protein signal transductionsq~Zv]tP:cholesterol transportsq~Z,tP:complement activationsq~Zvdt$P:negative regulation of cell growthsq~Z>tP:protein tetramerizationsq~Zw4tP:regulation of axon extensionsq~ZtP:neuromuscular processsq~Z@t%P:negative regulation of angiogenesissq~Zt0P:negative regulation of S phase of mitotic c...sq~Z~tP:entry of virus into host cellsq~Z;tP:intracellular transportsq~ZHt0P:negative regulation of thymidylate synthase...sq~Z&tP:organ morphogenesissq~Z(t,P:regulation of neuronal synaptic plasticitysq~ZtP:RNA transportsq~Z.t%P:response to reactive oxygen speciessq~Z tF:protein bindingsq~ZJtF:protein kinase CK2 activitysq~Z2tF:identical protein bindingsq~Zt F:ATP bindingsq~Z}tF:protein N-terminus bindingsq~ZtF:beta-amyloid bindingsq~ZNJtF:unfolded protein bindingsq~Z3t#F:protein homodimerization activitysq~ZwtF:protein binding, bridgingsq~Z!t'F:protein kinase CK2 regulator activitysq~ZtF:caspase inhibitor activitysq~Z't'F:single-stranded telomeric DNA bindingsq~Z /tF:dipeptidyl-peptidase activitysq~Z@t"F:transcription repressor activitysq~Z?QtF:antioxidant activitysq~Z<}tF:cholesterol bindingsq~Z:tF:coreceptor activitysq~Z -tF:metallopeptidase activitysq~Z tF:heparin bindingsq~ZNtF:structural molecule activitysq~Z:tF:integrin bindingsq~Z"t*F:epidermal growth factor receptor bindingsq~ZytF:opioid receptor activitysq~Z0t,F:procollagen-proline 4-dioxygenase activitysq~Zt)F:fructose-bisphosphate aldolase activitysq~ZtF:plasmin activitysq~ZTtF:GTPase activitysq~Zt&F:protein disulfide isomerase activitysq~Zt F:RNA bindingsq~ZttF:transcription factor activitysq~Z]t F:DNA bindingsq~ZtF:calcium ion bindingsq~ZtF:phospholipid bindingsq~ZtF:transcription factor bindingsq~Z(t$F:insulin receptor substrate bindingsq~Zt.F:serine-type endopeptidase inhibitor activitysq~ZǏtF:chaperone bindingsq~ZtF:tau protein bindingsq~Z=t#F:apolipoprotein E receptor bindingsq~ZtF:SH3/SH2 adaptor activitysq~Zt C:nucleussq~Z>tC:integral to membranesq~ZtC:plasma membranesq~ZtC:integral to plasma membranesq~ZtC:extracellular regionsq~Z'tC:cell surfacesq~Zt#C:ER-Golgi intermediate compartmentsq~ZtC:endoplasmic reticulumsq~ZtC:extracellular spacesq~ZktC:mitochondrionsq~Zit C:cytoplasmsq~ZtC:Golgi membranesq~ZWt!C:perinuclear region of cytoplasmsq~Z1t C:spliceosomesq~ZtC:membrane fractionsq~ZtC:basement membranesq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZtC:endoplasmic reticulum lumensq~ZwBt0C:heterogeneous nuclear ribonucleoprotein com...sq~Zut,C:integral to endoplasmic reticulum membranesq~ZuKtC:lamellipodiumsq~Z@tC:caveolar membranesq~ZDtC:protein kinase CK2 complexsq~ZAt C:lipid raftsq~Zt C:synapsesq~ZtC:adherens junctionsq~Zt C:cytosolsq~ZtC:Golgi apparatussq~Zvt C:growth conepppppppppppppppppppppppppppppppppxsq~ uq~ sq~t!P:cellular copper ion homeostasist6878sq~tP:metabolic processt8152sq~tP:response to oxidative stresst6979sq~tF:copper ion bindingt5507sq~tF:microtubule bindingt8017sq~tC:endoplasmic reticulumt5783sq~tC:extrinsic to membranet19898sq~tC:Golgi apparatust5794sq~t C:lipid raftt45121pxsq~uq~ sq~t IPR000817tPrionpppppppppxsq~uq~ sq~tPriontPF00377sq~t Prion_octapeptPF03991ppppppppxtP04156t PRIO_HUMANsq~uq~ sq~tPrPsq~tPrP27-30sq~t PrP33-35Csq~tASCRsq~t CD230 antigenpppppxt Homo sapienstTBG1sq~P? >%tTubulin gamma-1 chainsq~uq~ sq~U>tENSG00000131462pppppppppxsq~uq~ sq~m>tTUBG1sq~m>tTUBGppppppppxsq~{uq~ sq~Zl>tP:microtubule nucleationsq~Z%>t$P:anatomical structure morphogenesissq~Z>t+P:natural killer cell mediated cytotoxicitysq~Z:>t"P:negative regulation of apoptosissq~Z>tP:cell motilitysq~Z j>t!P:intracellular mRNA localizationsq~Z ^>t$P:insulin receptor signaling pathwaysq~Z!>t0P:DNA damage response, signal transduction re...sq~ZF>t!P:peptidyl-serine phosphorylationsq~Z>tP:visual perceptionsq~Z>tP:neuroblast proliferationsq~Z>tP:nervous system developmentsq~Z [>tP:cell proliferationsq~Zs>tP:spermatogenesissq~Z>tP:cell cycle arrestsq~Z>tP:chromosome segregationsq~Z>t P:mitosissq~Z>t'P:cytokinesis, initiation of separationsq~Z>tP:cell adhesionsq~Z>tP:signal complex assemblysq~ZJ>t!P:intracellular signaling cascadesq~Za>t!P:Ras protein signal transductionsq~Zi>tP:microtubule-based processsq~Z&>>tP:embryonic developmentsq~Z>t#P:positive regulation of DNA repairsq~ZE>t0P:positive regulation of transcription, DNA-d...sq~Z>t.P:negative regulation of centriole replicationsq~Z>tP:microtubule polymerizationsq~Z>t0P:positive regulation of protein export from ...sq~Z>t"P:phosphoinositide phosphorylationsq~Z>t0P:insulin-like growth factor receptor signali...sq~Zb>tP:centrosome duplicationsq~Z>tP:sarcomere organizationsq~Zk>tP:response to estrogen stimulussq~Z<>t.P:positive regulation of programmed cell deathsq~Z@a>t&P:negative regulation of transcriptionsq~ZN>t'P:negative regulation of anti-apoptosissq~Zw9>t%P:androgen receptor signaling pathwaysq~Zz>t/P:positive regulation of protein ubiquitinationsq~Z>t"P:regulation of cell proliferationsq~Z>tP:cilium biogenesissq~Z>t0P:Wnt receptor signaling pathway through beta...sq~Z>t0P:Golgi to plasma membrane CFTR protein trans...sq~Ze>tP:cell divisionsq~ZG>tP:ER overload responsesq~Z>t0P:negative regulation of fatty acid biosynthe...sq~Z>t)P:cytokinesis, contractile ring formationsq~Z>t P:cytokinesissq~Z*>tP:microtubule bundle formationsq~Z>t0P:microtubule cytoskeleton organization and b...sq~ZJ>t.P:regulation of progression through cell cyclesq~Z>t0P:double-strand break repair via homologous r...sq~ZY>tP:glycogen metabolic processsq~Z>tP:postreplication repairsq~Z>t0P:regulation of transcription from RNA polyme...sq~Z>t0P:regulation of transcription from RNA polyme...sq~Z>tP:RNA processingsq~Z=>tP:protein complex assemblysq~ZB>t0P:DNA damage response, signal transduction by...sq~Z@>tP:protein modification processsq~ZD>t$P:protein amino acid phosphorylationsq~Z>t!P:intracellular protein transportsq~Z >tF:protein bindingsq~ZP>t(F:structural constituent of cytoskeletonsq~Z>tF:gamma-tubulin bindingsq~Z N>tF:zinc ion bindingsq~Z0>tF:MHC class I protein bindingsq~Z>t F:GTP bindingsq~ZQ>tF:microtubule bindingsq~ZB>t*F:protein serine/threonine kinase activitysq~Z=>tF:tubulin bindingsq~Z>tF:alpha-tubulin bindingsq~Zu>tF:ErbB-3 class receptor bindingsq~ZX>t%F:glycogen synthase kinase 3 activitysq~Z>tF:GTPase activator activitysq~Zz>tF:ubiquitin bindingsq~Z'>tF:insulin bindingsq~Z(>t$F:insulin receptor substrate bindingsq~ZNJ>tF:unfolded protein bindingsq~Z>tF:androgen receptor bindingsq~Zđ>tF:tau-protein kinase activitysq~Zg>tF:beta-tubulin bindingsq~Z0>t,F:procollagen-proline 4-dioxygenase activitysq~Zs>tF:NF-kappaB bindingsq~Z>t F:p53 bindingsq~Z]>t F:DNA bindingsq~Z'>t-F:insulin-like growth factor receptor bindingsq~Z>t$F:transcription coactivator activitysq~Z2>tF:identical protein bindingsq~ZM>tF:enzyme bindingsq~ZC>tF:vinculin bindingsq~ZM>tF:protein phosphatase bindingsq~Z>tF:phosphatidylinositol bindingsq~Z&>tF:insulin receptor bindingsq~Z>t F:ATP bindingsq~Z>tF:transcription factor bindingsq~Z>t.F:phosphoinositide 3-kinase regulator activitysq~Z;>tF:porin activitysq~Z s>t"F:structural constituent of musclesq~Z>t C:centrosomesq~Z>t C:nucleussq~Z>tC:cytoskeletonsq~Z R>tC:gamma-tubulin ring complexsq~Z>t C:centriolesq~Z>t&C:proteasome complex (sensu Eukaryota)sq~Z>tC:polar microtubulesq~Z>t-C:phosphoinositide 3-kinase complex, class IAsq~Z S>tC:gamma-tubulin small complexsq~Z>t C:microtubulesq~Z>t C:microtubule associated complexsq~Z>tC:Golgi apparatussq~Z>tC:endoplasmic reticulumsq~Z{>tC:spindle pole centrosomesq~Zz>tC:BRCA1-BARD1 complexsq~Z>tC:neuron projectionsq~Zx>t"C:beta-catenin destruction complexsq~Z>t C:costameresq~ZM>tC:outer membranesq~Z'>tC:keratin filamentsq~Z>>tC:integral to membranesq~Z=>tC:microtubule cytoskeletonsq~Zi>t C:cytoplasmsq~Z>tC:intermediate filamentpppppppppppppppppppppppppppppppppppppxsq~uq~ sq~>t-P:meiotic spindle organization and biogenesist212sq~>tF:protein bindingt5515sq~>t(F:structural constituent of cytoskeletont5200sq~>t C:centrosomet5813sq~>tC:condensed nuclear chromosomet794sq~>tC:gamma-tubulin complext930sq~>tC:polar microtubulet5827sq~>tC:spindle pole bodyt5816ppxsq~uq~ sq~>t IPR002454t Gamma_tubulinsq~>t IPR008280t Tub_FtsZ_Csq~>t IPR000217tTubulinsq~>t IPR003008t Tubulin_FtsZppppppxsq~uq~ sq~>tTubulintPF00091sq~>t Tubulin_CtPF03953ppppppppxtP23258t TBG1_HUMANsq~uq~ sq~>tGamma-1-tubulinsq~>t!Gamma-tubulin complex component 1sq~>tGCP-1pppppppxt Homo sapienstEXOS6sq~P?%X%t Exosome complex exonuclease MTR3sq~uq~ sq~UtENSG00000157344pppppppppxsq~uq~ sq~mtEXOSC6sq~mtMTR3ppppppppxsq~0uq~ Psq~ZtP:mRNA processingsq~Zt0P:mRNA catabolic process, nonsense-mediated d...sq~Zt(P:nuclear mRNA splicing, via spliceosomesq~Z.t(P:regulation of translational initiationsq~ZtP:mRNA export from nucleussq~ZtP:mRNA catabolic processsq~ZtP:RNA catabolic processsq~Zt0P:oxygen and reactive oxygen species metaboli...sq~ZtP:rRNA processingsq~ZtP:protein import into nucleussq~Zt!P:intracellular protein transportsq~Z+tP:immune responsesq~Z tP:RNA splicingsq~Z!t0P:induction of apoptosis by extracellular sig...sq~ZBt0P:negative regulation of protein biosynthetic...sq~Zv6tP:apoptotic nuclear changessq~ZOtP:regulation of GTPase activitysq~ZDt0P:negative regulation of transcription, DNA-d...sq~Zvdt$P:negative regulation of cell growthsq~ZtF:protein bindingsq~Zt F:RNA bindingsq~ZBtF:U6 snRNA bindingsq~Zt0F:translation factor activity, nucleic acid b...sq~Zt*F:NADH dehydrogenase (ubiquinone) activitysq~ZtF:single-stranded RNA bindingsq~Z tF:3'-5' exonuclease activitysq~Zt%F:protein heterodimerization activitysq~Z]t F:DNA bindingsq~Zt F:3'-5'-exoribonuclease activitysq~Zyt0F:RNA splicing factor activity, transesterifi...sq~Z2tF:identical protein bindingsq~ZtF:mRNA bindingsq~Zt,F:ligand-dependent nuclear receptor activitysq~ZtF:GTPase activator activitysq~Zt F:ATP bindingsq~Zt C:nucleussq~ZtC:exosome (RNase complex)sq~Zt C:centrosomesq~Zt C:cytosolsq~ZtC:paraspecklessq~Zt0C:eukaryotic translation initiation factor 3 ...sq~ZtC:plasma membranesq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zbt C:nucleolussq~Zt C:nucleoplasmsq~ZtC:soluble fractionsq~Zst+C:mitochondrial respiratory chain complex Isq~Zit C:cytoplasmppppppppppppppppppppppppppppppppxpsq~uq~ sq~t IPR001247tExoRNase_PH_dom1pppppppppxsq~uq~ sq~tRNase_PHtPF01138pppppppppxtQ5RKV6t EXOS6_HUMANsq~uq~ sq~t"mRNA transport regulator 3 homologsq~thMtr3sq~tExosome component 6sq~tp11ppppppxt Homo sapienstATN1sq~P?wrDs%t Atrophin-1sq~uq~ sq~UDtENSG00000111676pppppppppxsq~uq~ sq~mDtATN1sq~mDtD12S755Esq~mDtDRPLApppppppxsq~uq~ @sq~ZlDt P:proteolysissq~Z@aDt&P:negative regulation of transcriptionsq~ZsDt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZDtP:cell adhesionsq~ZDtP:signal transductionsq~ZDt,P:regulation of transcription, DNA-dependentsq~Z~DtP:entry of virus into host cellsq~Z&DtP:organ morphogenesissq~ZDt"P:regulation of cell proliferationsq~ZDt P:apoptosissq~ZoDt/P:ubiquitin-dependent protein catabolic processsq~ZuDt0P:negative regulation of Wnt receptor signali...sq~ZdDtP:synaptic transmissionsq~Z@DtP:histone acetylationsq~ZDt P:glycolysissq~Z!DtP:apoptotic programsq~ZDt$P:central nervous system developmentsq~ZDtP:axon guidancesq~ZDt P:cell cyclesq~ZDt0P:cell surface receptor linked signal transdu...sq~ZuDt&P:positive regulation of transcriptionsq~ZDt0P:regulation of epidermal growth factor recep...sq~ZDtP:DNA methylationsq~ZDtP:signal complex assemblysq~ZDtP:DNA recombinationsq~ZDtP:nucleosome assemblysq~ZDt/P:transcription from RNA polymerase II promotersq~ZDt P:DNA repairsq~ZtDtP:DNA replicationsq~ZYDtP:activation of JNK activitysq~ZDtP:nervous system developmentsq~ZsDtP:spermatogenesissq~Z3DtP:Notch signaling pathwaysq~ZcDtP:cell-cell signalingsq~ZrDt(P:fructose 6-phosphate metabolic processsq~ZDtP:cell-matrix adhesionsq~Z-Dt0P:acetylcholine receptor signaling, muscarini...sq~ZDtP:regulation of glycolysissq~ZDt0P:generation of precursor metabolites and energysq~ZDtP:RNA processingsq~Z*DtP:inflammatory responsesq~ZDtP:cell motilitysq~Z8DtP:cellular defense responsesq~ZDtP:induction of apoptosissq~Z`Dt+P:small GTPase mediated signal transductionsq~ZDtP:receptor-mediated endocytosissq~ZDt P:transportsq~ZDtP:lipid metabolic processsq~ZDt+P:NLS-bearing substrate import into nucleussq~ZpDtP:ubiquitin cyclesq~ZlDtP:microtubule nucleationsq~ZVDt"P:protein amino acid glycosylationsq~ZDDt$P:protein amino acid phosphorylationsq~ZADtP:signal peptide processingsq~Z@DtP:protein modification processsq~Z=DtP:protein complex assemblysq~ZDt%P:spindle organization and biogenesissq~Z+DtP:immune responsesq~ZDtP:axonogenesissq~ZzDt0P:negative regulation of transcription from R...sq~ZDtP:thymic T cell selectionsq~ZDt$P:negative regulation of DNA bindingsq~ZiDtP:receptor clusteringsq~Z:Dt"P:negative regulation of apoptosissq~ZDt0P:cytoplasmic sequestering of transcription f...sq~ZvDt-P:positive regulation of T cell proliferationsq~ZYDt0P:chromosome organization and biogenesis (sen...sq~Zw8Dt%P:estrogen receptor signaling pathwaysq~ZvDt)P:ER-associated protein catabolic processsq~ZvDt'P:positive regulation of cell migrationsq~ZjDt-P:clustering of voltage-gated sodium channelssq~ZpDt0P:regulation of small GTPase mediated signal ...sq~ZxDt%P:synapse organization and biogenesissq~ZDtP:focal adhesion formationsq~ZDt(P:telomere maintenance via recombinationsq~ZDt%P:phosphoinositide-mediated signalingsq~ZDtP:skeletal developmentsq~ZDtP:regulation of cell growthsq~ZDtP:cell fate determinationsq~ZDtP:microtubule polymerizationsq~Zv~DtP:regulation of cell migrationsq~Zv8Dt(P:nuclear fragmentation during apoptosissq~ZuDtP:platelet activationsq~Z&>DtP:embryonic developmentsq~Z!Dt.P:release of cytoplasmic sequestered NF-kappaBsq~Z!`DtP:epidermis developmentsq~Z DtP:axon ensheathmentsq~Z Dt P:endosome to lysosome transportsq~Z ^Dt$P:insulin receptor signaling pathwaysq~Z ]Dt+P:negative regulation of cell proliferationsq~ZPDt!P:regulation of heart contractionsq~ZDtP:visual perceptionsq~ZDt!P:imaginal disc pattern formationsq~Z&Dt(P:auditory receptor cell fate commitmentsq~Z&Dt#P:dorsal/ventral axis specificationsq~ZuDtP:protein catabolic processsq~ZxvDt0P:positive regulation of actin filament polym...sq~ZDtP:brain developmentsq~ZuDtP:myeloid cell differentiationsq~ZBDtP:phospholipid scramblingsq~Z@DtP:protein ubiquitinationsq~Z>DtP:RNA metabolic processsq~ZeDtP:cell divisionsq~Z%DtF:protein bindingsq~ZDtF:calcium ion bindingsq~ZDt F:RNA bindingsq~ZDtF:signal transducer activitysq~ZNDtF:structural molecule activitysq~ZDt#F:ubiquitin-protein ligase activitysq~Z2DtF:identical protein bindingsq~ZDtF:transcription factor bindingsq~Z\DtF:nucleic acid bindingsq~ZDt F:ATP bindingsq~ZQDt-F:extracellular matrix structural constituentsq~ZPDt(F:structural constituent of cytoskeletonsq~Z NDtF:zinc ion bindingsq~ZwDtF:caspase activitysq~ZVDtF:protein C-terminus bindingsq~Z2Dt$F:histone acetyltransferase activitysq~ZDtF:nucleotide bindingsq~ZDt$F:transcription corepressor activitysq~ZDt0F:transforming growth factor beta receptor ac...sq~Z"DtF:helicase activitysq~Z Dt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZtDtF:transcription factor activitysq~ZDtF:cytoskeletal adaptor activitysq~ZDtF:growth factor activitysq~Z}Dt(F:voltage-gated calcium channel activitysq~ZuDt.F:receptor signaling complex scaffold activitysq~Z^DtF:DNA helicase activitysq~ZMDtF:phosphatase bindingsq~ZMDtF:kinase bindingsq~ZBDt"F:phospholipid scramblase activitysq~ZDt F:GTP bindingsq~Z Dt F:6-phosphofructokinase activitysq~Z=DtF:tubulin bindingsq~Z:DtF:integrin bindingsq~ZvDt"F:thyroid hormone receptor bindingsq~Z6Dt*F:H3/H4 histone acetyltransferase activitysq~ZDt$F:serine-type endopeptidase activitysq~ZWDt F:NAD bindingsq~ZDtF:laminin bindingsq~ZTDtF:GTPase activitysq~ZDtF:Notch bindingsq~ZDt F:interleukin-1 receptor bindingsq~ZADt!F:acid-amino acid ligase activitysq~ZDtF:phosphatidylinositol bindingsq~ZBDt*F:protein serine/threonine kinase activitysq~Z!DtF:caspase activator activitysq~Z KDtF:poly-glutamine tract bindingsq~Z *Dt"F:cysteine-type peptidase activitysq~Z@Dt"F:transcription activator activitysq~Z@Dt"F:transcription repressor activitysq~Zi Dt C:cytoplasmsq~Z Dt C:nucleussq~ZDt$C:proteinaceous extracellular matrixsq~ZDtC:extracellular spacesq~ZDtC:soluble fractionsq~ZDtC:plasma membranesq~ZDtC:intermediate filamentsq~ZDt&C:proteasome complex (sensu Eukaryota)sq~ZDtC:intracellularsq~ZDtC:ubiquitin ligase complexsq~ZDtC:basal laminasq~ZDt C:nucleosomesq~ZDt C:cytosolsq~Z%DtC:focal adhesionsq~ZDtC:cytoskeletonsq~ZDtC:Golgi apparatussq~ZDtC:intercellular junctionsq~ZDtC:integral to plasma membranesq~ZDt'C:voltage-gated calcium channel complexsq~ZDtC:extracellular regionsq~ZDt C:endoplasmic reticulum membranesq~Z?DtC:nuclear matrixsq~ZDtC:basement membranesq~Z=DtC:microtubule cytoskeletonsq~ZADtC:telomerase holoenzyme complexsq~ZXDtC:nuclear heterochromatinsq~ZkDtC:mitochondrionsq~Z|DtC:mitochondrial membranesq~ZDt C:lysosomesq~ZDt C:endosomesq~ZDtC:endoplasmic reticulumsq~Z SDtC:gamma-tubulin small complexsq~Z9DtC:6-phosphofructokinase complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Dt$P:central nervous system developmentt7417sq~DtF:protein bindingt5515sq~Dt C:cytoplasmt5737sq~Dt C:nucleust5634ppppppxsq~uq~ sq~Dt IPR002951tAtrophinpppppppppxsq~uq~ sq~Dt Atrophin-1tPF03154pppppppppxtP54259t ATN1_HUMANsq~uq~ sq~Dt,Dentatorubral-pallidoluysian atrophy proteinpppppppppxt Homo sapienstGRP78sq~P?VgAXX%t*78 kDa glucose-regulated protein precursorsq~uq~ sq~UtENSG00000044574pppppppppxsq~uq~ sq~mtHSPA5sq~mtGRP78ppppppppxsq~uq~ @sq~Z tP:signal transductionsq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~ZDt$P:protein amino acid phosphorylationsq~ZƤt#P:T cell receptor signaling pathwaysq~ZRt)P:activation of NF-kappaB-inducing kinasesq~Zƶt*P:positive regulation of T cell activationsq~Z*tP:inflammatory responsesq~Z<tP:protein homooligomerizationsq~Z t0P:positive regulation of T cell cytokine prod...sq~ZtP:anti-apoptosissq~ZctP:cell-cell signalingsq~Z [tP:cell proliferationsq~Z!`tP:epidermis developmentsq~ZKt0P:cytokine and chemokine mediated signaling p...sq~ZdtP:synaptic transmissionsq~ZtP:cell cycle arrestsq~ZGtP:ER overload responsesq~ZtP:lipid metabolic processsq~Z9tP:protein foldingsq~Zt P:transportsq~Zt/P:transcription from RNA polymerase II promotersq~Zt,P:regulation of transcription, DNA-dependentsq~Zt!P:intracellular protein transportsq~ZtP:induction of apoptosissq~Z+tP:immune responsesq~Z8tP:cellular defense responsesq~Z \t+P:positive regulation of cell proliferationsq~Zǔt.P:activation of NF-kappaB transcription factorsq~Zt(P:protein amino acid autophosphorylationsq~Zt P:apoptosissq~ZtP:cell adhesionsq~Zt$P:negative regulation of DNA bindingsq~Zut&P:positive regulation of transcriptionsq~Zot/P:ubiquitin-dependent protein catabolic processsq~ZktP:microtubule depolymerizationsq~ZgtP:actin filament organizationsq~Z%t$P:negative regulation of proteolysissq~ZtP:signal complex assemblysq~Zt0P:epidermal growth factor receptor signaling ...sq~Z t0P:transforming growth factor beta receptor si...sq~Zt0P:G-protein coupled receptor protein signalin...sq~Zt0P:G-protein signaling, coupled to cyclic nucl...sq~Z=t%P:integrin-mediated signaling pathwaysq~ZJt!P:intracellular signaling cascadesq~ZQt#P:I-kappaB kinase/NF-kappaB cascadesq~Zt'P:positive regulation of anti-apoptosissq~Zbt*P:cytoskeleton organization and biogenesissq~ZKt0P:unfolded protein response, activation of si...sq~Zxt0P:positive regulation of transcription from R...sq~ZetP:cell divisionsq~Z>tP:protein tetramerizationsq~Z%t!P:prostaglandin metabolic processsq~ZǙt*P:negative regulation of helicase activitysq~Zƥt#P:B cell receptor signaling pathwaysq~ZtP:lipid transportsq~Z)t.P:positive regulation of inflammatory responsesq~Zt!P:cellular copper ion homeostasissq~Zt!P:regulation of protein secretionsq~Zt P:endocytosissq~Z6t0P:regulation of mitochondrial membrane permea...sq~Zt0P:nerve growth factor receptor signaling pathwaysq~Zt0P:platelet-derived growth factor receptor sig...sq~Zt0P:negative regulation of glucosylceramide bio...sq~ZCtP:response to oxidative stresssq~ZUt'P:cytoplasmic sequestering of NF-kappaBsq~Zt0P:positive regulation of cholesterol biosynth...sq~Z'tP:response to UV-Bsq~Z>tP:RNA metabolic processsq~Z@ftP:peptide hormone processingsq~Zt0P:Golgi to plasma membrane CFTR protein trans...sq~ZutP:platelet activationsq~Zt0P:cytoplasmic sequestering of transcription f...sq~Zv[tP:cholesterol absorptionsq~Zv]tP:cholesterol transportsq~Zvdt$P:negative regulation of cell growthsq~Zvt'P:positive regulation of cell migrationsq~ZxtP:unfolded protein responsesq~Zy*t P:endocrine pancreas developmentsq~Z{etP:cell-substrate adhesionsq~ZtP:regulation of apoptosissq~Z}9t0P:negative regulation of translation initiati...sq~Zt)P:cellular response to glucose starvationsq~ZtP:lipoprotein metabolic processsq~Z'1tP:response to organic substancesq~Z%t$P:anatomical structure morphogenesissq~ZɗtP:defense response to virussq~Zkt&P:multicellular organismal developmentsq~ZtP:axon guidancesq~Zt P:cell agingsq~Zt P:digestionsq~ZtP:blood coagulationsq~ZOt P:circulationsq~ZtP:protein localizationsq~ZtP:metabolic processsq~ZtP:actin nucleationsq~Zt-P:mitotic spindle organization and biogenesissq~Z ^t$P:insulin receptor signaling pathwaysq~Z:t"P:negative regulation of apoptosissq~Z!t0P:induction of apoptosis by extracellular sig...sq~Z!tP:apoptotic programsq~Z!t%P:caspase activation via cytochrome csq~Z$ZtP:protein secretionsq~Zt0P:DNA damage response, signal transduction by...sq~Zlt P:proteolysissq~Z]t+P:protein amino acid O-linked glycosylationsq~ZtP:angiogenesissq~ZtP:protein polyubiquitinationsq~ZtP:regulation of cell growthsq~ZtP:response to hypoxiasq~ZtP:activation of MAPK activitysq~ZtP:activation of MAPKKK activitysq~ZtP:MAPKKK cascadesq~ZJt.P:regulation of progression through cell cyclesq~Zrt(P:fructose 6-phosphate metabolic processsq~ZtP:ossificationsq~Z@tP:protein modification processsq~ZtP:regulation of glycolysissq~Z=tP:protein complex assemblysq~ZtP:base-excision repairsq~ZtP:nucleotide-excision repairsq~ZtP:transcriptionsq~ZtP:translational elongationsq~Zt0P:regulation of transcription from RNA polyme...sq~ZtF:protein bindingsq~Z tF:signal transducer activitysq~ZBt*F:protein serine/threonine kinase activitysq~Zt F:ATP bindingsq~ZttF:transcription factor activitysq~Z2tF:identical protein bindingsq~Zt$F:transcription coactivator activitysq~Z}tF:protein N-terminus bindingsq~Z@tF:protein kinase activitysq~Zet#F:MAP kinase kinase kinase activitysq~ZPt(F:structural constituent of cytoskeletonsq~ZNJtF:unfolded protein bindingsq~ZtF:calcium ion bindingsq~ZtF:lipid transporter activitysq~ZstF:NF-kappaB bindingsq~Zt)F:tumor necrosis factor receptor activitysq~ZtF:copper ion bindingsq~ZMtF:protein kinase bindingsq~ZMtF:enzyme bindingsq~Z@t"F:transcription activator activitysq~ZCtF:vinculin bindingsq~ZptF:tumor necrosis factor bindingsq~ZtF:receptor activitysq~ZtF:serotonin receptor activitysq~ZMtF:interleukin-1 bindingsq~ZMtF:interleukin-8 bindingsq~ZMtF:immunoglobulin bindingsq~ZMtF:protein phosphatase bindingsq~Zt$F:transcription corepressor activitysq~Zt/F:thyroid-stimulating hormone receptor activitysq~ZVt0F:eukaryotic translation initiation factor 2a...sq~Zt&F:protein disulfide isomerase activitysq~Z~tF:MHC class I receptor activitysq~Zt%F:ATP-dependent RNA helicase activitysq~ZtF:endoribonuclease activitysq~Z3t#F:protein homodimerization activitysq~ZOtF:endopeptidase activitysq~Z/tF:MHC protein bindingsq~Z=tF:phosphate bindingsq~ZTtF:GTPase activitysq~Z t F:6-phosphofructokinase activitysq~Z{t"F:ubiquitin protein ligase bindingsq~Zit"F:protein-tyrosine kinase activitysq~Zt#F:ubiquitin-protein ligase activitysq~Zt"F:endopeptidase inhibitor activitysq~ZmtF:peptide antigen bindingsq~ZtF:antigen bindingsq~ZtF:nuclease activitysq~ZtF:lactase activitysq~Zut(F:Hsp70/Hsc70 protein regulator activitysq~ZtF:collagen bindingsq~ZotF:enzyme activator activitysq~ZQtF:microtubule bindingsq~Zt F:GTP bindingsq~Zyt0F:RNA polymerase II transcription factor acti...sq~Zvt0F:RNA polymerase II transcription factor acti...sq~ZtF:protease bindingsq~ZtF:glycoprotein bindingsq~ZtF:ATPase activator activitysq~ZtF:DNA strand annealing activitysq~ZtF:magnesium ion bindingsq~Zt%F:protein heterodimerization activitysq~ZǏtF:chaperone bindingsq~ZSt(F:cAMP-dependent protein kinase activitysq~ZtF:transcription factor bindingsq~Zt'F:nuclear localization sequence bindingsq~Z;t/F:kainate selective glutamate receptor activitysq~Z;gt,F:adenine transmembrane transporter activitysq~Zt+F:low-density lipoprotein receptor activitysq~Zt!F:small GTPase regulator activitysq~ZtF:receptor bindingsq~Z:tF:integrin bindingsq~ZNtF:structural molecule activitysq~Z_tF:transporter activitysq~Z!XtF:Ran GTPase bindingsq~Zpt0F:serotonin-activated cation-selective channe...sq~Z )tF:peptidase activitysq~Z=tF:tubulin bindingsq~Z NtF:zinc ion bindingsq~Z *t"F:cysteine-type peptidase activitysq~Zi t C:cytoplasmsq~ZtC:integral to plasma membranesq~ZtC:endoplasmic reticulumsq~ZtC:extracellular regionsq~Zt C:nucleussq~ZtC:intermediate filamentsq~ZtC:membrane fractionsq~ZtC:rufflesq~ZtC:soluble fractionsq~Zt C:endoplasmic reticulum membranesq~ZtC:intracellularsq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zbt C:nucleolussq~Zt0C:eukaryotic translation elongation factor 1 ...sq~ZktC:mitochondrionsq~Z2t C:cell cortexsq~ZtC:cytoskeletonsq~ZWt!C:perinuclear region of cytoplasmsq~Z%tC:focal adhesionsq~ZtC:plasma membranesq~ZtC:Arp2/3 protein complexsq~Zt C:microsomesq~ZtC:Golgi apparatussq~Zt C:cytosolsq~Zt C:microtubule associated complexsq~Zt"C:heterotrimeric G-protein complexsq~Zt+C:proteasome core complex (sensu Eukaryota)sq~Z9tC:6-phosphofructokinase complexsq~ZMtC:extrinsic to membranesq~Z#tC:transcription factor complexsq~ZEtC:Weibel-Palade bodysq~Z|tC:mitochondrial membranesq~ZystC:platelet alpha granulesq~Zy$tC:extracellular matrixsq~Zut,C:integral to endoplasmic reticulum membranesq~ZutC:integral to Golgi membranesq~ZuKtC:lamellipodiumsq~ZtC:protein complexsq~Z?tC:nuclear matrixsq~ZtC:cytoplasmic partsq~ZtC:extracellular spacesq~Z'tC:keratin filamentsq~ZAt C:lipid raftsq~ZtC:insoluble fractionsq~Z tC:nuclear poresq~Zt C:nucleoplasmsq~ZtC:Bcl3/NF-kappaB2 complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~ uq~ sq~t)P:negative regulation of caspase activityt43154sq~tP:anti-apoptosist6916sq~tF:unfolded protein bindingt51082sq~tF:protein binding, bridgingt30674sq~tF:caspase inhibitor activityt43027sq~tF:calcium ion bindingt5509sq~t F:ATP bindingt5524sq~t!C:perinuclear region of cytoplasmt48471sq~t C:nucleust5634sq~t,C:integral to endoplasmic reticulum membranet30176sq~t#C:ER-Golgi intermediate compartmentt5793sq~tC:endoplasmic reticulum lument5788sq~tC:cell surfacet9986pppppppxsq~uq~ sq~t IPR000886t ER_target_Ssq~t IPR001023tHsp70sq~t IPR013126tHsp_70pppppppxsq~uq~ sq~tHSP70tPF00012pppppppppxtP11021t GRP78_HUMANsq~uq~ sq~tGRP 78sq~tHeat shock 70 kDa protein 5sq~t*Immunoglobulin heavy chain-binding proteinsq~tBiPsq~t:Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78pppppxt Homo sapienstVINCsq~P?i@V%tVinculinsq~uq~ sq~U@VtENSG00000035403pppppppppxsq~uq~ sq~m@VtVCLpppppppppxsq~Ruq~ sq~Z@VtP:signal transductionsq~Z@VtP:cell adhesionsq~Z@VtP:focal adhesion formationsq~Z@VtP:cell motilitysq~Z @VtP:RNA splicingsq~Z@VtP:anti-apoptosissq~Z9@VtP:protein foldingsq~Z@Vt(P:nuclear mRNA splicing, via spliceosomesq~Z @Vt P:translationsq~Z@VtP:RNA processingsq~Z@VtP:regulation of apoptosissq~Z@VtP:mRNA processingsq~Z [@VtP:cell proliferationsq~Z@VtP:spliceosome assemblysq~ZJ@VtP:response to unfolded proteinsq~Z@VtP:homophilic cell adhesionsq~Z@Vt0P:cell surface receptor linked signal transdu...sq~Z@VtP:signal complex assemblysq~Z@VtP:muscle contractionsq~Z.@Vt(P:regulation of translational initiationsq~Zk@Vt&P:multicellular organismal developmentsq~ZJ@Vt.P:regulation of progression through cell cyclesq~Z ^@Vt$P:insulin receptor signaling pathwaysq~Z@]@VtP:cell migrationsq~ZH@Vt&P:positive regulation of cell motilitysq~Z!`@VtP:epidermis developmentsq~Z@Vt P:transportsq~Z=@Vt%P:integrin-mediated signaling pathwaysq~Z@a@Vt&P:negative regulation of transcriptionsq~Z:@Vt"P:negative regulation of apoptosissq~Z@VtP:stress fiber formationsq~Z=@VtP:glucose transportsq~Z@VtP:protein import into nucleussq~Z@@VtP:protein modification processsq~Z@Vt,P:melanin biosynthetic process from tyrosinesq~Zo@Vt/P:ubiquitin-dependent protein catabolic processsq~Zl@Vt P:proteolysissq~Zm@Vt)P:membrane protein ectodomain proteolysissq~Z@VtP:translational elongationsq~ZD@Vt$P:protein amino acid phosphorylationsq~Z@VtP:mRNA polyadenylationsq~Z:@VtP:protein transportsq~Z=5@VtP:gas transportsq~Z=f@VtP:monocarboxylic acid transportsq~Z?@@VtP:vesicle-mediated transportsq~Z@@VtP:chromatin modificationsq~Z@@VtP:protein ubiquitinationsq~Z!@VtP:apical junction assemblysq~ZF@Vt#P:peptidyl-tyrosine phosphorylationsq~Z'@VtP:response to X-raysq~Z'@Vt$P:response to extracellular stimulussq~Z@Vt,P:regulation of transcription, DNA-dependentsq~Z@Vt$P:DNA fragmentation during apoptosissq~Z@VtP:double-strand break repairsq~Z@Vt P:glycolysissq~Z@Vt%P:glycosaminoglycan catabolic processsq~Z%@VtP:response to woundingsq~Z%@VtP:UV protectionsq~Z%@Vt$P:anatomical structure morphogenesissq~Z@Vt0P:Wnt receptor signaling pathway through beta...sq~Z@VtP:protein retention in ERsq~Z@VtP:lipid metabolic processsq~Z@Vt0P:transmembrane receptor protein tyrosine kin...sq~Z!@Vt0P:induction of apoptosis by extracellular sig...sq~ZK@VtP:protein kinase cascadesq~Z`@Vt+P:small GTPase mediated signal transductionsq~Zd@VtP:synaptic transmissionsq~Zs@VtP:spermatogenesissq~Z@VtP:axon guidancesq~Z@Vt$P:central nervous system developmentsq~Z_@VtP:striated muscle developmentsq~ZP@Vt!P:regulation of heart contractionsq~Z#@Vt.P:nucleoside triphosphate biosynthetic processsq~Z!@Vt%P:caspase activation via cytochrome csq~Z!@Vt.P:release of cytoplasmic sequestered NF-kappaBsq~Z@Vt.P:actin polymerization and/or depolymerizationsq~Z ]@Vt+P:negative regulation of cell proliferationsq~Z @VtP:regulation of cell shapesq~Z@Vt*P:calcium-independent cell-matrix adhesionsq~Z$@VtP:response to coldsq~Z@VtP:fatty acid beta-oxidationsq~Z@Vt!P:mitochondrial citrate transportsq~Z@VtP:cellular iron ion homeostasissq~Z@Vt!P:intracellular protein transportsq~Z@Vt P:exocytosissq~Z@Vt P:apoptosissq~Z@Vt!P:intercellular junction assemblysq~Z@VtP:induction of apoptosissq~Z@VtP:caspase activationsq~Z@VtP:striated muscle contractionsq~Z*@VtP:inflammatory responsesq~Z8@VtP:cellular defense responsesq~ZU@Vt%P:nuclear organization and biogenesissq~Zh@VtP:cytoskeletal anchoringsq~Zv@Vt#P:Golgi organization and biogenesissq~Z@Vt P:cell cyclesq~Za@Vt!P:Ras protein signal transductionsq~ZuS@VtP:microspike biogenesissq~ZV@Vt'P:G2/M transition of mitotic cell cyclesq~Zr@Vt%P:regulation of epidermis developmentsq~Z@VtP:cell cycle arrestsq~Z2@Vt0P:positive regulation of keratinocyte differe...sq~Z@VtP:cellular respirationsq~Z@Vt)P:blood vessel endothelial cell migrationsq~Z@VtP:skeletal developmentsq~Zs@Vt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z@Vt%P:regulation of macrophage activationsq~Z@VtP:muscle cell differentiationsq~Z@Vt'P:regulation of RNA export from nucleussq~Z@VtP:response to drugsq~Z@Vt+P:natural killer cell mediated cytotoxicitysq~ZN@Vt0P:long-term strengthening of neuromuscular ju...sq~ZE@Vt0P:positive regulation of transcription, DNA-d...sq~Zu@Vt&P:positive regulation of transcriptionsq~ZY@VtP:protein homotetramerizationsq~Z@Vt P:cytokinesissq~Z@Vt$P:prostaglandin biosynthetic processsq~Z@VtP:angiogenesissq~ZG@Vt&P:negative regulation of cell motilitysq~Z-@Vt&P:epithelial to mesenchymal transitionsq~ZH@Vt#P:barbed-end actin filament cappingsq~ZF@VtP:actin filament severingsq~Z@VtP:leukocyte migrationsq~Z@Vt0P:positive regulation of epithelial cell prol...sq~Z@VtP:mRNA stabilizationsq~Z'@Vt#P:regulation of synaptic plasticitysq~Z@Vt%P:phosphoinositide-mediated signalingsq~Z~@Vt0P:positive regulation of sodium:hydrogen anti...sq~Zu`@VtP:actin filament-based movementsq~Zv@Vt)P:ER-associated protein catabolic processsq~Zv@Vt'P:positive regulation of cell migrationsq~Zv @VtP:erythrocyte differentiationsq~Zv @VtP:muscle thin filament assemblysq~Zv@VtP:monocyte differentiationsq~Zv @VtP:platelet formationsq~Zu@VtP:cell differentiationsq~ZuY@VtP:actin filament polymerizationsq~Zua@VtP:muscle filament slidingsq~Zw9@Vt%P:androgen receptor signaling pathwaysq~ZuT@Vt0P:actin cytoskeleton organization and biogenesissq~Z{,@Vt#P:actin cytoskeleton reorganizationsq~Zt@VtP:DNA replicationsq~Z:@VtF:protein bindingsq~Z @Vt F:RNA bindingsq~Z@VtF:calcium ion bindingsq~Z@Vt$F:structural constituent of ribosomesq~ZP@Vt(F:structural constituent of cytoskeletonsq~Z@VtF:actin bindingsq~ZC@VtF:vinculin bindingsq~Z@Vt F:ATP bindingsq~ZNJ@VtF:unfolded protein bindingsq~Z3@Vt#F:protein homodimerization activitysq~Z]@Vt F:DNA bindingsq~Z@VtF:SH3/SH2 adaptor activitysq~Z:@VtF:integrin bindingsq~Z s@Vt"F:structural constituent of musclesq~Z N@VtF:zinc ion bindingsq~Z@Vt F:GTP bindingsq~Z@@Vt"F:transcription repressor activitysq~Z@VtF:collagen bindingsq~Z2@VtF:identical protein bindingsq~Z&@VtF:insulin receptor bindingsq~Zp@Vt F:bindingsq~ZG@VtF:actin filament bindingsq~Zj@VtF:double-stranded DNA bindingsq~ZB~@VtF:myosin bindingsq~Z @VtF:heparin bindingsq~Z@Vt%F:ATP-dependent RNA helicase activitysq~Zb@VtF:lipoprotein bindingsq~Zi@Vt"F:protein-tyrosine kinase activitysq~Z@VtF:receptor activitysq~Z@Vt(F:translation initiation factor activitysq~Z@VtF:poly(A) bindingsq~Z@VtF:SH2 domain bindingsq~Z@VtF:signal transducer activitysq~ZM@VtF:kinase bindingsq~ZNE@VtF:heme bindingsq~Z!Z@VtF:proteasome activator activitysq~Z0@VtF:MHC class I protein bindingsq~ZȪ@VtF:ZASP bindingsq~ZǏ@VtF:chaperone bindingsq~ZB@VtF:5'-flap endonuclease activitysq~ZM@VtF:protein kinase bindingsq~ZȮ@VtF:FATZ 1 bindingsq~Zȫ@VtF:muscle alpha-actinin bindingsq~Z!.@Vt F:translation activator activitysq~ZA@VtF:ATPase activitysq~Z@VtF:protein anchorsq~Z>@Vt*F:low-density lipoprotein receptor bindingsq~Z;!@Vt,F:citrate transmembrane transporter activitysq~Z@VtF:ribosome bindingsq~ZB@VtF:SH3 domain bindingsq~Z@Vt0F:ATPase activity, coupled to transmembrane m...sq~Z@VtF:ATPase activity, coupledsq~Zw@@Vt"F:transcription regulator activitysq~Z @Vt F:ADP bindingsq~Z;g@Vt,F:adenine transmembrane transporter activitysq~ZA@Vt F:prolyl aminopeptidase activitysq~Zc@Vt0F:electron transporter, transferring electron...sq~Z@VtF:androgen receptor bindingsq~Zu@VtF:manganese ion bindingsq~Z@VtF:protein dimerization activitysq~Zv@Vt"F:thyroid hormone receptor bindingsq~Z?@Vt/F:protein-arginine N-methyltransferase activitysq~ZvB@VtF:LIM domain bindingsq~Zx@Vt!F:actin-dependent ATPase activitysq~Z @VtF:5'-3' exonuclease activitysq~Z@VtF:laminin receptor activitysq~Z@VtF:phospholipase C activitysq~Z @Vt"F:phosphoglycerate mutase activitysq~Z@VtF:alpha-L-fucosidase activitysq~Z@Vt(F:nucleoside diphosphate kinase activitysq~Zk@Vt"F:L-lactate dehydrogenase activitysq~ZQ@Vt-F:extracellular matrix structural constituentsq~Z @Vt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~Z@VtF:enoyl-CoA hydratase activitysq~Z@VtF:lipid transporter activitysq~ZR@Vt F:leucyl aminopeptidase activitysq~ZG@VtF:dopachrome isomerase activitysq~Z@Vt%F:ATP-dependent DNA helicase activitysq~Z@Vt'F:acetyl-CoA C-acyltransferase activitysq~ZT@VtF:GTPase activitysq~ZY@VtF:protein kinase C activitysq~Z@Vt#F:ubiquitin-protein ligase activitysq~Z@Vt"F:phospholipase inhibitor activitysq~Z@Vt%F:receptor signaling protein activitysq~Z@Vt,F:guanyl-nucleotide exchange factor activitysq~Z@VtF:receptor bindingsq~Z@VtF:cytokine activitysq~Z@Vt F:interleukin-1 receptor bindingsq~ZN@VtF:structural molecule activitysq~Z@VtF:scavenger receptor activitysq~Z@VtF:transferrin receptor activitysq~Z @Vt&F:asialoglycoprotein receptor activitysq~Z_@VtF:transporter activitysq~Z@VtF:copper ion bindingsq~Z@VtF:calmodulin bindingsq~Z@VtF:lamin bindingsq~Z@Vt.F:serine-type endopeptidase inhibitor activitysq~Z@Vt*F:3-hydroxyacyl-CoA dehydrogenase activitysq~Ze@Vt&F:cysteine-type endopeptidase activitysq~Z@Vt$F:transcription coactivator activitysq~Z@VtF:cytoskeletal adaptor activitysq~Z\@Vt0F:monocarboxylic acid transmembrane transport...sq~ZV@VtF:protein C-terminus bindingsq~Z@VtF:ribonuclease H activitysq~ZZ@VtF:nucleoside bindingsq~Z@VtF:nucleotide bindingsq~Z@VtF:magnesium ion bindingsq~ZS@VtF:RNA cap bindingsq~Z@VtF:microfilament motor activitysq~Z@VtF:transcription factor bindingsq~Zd@VtF:damaged DNA bindingsq~Z@Vt&F:protein disulfide isomerase activitysq~Z@VtF:RNA helicase activitysq~Z@VtF:motor activitysq~Z u@Vt0F:double-stranded DNA specific exodeoxyribonu...sq~ZZ@Vt!F:ATP-dependent helicase activitysq~Zt@VtF:transcription factor activitysq~Zq@VtF:single-stranded DNA bindingsq~Z J@VtF:poly(U) bindingsq~Z@Vt C:nucleussq~Zi@Vt C:cytoplasmsq~Z@Vt C:cytosolsq~Z1@Vt C:spliceosomesq~Z@VtC:plasma membranesq~Z@VtC:integral to plasma membranesq~Z%@VtC:focal adhesionsq~Z@VtC:membrane fractionsq~Z>@VtC:integral to membranesq~Z@VtC:rufflesq~Z@VtC:cytoskeletonsq~Z@Vt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZwB@Vt0C:heterogeneous nuclear ribonucleoprotein com...sq~ZwD@Vt)C:small nuclear ribonucleoprotein complexsq~Z@VtC:stress fibersq~Z@VtC:actin filamentsq~Z= @VtC:actin cytoskeletonsq~Z@Vt&C:proteasome complex (sensu Eukaryota)sq~Z@VtC:extracellular regionsq~Zy@VtC:pseudopodiumsq~Z@VtC:endoplasmic reticulumsq~ZuK@VtC:lamellipodiumsq~Z@VtC:intracellularsq~Z@Vt#C:ER-Golgi intermediate compartmentsq~Z>@Vt C:membranesq~Zb@Vt C:nucleolussq~Z$@Vt"C:cell-substrate adherens junctionsq~ZA@Vt C:lipid raftsq~Zu@Vt C:filopodiumsq~Z@VtC:protein complexsq~Z@Vt%C:protein phosphatase type 2A complexsq~Z:@Vt C:Cajal bodysq~Z@VtC:dendritic spinesq~ZW@Vt!C:perinuclear region of cytoplasmsq~Z@VtC:postsynaptic membranesq~Z!Y@VtC:proteasome activator complexsq~Z?@Vt0C:eukaryotic translation initiation factor 4F...sq~Z?@VtC:lateral plasma membranesq~Z@M@VtC:unconventional myosin complexsq~Z@VtC:striated muscle thin filamentsq~Z@Vt0C:eukaryotic translation elongation factor 1 ...sq~Z@Vt0C:eukaryotic translation initiation factor 3 ...sq~Z@Vt C:polysomesq~Z@VtC:contractile ringsq~Z@Vt C:microtubule associated complexsq~Z@VtC:intermediate filamentsq~Z>@Vt$C:cytoplasmic membrane-bound vesiclesq~Z'@VtC:muscle tendon junctionsq~Z'@VtC:cell surfacesq~Z@VtC:fascia adherenssq~Z@VtC:zonula adherenssq~Z0@VtC:endomembrane systemsq~Z@VtC:cell-cell adherens junctionsq~Z@VtC:intercellular junctionsq~Z@VtC:Arp2/3 protein complexsq~Z@Vt C:centrosomesq~Z@VtC:trans-Golgi networksq~Z@VtC:extracellular spacesq~Z@VtC:collagen type VIIIsq~ZwA@VtC:ribonucleoprotein complexsq~Zx@Vt"C:beta-catenin destruction complexsq~Z@Vt$C:proteinaceous extracellular matrixsq~Z}@VtC:cleavage furrowsq~Z@VtC:paraspecklessq~Z@Vt C:melanosomesq~Z@VtC:soluble fractionsq~Z@VtC:nuclear envelopesq~Z@Vt C:nucleoplasmsq~Z@VtC:Golgi apparatussq~Z@Vt C:microsomesq~Z@Vt C:endosomesq~Z~@Vt#C:mitochondrial intermembrane spacesq~Zo@VtC:mitochondrial inner membranesq~Zl@VtC:mitochondrial envelopesq~Zk@VtC:mitochondrionsq~Zu@VtC:clathrin coatsq~Zz@Vt0C:mitochondrial proton-transporting ATP synth...ppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~ uq~ sq~@Vt'P:negative regulation of cell migrationt30336sq~@VtP:lamellipodium biogenesist30032sq~@VtP:cell adhesiont7155sq~@VtP:apical junction assemblyt43297sq~@VtF:oxidoreductase activityt16491sq~@VtF:alpha-catenin bindingt45294sq~@VtC:protein complext43234sq~@VtC:intercellular junctiont5911sq~@VtC:focal adhesiont5925sq~@VtC:cytoskeletont5856sq~@Vt C:costameret43034pppppppppxsq~uq~ sq~@Vt IPR006077tVinculin/cateninsq~@Vt IPR000633t Vinculin_2ppppppppxsq~uq~ sq~@VtVinculintPF01044pppppppppxtP18206t VINC_HUMANsq~uq~ sq~@Vt Metavinculinpppppppppxt Homo sapienstSTX11sq~P?A) Kn %t Syntaxin-11sq~uq~ sq~UKntENSG00000135604pppppppppxsq~uq~ sq~mKntSTX11pppppppppxsq~uq~ (sq~ZOKnt0P:regulation of cyclin-dependent protein kina...sq~ZKntP:chromatin remodelingsq~ZKnt0P:regulation of transcription from RNA polyme...sq~ZKnt/P:transcription from RNA polymerase II promotersq~ZKnt'P:post-Golgi vesicle-mediated transportsq~ZKnt P:endocytosissq~ZKntP:vesicle targetingsq~Z KntP:membrane fusionsq~Z>Knt,P:synaptic vesicle docking during exocytosissq~ZlKnt!P:regulation of insulin secretionsq~ZKntP:neurotransmitter uptakesq~ZKntF:protein bindingsq~ZKnt$F:transcription coactivator activitysq~ZKnt$F:transcription corepressor activitysq~Z]Knt F:DNA bindingsq~ZKnt&C:proteasome complex (sensu Eukaryota)sq~ZiKnt C:cytoplasmsq~ZKnt C:nucleussq~ZKntC:integral to plasma membranesq~ZvKntC:histone deacetylase complexsq~ZKntC:plasma membranepppppppppppppppppppxsq~uq~ sq~KntP:membrane fusiont6944sq~KntF:SNAP receptor activityt5484ppppppppxsq~uq~ sq~Knt IPR006012t Syntaxin_coilsq~Knt IPR006011t Syntaxin_Nsq~Knt IPR000727tT_SNAREpppppppxsq~uq~ sq~KntSNAREtPF05739sq~KntSyntaxintPF00804ppppppppxtO75558t STX11_HUMANpt Homo sapienstTRAF6sq~P?MczT{%t TNF receptor-associated factor 6sq~uq~ sq~UTtENSG00000175104pppppppppxsq~uq~ sq~mTtTRAF6sq~mTtRNF85ppppppppxsq~uq~ sq~ZTtP:signal transductionsq~Zs Tt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z Tt P:translationsq~Z TtP:cell motilitysq~Z [ TtP:cell proliferationsq~Zo Tt/P:ubiquitin-dependent protein catabolic processsq~Z TtP:anti-apoptosissq~Z9 TtP:protein foldingsq~ZD Tt$P:protein amino acid phosphorylationsq~ZJTt.P:regulation of progression through cell cyclesq~ZTt0P:cell surface receptor linked signal transdu...sq~Z&TtP:response to stresssq~ZtTtP:DNA replicationsq~ZJTtP:response to unfolded proteinsq~ZTt0P:G-protein coupled receptor protein signalin...sq~ZTt0P:regulation of transcription from RNA polyme...sq~Z=TtP:protein complex assemblysq~ZRTt)P:activation of NF-kappaB-inducing kinasesq~Z@TtP:protein ubiquitinationsq~ZFTt&P:protein amino acid dephosphorylationsq~Z@TtP:protein modification processsq~Z.Tt(P:regulation of translational initiationsq~ZTt0P:nucleobase, nucleoside, nucleotide and nucl...sq~Z ]Tt+P:negative regulation of cell proliferationsq~ZTtP:cell cycle arrestsq~ZTt/P:transcription from RNA polymerase II promotersq~Z+TtP:immune responsesq~Z*TtP:inflammatory responsesq~ZTt P:apoptosissq~ZTt!P:intracellular protein transportsq~ZKTtP:protein kinase cascadesq~ZƤTt#P:T cell receptor signaling pathwaysq~Z!`TtP:epidermis developmentsq~ZTtP:induction of apoptosissq~ZƶTt*P:positive regulation of T cell activationsq~Z(TtP:defense responsesq~Z \Tt+P:positive regulation of cell proliferationsq~Z Tt0P:positive regulation of T cell cytokine prod...sq~ZTt P:DNA repairsq~ZzTt0P:negative regulation of transcription from R...sq~ZTtP:nucleosome assemblysq~ZTtP:mRNA processingsq~Z TtP:translational initiationsq~ZTtP:electron transportsq~ZǔTt.P:activation of NF-kappaB transcription factorsq~ZTt P:glycolysissq~ZlTt P:proteolysissq~ZTtP:lipid metabolic processsq~Z`Tt+P:small GTPase mediated signal transductionsq~ZWTt P:carbohydrate metabolic processsq~ZuTTt0P:actin cytoskeleton organization and biogenesissq~ZTt P:cell cyclesq~ZTt0P:positive regulation of gene-specific transc...sq~ZDTt0P:negative regulation of transcription, DNA-d...sq~ZTt(P:protein amino acid autophosphorylationsq~ZuTt&P:positive regulation of transcriptionsq~ZQTt#P:I-kappaB kinase/NF-kappaB cascadesq~ZTt%P:phosphoinositide-mediated signalingsq~ZvTt)P:ER-associated protein catabolic processsq~ZxTt0P:positive regulation of transcription from R...sq~ZTtP:anion transportsq~Zw9Tt%P:androgen receptor signaling pathwaysq~ZTt P:transportsq~ZTt P:endocytosissq~ZTtP:nucleocytoplasmic transportsq~ZTtP:protein export from nucleussq~ZTtP:regulation of apoptosissq~ZOTt P:protein amino acid methylationsq~ZTt0P:regulation of interleukin-12 biosynthetic p...sq~ZTtP:caspase activationsq~ZTtP:translational elongationsq~ZTtP:RNA processingsq~ZTt P:chemotaxissq~ZTtP:DNA recombinationsq~ZtTt0P:negative regulation of I-kappaB kinase/NF-k...sq~ZTtP:cell adhesionsq~ZITt!P:actin filament bundle formationsq~ZȍTt'P:regulation of oxidoreductase activitysq~ZKTt0P:cytokine and chemokine mediated signaling p...sq~ZTtP:nervous system developmentsq~ZTtP:spermatid differentiationsq~Z[TtP:protein heterooligomerizationsq~Z;TtP:protein oligomerizationsq~Z TtP:RNA splicingsq~ZTt$P:DNA double-strand break processingsq~ZTtP:activation of MAPKKK activitysq~Z>xTtP:proton transportsq~Z:TtP:protein transportsq~ZgTt0P:negative regulation of osteoclast different...sq~ZTtP:protein localizationsq~ZRTt'P:G1/S transition of mitotic cell cyclesq~ZTt$P:prostaglandin biosynthetic processsq~Z!Tt%P:caspase activation via cytochrome csq~Z#TtP:threonyl-tRNA aminoacylationsq~ZTtP:regulation of translationsq~Z@TtP:protein deubiquitinationsq~ZTtP:tRNA modificationsq~Z&TtP:organ morphogenesissq~ZFTt#P:peptidyl-tyrosine phosphorylationsq~ZTtP:nucleotide-excision repairsq~Z'1TtP:response to organic substancesq~ZTtP:mRNA polyadenylationsq~Z%TtP:tyrosyl-tRNA aminoacylationsq~ZTtP:protein targetingsq~ZTtP:glutamate catabolic processsq~Z#Tt.P:ribonucleoside diphosphate catabolic processsq~ZnTtP:ATP-dependent proteolysissq~Z$ZTtP:protein secretionsq~ZJTt+P:N-terminal protein amino acid acetylationsq~ZGTt%P:protein amino acid ADP-ribosylationsq~ZTt0P:negative regulation of tyrosine phosphoryla...sq~ZETt0P:negative regulation of protein kinase activitysq~Z%}TtP:detection of virussq~Z%Tt$P:anatomical structure morphogenesissq~Z&>TtP:embryonic developmentsq~Z%TtP:response to virussq~Z1Tt)P:regulation of translational terminationsq~Z#TtP:nucleotide metabolic processsq~ZTt0P:transcription initiation from RNA polymeras...sq~ZaTtP:CTP biosynthetic processsq~ZETt)P:pyrimidine nucleoside metabolic processsq~Z-Tt$P:'de novo' IMP biosynthetic processsq~ZTtP:purine ribonucleoside salvagesq~ZTt(P:purine nucleotide biosynthetic processsq~Z?ETtP:endosome transportsq~Z?JTt+P:regulation of striated muscle developmentsq~ZTt0P:tricarboxylic acid cycle intermediate metab...sq~Z?TtP:dephosphorylationsq~Z?TtP:cell-cell adhesionsq~ZuYTtP:actin filament polymerizationsq~ZuTtP:protein repairsq~Z@aTt&P:negative regulation of transcriptionsq~ZuTt.P:regulation of Wnt receptor signaling pathwaysq~Z>TtP:mRNA metabolic processsq~Z|Tt"P:DNA unwinding during replicationsq~Z~TtP:DNA replication initiationsq~Z@TtP:histone ubiquitinationsq~Z=pTtP:mevalonate transportsq~ZTt,P:regulation of transcription, DNA-dependentsq~ZTtP:transcriptionsq~ZTtP:nucleosome disassemblysq~ZTt$P:DNA fragmentation during apoptosissq~ZTtP:double-strand break repairsq~ZTtP:postreplication repairsq~ZTtP:mismatch repairsq~ZTt$P:base-excision repair, DNA ligationsq~ZTtP:base-excision repairsq~ZTtP:regulation of DNA repairsq~Z>Tt P:cell growthsq~ZTtP:regulation of DNA replicationsq~ZuTtP:regulation of cell adhesionsq~ZaTt!P:Ras protein signal transductionsq~ZTtP:cell-matrix adhesionsq~ZTtP:leukocyte adhesionsq~ZTtP:centrosome cyclesq~ZTt P:cell agingsq~ZTtP:visual perceptionsq~ZTtP:mitotic cell cycle checkpointsq~ZTtP:regulation of mitosissq~ZTtP:sensory perception of soundsq~ZTt-P:mitotic spindle organization and biogenesissq~ZTt)P:sensory perception of chemical stimulussq~ZTt P:behaviorsq~ZuPTtP:lamellipodium biogenesissq~ZjTtP:microtubule-based movementsq~ZPTt!P:regulation of heart contractionsq~ZTt0P:establishment and/or maintenance of cell po...sq~Z]TtP:muscle developmentsq~ZTtP:axon guidancesq~ZYTtP:activation of JNK activitysq~ZVTt P:JNK cascadesq~ZcTtP:cell-cell signalingsq~ZdTtP:synaptic transmissionsq~ZkTt&P:multicellular organismal developmentsq~ZsTtP:spermatogenesissq~Z=Tt%P:integrin-mediated signaling pathwaysq~ZTt0P:negative regulation of adenylate cyclase ac...sq~ZTtP:single fertilizationsq~Z Tt0P:transforming growth factor beta receptor si...sq~Z Tt0P:transmembrane receptor protein serine/threo...sq~ZTt0P:epidermal growth factor receptor signaling ...sq~ZTtP:signal complex assemblysq~ZTt0P:transmembrane receptor protein tyrosine kin...sq~ZhTtP:cytoskeletal anchoringsq~ZTt0P:regulation of actin polymerization and/or d...sq~Z?Tt,P:DNA damage induced protein phosphorylationsq~ZTt"P:cellular calcium ion homeostasissq~ZiTtP:microtubule-based processsq~ZTtP:potassium ion transportsq~Z!Tt0P:DNA damage response, signal transduction re...sq~ZJTt'P:one-carbon compound metabolic processsq~ZTtP:ceramide metabolic processsq~ZTtP:sphingosine metabolic processsq~Z!TtP:apoptotic programsq~ZTt+P:phosphatidylinositol biosynthetic processsq~ZTtP:fatty acid beta-oxidationsq~Z#[Tt+P:pentose-phosphate shunt, oxidative branchsq~ZTt/P:cotranslational protein targeting to membranesq~Z#Tt"P:purine base biosynthetic processsq~ZTt+P:NLS-bearing substrate import into nucleussq~ZTtP:cellular iron ion homeostasissq~Z!Tt0P:induction of apoptosis by intracellular sig...sq~ZTt(P:ER to Golgi vesicle-mediated transportsq~Z>Tt!P:response to DNA damage stimulussq~Z<TtP:hyperosmotic responsesq~ZTt&P:establishment of blood-nerve barriersq~Z)TtP:acute-phase responsesq~ZTt(P:negative regulation of DNA replicationsq~ZMTt%P:second-messenger-mediated signalingsq~ZTtP:muscle contractionsq~ZM TtP:calcium-mediated signalingsq~ZKgTtP:D-ribose catabolic processsq~Z!TtP:male gonad developmentsq~Z!Tt0P:induction of apoptosis by extracellular sig...sq~Z!Tt0P:induction of apoptosis via death domain rec...sq~ZTtP:receptor-mediated endocytosissq~ZTtP:Golgi to endosome transportsq~ZTtP:protein import into nucleussq~ZTt%P:regulation of macrophage activationsq~ZTtP:bone resorptionsq~ZTtP:cell redox homeostasissq~ZTt$P:regulation of cell differentiationsq~ZTt#P:positive regulation of DNA repairsq~ZTt%P:positive regulation of angiogenesissq~ZETt0P:positive regulation of transcription, DNA-d...sq~ZkTt0P:positive regulation of progression through ...sq~ZTt0P:positive regulation of dopamine metabolic p...sq~ZTt0P:positive regulation of smooth muscle contra...sq~ZTt P:hypoxanthine metabolic processsq~ZTt$P:negative regulation of JNK cascadesq~ZTt$P:positive regulation of JNK cascadesq~ZTtP:sphingoid catabolic processsq~ZTtP:regulation of transcriptionsq~Z/Tt0P:positive regulation of interferon-beta bios...sq~Z,Tt0P:positive regulation of interferon-alpha bio...sq~Z:Tt"P:negative regulation of apoptosissq~Z=Tt.P:negative regulation of programmed cell deathsq~ZrTt0P:regulation of I-kappaB kinase/NF-kappaB cas...sq~ZxTt0P:positive regulation of 1-phosphatidylinosit...sq~ZTt)P:negative regulation of caspase activitysq~ZTt0P:proteasomal ubiquitin-dependent protein cat...sq~ZTt+P:regulation of protein complex disassemblysq~ZTt'P:positive regulation of MAPKKK cascadesq~ZTt0P:negative regulation of transcription factor...sq~ZTtP:histone exchangesq~ZTt0P:positive regulation of interferon-gamma bio...sq~ZTt0P:negative regulation of chemokine biosynthet...sq~ZTtP:cellular respirationsq~ZTt0P:virion attachment, binding of host cell sur...sq~ZTt+P:mitochondrion transport along microtubulesq~ZǝTtP:regulation of DNA bindingsq~ZTtP:nuclear exportsq~ZTtP:telomere maintenancesq~ZTt(P:nuclear mRNA splicing, via spliceosomesq~ZYTtP:protein homotetramerizationsq~ZTtP:protein polyubiquitinationsq~ZTtP:inactivation of MAPK activitysq~ZTtP:activation of MAPK activitysq~ZTt0P:mRNA catabolic process, nonsense-mediated d...sq~ZTtP:MAPKKK cascadesq~ZTtP:stress-activated MAPK cascadesq~ZTt0P:positive regulation of ubiquitin ligase act...sq~ZsTt0P:S-phase-specific transcription in mitotic c...sq~ZTtP:skeletal developmentsq~ZTtP:regulation of cell growthsq~ZTtP:mesoderm formationsq~ZnTt%P:chaperonin-mediated tubulin foldingsq~ZTt0P:positive regulation of fibroblast prolifera...sq~Z'Tt#P:regulation of synaptic plasticitysq~ZcTt'P:plasma membrane to endosome transportsq~ZTtP:mRNA stabilizationsq~ZTt0P:positive regulation of receptor mediated en...sq~ZTt0P:negative regulation of receptor mediated en...sq~Z+Tt0P:positive regulation of peptidyl-tyrosine ph...sq~Z Tt P:histone mRNA metabolic processsq~Z<Tt,P:protein import into nucleus, translocationsq~ZTt0P:negative regulation of cytokine and chemoki...sq~Z-Tt&P:epithelial to mesenchymal transitionsq~Z TtP:blastocyst developmentsq~ZOTt0P:regulation of cyclin-dependent protein kina...sq~ZxTtP:unfolded protein responsesq~ZtTtP:B cell proliferationsq~ZTt)P:retrograde transport, endosome to Golgisq~ZxTt-P:retrograde protein transport, ER to cytosolsq~ZwTtP:neutrophil chemotaxissq~ZTtP:ribosome assemblysq~ZTt+P:natural killer cell mediated cytotoxicitysq~ZUTtP:regulation of phosphorylationsq~ZTtP:response to drugsq~Zw-TtP:BMP signaling pathwaysq~ZNTt0P:long-term strengthening of neuromuscular ju...sq~ZTt,P:negative regulation of histone acetylationsq~ZyRTt-P:positive regulation of histone modificationsq~ZyTt0P:negative regulation of microtubule polymeri...sq~ZyTtP:rRNA pseudouridine synthesissq~Zz*Tt/P:positive regulation of pseudopodium formationsq~ZzeTt0P:negative regulation of protein complex asse...sq~Z{)Tt$P:ruffle organization and biogenesissq~Z{Tt0P:negative regulation of lipopolysaccharide-m...sq~Z}Tt'P:activation of protein kinase activitysq~ZTt0P:positive regulation of Rho protein signal t...sq~ZvTt'P:positive regulation of cell migrationsq~ZvlTtP:osteoclast differentiationsq~ZvcTt$P:positive regulation of cell growthsq~ZTtP:defense response to bacteriumsq~ZvdTt$P:negative regulation of cell growthsq~ZTtP:cholesterol homeostasissq~ZuTtP:neuron differentiationsq~ZvTtP:macrophage differentiationsq~Zv]TtP:cholesterol transportsq~ZuTtP:platelet activationsq~ZvFTtP:regulation of ossificationsq~ZTtF:protein bindingsq~ZTt F:RNA bindingsq~ZTt F:ATP bindingsq~ZTtF:signal transducer activitysq~Z Tt$F:structural constituent of ribosomesq~ZT TtF:GTPase activitysq~ZNJ TtF:unfolded protein bindingsq~Z] Tt F:DNA bindingsq~ZTtF:magnesium ion bindingsq~Z2TtF:identical protein bindingsq~ZTtF:receptor activitysq~ZATtF:ATPase activitysq~ZTt#F:ubiquitin-protein ligase activitysq~ZTt(F:translation initiation factor activitysq~Z NTtF:zinc ion bindingsq~Z3Tt#F:protein homodimerization activitysq~ZtTtF:transcription factor activitysq~ZoTtF:enzyme activator activitysq~ZTtF:calcium ion bindingsq~ZTt0F:translation factor activity, nucleic acid b...sq~Z_TtF:transporter activitysq~ZTt F:GTP bindingsq~ZTt$F:transcription coactivator activitysq~ZTt%F:ATP-dependent RNA helicase activitysq~ZdTtF:MAP kinase kinase activitysq~ZBTt*F:protein serine/threonine kinase activitysq~ZTt$F:transcription corepressor activitysq~ZTtF:actin bindingsq~ZTt%F:ATP-dependent DNA helicase activitysq~ZPTt(F:structural constituent of cytoskeletonsq~ZTt)F:tumor necrosis factor receptor activitysq~ZqTtF:single-stranded DNA bindingsq~Z!Tt0F:protein phosphatase type 2A regulator activitysq~ZiTt"F:protein-tyrosine kinase activitysq~ZVTtF:protein C-terminus bindingsq~ZwTtF:protein binding, bridgingsq~Z#_TtF:electron carrier activitysq~ZTt%F:protein heterodimerization activitysq~ZeTt#F:MAP kinase kinase kinase activitysq~ZTt%F:translation release factor activitysq~ZA Tt0F:oxidoreductase activity, acting on NADH or ...sq~ZTtF:mRNA bindingsq~ZY<Tt&F:voltage-gated anion channel activitysq~ZSTtF:RNA cap bindingsq~Z TtF:3'-5' exonuclease activitysq~ZjTtF:double-stranded DNA bindingsq~Z!XTtF:Ran GTPase bindingsq~ZGTtF:actin filament bindingsq~ZMTtF:enzyme bindingsq~ZMTtF:protein kinase bindingsq~ZvTt0F:RNA polymerase II transcription factor acti...sq~ZTtF:poly(A) bindingsq~ZuTt'F:protein tyrosine phosphatase activitysq~Z+TtF:interleukin receptor activitysq~ZTt!F:transmembrane receptor activitysq~Z!TtF:cytochrome-c oxidase activitysq~ZOTtF:endopeptidase activitysq~Z}Tt"F:ubiquitin thiolesterase activitysq~ZTtF:ATPase activity, coupledsq~ZTtF:enoyl-CoA hydratase activitysq~Z Tt"F:glutathione transferase activitysq~ZTtF:calmodulin bindingsq~Z@TtF:protein kinase activitysq~ZeTtF:protein self-associationsq~ZTtF:SH2 domain bindingsq~Z`Tt$F:NF-kappaB-inducing kinase activitysq~ZBTt%F:G-protein coupled receptor activitysq~ZzTtF:ubiquitin bindingsq~ZQTtF:microtubule bindingsq~ZNTtF:structural molecule activitysq~ZTtF:double-stranded RNA bindingsq~ZTtF:caspase inhibitor activitysq~Z@kTtF:oxidoreductase activitysq~ZuTtF:manganese ion bindingsq~ZvTt0F:ligand-dependent nuclear receptor transcrip...sq~Z@Tt-F:specific transcriptional repressor activitysq~ZcTt0F:electron transporter, transferring electron...sq~ZTtF:histone bindingsq~ZǏTtF:chaperone bindingsq~Z9TtF:vitamin D receptor bindingsq~Zw3TtF:snoRNA bindingsq~ZWTt F:NAD bindingsq~ZuTtF:chaperone regulator activitysq~Zv{TtF:estrogen receptor bindingsq~ZvBTtF:LIM domain bindingsq~ZATt0F:monodehydroascorbate reductase (NADH) activitysq~ZTtF:ribosome bindingsq~ZTtF:ATP-dependent protein bindingsq~ZBTt'F:D-erythro-sphingosine kinase activitysq~Z@Tt"F:transcription activator activitysq~ZBTt$F:nucleoside-triphosphatase activitysq~Z@Tt"F:transcription repressor activitysq~Zw@Tt"F:transcription regulator activitysq~Zw_Tt'F:rRNA pseudouridylation guide activitysq~Z0TtF:MHC class I protein bindingsq~ZMTtF:syntaxin bindingsq~ZTtF:S100 beta bindingsq~Z,Tt#F:prostaglandin-E synthase activitysq~ZxTtF:Tat protein bindingsq~ZTtF:S100 alpha bindingsq~ZxTt"F:receptor tyrosine kinase bindingsq~ZTt#F:calcium-dependent protein bindingsq~ZgTtF:beta-tubulin bindingsq~ZNETtF:heme bindingsq~ZvTtF:L-xylulose reductase activitysq~Z>Tt*F:low-density lipoprotein receptor bindingsq~ZTt F:FAD bindingsq~ZTtF:androgen receptor bindingsq~ZMTtF:phosphatase bindingsq~ZxTtF:GTP-dependent protein bindingsq~ZuTtF:ADP reductase activitysq~ZJTt"F:ADP-sugar diphosphatase activitysq~ZKTtF:nucleoside kinase activitysq~ZwTtF:caspase activitysq~ZʧTtF:Hsp90 protein bindingsq~ZsTtF:NF-kappaB bindingsq~Z~TtF:MutLalpha complex bindingsq~Z|Tt*F:N-terminal myristoylation domain bindingsq~Z{+Tt0F:thyrotropin-releasing hormone receptor bindingsq~ZTtF:metal ion bindingsq~ZBTtF:microtubule plus-end bindingsq~ZvTt"F:thyroid hormone receptor bindingsq~ZyTt0F:RNA splicing factor activity, transesterifi...sq~Z TtF:CARD domain bindingsq~Z"Tt0F:phosphoribosylformylglycinamidine synthase ...sq~ZTtF:valine-tRNA ligase activitysq~ZTt&F:ubiquitin activating enzyme activitysq~ZTt&F:ubiquitin-specific protease activitysq~ZTt#F:uracil DNA N-glycosylase activitysq~ZTtF:enzyme inhibitor activitysq~ZTt#F:protein kinase inhibitor activitysq~ZTt(F:protein phosphatase inhibitor activitysq~Z-Tt0F:interleukin-1, Type I, activating receptor ...sq~ZTtF:tyrosine-tRNA ligase activitysq~ZTt F:threonine-tRNA ligase activitysq~ZTt!F:methionine-tRNA ligase activitysq~Z#Tt0F:phosphoribosylaminoimidazolecarboxamide for...sq~ZVTt0F:eukaryotic translation initiation factor 2a...sq~Z\Tt$F:atypical protein kinase C activitysq~ZoTt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~Z{Tt*F:purine-nucleoside phosphorylase activitysq~ZTtF:transaldolase activitysq~ZTtF:glycine-tRNA ligase activitysq~ZTt F:histidine-tRNA ligase activitysq~ZTtF:transferrin receptor activitysq~ZTt.F:insulin-like growth factor receptor activitysq~ZTt.F:delayed rectifier potassium channel activitysq~Z Tt&F:calcium-transporting ATPase activitysq~ZpTt F:bindingsq~ZxTtF:steroid bindingsq~ZTtF:fatty acid bindingsq~ZTtF:copper ion bindingsq~ZTtF:collagen bindingsq~ZTtF:hyaluronic acid bindingsq~Z:TtF:integrin bindingsq~Z,Tt(F:tumor necrosis factor receptor bindingsq~Z!Tt F:interleukin-8 receptor bindingsq~ZTt%F:receptor signaling protein activitysq~ZTtF:SH3/SH2 adaptor activitysq~ZTt!F:small GTPase regulator activitysq~ZTt%F:GDP-dissociation inhibitor activitysq~ZTt)F:Rab GDP-dissociation inhibitor activitysq~ZTtF:Ran GTPase activator activitysq~ZTtF:receptor bindingsq~ZTtF:cytokine activitysq~ZTt/F:phosphatidylinositol-4,5-bisphosphate bindingsq~Z1TtF:tRNA bindingsq~Z Tt F:6-phosphofructokinase activitysq~Z+TtF:CTP synthase activitysq~Z;Tt&F:DNA-directed RNA polymerase activitysq~ZBTt0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~ZaTtF:IMP cyclohydrolase activitysq~ZnTt&F:NAD+ ADP-ribosyltransferase activitysq~ZTt)F:acetyl-CoA C-acetyltransferase activitysq~ZTt,F:adenine phosphoribosyltransferase activitysq~ZTtF:antigen bindingsq~ZTtF:microtubule motor activitysq~ZTt&F:protein disulfide isomerase activitysq~Z^TtF:DNA helicase activitysq~ZdTtF:damaged DNA bindingsq~ZxTt0F:specific RNA polymerase II transcription fa...sq~ZyTt0F:RNA polymerase II transcription factor acti...sq~ZTt!F:transcription cofactor activitysq~ZTtF:telomerase activitysq~ZTt(F:translation elongation factor activitysq~ZTt.F:peptidyl-prolyl cis-trans isomerase activitysq~ZTt!F:adenosylhomocysteinase activitysq~ZTtF:adenylate kinase activitysq~ZkTt"F:L-lactate dehydrogenase activitysq~Z}Tt0F:methenyltetrahydrofolate cyclohydrolase act...sq~Z~Tt)F:methionine adenosyltransferase activitysq~ZTt0F:methylenetetrahydrofolate dehydrogenase act...sq~ZTt F:endodeoxyribonuclease activitysq~ZTtF:ribonuclease H activitysq~ZTtF:phosphodiesterase I activitysq~ZTt*F:ornithine-oxo-acid transaminase activitysq~ZFTt0F:hypoxanthine phosphoribosyltransferase acti...sq~Z!TtF:guanylate kinase activitysq~Z Tt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZTtF:aldehyde reductase activitysq~ZTt%F:carbonyl reductase (NADPH) activitysq~Z Tt F:citrate (Si)-synthase activitysq~ZQTtF:aminopeptidase activitysq~ZeTt&F:cysteine-type endopeptidase activitysq~ZTt F:prolyl oligopeptidase activitysq~ZTt*F:formate-tetrahydrofolate ligase activitysq~ZTt"F:glutamate dehydrogenase activitysq~ZTt0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~Z:Tt+F:protein disulfide oxidoreductase activitysq~Z!.Tt F:translation activator activitysq~Z;Tt/F:mevalonate transmembrane transporter activitysq~Z!TtF:caspase activator activitysq~Z mTtF:DNA bending activitysq~Z# Tt'F:phosphohistidine phosphatase activitysq~Z:Tt&F:protein phosphatase type 2C activitysq~ZTt"F:phospholipase inhibitor activitysq~Z!!TtF:sphinganine kinase activitysq~Z<}TtF:cholesterol bindingsq~Z!&Tt0F:diphosphoinositol-polyphosphate diphosphata...sq~Z@GTt0F:RNA polymerase II transcription mediator ac...sq~ZTtF:N-methyltransferase activitysq~ZTt*F:3-hydroxyacyl-CoA dehydrogenase activitysq~ZTt'F:nuclear localization sequence bindingsq~Z TtF:MP kinase activitysq~ZTtF:carboxylesterase activitysq~Z Tt.F:3'(2'),5'-bisphosphate nucleotidase activitysq~Z?PTt F:AMP bindingsq~Z:Tt#F:disulfide oxidoreductase activitysq~Z4Tt C:nucleussq~Zi.Tt C:cytoplasmsq~ZTt&C:proteasome complex (sensu Eukaryota)sq~ZTtC:integral to plasma membranesq~ZTtC:endoplasmic reticulumsq~Z Tt C:cytosolsq~Zk TtC:mitochondrionsq~Z TtC:soluble fractionsq~Z TtC:intracellularsq~ZbTt C:nucleolussq~ZTt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZTtC:plasma membranesq~Z'TtC:cell surfacesq~Z>Tt C:membranesq~ZTt0C:proteasome regulatory particle (sensu Eukar...sq~ZWTt!C:perinuclear region of cytoplasmsq~ZTtC:cytoskeletonsq~ZTt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Z>TtC:integral to membranesq~ZTtC:mitochondrial matrixsq~Z TtC:nuclear poresq~ZTtC:endoplasmic reticulum lumensq~ZTt0C:eukaryotic translation initiation factor 3 ...sq~ZTt C:microtubulesq~ZTtC:membrane fractionsq~Z= TtC:actin cytoskeletonsq~ZTtC:Arp2/3 protein complexsq~ZTt%C:protein phosphatase type 2A complexsq~ZTt C:endosomesq~ZTtC:extracellular regionsq~ZTtC:ubiquitin ligase complexsq~ZTtC:extracellular spacesq~ZTt C:endoplasmic reticulum membranesq~Z?Tt0C:eukaryotic translation initiation factor 4F...sq~Z bTt!C:F-actin capping protein complexsq~ZzTtC:UBC13-MMS2 complexsq~ZTt(C:NuA4 histone acetyltransferase complexsq~ZTtC:rufflesq~ZTt C:polysomesq~ZTt C:microsomesq~Z=TtC:microtubule cytoskeletonsq~ZTt#C:ER-Golgi intermediate compartmentsq~Z>Tt$C:cytoplasmic membrane-bound vesiclesq~ZwBTt0C:heterogeneous nuclear ribonucleoprotein com...sq~ZTt C:centrosomesq~ZyTt0C:mitochondrial proton-transporting ATP synth...sq~ZTt+C:proteasome core complex (sensu Eukaryota)sq~ZTtC:stress fibersq~ZmTtC:mitochondrial outer membranesq~ZTt C:kinetochoresq~Z@TtC:sarcoplasmic reticulumsq~ZwTtC:mediator complexsq~ZTtC:Golgi membranesq~Z#TtC:transcription factor complexsq~ZTtC:condensed nuclear chromosomesq~ZMTtC:extrinsic to membranesq~ZTtC:condensed chromosomesq~ZTtC:nuclear chromosomesq~ZTt C:chromatinsq~Z TtC:chromosome, telomeric regionsq~Z@TtC:caveolar membranesq~ZTt"C:DNA replication factor C complexsq~Z;Tt C:MCM complexsq~ZoTtC:mitochondrial inner membranesq~ZyTt#C:cortical microtubule cytoskeletonsq~Z~Tt#C:mitochondrial intermembrane spacesq~ZTt'C:mitochondrial large ribosomal subunitsq~ZxTtC:cortical cytoskeletonsq~ZTt C:lysosomesq~ZTtC:late endosomesq~ZATtC:telomerase holoenzyme complexsq~Z1Tt C:spliceosomesq~ZTt&C:alpha DNA polymerase:primase complexsq~Z~Tt C:CBM complexsq~ZTt C:nucleoplasmsq~ZTtC:nuclear envelopesq~ZuTtC:T cell receptor complexsq~ZTtC:insoluble fractionsq~ZTtC:paraspecklessq~Z.TtC:chromatin assembly complexsq~ZwATtC:ribonucleoprotein complexsq~ZTtC:protein complexsq~ZdTt+C:small nucleolar ribonucleoprotein complexsq~ZTtC:actin filamentsq~ZuTt'C:trans-Golgi network transport vesiclesq~ZuTt.C:clathrin coat of trans-Golgi network vesiclesq~ZuTtC:COPI vesicle coatsq~ZuTtC:AP-2 adaptor complexsq~ZTt C:microvillussq~Z9TtC:6-phosphofructokinase complexsq~ZTt)C:voltage-gated potassium channel complexsq~ZuTt C:filopodiumsq~ZuTt,C:integral to endoplasmic reticulum membranesq~ZTtC:Golgi apparatussq~ZTtC:trans-Golgi networksq~ZATt C:lipid raftsq~Z Tt C:interleukin-1 receptor complexsq~ZTt C:ribosomesq~Z@UTt/C:proton-transporting two-sector ATPase complexsq~ZTt0C:eukaryotic translation elongation factor 1 ...sq~ZTtC:cytoplasmic dynein complexsq~ZRTtC:pore complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~ uq~ sq~Tt)P:activation of NF-kappaB-inducing kinaset7250sq~Tt0P:positive regulation of I-kappaB kinase/NF-k...t43123sq~Tt*P:positive regulation of T cell activationt50870sq~Tt0P:positive regulation of T cell cytokine prod...t2726sq~TtP:protein polyubiquitinationt209sq~Tt#P:T cell receptor signaling pathwayt50852sq~TtF:protein bindingt5515sq~TtF:signal transducer activityt4871sq~Tt#F:ubiquitin-protein ligase activityt4842pxsq~uq~ sq~Tt IPR002083tMATHsq~Tt IPR012227tTNF_recpt_TRAFsq~Tt IPR013322t TRAF-typesq~Tt IPR001841tZnf_RINGsq~Tt IPR001293tZnf_TRAFpppppxsq~uq~ sq~TtMATHtPF00917sq~Ttzf-C3HC4tPF00097sq~Ttzf-TRAFtPF02176pppppppxtQ9Y4K3t TRAF6_HUMANsq~uq~ sq~TtInterleukin-1 signal transducersq~TtRING finger protein 85ppppppppxt Homo sapienstAAKB1sq~P?{^cP%t.5'-AMP-activated protein kinase subunit beta-1sq~uq~ sq~UPtENSG00000111725pppppppppxsq~uq~ sq~mPtPRKAB1sq~mPtAMPKppppppppxsq~;uq~ @sq~ZPtP:signal transductionsq~Z Pt P:translationsq~Z9PtP:protein foldingsq~ZtPtP:DNA replicationsq~ZJPt.P:regulation of progression through cell cyclesq~Z [PtP:cell proliferationsq~ZoPt/P:ubiquitin-dependent protein catabolic processsq~ZlPt P:proteolysissq~ZPtP:lipid metabolic processsq~Z.Pt(P:regulation of translational initiationsq~ZDPt$P:protein amino acid phosphorylationsq~Z@PtP:protein modification processsq~ZOPt0P:regulation of cyclin-dependent protein kina...sq~Z PtP:RNA splicingsq~Z9Pt"P:positive regulation of apoptosissq~ZPt!P:intracellular protein transportsq~ZPtP:protein targetingsq~ZJPtP:response to unfolded proteinsq~ZPt P:glycolysissq~Z>Pt P:cell growthsq~ZsPt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZPtP:DNA recombinationsq~ZPt P:DNA repairsq~ZPt P:endocytosissq~ZIPt!P:actin filament bundle formationsq~ZPtP:cell motilitysq~ZPtP:protein import into nucleussq~ZPt P:chemotaxissq~Z*PtP:inflammatory responsesq~Z>Pt!P:response to DNA damage stimulussq~ZhPtP:cytoskeletal anchoringsq~ZPtP:anti-apoptosissq~ZPtP:nucleocytoplasmic transportsq~ZPtP:mitochondrial transportsq~Z#[Pt+P:pentose-phosphate shunt, oxidative branchsq~ZPtP:dicarboxylic acid transportsq~ZPt0P:retrograde vesicle-mediated transport, Golg...sq~ZPt(P:intra-Golgi vesicle-mediated transportsq~ZPtP:ion transportsq~Z'Pt"P:cholesterol biosynthetic processsq~ZPtP:fatty acid beta-oxidationsq~ZnPtP:ATP-dependent proteolysissq~ZPt/P:transcription from RNA polymerase II promotersq~ZGPt%P:protein amino acid ADP-ribosylationsq~ZPtP:nucleotide-excision repairsq~Z=PtP:protein complex assemblysq~ZaPtP:CTP biosynthetic processsq~ZEPt)P:pyrimidine nucleoside metabolic processsq~Z8PtP:ATP catabolic processsq~ZPtP:purine ribonucleoside salvagesq~ZPt(P:purine nucleotide biosynthetic processsq~ZPt0P:mitochondrial electron transport, NADH to u...sq~ZPtP:electron transportsq~ZPtP:fumarate metabolic processsq~ZPtP:citrate metabolic processsq~ZPtP:postreplication repairsq~ZPt$P:DNA fragmentation during apoptosissq~ZPtP:visual perceptionsq~Z#PtP:threonyl-tRNA aminoacylationsq~ZPtP:regulation of translationsq~Z PtP:translational initiationsq~ZPtP:tRNA modificationsq~ZPtP:mRNA processingsq~ZPtP:RNA processingsq~ZPtP:mRNA polyadenylationsq~ZPt0P:regulation of transcription from RNA polyme...sq~ZPtP:nucleosome disassemblysq~ZPtP:nucleosome assemblysq~ZPt0P:tricarboxylic acid cycle intermediate metab...sq~ZYPtP:protein homotetramerizationsq~ZPtP:cellular respirationsq~ZPt0P:positive regulation of gene-specific transc...sq~Z:Pt"P:negative regulation of apoptosissq~ZPt%P:regulation of macrophage activationsq~ZPtP:response to drugsq~ZUPtP:regulation of phosphorylationsq~ZPt)P:retrograde transport, endosome to Golgisq~Z*PtP:protein refoldingsq~ZPt,P:negative regulation of histone acetylationsq~ZyRPt-P:positive regulation of histone modificationsq~ZuPtP:neuron differentiationsq~ZuPt*P:protein import into mitochondrial matrixsq~ZuPt0P:positive regulation of nitric oxide biosynt...sq~ZPtP:regulation of transcriptionsq~ZPt0P:positive regulation of cholesterol biosynth...sq~ZǔPt.P:activation of NF-kappaB transcription factorsq~ZƤPt#P:T cell receptor signaling pathwaysq~ZiPtP:synaptic vesicle transportsq~ZPtP:mRNA stabilizationsq~ZPt%P:vesicle transport along microtubulesq~ZPt0P:negative regulation of glucosylceramide bio...sq~ZPt P:hypoxanthine metabolic processsq~ZPt0P:positive regulation of dopamine metabolic p...sq~ZDPt0P:negative regulation of transcription, DNA-d...sq~ZPt'P:positive regulation of anti-apoptosissq~ZPt#P:positive regulation of DNA repairsq~Z`Pt&P:regulation of neuron differentiationsq~ZKgPtP:D-ribose catabolic processsq~ZKPt0P:cytokine and chemokine mediated signaling p...sq~Z@PtP:histone ubiquitinationsq~ZPt0P:regulation of actin polymerization and/or d...sq~ZOPt P:circulationsq~ZPt P:behaviorsq~ZPtP:blood coagulationsq~Z]PtP:muscle developmentsq~ZPtP:brain developmentsq~ZsPtP:spermatogenesissq~ZkPt&P:multicellular organismal developmentsq~ZKPtP:protein kinase cascadesq~ZPtP:signal complex assemblysq~ZPt0P:cell surface receptor linked signal transdu...sq~ZPtP:regulation of mitosissq~Z Pt P:histone mRNA metabolic processsq~Z!`PtP:epidermis developmentsq~Z!PtP:male gonad developmentsq~Z@aPt&P:negative regulation of transcriptionsq~Z?JPt+P:regulation of striated muscle developmentsq~Z?@PtP:vesicle-mediated transportsq~Z>xPtP:proton transportsq~Z>@PtP:coenzyme A metabolic processsq~Z&PtP:organ morphogenesissq~Z%PtP:response to virussq~Z$ZPtP:protein secretionsq~Z$Pt0P:pyrimidine ribonucleotide biosynthetic processsq~Z#Pt.P:ribonucleoside diphosphate catabolic processsq~Z#Pt"P:purine base biosynthetic processsq~Z!Pt%P:caspase activation via cytochrome csq~ZPtP:cell cycle arrestsq~ZPtP:gluconeogenesissq~Z-Pt&P:epithelial to mesenchymal transitionsq~ZPt0P:positive regulation of ubiquitin ligase act...sq~ZPtP:response to hypoxiasq~ZPt$P:prostaglandin biosynthetic processsq~ZPt$P:DNA double-strand break processingsq~ZPt)P:nuclear mRNA 3'-splice site recognitionsq~ZhPt0P:cis assembly of U2-type pre-catalytic splic...sq~ZPt$P:assembly of spliceosomal tri-snRNPsq~ZPtP:activation of MAPK activitysq~ZPt0P:mRNA catabolic process, nonsense-mediated d...sq~ZVPt'P:G2/M transition of mitotic cell cyclesq~ZRPt'P:G1/S transition of mitotic cell cyclesq~ZRPtF:protein bindingsq~ZPt F:RNA bindingsq~ZPt F:ATP bindingsq~ZPt$F:structural constituent of ribosomesq~ZTPtF:GTPase activitysq~ZPtF:actin bindingsq~ZNJPtF:unfolded protein bindingsq~ZMPtF:enzyme bindingsq~ZPt0F:translation factor activity, nucleic acid b...sq~ZtPtF:transcription factor activitysq~ZPt(F:translation initiation factor activitysq~ZPtF:calcium ion bindingsq~ZPt%F:ATP-dependent RNA helicase activitysq~ZiPt"F:protein-tyrosine kinase activitysq~ZAPtF:ATPase activitysq~ZPtF:histone bindingsq~ZPtF:enoyl-CoA hydratase activitysq~ZQPtF:microtubule bindingsq~Z]Pt F:DNA bindingsq~ZPt#F:ubiquitin-protein ligase activitysq~Z3Pt#F:protein homodimerization activitysq~Z2PtF:identical protein bindingsq~ZPt$F:transcription corepressor activitysq~ZSPt(F:cAMP-dependent protein kinase activitysq~ZPt)F:acetyl-CoA C-acetyltransferase activitysq~ZPt%F:ATP-dependent DNA helicase activitysq~Z+PtF:CTP synthase activitysq~ZnPt&F:NAD+ ADP-ribosyltransferase activitysq~Z:Pt(F:ion transmembrane transporter activitysq~Z&PtF:ATP citrate synthase activitysq~ZPt%F:carbonyl reductase (NADPH) activitysq~Z!XPtF:Ran GTPase bindingsq~ZPt$F:serine-type endopeptidase activitysq~Z!uPtF:protein transporter activitysq~Z!Pt(F:ubiquitin-specific protease 5 activitysq~ZePt&F:cysteine-type endopeptidase activitysq~ZQPtF:aminopeptidase activitysq~ZOPtF:endopeptidase activitysq~Z#_PtF:electron carrier activitysq~Z!Pt0F:protein phosphatase type 2A regulator activitysq~Z%Pt&F:glycogen debranching enzyme activitysq~Z Pt"F:cytochrome-b5 reductase activitysq~Z!.Pt F:translation activator activitysq~Z Pt F:6-phosphofructokinase activitysq~ZPtF:mRNA bindingsq~ZQPtF:GMP synthase activitysq~ZPt0F:ATPase activity, coupled to transmembrane m...sq~Z8Pt#F:neuronal Cdc2-like kinase bindingsq~ZPt$F:transcription coactivator activitysq~ZdPtF:damaged DNA bindingsq~ZPtF:magnesium ion bindingsq~ZzPtF:ubiquitin bindingsq~ZePtF:protein self-associationsq~ZcPt0F:electron transporter, transferring electron...sq~ZGPtF:actin filament bindingsq~ZuPtF:ADP reductase activitysq~ZPt%F:translation release factor activitysq~ZxPtF:TPR domain bindingsq~Z@Pt"F:transcription activator activitysq~ZPt*F:3-hydroxyacyl-CoA dehydrogenase activitysq~ZPtF:SH2 domain bindingsq~ZBPt"F:fibroblast growth factor bindingsq~ZJPt"F:ADP-sugar diphosphatase activitysq~ZPt F:coagulation factor Xa activitysq~ZMPtF:chemokine bindingsq~ZNEPtF:heme bindingsq~ZPtF:microtubule motor activitysq~ZPt&F:protein disulfide isomerase activitysq~ZvPt*F:nitric-oxide synthase regulator activitysq~ZwPtF:protein binding, bridgingsq~Z1PtF:tRNA bindingsq~Z!PtF:pyridoxal kinase activitysq~ZPtF:fatty acid bindingsq~ZPt F:threonine-tRNA ligase activitysq~ZPtF:uridine kinase activitysq~ZPtF:signal transducer activitysq~ZPtF:SH3/SH2 adaptor activitysq~ZPt/F:phosphatidylinositol-4,5-bisphosphate bindingsq~ZPt F:GTP bindingsq~ZPt)F:Rab GDP-dissociation inhibitor activitysq~ZPtF:Ran GTPase activator activitysq~ZPtF:receptor bindingsq~ZPtF:cytokine activitysq~ZNPtF:structural molecule activitysq~ZPPt(F:structural constituent of cytoskeletonsq~Z_PtF:transporter activitysq~ZPt0F:dicarboxylic acid transmembrane transporter...sq~ZPt!F:methionine-tRNA ligase activitysq~ZkPt"F:L-lactate dehydrogenase activitysq~ZZPt!F:ATP-dependent helicase activitysq~ZPtF:cytoskeletal protein bindingsq~ZPt*F:NADH dehydrogenase (ubiquinone) activitysq~Z~Pt)F:methionine adenosyltransferase activitysq~ZPt(F:protein phosphatase inhibitor activitysq~ZPtF:poly(A) bindingsq~ZPtF:methyltransferase activitysq~ZPtF:fumarate hydratase activitysq~ZPt*F:ornithine-oxo-acid transaminase activitysq~ZPt F:prolyl oligopeptidase activitysq~Z@PtF:protein kinase activitysq~ZPt/F:ribonucleoside-diphosphate reductase activitysq~ZFPt0F:hypoxanthine phosphoribosyltransferase acti...sq~ZiPt C:cytoplasmsq~ZPt C:nucleussq~ZPt&C:proteasome complex (sensu Eukaryota)sq~ZPt C:cytosolsq~ZPtC:intracellularsq~ZkPtC:mitochondrionsq~ZbPt C:nucleolussq~ZPtC:endoplasmic reticulumsq~ZPtC:mitochondrial matrixsq~Z1Pt C:spliceosomesq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZPtC:cytoskeletonsq~ZPtC:extracellular regionsq~ZWPt!C:perinuclear region of cytoplasmsq~ZPtC:soluble fractionsq~ZyPt0C:mitochondrial proton-transporting ATP synth...sq~Z= PtC:actin cytoskeletonsq~Z PtC:nuclear poresq~ZwAPtC:ribonucleoprotein complexsq~ZPt0C:eukaryotic translation initiation factor 3 ...sq~Z>Pt C:membranesq~ZPtC:plasma membranesq~ZPt C:lysosomesq~ZPtC:hemoglobin complexsq~ZPtC:stress fibersq~ZPt0C:proteasome regulatory particle (sensu Eukar...sq~Z bPt!C:F-actin capping protein complexsq~ZPtC:rufflesq~ZPtC:postsynaptic membranesq~Z$PtC:citrate lyase complexsq~ZPt C:chromatinsq~ZPt+C:proteasome core complex (sensu Eukaryota)sq~ZSPt.C:ribonucleoside-diphosphate reductase complexsq~Z9PtC:6-phosphofructokinase complexsq~Z2Pt C:cell cortexsq~ZPt C:microvillussq~ZPtC:actin filamentsq~ZPtC:ubiquitin ligase complexsq~ZPt%C:protein phosphatase type 2A complexsq~ZPtC:kinesin complexsq~ZPt0C:eukaryotic translation elongation factor 1 ...sq~ZPt#C:ER-Golgi intermediate compartmentsq~ZPt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Z}PtC:cleavage furrowsq~ZPt C:endoplasmic reticulum membranesq~ZPtC:endoplasmic reticulum lumensq~ZPt0C:signal recognition particle, endoplasmic re...sq~ZzPtC:UBC13-MMS2 complexsq~Z>PtC:integral to membranesq~ZPtC:membrane fractionsq~ZwBPt0C:heterogeneous nuclear ribonucleoprotein com...sq~Zw Pt C:midbodysq~Z?PtC:prefoldin complexsq~Z?Pt0C:eukaryotic translation initiation factor 4F...sq~ZuPtC:COPI vesicle coatsq~ZuPtC:clathrin coatsq~Z@KPtC:myosin complexsq~ZPt C:endosomesq~Z{PtC:PcG protein complexsq~ZPtC:nuclear envelopesq~ZPtC:translocon complexsq~Z'PtC:cell surfacesq~ZPtC:late endosomesq~ZPtC:isoamylase complexsq~ZPt'C:mitochondrial small ribosomal subunitsq~Z~Pt#C:mitochondrial intermembrane spacesq~Z;Pt C:MCM complexsq~ZsPt+C:mitochondrial respiratory chain complex Isq~ZxPtC:cortical cytoskeletonsq~Z2Pt C:snRNP U5sq~ZPt(C:NuA4 histone acetyltransferase complexsq~ZMPtC:extrinsic to membranepppppxsq~uq~ sq~PtP:signal transductiont7165sq~PtF:protein bindingt5515ppppppppxsq~uq~ sq~Pt IPR006828tAMPKBIsq~Pt IPR004193tGlyco_hydro_13_Nppppppppxsq~uq~ sq~PtAMPKBItPF04739sq~Pt Isoamylase_NtPF02922ppppppppxtQ9Y478t AAKB1_HUMANsq~uq~ sq~PtAMPK beta-1 chainsq~PtAMPKbppppppppxt Homo sapienstRA54Bsq~P?88Kh%t+DNA repair and recombination protein RAD54Bsq~uq~ sq~UKhtENSG00000197275pppppppppxsq~uq~ sq~mKhtRAD54Bpppppppppxsq~/uq~ Psq~ZoKht/P:ubiquitin-dependent protein catabolic processsq~ZDKht$P:protein amino acid phosphorylationsq~ZKhtP:meiotic recombinationsq~Z|Kht"P:DNA unwinding during replicationsq~ZKht P:DNA repairsq~ZKhtP:mitotic recombinationsq~Z@KhtP:protein modification processsq~ZpKhtP:ubiquitin cyclesq~ZKht%P:mitotic metaphase plate congressionsq~ZKht!P:regulation of exit from mitosissq~ZKhtP:signal transductionsq~ZsKhtP:spermatogenesissq~Z|KhtP:female gamete generationsq~Z<KhtP:protein homooligomerizationsq~ZuwKht0P:regulation of mitotic metaphase/anaphase tr...sq~ZKht0P:positive regulation of glycogen biosyntheti...sq~ZǢKht%P:positive regulation of DNA ligationsq~ZPKht P:G1 phase of mitotic cell cyclesq~ZKht0P:DNA damage response, signal transduction by...sq~ZKht0P:double-strand break repair via homologous r...sq~ZKhtF:protein bindingsq~ZKht F:ATP bindingsq~Z]Kht F:DNA bindingsq~ZMKKht+F:small conjugating protein ligase activitysq~ZKhtF:magnesium ion bindingsq~ZuKhtF:manganese ion bindingsq~ZKht F:RNA bindingsq~Z2KhtF:identical protein bindingsq~ZKht/F:single-stranded DNA-dependent ATPase activitysq~ZKhtF:recombinase activitysq~ZjKhtF:double-stranded DNA bindingsq~ZqKhtF:single-stranded DNA bindingsq~ZpKht F:bindingsq~ZKht#F:ubiquitin-protein ligase activitysq~ZiKht"F:protein-tyrosine kinase activitysq~ZIKhtF:casein kinase I activitysq~ZVKhtF:protein C-terminus bindingsq~ZBKht*F:protein serine/threonine kinase activitysq~ZiKht C:cytoplasmsq~ZKhtC:condensed nuclear chromosomesq~ZKht C:nucleussq~ZKhtC:synaptonemal complexsq~ZKhtC:cytoskeletonsq~ZKht C:polysomesq~Z@Kht C:PML bodysq~Z0KhtC:anaphase-promoting complexsq~ZKht&C:proteasome complex (sensu Eukaryota)pppppppppppppppppppppppppppppppppxsq~uq~ sq~KhtP:meiotic recombinationt7131sq~KhtP:mitotic recombinationt6312sq~KhtF:DNA helicase activityt3678sq~KhtF:RNA helicase activityt3724ppppppxsq~uq~ sq~Kht IPR014001t DEAD-like_Nsq~Kht IPR001650tDNA/RNA_helicase_Csq~Kht IPR014021tHelicase_SF1/SF2_ATP-bdsq~Kht IPR000330tSNF2_Nppppppxsq~uq~ sq~Kht Helicase_CtPF00271sq~KhtSNF2_NtPF00176ppppppppxtQ9Y620t RA54B_HUMANsq~uq~ sq~KhtRAD54 homolog Bpppppppppxt Homo sapienstGBRL2sq~P?hx4':D:%t:Gamma-aminobutyric acid receptor-associated protein-like 2sq~uq~ sq~UDtENSG00000034713pppppppppxsq~uq~ sq~mDt GABARAPL2sq~mDtFLC3Asq~mDtGEF2pppppppxsq~uq~ @sq~ZDtP:signal transductionsq~Z Dt P:translationsq~ZlDt P:proteolysissq~ZDtP:protein targeting to membranesq~ZtDtP:DNA replicationsq~Z-DtP:autophagic vacuole formationsq~ZhDtP:cytoskeletal anchoringsq~Z>Dt!P:response to DNA damage stimulussq~ZDt P:cell cyclesq~Z&DtP:response to stresssq~Z DtP:membrane fusionsq~ZDt-P:mitotic spindle organization and biogenesissq~ZjDtP:microtubule-based movementsq~ZKDtP:protein kinase cascadesq~Z@aDt&P:negative regulation of transcriptionsq~Z?EDtP:endosome transportsq~Z>DtP:viral reproductionsq~Z=7DtP:oxygen transportsq~Z$DtP:response to UVsq~Z!DtP:apoptotic programsq~Z DtP:RNA splicingsq~Z [DtP:cell proliferationsq~ZDt P:behaviorsq~ZDtP:caspase activationsq~ZDtP:induction of apoptosissq~ZDt P:apoptosissq~ZDt(P:intra-Golgi vesicle-mediated transportsq~ZDtP:anion transportsq~ZDtP:fatty acid beta-oxidationsq~ZDtP:protein targeting to vacuolesq~ZDt+P:NLS-bearing substrate import into nucleussq~ZoDt/P:ubiquitin-dependent protein catabolic processsq~ZaDtP:protein amino acid lipidationsq~ZODt P:protein amino acid methylationsq~ZDt P:autophagysq~Z9DtP:protein foldingsq~Z.Dt(P:regulation of translational initiationsq~Z%DtP:tyrosyl-tRNA aminoacylationsq~ZDtP:mRNA processingsq~ZDt,P:regulation of transcription, DNA-dependentsq~ZDtP:purine ribonucleoside salvagesq~ZDt(P:purine nucleotide biosynthetic processsq~ZDt P:glycolysissq~ZDt P:endocytosissq~Z@DtP:protein ubiquitinationsq~ZGgDt0P:protein amino acid N-linked glycosylation v...sq~ZRDt'P:G1/S transition of mitotic cell cyclesq~ZDt P:hypoxanthine metabolic processsq~ZuDtP:protein repairsq~ZDt0P:positive regulation of dopamine metabolic p...sq~ZzDt-P:positive regulation of protein modificationsq~ZDt)P:retrograde transport, endosome to Golgisq~ZxDt0P:positive regulation of transcription from R...sq~ZUDtP:regulation of phosphorylationsq~ZDDt$P:protein amino acid phosphorylationsq~ZDtP:histone exchangesq~Z DtP:blastocyst developmentsq~ZDtP:protein localizationsq~ZGDt0P:peptidyl-proline hydroxylation to 4-hydroxy...sq~ZTDtP:S phase of mitotic cell cyclesq~ZDt0P:mRNA catabolic process, nonsense-mediated d...sq~ZDt!P:DNA synthesis during DNA repairsq~ZYDtP:protein homotetramerizationsq~ZIDt!P:actin filament bundle formationsq~ZDtP:skeletal developmentsq~ZDt+P:mitochondrion transport along microtubulesq~ZrDt0P:regulation of I-kappaB kinase/NF-kappaB cas...sq~ZDtF:protein bindingsq~ZDt$F:structural constituent of ribosomesq~ZDt F:RNA bindingsq~Z]Dt F:DNA bindingsq~ZTDtF:GTPase activitysq~Z *Dt"F:cysteine-type peptidase activitysq~ZQDtF:microtubule bindingsq~Z DtF:vitamin D3 receptor activitysq~ZgDtF:beta-tubulin bindingsq~ZGDtF:actin filament bindingsq~Z3Dt#F:protein homodimerization activitysq~Z!Dt0F:protein phosphatase type 2A regulator activitysq~ZMDtF:protein kinase bindingsq~Z!DtF:caspase activator activitysq~ZʧDtF:Hsp90 protein bindingsq~ZMDtF:enzyme bindingsq~ZNEDtF:heme bindingsq~Z!Dt+F:small protein conjugating enzyme activitysq~ZzDtF:ubiquitin bindingsq~Z2DtF:identical protein bindingsq~ZDtF:ATPase activity, coupledsq~ZeDtF:protein self-associationsq~ZDtF:SH2 domain bindingsq~ZyDt0F:RNA splicing factor activity, transesterifi...sq~ZxDt"F:receptor tyrosine kinase bindingsq~ZwDtF:protein binding, bridgingsq~ZY<Dt&F:voltage-gated anion channel activitysq~ZMqDtF:oxygen bindingsq~ZDt&F:ubiquitin activating enzyme activitysq~Z Dt F:6-phosphofructokinase activitysq~Z3DtF:delta DNA polymerase activitysq~ZDt%F:carbonyl reductase (NADPH) activitysq~ZDtF:enoyl-CoA hydratase activitysq~ZFDt0F:hypoxanthine phosphoribosyltransferase acti...sq~ZDt"F:phospholipase inhibitor activitysq~Z0Dt,F:procollagen-proline 4-dioxygenase activitysq~ZBDt*F:protein serine/threonine kinase activitysq~ZoDt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~ZDtF:transketolase activitysq~ZDtF:iron ion bindingsq~ZDtF:tyrosine-tRNA ligase activitysq~ZDtF:oxygen transporter activitysq~Z!Dt F:interleukin-8 receptor bindingsq~ZDtF:Ran GTPase activator activitysq~ZDtF:signal transducer activitysq~ZDtF:microtubule motor activitysq~ZNDtF:structural molecule activitysq~ZbDtF:chromatin bindingsq~ZDtF:magnesium ion bindingsq~ZDt&F:protein disulfide isomerase activitysq~ZtDtF:transcription factor activitysq~ZDt%F:translation release factor activitysq~ZDt(F:translation initiation factor activitysq~ZiDt C:cytoplasmsq~ZDt C:cytosolsq~ZkDtC:mitochondrionsq~ZDt C:nucleussq~ZDtC:soluble fractionsq~ZDt&C:proteasome complex (sensu Eukaryota)sq~ZDtC:cytoskeletonsq~ZDtC:intracellularsq~ZDt C:ribosomesq~ZDt C:microtubule associated complexsq~ZDtC:endoplasmic reticulumsq~ZDt&C:cytoplasmic ubiquitin ligase complexsq~ZDt C:chromatinsq~ZWDt!C:perinuclear region of cytoplasmsq~ZDtC:rufflesq~ZDtC:condensed nuclear chromosomesq~Z;Dt C:MCM complexsq~ZRDtC:pore complexsq~ZDt C:polysomesq~ZxDt&C:rough endoplasmic reticulum membranesq~ZxDtC:cortical cytoskeletonsq~Z :Dt$C:oligosaccharyl transferase complexsq~ZDt#C:ER-Golgi intermediate compartmentsq~ZDtC:hemoglobin complexsq~ZDt0C:proteasome regulatory particle (sensu Eukar...sq~ZDt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZDtC:cytoplasmic dynein complexsq~ZDtC:actin filamentsq~ZDtC:plasma membranesq~ZDtC:integral to plasma membranesq~ZDt C:microvillussq~Z)DtC:ciliumsq~ZDtC:late endosomesq~ZDt C:endosomesq~Z DtC:nuclear poresq~ZMDtC:extrinsic to membranesq~ZDtC:extracellular regionsq~ZDtC:extracellular spacesq~ZDtC:membrane fractionsq~Z?Dt0C:eukaryotic translation initiation factor 4F...sq~Z>DtC:integral to membranesq~Z'DtC:cell surfacesq~ZbDt C:nucleolussq~ZmDtC:mitochondrial outer membranesq~ZDt C:lysosomesq~Z9DtC:6-phosphofructokinase complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~DtF:actin bindingt3779sq~Dt F:ATP bindingt5524sq~DtF:beta-tubulin bindingt48487sq~DtF:GABA receptor bindingt50811sq~DtC:cytoskeletont5856pppppxsq~uq~ sq~Dt IPR004241tMAP1_LC3pppppppppxsq~uq~ sq~DtMAP1_LC3tPF02991pppppppppxtP60520t GBRL2_HUMANsq~uq~ sq~Dt*GABA(A) receptor-associated protein-like 2sq~DtGanglioside expression factor 2sq~DtGEF-2sq~Dt$General protein transport factor p16sq~Dt"MAP1 light chain 3-related proteinpppppxt Homo sapienstPSB10sq~P?mm%t)Proteasome subunit beta type-10 precursorsq~uq~ sq~UtENSG00000205220pppppppppxsq~uq~ sq~mtPSMB10sq~mtMECL1ppppppppxsq~ uq~ sq~Z \t+P:positive regulation of cell proliferationsq~ZtP:nervous system developmentsq~Zt0P:transmembrane receptor protein tyrosine pho...sq~ZtF:protein bindingsq~Zt F:RNA bindingsq~Zt(F:protein phosphatase inhibitor activitysq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zt C:nucleussq~ZtC:endoplasmic reticulumsq~Zt C:polysomesq~ZtC:extracellular spacesq~Zit C:cytoplasmppppppppxsq~uq~ sq~tP:humoral immune responset6959sq~t&C:proteasome complex (sensu Eukaryota)t502ppppppppxsq~uq~ sq~t IPR000243t Pept_T1A_subBsq~t IPR001353tProteasome_A_Bppppppppxsq~uq~ sq~t ProteasometPF00227pppppppppxtP40306t PSB10_HUMANsq~uq~ sq~tProteasome subunit beta-2isq~tProteasome MECl-1sq~tMacropain subunit MECl-1sq~t3Multicatalytic endopeptidase complex subunit MECl-1ppppppxt Homo sapienstWDR8sq~P?NQ^L47Q77%tWD repeat-containing protein 8sq~uq~ sq~UQ7tENSG00000116213pppppppppxsq~uq~ sq~mQ7tWDR8pppppppppxsq~uq~ sq~ZQ7tP:signal transductionsq~Z$Q7t0P:folic acid and derivative biosynthetic processsq~ZQ7t P:cell cyclesq~Z9Q7tP:protein foldingsq~ZQ7tP:sister chromatid cohesionsq~ZQ7t P:apoptosissq~ZQ7tP:caspase activationsq~ZQ7tP:smooth muscle contractionsq~Z&Q7tP:response to stresssq~Z*Q7tP:inflammatory responsesq~ZQ7t P:meiosissq~ZQ7t0P:traversing start control point of mitotic c...sq~ZQ7t P:mitosissq~ZQ7t-P:mitotic spindle organization and biogenesissq~ZQ7t!P:intracellular protein transportsq~ZQ7tP:calcium ion transportsq~ZQ7tP:lipid metabolic processsq~ZQ7tP:tricarboxylic acid cyclesq~Z~Q7tP:DNA replication initiationsq~ZQ7tP:regulation of DNA replicationsq~ZQ7tP:base-excision repairsq~ZQ7tP:mismatch repairsq~ZQ7tP:postreplication repairsq~ZQ7tP:double-strand break repairsq~ZQ7t0P:regulation of transcription from RNA polyme...sq~ZQ7tP:rRNA processingsq~ZQ7t/P:transcription from RNA polymerase II promotersq~Z Q7t P:translationsq~Z]Q7t+P:protein amino acid O-linked glycosylationsq~ZQ7t0P:mitochondrial electron transport, NADH to u...sq~ZQ7tP:nervous system developmentsq~ZxQ7tP:unfolded protein responsesq~ZxQ7t-P:retrograde protein transport, ER to cytosolsq~ZQ7t"P:regulation of cell proliferationsq~ZQ7tP:menstrual cyclesq~ZQ7t0P:positive regulation of gene-specific transc...sq~Z-Q7t&P:epithelial to mesenchymal transitionsq~Z2Q7t$P:maintenance of DNA repeat elementssq~ZQ7t+P:mitochondrion transport along microtubulesq~Z{Q7tP:elastic fiber assemblysq~ZjQ7t!P:smooth muscle fiber developmentsq~ZQ7tP:inactivation of MAPK activitysq~ZVQ7t'P:G2/M transition of mitotic cell cyclesq~ZvQ7t)P:ER-associated protein catabolic processsq~Zv!Q7t P:muscle thick filament assemblysq~ZvQ7tP:keratinocyte differentiationsq~ZQ7tP:embryo implantationsq~ZQ7tP:response to nutrientsq~Z \Q7t+P:positive regulation of cell proliferationsq~Z!`Q7tP:epidermis developmentsq~Z$NQ7tP:DNA mediated transformationsq~Z$Q7tP:response to light stimulussq~Z:Q7tP:protein transportsq~Z=Q7tP:glutamate transportsq~Z>Q7tP:mRNA metabolic processsq~ZVQ7t P:JNK cascadesq~Z@Q7tP:protein ubiquitinationsq~ZJQ7t.P:regulation of progression through cell cyclesq~ZQ7tF:protein bindingsq~ZQ7t F:ATP bindingsq~ZQ7t F:RNA bindingsq~ZQ7t*F:formate-tetrahydrofolate ligase activitysq~ZtQ7tF:transcription factor activitysq~ZNJQ7tF:unfolded protein bindingsq~Z}Q7t0F:methenyltetrahydrofolate cyclohydrolase act...sq~ZNQ7tF:structural molecule activitysq~ZpQ7t F:bindingsq~ZQ7t*F:NADH dehydrogenase (ubiquinone) activitysq~ZQ7tF:signal transducer activitysq~Z Q7t(F:acetylglucosaminyltransferase activitysq~ZQ7tF:microtubule motor activitysq~Z sQ7t"F:structural constituent of musclesq~ZQ7tF:signal sequence bindingsq~ZQ7tF:GTPase inhibitor activitysq~ZQQ7tF:microtubule bindingsq~Z#_Q7tF:electron carrier activitysq~Z}Q7t!F:guanine/thymine mispair bindingsq~ZAQ7tF:ATPase activitysq~ZQ7tF:lysozyme activitysq~ZQ7tF:motor activitysq~ZQ7t$F:structural constituent of ribosomesq~Z3Q7t#F:protein homodimerization activitysq~ZQ7t$F:transcription corepressor activitysq~ZQ7t0F:methylenetetrahydrofolate dehydrogenase act...sq~ZQ7t0F:methylenetetrahydrofolate dehydrogenase (NA...sq~ZUQ7t*F:cyclin-dependent protein kinase activitysq~ZQ7t0F:pyruvate dehydrogenase (acetyl-transferring...sq~ZBQ7t$F:nucleoside-triphosphatase activitysq~ZPQ7t(F:structural constituent of cytoskeletonsq~ZQ7t0F:L-glutamate transmembrane transporter activitysq~ZQ7t!F:methionine-tRNA ligase activitysq~Z]Q7t F:DNA bindingsq~ZgQ7tF:beta-tubulin bindingsq~ZQ7t%F:protein heterodimerization activitysq~ZQ7tF:dynein bindingsq~Z2Q7tF:identical protein bindingsq~ZqQ7tF:single-stranded DNA bindingsq~ZQ7t F:GTP bindingsq~ZQ7tF:calcium ion bindingsq~Z Q7t&F:calcium-transporting ATPase activitysq~Zi Q7t C:cytoplasmsq~ZQ7t C:nucleussq~ZQ7tC:cytoskeletonsq~ZQ7t C:cytosolsq~Z?Q7tC:prefoldin complexsq~ZbQ7t C:nucleolussq~ZQ7t&C:proteasome complex (sensu Eukaryota)sq~ZkQ7tC:mitochondrionsq~ZQ7t C:microsomesq~ZWQ7t!C:perinuclear region of cytoplasmsq~ZQ7tC:condensed nuclear chromosomesq~ZQ7tC:spindle polesq~ZQ7tC:cornified envelopesq~Z>Q7tC:integral to membranesq~ZwDQ7t)C:small nuclear ribonucleoprotein complexsq~Z~-Q7tC:MutSalpha complexsq~Z~.Q7tC:MutSbeta complexsq~Z|Q7tC:filamentous actinsq~Z@Q7tC:sarcoplasmic reticulumsq~ZoQ7tC:mitochondrial inner membranesq~ZsQ7t+C:mitochondrial respiratory chain complex Isq~ZQ7tC:mitochondrial matrixsq~ZQ7tC:endoplasmic reticulumsq~ZQ7tC:translocon complexsq~ZQ7tC:Golgi apparatussq~ZQ7t0C:proteasome regulatory particle (sensu Eukar...sq~ZQ7t0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZQ7tC:muscle myosin complexsq~ZQ7t&C:alpha DNA polymerase:primase complexsq~ZQ7tC:extracellular spacesq~ZQ7tC:basement membranesq~Z@MQ7tC:unconventional myosin complexsq~Z@KQ7tC:myosin complexsq~Z?Q7tC:nuclear matrixsq~Z?Q7tC:lateral plasma membranesq~Z&Q7tC:basal plasma membranesq~ZQ7t C:peroxisomesq~Z VQ7tC:cohesin complexsq~ZQ7t C:signalosomesq~ZQ7t0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZQ7t C:microvilluspppppppppppppppppppxsq~uq~ sq~Q7tF:protein bindingt5515pppppppppxsq~uq~ sq~Q7t IPR001680tWD40pppppppppxsq~uq~ sq~Q7tWD40tPF00400pppppppppxtQ9P2S5t WDR8_HUMANpt Homo sapienstSYACsq~P?ٙD%t#Alanyl-tRNA synthetase, cytoplasmicsq~uq~ sq~UDtENSG00000090861pppppppppxsq~uq~ sq~mDtAARSpppppppppxsq~ uq~ sq~ZuDt0P:positive regulation of nitric oxide biosynt...sq~ZDtP:signal transductionsq~ZJDtP:response to unfolded proteinsq~ZDtP:anti-apoptosissq~ZDtP:translational elongationsq~ZDtF:protein bindingsq~ZDt(F:translation elongation factor activitysq~ZDtF:transcription factor bindingsq~ZvDt*F:nitric-oxide synthase regulator activitysq~ZxDtF:TPR domain bindingsq~ZiDt C:cytoplasmsq~ZDt0C:eukaryotic translation elongation factor 1 ...sq~ZDt&C:proteasome complex (sensu Eukaryota)pppppppxsq~uq~ sq~DtP:alanyl-tRNA aminoacylationt6419sq~DtP:tRNA processingt8033sq~DtF:tRNA bindingt49sq~Dt C:cytoplasmt5737sq~DtC:soluble fractiont5625pppppxsq~uq~ sq~Dt IPR002318tAla-tRNA-synth_IIcsq~Dt IPR003156tPesterase_DHHA1sq~Dt IPR012947ttRNA_SADpppppppxsq~uq~ sq~DtDHHA1tPF02272sq~Dt tRNA-synt_2ctPF01411sq~DttRNA_SADtPF07973pppppppxtP49588t SYAC_HUMANsq~uq~ sq~DtAlanine--tRNA ligasesq~DtAlaRSsq~Dt!Renal carcinoma antigen NY-REN-42pppppppxt Homo sapienstSMAD1sq~P?=%t)Mothers against decapentaplegic homolog 1sq~uq~ sq~UtENSG00000170365pppppppppxsq~uq~ sq~mtSMAD1sq~mtBSP1sq~mtMADH1sq~mtMADR1ppppppxsq~uq~ @sq~Z t,P:regulation of transcription, DNA-dependentsq~Z tP:signal transductionsq~ZDt$P:protein amino acid phosphorylationsq~Zt/P:transcription from RNA polymerase II promotersq~ZtP:nervous system developmentsq~Zt0P:regulation of transcription from RNA polyme...sq~Z@at&P:negative regulation of transcriptionsq~Z t0P:transforming growth factor beta receptor si...sq~Z`t+P:small GTPase mediated signal transductionsq~Z ]t+P:negative regulation of cell proliferationsq~Zut&P:positive regulation of transcriptionsq~ZJt.P:regulation of progression through cell cyclesq~Zxt0P:positive regulation of transcription from R...sq~Zt!P:intracellular protein transportsq~ZtP:cell cycle arrestsq~Zw9t%P:androgen receptor signaling pathwaysq~Z&tP:response to stresssq~Zt P:apoptosissq~ZFt(P:N-terminal peptidyl-lysine acetylationsq~Zkt&P:multicellular organismal developmentsq~Zot/P:ubiquitin-dependent protein catabolic processsq~Z>t P:cell growthsq~ZtP:cell adhesionsq~Z \t+P:positive regulation of cell proliferationsq~Z:tP:protein transportsq~Z=t%P:integrin-mediated signaling pathwaysq~ZVt P:JNK cascadesq~Z[tP:JAK-STAT cascadesq~ZWt P:carbohydrate metabolic processsq~Zt P:cell cyclesq~ZtP:transcription, DNA-dependentsq~ZtP:anti-apoptosissq~Zzt0P:negative regulation of transcription from R...sq~Z`tP:homeostatic processsq~Zt(P:nuclear mRNA splicing, via spliceosomesq~ZtP:skeletal developmentsq~ZtP:response to hypoxiasq~ZEt0P:positive regulation of transcription, DNA-d...sq~Z9tP:protein foldingsq~ZtP:transcription terminationsq~Z$ZtP:protein secretionsq~ZtP:induction of apoptosissq~Zt$P:central nervous system developmentsq~ZtP:ectoderm developmentsq~ZtP:brain developmentsq~ZtP:gastrulationsq~ZctP:cell-cell signalingsq~ZdtP:synaptic transmissionsq~ZtP:axon guidancesq~Z|tP:sex differentiationsq~Zbt!P:Rho protein signal transductionsq~ZKtP:protein kinase cascadesq~ZtP:cell motilitysq~Zt"P:regulation of muscle contractionsq~Z+tP:immune responsesq~ZHtP:ER-nuclear signaling pathwaysq~ZJtP:response to unfolded proteinsq~ZYt0P:chromosome organization and biogenesis (sen...sq~Zbt*P:cytoskeleton organization and biogenesissq~Zt-P:mitotic spindle organization and biogenesissq~Zt P:chemotaxissq~Zt P:mitosissq~Zt0P:negative regulation of epidermal growth fac...sq~Z t0P:transforming growth factor beta receptor co...sq~ZtP:SMAD protein complex assemblysq~ZJt!P:intracellular signaling cascadesq~Zt0P:epidermal growth factor receptor signaling ...sq~Zȍt'P:regulation of oxidoreductase activitysq~Zt+P:early endosome to late endosome transportsq~Z:t"P:negative regulation of apoptosissq~Z#t0P:protein ubiquitination during ubiquitin-dep...sq~ZNt0P:long-term strengthening of neuromuscular ju...sq~Zt0P:negative regulation of activin receptor sig...sq~Z~t0P:positive regulation of proteasomal ubiquiti...sq~Z|t0P:regulation of glucocorticoid metabolic processsq~Zzt/P:positive regulation of protein ubiquitinationsq~ZxtP:prostate gland developmentsq~Zwst0P:ubiquitin-dependent SMAD protein catabolic ...sq~Z0t0P:intermediate filament cytoskeleton organiza...sq~ZwtP:basal protein localizationsq~Zt0P:establishment and/or maintenance of epithel...sq~ZǓt0P:positive regulation of transcription factor...sq~ZIt!P:actin filament bundle formationsq~Z't#P:regulation of synaptic plasticitysq~ZtP:focal adhesion formationsq~Zt0P:positive regulation of Ras protein signal t...sq~Zt$P:positive regulation of JNK cascadesq~ZɔtP:protein maturationsq~ZDt0P:negative regulation of transcription, DNA-d...sq~Zt0P:positive regulation of striated muscle deve...sq~ZtP:regulation of transcriptionsq~Zw2t.P:negative regulation of BMP signaling pathwaysq~Zw0t0P:negative regulation of transforming growth ...sq~Z@tP:protein ubiquitinationsq~Z?EtP:endosome transportsq~Z?@tP:vesicle-mediated transportsq~Z&tP:organ morphogenesissq~Z&t!P:embryonic pattern specificationsq~Z%t$P:anatomical structure morphogenesissq~Z!t0P:induction of apoptosis by intracellular sig...sq~Z!t.P:release of cytoplasmic sequestered NF-kappaBsq~Z [tP:cell proliferationsq~ZtP:protein localizationsq~Z@tP:histone acetylationsq~ZBwt0P:regulation of transforming growth factor be...sq~ZCtP:regulation of exocytosissq~Zw/t0P:positive regulation of transforming growth ...sq~Zw-tP:BMP signaling pathwaysq~Zvt)P:ER-associated protein catabolic processsq~Zvt'P:positive regulation of cell migrationsq~ZvFtP:regulation of ossificationsq~ZutP:cell differentiationsq~Zut P:hemopoiesissq~ZMstP:stem cell maintenancesq~ZKt0P:cytokine and chemokine mediated signaling p...sq~ZJhtP:virus-host interactionsq~ZtP:phototransductionsq~Zt0P:retrograde vesicle-mediated transport, Golg...sq~ZtP:nucleosome disassemblysq~Zt0P:establishment and/or maintenance of chromat...sq~ZtP:nucleotide-excision repairsq~Zt P:DNA repairsq~ZstP:DNA metabolic processsq~Z<t,P:protein import into nucleus, translocationsq~Zrt0P:regulation of I-kappaB kinase/NF-kappaB cas...sq~ZRt'P:G1/S transition of mitotic cell cyclesq~ZtP:protein polyubiquitinationsq~ZtP:chromatin remodelingsq~Zt0P:regulation of transcription from RNA polyme...sq~Zt P:transportsq~ZtP:cell fate determinationsq~ZtP:protein export from nucleussq~ZptP:ubiquitin cyclesq~Z@tP:protein modification processsq~Z=tP:protein complex assemblysq~Z.t(P:regulation of translational initiationsq~Z t P:translationsq~ZtP:RNA export from nucleussq~Zt0P:transcription initiation from RNA polymeras...sq~Z"tF:protein bindingsq~Zt tF:transcription factor activitysq~Z t$F:transcription coactivator activitysq~ZT tF:GTPase activitysq~Z]t F:DNA bindingsq~Zt F:ATP bindingsq~Zt$F:transcription corepressor activitysq~ZtF:SMAD bindingsq~Zt F:GTP bindingsq~Zt#F:ubiquitin-protein ligase activitysq~ZbtF:chromatin bindingsq~ZBt*F:protein serine/threonine kinase activitysq~Z2t$F:histone acetyltransferase activitysq~Z NtF:zinc ion bindingsq~ZtF:signal transducer activitysq~Z!t)F:phosphorylase kinase regulator activitysq~Z@t"F:transcription activator activitysq~Zt F:RNA bindingsq~ZtF:receptor activitysq~ZtF:androgen receptor bindingsq~Zt)F:transforming growth factor beta bindingsq~Zvt"F:thyroid hormone receptor bindingsq~ZwPtF:Hsp70 protein bindingsq~ZtF:aldehyde reductase activitysq~Zxt"F:receptor tyrosine kinase bindingsq~Zwt0F:transforming growth factor beta receptor, i...sq~ZxtF:TPR domain bindingsq~ZwtF:protein binding, bridgingsq~Zw@t"F:transcription regulator activitysq~ZytF:androgen bindingsq~ZMtF:protein kinase bindingsq~Zt0F:transforming growth factor beta receptor ac...sq~ZtF:androgen receptor activitysq~Zut(F:Hsp70/Hsc70 protein inhibitor activitysq~Z@tF:protein kinase activitysq~Zvt0F:ligand-dependent nuclear receptor transcrip...sq~ZʧtF:Hsp90 protein bindingsq~ZctF:MAP kinase activitysq~ZVt0F:eukaryotic translation initiation factor 2a...sq~ZytF:MyoD bindingsq~ZMtF:kinase bindingsq~Zyt0F:RNA splicing factor activity, transesterifi...sq~Zzt0F:ligand-regulated transcription factor activitysq~Zt%F:protein heterodimerization activitysq~ZztF:ubiquitin bindingsq~Z-tF:sequence-specific DNA bindingsq~Zyt0F:RNA polymerase II transcription factor acti...sq~Zvt0F:RNA polymerase II transcription factor acti...sq~Z~t0F:histone lysine N-methyltransferase activity...sq~ZqtF:single-stranded DNA bindingsq~ZdtF:damaged DNA bindingsq~ZtF:virion bindingsq~ZJtF:histone deacetylase bindingsq~Z9tF:vitamin D receptor bindingsq~Zt$F:structural constituent of ribosomesq~Z9tF:activin bindingsq~Z8tF:follistatin bindingsq~Zt0F:RNA polymerase II transcription termination...sq~Zt+F:transcription termination factor activitysq~ZtF:SH2 domain bindingsq~Z}tF:protein N-terminus bindingsq~Zt!F:transcription cofactor activitysq~ZtF:protein dimerization activitysq~Z3t#F:protein homodimerization activitysq~ZtF:magnesium ion bindingsq~Zt%F:receptor signaling protein activitysq~Zt0F:hematopoietin/interferon-class (D200-domain...sq~Z@Gt0F:RNA polymerase II transcription mediator ac...sq~Z@tF:acetyltransferase activitysq~Z:tF:integrin bindingsq~ZPt(F:structural constituent of cytoskeletonsq~Z_tF:transporter activitysq~ZVtF:protein C-terminus bindingsq~ZtF:tropomyosin bindingsq~Z#_tF:electron carrier activitysq~ZtF:N-acetyltransferase activitysq~ZtF:transcription factor bindingsq~ZtF:DNA-dependent ATPase activitysq~Z tF:methyl-CpG bindingsq~Z mtF:DNA bending activitysq~Z8tF:ErbB-2 class receptor bindingsq~Z@t"F:transcription repressor activitysq~Zt F:interleukin-1 receptor bindingsq~ZKt F:phosphatase regulator activitysq~ZtF:SH3/SH2 adaptor activitysq~Z2tF:identical protein bindingsq~Zt0F:transforming growth factor beta receptor, c...sq~Zt,F:guanyl-nucleotide exchange factor activitysq~Zt0F:Rho guanyl-nucleotide exchange factor activitysq~Zt0F:translation factor activity, nucleic acid b...sq~ZtF:GTPase activator activitysq~ZA t0F:oxidoreductase activity, acting on NADH or ...sq~Z t C:nucleussq~Zit C:cytoplasmsq~ZtC:intracellularsq~Z>tC:integral to membranesq~ZWt)C:transcription elongation factor complexsq~Z>t C:membranesq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZwtC:mediator complexsq~Z1t C:spliceosomesq~Zt C:cytosolsq~ZtC:ubiquitin ligase complexsq~ZtC:integral to plasma membranesq~ZtC:extracellular spacesq~Zt#C:histone methyltransferase complexsq~ZtC:membrane fractionsq~Zt C:spindlesq~ZtC:nuclear chromosomesq~Zt C:Golgi stacksq~ZtC:Golgi apparatussq~ZtC:early endosomesq~Zt C:lysosomesq~ZktC:mitochondrionsq~Z3tC:activin receptor complexsq~ZtC:basement membranesq~Zt&C:cytosolic ribosome (sensu Eukaryota)sq~Zt0C:proteasome regulatory particle (sensu Eukar...sq~Zt C:ribosomesq~Z@tC:nuclear bodysq~ZBt#C:transcriptional repressor complexsq~ZutC:AP-2 adaptor complexsq~ZtC:plasma membranesq~ZuhtC:hemidesmosomesq~Z@tC:CCAAT-binding factor complexsq~Zbt C:nucleolussq~Z5tC:Elongator core complexsq~ZtC:extracellular regionsq~Z}tC:cleavage furrowsq~ZtC:protein complexsq~Zzt&C:ubiquitin conjugating enzyme complexsq~ZUtC:synaptic vesiclesq~ZtC:nuclear envelopesq~Zt$C:integral to nuclear inner membranesq~Z tC:nuclear poresq~Zt C:nucleoplasmsq~Z#tC:transcription factor complexsq~Z'tC:cell surfacesq~ZtC:photoreceptor outer segmentsq~Z>t C:chromosomesq~ZtC:condensed nuclear chromosomesq~Z@t,C:DNA-directed RNA polymerase II, holoenzymesq~Zt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Z%tC:focal adhesionpppppppppppppppppppppppppppppppppppppxsq~uq~ sq~tP:BMP signaling pathwayt30509sq~t!P:embryonic pattern specificationt9880sq~t0P:transforming growth factor beta receptor si...t7179sq~tF:protein bindingt5515sq~t%F:receptor signaling protein activityt5057sq~t"F:transcription activator activityt16563sq~tC:integral to membranet16021sq~t C:nucleust5634ppxsq~uq~ sq~t IPR013790tDwarfinsq~t IPR013019tMAD_MH1sq~t IPR003619tMH1_Dwarfin-typesq~t IPR001132tMH2_Dwarfin-typeppppppxsq~uq~ sq~tMH1tPF03165sq~tMH2tPF03166ppppppppxtQ15797t SMAD1_HUMANsq~uq~ sq~tSMAD 1sq~tMothers against DPP homolog 1sq~tMad-related protein 1sq~t3Transforming growth factor-beta-signaling protein 1sq~tBSP-1sq~thSMAD1sq~tJV4-1pppxt Homo sapienstKIF3Csq~P?UUUUUOd0%tKinesin-like protein KIF3Csq~uq~ sq~Ud0tENSG00000084731pppppppppxsq~uq~ sq~md0tKIF3Cpppppppppxsq~uq~ sq~Zd0t,P:regulation of transcription, DNA-dependentsq~ZTd0t'P:organelle organization and biogenesissq~Zd0tF:protein bindingsq~Z]d0t F:DNA bindingsq~Zd0t&C:proteasome complex (sensu Eukaryota)sq~Zd0t C:nucleusppppxsq~uq~ sq~d0tF:motor activityt3774sq~d0tC:kinesin complext5871ppppppppxsq~uq~ sq~d0t IPR001752t kinesin_motorpppppppppxsq~uq~ sq~d0tKinesintPF00225pppppppppxtO14782t KIF3C_HUMANpt Homo sapienstPLK1sq~P?O3E4%t$Serine/threonine-protein kinase PLK1sq~uq~ sq~UEtENSG00000166851pppppppppxsq~uq~ sq~mEtPLK1sq~mEtPLKppppppppxsq~uq~ sq~Z [EtP:cell proliferationsq~ZEt,P:regulation of transcription, DNA-dependentsq~ZkEt&P:multicellular organismal developmentsq~ZEtP:regulation of mitosissq~ZEtP:signal transductionsq~ZEt P:cell agingsq~ZoEt/P:ubiquitin-dependent protein catabolic processsq~ZEtP:anti-apoptosissq~ZJEt.P:regulation of progression through cell cyclesq~ZtEtP:DNA replicationsq~ZEtP:nucleotide-excision repairsq~ZOEt0P:regulation of cyclin-dependent protein kina...sq~ZEt/P:transcription from RNA polymerase II promotersq~ZEtP:cell cycle arrestsq~Z!Et0P:DNA damage response, signal transduction re...sq~ZEt0P:traversing start control point of mitotic c...sq~ZEt-P:regulation of S phase of mitotic cell cyclesq~ZEtP:base-excision repairsq~ZEt0P:mitotic cell cycle spindle assembly checkpointsq~ZEt P:cell cyclesq~ZGEtP:ER overload responsesq~Z>Et!P:response to DNA damage stimulussq~ZEtP:induction of apoptosissq~ZEtP:lipid metabolic processsq~ZEtP:calcium ion transportsq~ZEt"P:cellular calcium ion homeostasissq~ZEt!P:intracellular protein transportsq~ZEtP:nucleocytoplasmic transportsq~ZEtP:double-strand break repairsq~ZEtP:cell motilitysq~Z&EtP:response to stresssq~ZEt0P:transcription-coupled nucleotide-excision r...sq~ZEtP:centrosome cyclesq~ZEt0P:regulation of progression through mitotic c...sq~ZUEtP:regulation of phosphorylationsq~ZEt0P:DNA damage response, signal transduction by...sq~ZsEt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZkEtP:response to estrogen stimulussq~ZEt(P:protein amino acid autophosphorylationsq~Z6Et0P:regulation of mitochondrial membrane permea...sq~ZEt0P:negative regulation of epithelial cell prol...sq~ZǔEt.P:activation of NF-kappaB transcription factorsq~ZǙEt*P:negative regulation of helicase activitysq~Z>EtP:protein tetramerizationsq~ZEt+P:natural killer cell mediated cytotoxicitysq~ZEtP:ribosome assemblysq~ZEt)P:cellular response to glucose starvationsq~ZEtP:phototransductionsq~ZEtP:long-term memorysq~ZEtP:protein localizationsq~Z ]Et+P:negative regulation of cell proliferationsq~Z!Et%P:caspase activation via cytochrome csq~ZEt0P:negative regulation of ubiquitin ligase act...sq~ZvdEt$P:negative regulation of cell growthsq~ZEtP:cytokinesis during cell cyclesq~Z;EtP:response to genisteinsq~Z@Et0P:negative regulation of mammary gland epithe...sq~ZbEtP:centrosome duplicationsq~ZEt P:DNA repairsq~Z~EtP:DNA replication initiationsq~ZEtP:regulation of apoptosissq~ZEt-P:meiotic spindle organization and biogenesissq~ZVEt'P:G2/M transition of mitotic cell cyclesq~ZMEtP:DNA damage checkpointsq~ZEtP:brain developmentsq~ZEtP:mitotic spindle elongationsq~ZyEtP:DNA topological changesq~ZEtF:protein bindingsq~ZEt F:RNA bindingsq~ZtEtF:transcription factor activitysq~ZOEtF:endopeptidase activitysq~Z]Et F:DNA bindingsq~Z@EtF:protein kinase activitysq~ZEtF:signal transducer activitysq~Z NEtF:zinc ion bindingsq~ZEt F:ATP bindingsq~ZEt%F:protein heterodimerization activitysq~ZuEtF:chaperone regulator activitysq~Z@Et"F:transcription activator activitysq~ZEt0F:Ras guanyl-nucleotide exchange factor activitysq~ZBEt*F:protein serine/threonine kinase activitysq~ZEtF:nuclease activitysq~ZxEtF:Tat protein bindingsq~ZEtF:microtubule motor activitysq~ZNJEtF:unfolded protein bindingsq~ZsEtF:NF-kappaB bindingsq~Z}EtF:protein N-terminus bindingsq~ZEtF:3'-5' DNA helicase activitysq~ZEtF:gamma-tubulin bindingsq~Z3Et#F:protein homodimerization activitysq~ZMEtF:enzyme bindingsq~Z0EtF:MHC class I protein bindingsq~Z^EtF:DNA helicase activitysq~ZdEtF:damaged DNA bindingsq~ZEt$F:transcription coactivator activitysq~Z!NEt+F:phosphatidylinositol transporter activitysq~ZiEt"F:protein-tyrosine kinase activitysq~ZkEt0F:non-membrane spanning protein tyrosine kina...sq~ZEtF:calcium ion bindingsq~ZEtF:copper ion bindingsq~ZEtF:DNA strand annealing activitysq~ZPEt(F:structural constituent of cytoskeletonsq~ZEtF:DNA-dependent ATPase activitysq~ZEtF:transcription factor bindingsq~ZuEt'F:protein tyrosine phosphatase activitysq~Z Et&C:proteasome complex (sensu Eukaryota)sq~Z Et C:nucleussq~ZiEt C:cytoplasmsq~ZbEt C:nucleolussq~ZEt C:centrosomesq~ZEt+C:proteasome core complex (sensu Eukaryota)sq~ZEt C:spindlesq~ZEtC:spindle pole bodysq~ZEt C:chromatinsq~ZEtC:endoplasmic reticulumsq~ZEt C:nucleoplasmsq~ZEtC:membrane fractionsq~ZEt&C:alpha DNA polymerase:primase complexsq~ZuEtC:secretory granulesq~ZMEt C:synaptosomesq~Z@Et C:PML bodysq~Z?EtC:nuclear matrixsq~ZEtC:polar microtubulesq~Z>Et C:membranesq~ZEt C:polysomesq~ZEtC:cytoskeletonsq~ZEtC:plasma membranesq~ZEtC:kinesin complexsq~ZEt C:kinetochoresq~ZEtC:extracellular spacesq~Z+EtC:holo TFIIH complexsq~Z9EtC:BRCA2-MAGE-D1 complexsq~ZEtC:gamma-tubulin complexsq~ZkEtC:mitochondrionsq~ZEtC:multivesicular bodysq~ZEtC:insoluble fractionsq~ZEtC:condensed nuclear chromosomesq~ZEtC:Golgi apparatussq~ZEtC:protein complexsq~Z;Et C:MCM complexppppppppppppppppppppxsq~uq~ sq~EtP:cell proliferationt8283sq~Et P:mitosist7067sq~Et.P:regulation of progression through cell cyclet74sq~EtF:protein bindingt5515sq~Et*F:protein serine/threonine kinase activityt4674sq~Et C:centrosomet5813ppppxsq~uq~ sq~Et IPR015728tPolo-like_kinasesq~Et IPR000959tPOLO_boxsq~Et IPR000719tProt_kinase_coresq~Et IPR008271tSer_thr_pkin_ASsq~Et IPR002290tSer_thr_pkinasepppppxsq~uq~ sq~EtPkinasetPF00069sq~EtPOLO_boxtPF00659ppppppppxtP53350t PLK1_HUMANsq~uq~ sq~EtPolo-like kinase 1sq~EtPLK-1sq~Et"Serine/threonine-protein kinase 13sq~EtSTPK13ppppppxt Homo sapienstDCP2sq~P?ʹ;%tmRNA-decapping enzyme 2sq~uq~ sq~U;tENSG00000172795pppppppppxsq~uq~ sq~m;tDCP2sq~m;tNUDT20ppppppppxsq~uq~ (sq~Z;t0P:mRNA catabolic process, nonsense-mediated d...sq~Zt;tP:DNA replicationsq~Z;tP:mRNA export from nucleussq~Z;t'P:N-acetylglucosamine metabolic processsq~Z;t'P:N-acetylmannosamine metabolic processsq~Z;t P:DNA repairsq~Z;tP:RNA processingsq~Z;tP:mRNA catabolic processsq~Z ;t P:translationsq~Z.;t(P:regulation of translational initiationsq~Z1;t)P:regulation of translational terminationsq~Z;t P:cell cyclesq~Z ;tF:protein bindingsq~Z;t(F:translation initiation factor activitysq~Zb;tF:chromatin bindingsq~Z;t F:RNA bindingsq~Zo;t(F:nucleocytoplasmic transporter activitysq~Z;t0F:[pyruvate dehydrogenase (lipoamide)] phosph...sq~Z;t%F:ATP-dependent RNA helicase activitysq~Z;tF:single-stranded RNA bindingsq~Z;tF:mRNA bindingsq~Z;t C:nucleussq~Zi;t C:cytoplasmsq~Z;t0C:eukaryotic translation initiation factor 2 ...sq~Z;t C:cytosolsq~Z;t C:chromatinsq~Z;t&C:proteasome complex (sensu Eukaryota)pppppppppppppxsq~uq~ sq~;tF:protein bindingt5515pppppppppxsq~uq~ sq~;t IPR007722tDCP2sq~;t IPR000086tNUDIX_hydrolaseppppppppxsq~uq~ sq~;tDCP2tPF05026sq~;tNUDIXtPF00293ppppppppxtQ8IU60t DCP2_HUMANsq~uq~ sq~;thDpcsq~;t/Nucleoside diphosphate-linked moiety X motif 20sq~;tNudix motif 20pppppppxt Homo sapienstUBQL1sq~P?Xƕ1Kr2%t Ubiquilin-1sq~uq~ sq~UKrtENSG00000135018pppppppppxsq~uq~ sq~mKrtUBQLN1sq~mKrtDA41sq~mKrtPLIC1pppppppxsq~auq~ sq~ZKrtP:signal transductionsq~ZKrt P:transportsq~ZKrtP:nervous system developmentsq~ZJKrt.P:regulation of progression through cell cyclesq~Z@eKrtP:protein processingsq~Z4KrtP:Notch receptor processingsq~ZmKrt)P:membrane protein ectodomain proteolysissq~ZdKrtP:synaptic transmissionsq~ZKrt-P:amyloid precursor protein catabolic processsq~ZYKrt0P:chromosome organization and biogenesis (sen...sq~ZMKrt(P:positive regulation of enzyme activitysq~ZKrtP:chromosome segregationsq~ZWKrt P:carbohydrate metabolic processsq~ZgKrt$P:synaptic transmission, cholinergicsq~ZKrtP:mRNA cleavagesq~ZJKrtP:response to unfolded proteinsq~ZKrtP:response to nutrientsq~ZKrt P:digestionsq~Z [KrtP:cell proliferationsq~Z \Krt+P:positive regulation of cell proliferationsq~Z.Krt+P:gamma-aminobutyric acid signaling pathwaysq~ZKrtP:nucleotide-excision repairsq~ZKrt0P:epidermal growth factor receptor signaling ...sq~ZKrt0P:RNA elongation from RNA polymerase II promotersq~ZKrtP:mRNA polyadenylationsq~Z9KrtP:protein foldingsq~ZoKrt/P:ubiquitin-dependent protein catabolic processsq~Z=Krt%P:integrin-mediated signaling pathwaysq~ZKrtP:anti-apoptosissq~ZKrtP:cell motilitysq~Z ]Krt+P:negative regulation of cell proliferationsq~Z?KrtP:phosphorylationsq~ZGKrt0P:peptidyl-proline hydroxylation to 4-hydroxy...sq~ZZKrt)P:negative regulation of JAK-STAT cascadesq~ZuKrtP:protein catabolic processsq~Z?EKrtP:endosome transportsq~Z>Krt%P:vesicle organization and biogenesissq~Z>Krt P:cell growthsq~ZUKrtP:regulation of phosphorylationsq~ZPKrt*P:regulation of neurotransmitter secretionsq~ZWKrt+P:positive regulation of cell-cell adhesionsq~ZƶKrt*P:positive regulation of T cell activationsq~Z!KrtP:apoptotic programsq~Z+KrtP:immune responsesq~ZKrtP:proteasome assemblysq~ZKrtF:protein bindingsq~ZKrt C:membranesq~Z>KrtC:integral to membranesq~ZkKrtC:mitochondrionsq~Z'KrtC:cell surfacepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~KrtF:kinase bindingt19900sq~Krt!C:perinuclear region of cytoplasmt48471sq~KrtC:protein complext43234pppppppxsq~uq~ sq~Krt IPR006636t STI1_HS_bdsq~Krt IPR000449tUBA/Transl_elong_EF1B_Nsq~Krt IPR015496t Ubiquilinsq~Krt IPR000626t Ubiquitinppppppxsq~uq~ sq~KrtUBAtPF00627sq~Krt ubiquitintPF00240ppppppppxtQ9UMX0t UBQL1_HUMANsq~uq~ sq~Krt'Protein linking IAP with cytoskeleton 1sq~KrtPLIC-1sq~KrthPLIC-1pppppppxt Homo sapienstVIMEsq~P?E%tVimentinsq~uq~ sq~UEtENSG00000026025pppppppppxsq~uq~ sq~mEtVIMpppppppppxsq~%uq~ @sq~ZEtP:signal transductionsq~ZDEt$P:protein amino acid phosphorylationsq~ZEt,P:regulation of transcription, DNA-dependentsq~ZsEt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZEtP:anti-apoptosissq~ZEt/P:transcription from RNA polymerase II promotersq~ZEtP:cell adhesionsq~ZEtP:induction of apoptosissq~ZlEt P:proteolysissq~ZEt$P:central nervous system developmentsq~Z ]Et+P:negative regulation of cell proliferationsq~Z*EtP:inflammatory responsesq~ZEt0P:nucleobase, nucleoside, nucleotide and nucl...sq~ZEt!P:intercellular junction assemblysq~ZuTEt0P:actin cytoskeleton organization and biogenesissq~Z+EtP:immune responsesq~ZEt0P:positive regulation of gene-specific transc...sq~ZvEtP:keratinocyte differentiationsq~Z:Et"P:negative regulation of apoptosissq~ZEtP:homophilic cell adhesionsq~ZFEtP:peptide cross-linkingsq~ZEtP:nucleotide-excision repairsq~ZEtP:nervous system developmentsq~Z%Et$P:anatomical structure morphogenesissq~ZEt(P:protein amino acid autophosphorylationsq~ZEt0P:regulation of transcription from RNA polyme...sq~ZEt P:mitosissq~Z=EtP:protein complex assemblysq~ZEEt0P:negative regulation of protein kinase activitysq~ZEtP:regulation of cell growthsq~ZdEtP:synaptic transmissionsq~ZuEt&P:positive regulation of transcriptionsq~Z!EtP:apoptotic programsq~ZzEt0P:negative regulation of transcription from R...sq~ZJEt.P:regulation of progression through cell cyclesq~Z<EtP:protein homooligomerizationsq~ZEt0P:transmembrane receptor protein tyrosine kin...sq~ZEt0P:cell surface receptor linked signal transdu...sq~ZEt*P:calcium-independent cell-matrix adhesionsq~ZEtP:signal complex assemblysq~ZYEtP:activation of JNK activitysq~Z[EtP:JAK-STAT cascadesq~ZJEt!P:intracellular signaling cascadesq~ZbEt!P:Rho protein signal transductionsq~Z2Et P:neuropeptide signaling pathwaysq~ZEt0P:G-protein coupled receptor protein signalin...sq~ZkEt&P:multicellular organismal developmentsq~ZQEt#P:I-kappaB kinase/NF-kappaB cascadesq~Z Et0P:transforming growth factor beta receptor si...sq~ZEtP:meiotic recombinationsq~ZEt P:apoptosissq~ZlEtP:microtubule nucleationsq~ZEt(P:ER to Golgi vesicle-mediated transportsq~ZEtP:calcium ion transportsq~ZEt P:transportsq~ZEt+P:NLS-bearing substrate import into nucleussq~Z"EtP:icosanoid metabolic processsq~ZEt0P:platelet activating factor biosynthetic pro...sq~ZEt P:chemotaxissq~Z8EtP:cellular defense responsesq~ZEt0P:establishment and/or maintenance of chromat...sq~ZEtP:cell cycle arrestsq~ZEtP:cell motilitysq~ZhEtP:cytoskeletal anchoringsq~ZbEt*P:cytoskeleton organization and biogenesissq~Z^Et0P:mitochondrial membrane organization and bio...sq~ZYEt0P:chromosome organization and biogenesis (sen...sq~ZCEtP:response to oxidative stresssq~ZIEt P:protein amino acid acetylationsq~Z|EtP:female gamete generationsq~ZǢEt%P:positive regulation of DNA ligationsq~Z$Et0P:positive regulation of protein kinase activitysq~ZrEt%P:regulation of epidermis developmentsq~Z`Et&P:regulation of neuron differentiationsq~Z2Et0P:positive regulation of keratinocyte differe...sq~ZxEtP:apical protein localizationsq~Z5Et$P:intermediate filament organizationsq~ZEtP:innate immune responsesq~ZEt0P:positive regulation of interleukin-2 biosyn...sq~ZEtP:T cell selectionsq~ZEt.P:mitochondrial fragmentation during apoptosissq~Z!EtP:apical junction assemblysq~ZDEt0P:negative regulation of transcription, DNA-d...sq~ZfEtP:negative regulation of growthsq~ZǔEt.P:activation of NF-kappaB transcription factorsq~ZHEt#P:barbed-end actin filament cappingsq~Z&Et"P:detection of mechanical stimulussq~Z Et+P:sensory perception of mechanical stimulussq~ZƯEt!P:regulation of T cell activationsq~ZƤEt#P:T cell receptor signaling pathwaysq~ZlEt!P:regulation of insulin secretionsq~ZEt0P:positive regulation of epithelial cell prol...sq~Z'Et#P:regulation of synaptic plasticitysq~Z]EtP:response to arsenicsq~ZEtP:uridine metabolic processsq~ZEt0P:proteasomal ubiquitin-dependent protein cat...sq~Z=Et.P:negative regulation of programmed cell deathsq~Z&EtP:organ morphogenesissq~Z%EtP:response to bacteriumsq~Z%EtP:response to virussq~Z#Et.P:nucleoside triphosphate biosynthetic processsq~Z!Et%P:caspase activation via cytochrome csq~Z!Et0P:induction of apoptosis by extracellular sig...sq~Z!`EtP:epidermis developmentsq~Z EtP:RNA splicingsq~Z \Et+P:positive regulation of cell proliferationsq~Z [EtP:cell proliferationsq~ZEtP:visual perceptionsq~Z&Et#P:regulation of signal transductionsq~Z'1EtP:response to organic substancesq~ZEt*P:cytoplasmic sequestering of CFTR proteinsq~ZEt)P:regulation of protein catabolic processsq~ZvEt'P:negative regulation of cell migrationsq~Zv8Et(P:nuclear fragmentation during apoptosissq~Zu_EtP:actin modificationsq~ZuPEtP:lamellipodium biogenesissq~ZKEt0P:cytokine and chemokine mediated signaling p...sq~Z@EtP:protein ubiquitinationsq~Z@aEt&P:negative regulation of transcriptionsq~Z:EtP:protein transportsq~Z'EtP:response to UV-Bsq~ZSEtP:heart developmentsq~ZGEt%P:protein amino acid ADP-ribosylationsq~Z&Et.P:very-long-chain fatty acid metabolic processsq~Z-Et&P:epithelial to mesenchymal transitionsq~ZEtP:cartilage condensationsq~ZEtP:MAPKKK cascadesq~ZEt0P:microtubule cytoskeleton organization and b...sq~ZEt0P:double-strand break repair via homologous r...sq~ZEt"P:conjugation with cellular fusionsq~ZɗEtP:defense response to virussq~ZWEt P:carbohydrate metabolic processsq~ZtEtP:DNA replicationsq~Z@EtP:protein modification processsq~Z.Et(P:regulation of translational initiationsq~ZEt0P:transcription from RNA polymerase III promotersq~ZEtP:transcription, DNA-dependentsq~ZEtP:mitotic recombinationsq~ZEtP:DNA recombinationsq~ZEt0P:double-strand break repair via nonhomologou...sq~Z|Et"P:DNA unwinding during replicationsq~Z:EtF:protein bindingsq~Zt EtF:transcription factor activitysq~ZP Et(F:structural constituent of cytoskeletonsq~Z2 EtF:identical protein bindingsq~ZEtF:signal transducer activitysq~ZEt F:ATP bindingsq~ZBEt*F:protein serine/threonine kinase activitysq~ZqEtF:single-stranded DNA bindingsq~Z NEtF:zinc ion bindingsq~ZwEtF:caspase activitysq~ZTEtF:GTPase activitysq~ZwEtF:protein binding, bridgingsq~Z]Et F:DNA bindingsq~ZMEtF:protein kinase bindingsq~ZvBEtF:LIM domain bindingsq~ZKEtF:intermediate filament bindingsq~ZEtF:actin bindingsq~ZEtF:motor activitysq~ZMEtF:enzyme bindingsq~ZCEtF:vinculin bindingsq~ZEt!F:transcription cofactor activitysq~ZEt F:uridine phosphorylase activitysq~Z *Et"F:cysteine-type peptidase activitysq~ZEt)F:tumor necrosis factor receptor activitysq~ZeEt#F:MAP kinase kinase kinase activitysq~ZEt#F:ubiquitin-protein ligase activitysq~Z@Et"F:transcription repressor activitysq~ZEt0F:mannosyl-oligosaccharide 1,3-1,6-alpha-mann...sq~ZvHEt%F:structural constituent of epidermissq~ZAEtF:ATPase activitysq~ZBEtF:GTP-Rho bindingsq~ZBEtF:SH3 domain bindingsq~ZC Et0F:negative regulator of basal transcription a...sq~Z@EtF:protein kinase activitysq~ZSEt(F:cAMP-dependent protein kinase activitysq~ZiEt"F:protein-tyrosine kinase activitysq~ZEtF:phospholipase A2 activitysq~ZUEt*F:cyclin-dependent protein kinase activitysq~Zw3EtF:snoRNA bindingsq~ZEt F:RNA bindingsq~ZEt$F:transcription corepressor activitysq~ZgEtF:myosin II bindingsq~ZEtF:alpha-catenin bindingsq~ZyEt0F:RNA polymerase II transcription factor acti...sq~ZjEtF:double-stranded DNA bindingsq~ZEtF:glycoprotein bindingsq~Z}EtF:protein N-terminus bindingsq~ZEtF:syntaxin-6 bindingsq~Z EtF:CARD domain bindingsq~ZsEtF:NF-kappaB bindingsq~ZEt(F:translation initiation factor activitysq~ZsEt+F:long-chain-fatty-acid-CoA ligase activitysq~Z{+Et0F:thyrotropin-releasing hormone receptor bindingsq~ZEt$F:transcription coactivator activitysq~ZEt(F:nucleoside diphosphate kinase activitysq~Z1EtF:MHC class II protein bindingsq~Z=EtF:phosphate bindingsq~Z3Et#F:protein homodimerization activitysq~ZEt0F:cystic fibrosis transmembrane conductance r...sq~Z6Et*F:H3/H4 histone acetyltransferase activitysq~Z=EtF:dihydropyrimidinase activitysq~ZEt%F:ATP-dependent DNA helicase activitysq~ZtEt0F:NAD(P)+-protein-arginine ADP-ribosyltransfe...sq~ZEtF:recombinase activitysq~ZEt/F:single-stranded DNA-dependent ATPase activitysq~Z_EtF:transporter activitysq~ZEtF:calcium channel activitysq~Z_EtF:ATP:ADP antiporter activitysq~ZEtF:fatty acid bindingsq~Z Et%F:protein kinase C inhibitor activitysq~Z sEt"F:structural constituent of musclesq~Z KEtF:poly-glutamine tract bindingsq~ZEtF:transcription factor bindingsq~ZoEtF:enzyme activator activitysq~ZVEtF:protein C-terminus bindingsq~Z\Et$F:structural constituent of eye lenssq~ZQEt-F:extracellular matrix structural constituentsq~Z:EtF:coreceptor activitysq~Z'Et-F:insulin-like growth factor receptor bindingsq~Z@Et"F:transcription activator activitysq~ZEtF:protein kinase C bindingsq~Z@kEtF:oxidoreductase activitysq~ZEt!F:transmembrane receptor activitysq~ZEtF:receptor activitysq~Z;EtF:porin activitysq~ZEt C:nucleussq~ZiEt C:cytoplasmsq~ZEtC:intermediate filamentsq~ZEtC:plasma membranesq~Z>EtC:integral to membranesq~ZEt C:cytosolsq~ZEtC:cytoskeletonsq~Z= EtC:actin cytoskeletonsq~ZEt&C:proteasome complex (sensu Eukaryota)sq~Z%EtC:focal adhesionsq~Z#EtC:transcription factor complexsq~ZEtC:cornified envelopesq~ZEtC:protein complexsq~ZEtC:insoluble fractionsq~ZEtC:membrane fractionsq~ZEtC:integral to plasma membranesq~ZEtC:rufflesq~ZEtC:spindle polesq~ZEt C:centrosomesq~ZEtC:intercellular junctionsq~Z{EtC:apical cortexsq~ZEt C:polysomesq~ZEt0C:proteasome regulatory particle (sensu Eukar...sq~ZEtC:cytoplasmic dynein complexsq~ZEt0C:eukaryotic translation initiation factor 3 ...sq~ZEt C:microtubule associated complexsq~ZEtC:spindle microtubulesq~Z@Et'C:cAMP-dependent protein kinase complexsq~ZEtC:Golgi membranesq~Z#EtC:tight junctionsq~ZEtC:cell-cell adherens junctionsq~ZEt C:kinetochoresq~ZEtC:plus-end kinesin complexsq~ZEtC:cytoplasmic partsq~Z)EtC:ciliumsq~ZEtC:neurofilamentsq~ZEtC:condensed nuclear chromosomesq~ZBEt0C:calcium- and calmodulin-dependent protein k...sq~ZEtC:microtubule organizing centersq~Z}EtC:cleavage furrowsq~Z|EtC:mitochondrial membranesq~Z REtC:gamma-tubulin ring complexsq~ZEtC:intracellularsq~ZEtC:extracellular regionsq~Zw Et C:midbodysq~ZvEtC:axonsq~Z qEtC:integrin complexsq~ZuEt'C:trans-Golgi network transport vesiclesq~ZuiEt C:desmosomesq~ZuKEtC:lamellipodiumsq~ZMEtC:outer membranesq~ZEt#C:histone methyltransferase complexsq~ZuEtC:T cell receptor complexsq~ZEtC:soluble fractionsq~Z*Et C:type III intermediate filamentsq~Z'EtC:keratin filamentsq~ZEtC:cis-Golgi networksq~ZEt C:endoplasmic reticulum membranesq~ZEtC:endoplasmic reticulumsq~ZpEt0C:mitochondrial inner membrane presequence tr...sq~ZkEtC:mitochondrionsq~ZdEt+C:small nucleolar ribonucleoprotein complexsq~ZbEt C:nucleolussq~Z1Et C:spliceosomesq~ZEt C:nucleoplasmsq~ZEt C:costameresq~Z?EtC:basolateral plasma membranepppppppppppppppppppppppppppxsq~uq~ sq~EtP:cell motilityt6928sq~EtF:protein bindingt5515sq~Et(F:structural constituent of cytoskeletont5200sq~Et C:cytoplasmt5737sq~EtC:intermediate filamentt5882pppppxsq~uq~ sq~Et IPR006821tfilament_DNA_bdsq~Et IPR001664tIFppppppppxsq~uq~ sq~EtFilamenttPF00038sq~Et Filament_headtPF04732ppppppppxtP08670t VIME_HUMANpt Homo sapienstPOMPsq~P?"%tProteasome maturation proteinsq~uq~ sq~U"tENSG00000132963pppppppppxsq~uq~ sq~m"tPOMPsq~m"tC13orf12sq~m"tUMP1sq~m"tHSPC014sq~m"tHSPC036sq~m"tPNAS-110ppppxsq~uq~ sq~Zo"t/P:ubiquitin-dependent protein catabolic processsq~Z"tF:protein bindingsq~ZO"tF:endopeptidase activitysq~Z"t&C:proteasome complex (sensu Eukaryota)sq~Z"t+C:proteasome core complex (sensu Eukaryota)pppppxpsq~uq~ sq~"t IPR008012tUMP1pppppppppxsq~uq~ sq~"tUMP1tPF05348pppppppppxtQ9Y244t POMP_HUMANsq~uq~ sq~"tProteassemblinsq~"tProtein UMP1 homologsq~"thUMP1sq~"t(Voltage-gated K channel beta subunit 4.1ppppppxt Homo sapienstHS90Bsq~P?F~]lm%tHeat shock protein HSP 90-betasq~uq~ sq~UtENSG00000096384pppppppppxsq~uq~ sq~mtHSP90AB1sq~mtHSP90Bsq~mtHSPC2sq~mtHSPCBppppppxsq~.uq~ @sq~ZtP:signal transductionsq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~ZDt$P:protein amino acid phosphorylationsq~ZtP:anti-apoptosissq~ZJtP:response to unfolded proteinsq~Z t P:translationsq~ZtP:cell motilitysq~Z@tP:protein modification processsq~Zt,P:regulation of transcription, DNA-dependentsq~Z [tP:cell proliferationsq~ZtP:nervous system developmentsq~ZtP:induction of apoptosissq~Zt P:glycolysissq~Zt(P:protein amino acid autophosphorylationsq~Zkt&P:multicellular organismal developmentsq~Z9tP:protein foldingsq~ZtP:transcriptionsq~ZRt)P:activation of NF-kappaB-inducing kinasesq~ZKt0P:cytokine and chemokine mediated signaling p...sq~ZOt0P:regulation of cyclin-dependent protein kina...sq~Z+tP:immune responsesq~Z*tP:inflammatory responsesq~ZtP:regulation of apoptosissq~Zǔt.P:activation of NF-kappaB transcription factorsq~Zƶt*P:positive regulation of T cell activationsq~Zt0P:G-protein coupled receptor protein signalin...sq~ZEt0P:positive regulation of transcription, DNA-d...sq~Z=tP:protein complex assemblysq~Zt P:apoptosissq~ZtP:angiogenesissq~ZƤt#P:T cell receptor signaling pathwaysq~Z t0P:positive regulation of T cell cytokine prod...sq~ZQt#P:I-kappaB kinase/NF-kappaB cascadesq~ZtP:phosphate metabolic processsq~Z=t%P:integrin-mediated signaling pathwaysq~ZTtP:I-kappaB phosphorylationsq~Zt0P:negative regulation of adenylate cyclase ac...sq~Z[tP:JAK-STAT cascadesq~Zbt!P:Rho protein signal transductionsq~ZctP:cell-cell signalingsq~ZuTt0P:actin cytoskeleton organization and biogenesissq~ZtP:protein localizationsq~ZJt!P:intracellular signaling cascadesq~ZatP:tRNA processingsq~ZtP:fluid secretionsq~ZtP:response to nutrientsq~Zt P:cell agingsq~ZtP:fatty acid metabolic processsq~ZltP:gamete generationsq~Zt.P:actin polymerization and/or depolymerizationsq~ZUt%P:nuclear organization and biogenesissq~Zt"P:regulation of muscle contractionsq~Zt(P:intra-Golgi vesicle-mediated transportsq~ZtP:striated muscle contractionsq~ZtP:mitochondrial transportsq~Z8tP:cellular defense responsesq~ZtP:phosphate transportsq~ZmtP:tubulin foldingsq~Zt P:cell cyclesq~ZtP:cell cycle arrestsq~Zt P:mitosissq~ZtP:regulation of mitosissq~ZGtP:ER overload responsesq~ZtP:meiotic recombinationsq~ZtP:cell adhesionsq~ZtP:alanyl-tRNA aminoacylationsq~Z t0P:transforming growth factor beta receptor si...sq~Zt#P:nitric oxide biosynthetic processsq~Z tP:activated T cell apoptosissq~ZɔtP:protein maturationsq~Zt)P:blood vessel endothelial cell migrationsq~Zt)P:positive regulation of neuron apoptosissq~Zt0P:negative regulation of transcription factor...sq~Zt0P:cytoplasmic sequestering of transcription f...sq~Zt0P:positive regulation of transcription factor...sq~Zt0P:DNA damage response, signal transduction by...sq~ZatP:glucose homeostasissq~Zt)P:cellular response to glucose starvationsq~Z*tP:protein refoldingsq~ZtP:sperm chromatin condensationsq~Z~t0P:positive regulation of proteasomal ubiquiti...sq~Z|t0P:regulation of glucocorticoid metabolic processsq~ZtP:innate immune responsesq~Zut0P:positive regulation of nitric oxide biosynt...sq~ZGt&P:negative regulation of cell motilitysq~Z>tP:protein tetramerizationsq~Z&tP:sequestering of metal ionsq~ZǙt*P:negative regulation of helicase activitysq~ZtP:leukocyte migrationsq~Zƍt-P:defense response to Gram-negative bacteriumsq~ZtP:focal adhesion formationsq~Zt0P:insulin-like growth factor receptor signali...sq~Z6t0P:regulation of mitochondrial membrane permea...sq~ZɗtP:defense response to virussq~Zut&P:positive regulation of transcriptionsq~ZDt0P:negative regulation of transcription, DNA-d...sq~Z{,t#P:actin cytoskeleton reorganizationsq~Zzt/P:positive regulation of protein ubiquitinationsq~Z'1tP:response to organic substancesq~Z&>tP:embryonic developmentsq~Z%t$P:anatomical structure morphogenesissq~Z$tP:response to heatsq~Z#t)P:lipopolysaccharide biosynthetic processsq~Z!t%P:caspase activation via cytochrome csq~Z!t0P:induction of apoptosis by extracellular sig...sq~Z!t!P:pyridoxine biosynthetic processsq~Z!`tP:epidermis developmentsq~Z tP:regulation of cell shapesq~Z ^t$P:insulin receptor signaling pathwaysq~Z ]t+P:negative regulation of cell proliferationsq~Z'tP:response to UV-Bsq~Z:tP:protein transportsq~ZytP:neurite developmentsq~Zwst0P:ubiquitin-dependent SMAD protein catabolic ...sq~Zw8t%P:estrogen receptor signaling pathwaysq~Zvdt$P:negative regulation of cell growthsq~Zv tP:platelet formationsq~ZvtP:keratinocyte differentiationsq~Zut*P:protein import into mitochondrial matrixsq~Zu`tP:actin filament-based movementsq~ZFt!P:peptidyl-serine phosphorylationsq~Z?tP:cell-cell adhesionsq~Z?tP:phosphorylationsq~Z>tP:RNA metabolic processsq~Z \t+P:positive regulation of cell proliferationsq~ZtP:protein targetingsq~ZZtP:mitotic anaphasesq~Zt P:cytokinesissq~Z<t,P:protein import into nucleus, translocationsq~ZJt.P:regulation of progression through cell cyclesq~ZMtP:DNA damage checkpointsq~Zzt0P:negative regulation of transcription from R...sq~Zt P:M phasesq~ZtP:protein polyubiquitinationsq~ZtP:activation of MAPKKK activitysq~ZvtP:monocyte differentiationsq~Z.t%P:response to reactive oxygen speciessq~ZptP:fructose metabolic processsq~ZtP:base-excision repairsq~ZtP:nucleotide-excision repairsq~ZtP:L-serine biosynthetic processsq~Zmt)P:membrane protein ectodomain proteolysissq~Zlt P:proteolysissq~ZFt&P:protein amino acid dephosphorylationsq~Z.t(P:regulation of translational initiationsq~ZtP:translational elongationsq~Z tP:translational initiationsq~ZtP:mRNA catabolic processsq~Zt/P:transcription from RNA polymerase II promotersq~ZtP:rRNA processingsq~Zt0P:regulation of transcription from RNA polyme...sq~ZtP:MAPKKK cascadesq~Z5tF:protein bindingsq~Z t F:ATP bindingsq~Z tF:signal transducer activitysq~ZBt*F:protein serine/threonine kinase activitysq~Z@tF:protein kinase activitysq~Zt F:RNA bindingsq~Zt$F:structural constituent of ribosomesq~Zt$F:transcription coactivator activitysq~ZttF:transcription factor activitysq~Z2tF:identical protein bindingsq~ZNJtF:unfolded protein bindingsq~Zet#F:MAP kinase kinase kinase activitysq~Z}tF:protein N-terminus bindingsq~ZtF:transcription factor bindingsq~ZtF:receptor activitysq~ZxtF:TPR domain bindingsq~ZGtF:actin filament bindingsq~Zvt*F:nitric-oxide synthase regulator activitysq~ZPt(F:structural constituent of cytoskeletonsq~Z NtF:zinc ion bindingsq~Z3t#F:protein homodimerization activitysq~Z]t F:DNA bindingsq~Z@t"F:transcription activator activitysq~Z1tF:tRNA bindingsq~Zt F:nitric-oxide synthase activitysq~Zt0F:methylenetetrahydrofolate dehydrogenase act...sq~ZwPtF:Hsp70 protein bindingsq~ZwUt+F:acetylcholine receptor activator activitysq~Z}t0F:methenyltetrahydrofolate cyclohydrolase act...sq~ZwtF:protein binding, bridgingsq~ZMtF:enzyme bindingsq~ZvLtF:estrogen receptor activitysq~ZMtF:protein kinase bindingsq~ZtF:nuclease activitysq~Z t"F:phosphoglycerate kinase activitysq~ZJtF:protein kinase CK2 activitysq~ZǏtF:chaperone bindingsq~ZʧtF:Hsp90 protein bindingsq~Z(t%F:phosphoserine transaminase activitysq~Zut(F:Hsp70/Hsc70 protein inhibitor activitysq~ZUt*F:cyclin-dependent protein kinase activitysq~ZstF:NF-kappaB bindingsq~ZvtF:malic enzyme activitysq~ZđtF:tau-protein kinase activitysq~ZtF:magnesium ion bindingsq~Zt%F:protein heterodimerization activitysq~ZtF:double-stranded RNA bindingsq~ZtF:SMAD bindingsq~ZtF:DNA strand annealing activitysq~Zkt"F:L-lactate dehydrogenase activitysq~ZutF:ErbB-3 class receptor bindingsq~ZtF:microfilament motor activitysq~ZtF:ATPase activity, coupledsq~Zyt0F:RNA polymerase II transcription factor acti...sq~ZTtF:GTPase activitysq~Z t0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~Zt)F:fructose-bisphosphate aldolase activitysq~Zt*F:formate-tetrahydrofolate ligase activitysq~Zt%F:ATP-dependent RNA helicase activitysq~Zt"F:nuclear hormone receptor bindingsq~ZtF:actin bindingsq~Z=tF:phosphate bindingsq~ZtF:protein anchorsq~ZKtF:intermediate filament bindingsq~Zt F:GTP bindingsq~ZtF:calcium ion bindingsq~Zt!F:small GTPase regulator activitysq~ZtF:SH3/SH2 adaptor activitysq~Z"Mt0F:N-acylneuraminate cytidylyltransferase acti...sq~Zt0F:hematopoietin/interferon-class (D200-domain...sq~ZtF:laminin receptor activitysq~Z tF:IkappaB kinase activitysq~Zt#F:ubiquitin-protein ligase activitysq~ZtF:Rho GTPase activator activitysq~Z!t'F:protein kinase CK2 regulator activitysq~ZotF:enzyme activator activitysq~Zt0F:translation factor activity, nucleic acid b...sq~Z -tF:metallopeptidase activitysq~ZtF:copper ion bindingsq~ZNtF:structural molecule activitysq~Z:tF:integrin bindingsq~Z8tF:ErbB-2 class receptor bindingsq~ZtF:receptor bindingsq~ZtF:pyruvate kinase activitysq~Zrt/F:protein serine/threonine phosphatase activitysq~Z;t0F:sodium-dependent phosphate transmembrane tr...sq~ZAtF:ATPase activitysq~Z@t0F:brain-specific angiogenesis inhibitor activitysq~ZCtF:vinculin bindingsq~Zit"F:protein-tyrosine kinase activitysq~Zkt0F:non-membrane spanning protein tyrosine kina...sq~Z`t$F:NF-kappaB-inducing kinase activitysq~Z@t"F:transcription repressor activitysq~Z>tF:cyclosporin A bindingsq~Zit C:cytoplasmsq~Zt C:nucleussq~Z t C:cytosolsq~ZktC:mitochondrionsq~Zt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Zt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Z>t C:membranesq~Zbt C:nucleolussq~ZtC:endoplasmic reticulumsq~Zt C:nucleoplasmsq~ZtC:protein complexsq~Z%tC:focal adhesionsq~Z>tC:integral to membranesq~ZtC:plasma membranesq~ZtC:integral to plasma membranesq~Z= tC:actin cytoskeletonsq~ZtC:nuclear envelopesq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZtC:Golgi membranesq~ZtC:cytoskeletonsq~Z#tC:transcription factor complexsq~Zt"C:muscle thin filament tropomyosinsq~ZWt!C:perinuclear region of cytoplasmsq~Zt0C:proteasome regulatory particle (sensu Eukar...sq~ZtC:spindle microtubulesq~ZmtC:mitochondrial outer membranesq~Zt0C:eukaryotic translation initiation factor 3 ...sq~ZtC:contractile ringsq~ZDtC:protein kinase CK2 complexsq~ZtC:insoluble fractionsq~ZtC:condensed nuclear chromosomesq~Z{jtC:neuromuscular junctionsq~Zzt&C:ubiquitin conjugating enzyme complexsq~ZytC:pseudopodiumsq~Z'tC:cell surfacesq~Zvt C:growth conesq~Zvt C:dendritesq~ZvtC:axonsq~Z?tC:nuclear matrixsq~Z@tC:SWI/SNF complexsq~ZutC:COPI vesicle coatsq~Zuit C:desmosomesq~Z}tC:cleavage furrowsq~ZtC:Bcl3/NF-kappaB2 complexsq~ZtC:soluble fractionsq~ZtC:spindle polesq~ZtC:stress fibersq~ZtC:cytoplasmic partsq~ZtC:rufflesq~ZtC:membrane fractionsq~ZtC:intracellularsq~ZtC:extracellular regionsq~Zt0C:eukaryotic translation elongation factor 1 ...sq~Zt C:cell somasq~Zt C:spectrinsq~Z@tC:chromatin remodeling complexppppppppppppppppppxsq~uq~ sq~t0P:positive regulation of nitric oxide biosynt...t45429sq~tP:response to unfolded proteint6986sq~t*F:nitric-oxide synthase regulator activityt30235sq~tF:TPR domain bindingt30911sq~t C:cytoplasmt5737pppppxsq~uq~ sq~t IPR003594t ATP_bd_ATPasesq~t IPR001404tHsp90ppppppppxsq~uq~ sq~t HATPase_ctPF02518sq~tHSP90tPF00183ppppppppxtP08238t HS90B_HUMANsq~uq~ sq~tHSP 84sq~tHSP 90ppppppppxt Homo sapienstREREsq~P?`jcc%t0Arginine-glutamic acid dipeptide repeats proteinsq~uq~ sq~UctENSG00000142599pppppppppxsq~uq~ sq~mctREREsq~mctARGsq~mctARPsq~mctATN1Lsq~mctKIAA0458pppppxsq~-uq~ Psq~Z@act&P:negative regulation of transcriptionsq~Zct,P:regulation of transcription, DNA-dependentsq~Zsct0P:positive regulation of I-kappaB kinase/NF-k...sq~ZctP:cell motilitysq~Z+ctP:immune responsesq~Zct$P:central nervous system developmentsq~Z!ct.P:release of cytoplasmic sequestered NF-kappaBsq~Z&ctP:organ morphogenesissq~Z>ctP:RNA metabolic processsq~ZctP:visual perceptionsq~Z@ctP:histone acetylationsq~ZBctP:phospholipid scramblingsq~ZctP:focal adhesion formationsq~ZuctP:myeloid cell differentiationsq~ZuctP:platelet activationsq~Zuct0P:negative regulation of Wnt receptor signali...sq~Zvct'P:positive regulation of cell migrationsq~Zct"P:regulation of cell proliferationsq~Zuct&P:positive regulation of transcriptionsq~ZtctP:DNA replicationsq~Z%ctP:response to virussq~Zw8ct%P:estrogen receptor signaling pathwaysq~Z ctF:protein bindingsq~ZctF:signal transducer activitysq~ZctF:transcription factor bindingsq~Zct$F:transcription corepressor activitysq~ZMctF:kinase bindingsq~Z2ct$F:histone acetyltransferase activitysq~Zct F:RNA bindingsq~Z6ct*F:H3/H4 histone acetyltransferase activitysq~ZtctF:transcription factor activitysq~ZctF:calcium ion bindingsq~Zvct"F:thyroid hormone receptor bindingsq~Zct F:interleukin-1 receptor bindingsq~ZBct"F:phospholipid scramblase activitysq~ZPct(F:structural constituent of cytoskeletonsq~ZQct-F:extracellular matrix structural constituentsq~Zct C:nucleussq~Zct$C:proteinaceous extracellular matrixsq~Zict C:cytoplasmsq~ZctC:intermediate filamentsq~ZctC:basement membranesq~ZctC:plasma membranesq~Zct&C:proteasome complex (sensu Eukaryota)sq~Z%ctC:focal adhesionpppppppppppppppppppppppppppppppppppxsq~uq~ sq~ct+P:NLS-bearing substrate import into nucleust6607sq~ctF:poly-glutamine tract bindingt8267sq~ct C:nucleust5634pppppppxsq~uq~ sq~ct IPR002951tAtrophinsq~ct IPR001025tBAHsq~ct IPR000949tELM2sq~ct IPR014778t Myb_DNA-bdsq~ct IPR001005t SANT_DNA-bdsq~ct IPR000679tZnf_GATAppppxsq~uq~ sq~ct Atrophin-1tPF03154sq~ctBAHtPF01426sq~ctELM2tPF01448sq~ctGATAtPF00320sq~ctMyb_DNA-bindingtPF00249pppppxtQ9P2R6t RERE_HUMANsq~uq~ sq~ctAtrophin-1-like proteinsq~ctAtrophin-1-related proteinppppppppxt Homo sapienstFBX11sq~P?|$ F %tF-box only protein 11sq~uq~ sq~UFtENSG00000138081pppppppppxsq~uq~ sq~mFtFBXO11sq~mFtFBX11sq~mFtVIT1pppppppxsq~;uq~ Psq~Z [FtP:cell proliferationsq~ZoFt/P:ubiquitin-dependent protein catabolic processsq~ZFt P:glycolysissq~ZFtP:base-excision repairsq~ZFtP:nucleotide-excision repairsq~ZFt,P:regulation of transcription, DNA-dependentsq~Z9FtP:protein foldingsq~Z@FtP:protein modification processsq~ZFtP:caspase activationsq~Z!Ft%P:caspase activation via cytochrome csq~ZJFtP:response to unfolded proteinsq~ZFtP:cell cycle arrestsq~ZFtP:signal transductionsq~ZFt0P:cell surface receptor linked signal transdu...sq~ZkFt&P:multicellular organismal developmentsq~ZFt P:cell agingsq~ZFtP:protein localizationsq~Z%Ft$P:anatomical structure morphogenesissq~Z:Ft"P:negative regulation of apoptosissq~Z>FtP:protein tetramerizationsq~ZFtP:cell redox homeostasissq~ZGFtP:ER overload responsesq~ZFt%P:regulation of macrophage activationsq~ZFt0P:DNA damage response, signal transduction by...sq~ZFt)P:cellular response to glucose starvationsq~ZvdFt$P:negative regulation of cell growthsq~ZFt$P:prostaglandin biosynthetic processsq~Z6Ft0P:regulation of mitochondrial membrane permea...sq~ZǙFt*P:negative regulation of helicase activitysq~ZFtF:protein bindingsq~Z:Ft+F:protein disulfide oxidoreductase activitysq~ZǏFtF:chaperone bindingsq~ZNJFtF:unfolded protein bindingsq~Z}FtF:protein N-terminus bindingsq~ZFt%F:protein heterodimerization activitysq~ZMFtF:enzyme bindingsq~Z#_FtF:electron carrier activitysq~ZWFt F:NAD bindingsq~Z NFtF:zinc ion bindingsq~ZFtF:copper ion bindingsq~ZFtF:cytokine activitysq~ZFt%F:GDP-dissociation inhibitor activitysq~ZFtF:nuclease activitysq~Z Ft0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZOFtF:endopeptidase activitysq~ZFt F:RNA bindingsq~ZtFtF:transcription factor activitysq~ZFt F:ATP bindingsq~ZFtF:DNA strand annealing activitysq~ZFtF:transketolase activitysq~ZkFtC:mitochondrionsq~ZFtC:insoluble fractionsq~ZFt+C:proteasome core complex (sensu Eukaryota)sq~ZiFt C:cytoplasmsq~Z?FtC:nuclear matrixsq~ZbFt C:nucleolussq~ZFt C:nucleoplasmsq~ZFt C:nucleussq~ZFtC:extracellular regionpppppppppppppppppppppxsq~uq~ sq~FtP:protein ubiquitinationt16567sq~Ft/P:ubiquitin-dependent protein catabolic processt6511sq~FtF:protein bindingt5515sq~Ft#F:ubiquitin-protein ligase activityt4842sq~FtC:ubiquitin ligase complext151pppppxsq~uq~ sq~Ft IPR006633tCASHsq~Ft IPR001810tF-boxsq~Ft IPR006626tPbH1sq~Ft IPR003126tZnf_N-recogninppppppxsq~uq~ sq~FtF-boxtPF00646sq~Ftzf-UBRtPF02207ppppppppxtQ86XK2t FBX11_HUMANsq~uq~ sq~FtVitiligo-associated protein 1sq~FtVIT-1ppppppppxt Homo sapienstGRIP1sq~P?{%t(Glutamate receptor-interacting protein 1sq~uq~ sq~U{tENSG00000155974pppppppppxsq~uq~ sq~m{tGRIP1pppppppppxsq~;uq~ Psq~Z{tP:signal transductionsq~Zc{tP:cell-cell signalingsq~Z{t/P:transcription from RNA polymerase II promotersq~Zd{tP:synaptic transmissionsq~ZE{t0P:positive regulation of transcription, DNA-d...sq~Zw9{t%P:androgen receptor signaling pathwaysq~Z{t0P:negative regulation of adenylate cyclase ac...sq~Z{t0P:G-protein coupled receptor protein signalin...sq~Z{tP:cell adhesionsq~Z{tP:muscle contractionsq~Z{t P:transportsq~ZD{t$P:protein amino acid phosphorylationsq~Z{t,P:regulation of transcription, DNA-dependentsq~Zw8{t%P:estrogen receptor signaling pathwaysq~ZJ{t!P:intracellular signaling cascadesq~Z|{tP:sex differentiationsq~Z>{t P:cell growthsq~Zx{tP:prostate gland developmentsq~Z{tP:transcription, DNA-dependentsq~Z%{t$P:anatomical structure morphogenesissq~Z [{tP:cell proliferationsq~Z{tP:female pregnancysq~Z}{tF:protein N-terminus bindingsq~Z{tF:androgen receptor bindingsq~Z{tF:ephrin receptor bindingsq~Z{t$F:transcription coactivator activitysq~Z{tF:protein bindingsq~Zt{tF:transcription factor activitysq~Z{t"F:glucocorticoid receptor activitysq~Z{tF:androgen receptor activitysq~ZB{t*F:protein serine/threonine kinase activitysq~Z;{t/F:kainate selective glutamate receptor activitysq~Z2{t$F:histone acetyltransferase activitysq~Z{tF:actin bindingsq~Z{t!F:transcription cofactor activitysq~Zv{t*F:nitric-oxide synthase regulator activitysq~ZvL{tF:estrogen receptor activitysq~Z L{t0F:receptor signaling protein tyrosine kinase ...sq~Z{t F:neuropeptide receptor activitysq~Z{t0F:metabotropic glutamate, GABA-B-like recepto...sq~Z{t F:ATP bindingsq~Z{tF:protein dimerization activitysq~Zv{t"F:thyroid hormone receptor bindingsq~Zv{t0F:RNA polymerase II transcription factor acti...sq~Zy{tF:androgen bindingsq~Z{t0F:receptor signaling protein tyrosine phospha...sq~Zk{t0F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole ...sq~Z{tC:integral to plasma membranesq~Z{t C:nucleussq~Z{t C:synapsesq~Z@{tC:chromatin remodeling complexsq~Z'{tC:cell surfacesq~Z{t&C:proteasome complex (sensu Eukaryota)sq~Z{tC:intracellularsq~Z{tC:soluble fractionsq~Zi{t C:cytoplasmsq~Z{tC:mitochondrial matrixsq~Z{tC:plasma membranesq~Z>{t C:membranepppppppppppppppppppppxsq~uq~ sq~{t%P:androgen receptor signaling pathwayt30521sq~{t0P:positive regulation of transcription, DNA-d...t45893sq~{tF:androgen receptor bindingt50681sq~{t.F:receptor signaling complex scaffold activityt30159sq~{t$F:transcription coactivator activityt3713pppppxsq~uq~ sq~{t IPR001478tPDZpppppppppxsq~uq~ sq~{tPDZtPF00595pppppppppxtQ9Y3R0t GRIP1_HUMANsq~uq~ sq~{t GRIP1 proteinpppppppppxt Homo sapienstEZH2sq~P?D8E1$%tEnhancer of zeste homolog 2sq~uq~ sq~U1$tENSG00000106462pppppppppxsq~uq~ sq~m1$tEZH2pppppppppxsq~_uq~ sq~Z1$tP:DNA methylationsq~ZGg1$t0P:protein amino acid N-linked glycosylation v...sq~Z1$t,P:regulation of transcription, DNA-dependentsq~Z1$tP:anti-apoptosissq~ZY1$t0P:chromosome organization and biogenesis (sen...sq~Z1$tP:cell cycle arrestsq~Z1$tP:signal transductionsq~Z1$t0P:G-protein coupled receptor protein signalin...sq~ZJ1$t!P:intracellular signaling cascadesq~Zk1$t&P:multicellular organismal developmentsq~ZG1$tP:ER overload responsesq~Z 1$tP:activated T cell apoptosissq~ZǙ1$t*P:negative regulation of helicase activitysq~Z1$tP:cation transportsq~Z1$t#P:nitric oxide biosynthetic processsq~Z1$tP:polyamine metabolic processsq~Z1$tP:methionine metabolic processsq~Zo1$t/P:ubiquitin-dependent protein catabolic processsq~Z91$tP:protein foldingsq~Z1$t P:cell agingsq~Z1$tP:protein localizationsq~Z [1$tP:cell proliferationsq~Z1$t0P:insulin-like growth factor receptor signali...sq~Z61$t0P:regulation of mitochondrial membrane permea...sq~Z1$t(P:protein amino acid autophosphorylationsq~Z-1$t0P:tRNA transcription from RNA polymerase III ...sq~Z'1$tP:5S class rRNA transcriptionsq~Z1$t0P:DNA damage response, signal transduction by...sq~Zw1$t#P:cellular hydrogen ion homeostasissq~Zvm1$tP:sperm motilitysq~Zvd1$t$P:negative regulation of cell growthsq~ZF1$t!P:peptidyl-serine phosphorylationsq~Z@1$tP:chromatin modificationsq~Z>1$tP:protein tetramerizationsq~Z@a1$t&P:negative regulation of transcriptionsq~Z$1$tP:response to heatsq~Z!1$t%P:caspase activation via cytochrome csq~Z ^1$t$P:insulin receptor signaling pathwaysq~Z ]1$t+P:negative regulation of cell proliferationsq~Z1$tP:chromatin remodelingsq~Z1$tP:DNA recombinationsq~Z1$tP:nucleotide-excision repairsq~Z1$tP:base-excision repairsq~Z1$t P:DNA repairsq~Zt1$tP:DNA replicationsq~Z<1$t,P:protein import into nucleus, translocationsq~Z1$t)P:cellular response to glucose starvationsq~Zz1$t0P:negative regulation of transcription from R...sq~Z 1$tF:protein bindingsq~Zt1$tF:transcription factor activitysq~Z1$t F:ATP bindingsq~Z21$tF:identical protein bindingsq~ZM1$tF:enzyme bindingsq~Z.1$t.F:DNA (cytosine-5-)-methyltransferase activitysq~Z1$t$F:transcription coactivator activitysq~Z1$tF:nuclease activitysq~ZA1$tF:isomerase activitysq~ZO1$tF:endopeptidase activitysq~Z71$tF:histone deacetylase activitysq~Z|1$t!F:retinoic acid receptor activitysq~Z^1$tF:DNA helicase activitysq~ZF1$t$F:histone methyltransferase activitysq~Z]1$t F:DNA bindingsq~Z1$tF:DNA strand annealing activitysq~Z1$t%F:protein heterodimerization activitysq~Z}1$tF:protein N-terminus bindingsq~Z=.1$t0F:ATPase activity, coupled to transmembrane m...sq~Z1$t0F:dolichyl-diphosphooligosaccharide-protein g...sq~ZB1$t*F:protein serine/threonine kinase activitysq~Z@1$t"F:transcription repressor activitysq~Z1$tF:transcription factor bindingsq~Z N1$tF:zinc ion bindingsq~Z1$tF:copper ion bindingsq~Z1$t-F:sodium:potassium-exchanging ATPase activitysq~Z1$tF:spermidine synthase activitysq~Z 1$t0F:site-specific DNA-methyltransferase (cytosi...sq~Z1$t C:nucleussq~Zi1$t C:cytoplasmsq~Z?1$tC:nuclear matrixsq~Z :1$t$C:oligosaccharyl transferase complexsq~Zv1$tC:histone deacetylase complexsq~Z1$t,C:sodium:potassium-exchanging ATPase complexsq~Z1$t+C:proteasome core complex (sensu Eukaryota)sq~Z1$tC:mitochondrial matrixsq~Z1$tC:plasma membranesq~Zk1$tC:mitochondrionsq~Z1$t C:euchromatinsq~Zb1$t C:nucleolussq~ZX1$tC:nuclear heterochromatinsq~Z1$t C:nucleoplasmsq~Z1$tC:ESC/E(Z) complexsq~Z1$tC:insoluble fractionsq~Z1$tC:membrane fractionsq~Z>1$t C:membranesq~Z1$t%C:transcription factor TFIIIC complexpppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~1$t0P:establishment and/or maintenance of chromat...t6325sq~1$t,P:regulation of transcription, DNA-dependentt6355sq~1$t F:DNA bindingt3677sq~1$t$F:histone methyltransferase activityt42054sq~1$tF:protein bindingt5515sq~1$tC:ESC/E(Z) complext35098ppppxsq~uq~ sq~1$t IPR001005t SANT_DNA-bdsq~1$t IPR001214tSETppppppppxsq~uq~ sq~1$tSETtPF00856pppppppppxtQ15910t EZH2_HUMANsq~uq~ sq~1$tENX-1pppppppppxt Homo sapienstPSD13sq~P?̜#t#%t/26S proteasome non-ATPase regulatory subunit 13sq~uq~ sq~UttENSG00000185627pppppppppxsq~uq~ sq~mttPSMD13pppppppppxsq~Luq~ Psq~Zott/P:ubiquitin-dependent protein catabolic processsq~ZttP:signal transductionsq~ZDtt$P:protein amino acid phosphorylationsq~Zltt P:proteolysissq~Z&ttP:response to stresssq~ZƤtt#P:T cell receptor signaling pathwaysq~Ztt0P:establishment and/or maintenance of cell po...sq~ZttP:induction of apoptosissq~ZQtt#P:I-kappaB kinase/NF-kappaB cascadesq~ZttP:anti-apoptosissq~Zƶtt*P:positive regulation of T cell activationsq~ZnttP:ATP-dependent proteolysissq~ZEtt0P:negative regulation of protein kinase activitysq~Zstt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z.tt(P:regulation of translational initiationsq~Ztt/P:transcription from RNA polymerase II promotersq~ZRtt)P:activation of NF-kappaB-inducing kinasesq~ZVtt P:JNK cascadesq~ZcttP:cell-cell signalingsq~ZƅttP:protein stabilizationsq~Ztt(P:protein amino acid autophosphorylationsq~Z=tt$P:tetrahydrofolate metabolic processsq~Ztt-P:positive regulation of cell differentiationsq~Ztt0P:positive regulation of gene-specific transc...sq~Ztt0P:proteasomal ubiquitin-dependent protein cat...sq~Z=tt.P:negative regulation of programmed cell deathsq~Z@ttP:protein ubiquitinationsq~Z=ttP:glutamate transportsq~Z=ttP:glucose transportsq~Z ]tt+P:negative regulation of cell proliferationsq~Z [ttP:cell proliferationsq~Zktt&P:multicellular organismal developmentsq~Ztt,P:regulation of transcription, DNA-dependentsq~Zztt0P:negative regulation of transcription from R...sq~ZttP:protein polyubiquitinationsq~Z tt0P:positive regulation of T cell cytokine prod...sq~ZttP:cell morphogenesissq~ZJtt.P:regulation of progression through cell cyclesq~ZttF:protein bindingsq~ZAttF:ATPase activitysq~ZttF:signal transducer activitysq~ZBtt*F:protein serine/threonine kinase activitysq~Ztt$F:transcription coactivator activitysq~Ztt F:RNA bindingsq~Ztt$F:transcription corepressor activitysq~ZOttF:endopeptidase activitysq~Ztt!F:transcription cofactor activitysq~Ztt#F:ubiquitin-protein ligase activitysq~ZwttF:protein binding, bridgingsq~Z{+tt0F:thyrotropin-releasing hormone receptor bindingsq~Z=ttF:phosphate bindingsq~Z2ttF:identical protein bindingsq~ZtttF:transcription factor activitysq~ZttF:magnesium ion bindingsq~Z}tt0F:methenyltetrahydrofolate cyclohydrolase act...sq~Ztt0F:methylenetetrahydrofolate dehydrogenase (NA...sq~Ztt F:ATP bindingsq~Z;ttF:hormone activitysq~Z tt!F:growth hormone receptor bindingsq~ZttF:receptor activitysq~Ztt0F:L-glutamate transmembrane transporter activitysq~ZttF:transcription factor bindingsq~Ztt0F:methylenetetrahydrofolate dehydrogenase (NA...sq~Zitt"F:protein-tyrosine kinase activitysq~Ztt&C:proteasome complex (sensu Eukaryota)sq~Ztt C:nucleussq~Ztt0C:proteasome regulatory particle (sensu Eukar...sq~Zitt C:cytoplasmsq~ZkttC:mitochondrionsq~Ztt C:polysomesq~Ztt C:cytosolsq~ZttC:cytoplasmic partsq~ZttC:endoplasmic reticulumsq~Ztt+C:proteasome core complex (sensu Eukaryota)sq~ZttC:Bcl3/NF-kappaB2 complexsq~ZottC:mitochondrial inner membraneppppxsq~uq~ sq~ttF:protein bindingt5515sq~tt0C:proteasome regulatory particle (sensu Eukar...t5838ppppppppxsq~uq~ sq~tt IPR000717tPCIpppppppppxsq~uq~ sq~ttPCItPF01399pppppppppxtQ9UNM6t PSD13_HUMANsq~uq~ sq~tt%26S proteasome regulatory subunit S11sq~tt'26S proteasome regulatory subunit p40.5ppppppppxt Homo sapienstTMBI4sq~P?`!Bz s %t6Transmembrane BAX inhibitor motif-containing protein 4sq~uq~ sq~UstENSG00000155957pppppppppxsq~uq~ sq~mstTMBIM4sq~mstCGI-119ppppppppxsq~=uq~ Psq~ZGgst0P:protein amino acid N-linked glycosylation v...sq~ZstP:cell redox homeostasissq~Zst0P:cell surface receptor linked signal transdu...sq~ZstP:signal transductionsq~Zst-P:mitotic spindle organization and biogenesissq~ZVst.P:nuclear membrane organization and biogenesissq~ZstP:nuclear migrationsq~Zst0P:generation of precursor metabolites and energysq~Zst0P:mitochondrial electron transport, NADH to u...sq~Zst0P:nucleobase, nucleoside, nucleotide and nucl...sq~Zst$P:DNA fragmentation during apoptosissq~ZstP:RNA processingsq~Z st P:translationsq~Zst P:apoptosissq~ZstP:lipid metabolic processsq~ZstP:ceramide metabolic processsq~ZQst#P:I-kappaB kinase/NF-kappaB cascadesq~ZYstP:activation of JNK activitysq~Z`st+P:small GTPase mediated signal transductionsq~Zust P:sphingolipid catabolic processsq~Z>$stP:fatty acid transportsq~ZOst P:protein amino acid methylationsq~Zst!P:intracellular protein transportsq~ZstF:protein bindingsq~Z#_stF:electron carrier activitysq~Z!stF:cytochrome-c oxidase activitysq~Z2stF:identical protein bindingsq~ZQstF:microtubule bindingsq~Zst+F:sphinganine-1-phosphate aldolase activitysq~Z;st!F:fatty acid transporter activitysq~Zst*F:NADH dehydrogenase (ubiquinone) activitysq~ZstF:N-methyltransferase activitysq~Z st"F:phosphatidylethanolamine bindingsq~Z:st+F:protein disulfide oxidoreductase activitysq~ZNJstF:unfolded protein bindingsq~ZstF:calcium ion bindingsq~ZstF:Ran GTPase activator activitysq~ZstF:GTPase activator activitysq~Zst.F:caspase-activated deoxyribonuclease activitysq~ZTstF:GTPase activitysq~Zst.F:peptidyl-prolyl cis-trans isomerase activitysq~Zst$F:structural constituent of ribosomesq~Zst F:RNA bindingsq~ZstF:enzyme inhibitor activitysq~Zist C:cytoplasmsq~Zst C:nucleussq~Z :st$C:oligosaccharyl transferase complexsq~Z>stC:integral to membranesq~Zst C:cytosolsq~Zst C:endoplasmic reticulum membranesq~ZwBst0C:heterogeneous nuclear ribonucleoprotein com...sq~Zust,C:integral to endoplasmic reticulum membranesq~Zst C:ribosomesq~ZstC:endoplasmic reticulum lumensq~Zst&C:proteasome complex (sensu Eukaryota)sq~ZstC:translocon complexsq~Zsst+C:mitochondrial respiratory chain complex Isq~Zst C:nucleoplasmsq~Z stC:nuclear poresq~ZstC:nuclear envelopesq~ZstC:soluble fractionpppppppppppppppppppxsq~uq~ sq~stF:protein bindingt5515pppppppppxsq~uq~ sq~st IPR006214tUPF0005pppppppppxsq~uq~ sq~stUPF0005tPF01027pppppppppxtQ9HC24t TMBI4_HUMANsq~uq~ sq~st Z-proteinsq~st Protein S1Rppppppppxt Homo sapienstPSD12sq~P?oo t %t/26S proteasome non-ATPase regulatory subunit 12sq~uq~ sq~UttENSG00000197170pppppppppxsq~uq~ sq~mttPSMD12pppppppppxsq~-uq~ Psq~Zstt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZRtt)P:activation of NF-kappaB-inducing kinasesq~ZttP:cell adhesionsq~Z+ttP:immune responsesq~ZƤtt#P:T cell receptor signaling pathwaysq~Zott/P:ubiquitin-dependent protein catabolic processsq~ZnttP:ATP-dependent proteolysissq~ZDtt$P:protein amino acid phosphorylationsq~Ztt/P:transcription from RNA polymerase II promotersq~Z ]tt+P:negative regulation of cell proliferationsq~Z#tt.P:nucleoside triphosphate biosynthetic processsq~Z=ttP:glucose transportsq~Zƶtt*P:positive regulation of T cell activationsq~Z:tt"P:negative regulation of apoptosissq~Z=tt.P:negative regulation of programmed cell deathsq~Ztt0P:proteasomal ubiquitin-dependent protein cat...sq~Z2tt0P:positive regulation of keratinocyte differe...sq~Zrtt%P:regulation of epidermis developmentsq~Ztt0P:positive regulation of epithelial cell prol...sq~Ztt,P:regulation of transcription, DNA-dependentsq~ZttP:protein polyubiquitinationsq~ZttP:signal transductionsq~Z tt0P:positive regulation of T cell cytokine prod...sq~Ztt0P:positive regulation of gene-specific transc...sq~Z ttF:protein bindingsq~ZAttF:ATPase activitysq~Ztt F:ATP bindingsq~ZOttF:endopeptidase activitysq~Ztt F:RNA bindingsq~ZtttF:transcription factor activitysq~Ztt!F:transcription cofactor activitysq~Ztt(F:nucleoside diphosphate kinase activitysq~Z{+tt0F:thyrotropin-releasing hormone receptor bindingsq~Z;ttF:hormone activitysq~Z`tt$F:NF-kappaB-inducing kinase activitysq~Ztt#F:ubiquitin-protein ligase activitysq~ZttF:signal transducer activitysq~Z tt!F:growth hormone receptor bindingsq~Ztt0C:proteasome regulatory particle (sensu Eukar...sq~Ztt&C:proteasome complex (sensu Eukaryota)sq~Zitt C:cytoplasmsq~Ztt C:nucleussq~ZttC:rufflesq~ZuKttC:lamellipodiumsq~Ztt+C:proteasome core complex (sensu Eukaryota)pppppppppppppppppppppppppppppppppppxsq~uq~ sq~ttF:protein bindingt5515sq~tt0C:proteasome regulatory particle (sensu Eukar...t5838ppppppppxsq~uq~ sq~tt IPR000717tPCIsq~tt IPR011991tWing_hlx_DNA_bdppppppppxsq~uq~ sq~ttPCItPF01399pppppppppxtO00232t PSD12_HUMANsq~uq~ sq~tt%26S proteasome regulatory subunit p55pppppppppxt Homo sapienstRRMJ1sq~P?2_t,_%t*Putative ribosomal RNA methyltransferase 1sq~uq~ sq~Ut,tENSG00000068438pppppppppxsq~uq~ sq~mt,tFTSJ1sq~mt,tJM23ppppppppxsq~uq~ @sq~Z [t,tP:cell proliferationsq~Ztt,tP:DNA replicationsq~Zt,tP:signal transductionsq~Z t,t P:translationsq~Zot,t/P:ubiquitin-dependent protein catabolic processsq~Zt,tP:mRNA processingsq~Zt,tP:rRNA processingsq~Zt,tP:induction of apoptosissq~Z9t,tP:protein foldingsq~Z=t,tP:protein complex assemblysq~ZCt,tP:response to oxidative stresssq~Zt,t$P:prostaglandin biosynthetic processsq~Z`t,t+P:small GTPase mediated signal transductionsq~ZJt,t.P:regulation of progression through cell cyclesq~Z ]t,t+P:negative regulation of cell proliferationsq~Z>t,t P:cell growthsq~Z t,tP:RNA splicingsq~Zt,t0P:cell surface receptor linked signal transdu...sq~Zt,tP:mRNA polyadenylationsq~Z#t,t.P:ribonucleoside diphosphate catabolic processsq~Z t,tP:translational initiationsq~Z%t,t$P:anatomical structure morphogenesissq~Zt,tP:regulation of translationsq~Zt,t-P:tRNA aminoacylation for protein translationsq~Z%t,tP:tyrosyl-tRNA aminoacylationsq~Z.t,t(P:regulation of translational initiationsq~Zt,tP:chromatin remodelingsq~Zt,t0P:regulation of transcription from RNA polyme...sq~Z \t,t+P:positive regulation of cell proliferationsq~Zt,tP:regulation of mitosissq~Zt,t(P:purine nucleotide biosynthetic processsq~Zt,tP:purine ribonucleoside salvagesq~Z!t,t%P:caspase activation via cytochrome csq~Zt,t P:DNA repairsq~Zt,tP:nucleosome assemblysq~Z#t,t"P:purine base biosynthetic processsq~Zt,tP:transcriptionsq~Zt,t,P:regulation of transcription, DNA-dependentsq~Zt,tP:regulation of DNA replicationsq~Z@t,tP:protein modification processsq~Zt,t"P:regulation of muscle contractionsq~Z&t,tP:response to stresssq~Z*t,tP:inflammatory responsesq~ZJt,tP:response to unfolded proteinsq~Zbt,t*P:cytoskeleton organization and biogenesissq~Zt,t P:cell cyclesq~Zt,tP:cell cycle arrestsq~Zat,tP:tRNA processingsq~Zt,t P:behaviorsq~ZKt,tP:protein kinase cascadesq~Zkt,t&P:multicellular organismal developmentsq~Zst,tP:spermatogenesissq~Zt,t P:chemotaxissq~Zt,tP:caspase activationsq~Zt,t P:apoptosissq~ZFt,t&P:protein amino acid dephosphorylationsq~ZOt,t P:protein amino acid methylationsq~Zlt,t P:proteolysissq~Zt,tP:glutamate metabolic processsq~Zt,tP:methionine metabolic processsq~Zt,tP:polyamine metabolic processsq~Zt,t#P:snRNP protein import into nucleussq~Zt,tP:lipid metabolic processsq~Zt,tP:fatty acid beta-oxidationsq~Zt,tP:ceramide metabolic processsq~Z't,t"P:cholesterol biosynthetic processsq~Z^t,t"P:glutathione biosynthetic processsq~Z]t,tP:muscle developmentsq~Zt,t%P:regulation of macrophage activationsq~Zut,t.P:regulation of Wnt receptor signaling pathwaysq~Zt,tP:telomere maintenancesq~Zut,tP:regulation of cell adhesionsq~Zut,tP:neuron differentiationsq~Zct,t'P:plasma membrane to endosome transportsq~Zvdt,t$P:negative regulation of cell growthsq~Zt,tP:cellular respirationsq~Zt,t%P:phosphoinositide-mediated signalingsq~Zt,t P:hypoxanthine metabolic processsq~Zt,t0P:positive regulation of dopamine metabolic p...sq~Zt,t$P:regulation of cell differentiationsq~ZDt,t$P:protein amino acid phosphorylationsq~Zt,tP:regulation of transcriptionsq~Zt,tP:histone exchangesq~Zt,tP:response to drugsq~Zst,t0P:positive regulation of I-kappaB kinase/NF-k...sq~Z:t,t"P:negative regulation of apoptosissq~Zt,t$P:DNA fragmentation during apoptosissq~ZMt,t%P:second-messenger-mediated signalingsq~Z'1t,tP:response to organic substancesq~ZOt,t0P:regulation of cyclin-dependent protein kina...sq~ZYt,tP:protein homotetramerizationsq~Zt,tP:inactivation of MAPK activitysq~Zt,t)P:nuclear mRNA 3'-splice site recognitionsq~Z@at,t&P:negative regulation of transcriptionsq~Zt,t0P:negative regulation of tyrosine phosphoryla...sq~Z?Jt,t+P:regulation of striated muscle developmentsq~ZGt,t0P:peptidyl-proline hydroxylation to 4-hydroxy...sq~Zt,tP:skeletal developmentsq~Z>xt,tP:proton transportsq~Z t,tP:blastocyst developmentsq~ZIt,t!P:actin filament bundle formationsq~Zt,t!P:regulation of blood vessel sizesq~Zt,tP:cell motilitysq~ZKgt,tP:D-ribose catabolic processsq~ZKt,tP:cell cycle checkpointsq~Z0t,tF:protein bindingsq~Z t,t F:RNA bindingsq~Zt,t$F:structural constituent of ribosomesq~ZNJt,tF:unfolded protein bindingsq~Z2t,tF:identical protein bindingsq~ZAt,tF:ATPase activitysq~Zt,tF:signal transducer activitysq~Zt,t%F:GDP-dissociation inhibitor activitysq~Z_t,tF:transporter activitysq~Zt,tF:magnesium ion bindingsq~Zt,tF:cytokine activitysq~Zt,tF:nucleotide bindingsq~Z!t,t0F:protein phosphatase type 2A regulator activitysq~ZǏt,tF:chaperone bindingsq~Z Nt,tF:zinc ion bindingsq~Zut,tF:ADP reductase activitysq~ZJt,t"F:ADP-sugar diphosphatase activitysq~Z@t,t-F:specific transcriptional repressor activitysq~Z3t,t#F:protein homodimerization activitysq~Z t,t"F:phosphatidylethanolamine bindingsq~Z!Xt,tF:Ran GTPase bindingsq~Z?Pt,t F:AMP bindingsq~Z#_t,tF:electron carrier activitysq~Z +t,tF:metalloexopeptidase activitysq~Zt,tF:N-methyltransferase activitysq~Zt,tF:transcription factor bindingsq~Zʧt,tF:Hsp90 protein bindingsq~Zt,t0F:glutamate-cysteine ligase catalytic subunit...sq~Zct,t0F:electron transporter, transferring electron...sq~Z~t,tF:MutLalpha complex bindingsq~Zyt,t0F:RNA splicing factor activity, transesterifi...sq~Zwt,tF:protein binding, bridgingsq~Zt,t%F:protein heterodimerization activitysq~Zv{t,tF:estrogen receptor bindingsq~Zut,tF:chaperone activator activitysq~ZNEt,tF:heme bindingsq~ZMt,tF:syntaxin bindingsq~Zt,t0F:translation factor activity, nucleic acid b...sq~Z,t,t#F:prostaglandin-E synthase activitysq~Z!t,t F:interleukin-8 receptor bindingsq~ZFt,t0F:hypoxanthine phosphoribosyltransferase acti...sq~Zt,tF:phospholipase D activitysq~Zt,t0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~Z0t,t,F:procollagen-proline 4-dioxygenase activitysq~ZBt,t*F:protein serine/threonine kinase activitysq~Zt,t/F:ribonucleoside-diphosphate reductase activitysq~Zt,tF:serine-tRNA ligase activitysq~Zt,tF:spermidine synthase activitysq~Zt,tF:transketolase activitysq~Zt,tF:tyrosine-tRNA ligase activitysq~Zt,t"F:phospholipase inhibitor activitysq~Zt,t0F:cyclin-dependent protein kinase inhibitor a...sq~Zt,tF:receptor bindingsq~Zt,t F:GTP bindingsq~Zt,t F:ATP bindingsq~Zpt,t F:bindingsq~Zt,tF:enoyl-CoA hydratase activitysq~ZOt,tF:endopeptidase activitysq~Zt,t,F:adenine phosphoribosyltransferase activitysq~Zt,tF:ATPase activator activitysq~Z^t,tF:DNA helicase activitysq~Ztt,tF:transcription factor activitysq~Zt,tF:telomerase activitysq~Zt,t.F:peptidyl-prolyl cis-trans isomerase activitysq~Zt,tF:mRNA bindingsq~Z1t,tF:tRNA bindingsq~Zt,t%F:carbonyl reductase (NADPH) activitysq~Zt,t&F:protein disulfide isomerase activitysq~Zt,tF:antigen bindingsq~Zbt,tF:IMP dehydrogenase activitysq~ZTt,tF:GTPase activitysq~Zt,t C:nucleussq~Zi t,t C:cytoplasmsq~Z t,t&C:proteasome complex (sensu Eukaryota)sq~Zt,tC:soluble fractionsq~Zt,t C:cytosolsq~Zt,tC:intracellularsq~Zt,t0C:cytosolic small ribosomal subunit (sensu Eu...sq~Zkt,tC:mitochondrionsq~Zt,t%C:protein phosphatase type 2A complexsq~Zt,tC:extracellular regionsq~Z>t,t C:membranesq~Zt,t0C:cytosolic large ribosomal subunit (sensu Eu...sq~Zt,tC:plasma membranesq~Zt,tC:extracellular spacesq~Z t,tC:chromosome, telomeric regionsq~Zt,tC:endoplasmic reticulum lumensq~Zt,t#C:ER-Golgi intermediate compartmentsq~Zt,tC:trans-Golgi networksq~Zt,t+C:proteasome core complex (sensu Eukaryota)sq~Zt,t0C:proteasome regulatory particle (sensu Eukar...sq~ZSt,t.C:ribonucleoside-diphosphate reductase complexsq~Zt,t C:polysomesq~Zt,t0C:eukaryotic translation elongation factor 1 ...sq~Zt,t"C:muscle thin filament tropomyosinsq~Zt,tC:endoplasmic reticulumsq~Zt,tC:mitochondrial matrixsq~Z~t,t#C:mitochondrial intermembrane spacesq~Z t,tC:nuclear poresq~Zt,t"C:DNA replication factor C complexsq~ZAt,tC:telomerase holoenzyme complexsq~Zt,t(C:NuA4 histone acetyltransferase complexsq~Z.t,tC:chromatin assembly complexsq~Z1t,t C:spliceosomesq~Zbt,t C:nucleolussq~Zot,tC:mitochondrial inner membranesq~Z=t,tC:microtubule cytoskeletonsq~Z= t,tC:actin cytoskeletonsq~Zyt,t0C:mitochondrial proton-transporting ATP synth...sq~Z't,tC:cell surfacesq~Zt,tC:cytoskeletonppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxpsq~uq~ sq~t,t IPR002877tRrmJFtsJ_mtfrasesq~t,t IPR015507trRNA-MeTfrase_Jppppppppxsq~uq~ sq~t,tFtsJtPF01728pppppppppxtQ9UET6t RRMJ1_HUMANsq~uq~ sq~t,t&rRNA (uridine-2'-O-)-methyltransferasepppppppppxt Homo sapienstPSD11sq~P?$C],s,%t/26S proteasome non-ATPase regulatory subunit 11sq~uq~ sq~UstENSG00000108671pppppppppxsq~uq~ sq~mstPSMD11pppppppppxsq~suq~ sq~Z st0P:transforming growth factor beta receptor si...sq~ZDst0P:negative regulation of transcription, DNA-d...sq~Zst,P:regulation of transcription, DNA-dependentsq~ZstP:translational elongationsq~Zw-stP:BMP signaling pathwaysq~ZdstP:synaptic transmissionsq~Z&st!P:embryonic pattern specificationsq~ZstP:nervous system developmentsq~Zst/P:transcription from RNA polymerase II promotersq~Zst0P:regulation of transcription from RNA polyme...sq~Z&stP:organ morphogenesissq~ZstP:nucleotide-excision repairsq~ZstP:base-excision repairsq~Z [stP:cell proliferationsq~Zst0P:nucleobase, nucleoside, nucleotide and nucl...sq~Zst0P:generation of precursor metabolites and energysq~Z!st%P:caspase activation via cytochrome csq~Z \st+P:positive regulation of cell proliferationsq~ZGstP:ER overload responsesq~ZFst&P:protein amino acid dephosphorylationsq~ZstP:phototransductionsq~Zst P:cell agingsq~Zst$P:central nervous system developmentsq~Z|stP:female gamete generationsq~Zkst&P:multicellular organismal developmentsq~ZRst)P:activation of NF-kappaB-inducing kinasesq~ZJst!P:intracellular signaling cascadesq~Zst0P:transmembrane receptor protein tyrosine pho...sq~ZstP:SMAD protein complex assemblysq~ZstP:cell cycle arrestsq~Zst P:apoptosissq~ZnstP:ATP-dependent proteolysissq~Zlst P:proteolysissq~ZstP:protein localizationsq~Z&st&P:anterior/posterior pattern formationsq~Z@ast&P:negative regulation of transcriptionsq~Z>stP:protein tetramerizationsq~ZmstP:cell fate commitmentsq~ZFst0P:negative regulation of myeloid cell differe...sq~Zxst0P:positive regulation of transcription from R...sq~Z6st0P:regulation of mitochondrial membrane permea...sq~Zst!P:paraxial mesoderm morphogenesissq~ZƤst#P:T cell receptor signaling pathwaysq~Zƶst*P:positive regulation of T cell activationsq~ZǙst*P:negative regulation of helicase activitysq~Z st0P:positive regulation of T cell cytokine prod...sq~ZstP:mesonephros developmentsq~ZstP:mesoderm formationsq~ZǚstP:regulation of bindingsq~Zsst0P:positive regulation of I-kappaB kinase/NF-k...sq~ZstP:protein polyubiquitinationsq~Zust0P:negative regulation of Wnt receptor signali...sq~Zvdst$P:negative regulation of cell growthsq~Zst P:glycolysissq~Zst)P:cellular response to glucose starvationsq~Zst0P:DNA damage response, signal transduction by...sq~ZstF:protein bindingsq~ZtstF:transcription factor activitysq~Z@st"F:transcription activator activitysq~ZstF:transcription factor bindingsq~ZAstF:ATPase activitysq~Zst%F:receptor signaling protein activitysq~Zst F:GTP bindingsq~Zst(F:translation elongation factor activitysq~ZstF:histone bindingsq~Z NstF:zinc ion bindingsq~Z}stF:protein N-terminus bindingsq~ZMstF:enzyme bindingsq~Zst%F:protein heterodimerization activitysq~Z@st-F:specific transcriptional repressor activitysq~Z3st#F:protein homodimerization activitysq~Z=stF:dihydropyrimidinase activitysq~Zst0F:transmembrane receptor protein tyrosine pho...sq~ZTstF:GTPase activitysq~Z st0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZstF:copper ion bindingsq~ZstF:nuclease activitysq~Zust'F:protein tyrosine phosphatase activitysq~Zst#F:ubiquitin-protein ligase activitysq~Zst(F:protein phosphatase inhibitor activitysq~ZstF:signal transducer activitysq~ZstF:receptor activitysq~Zst F:ATP bindingsq~Zst F:RNA bindingsq~ZjstF:double-stranded DNA bindingsq~ZstF:growth factor activitysq~ZstF:DNA strand annealing activitysq~Zst!F:transcription cofactor activitysq~Z]st F:DNA bindingsq~Zst$F:transcription coactivator activitysq~Zst C:nucleussq~Zst&C:proteasome complex (sensu Eukaryota)sq~Zst0C:proteasome regulatory particle (sensu Eukar...sq~Zist C:cytoplasmsq~ZkstC:mitochondrionsq~ZstC:intracellularsq~Z#stC:transcription factor complexsq~Z>stC:integral to membranesq~Zst C:cytosolsq~Z@st C:PML bodysq~Zst0C:eukaryotic translation elongation factor 1 ...sq~Zst C:polysomesq~ZstC:endoplasmic reticulumsq~Z= stC:actin cytoskeletonsq~Z>st C:membranesq~Z?stC:nuclear matrixsq~Zbst C:nucleolussq~Zst C:nucleoplasmsq~Z@stC:nuclear specksq~ZBst#C:transcriptional repressor complexsq~ZstC:insoluble fractionsq~ZstC:soluble fractionsq~ZstC:extracellular spacesq~ZstC:Bcl3/NF-kappaB2 complexsq~ZstC:integral to plasma membranepppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~stF:protein bindingt5515sq~st&C:proteasome complex (sensu Eukaryota)t502ppppppppxsq~uq~ sq~st IPR013143tPAMsq~st IPR000717tPCIsq~st IPR011991tWing_hlx_DNA_bdpppppppxsq~uq~ sq~stPCItPF01399pppppppppxtO00231t PSD11_HUMANsq~uq~ sq~st$26S proteasome regulatory subunit S9sq~st'26S proteasome regulatory subunit p44.5ppppppppxt Homo sapienstGDITsq~P?aa{%t Rho GDP-dissociation inhibitor 3sq~uq~ sq~U{tENSG00000206156pppppppppxsq~uq~ sq~m{tARHGDIGpppppppppxsq~'uq~ (sq~Zb{t!P:Rho protein signal transductionsq~ZuT{t0P:actin cytoskeleton organization and biogenesissq~Z{tP:cell adhesionsq~ZJ{t.P:regulation of progression through cell cyclesq~ZuP{tP:lamellipodium biogenesissq~ZuY{tP:actin filament polymerizationsq~Zv {tP:T cell differentiationsq~Zv{tP:macrophage differentiationsq~Zz*{t/P:positive regulation of pseudopodium formationsq~Zze{t0P:negative regulation of protein complex asse...sq~Z{){t$P:ruffle organization and biogenesissq~Z{t0P:positive regulation of Rho protein signal t...sq~Zj{t0P:positive regulation of NF-kappaB import 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signal transductiont7266sq~{t)F:Rho GDP-dissociation inhibitor activityt5094sq~{t$C:cytoplasmic membrane-bound vesiclet16023ppppppxsq~uq~ sq~{t IPR000406tRho_GDIpppppppppxsq~uq~ sq~{tRho_GDItPF02115pppppppppxtQ99819t GDIT_HUMANsq~uq~ sq~{t Rho GDI 3sq~{t Rho-GDI gammappppppppxt Homo sapienstNFKB2sq~P?OЁ%t&Nuclear factor NF-kappa-B p100 subunitsq~uq~ sq~UtENSG00000077150pppppppppxsq~uq~ sq~mtNFKB2sq~mtLYT10ppppppppxsq~4uq~ @sq~Z t P:translationsq~Z tP:signal transductionsq~ZJtP:response to unfolded proteinsq~Z9tP:protein foldingsq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~ZtP:anti-apoptosissq~ZtP:induction of apoptosissq~Z*tP:inflammatory responsesq~Z tP:RNA splicingsq~Zt/P:transcription from RNA polymerase II promotersq~Zt,P:regulation of transcription, DNA-dependentsq~Z=tP:protein complex assemblysq~Zt0P:regulation of transcription from RNA polyme...sq~ZJt.P:regulation of progression through cell cyclesq~Zut&P:positive regulation of transcriptionsq~ZFt&P:protein amino 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processsq~Zvdt$P:negative regulation of cell growthsq~Z|tP:female gamete generationsq~ZvtP:monocyte differentiationsq~Zv tP:platelet formationsq~Zv tP:erythrocyte differentiationsq~ZvtP:keratinocyte differentiationsq~ZutP:regulation of cell adhesionsq~Zut.P:regulation of Wnt receptor signaling pathwaysq~Zu`tP:actin filament-based movementsq~ZMt%P:second-messenger-mediated signalingsq~Zkt&P:multicellular organismal developmentsq~ZKt0P:cytokine and chemokine mediated signaling p...sq~ZFtP:peptide cross-linkingsq~Zrt(P:fructose 6-phosphate metabolic processsq~ZwtP:maturation of SSU-rRNAsq~ZtP:chromatin silencingsq~ZtP:mitochondrial transportsq~Zt!P:intracellular protein transportsq~ZtP:nucleocytoplasmic transportsq~ZUt'P:cytoplasmic sequestering of NF-kappaBsq~Z(tP:defense responsesq~Z+tP:immune responsesq~Z^t0P:mitochondrial membrane organization and bio...sq~ZitP:microtubule-based processsq~ZjtP:microtubule-based movementsq~ZltP:microtubule nucleationsq~Zt-P:mitotic spindle organization and biogenesissq~Zt0P:G-protein coupled receptor protein signalin...sq~Z=t%P:integrin-mediated signaling pathwaysq~ZtP:ceramide metabolic processsq~ZtP:fatty acid beta-oxidationsq~ZtP:transcriptionsq~ZtP:rRNA processingsq~Zt0P:transcription initiation from RNA polymeras...sq~ZtP:mRNA polyadenylationsq~ZctP:cell-cell signalingsq~Z tP:translational initiationsq~ZtP:arginyl-tRNA aminoacylationsq~Z@tP:protein modification processsq~ZGt%P:protein amino acid ADP-ribosylationsq~Zmt)P:membrane protein ectodomain proteolysissq~ZtP:protein targetingsq~Zt+P:NLS-bearing substrate import into nucleussq~ZtP:fatty acid metabolic processsq~ZTtP:I-kappaB phosphorylationsq~ZtP:nervous system developmentsq~Z<t,P:protein import into nucleus, translocationsq~Z%t$P:anatomical structure morphogenesissq~ZEt0P:positive regulation of transcription, DNA-d...sq~ZDt0P:negative regulation of transcription, DNA-d...sq~Z%tP:response to virussq~Z$tP:pathogenesissq~Zt0P:positive regulation of protein biosynthetic...sq~Zt$P:regulation of cell differentiationsq~ZtP:nucleosome assemblysq~ZtP:regulation of transcriptionsq~Zgt0P:negative regulation of interleukin-8 biosyn...sq~Zt0P:negative regulation of viral genome replica...sq~Z#t#P:glycoprotein biosynthetic processsq~Z:tP:protein transportsq~Zt)P:blood vessel endothelial cell migrationsq~Z@tP:chromatin modificationsq~Z't#P:regulation of synaptic plasticitysq~ZRt'P:G1/S transition of mitotic cell cyclesq~Z'tP:response to UV-Bsq~Zzt0P:negative regulation of transcription from R...sq~Zt0P:maintenance of protein localization in nucleussq~ZHt&P:positive regulation of cell motilitysq~ZǝtP:regulation of DNA bindingsq~Z't$P:response to extracellular stimulussq~Zt P:cytokinesissq~ZtP:leukocyte migrationsq~ZƤt#P:T cell receptor signaling pathwaysq~Zzt,P:regulation of steroid biosynthetic processsq~Z'tP:response to UV-Csq~ZtP:mRNA stabilizationsq~Zt0P:ribosomal small subunit assembly and mainte...sq~Z!t0P:DNA damage response, signal transduction re...sq~Z!t0P:induction of apoptosis by extracellular sig...sq~Zt+P:natural killer cell mediated cytotoxicitysq~Zit-P:regulation of NF-kappaB import into nucleussq~Z-t0P:tRNA transcription from RNA polymerase III ...sq~Z'tP:5S class rRNA transcriptionsq~Zt0P:DNA damage response, signal transduction by...sq~Zt0P:negative regulation of tyrosine phosphoryla...sq~ZtP:inactivation of MAPK activitysq~ZNt0P:long-term strengthening of neuromuscular ju...sq~Z*tP:protein refoldingsq~Zt0P:cytoplasmic sequestering of transcription f...sq~Z{,t#P:actin cytoskeleton reorganizationsq~ZrtP:primary sex determinationsq~ZtP:axon guidancesq~ZtP:regulation of apoptosissq~Z:t"P:negative regulation of apoptosissq~Z tP:regulation of cell shapesq~Z=t.P:negative regulation of programmed cell deathsq~Z=5tP:gas transportsq~Zt)P:negative regulation of caspase activitysq~Z!tP:male gonad developmentsq~Zt$P:negative regulation of DNA bindingsq~Zt0P:proteasomal ubiquitin-dependent protein 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endopeptidase activitysq~Zt*F:3-hydroxyacyl-CoA dehydrogenase activitysq~ZtF:antigen bindingsq~Zt%F:protein heterodimerization activitysq~ZstF:NF-kappaB bindingsq~ZtF:ATPase activity, coupledsq~Zvt*F:nitric-oxide synthase regulator activitysq~Zw@t"F:transcription regulator activitysq~ZxtF:TPR domain bindingsq~Zrt/F:protein serine/threonine phosphatase activitysq~ZGtF:actin filament bindingsq~Z>t*F:low-density lipoprotein receptor bindingsq~ZtF:protein anchorsq~ZtF:caspase inhibitor activitysq~Z?{t0F:general RNA polymerase II transcription fac...sq~ZMtF:protein kinase bindingsq~Zyt0F:RNA splicing factor activity, transesterifi...sq~Z{+t0F:thyrotropin-releasing hormone receptor bindingsq~Z{t"F:ubiquitin protein ligase bindingsq~Z|t*F:N-terminal myristoylation domain bindingsq~Z0tF:MHC class I protein bindingsq~Z=tF:phosphate bindingsq~Z@t"F:transcription repressor activitysq~Z@t"F:transcription activator activitysq~ZutF:chaperone regulator activitysq~Z tF:ribonucleoprotein bindingsq~ZvHt%F:structural constituent of epidermissq~Zt F:GTP bindingsq~ZOt$F:myosin light chain kinase activitysq~Z"tF:helicase activitysq~ZOtF:endopeptidase activitysq~ZtF:creatine kinase activitysq~Zt0F:carbamoyl-phosphate synthase (glutamine-hyd...sq~Zt'F:acetyl-CoA C-acyltransferase activitysq~Znt&F:NAD+ ADP-ribosyltransferase activitysq~ZTtF:GTPase activitysq~Zut'F:protein tyrosine phosphatase activitysq~Zt!F:methionine-tRNA ligase activitysq~Zt#F:ubiquitin-protein ligase activitysq~ZtF:calmodulin bindingsq~ZtF:Ras GTPase activator activitysq~ZtF:GTPase activator activitysq~ZtF:receptor bindingsq~ZtF:GTPase inhibitor activitysq~ZtF:scavenger receptor activitysq~Zt"F:glucocorticoid receptor activitysq~Zt,F:ligand-dependent nuclear receptor activitysq~Z t F:6-phosphofructokinase activitysq~ZtF:microtubule motor activitysq~ZtF:poly(A) bindingsq~Z JtF:poly(U) bindingsq~Z NtF:zinc ion bindingsq~Z tF:IkappaB kinase activitysq~Z!.t F:translation activator activitysq~Z^tF:DNA helicase activitysq~Z!t0F:protein phosphatase type 2A regulator activitysq~ZtF:microfilament motor activitysq~Z#_tF:electron carrier activitysq~ZVtF:protein C-terminus bindingsq~Zt0F:translation factor activity, nucleic acid b...sq~ZtF:double-stranded RNA bindingsq~Zt$F:transcription corepressor activitysq~ZjtF:double-stranded DNA bindingsq~Zyt0F:RNA polymerase II transcription factor acti...sq~Zt)F:acetyl-CoA C-acetyltransferase activitysq~Zt!F:transcription cofactor activitysq~Zvt0F:RNA polymerase II transcription factor acti...sq~Zit C:cytoplasmsq~Zt C:nucleussq~Zt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Zt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Zbt C:nucleolussq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zt C:cytosolsq~ZtC:soluble fractionsq~ZtC:cytoskeletonsq~ZktC:mitochondrionsq~Zt0C:proteasome regulatory particle (sensu Eukar...sq~ZtC:intracellularsq~Z'tC:cell surfacesq~ZtC:mitochondrial matrixsq~Z1t C:spliceosomesq~ZvtC:histone deacetylase complexsq~ZwBt0C:heterogeneous nuclear ribonucleoprotein com...sq~ZtC:plasma membranesq~Z}tC:cleavage furrowsq~Zt(C:NuA4 histone acetyltransferase complexsq~ZtC:intermediate filamentsq~ZutC:clathrin coatsq~ZtC:cytoplasmic microtubulesq~ZtC:integral to plasma membranesq~Zut,C:integral to endoplasmic reticulum membranesq~Z2t C:cell cortexsq~Z9tC:6-phosphofructokinase complexsq~Zt C:microtubulesq~ZtC:actin filamentsq~Zt C:nucleoplasmsq~ZWt!C:perinuclear region of cytoplasmsq~Zt%C:transcription factor TFIIIC complexsq~ZtC:Golgi membranesq~Z=tC:microtubule cytoskeletonsq~ZtC:ubiquitin ligase complexsq~Zt%C:protein phosphatase type 2A complexsq~Z>t C:membranesq~Zt C:nucleosomesq~ZtC:cornified envelopesq~ZtC:stress fibersq~ZtC:rufflesq~Z>tC:integral to membranesq~ZtC:cytoplasmic dynein complexsq~Z@tC:nuclear specksq~ZtC:Bcl3/NF-kappaB2 complexsq~ZtC:extracellular spacesq~Zt#C:histone methyltransferase complexsq~ZtC:membrane fractionsq~Z$tC:polysomal ribosomesq~Z2t C:snRNP U5sq~ZDt.C:NLS-dependent protein nuclear import complexsq~ZtC:nuclear envelopesq~ZtC:nuclear inner membranesq~Z tC:nuclear poresq~ZtC:Bcl3-Bcl10 complexsq~Zpt0C:mitochondrial inner membrane presequence tr...sq~ZltC:mitochondrial envelopesq~Zt+C:proteasome core complex (sensu Eukaryota)sq~ZtC:cytoplasmic partsq~Zt&C:cytosolic ribosome (sensu Eukaryota)sq~ZtC:contractile ringsq~ZtC:microtubule organizing centersq~ZtC:protein complexsq~Zt#C:ER-Golgi intermediate compartmentsq~ZwAtC:ribonucleoprotein complexsq~ZwDt)C:small nuclear ribonucleoprotein complexsq~ZtC:endoplasmic reticulum lumensq~Z#tC:transcription factor complexppppppppppppxsq~uq~ sq~t,P:regulation of transcription, DNA-dependentt6355sq~t$F:transcription coactivator activityt3713sq~tF:transcription factor activityt3700sq~tC:Bcl3/NF-kappaB2 complext33257sq~t C:cytoplasmt5737sq~t C:nucleust5634ppppxsq~uq~ sq~t IPR002110tANKsq~t IPR000488tDeathsq~t IPR011029t DEATH_likesq~t IPR013783t Ig-like_foldsq~t IPR002909t IPT_TIG_rcptsq~t IPR015682tNF-kappaB_related2sq~t IPR000451t NF_Rel_dorsq~t IPR011539tRHDppxsq~uq~ sq~tAnktPF00023sq~tDeathtPF00531sq~tRHDtPF00554sq~tTIGtPF01833ppppppxtQ00653t NFKB2_HUMANsq~uq~ sq~tDNA-binding factor KBF2sq~tH2TF1sq~t&Lymphocyte translocation chromosome 10sq~tOncogene Lyt-10sq~tLyt10sq~t%Nuclear factor NF-kappa-B p52 subunitppppxt Homo sapienstCRCMsq~P?ta&g%t Colorectal mutant cancer proteinsq~uq~ sq~U>ENSG00000171444pppppppppxsq~uq~ sq~m&gtMCCpppppppppxsq~uq~ sq~Z&gtP:signal transductionsq~Zt&gtP:DNA replicationsq~Z.&gt(P:regulation of translational initiationsq~ZJ&gt.P:regulation of progression through cell cyclesq~ZD&gt$P:protein amino acid phosphorylationsq~Z ]&gt+P:negative regulation of cell proliferationsq~Z&&gtP:response to stresssq~Z&gt!P:intracellular protein transportsq~Z [&gtP:cell proliferationsq~Z&gtP:translational elongationsq~Z=&gtP:protein complex assemblysq~ZR&gt'P:G1/S transition of mitotic cell cyclesq~Z &gt P:translationsq~Z&gtP:cell cycle arrestsq~Z&gtP:lipid metabolic processsq~Z&gtP:anti-apoptosissq~Z&gtP:induction of apoptosissq~ZW&gt P:carbohydrate metabolic processsq~ZF&gt&P:protein amino acid dephosphorylationsq~ZE&gt0P:positive regulation of transcription, DNA-d...sq~Z&gt(P:ER to Golgi vesicle-mediated transportsq~Zo&gt/P:ubiquitin-dependent protein catabolic processsq~Z&gtP:cell motilitysq~Zs&gt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z&gtP:base-excision repairsq~Z&gt P:DNA repairsq~Z9&gtP:protein foldingsq~Z&gtP:tricarboxylic acid cyclesq~Z&gtP:regulation of transcriptionsq~Z&gt/P:transcription from RNA polymerase II promotersq~Z &gtP:translational initiationsq~Z&gt$P:DNA fragmentation during apoptosissq~Z&gtP:transcriptionsq~Z&gtP:mismatch repairsq~Z&gtP:chloride transportsq~Z!&gt0P:induction of apoptosis by intracellular sig...sq~Z*&gtP:inflammatory responsesq~ZJ&gt+P:N-terminal protein amino acid acetylationsq~Z&gtP:fatty acid beta-oxidationsq~Zl&gt P:proteolysissq~Z&gtP:visual perceptionsq~Z&gt P:glycolysissq~Z&gt P:endocytosissq~Z&gt0P:generation of precursor metabolites and energysq~Z&gtP:skeletal developmentsq~Zk&gt&P:multicellular organismal developmentsq~Z &gtP:RNA splicingsq~Z`&gt+P:small GTPase mediated signal transductionsq~Z]&gtP:muscle developmentsq~Za&gt!P:Ras protein signal transductionsq~Z@&gtP:protein ubiquitinationsq~Z&gt P:cell cyclesq~Z%&gt$P:anatomical structure morphogenesissq~Z$&gtP:response to heatsq~Z%&gtP:response to hormone stimulussq~Z&&gtP:response to glucose stimulussq~Z:&gtP:protein transportsq~Z&&gtP:organ morphogenesissq~Z'1&gtP:response to organic substancesq~Z&gtP:postreplication repairsq~Z&gtP:double-strand break repairsq~Z6&gtP:oligodendrocyte developmentsq~Z&gtP:DNA modificationsq~Z&gtP:DNA recombinationsq~Z&gtP:DNA packagingsq~Z&gtP:nucleotide-excision repairsq~Z$N&gtP:DNA mediated transformationsq~Z$&gt0P:pyrimidine ribonucleotide biosynthetic processsq~Z&gtP:protein localizationsq~Z&gt P:behaviorsq~Z&gtP:regulation of glycolysissq~Z ^&gt$P:insulin receptor signaling pathwaysq~Z&gt(P:purine nucleotide biosynthetic processsq~Z!`&gtP:epidermis developmentsq~Z-&gt$P:'de novo' IMP biosynthetic processsq~Z!&gtP:male gonad developmentsq~Z&gtP:purine ribonucleoside salvagesq~Zu&gtP:DNA-dependent DNA replicationsq~Z!&gtP:apoptotic programsq~Z!&gt%P:caspase activation via cytochrome csq~Z#&gt"P:purine base biosynthetic processsq~Z~&gtP:DNA replication initiationsq~Z#&gtP:nucleotide metabolic processsq~Z&gtP:regulation of DNA replicationsq~Z#&gt.P:ribonucleoside diphosphate catabolic processsq~Z&gtP:glucosamine catabolic processsq~Z&gt P:cell agingsq~Z&gt P:mitosissq~Z&gtP:sister chromatid cohesionsq~Z&gt-P:mitotic spindle organization and biogenesissq~Zn&gt%P:chaperonin-mediated tubulin foldingsq~Zh&gtP:cytoskeletal anchoringsq~ZY&gt0P:chromosome organization and biogenesis (sen...sq~ZJ&gtP:response to unfolded proteinsq~ZC&gtP:response to oxidative stresssq~Z>&gt!P:response to DNA damage stimulussq~Z+&gtP:immune responsesq~Z&gt!P:mitotic chromosome condensationsq~Z&gtP:centrosome cyclesq~Z&gt$P:central nervous system developmentsq~Z&gtP:single fertilizationsq~Zs&gtP:spermatogenesissq~Zd&gtP:synaptic transmissionsq~Zc&gtP:cell-cell signalingsq~Z-&gt0P:acetylcholine receptor signaling, muscarini...sq~Z&gt0P:epidermal growth factor receptor signaling ...sq~Z&gtP:cell communicationsq~Z&gtP:male meiosis Isq~Z&gt P:meiosissq~Z&gt"P:regulation of muscle contractionsq~Z&gt P:chemotaxissq~ZV&gt"P:protein amino acid glycosylationsq~ZO&gt P:protein amino acid methylationsq~ZK&gt)P:internal protein amino acid acetylationsq~ZJ&gt'P:one-carbon compound metabolic processsq~Z@&gtP:protein modification processsq~Z&gtP:mRNA processingsq~Z&gt+P:transcription from mitochondrial promotersq~Z&gt0P:regulation of transcription from RNA polyme...sq~Z&gt0P:regulation of transcription from RNA polyme...sq~Z&gt,P:regulation of transcription, DNA-dependentsq~Zn&gtP:ATP-dependent proteolysissq~Z&gtP:protein targeting to membranesq~Z&gt-P:tRNA aminoacylation for protein translationsq~Z&gtP:caspase activationsq~Z&gtP:nucleocytoplasmic transportsq~Z&gt(P:intra-Golgi vesicle-mediated transportsq~Z&gt0P:retrograde vesicle-mediated transport, Golg...sq~Z&gtP:cellular iron ion homeostasissq~Z&gtP:anion transportsq~Z^&gt"P:glutathione biosynthetic processsq~Z'&gt"P:cholesterol biosynthetic processsq~Z&gtP:ceramide metabolic processsq~Z&gtP:nucleosome disassemblysq~Z&gt)P:retrograde transport, endosome to Golgisq~Z&gtP:glutamate metabolic processsq~Z&gt-P:positive regulation of cell differentiationsq~ZD&gt0P:negative regulation of transcription, DNA-d...sq~Zvd&gt$P:negative regulation of cell growthsq~Zg&gtP:positive regulation of growthsq~Zu&gtP:regulation of cell adhesionsq~Zu&gtP:cell differentiationsq~Zu&gt.P:regulation of Wnt receptor signaling pathwaysq~Zu&gtP:protein repairsq~Z&gt0P:positive regulation of dopamine metabolic p...sq~Z&gt P:hypoxanthine metabolic processsq~Z&gt(P:protein amino acid autophosphorylationsq~Z&gt+P:mitochondrion transport along microtubulesq~Z&gt%P:phosphoinositide-mediated signalingsq~Zi&gtP:synaptic vesicle transportsq~Zv&gt'P:negative regulation of cell migrationsq~Zv&gt)P:ER-associated protein catabolic processsq~Z&gtP:response to drugsq~Z&gt0P:negative regulation of tyrosine phosphoryla...sq~Z&gt0P:Golgi to plasma membrane CFTR protein trans...sq~Z9&gt"P:positive regulation of apoptosissq~Z:&gt"P:negative regulation of apoptosissq~Z&gt&P:response to peptide hormone stimulussq~Z&gtP:histone exchangesq~Zy&gt0P:negative regulation of microtubule polymeri...sq~Zx&gt-P:retrograde protein transport, ER to cytosolsq~Zx&gtP:unfolded protein responsesq~Z2&gt$P:maintenance of DNA repeat elementssq~Z &gtP:leukocyte activationsq~Z&gtP:cellular respirationsq~Z&gt$P:regulation of cell differentiationsq~Zw&gtP:maturation of SSU-rRNAsq~Z&gt0P:ribosomal small subunit assembly and mainte...sq~ZY&gtP:protein homotetramerizationsq~Z>&gt P:cell growthsq~ZKg&gtP:D-ribose catabolic processsq~Z&gtP:inactivation of MAPK activitysq~Z&gt0P:mRNA catabolic process, nonsense-mediated d...sq~Z&gtP:MAPKKK cascadesq~Z&gt0P:two-component signal transduction system (p...sq~ZGg&gt0P:protein amino acid N-linked glycosylation v...sq~Z&gtP:cellular response to stimulussq~Zz&gt0P:negative regulation of transcription from R...sq~ZV&gt'P:G2/M transition of mitotic cell cyclesq~ZO&gt0P:regulation of cyclin-dependent protein kina...sq~ZK&gtP:cell cycle checkpointsq~Z@a&gt&P:negative regulation of transcriptionsq~Z&gtP:ribosome assemblysq~Z>&gtP:mRNA metabolic processsq~ZU&gtP:regulation of phosphorylationsq~Zh&gt0P:cis assembly of U2-type pre-catalytic splic...sq~Zƅ&gtP:protein stabilizationsq~Z&gt!P:regulation of blood vessel sizesq~Z &gtP:blastocyst developmentsq~Z&gt$P:prostaglandin biosynthetic processsq~ZI&gt!P:actin filament bundle formationsq~ZM&gt%P:second-messenger-mediated signalingsq~Z&gtP:cell morphogenesissq~Zǔ&gt.P:activation of NF-kappaB transcription factorsq~Z&gt(P:nuclear mRNA splicing, via spliceosomesq~Z?@&gtP:vesicle-mediated transportsq~Zǝ&gtP:regulation of DNA bindingsq~Z&gtP:telomere maintenancesq~ZK&gt"P:leukotriene biosynthetic processsq~Zk&gtF:protein bindingsq~Z &gt F:ATP bindingsq~Z &gt F:RNA bindingsq~ZT&gtF:GTPase activitysq~Z2&gtF:identical protein bindingsq~Z&gt$F:structural constituent of ribosomesq~ZNJ&gtF:unfolded protein bindingsq~Z&gt0F:translation factor activity, nucleic acid b...sq~Z&gtF:signal transducer activitysq~Z&gt(F:translation initiation factor activitysq~Z&gt$F:transcription coactivator activitysq~Z&gt%F:protein heterodimerization activitysq~Z]&gt F:DNA bindingsq~ZB&gt*F:protein serine/threonine kinase activitysq~Z&gtF:calmodulin bindingsq~Z&gt F:GTP bindingsq~ZN&gtF:structural molecule activitysq~Z3&gt#F:protein homodimerization activitysq~Z&gtF:actin bindingsq~Z &gt F:6-phosphofructokinase activitysq~ZV&gtF:protein C-terminus bindingsq~Z&gt(F:translation elongation factor activitysq~Z&gtF:transcription factor bindingsq~Zt&gtF:transcription factor activitysq~Z&gtF:chloride channel activitysq~ZM&gtF:enzyme bindingsq~Z &gtF:3'-5' exonuclease activitysq~ZB&gt$F:nucleoside-triphosphatase activitysq~ZA&gtF:ATPase activitysq~ZQ&gtF:microtubule bindingsq~ZI&gtF:casein kinase I activitysq~Z#_&gtF:electron carrier activitysq~Z&gtF:receptor activitysq~Zv{&gtF:estrogen receptor bindingsq~Z&gtF:enoyl-CoA hydratase activitysq~ZW&gt F:NAD bindingsq~Z!X&gtF:Ran GTPase bindingsq~Z~&gtF:MutLalpha complex bindingsq~Z s&gt"F:structural constituent of musclesq~Z?P&gt F:AMP bindingsq~Z}&gt,F:dinucleotide insertion or deletion bindingsq~Zu&gtF:ADP reductase activitysq~Zs&gtF:NF-kappaB bindingsq~Z&gt!F:ribosomal small subunit bindingsq~Z!&gt0F:protein phosphatase type 2A regulator activitysq~Z&gtF:phosphoinositide bindingsq~Zʧ&gtF:Hsp90 protein bindingsq~Z@k&gtF:oxidoreductase activitysq~Z@&gt"F:transcription activator activitysq~Z@&gt-F:specific transcriptional repressor activitysq~Z&gt0F:glutamate-cysteine ligase catalytic subunit...sq~ZJ&gt"F:ADP-sugar diphosphatase activitysq~ZK&gtF:nucleoside kinase activitysq~Z}&gt!F:guanine/thymine mispair bindingsq~Z" &gt+F:D-alanyl-D-alanine endopeptidase activitysq~Zy&gt0F:RNA splicing factor activity, transesterifi...sq~Z N&gtF:zinc ion bindingsq~ZG&gtF:actin filament bindingsq~Zg&gtF:beta-tubulin bindingsq~Z&gtF:N-acetyltransferase activitysq~Zo&gtF:enzyme activator activitysq~Zw&gtF:protein binding, bridgingsq~Zw&gt+F:arsenate reductase (thioredoxin) activitysq~Z&gtF:dynein bindingsq~Z&gtF:metal ion bindingsq~Zw,&gt0F:thiol-disulfide exchange intermediate activitysq~ZY<&gt&F:voltage-gated anion channel activitysq~Z!&gt)F:phosphorylase kinase regulator activitysq~Zc&gt0F:electron transporter, transferring electron...sq~Ze&gtF:protein self-associationsq~ZB&gtF:microtubule plus-end bindingsq~Z )&gtF:peptidase activitysq~ZZ&gt!F:ATP-dependent helicase activitysq~Z(&gt$F:insulin receptor substrate bindingsq~Z&gtF:O-methyltransferase activitysq~Z&gt0F:positive transcription elongation factor ac...sq~Z,&gt#F:prostaglandin-E synthase activitysq~Zx&gtF:Tat protein bindingsq~ZNE&gtF:heme bindingsq~Zu&gt.F:receptor signaling complex scaffold activitysq~Zx&gtF:steroid bindingsq~Z&gtF:transketolase activitysq~Z&gtF:transaldolase activitysq~Z&gt/F:ribonucleoside-diphosphate reductase activitysq~Z&gt0F:pyruvate dehydrogenase (acetyl-transferring...sq~Z{&gt*F:purine-nucleoside phosphorylase activitysq~Zu&gt'F:protein tyrosine phosphatase activitysq~Zo&gt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~Zi&gt"F:protein-tyrosine kinase activitysq~Ze&gt#F:MAP kinase kinase kinase activitysq~ZU&gt*F:cyclin-dependent protein kinase activitysq~Z@&gtF:protein kinase activitysq~Z"&gt0F:phosphoribosylformylglycinamidine synthase ...sq~Z&gt0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~Z&gt*F:ornithine-oxo-acid transaminase activitysq~Z&gt.F:caspase-activated deoxyribonuclease activitysq~Z&gtF:phosphodiesterase I activitysq~Z&gt!F:methionine-tRNA ligase activitysq~Z&gtF:valine-tRNA ligase activitysq~Z&gtF:calcium ion bindingsq~Z&gtF:FK506 bindingsq~Z_&gtF:transporter activitysq~Z"&gt*F:epidermal growth factor receptor bindingsq~Z&gtF:cytokine activitysq~Z&gtF:receptor bindingsq~Z&gtF:Ras GTPase activator activitysq~Z&gtF:fatty acid bindingsq~Z&gtF:SH3/SH2 adaptor activitysq~Z&gt%F:GDP-dissociation inhibitor activitysq~Z&gtF:transferrin receptor activitysq~Z&gt0F:cyclin-dependent protein kinase inhibitor a...sq~Z&gt"F:phospholipase inhibitor activitysq~Z&gtF:uridine kinase activitysq~Z&gt#F:uracil DNA N-glycosylase activitysq~Z&gt#F:ubiquitin-protein ligase activitysq~Z&gtF:ribonuclease H activitysq~Z&gt F:endodeoxyribonuclease activitysq~Z&gt0F:methylenetetrahydrofolate dehydrogenase act...sq~Z&gt%F:ATP-dependent RNA helicase activitysq~Z&gt,F:adenine phosphoribosyltransferase activitysq~Z&gt!F:acetyl-CoA carboxylase activitysq~Z&gt)F:acetyl-CoA C-acetyltransferase activitysq~Z&gt0F:UDP-glucose:glycoprotein glucosyltransferas...sq~ZB&gt0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~Z&gtF:antigen bindingsq~Z&gtF:microtubule motor activitysq~Z&gt&F:protein disulfide isomerase activitysq~Z&gt.F:peptidyl-prolyl cis-trans isomerase activitysq~Z&gt%F:translation release factor activitysq~Z&gtF:telomerase activitysq~Z&gt$F:transcription corepressor activitysq~Z&gt-F:transcription elongation regulator activitysq~Z&gt0F:purine-specific mismatch base pair DNA N-gl...sq~Z&gtF:magnesium ion bindingsq~Z&gtF:aldehyde reductase activitysq~Z&gt!F:adenosylhomocysteinase activitysq~Z&gtF:adenylate kinase activitysq~Z}&gt0F:methenyltetrahydrofolate cyclohydrolase act...sq~ZF&gt0F:hypoxanthine phosphoribosyltransferase acti...sq~Z &gt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~Z&gt,F:glucosamine-6-phosphate deaminase activitysq~Z&gt*F:formate-tetrahydrofolate ligase activitysq~Z&gtF:epoxide hydrolase activitysq~Z&gt#F:tripeptidyl-peptidase II activitysq~Z&gt"F:acylaminoacyl-peptidase activitysq~Z}&gt"F:ubiquitin thiolesterase activitysq~Z &gt F:citrate (Si)-synthase activitysq~Z&gt%F:carbonyl reductase (NADPH) activitysq~ZQ&gtF:aminopeptidase activitysq~Z&gtF:carboxylesterase activitysq~ZO&gtF:endopeptidase activitysq~Z1&gtF:tRNA bindingsq~Z&gt C:nucleussq~Zi&gt C:cytoplasmsq~Z &gt C:cytosolsq~Zk &gtC:mitochondrionsq~Z &gtC:soluble fractionsq~Z&gtC:endoplasmic reticulumsq~Z&gt&C:proteasome complex (sensu Eukaryota)sq~Z&gt0C:eukaryotic translation initiation factor 3 ...sq~Z&gtC:membrane fractionsq~Z&gtC:intracellularsq~Z>&gt C:membranesq~Z&gt%C:protein phosphatase type 2A complexsq~Zb&gt C:nucleolussq~Z&gt0C:proteasome regulatory particle (sensu Eukar...sq~Z&gtC:mitochondrial matrixsq~Z&gt C:endosomesq~Z&gtC:integral to plasma membranesq~Z=&gtC:microtubule cytoskeletonsq~Z&gt0C:eukaryotic translation elongation factor 1 ...sq~Z&gtC:plasma membranesq~Z~-&gtC:MutSalpha complexsq~Z&gt"C:muscle thin filament tropomyosinsq~Z&gtC:cytoskeletonsq~Z&gt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z&gt C:microsomesq~Z b&gt!C:F-actin capping protein complexsq~Z&gt C:centrosomesq~ZW&gt!C:perinuclear region of cytoplasmsq~Z&gt C:microvillussq~Z?&gt0C:eukaryotic translation initiation factor 4F...sq~Z&gt0C:cytosolic small ribosomal subunit (sensu Eu...sq~Z&gtC:extracellular spacesq~Z&gtC:extracellular regionsq~Z9&gtC:6-phosphofructokinase complexsq~Z>&gt$C:cytoplasmic membrane-bound vesiclesq~Z &gtC:chromosome, telomeric regionsq~Z&gt C:ribosomesq~ZS&gt.C:ribonucleoside-diphosphate reductase complexsq~Z&gt+C:proteasome core complex (sensu Eukaryota)sq~Z&gtC:actin filamentsq~ZR&gtC:pore complexsq~Z&gtC:postsynaptic membranesq~Z'&gtC:keratin filamentsq~Z&gt C:polysomesq~Z&gt0C:eukaryotic translation initiation factor 2B...sq~Z&gtC:brush bordersq~ZW&gt)C:transcription elongation factor complexsq~Z&gtC:rufflesq~Z&gt C:microtubulesq~Z&gtC:stress fibersq~Z&gtC:spindle polesq~Z&gtC:condensin complexsq~Z2&gt C:cell cortexsq~Z :&gt$C:oligosaccharyl transferase complexsq~Z&gtC:condensed nuclear chromosomesq~Z&gt C:chromatinsq~Z V&gtC:cohesin complexsq~Z&gtC:trans-Golgi networksq~Z&gtC:Golgi apparatussq~Z>&gtC:integral to membranesq~Zy&gt#C:cortical microtubule cytoskeletonsq~ZM&gtC:extrinsic to membranesq~Z2&gt C:snRNP U5sq~Z1&gt C:spliceosomesq~Zx&gtC:cortical cytoskeletonsq~Z+&gtC:holo TFIIH complexsq~Z#&gtC:transcription factor complexsq~Z?&gtC:prefoldin complexsq~Zw &gt C:midbodysq~Z?&gtC:nuclear matrixsq~Z@K&gtC:myosin complexsq~Z&gt"C:DNA replication factor C complexsq~Z&gt&C:alpha DNA polymerase:primase complexsq~Z@&gt,C:DNA-directed RNA polymerase II, holoenzymesq~Zu&gtC:COPI vesicle coatsq~Zu&gtC:clathrin coatsq~Z= &gtC:actin cytoskeletonsq~Z}&gtC:cleavage furrowsq~Z&gtC:nuclear envelopesq~Z&gt C:endoplasmic reticulum membranesq~Z&gtC:endoplasmic reticulum lumensq~Z&gtC:protein complexsq~Z&gt C:peroxisomesq~Z&gtC:late endosomesq~Z&gt C:lysosomesq~Z&gt'C:mitochondrial small ribosomal subunitsq~Z;&gt C:MCM complexsq~Z~&gt#C:mitochondrial intermembrane spacesq~Zo&gtC:mitochondrial inner membranesq~Z&gtC:paraspecklessq~Zm&gtC:mitochondrial outer membranesq~Z'&gtC:cell surfacesq~ZA&gtC:telomerase holoenzyme complexsq~Z5&gtC:Elongator core complexsq~Z6&gt C:snRNP U2sq~Z~.&gtC:MutSbeta complexsq~Z&gtC:basement membraneppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~&gtP:signal transductiont7165sq~&gtF:protein bindingt5515sq~&gtF:receptor activityt4872pppppppxpptP23508t CRCM_HUMANsq~uq~ sq~> Protein MCCpppppppppxt Homo sapienstMAXsq~P?Zld*E"+%t Protein maxsq~uq~ sq~UE"tENSG00000125952pppppppppxsq~uq~ sq~mE"tMAXpppppppppxsq~huq~ sq~ZE"t/P:transcription from RNA polymerase II promotersq~ZE"tP:signal transductionsq~ZE"t0P:regulation of transcription from RNA polyme...sq~ZJE"t.P:regulation of progression through cell cyclesq~Z [E"tP:cell proliferationsq~ZE"t P:apoptosissq~Z ]E"t+P:negative regulation of cell proliferationsq~ZE"t,P:regulation of transcription, DNA-dependentsq~ZDE"t$P:protein amino acid phosphorylationsq~ZE"tP:response to hypoxiasq~ZkE"t&P:multicellular organismal developmentsq~ZxE"t0P:positive regulation of transcription from R...sq~ZlE"t P:proteolysissq~ZE"t0P:cell surface receptor linked signal transdu...sq~ZE"tP:cell cycle arrestsq~Z E"t0P:transforming growth factor beta receptor si...sq~Z>E"t!P:response to DNA damage stimulussq~ZE"tP:SMAD protein complex assemblysq~ZE"tP:mitotic cell cycle checkpointsq~ZtE"tP:DNA replicationsq~ZE"t P:chemotaxissq~ZE"tP:cell motilitysq~Z&E"tP:response to stresssq~ZIE"t P:protein amino acid acetylationsq~ZFE"t&P:protein amino acid dephosphorylationsq~ZE"tP:base-excision repairsq~ZE"tP:chromatin remodelingsq~ZE"tP:postreplication repairsq~ZE"tP:mismatch repairsq~ZKE"tP:protein kinase cascadesq~ZsE"tP:spermatogenesissq~ZYE"tP:mitotic metaphasesq~ZE"tP:regulation of transcriptionsq~Z2E"t$P:maintenance of DNA repeat elementssq~ZE"tP:cellular iron ion homeostasissq~ZE"t0P:cytoplasmic sequestering of transcription f...sq~ZE"t+P:mitochondrion transport along microtubulesq~ZE"t0P:positive regulation of global transcription...sq~ZzE"t0P:negative regulation of transcription from R...sq~ZUE"tP:regulation of phosphorylationsq~Z]E"tP:mitotic telophasesq~Z@E"tP:histone acetylationsq~Z \E"t+P:positive regulation of cell proliferationsq~Z!E"tP:apoptotic programsq~ZZE"tP:mitotic anaphasesq~Z`E"tP:homeostatic processsq~ZE"tF:protein bindingsq~Zt E"tF:transcription factor activitysq~ZE"t$F:transcription coactivator activitysq~ZE"t$F:transcription corepressor activitysq~Z]E"t F:DNA bindingsq~Z3E"t#F:protein homodimerization activitysq~Z@E"t"F:transcription activator activitysq~ZE"t#F:histone acetyltransferase bindingsq~Z *E"t"F:cysteine-type peptidase activitysq~ZVE"tF:protein C-terminus bindingsq~ZvE"t0F:RNA polymerase II transcription factor acti...sq~ZE"t!F:transcription cofactor activitysq~ZyE"t0F:RNA polymerase II transcription factor acti...sq~ZE"t F:RNA bindingsq~Zw@E"t"F:transcription regulator activitysq~ZJE"tF:histone deacetylase bindingsq~Z E"tF:MP kinase activitysq~Z@E"tF:protein kinase activitysq~Z;E"t&F:DNA-directed RNA polymerase activitysq~Z?{E"t0F:general RNA polymerase II transcription fac...sq~Z}E"t!F:guanine/thymine mispair bindingsq~ZJE"tF:protein kinase CK2 activitysq~ZBZE"t*F:transcription initiation factor activitysq~ZdE"tF:MAP kinase kinase activitysq~ZgE"tF:beta-tubulin bindingsq~Z-E"tF:sequence-specific DNA bindingsq~ZQE"tF:microtubule bindingsq~Z}E"tF:protein N-terminus bindingsq~ZE"t%F:protein heterodimerization activitysq~ZE"t%F:protein phosphatase type 1 activitysq~Z E"t C:nucleussq~Z#E"tC:transcription factor complexsq~ZE"t C:chromatinsq~ZE"tC:mitochondrial matrixsq~ZE"tC:condensed nuclear chromosomesq~Z}E"tC:PCAF complexsq~Z;E"t C:MCM complexsq~ZWE"t!C:perinuclear region of cytoplasmsq~ZE"t&C:proteasome complex (sensu Eukaryota)sq~ZE"t(C:NuA4 histone acetyltransferase complexsq~ZE"tC:intracellularsq~Z~.E"tC:MutSbeta complexsq~ZE"t C:polysomesq~ZE"t C:spindlesq~ZE"t C:centrosomesq~ZE"t C:endoplasmic reticulum membranesq~ZmE"tC:mitochondrial outer membranesq~ZkE"tC:mitochondrionsq~ZE"tC:plasma membranesq~ZiE"t C:cytoplasmsq~ZbE"t C:nucleolussq~Z%E"t$C:transcription factor TFIID complexsq~Z!E"t.C:DNA-directed RNA polymerase II, core complexsq~Z>E"tC:integral to membranesq~ZuE"tC:transport vesiclesq~Z|E"tC:mitochondrial membranesq~Z~-E"tC:MutSalpha complexsq~ZE"tC:cytoskeletonppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~E"t/P:transcription from RNA polymerase II promotert6366sq~E"t$F:transcription coactivator activityt3713sq~E"tF:transcription factor activityt3700pppppppxsq~uq~ sq~E"t IPR001092t HLH_basicsq~E"t IPR011598t HLH_DNA_bdppppppppxsq~uq~ sq~E"tHLHtPF00010pppppppppxtP61244t MAX_HUMANsq~uq~ sq~E"tMyc-associated factor Xpppppppppxt Homo sapienstCK049sq~PLH%t Uncharacterized protein C11orf49sq~uq~ sq~ULHtENSG00000149179pppppppppxsq~uq~ sq~mLHtC11orf49pppppppppxsq~uq~ sq~ZLHtP:induction of apoptosissq~Z LHtP:translational initiationsq~Z LHt P:translationsq~ZLHt F:RNA bindingsq~ZLHt$F:structural constituent of ribosomesq~Z2LHtF:identical protein bindingsq~ZLHtF:protein bindingsq~ZLHt C:nucleussq~ZLHt C:polysomesq~ZLHt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZLHt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZLHt C:cytosolsq~ZLHt C:endoplasmic reticulum membranesq~ZLHt&C:proteasome complex (sensu Eukaryota)ppppppxppptQ9H6J7t CK049_HUMANpt Homo sapienstGFI1Bsq~P?mռ XDX%tZinc finger protein Gfi-1bsq~uq~ sq~UDtENSG00000165702pppppppppxsq~uq~ sq~mDtGFI1Bpppppppppxsq~uq~ @sq~ZDtP:signal transductionsq~ZDtP:cell adhesionsq~ZDt/P:transcription from RNA polymerase II promotersq~ZDt"P:regulation of cell proliferationsq~ZDtP:regulation of apoptosissq~ZsDtP:spermatogenesissq~Z3DtP:Notch signaling pathwaysq~ZvDt'P:positive regulation of cell migrationsq~ZDt#P:positive regulation of DNA repairsq~ZiDtP:receptor clusteringsq~ZBDt0P:DNA damage response, signal transduction by...sq~ZDt0P:regulation of transcription from RNA polyme...sq~ZDt.P:negative regulation of centriole replicationsq~ZDtP:focal adhesion formationsq~ZDtP:metabolic processsq~Z!Dt0P:DNA damage response, signal transduction re...sq~Z!Dt.P:release of cytoplasmic sequestered NF-kappaBsq~ZdDtP:synaptic transmissionsq~ZjDt%P:neuromuscular synaptic transmissionsq~ZDtP:nervous system developmentsq~Z ]Dt+P:negative regulation of cell proliferationsq~ZDt P:lactationsq~Z [DtP:cell proliferationsq~ZDt(P:negative regulation of DNA replicationsq~ZDtP:visual perceptionsq~Z`Dt+P:small GTPase mediated signal transductionsq~ZDtP:anti-apoptosissq~ZDtP:striated muscle contractionsq~Z+DtP:immune responsesq~Z8DtP:cellular defense responsesq~Z>Dt!P:response to DNA damage stimulussq~ZlDtP:microtubule nucleationsq~ZDt P:cell cyclesq~ZDtP:chromosome segregationsq~ZDtP:cell-matrix adhesionsq~ZDt0P:cell surface receptor linked signal transdu...sq~Z%DtP:protein kinase C activationsq~ZDt0P:retrograde vesicle-mediated transport, Golg...sq~Z-Dt0P:acetylcholine receptor signaling, muscarini...sq~Z&DtP:organ morphogenesissq~Z&Dt(P:auditory receptor cell fate commitmentsq~Z&Dt#P:regulation of signal transductionsq~ZiDt!P:neuronal ion channel clusteringsq~ZjDt-P:clustering of voltage-gated sodium channelssq~Z^Dt0P:negative regulation of myoblast differentia...sq~ZDt0P:negative regulation of fatty acid biosynthe...sq~ZDt'P:positive regulation of anti-apoptosissq~ZDt0P:negative regulation of progression through ...sq~ZDt0P:negative regulation of gene expression, epi...sq~Z#Dt'P:regulation of protein kinase activitysq~ZEDt0P:positive regulation of transcription, DNA-d...sq~ZZDt)P:negative regulation of JAK-STAT cascadesq~ZDt(P:protein amino acid autophosphorylationsq~ZDtP:microtubule polymerizationsq~ZDt0P:positive regulation of epithelial cell prol...sq~ZxDt%P:synapse organization and biogenesissq~ZDtP:thymic T cell selectionsq~ZkDtP:response to estrogen stimulussq~Z&Dt&P:DNA methylation during gametogenesissq~Z=DtP:monoamine transportsq~Z?@DtP:vesicle-mediated transportsq~Z?EDtP:endosome transportsq~Z@aDt&P:negative regulation of transcriptionsq~ZKDt&P:triacylglycerol biosynthetic processsq~ZvdDt$P:negative regulation of cell growthsq~Zv~DtP:regulation of cell migrationsq~Zw9Dt%P:androgen receptor signaling pathwaysq~ZeDtP:cell divisionsq~ZyDtP:neurite developmentsq~ZzDt/P:positive regulation of protein ubiquitinationsq~Z{TDt'P:G2/M transition DNA damage checkpointsq~ZDtP:odontogenesissq~Z%Dt.P:DNA methylation during embryonic developmentsq~ZGDt&P:negative regulation of cell motilitysq~ZDDt$P:protein amino acid phosphorylationsq~Z"DtP:vasculogenesissq~ZDt0P:double-strand break repair via homologous r...sq~ZDtP:regulation of transcriptionsq~ZzDt0P:negative regulation of transcription from R...sq~ZDtP:cell fate determinationsq~ZPDt P:G1 phase of mitotic cell cyclesq~ZDt0P:nucleobase, nucleoside, nucleotide and nucl...sq~ZDtP:postreplication repairsq~ZDt,P:regulation of transcription, DNA-dependentsq~ZDt0P:regulation of transcription from RNA polyme...sq~ZDtP:RNA processingsq~Z=DtP:protein complex assemblysq~Z9DtP:protein foldingsq~Z Dt P:translationsq~ZDtF:protein bindingsq~ZNDtF:structural molecule activitysq~ZDtF:calcium ion bindingsq~Z=DtF:tubulin bindingsq~ZQDt-F:extracellular matrix structural constituentsq~ZDt$F:transcription coactivator activitysq~ZDt F:RNA bindingsq~Z NDtF:zinc ion bindingsq~ZDtF:growth factor activitysq~ZDtF:protein kinase C bindingsq~Z:DtF:integrin bindingsq~ZDtF:rDNA bindingsq~ZDt!F:small GTPase regulator activitysq~ZDtF:androgen receptor bindingsq~ZDt0F:transforming growth factor beta receptor ac...sq~Z\DtF:nucleic acid bindingsq~ZNJDtF:unfolded protein bindingsq~ZvDt0F:RNA polymerase II transcription factor acti...sq~ZDtF:receptor bindingsq~ZDtF:Notch bindingsq~ZDt F:interleukin-1 receptor bindingsq~Z,Dt(F:tumor necrosis factor receptor bindingsq~Z5DtF:actinin bindingsq~ZjDt0F:transmembrane receptor protein tyrosine kin...sq~Z]Dt F:DNA bindingsq~ZbDtF:chromatin bindingsq~ZpDtF:satellite DNA bindingsq~ZtDtF:transcription factor activitysq~Z Dt'F:peroxisome targeting sequence bindingsq~ZBDt*F:protein serine/threonine kinase activitysq~ZDt!F:transcription cofactor activitysq~ZDtF:metal ion bindingsq~ZDt(F:translation initiation factor activitysq~ZDtF:laminin bindingsq~ZDtF:actin bindingsq~Z2Dt$F:histone acetyltransferase activitysq~ZvDt"F:thyroid hormone receptor bindingsq~ZDt,F:guanyl-nucleotide exchange factor activitysq~ZuDtF:PDZ domain bindingsq~Z@Dt"F:transcription activator activitysq~ZADtF:ATPase activitysq~Z DtF:acyltransferase activitysq~ZCDtF:vinculin bindingsq~ZPDt(F:structural constituent of cytoskeletonsq~ZMDtF:enzyme bindingsq~ZVDtF:protein C-terminus bindingsq~ZMDtF:kinase bindingsq~ZiDt C:cytoplasmsq~ZDt C:nucleussq~ZDt$C:proteinaceous extracellular matrixsq~ZDtC:basal laminasq~ZDtC:membrane fractionsq~ZDtC:endoplasmic reticulumsq~ZDtC:soluble fractionsq~ZDt C:nucleoplasmsq~ZWDt!C:perinuclear region of cytoplasmsq~Z%DtC:focal adhesionsq~ZDtC:integral to plasma membranesq~ZDtC:extracellular regionsq~Z RDtC:gamma-tubulin ring complexsq~ZDt&C:proteasome complex (sensu Eukaryota)sq~ZDt C:chromosome, pericentric regionsq~ZDtC:mitochondrial matrixsq~ZDtC:early endosomesq~ZDtC:Golgi apparatussq~ZDt C:cytosolsq~ZwBDt0C:heterogeneous nuclear ribonucleoprotein com...sq~Z= DtC:actin cytoskeletonsq~ZDt"C:nuclear ubiquitin ligase complexsq~ZDt0C:eukaryotic translation initiation factor 3 ...sq~ZDtC:plasma membranesq~ZbDt C:nucleolussq~ZzDtC:BRCA1-BARD1 complexsq~Z>DtC:integral to membranesq~Z|DtC:nuclear membranesq~ZDtC:presynaptic membranesq~ZDtC:basement membranesq~ZDtC:laminin-1 complexsq~ZDtC:laminin-8 complexsq~ZDtC:laminin-10 complexsq~ZDtC:extracellular spacesq~Z SDtC:gamma-tubulin small complexsq~ZDt C:microtubule associated complexsq~ZDtC:nuclear inner membranesq~ZDtC:laminin-2 complexsq~Z%Dt$C:transcription factor TFIID complexsq~ZyDtC:pseudopodiumppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~DtP:cell proliferationt8283sq~Dt0P:G1-specific transcription in mitotic cell c...t114sq~Dt0P:negative regulation of transcription from R...t122sq~DtF:protein bindingt5515sq~Dt0F:specific RNA polymerase II transcription fa...t3704pppppxsq~uq~ sq~Dt IPR007087tZnf_C2H2sq~Dt IPR007086t Znf_C2H2_subppppppppxsq~uq~ sq~Dtzf-C2H2tPF00096pppppppppxtQ5VTD9t GFI1B_HUMANsq~uq~ sq~Dt$Growth factor independent protein 1Bsq~Dt1Potential regulator of CDKN1A translocated in CMLppppppppxt Homo sapienstCASP4sq~P?݀ez0Q]1%tCaspase-4 precursorsq~uq~ sq~UQ]tENSG00000196954pppppppppxsq~uq~ sq~mQ]tCASP4sq~mQ]tICH2ppppppppxsq~uq~ sq~ZQ]tP:signal transductionsq~Z!`Q]tP:epidermis developmentsq~ZQ]t P:mitosissq~ZQ]t!P:mitotic chromosome condensationsq~Z*Q]tP:inflammatory responsesq~ZQ]t P:meiosissq~ZcQ]tP:cell-cell signalingsq~ZQ]tP:nervous system developmentsq~Z$Q]t0P:folic acid and derivative biosynthetic processsq~ZQ]t-P:mitotic spindle organization and biogenesissq~ZQ]tP:anti-apoptosissq~ZQ]tP:induction of apoptosissq~ZQ]t P:apoptosissq~ZkQ]t&P:multicellular organismal developmentsq~ZsQ]tP:spermatogenesissq~Z|Q]tP:female gamete generationsq~ZQ]t!P:cellular copper ion homeostasissq~ZYQ]t0P:chromosome organization and biogenesis (sen...sq~ZQ]t!P:mitochondrial citrate transportsq~Z [Q]tP:cell proliferationsq~Z \Q]t+P:positive regulation of cell proliferationsq~Z ]Q]t+P:negative regulation of cell proliferationsq~ZdQ]tP:synaptic transmissionsq~ZQ]t!P:intracellular protein transportsq~Z`Q]t+P:small GTPase mediated signal transductionsq~ZQ]tP:chromosome segregationsq~ZQ]tP:sister chromatid cohesionsq~ZQ]t#P:mitotic sister chromatid cohesionsq~ZQ]t0P:traversing start control point of mitotic c...sq~ZQ]t(P:intra-Golgi vesicle-mediated transportsq~Z4Q]tP:Notch receptor processingsq~ZQQ]t#P:I-kappaB kinase/NF-kappaB cascadesq~ZYQ]tP:activation of JNK activitysq~ZQ]tP:anion transportsq~Z!Q]tP:apoptotic programsq~ZnQ]t$P:interleukin-2 biosynthetic processsq~ZoQ]t'P:interferon-gamma biosynthetic processsq~ZxQ]t0P:positive regulation of activated T cell pro...sq~ZQ]t%P:interleukin-13 biosynthetic processsq~Z Q]t0P:granulocyte macrophage colony-stimulating f...sq~ZUQ]tP:regulation of phosphorylationsq~ZQ]tP:defense response to bacteriumsq~ZQ]t*P:DNA damage response, signal transductionsq~ZQ]t-P:amyloid precursor protein catabolic processsq~Z:Q]t"P:negative regulation of apoptosissq~ZMQ]t(P:positive regulation of enzyme activitysq~ZsQ]t0P:positive regulation of I-kappaB kinase/NF-k...sq~ZQ]tP:neuromuscular processsq~ZFQ]tP:actin filament severingsq~ZlQ]t!P:T-helper 2 type immune responsesq~ZhQ]t!P:T-helper 1 type immune responsesq~Z1Q]t P:chemokine biosynthetic processsq~Z!Q]t%P:caspase activation via cytochrome csq~Z$NQ]tP:DNA mediated transformationsq~Z$bQ]tP:response to radiationsq~Z=Q]tP:glutamate transportsq~Z=Q]tP:adenine transportsq~Z>Q]tP:detection of bacteriumsq~Z@eQ]tP:protein processingsq~Z;Q]tP:protein oligomerizationsq~ZFQ]tP:peptide cross-linkingsq~ZuYQ]tP:actin filament polymerizationsq~ZuQ]tP:regulation of cell adhesionsq~ZvQ]tP:keratinocyte differentiationsq~Zv8Q]t(P:nuclear fragmentation during apoptosissq~ZvQ]tP:sleepsq~ZHQ]t#P:barbed-end actin filament cappingsq~Z"Q]tP:icosanoid metabolic processsq~ZQ]t0P:platelet activating factor biosynthetic pro...sq~ZQ]tP:angiogenesissq~ZQ]t$P:interleukin-8 biosynthetic processsq~ZQ]t(P:nuclear mRNA splicing, via spliceosomesq~ZVQ]t'P:G2/M transition of mitotic cell cyclesq~ZKQ]tP:cell cycle checkpointsq~ZNQ]tP:UMP biosynthetic processsq~ZQ]tP:regulation of DNA replicationsq~ZQ]t P:DNA repairsq~ZQ]tP:base-excision repairsq~ZnQ]tP:ATP-dependent proteolysissq~ZmQ]t)P:membrane protein ectodomain proteolysissq~ZlQ]t P:proteolysissq~Z=Q]tP:protein complex assemblysq~Z Q]tP:translational initiationsq~ZQ]t,P:regulation of transcription, DNA-dependentsq~ZQ]tP:mismatch repairsq~ZQ]tF:protein bindingsq~ZQ]t%F:protein heterodimerization activitysq~ZQ]t F:ATP bindingsq~ZwQ]tF:caspase activitysq~ZQ]tF:signal transducer activitysq~Z2Q]tF:identical protein bindingsq~ZQ]tF:calcium ion bindingsq~Z!Q]tF:caspase activator activitysq~ZQ]t.F:serine-type endopeptidase inhibitor activitysq~ZY<Q]t&F:voltage-gated anion channel activitysq~ZQ]tF:microtubule motor activitysq~ZQ]t*F:formate-tetrahydrofolate ligase activitysq~ZAQ]tF:ATPase activitysq~ZQ]tF:dynein bindingsq~Z}Q]t0F:methenyltetrahydrofolate cyclohydrolase act...sq~ZQ]tF:nucleotide bindingsq~ZQ]t0F:methylenetetrahydrofolate dehydrogenase (NA...sq~ZQ]t(F:translation initiation factor activitysq~ZNJQ]tF:unfolded protein bindingsq~ZBQ]t$F:nucleoside-triphosphatase activitysq~ZQ]t,F:orotate phosphoribosyltransferase activitysq~Z"Q]tF:helicase activitysq~Z\Q]tF:nucleic acid bindingsq~ZQ]t0F:purine-specific mismatch base pair DNA N-gl...sq~ZeQ]t&F:cysteine-type endopeptidase activitysq~ZOQ]tF:endopeptidase activitysq~ZwQ]tF:protein binding, bridgingsq~ZRQ]tF:peptidoglycan bindingsq~ZbQ]tF:chromatin bindingsq~Z}Q]t,F:dinucleotide insertion or deletion bindingsq~ZTQ]tF:GTPase activitysq~ZQ]t/F:orotidine-5'-phosphate decarboxylase activitysq~ZQ]t F:interleukin-1 receptor bindingsq~ZQ]tF:GTPase activator activitysq~ZPQ]t(F:structural constituent of cytoskeletonsq~Z;!Q]t,F:citrate transmembrane transporter activitysq~ZQ]t0F:L-glutamate transmembrane transporter activitysq~ZUQ]t*F:cyclin-dependent protein kinase activitysq~ZQ]t0F:translation factor activity, nucleic acid b...sq~ZQ]tF:phospholipase A2 activitysq~ZQ]tF:cytokine activitysq~ZiQ]t C:cytoplasmsq~ZQ]t C:cytosolsq~ZQ]t C:nucleussq~ZQ]tC:extracellular regionsq~ZmQ]tC:mitochondrial outer membranesq~ZQ]tC:integral to plasma membranesq~ZQ]tC:spindle polesq~ZQ]tC:condensin complexsq~ZQ]t C:kinetochoresq~ZoQ]tC:mitochondrial inner membranesq~ZQ]t&C:proteasome complex (sensu Eukaryota)sq~ZQ]tC:membrane fractionsq~ZQ]tC:nuclear chromosomesq~ZQ]tC:protein complexsq~ZQ]tC:endoplasmic reticulumsq~ZRQ]tC:pore complexsq~ZQ]tC:cornified envelopesq~ZQ]tC:Golgi apparatussq~Z= Q]tC:actin cytoskeletonsq~ZQ]t C:ribosomesq~Z>Q]tC:integral to membranesq~Z'Q]tC:cell surfacesq~ZuQ]tC:COPI vesicle coatsq~ZkQ]tC:mitochondrionsq~ZQ]tC:extracellular spacesq~ZQ]tC:basement membranesq~ZQ]t$C:integral to nuclear inner membranesq~Z~-Q]tC:MutSalpha complexsq~Z VQ]tC:cohesin complexsq~ZQ]tC:condensed nuclear chromosomesq~Z XQ]tC:cohesin core heterodimersq~Z6Q]t C:snRNP U2sq~Z?Q]tC:nuclear matrixsq~ZQ]tC:translocon complexxsq~uq~ sq~Q]tP:induction of apoptosist6917sq~Q]t P:proteolysist6508sq~Q]tF:protein bindingt5515pppppppxsq~uq~ sq~Q]t IPR001315tCARDsq~Q]t IPR011029t DEATH_likesq~Q]t IPR001309tICE_p20sq~Q]t IPR011600t Pept_C14_catsq~Q]t IPR002138t Pept_C14_p10sq~Q]t IPR002398t Pept_C14_p45ppppxsq~uq~ sq~Q]tCARDtPF00619sq~Q]t Peptidase_C14tPF00656ppppppppxtP49662t CASP4_HUMANsq~uq~ sq~Q]tCASP-4sq~Q]tICH-2 proteasesq~Q]t TX proteasesq~Q]t ICE(rel)-IIsq~Q]tCaspase-4 subunit 1sq~Q]tCaspase-4 subunit 2ppppxt Homo sapienstPAK2sq~P?Q 0GDH%t%Serine/threonine-protein kinase PAK 2sq~uq~ sq~UDtENSG00000180370pppppppppxsq~uq~ sq~mDtPAK2pppppppppxsq~uq~ @sq~ZDDt$P:protein amino acid phosphorylationsq~ZJDt.P:regulation of progression through cell cyclesq~ZDtP:signal transductionsq~ZuTDt0P:actin cytoskeleton organization and biogenesissq~Z.Dt(P:regulation of translational initiationsq~Z Dt P:translationsq~ZFDt#P:peptidyl-tyrosine phosphorylationsq~ZKDtP:protein kinase cascadesq~Z [DtP:cell proliferationsq~Z UDt0P:regulation of G-protein coupled receptor pr...sq~ZDtP:cell adhesionsq~ZDtP:signal complex assemblysq~ZcDtP:cell-cell signalingsq~ZdDtP:synaptic transmissionsq~ZDtP:induction of apoptosissq~ZDt P:apoptosissq~Z ^Dt$P:insulin receptor signaling pathwaysq~ZDt/P:transcription from RNA polymerase II promotersq~ZDtP:cell motilitysq~ZDt,P:regulation of transcription, DNA-dependentsq~ZJDt'P:one-carbon compound metabolic processsq~ZDt0P:transmembrane receptor protein tyrosine kin...sq~ZDt0P:epidermal growth factor receptor signaling ...sq~ZDtP:mismatch repairsq~ZDtP:base-excision repairsq~ZDt P:chemotaxissq~Z`Dt+P:small GTPase mediated signal transductionsq~ZaDt!P:Ras protein signal transductionsq~ZbDt!P:Rho protein signal transductionsq~ZDtP:regulation of DNA repairsq~ZDtP:mRNA processingsq~ZDt0P:establishment and/or maintenance of cell po...sq~ZDt0P:regulation of transcription from RNA polyme...sq~ZDtP:fatty acid beta-oxidationsq~ZDt"P:cellular calcium ion homeostasissq~ZDtP:protein export from nucleussq~ZlDt P:proteolysissq~ZODt P:protein amino acid methylationsq~ZDtP:regulation of apoptosissq~ZDt+P:regulation of striated muscle contractionsq~Z@DtP:protein modification processsq~Z&DtP:response to stresssq~Z*DtP:inflammatory responsesq~ZDtP:calcium ion transportsq~ZDtP:regulation of mitosissq~ZVDt P:JNK cascadesq~ZkDt&P:multicellular organismal developmentsq~Zv~DtP:regulation of cell migrationsq~ZxvDt0P:positive regulation of actin filament polym...sq~Zz*Dt/P:positive regulation of pseudopodium formationsq~Z{)Dt$P:ruffle organization and biogenesissq~ZDt0P:positive regulation of Rho protein signal t...sq~ZvDt-P:positive regulation of T cell proliferationsq~Z#Dt0P:positive regulation of tyrosine phosphoryla...sq~ZaDtP:glucose homeostasissq~Z:Dt"P:negative regulation of apoptosissq~ZsDt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZDtP:stress fiber formationsq~ZDt0P:positive regulation of gene-specific transc...sq~ZDtP:focal adhesion formationsq~ZDt0P:negative regulation of receptor mediated en...sq~ZƤDt#P:T cell receptor signaling pathwaysq~ZǔDt.P:activation of NF-kappaB transcription factorsq~Zv8Dt(P:nuclear fragmentation during apoptosissq~ZvDtP:macrophage differentiationsq~Zv DtP:erythrocyte differentiationsq~ZDtP:nervous system developmentsq~ZJDtP:mesoderm developmentsq~ZDtP:feeding behaviorsq~ZDt&P:establishment of blood-nerve barriersq~Z \Dt+P:positive regulation of cell proliferationsq~Z ]Dt+P:negative regulation of cell proliferationsq~Z!DtP:male gonad developmentsq~Z!Dt0P:DNA damage response, signal transduction re...sq~Z%DtP:response to hormone stimulussq~Z=DtP:glucose transportsq~Z(Dt/P:positive regulation of stress fiber formationsq~ZGDt0P:peptidyl-proline hydroxylation to 4-hydroxy...sq~ZuPDtP:lamellipodium biogenesissq~ZuYDtP:actin filament polymerizationsq~ZuDtP:protein repairsq~ZuDtP:cell differentiationsq~ZǝDtP:regulation of DNA bindingsq~Z~DtP:DNA replication initiationsq~ZsDt0P:S-phase-specific transcription in mitotic c...sq~ZzeDt0P:negative regulation of protein complex asse...sq~Z-Dt&P:epithelial to mesenchymal transitionsq~ZDtP:skeletal developmentsq~ZDt P:learningsq~ZDtP:protein polyubiquitinationsq~Z)DtF:protein bindingsq~ZDt F:RNA bindingsq~ZDt F:ATP bindingsq~ZiDt"F:protein-tyrosine kinase activitysq~Z]Dt F:DNA bindingsq~Z2DtF:identical protein bindingsq~ZDt(F:translation initiation factor activitysq~ZDt$F:structural constituent of ribosomesq~ZPDt(F:structural constituent of cytoskeletonsq~ZcDtF:MAP kinase activitysq~ZBDt*F:protein serine/threonine kinase activitysq~Z sDt"F:structural constituent of musclesq~ZDtF:cytoskeletal adaptor activitysq~ZTDtF:GTPase activitysq~ZDtF:actin bindingsq~ZDtF:SH3/SH2 adaptor activitysq~ZDt$F:transcription corepressor activitysq~ZDtF:calcium ion bindingsq~Z@Dt"F:transcription activator activitysq~ZvDt0F:RNA polymerase II transcription factor acti...sq~Z0Dt,F:procollagen-proline 4-dioxygenase activitysq~Z(Dt$F:insulin receptor substrate bindingsq~Z@DtF:protein kinase activitysq~ZDtF:metal ion bindingsq~ZODt$F:myosin light chain kinase activitysq~ZxDtF:GTP-dependent protein bindingsq~ZDt!F:adenosylhomocysteinase activitysq~Z!Dt0F:protein phosphatase type 2A regulator activitysq~ZSDtF:RNA cap bindingsq~Z Dt"F:phosphatidylethanolamine bindingsq~Z DtF:3'-5' exonuclease activitysq~ZDtF:magnesium ion bindingsq~ZCDtF:vinculin bindingsq~ZDtF:phosphodiesterase I activitysq~ZBDt0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~ZDt&F:protein disulfide isomerase activitysq~ZDtF:acid phosphatase activitysq~ZuDt.F:receptor signaling complex scaffold activitysq~ZuDtF:manganese ion bindingsq~ZDtF:adenylate kinase activitysq~ZDtF:SH2 domain bindingsq~ZDtF:enoyl-CoA hydratase activitysq~ZwDtF:caspase activitysq~ZDt F:endodeoxyribonuclease activitysq~ZDt$F:transcription coactivator activitysq~ZKDtF:nucleoside kinase activitysq~ZDtF:ribonuclease H activitysq~Z@kDtF:oxidoreductase activitysq~ZtDtF:transcription factor activitysq~ZDt)F:Rab GDP-dissociation inhibitor activitysq~ZDtF:receptor bindingsq~Z"Dt*F:epidermal growth factor receptor bindingsq~Z&DtF:insulin receptor bindingsq~Z_DtF:transporter activitysq~ZxDtF:steroid bindingsq~Z Dt"F:glutathione transferase activitysq~ZDt F:GTP bindingsq~ZDt0F:Rho guanyl-nucleotide exchange factor activitysq~ZVDtF:protein C-terminus bindingsq~ZlDt0F:receptor signaling protein tyrosine kinase ...sq~ZoDt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~ZDt#F:uracil DNA N-glycosylase activitysq~Z NDtF:zinc ion bindingsq~ZDt0F:translation factor activity, nucleic acid b...sq~ZDtF:cytoskeletal protein bindingsq~ZDt"F:phospholipase inhibitor activitysq~ZDtF:GTPase activator activitysq~ZkDt0F:non-membrane spanning protein tyrosine kina...sq~Zi Dt C:cytoplasmsq~Z Dt C:nucleussq~ZDtC:endoplasmic reticulumsq~ZDt&C:proteasome complex (sensu Eukaryota)sq~ZDtC:soluble fractionsq~Z'DtC:cell surfacesq~Z?Dt0C:eukaryotic translation initiation factor 4F...sq~ZDt C:cytosolsq~ZDt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZDtC:plasma membranesq~ZDtC:stress fibersq~ZuKDtC:lamellipodiumsq~ZDtC:intracellularsq~ZDt C:polysomesq~ZDtC:mRNA cleavage factor complexsq~Z2Dt C:cell cortexsq~ZDt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZDt0C:eukaryotic translation initiation factor 3 ...sq~ZDtC:intermediate filamentsq~ZADt C:lipid raftsq~ZDtC:integral to plasma membranesq~ZWDt!C:perinuclear region of cytoplasmsq~ZDtC:zonula adherenssq~Z@KDtC:myosin complexsq~Z$Dt"C:cell-substrate adherens junctionsq~ZDt C:ribosomesq~ZDtC:paraspecklessq~Z>Dt C:membranesq~ZDtC:cytoskeletonsq~ZDtC:extracellular regionsq~ZDtC:membrane fractionsq~ZuDt C:filopodiumsq~ZDt C:nucleoplasmsq~ZDt&C:alpha DNA polymerase:primase complexsq~Zw Dt C:midbodysq~ZbDt C:nucleolussq~ZkDtC:mitochondrionsq~ZmDtC:mitochondrial outer membranesq~ZzDt&C:ubiquitin conjugating enzyme complexsq~ZDtC:endoplasmic reticulum lumensq~Z}DtC:cleavage furrowsq~ZDt#C:ER-Golgi intermediate compartmentsq~ZDt0C:proteasome regulatory particle (sensu Eukar...sq~Z= DtC:actin cytoskeletonppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Dt0P:negative regulation of protein kinase activityt6469sq~Dt(P:protein amino acid autophosphorylationt46777sq~DtP:signal transductiont7165sq~DtF:identical protein bindingt42802sq~Dt*F:protein serine/threonine kinase activityt4674pppppxsq~uq~ sq~Dt IPR000095tPAK_box_Rho_bdsq~Dt IPR015750tPak_likesq~Dt IPR000719tProt_kinase_coresq~Dt IPR008271tSer_thr_pkin_ASsq~Dt IPR002290tSer_thr_pkinasepppppxsq~uq~ sq~DtPBDtPF00786sq~DtPkinasetPF00069ppppppppxtQ13177t PAK2_HUMANsq~ uq~ sq~Dtp21-activated kinase 2sq~DtPAK-2sq~Dt Gamma-PAKsq~DtPAK65sq~Dt S6/H4 kinasesq~Dtp58sq~DtPAK-2p27sq~Dtp27sq~DtPAK-2p34sq~Dtp34sq~DtC-t-PAK2pppppppppxt Homo sapienstPSMD1sq~P?ËI8D%t.26S proteasome non-ATPase regulatory subunit 1sq~uq~ sq~UDtENSG00000173692pppppppppxsq~uq~ sq~mDtPSMD1pppppppppxsq~:uq~ Psq~ZDtP:signal transductionsq~ZDtP:anti-apoptosissq~ZDtP:nucleotide-excision repairsq~Z+DtP:immune responsesq~ZDDt$P:protein amino acid phosphorylationsq~ZsDt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZlDt P:proteolysissq~ZDt P:apoptosissq~ZDt0P:RNA elongation from RNA polymerase II promotersq~Z&DtP:response to stresssq~ZDt,P:regulation of transcription, DNA-dependentsq~ZnDtP:ATP-dependent proteolysissq~ZJDtP:response to unfolded proteinsq~ZuDt0P:positive regulation of nitric oxide biosynt...sq~ZDtP:proteasome assemblysq~Zw-DtP:BMP signaling pathwaysq~ZƶDt*P:positive regulation of T cell activationsq~Z&Dt!P:embryonic pattern specificationsq~ZVDt P:JNK cascadesq~ZRDt)P:activation of NF-kappaB-inducing kinasesq~ZDt0P:cell surface receptor linked signal transdu...sq~ZƤDt#P:T cell receptor signaling pathwaysq~Z Dt0P:transforming growth factor beta receptor si...sq~Z Dt0P:positive regulation of T cell cytokine prod...sq~ZDtP:protein polyubiquitinationsq~ZDtP:response to drugsq~ZJDt.P:regulation of progression through cell cyclesq~ZDtF:protein bindingsq~ZDt F:ATP bindingsq~ZADtF:ATPase activitysq~ZqDtF:single-stranded DNA bindingsq~ZDt$F:transcription coactivator activitysq~ZDt%F:receptor signaling protein activitysq~ZtDtF:transcription factor activitysq~ZDt!F:transmembrane receptor activitysq~ZxDtF:TPR domain bindingsq~ZvDt*F:nitric-oxide synthase regulator activitysq~ZgDtF:beta-tubulin bindingsq~Z@Dt"F:transcription activator activitysq~ZDtF:transcription factor bindingsq~ZDtF:actin bindingsq~ZDt$F:transcription corepressor activitysq~ZDtF:signal transducer activitysq~ZDt#F:ubiquitin-protein ligase activitysq~Z`Dt$F:NF-kappaB-inducing kinase activitysq~ZBDt*F:protein serine/threonine kinase activitysq~Z{DtF:GABA receptor bindingsq~Z!ZDtF:proteasome activator activitysq~ZDt&C:proteasome complex (sensu Eukaryota)sq~ZDt C:nucleussq~ZiDt C:cytoplasmsq~ZDt0C:proteasome regulatory particle (sensu Eukar...sq~ZDtC:Bcl3/NF-kappaB2 complexsq~Z>Dt C:membranesq~ZDtC:cytoskeletonsq~ZDtC:integral to plasma membranesq~ZDtC:membrane fractionsq~Z>DtC:integral to membraneppppppppppppppppppppppxsq~uq~ sq~DtF:protein bindingt5515sq~Dt0C:proteasome regulatory particle (sensu Eukar...t5838ppppppppxsq~uq~ sq~Dt IPR002015tAPC_proteasomesq~Dt IPR011989tARM-likeppppppppxsq~uq~ sq~DtPC_reptPF01851pppppppppxtQ99460t PSMD1_HUMANsq~uq~ sq~Dt&26S proteasome regulatory subunit RPN2sq~Dt$26S proteasome regulatory subunit S1sq~Dt26S proteasome subunit p112pppppppxt Homo sapienstPSMD3sq~P?ǔ5 y2s%t.26S proteasome non-ATPase regulatory subunit 3sq~uq~ sq~UstENSG00000108344pppppppppxsq~uq~ sq~mstPSMD3pppppppppxsq~%uq~ (sq~Zst,P:regulation of transcription, DNA-dependentsq~Zsst0P:positive regulation of I-kappaB kinase/NF-k...sq~ZstP:protein polyubiquitinationsq~ZDst$P:protein amino acid phosphorylationsq~ZnstP:ATP-dependent proteolysissq~Zost/P:ubiquitin-dependent protein catabolic processsq~ZstP:proline biosynthetic processsq~Z+stP:immune responsesq~ZstP:signal transductionsq~ZRst)P:activation of NF-kappaB-inducing kinasesq~Z=stP:glucose transportsq~ZƤst#P:T cell receptor signaling pathwaysq~ZstP:transcription initiationsq~Zƶst*P:positive regulation of T cell activationsq~Z st0P:positive regulation of T cell cytokine prod...sq~Z stF:protein bindingsq~ZAstF:ATPase activitysq~ZwstF:protein binding, bridgingsq~Zw@st"F:transcription regulator activitysq~Z2stF:identical protein bindingsq~ZtstF:transcription factor activitysq~Z NstF:zinc ion bindingsq~Zst$F:transcription coactivator activitysq~Zst(F:translation initiation factor activitysq~Z`st$F:NF-kappaB-inducing kinase activitysq~Zwst0F:prenylated protein tyrosine phosphatase act...sq~Zst F:ATP bindingsq~Z;stF:hormone activitysq~Z st!F:growth hormone receptor bindingsq~ZstF:signal transducer activitysq~Zst#F:ubiquitin-protein ligase activitysq~Zst&C:proteasome complex (sensu Eukaryota)sq~Zst0C:proteasome regulatory particle (sensu Eukar...sq~Zst C:nucleussq~Zist C:cytoplasmsq~ZstC:Bcl3/NF-kappaB2 complexsq~Z#stC:transcription factor complexpppxsq~uq~ sq~stF:protein bindingt5515sq~st&C:proteasome complex (sensu Eukaryota)t502ppppppppxsq~uq~ sq~st IPR013586t26S_Psome_reg_Csq~st IPR013143tPAMsq~st IPR000717tPCIpppppppxsq~uq~ sq~stPCItPF01399sq~stRpn3_CtPF08375ppppppppxtO43242t PSMD3_HUMANsq~uq~ sq~st$26S proteasome regulatory subunit S3sq~stProteasome subunit p58ppppppppxt Homo sapienstPSMD4sq~P?rb 0/1%t.26S proteasome non-ATPase regulatory subunit 4sq~uq~ sq~U/tENSG00000159352pppppppppxsq~uq~ sq~m/tPSMD4sq~m/tMCB1ppppppppxsq~puq~ sq~Zo/t/P:ubiquitin-dependent protein catabolic processsq~Z>/t!P:response to DNA damage stimulussq~Z/t0P:regulation of transcription from RNA polyme...sq~Z \/t+P:positive regulation of cell proliferationsq~Zt/tP:DNA replicationsq~Z/tP:nucleotide-excision repairsq~Z/tP:protein polyubiquitinationsq~Z/t0P:RNA elongation from RNA polymerase II promotersq~ZR/t)P:activation of NF-kappaB-inducing kinasesq~Z/tP:cell cycle arrestsq~Z/t P:cell cyclesq~Z/t P:transportsq~Zs/t0P:positive regulation of I-kappaB kinase/NF-k...sq~Zn/tP:ATP-dependent proteolysissq~Zl/t P:proteolysissq~ZD/t$P:protein amino acid phosphorylationsq~Z/t/P:transcription from RNA polymerase II promotersq~Z9/tP:protein foldingsq~Z/tP:axon guidancesq~ZS/tP:heart developmentsq~Zv/t)P:ER-associated protein catabolic processsq~Zx/t-P:positive regulation of B cell proliferationsq~Zz/t/P:positive regulation of protein ubiquitinationsq~Z@/tP:protein ubiquitinationsq~Z|/t0P:regulation of glucocorticoid metabolic processsq~Z/tP:proteasome assemblysq~Z@a/t&P:negative regulation of transcriptionsq~Z~/t0P:positive regulation of proteasomal ubiquiti...sq~Z&/tP:organ morphogenesissq~Z%/t$P:anatomical structure morphogenesissq~Z$/tP:response to UVsq~ZN/t0P:long-term strengthening of neuromuscular ju...sq~Z ]/t+P:negative regulation of cell proliferationsq~ZU/tP:regulation of phosphorylationsq~Z_/tP:striated muscle developmentsq~Z]/tP:muscle developmentsq~Zws/t0P:ubiquitin-dependent SMAD protein catabolic ...sq~Z/tP:nucleosome assemblysq~Z/tP:mismatch repairsq~Zz/t0P:negative regulation of transcription from R...sq~Z@/tP:protein modification processsq~Z/t!P:pigmentation during developmentsq~Z'/t#P:regulation of synaptic plasticitysq~Z /t0P:positive regulation of T cell cytokine prod...sq~Z /tP:B cell lineage commitmentsq~Z3/tP:neural tube closuresq~Z/tP:neural crest cell migrationsq~ZƤ/t#P:T cell receptor signaling pathwaysq~Zƶ/t*P:positive regulation of T cell activationsq~Zɔ/tP:protein maturationsq~Zx/t0P:positive regulation of transcription from R...sq~Zu/t&P:positive regulation of transcriptionsq~Z/t0P:proteasomal ubiquitin-dependent protein cat...sq~Z/t0P:positive regulation of gene-specific transc...sq~Z=/t.P:negative regulation of programmed cell deathsq~Z:/t"P:negative regulation of apoptosissq~Z/t0P:negative regulation of transcription factor...sq~Z?/t0P:positive regulation of non-apoptotic progra...sq~Z/t0P:negative regulation of cyclin-dependent pro...sq~Z/tP:base-excision repairsq~ZE/t0P:positive regulation of transcription, DNA-d...sq~Z/tF:protein bindingsq~ZA/tF:ATPase activitysq~Zw/tF:protein binding, bridgingsq~Z/t#F:ubiquitin-protein ligase activitysq~Z/t$F:transcription coactivator activitysq~Zy/t0F:RNA polymerase II transcription factor acti...sq~Zq/tF:single-stranded DNA bindingsq~Z{+/t0F:thyrotropin-releasing hormone receptor bindingsq~Z}/t,F:dinucleotide insertion or deletion bindingsq~Zx/tF:TPR domain bindingsq~Z/t%F:protein heterodimerization activitysq~Zʧ/tF:Hsp90 protein bindingsq~Z/tF:SMAD bindingsq~Z3/t#F:protein homodimerization activitysq~ZwP/tF:Hsp70 protein bindingsq~Z/t!F:transcription cofactor activitysq~Z/tF:signal transducer activitysq~Zb/tF:chromatin bindingsq~Zt/tF:transcription factor activitysq~Z/t$F:transcription corepressor activitysq~Z/t F:RNA bindingsq~ZO/tF:endopeptidase activitysq~Z/t0F:cyclin-dependent protein kinase inhibitor a...sq~Z!Z/tF:proteasome activator activitysq~Z</t)F:oxoglutarate:malate antiporter activitysq~Z/t0F:purine-specific mismatch base pair DNA N-gl...sq~Zw@/t"F:transcription regulator activitysq~Zv|/tF:cyclin bindingsq~Zu/t(F:Hsp70/Hsc70 protein inhibitor activitysq~ZM/tF:kinase bindingsq~Z@/t-F:specific transcriptional repressor activitysq~Z@/t"F:transcription repressor activitysq~Z@/t"F:transcription activator activitysq~Z/t&C:proteasome complex (sensu Eukaryota)sq~Z /t C:nucleussq~Z/t0C:proteasome regulatory particle (sensu Eukar...sq~Zi/t C:cytoplasmsq~Z/tC:integral to plasma membranesq~ZW/t!C:perinuclear region of cytoplasmsq~Z/t C:chromatinsq~Z/tC:membrane fractionsq~Zz/t&C:ubiquitin conjugating enzyme complexsq~Z~-/tC:MutSalpha complexsq~Z;/t C:MCM complexsq~Z/t+C:proteasome core complex (sensu Eukaryota)sq~Z/t C:cytosolsq~Zo/tC:mitochondrial inner membranesq~Z./tC:chromatin assembly complexsq~Z/tC:protein complexsq~Z#/tC:transcription factor complexsq~Z3/t0C:cyclin-dependent protein kinase holoenzyme ...ppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~/tF:protein bindingt5515sq~/t&C:proteasome complex (sensu Eukaryota)t502ppppppppxsq~uq~ sq~/t IPR014474t26S_protsm_RPN10sq~/t IPR003903tUIMsq~/t IPR002035tVWF_Apppppppxsq~uq~ sq~/tUIMtPF02809pppppppppxtP55036t PSMD4_HUMANsq~uq~ sq~/t%26S proteasome regulatory subunit S5Asq~/tRpn10sq~/t$Multiubiquitin chain-binding proteinsq~/tAntisecretory factor 1sq~/tAFsq~/tASFppppxt Homo sapienstFANCGsq~P?%tFanconi anemia group G proteinsq~uq~ sq~UtENSG00000165280pppppppppxsq~uq~ sq~mtFANCGsq~mtXRCC9ppppppppxsq~1uq~ Psq~Zt P:DNA repairsq~Z=tP:protein complex assemblysq~ZJt.P:regulation of progression through cell cyclesq~ZtP:signal transductionsq~Zt-P:regulation of S phase of mitotic cell cyclesq~Zt0P:regulation of transcription from RNA polyme...sq~ZtP:nucleotide-excision repairsq~ZtP:double-strand break repairsq~ZtP:DNA recombinationsq~Zt,P:regulation of transcription, DNA-dependentsq~ZtP:anti-apoptosissq~Z&tP:steroid biosynthetic processsq~Z@t0P:negative regulation of mammary gland epithe...sq~ZtP:cytokinesis during cell cyclesq~ZtP:sarcomere organizationsq~ZktP:response to estrogen stimulussq~Z;tP:response to genisteinsq~ZbtP:centrosome duplicationsq~Z tF:protein bindingsq~ZPt(F:structural constituent of cytoskeletonsq~ZMqtF:oxygen bindingsq~ZtF:gamma-tubulin bindingsq~Z@t"F:transcription activator activitysq~ZutF:PDZ domain bindingsq~Z st"F:structural constituent of musclesq~Z tF:aromatase activitysq~Z#_tF:electron carrier activitysq~ZUt*F:cyclin-dependent protein kinase activitysq~ZtF:transposase activitysq~ZtF:signal transducer activitysq~ZtF:monooxygenase activitysq~ZtF:actin bindingsq~ZttF:transcription factor activitysq~Zt C:nucleussq~ZtC:membrane fractionsq~Zt C:costameresq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZtC:nuclear chromosomesq~Z9tC:BRCA2-MAGE-D1 complexsq~ZtC:intermediate filamentsq~Zw t C:midbodysq~Zut,C:integral to endoplasmic reticulum membranesq~Zit C:cytoplasmsq~ZtC:endoplasmic reticulumsq~Zt C:centrosomesq~Zt C:spectrinsq~Zt C:cytosolsq~ZtC:spindle microtubulesq~ZutC:secretory granulepppppppppppppppppppppppppppppppxsq~uq~ sq~tP:cell cycle checkpointt75sq~t P:DNA repairt6281sq~tF:damaged DNA bindingt3684pppppppxsq~uq~ sq~t IPR011990tTPR-like_helicalsq~t IPR013026t TPR_regionppppppppxptO15287t FANCG_HUMANsq~uq~ sq~t Protein FACGsq~tDNA-repair protein XRCC9ppppppppxt Homo sapienstPSMD6sq~P?ΓΎ4Q4%t.26S proteasome non-ATPase regulatory subunit 6sq~uq~ sq~UQtENSG00000163636pppppppppxsq~uq~ sq~mQtPSMD6sq~mQtKIAA0107sq~mQtPFAAP4pppppppxsq~Tuq~ sq~ZQtP:signal transductionsq~ZoQt/P:ubiquitin-dependent protein catabolic processsq~ZDQt$P:protein amino acid phosphorylationsq~Z&QtP:response to stresssq~ZQtP:induction of apoptosissq~ZlQt P:proteolysissq~Z.Qt(P:regulation of translational initiationsq~ZsQt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZQt/P:transcription from RNA polymerase II promotersq~ZQtP:male meiosis Isq~ZJQtP:response to unfolded proteinsq~Z+QtP:immune responsesq~ZQtP:sodium ion transportsq~ZQtP:muscle contractionsq~ZQtP:cell motilitysq~Z9QtP:protein foldingsq~ZQt P:apoptosissq~ZQtP:anti-apoptosissq~Z QtP:translational initiationsq~ZQtP:electron transportsq~ZQtP:nucleotide-excision repairsq~ZQtP:potassium ion transportsq~ZRQt)P:activation of NF-kappaB-inducing kinasesq~ZJQt.P:regulation of progression through cell cyclesq~Z*QtP:inflammatory responsesq~Z=Qt.P:negative regulation of programmed cell deathsq~ZQt0P:proteasomal ubiquitin-dependent protein cat...sq~ZQt0P:positive regulation of gene-specific transc...sq~ZƤQt#P:T cell receptor signaling pathwaysq~Z Qt0P:positive regulation of T cell cytokine prod...sq~ZƶQt*P:positive regulation of T cell activationsq~ZQtP:mitotic cell cyclesq~ZQtP:protein polyubiquitinationsq~ZyQt,P:regulation of centriole-centriole cohesionsq~ZxQt!P:epithelial cell differentiationsq~ZVQt P:JNK cascadesq~ZsQtP:spermatogenesissq~Z]QtP:muscle developmentsq~ZQtP:sensory perception of soundsq~ZPQt!P:regulation of heart contractionsq~ZQtP:mammary gland involutionsq~Z!`QtP:epidermis developmentsq~Z$Qt0P:folic acid and derivative biosynthetic processsq~Z$QtF:protein bindingsq~ZAQtF:ATPase activitysq~ZQt F:RNA bindingsq~ZQt F:ATP bindingsq~ZBQt*F:protein serine/threonine kinase activitysq~ZQt$F:transcription coactivator activitysq~ZQt!F:transcription cofactor activitysq~ZQt0F:methylenetetrahydrofolate dehydrogenase (NA...sq~Z}Qt0F:methenyltetrahydrofolate cyclohydrolase act...sq~Z@Qt"F:transcription repressor activitysq~ZQt*F:formate-tetrahydrofolate ligase activitysq~ZMQtF:protein kinase bindingsq~ZuQtF:chaperone regulator activitysq~ZqQtF:single-stranded DNA bindingsq~Zw,Qt0F:thiol-disulfide exchange intermediate activitysq~ZtQtF:transcription factor activitysq~ZOQtF:endopeptidase activitysq~ZQt$F:structural constituent of ribosomesq~Z{+Qt0F:thyrotropin-releasing hormone receptor bindingsq~ZQt$F:transcription corepressor activitysq~ZwQtF:protein binding, bridgingsq~Z`Qt$F:NF-kappaB-inducing kinase activitysq~ZQt.F:delayed rectifier potassium channel activitysq~Z_QtF:transporter activitysq~ZQtF:receptor activitysq~ZQtF:signal transducer activitysq~ZQt#F:ubiquitin-protein ligase activitysq~ZQt&C:proteasome complex (sensu Eukaryota)sq~ZQt C:nucleussq~ZQt0C:proteasome regulatory particle (sensu Eukar...sq~ZiQt C:cytoplasmsq~ZQtC:cytoskeletonsq~ZQt C:polysomesq~ZQt+C:proteasome core complex (sensu Eukaryota)sq~ZQt C:cytosolsq~ZQt C:centrosomesq~ZQt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZyQt0C:mitochondrial proton-transporting ATP synth...sq~Z=QtC:microtubule cytoskeletonsq~Z'QtC:cell surfacesq~ZQt)C:voltage-gated potassium channel complexppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~QtP:ATP-dependent proteolysist6510sq~QtF:ATPase activityt16887sq~QtF:protein bindingt5515sq~Qt&C:proteasome complex (sensu Eukaryota)t502ppppppxsq~uq~ sq~Qt IPR000717tPCIpppppppppxsq~uq~ sq~QtPCItPF01399pppppppppxtQ15008t PSMD6_HUMANsq~uq~ sq~Qt%26S proteasome regulatory subunit S10sq~Qtp42Asq~Qt-Proteasome regulatory particle subunit p44S10sq~Qt,Phosphonoformate immuno-associated protein 4sq~Qt)Breast cancer-associated protein SGA-113Mpppppxt Homo sapienstFANCAsq~P?cHx89%tFanconi anemia group A proteinsq~uq~ sq~UtENSG00000187741pppppppppxsq~uq~ sq~mtFANCAsq~mtFAAsq~mtFACAsq~mtFANCHppppppxsq~uq~ @sq~ZtP:anti-apoptosissq~Zt0P:regulation of transcription from RNA polyme...sq~Zt P:DNA repairsq~ZEt0P:positive regulation of transcription, DNA-d...sq~ZDt$P:protein amino acid phosphorylationsq~ZtP:signal transductionsq~ZJtP:response to unfolded proteinsq~Zw9t%P:androgen receptor signaling pathwaysq~Zt0P:G-protein coupled receptor protein signalin...sq~ZtP:DNA recombinationsq~Z@at&P:negative regulation of transcriptionsq~ZtP:striated muscle contractionsq~Z&tP:response to stresssq~Z(tP:defense responsesq~Z+tP:immune responsesq~ZBt0P:DNA damage response, signal transduction by...sq~ZCtP:response to oxidative stresssq~ZYt0P:chromosome organization and biogenesis (sen...sq~ZgtP:actin filament organizationsq~ZmtP:tubulin foldingsq~ZtP:chromosome segregationsq~Zt P:meiosissq~ZtP:induction of apoptosissq~Z tP:activated T cell apoptosissq~Zt0P:regulation of transcription from RNA polyme...sq~Zt/P:transcription from RNA polymerase II promotersq~ZtP:mRNA export from nucleussq~Z t P:translationsq~Z9tP:protein foldingsq~Z=tP:protein complex assemblysq~ZYtP:protein homotetramerizationsq~ZtP:lipid metabolic processsq~Zt#P:nitric oxide biosynthetic processsq~ZtP:sodium ion transportsq~ZtP:calcium ion transportsq~ZtP:mitochondrial transportsq~Zt"P:cellular calcium ion homeostasissq~ZJt!P:intracellular signaling cascadesq~ZKtP:protein kinase cascadesq~ZttP:B cell proliferationsq~Zt"P:regulation of cell proliferationsq~ZtP:fibrinolysissq~ZktP:response to estrogen stimulussq~Zt0P:negative regulation of fatty acid biosynthe...sq~Zt#P:positive regulation of DNA repairsq~ZtP:regulation of angiogenesissq~ZDt0P:negative regulation of transcription, DNA-d...sq~Zt0P:positive regulation of dopamine metabolic p...sq~Zt P:hypoxanthine metabolic processsq~Zt.P:negative regulation of centriole replicationsq~Zt(P:protein amino acid autophosphorylationsq~Zt0P:insulin-like growth factor receptor signali...sq~Zƥt#P:B cell receptor signaling pathwaysq~Zǔt.P:activation of NF-kappaB transcription factorsq~Z*tP:protein refoldingsq~Zzt/P:positive regulation of protein ubiquitinationsq~ZTtP:I-kappaB phosphorylationsq~ZYtP:activation of JNK activitysq~ZctP:cell-cell signalingsq~Zt P:behaviorsq~Z \t+P:positive regulation of cell proliferationsq~Z ^t$P:insulin receptor signaling pathwaysq~Z!`tP:epidermis developmentsq~Z!t0P:induction of apoptosis via death domain rec...sq~Z!t0P:DNA damage response, signal transduction re...sq~Z$tP:response to heatsq~Z%t$P:anatomical structure morphogenesissq~Z:tP:protein transportsq~ZFt!P:peptidyl-serine phosphorylationsq~ZutP:B cell differentiationsq~Zvdt$P:negative regulation of cell growthsq~ZtP:sequestering of calcium ionsq~ZtP:chromatin remodelingsq~ZtP:postreplication repairsq~Zt0P:double-strand break repair via homologous r...sq~Zt(P:nuclear mRNA splicing, via spliceosomesq~ZKt'P:complement activation, lectin pathwaysq~Zzt0P:negative regulation of transcription from R...sq~Z<t,P:protein import into nucleus, translocationsq~Z_t-P:assembly of spliceosomal tri-snRNP U4/U6.U5sq~ZtP:response to hypoxiasq~ZKtP:cell cycle checkpointsq~ZJt.P:regulation of progression through cell cyclesq~ZtP:nucleotide-excision repairsq~Zut0P:positive regulation of nitric oxide biosynt...sq~ZutP:DNA-dependent DNA replicationsq~ZptP:fructose metabolic processsq~Zt P:glycolysissq~Zt(P:purine nucleotide biosynthetic processsq~ZtP:purine ribonucleoside salvagesq~ZtF:protein bindingsq~Z2tF:identical protein bindingsq~Zt$F:transcription coactivator activitysq~Zt F:ATP bindingsq~ZBt*F:protein serine/threonine kinase activitysq~ZPt(F:structural constituent of cytoskeletonsq~Z}tF:protein N-terminus bindingsq~ZtF:androgen receptor bindingsq~Zvt0F:RNA polymerase II transcription factor acti...sq~Z3t#F:protein homodimerization activitysq~ZtF:calcium ion bindingsq~Zt F:RNA bindingsq~Z NtF:zinc ion bindingsq~ZNJtF:unfolded protein bindingsq~Z]t F:DNA bindingsq~ZttF:transcription factor activitysq~ZxtF:TPR domain bindingsq~Zy`tF:heat shock protein bindingsq~Zt$F:structural constituent of ribosomesq~Zvt*F:nitric-oxide synthase regulator activitysq~ZMtF:enzyme bindingsq~ZTtF:GTPase activitysq~Z@t"F:transcription repressor activitysq~Z@t"F:transcription activator activitysq~ZtF:sugar bindingsq~Zt"F:nuclear hormone receptor bindingsq~ZdtF:damaged DNA bindingsq~ZtF:magnesium ion bindingsq~ZqtF:single-stranded DNA bindingsq~ZtF:virion bindingsq~Z tF:ribonucleoprotein bindingsq~ZLtF:DNA topoisomerase activitysq~Z>t*F:low-density lipoprotein receptor bindingsq~ZGtF:actin filament bindingsq~Zt$F:transcription corepressor activitysq~Zt%F:ATP-dependent DNA helicase activitysq~Z=tF:tubulin bindingsq~Zt F:GTP bindingsq~Zt$F:phosphopyruvate hydratase activitysq~Z tF:IkappaB kinase activitysq~ZUt*F:cyclin-dependent protein kinase activitysq~ZtF:actin bindingsq~Z_tF:transporter activitysq~ZVtF:protein C-terminus bindingsq~ZtF:enzyme inhibitor activitysq~ZtF:receptor activitysq~Zt%F:receptor signaling protein activitysq~ZtF:cytokine activitysq~Zt F:endodeoxyribonuclease activitysq~Zt%F:ATP-dependent RNA helicase activitysq~Zt)F:fructose-bisphosphate aldolase activitysq~ZFt0F:hypoxanthine phosphoribosyltransferase acti...sq~Z# tF:phospholipase A1 activitysq~Z"tF:helicase activitysq~Z t C:nucleussq~Zit C:cytoplasmsq~Zt C:cytosolsq~ZWt!C:perinuclear region of cytoplasmsq~Z@tC:SWI/SNF complexsq~ZtC:multivesicular bodysq~ZtC:membrane fractionsq~Zt C:spectrinsq~Zzt0C:mitochondrial proton-transporting ATP synth...sq~ZtC:endoplasmic reticulum lumensq~ZtC:integral to plasma membranesq~Zt C:endoplasmic reticulum membranesq~Zt C:microsomesq~Zt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Zmt$C:nucleotide-excision repair complexsq~ZtC:cytoskeletonsq~ZtC:spindle microtubulesq~ZtC:intermediate filamentsq~ZtC:plasma membranesq~ZtC:U4/U6 x U5 tri-snRNP complexsq~Z%t$C:transcription factor TFIID complexsq~Z:t C:Cajal bodysq~Z&t"C:external side of plasma membranesq~Z@t C:PML bodysq~ZMgtC:B cell receptor complexsq~Z RtC:gamma-tubulin ring complexsq~Zw t C:midbodysq~ZztC:BRCA1-BARD1 complexsq~Z@tC:nuclear specksq~ZAt C:lipid raftsq~ZtC:extracellular spacesq~Zt C:nucleoplasmsq~Zt"C:DNA replication factor A complexsq~Zt&C:proteasome complex (sensu Eukaryota)sq~Z>t C:membranepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~t P:DNA repairt6281sq~tP:protein complex assemblyt6461sq~tF:protein bindingt5515sq~t C:cytoplasmt5737sq~t C:nucleust5634pppppxsq~uq~ sq~t IPR003516tFanconiapppppppppxsq~uq~ sq~t Fanconi_AtPF03511pppppppppxtO15360t FANCA_HUMANsq~uq~ sq~t Protein FACApppppppppxt Homo sapienstEGR1sq~P?//%tEarly growth response protein 1sq~uq~ sq~UtENSG00000120738pppppppppxsq~uq~ sq~mtEGR1sq~mtZNF225ppppppppxsq~Puq~ Psq~Zt,P:regulation of transcription, DNA-dependentsq~ZtP:signal transductionsq~Z`tP:homeostatic processsq~Z [tP:cell proliferationsq~ZtP:nervous system developmentsq~ZFt(P:N-terminal peptidyl-lysine acetylationsq~ZtP:response to hypoxiasq~Zut&P:positive regulation of transcriptionsq~Zt P:cell agingsq~ZtP:protein localizationsq~ZɗtP:defense response to virussq~Zkt&P:multicellular organismal developmentsq~ZtP:cell cycle arrestsq~ZGtP:ER overload responsesq~Z8tP:cellular defense responsesq~Z+tP:immune responsesq~Z*tP:inflammatory responsesq~Z!t%P:caspase activation via cytochrome csq~Z%t$P:anatomical structure morphogenesissq~Z'1tP:response to organic substancesq~Z>tP:protein tetramerizationsq~ZǙt*P:negative regulation of helicase activitysq~Zǔt.P:activation of NF-kappaB transcription factorsq~ZǓt0P:positive regulation of transcription factor...sq~Z6t0P:regulation of mitochondrial membrane permea...sq~Zt0P:positive regulation of global transcription...sq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~Zt0P:DNA damage response, signal transduction by...sq~Zt)P:cellular response to glucose starvationsq~ZKt0P:cytokine and chemokine mediated signaling p...sq~Z@tP:histone acetylationsq~Z'tP:response to UV-Bsq~Z)tP:acute-phase responsesq~ZtP:anti-apoptosissq~Zvdt$P:negative regulation of cell growthsq~ZtP:skeletal developmentsq~ZtP:base-excision repairsq~ZtP:nucleotide-excision repairsq~Zt/P:transcription from RNA polymerase II promotersq~Z=tP:protein complex assemblysq~ZDt$P:protein amino acid phosphorylationsq~Zt P:apoptosissq~ZttF:transcription factor activitysq~ZtF:protein bindingsq~Z}tF:protein N-terminus bindingsq~Zt$F:transcription coactivator activitysq~Zvt0F:RNA polymerase II transcription factor acti...sq~Z2t$F:histone acetyltransferase activitysq~Z@t"F:transcription activator activitysq~ZtF:signal transducer activitysq~ZVtF:protein C-terminus bindingsq~Z2tF:identical protein bindingsq~Z3t#F:protein homodimerization activitysq~Z-tF:sequence-specific DNA bindingsq~Zyt0F:RNA polymerase II transcription factor acti...sq~Zt F:ATP bindingsq~Zt%F:protein heterodimerization activitysq~ZstF:NF-kappaB bindingsq~Z=tF:phosphate bindingsq~ZtF:DNA strand annealing activitysq~ZytF:MyoD bindingsq~Zt$F:transcription corepressor activitysq~Z NtF:zinc ion bindingsq~ZtF:copper ion bindingsq~ZMtF:enzyme bindingsq~ZMtF:protein kinase bindingsq~ZJtF:protein kinase CK2 activitysq~ZtF:nuclease activitysq~Z@t"F:transcription repressor activitysq~Zt C:nucleussq~Zit C:cytoplasmsq~ZtC:insoluble fractionsq~Zt&C:proteasome complex (sensu Eukaryota)sq~ZtC:plasma membranesq~Zt C:nucleoplasmsq~ZktC:mitochondrionsq~Z?tC:nuclear matrixsq~Z#tC:transcription factor complexsq~Zbt C:nucleolussq~ZtC:nuclear chromosomexsq~uq~ sq~t&P:positive regulation of transcriptiont45941sq~tF:transcription factor activityt3700sq~t C:nucleust5634pppppppxsq~uq~ sq~t IPR007087tZnf_C2H2pppppppppxsq~uq~ sq~tzf-C2H2tPF00096pppppppppxtP18146t EGR1_HUMANsq~uq~ sq~tEGR-1sq~tProtein Krox-24sq~tTranscription factor Zif268sq~t%Nerve growth factor-induced protein Asq~tNGFI-Asq~tTranscription factor ETR103sq~tZinc finger protein 225sq~tAT225ppxt Homo sapienstSGK1sq~P?|( />P>%t$Serine/threonine-protein kinase Sgk1sq~uq~ sq~UPtENSG00000118515pppppppppxsq~uq~ sq~mPtSGKsq~mPtSGK1ppppppppxsq~uq~ @sq~ZPtP:signal transductionsq~Z=PtP:protein complex assemblysq~ZDPt$P:protein amino acid phosphorylationsq~Z [PtP:cell proliferationsq~Z@PtP:protein ubiquitinationsq~ZsPt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z:PtP:protein transportsq~ZPtP:translational elongationsq~Z.Pt(P:regulation of translational initiationsq~ZIPt!P:actin filament bundle formationsq~ZPt P:apoptosissq~Z+PtP:immune responsesq~ZPt(P:nuclear mRNA splicing, via spliceosomesq~ZPt P:excretionsq~ZPt!P:cellular sodium ion homeostasissq~ZPtP:anti-apoptosissq~ZPtP:induction of apoptosissq~ZPtP:caspase activationsq~Z&PtP:response to stresssq~Z*PtP:inflammatory responsesq~Z/PtP:humoral immune responsesq~ZGPtP:ER overload responsesq~ZPtP:sodium ion transportsq~ZPtP:potassium ion transportsq~ZPt+P:NLS-bearing substrate import into nucleussq~ZvPtP:glucose metabolic processsq~ZPt P:glycolysissq~Z-Pt$P:'de novo' IMP biosynthetic processsq~ZtPtP:DNA replicationsq~ZPt P:DNA repairsq~ZPtP:double-strand break repairsq~ZPtP:transcription, DNA-dependentsq~ZPtP:mRNA polyadenylationsq~ZPtP:RNA processingsq~Z Pt P:translationsq~Z PtP:translational initiationsq~ZnPtP:ATP-dependent proteolysissq~ZoPt/P:ubiquitin-dependent protein catabolic processsq~ZPtP:protein targetingsq~ZhPtP:cytoskeletal anchoringsq~ZPt P:cell cyclesq~ZPtP:cell cycle arrestsq~ZxPt-P:retrograde protein transport, ER to cytosolsq~ZyPt0P:positive regulation of microtubule polymeri...sq~ZtPtP:B cell proliferationsq~ZPt)P:regulation of protein catabolic processsq~ZPtP:histone exchangesq~ZPPt0P:positive regulation of erythrocyte differen...sq~ZPt'P:positive regulation of axon extensionsq~ZPt$P:positive regulation of endocytosissq~Z#Pt'P:regulation of protein kinase activitysq~ZDPt0P:negative regulation of transcription, DNA-d...sq~ZuPt&P:positive regulation of transcriptionsq~ZxPt0P:positive regulation of transcription from R...sq~ZPt(P:protein amino acid autophosphorylationsq~ZPt0P:positive regulation of protein export from ...sq~ZxPtP:unfolded protein responsesq~ZvPt)P:ER-associated protein catabolic processsq~ZuPtP:platelet activationsq~ZPtP:chromosome segregationsq~Z=PtP:glutamate transportsq~ZJPt!P:intracellular signaling cascadesq~ZkPt&P:multicellular organismal developmentsq~Z ^Pt$P:insulin receptor signaling pathwaysq~Z#Pt"P:purine base biosynthetic processsq~Z&PtP:organ morphogenesissq~Z'6PtP:response to metal ionsq~ZPt0P:Wnt receptor signaling pathway through beta...sq~ZFPt!P:peptidyl-serine phosphorylationsq~ZM PtP:calcium-mediated signalingsq~ZuTPt0P:actin cytoskeleton organization and biogenesissq~ZuwPt0P:regulation of mitotic metaphase/anaphase tr...sq~ZuPtP:water homeostasissq~ZPtP:mRNA stabilizationsq~ZYPtP:glycogen metabolic processsq~ZWPt P:carbohydrate metabolic processsq~Z:Pt"P:negative regulation of apoptosissq~ZPtP:neurotransmitter uptakesq~Z PtP:blastocyst developmentsq~ZPtP:MAPKKK cascadesq~ZUPt P:G2 phase of mitotic cell cyclesq~ZOPt0P:regulation of cyclin-dependent protein kina...sq~ZHPt&P:M phase specific microtubule processsq~ZPt!P:regulation of DNA recombinationsq~Z PtF:protein bindingsq~ZPt F:RNA bindingsq~ZPt F:ATP bindingsq~ZtPtF:transcription factor activitysq~ZPt$F:structural constituent of ribosomesq~ZMPtF:enzyme bindingsq~ZPtF:calcium ion bindingsq~ZPtF:calmodulin bindingsq~ZAPtF:ATPase activitysq~ZPt(F:translation elongation factor activitysq~ZBPt#F:sodium channel regulator activitysq~Z-PtF:sequence-specific DNA bindingsq~Z"Pt0F:phosphoribosylformylglycinamidine synthase ...sq~Z@Pt"F:transcription activator activitysq~ZePtF:protein self-associationsq~Z@PtF:protein kinase activitysq~ZBPt*F:protein serine/threonine kinase activitysq~ZDPt0F:3-phosphoinositide-dependent protein kinase...sq~ZPt0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~ZXPt%F:glycogen synthase kinase 3 activitysq~ZcPtF:MAP kinase activitysq~Z!.Pt F:translation activator activitysq~ZBPt$F:nucleoside-triphosphatase activitysq~ZPt!F:transcription cofactor activitysq~ZPt(F:translation initiation factor activitysq~ZPtF:actin bindingsq~ZPtF:RNA helicase activitysq~ZPtF:antigen bindingsq~ZPt%F:carbonyl reductase (NADPH) activitysq~Z2PtF:identical protein bindingsq~ZOPtF:endopeptidase activitysq~ZMPtF:protein kinase bindingsq~ZVPtF:protein C-terminus bindingsq~Z Pt F:citrate (Si)-synthase activitysq~ZPt$F:serine-type endopeptidase activitysq~Z Pt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZiPt"F:protein-tyrosine kinase activitysq~ZPt0F:[pyruvate dehydrogenase (lipoamide)] kinase...sq~ZPtF:poly(A) bindingsq~ZPt)F:Rab GDP-dissociation inhibitor activitysq~ZPPt(F:structural constituent of cytoskeletonsq~Z_PtF:transporter activitysq~ZPtF:magnesium ion bindingsq~ZPt0F:L-glutamate transmembrane transporter activitysq~ZGPtF:actin filament bindingsq~ZsPtF:NF-kappaB bindingsq~ZNJPtF:unfolded protein bindingsq~ZWPt F:NAD bindingsq~ZʧPtF:Hsp90 protein bindingsq~ZBPtF:SH3 domain bindingsq~ZPt!F:transmembrane receptor activitysq~ZPtF:receptor activitysq~ZPt'F:nuclear localization sequence bindingsq~ZPt0F:translation factor activity, nucleic acid b...sq~ZbPtF:lipoprotein bindingsq~ZPt F:p53 bindingsq~ZQPtF:microtubule bindingsq~ZzPt-F:inward rectifier potassium channel activitysq~ZPtF:signal transducer activitysq~ZPt#F:ubiquitin-protein ligase activitysq~ZPtF:valine-tRNA ligase activitysq~Zi Pt C:cytoplasmsq~Z Pt C:nucleussq~ZPtC:integral to plasma membranesq~ZPt C:cytosolsq~ZPtC:plasma membranesq~ZPtC:intracellularsq~ZPt0C:eukaryotic translation initiation factor 3 ...sq~ZPt C:nucleoplasmsq~Z1Pt C:spliceosomesq~ZPtC:endoplasmic reticulumsq~ZkPtC:mitochondrionsq~ZPt&C:proteasome complex (sensu Eukaryota)sq~Z'PtC:cell surfacesq~ZPt)C:voltage-gated potassium channel complexsq~ZPt C:microtubule associated complexsq~ZxPt"C:beta-catenin destruction complexsq~ZPtC:actin filamentsq~ZyPt0C:mitochondrial proton-transporting ATP synth...sq~ZPt C:microvillussq~ZbPt C:nucleolussq~ZPtC:extracellular regionsq~ZPtC:membrane fractionsq~ZPtC:mitochondrial matrixsq~ZPtC:rufflesq~ZxPtC:cortical cytoskeletonsq~ZwBPt0C:heterogeneous nuclear ribonucleoprotein com...sq~ZvPt C:growth conesq~ZvPtC:axonsq~ZPt+C:proteasome core complex (sensu Eukaryota)sq~ZPt C:microsomesq~ZMPtC:extrinsic to membranesq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~Z>Pt C:membranesq~ZPtC:tubulin complexsq~Z= PtC:actin cytoskeletonsq~ZPt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZPtC:soluble fractionppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Pt$P:protein amino acid phosphorylationt6468sq~PtP:response to stresst6950sq~PtP:sodium ion transportt6814sq~PtF:protein bindingt5515sq~Pt*F:protein serine/threonine kinase activityt4674pppppxsq~uq~ sq~Pt IPR000961t Pkinase_Csq~Pt IPR000719tProt_kinase_coresq~Pt IPR008271tSer_thr_pkin_ASsq~Pt IPR002290tSer_thr_pkinaseppppppxsq~uq~ sq~PtPkinasetPF00069sq~Pt Pkinase_CtPF00433ppppppppxtO00141t SGK1_HUMANsq~uq~ sq~Pt'Serum/glucocorticoid-regulated kinase 1pppppppppxt Homo sapienstCCNHsq~P?^N0%tCyclin-Hsq~uq~ sq~U0tENSG00000134480pppppppppxsq~uq~ sq~m0tCCNHpppppppppxsq~euq~ sq~Z [0tP:cell proliferationsq~Z0tP:signal transductionsq~ZO0t0P:regulation of cyclin-dependent protein kina...sq~Z0t/P:transcription from RNA polymerase II promotersq~Z0t,P:regulation of transcription, DNA-dependentsq~Z0tP:nucleotide-excision repairsq~Z0t0P:transcription initiation from RNA polymeras...sq~Z0t P:DNA repairsq~Z \0t+P:positive regulation of cell proliferationsq~Z0t P:mitosissq~Z0t0P:traversing start control point of mitotic c...sq~Z!0t%P:caspase activation via cytochrome csq~ZJ0t!P:intracellular signaling cascadesq~Z>0t!P:response to DNA damage stimulussq~Z0tP:cell cycle arrestsq~ZG0tP:ER overload responsesq~Z0tP:induction of apoptosissq~Z0t!P:intracellular protein transportsq~Z0t P:transportsq~ZD0t$P:protein amino acid phosphorylationsq~ZU0tP:regulation of phosphorylationsq~Z=0tP:protein complex assemblysq~Zc0tP:cell-cell signalingsq~Zk0t&P:multicellular organismal developmentsq~Z60t0P:regulation of mitochondrial membrane permea...sq~ZE0t0P:positive regulation of transcription, DNA-d...sq~Z0t0P:DNA damage response, signal transduction by...sq~Z0t)P:cellular response to glucose starvationsq~Zx0tP:prostate gland developmentsq~Zw90t%P:androgen receptor signaling pathwaysq~Zw80t%P:estrogen receptor signaling pathwaysq~Zvd0t$P:negative regulation of cell growthsq~Zv 0tP:erythrocyte differentiationsq~Z>0tP:protein tetramerizationsq~Z>0t P:cell growthsq~Z%0tP:response to hormone stimulussq~Z0tP:protein localizationsq~Z0t P:cell agingsq~Z|0tP:sex differentiationsq~ZS0tP:heart developmentsq~ZǙ0t*P:negative regulation of helicase activitysq~Z0t0P:regulation of transcription from RNA polyme...sq~Z0tP:transcription, DNA-dependentsq~Z#0t0P:positive regulation of tyrosine phosphoryla...sq~ZJ0t.P:regulation of progression through cell cyclesq~ZV0t'P:G2/M transition of mitotic cell cyclesq~Zt0tP:DNA replicationsq~Zy0tP:DNA topological changesq~Z0tP:regulation of DNA replicationsq~Z0t0P:transcription-coupled nucleotide-excision r...sq~Z0tP:base-excision repairsq~Z0tF:protein bindingsq~Zt0tF:transcription factor activitysq~Z N0tF:zinc ion bindingsq~ZU0t*F:cyclin-dependent protein kinase activitysq~Z}0tF:protein N-terminus bindingsq~Zd0tF:damaged DNA bindingsq~Z0t$F:transcription coactivator activitysq~Z@0tF:protein kinase activitysq~Z0tF:motor activitysq~Z0tF:nuclease activitysq~Z?{0t0F:general RNA polymerase II transcription fac...sq~Z0tF:3'-5' DNA helicase activitysq~Z0tF:DNA strand annealing activitysq~ZM0tF:enzyme bindingsq~Zq0tF:single-stranded DNA bindingsq~Z0t F:RNA bindingsq~Zv0t*F:nitric-oxide synthase regulator activitysq~Z20tF:identical protein bindingsq~ZvL0tF:estrogen receptor activitysq~Z 0t(F:RNA polymerase subunit kinase activitysq~Z0tF:androgen receptor bindingsq~Z0tF:protein dimerization activitysq~Z0t%F:protein heterodimerization activitysq~Z0t F:ATP bindingsq~Z0tF:copper ion bindingsq~Z0tF:DNA-dependent ATPase activitysq~Z0tF:androgen receptor activitysq~Z0tF:transcription factor bindingsq~Z0t0F:translation factor activity, nucleic acid b...sq~Zi0t"F:protein-tyrosine kinase activitysq~Zy0tF:androgen bindingsq~Zl0t0F:receptor signaling protein tyrosine kinase ...sq~Z0t C:nucleussq~Z+0tC:holo TFIIH complexsq~Zi0t C:cytoplasmsq~Zw0tC:mediator complexsq~Z0t&C:proteasome complex (sensu Eukaryota)sq~Z@0tC:chromatin remodeling complexsq~Z;0t C:MCM complexsq~Z0t C:chromatinsq~Zk0tC:mitochondrionsq~Zb0t C:nucleolussq~Z0t C:nucleoplasmsq~Z0tC:insoluble fractionsq~Z0tC:membrane fractionsq~Z>0t C:membranesq~Z?0tC:nuclear matrixsq~Z@K0tC:myosin complexsq~Zu0tC:AP-2 adaptor complexsq~Z0t C:polysomepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~0tF:protein bindingt5515sq~0t C:nucleust5634ppppppppxsq~uq~ sq~0t IPR005258tCcl1sq~0t IPR015432tCycHsq~0t IPR006670tCyclinsq~0t IPR006671tCyclin_Nsq~0t IPR013763tCyclin_relatedsq~0t IPR015429tTrans_reg_cyclinppppxsq~uq~ sq~0tCyclin_NtPF00134pppppppppxtP51946t CCNH_HUMANsq~uq~ sq~0tMO15-associated proteinsq~0tp37sq~0tp34pppppppxt Homo sapienstRSMBsq~P??\,06-%t06tC:integral to membranesq~Zb06t C:nucleolussq~Z06t&C:proteasome complex (sensu Eukaryota)ppppxsq~uq~ sq~06tP:RNA splicingt8380sq~06tF:protein bindingt5515sq~06t)C:small nuclear ribonucleoprotein complext30532sq~06t C:spliceosomet5681ppppppxsq~uq~ sq~06t IPR006649tEuk_arc_LSM_coresq~06t IPR001163tLSM_snRNP_coreppppppppxsq~uq~ sq~06tLSMtPF01423pppppppppxtP14678t RSMB_HUMANsq~uq~ sq~06tsnRNP-Bsq~06tSm protein B/B'sq~06t Sm-B/Sm-B'sq~06tSmB/SmB'ppppppxt Homo sapienstESR1sq~P?*K%tEstrogen receptorsq~uq~ sq~UtENSG00000091831pppppppppxsq~uq~ sq~mtESR1sq~mtESRsq~mtNR3A1pppppppxsq~uq~ sq~Zt/P:transcription from RNA polymerase II promotersq~ZtP:signal transductionsq~Zt0P:regulation of transcription from RNA polyme...sq~ZEt0P:positive regulation of transcription, DNA-d...sq~Zw9t%P:androgen receptor signaling pathwaysq~Zt,P:regulation of transcription, DNA-dependentsq~Zx t0P:positive regulation of transcription from R...sq~Zzt0P:negative regulation of transcription from R...sq~ZDt$P:protein amino acid phosphorylationsq~ZJt.P:regulation of progression through cell cyclesq~Zt P:apoptosissq~Z ^t$P:insulin receptor signaling pathwaysq~ZtP:anti-apoptosissq~ZtP:nervous system developmentsq~ZOt0P:regulation of cyclin-dependent protein kina...sq~Zt0P:transcription initiation from RNA polymeras...sq~Z [tP:cell proliferationsq~Zt P:DNA repairsq~Zt0P:cell surface receptor linked signal transdu...sq~Zw8t%P:estrogen receptor signaling pathwaysq~Z&tP:response to stresssq~Zut&P:positive regulation of transcriptionsq~Z=tP:protein complex assemblysq~Zt0P:G-protein coupled receptor protein signalin...sq~Z+tP:immune responsesq~Z@at&P:negative regulation of transcriptionsq~Z@tP:histone acetylationsq~Zat!P:Ras protein signal transductionsq~ZtP:base-excision repairsq~ZtP:transcription, DNA-dependentsq~ZctP:cell-cell signalingsq~ZDt0P:negative regulation of transcription, DNA-d...sq~ZJt!P:intracellular signaling cascadesq~Zut0P:positive regulation of nitric oxide biosynt...sq~ZtP:induction of apoptosissq~ZtP:cell cycle arrestsq~ZStP:heart developmentsq~Zvdt$P:negative regulation of cell growthsq~Zt0P:epidermal growth factor receptor signaling ...sq~Z \t+P:positive regulation of cell proliferationsq~Z ]t+P:negative regulation of cell proliferationsq~ZFt(P:N-terminal peptidyl-lysine acetylationsq~Zt$P:central nervous system developmentsq~ZKtP:protein kinase cascadesq~Zt0P:insulin-like growth factor receptor signali...sq~Z>t P:cell growthsq~Z%tP:response to hormone stimulussq~Zt&P:positive regulation of MAPK activitysq~Z`tP:homeostatic processsq~Zt0P:positive regulation of gene-specific transc...sq~Zt+P:glucocorticoid receptor signaling pathwaysq~ZtP:response to drugsq~ZtP:brain developmentsq~Zot/P:ubiquitin-dependent protein catabolic processsq~ZtP:nucleotide-excision repairsq~Zt"P:regulation of cell proliferationsq~Zzt/P:positive regulation of protein ubiquitinationsq~Zvt'P:positive regulation of cell migrationsq~Z[tP:JAK-STAT cascadesq~Z tP:RNA splicingsq~Z*tP:inflammatory responsesq~Z t0P:transforming growth factor beta receptor si...sq~ZtP:lipid metabolic processsq~ZutP:myeloid cell differentiationsq~Zt0P:positive regulation of epithelial cell prol...sq~Zt0P:transmembrane receptor protein tyrosine kin...sq~Z>tP:protein tetramerizationsq~Zt P:chemotaxissq~ZtP:activation of MAPKKK activitysq~ZǓt0P:positive regulation of transcription factor...sq~ZOt P:protein amino acid methylationsq~ZtP:response to hypoxiasq~ZJtP:response to unfolded proteinsq~ZtP:RNA processingsq~Z-t&P:epithelial to mesenchymal transitionsq~Z@tP:protein modification processsq~Zt(P:protein amino acid autophosphorylationsq~ZEt0P:negative regulation of protein kinase activitysq~ZFt&P:protein amino acid dephosphorylationsq~ZgtP:actin filament organizationsq~Z&t&P:anterior/posterior pattern formationsq~ZHtP:ER-nuclear signaling pathwaysq~Zbt*P:cytoskeleton organization and biogenesissq~Zt P:cell cyclesq~Z tP:gonad developmentsq~Z!tP:male gonad developmentsq~Z%t$P:anatomical structure morphogenesissq~Z$tP:response to heatsq~Z]t+P:mitochondrion organization and biogenesissq~Z$t!P:response to xenobiotic stimulussq~Z!t0P:DNA damage response, signal transduction re...sq~Z!t%P:caspase activation via cytochrome csq~Z$3t!P:cellular response to starvationsq~Z Ut0P:regulation of G-protein coupled receptor pr...sq~ZtP:chromosome segregationsq~Z tP:bile acid metabolic processsq~ZtP:synaptogenesissq~ZdtP:synaptic transmissionsq~ZtP:axonogenesissq~Zkt&P:multicellular organismal developmentsq~ZtP:SMAD protein complex assemblysq~Z"tP:phospholipase C activationsq~Z=t%P:integrin-mediated signaling pathwaysq~ZVt P:JNK cascadesq~Zt0P:regulation of epidermal growth factor recep...sq~ZjtP:sex determinationsq~Z|tP:sex differentiationsq~Zt P:mitosissq~ZtP:cell adhesionsq~Z tP:cholesterol metabolic processsq~ZtP:protein localizationsq~ZtP:blood coagulationsq~ZtP:signal complex assemblysq~Zt P:digestionsq~Zt P:cell agingsq~ZTtP:I-kappaB phosphorylationsq~ZPt0P:positive regulation of erythrocyte differen...sq~Zt"P:phosphoinositide phosphorylationsq~Zt&P:inositol phosphate dephosphorylationsq~Zt$P:phosphoinositide dephosphorylationsq~Z6t0P:regulation of mitochondrial membrane permea...sq~Zt0P:platelet-derived growth factor receptor sig...sq~Zt0P:nerve growth factor receptor signaling pathwaysq~Zt%P:phosphoinositide-mediated signalingsq~Zt0P:chromatin-mediated maintenance of transcrip...sq~Zt.P:negative regulation of centriole replicationsq~Zt-P:positive regulation of fatty acid oxidationsq~Zt P:positive regulation of mitosissq~Z`t&P:regulation of neuron differentiationsq~Zt0P:negative regulation of fatty acid biosynthe...sq~Zt(P:positive regulation of gluconeogenesissq~Zt0P:negative regulation of cyclin-dependent pro...sq~Zt#P:positive regulation of DNA repairsq~ZtP:regulation of angiogenesissq~Zt0P:negative regulation of progression through ...sq~Zt0P:positive regulation of global transcription...sq~Z't#P:regulation of synaptic plasticitysq~Zt!P:paraxial mesoderm morphogenesissq~Zt0P:negative regulation of smooth muscle cell d...sq~Zt!P:protein insertion into membranesq~Z t0P:release of sequestered calcium ion into cyt...sq~ZetP:cell divisionsq~Zvt P:G1 phasesq~ZɔtP:protein maturationsq~ZɗtP:defense response to virussq~Zʷt0P:negative regulation of focal adhesion forma...sq~ZǚtP:regulation of bindingsq~ZǙt*P:negative regulation of helicase activitysq~Zǔt.P:activation of NF-kappaB transcription factorsq~Z*t0P:regulation of peptidyl-tyrosine phosphoryla...sq~ZƅtP:protein stabilizationsq~ZƤt#P:T cell receptor signaling pathwaysq~Zƥt#P:B cell receptor signaling pathwaysq~ZƮt0P:positive regulation of T cell receptor sign...sq~Zƶt*P:positive regulation of T cell activationsq~Zƹt P:brown fat cell differentiationsq~Z7t.P:regulation of nitric-oxide synthase activitysq~Zʺt0P:negative regulation of protein kinase B sig...sq~Z'1tP:response to organic substancesq~Zv tP:T cell differentiationsq~Zv]tP:cholesterol transportsq~ZvntP:melanocyte differentiationsq~ZvutP:adrenal gland developmentsq~Zvt'P:negative regulation of cell migrationsq~Zwst0P:ubiquitin-dependent SMAD protein catabolic ...sq~ZxtP:prostate gland developmentsq~ZxtP:mammary gland developmentsq~ZVt/P:negative regulation of dendrite morphogenesissq~Zut P:hemopoiesissq~ZKt0P:cytokine and chemokine mediated signaling p...sq~Z'tP:response to UV-Bsq~Z=tP:peptide transportsq~Z>tP:RNA metabolic processsq~Z?tP:cell-cell adhesionsq~Z@t%P:negative regulation of angiogenesissq~Z@tP:protein ubiquitinationsq~Z@tP:histone methylationsq~ZFt!P:peptidyl-serine phosphorylationsq~Z{t!P:regulation of protein stabilitysq~Z|t0P:regulation of glucocorticoid metabolic processsq~Z=t.P:negative regulation of programmed cell deathsq~Zst0P:positive regulation of I-kappaB kinase/NF-k...sq~Zt0P:proteasomal ubiquitin-dependent protein cat...sq~Zt%P:regulation of lipid kinase activitysq~ZktP:response to estrogen stimulussq~ZmtP:cell fate commitmentsq~ZtP:cellular respirationsq~ZtP:fat cell differentiationsq~Zt/P:calcium-dependent phospholipase A2 activationsq~ZtP:regulation of apoptosissq~Zt0P:DNA damage response, signal transduction by...sq~Z~t0P:positive regulation of proteasomal ubiquiti...sq~Zt,P:positive regulation of histone acetylationsq~Z*tP:protein refoldingsq~Zt)P:cellular response to glucose starvationsq~Zt)P:regulation of protein catabolic processsq~ZWt(P:positive regulation of phosphorylationsq~ZbtP:response to starvationsq~ZtP:cholesterol homeostasissq~ZFt0P:negative regulation of myeloid cell differe...sq~ZGtP:ER overload responsesq~ZtP:mesonephros developmentsq~ZtP:inactivation of MAPK activitysq~ZtP:activation of MAPK activitysq~ZtP:activation of MAPKK activitysq~Zt0P:two-component signal transduction system (p...sq~ZRt'P:G1/S transition of mitotic cell cyclesq~ZPt P:G1 phase of mitotic cell cyclesq~Zt0P:Wnt receptor signaling pathway through beta...sq~ZKtP:cell cycle checkpointsq~Z<t,P:protein import into nucleus, translocationsq~Zt0P:generation of precursor metabolites and energysq~ZttP:DNA replicationsq~ZtP:protein polyubiquitinationsq~ZtP:spliceosome assemblysq~Zt P:M phasesq~ZtP:mesoderm formationsq~Zt P:in utero embryonic developmentsq~ZtP:cell glucose homeostasissq~Z{tP:thermoregulationsq~ZtP:regulation of cell growthsq~Zt$P:prostaglandin biosynthetic processsq~ZtP:ossificationsq~ZtP:skeletal developmentsq~ZtP:cell morphogenesissq~Zt0P:double-strand break repair via homologous r...sq~ZtP:telomere maintenancesq~Zt$P:base-excision repair, DNA ligationsq~ZtP:postreplication repairsq~ZtP:double-strand break repairsq~ZtP:caspase activationsq~Z9t"P:glucocorticoid catabolic processsq~Zt P:endocytosissq~ZBt0P:DNA damage response, signal transduction by...sq~Z8tP:cellular defense responsesq~ZntP:vitamin metabolic processsq~Zt#P:nitric oxide biosynthetic processsq~Z)tP:acute-phase responsesq~Zt P:transportsq~ZtP:mitochondrial transportsq~ZtP:muscle contractionsq~ZtP:cell motilitysq~ZtP:cellular zinc ion homeostasissq~Z&tP:steroid biosynthetic processsq~ZptP:ubiquitin cyclesq~Zt!P:intracellular protein transportsq~ZtP:DNA dealkylationsq~ZtP:DNA recombinationsq~Zt0P:establishment and/or maintenance of chromat...sq~ZtP:nucleosome disassemblysq~Zt0P:regulation of transcription from RNA polyme...sq~ZtP:mRNA processingsq~Z t P:translationsq~Z.t(P:regulation of translational initiationsq~Z9tP:protein foldingsq~Z tP:activated T cell apoptosissq~Z>tF:protein bindingsq~Zt'tF:transcription factor activitysq~Z$t$F:transcription coactivator activitysq~ZtF:androgen receptor bindingsq~Z t$F:transcription corepressor activitysq~Z] t F:DNA bindingsq~Zv t0F:RNA polymerase II transcription factor acti...sq~Z2tF:identical protein bindingsq~Z@t"F:transcription activator activitysq~Zt F:ATP bindingsq~Zv{tF:estrogen receptor bindingsq~ZtF:signal transducer activitysq~Z NtF:zinc ion bindingsq~Z}tF:protein N-terminus bindingsq~ZBt*F:protein serine/threonine kinase activitysq~Zvt"F:thyroid hormone receptor bindingsq~Zt,F:ligand-dependent nuclear receptor activitysq~Zvt0F:ligand-dependent nuclear receptor transcrip...sq~ZVtF:protein C-terminus bindingsq~ZMtF:enzyme bindingsq~Zut'F:protein tyrosine phosphatase activitysq~ZMtF:protein kinase bindingsq~Z@Gt0F:RNA polymerase II transcription mediator ac...sq~Z3t#F:protein homodimerization activitysq~Z-tF:sequence-specific DNA bindingsq~Zt F:RNA bindingsq~Zt%F:protein heterodimerization activitysq~Z2t$F:histone acetyltransferase activitysq~Z't-F:insulin-like growth factor receptor bindingsq~Zzt0F:ligand-regulated transcription factor activitysq~Z?{t0F:general RNA polymerase II transcription fac...sq~Z(t$F:insulin receptor substrate bindingsq~Z@t"F:transcription repressor activitysq~ZjtF:double-stranded DNA bindingsq~Zt!F:transcription cofactor activitysq~ZxtF:TPR domain bindingsq~Zt#F:thyroid hormone receptor activitysq~ZtF:receptor activitysq~ZbtF:chromatin bindingsq~Z"tF:helicase activitysq~Zut.F:receptor signaling complex scaffold activitysq~ZtF:receptor bindingsq~Zit"F:protein-tyrosine kinase activitysq~Zt#F:phosphoinositide 3-kinase bindingsq~Zt!F:glucocorticoid receptor bindingsq~ZMtF:protein phosphatase bindingsq~Zrt/F:protein serine/threonine phosphatase activitysq~Zyt0F:RNA splicing factor activity, transesterifi...sq~Z9tF:vitamin D receptor bindingsq~ZtF:SH3/SH2 adaptor activitysq~ZSt(F:cAMP-dependent protein kinase activitysq~ZwtF:protein binding, bridgingsq~ZtF:GTPase activator activitysq~Zvt*F:nitric-oxide synthase regulator activitysq~ZctF:MAP kinase activitysq~ZtF:SH2 domain bindingsq~ZutF:ErbB-3 class receptor bindingsq~Zt#F:ubiquitin-protein ligase activitysq~ZtF:actin bindingsq~ZutF:retinoid X receptor bindingsq~Zt+F:epidermal growth factor receptor activitysq~Z@t-F:specific transcriptional repressor activitysq~Z{t#F:steroid hormone receptor activitysq~ZtF:transcription factor bindingsq~ZdtF:damaged DNA bindingsq~ZytF:MyoD bindingsq~ZBt+F:ligand-dependent nuclear receptor bindingsq~ZC t0F:negative regulator of basal transcription a...sq~Z&tF:insulin receptor bindingsq~ZdtF:MAP kinase kinase activitysq~ZtF:AF-2 domain bindingsq~Z,t#F:prostaglandin-E synthase activitysq~Zft F:MAP/ERK kinase kinase activitysq~ZqtF:CD4 receptor bindingsq~ZtF:DNA strand annealing activitysq~Z=tF:phosphate bindingsq~ZʧtF:Hsp90 protein bindingsq~ZXt0F:phosphatidylinositol-3,4-bisphosphate 3-pho...sq~Zt0F:inositol-1,3,4,5-tetrakisphosphate 3-phosph...sq~Zlt0F:receptor signaling protein tyrosine kinase ...sq~ZǭtF:ATPase bindingsq~Zet#F:MAP kinase kinase kinase activitysq~ZNJtF:unfolded protein bindingsq~ZstF:NF-kappaB bindingsq~ZGtF:actin filament bindingsq~ZtF:protein dimerization activitysq~Zt0F:histone lysine N-methyltransferase activity...sq~Z\tF:nucleic acid bindingsq~ZTtF:GTPase activitysq~Zt%F:ATP-dependent RNA helicase activitysq~Zt(F:translation initiation factor activitysq~ZtF:RNA helicase activitysq~ZtF:receptor antagonist activitysq~Z|t!F:retinoic acid receptor activitysq~ZVt-F:phosphatidylinositol-3-phosphatase activitysq~ZtF:nuclease activitysq~Zyt0F:RNA polymerase II transcription factor acti...sq~Zxt0F:specific RNA polymerase II transcription fa...sq~ZtF:telomerase activitysq~ZtF:glycoprotein bindingsq~ZtF:SMAD bindingsq~Z/t0F:histone lysine N-methyltransferase activity...sq~ZJtF:protein kinase CK2 activitysq~ZUt*F:cyclin-dependent protein kinase activitysq~ZrtF:CD8 receptor bindingsq~Z'tF:insulin bindingsq~Zt.F:phosphoinositide 3-kinase regulator activitysq~ZtF:calmodulin bindingsq~Z?t*F:1-phosphatidylinositol-3-kinase activitysq~Z?t0F:phosphatidylinositol-3,4,5-trisphosphate 3-...sq~ZtF:calcium ion bindingsq~ZtF:copper ion bindingsq~ZytF:androgen bindingsq~ZxtF:steroid bindingsq~ZNtF:structural molecule activitysq~ZAdtF:transferase activitysq~ZAtF:ATPase activitysq~ZBtF:snRNA bindingsq~Z"t*F:epidermal growth factor receptor bindingsq~ZMKt+F:small conjugating protein ligase activitysq~Zt$F:insulin-like growth factor bindingsq~Z=tF:tubulin bindingsq~Z<}tF:cholesterol bindingsq~ZtF:N-acetyltransferase activitysq~ZtF:growth factor activitysq~Zt0F:translation factor activity, nucleic acid b...sq~ZtF:N-methyltransferase activitysq~Z tF:heparin bindingsq~Z Gt0F:pyrimidine-specific mismatch base pair DNA ...sq~Z mtF:DNA bending activitysq~Z tF:MP kinase activitysq~Z t(F:RNA polymerase subunit kinase activitysq~Z tF:IkappaB kinase activitysq~Z!t'F:protein kinase CK2 regulator activitysq~ZtF:phosphatidylinositol bindingsq~ZtF:phospholipid bindingsq~ZMtF:kinase bindingsq~ZMt!F:protein domain specific bindingsq~Zt%F:receptor signaling protein activitysq~Zvt/F:thyroid hormone receptor coactivator activitysq~Z~tF:DNA hairpin bindingsq~Zt)F:tumor necrosis factor receptor activitysq~Z|t*F:N-terminal myristoylation domain bindingsq~Zw@t"F:transcription regulator activitysq~Z{+t0F:thyrotropin-releasing hormone receptor bindingsq~ZwPtF:Hsp70 protein bindingsq~ZwRtF:receptor activator activitysq~ZtF:androgen receptor activitysq~ZtF:retinoid-X receptor activitysq~Zt0F:aryl hydrocarbon receptor nuclear transloca...sq~Zt0F:transmembrane receptor protein tyrosine kin...sq~Zt0F:Rho guanyl-nucleotide exchange factor activitysq~Zut(F:Hsp70/Hsc70 protein inhibitor activitysq~ZtF:Notch bindingsq~ZtF:Rho GTPase activator activitysq~ZvLtF:estrogen receptor activitysq~Zt0F:cyclin-dependent protein kinase inhibitor a...sq~ZtF:protein complex scaffoldsq~Zt.F:insulin-like growth factor receptor activitysq~Z*t!F:sterol response element bindingsq~ZutF:PDZ domain bindingsq~Z>t C:nucleussq~Zit C:cytoplasmsq~Zt C:nucleoplasmsq~ZtC:plasma membranesq~Zbt C:nucleolussq~Zt C:cytosolsq~ZtC:membrane fractionsq~ZtC:intracellularsq~Z#tC:transcription factor complexsq~ZwtC:mediator complexsq~Zt#C:histone methyltransferase complexsq~Z@t C:PML bodysq~Zt C:chromatinsq~ZtC:integral to plasma membranesq~ZAt C:lipid raftsq~ZktC:mitochondrionsq~Zt(C:NuA4 histone acetyltransferase complexsq~Z1t C:spliceosomesq~ZtC:nuclear chromosomesq~ZWt!C:perinuclear region of cytoplasmsq~Z>tC:integral to membranesq~Zt0C:eukaryotic translation initiation factor 3 ...sq~Z+tC:holo TFIIH complexsq~ZtC:insoluble fractionsq~ZBt#C:transcriptional repressor complexsq~Zt&C:proteasome complex (sensu Eukaryota)sq~Z%t$C:transcription factor TFIID complexsq~Zt-C:phosphoinositide 3-kinase complex, class IAsq~ZtC:condensed chromosomesq~ZtC:endoplasmic reticulumsq~Z@tC:nuclear specksq~Zt C:endoplasmic reticulum membranesq~ZDtC:protein kinase CK2 complexsq~Z@t'C:cAMP-dependent protein kinase complexsq~ZtC:Golgi membranesq~Z}tC:PCAF complexsq~Z{t#C:histone acetyltransferase complexsq~Z%tC:focal adhesionsq~ZtC:cytoskeletonsq~Zt"C:heterotrimeric G-protein complexsq~Z@tC:chromatin remodeling complexsq~Z$tC:polysomal ribosomesq~Zt+C:outer kinetochore of condensed chromosomesq~ZtC:extracellular spacesq~ZztC:BRCA1-BARD1 complexsq~Z>t C:membranesq~Zxt"C:beta-catenin destruction complexsq~Z!t.C:DNA-directed RNA polymerase II, core complexsq~ZtC:nuclear envelopesq~ZtC:synaptonemal complexsq~Z@tC:caveolar membranesq~ZAtC:telomerase holoenzyme complexsq~Zt C:endosomesq~ZtC:pericentriolar materialsq~ZotC:mitochondrial inner membranesq~Z?tC:nuclear matrixsq~Zzt&C:ubiquitin conjugating enzyme complexsq~Z RtC:gamma-tubulin ring complexsq~Z?tC:lateral plasma membranesq~Z tC:chromosome, telomeric regionsq~ZtC:ruffleppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~t%P:estrogen receptor signaling pathwayt30520sq~t,P:regulation of transcription, DNA-dependentt6355sq~tF:estrogen receptor activityt30284sq~t*F:nitric-oxide synthase regulator activityt30235sq~tF:protein N-terminus bindingt47485sq~tC:chromatin remodeling complext16585sq~t C:membranet16020pppxsq~uq~ sq~t IPR000536tNucl_hrmn_rcpt_lig-bd_coresq~t IPR008946tNucl_hrmn_rcpt_lig_bdsq~t IPR001292tOestr_rcpt_AF1sq~t IPR012239tOestrogen_rcptsq~t IPR001723t Str_hrmn_rcptsq~t IPR001628t Znf_hrmn_rcptppppxsq~uq~ sq~t Hormone_receptPF00104sq~t Oest_receptPF02159sq~tzf-C4tPF00105pppppppxtP03372t ESR1_HUMANsq~uq~ sq~tERsq~tEstradiol receptorsq~tER-alphasq~t-Nuclear receptor subfamily 3 group A member 1ppppppxt Homo sapienstSOMAsq~P?{NRLSM%tSomatotropin precursorsq~uq~ sq~UStENSG00000189162pppppppppxsq~uq~ sq~mStGH1pppppppppxsq~uq~ @sq~ZStP:signal transductionsq~Z St P:translationsq~ZJSt.P:regulation of progression through cell cyclesq~Z ]St+P:negative regulation of cell proliferationsq~ZStP:anti-apoptosissq~ZsSt0P:positive regulation of I-kappaB kinase/NF-k...sq~Z StP:translational initiationsq~Z!`StP:epidermis developmentsq~ZStP:skeletal developmentsq~ZStP:nucleocytoplasmic transportsq~Z [StP:cell proliferationsq~ZtStP:DNA replicationsq~ZStP:nucleosome assemblysq~Z&StP:response to stresssq~ZStP:cell motilitysq~ZSt P:cell agingsq~ZStP:induction of apoptosissq~Z.St(P:regulation of translational initiationsq~Z*StP:inflammatory responsesq~ZJStP:response to unfolded proteinsq~ZStP:embryo implantationsq~ZStP:cell cycle arrestsq~ZSt0P:G-protein coupled receptor protein signalin...sq~ZStP:centrosome cyclesq~ZSt0P:transmembrane receptor protein tyrosine kin...sq~ZSt!P:intercellular junction assemblysq~ZSt!P:intracellular protein transportsq~ZSt P:glycolysissq~ZSt$P:DNA fragmentation during apoptosissq~ZStP:nucleosome disassemblysq~ZSt,P:regulation of transcription, DNA-dependentsq~ZSt0P:RNA elongation from RNA polymerase II promotersq~ZStP:mRNA processingsq~ZStP:visual perceptionsq~ZStP:fatty acid beta-oxidationsq~ZStP:translational elongationsq~Z9StP:protein foldingsq~Z@StP:protein modification processsq~ZFSt&P:protein amino acid dephosphorylationsq~ZoSt/P:ubiquitin-dependent protein catabolic processsq~ZStP:lipid metabolic processsq~Z&StP:steroid biosynthetic processsq~ZStP:tricarboxylic acid cyclesq~ZSt P:lactationsq~ZSt,P:negative regulation of histone acetylationsq~ZGStP:growthsq~Z~StP:T cell activationsq~ZStP:ribosome assemblysq~ZSt*P:tyrosine phosphorylation of JAK2 proteinsq~ZSt)P:negative regulation of caspase activitysq~ZStP:proteasome assemblysq~Z5St$P:intermediate filament organizationsq~ZSt$P:prostaglandin biosynthetic processsq~ZStP:cellular respirationsq~ZFStP:actin filament severingsq~ZStP:telomere maintenancesq~ZISt!P:actin filament bundle formationsq~ZSt(P:nuclear mRNA splicing, via spliceosomesq~ZǔSt.P:activation of NF-kappaB transcription factorsq~ZHSt&P:positive regulation of cell motilitysq~ZySt0P:negative regulation of microtubule polymeri...sq~Zv StP:erythrocyte differentiationsq~ZDSt$P:protein amino acid phosphorylationsq~Z=5StP:gas transportsq~Z'St$P:response to extracellular stimulussq~Z#St.P:ribonucleoside diphosphate catabolic processsq~Z!St%P:caspase activation via cytochrome csq~Z!St0P:induction of apoptosis by intracellular sig...sq~ZSt.P:actin polymerization and/or depolymerizationsq~ZSt&P:establishment of blood-nerve barriersq~ZaStP:tRNA processingsq~Z>St P:Wnt receptor signaling pathwaysq~Z>StP:mRNA metabolic processsq~ZvStP:keratinocyte differentiationsq~ZKSt"P:leukotriene biosynthetic processsq~ZRSt'P:G1/S transition of mitotic cell cyclesq~ZKgStP:D-ribose catabolic processsq~ZFStP:peptide cross-linkingsq~Z?St&P:calcium-dependent cell-cell adhesionsq~Z)StF:protein bindingsq~ZSt F:RNA bindingsq~Z2StF:identical protein bindingsq~ZSt$F:structural constituent of ribosomesq~Z3St#F:protein homodimerization activitysq~ZSt$F:transcription corepressor activitysq~ZSt$F:transcription coactivator activitysq~ZSt0F:translation factor activity, nucleic acid b...sq~Z )StF:peptidase activitysq~ZTStF:GTPase activitysq~ZStF:calcium ion bindingsq~ZNJStF:unfolded protein bindingsq~ZStF:signal transducer activitysq~ZSt,F:adenine phosphoribosyltransferase activitysq~ZJStF:dUTP diphosphatase activitysq~ZSt%F:ATP-dependent RNA helicase activitysq~ZStF:adenylate kinase activitysq~ZJSt"F:ADP-sugar diphosphatase activitysq~ZKStF:nucleoside kinase activitysq~Z?PSt F:AMP bindingsq~Z!St0F:protein phosphatase type 2A regulator activitysq~Z!St'F:protein kinase CK2 regulator activitysq~Z}St0F:methenyltetrahydrofolate cyclohydrolase act...sq~Z St0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~Z St"F:glutathione transferase activitysq~ZSt*F:formate-tetrahydrofolate ligase activitysq~Z=StF:toxin bindingsq~ZStF:epoxide hydrolase activitysq~ZStF:enoyl-CoA hydratase activitysq~ZQStF:aminopeptidase activitysq~ZNEStF:heme bindingsq~ZSt)F:acetyl-CoA C-acetyltransferase activitysq~ZStF:actin bindingsq~ZStF:ATPase activator activitysq~ZcSt0F:electron transporter, transferring electron...sq~ZSt%F:protein heterodimerization activitysq~Z,St#F:prostaglandin-E synthase activitysq~ZBStF:microtubule plus-end bindingsq~ZsStF:NF-kappaB bindingsq~ZuStF:ADP reductase activitysq~ZǏStF:chaperone bindingsq~Z]St F:DNA bindingsq~ZqStF:single-stranded DNA bindingsq~ZSt,F:ornithine decarboxylase activator activitysq~ZwStF:protein binding, bridgingsq~ZxStF:Tat protein bindingsq~Zy`StF:heat shock protein bindingsq~ZSt(F:translation elongation factor activitysq~Z|St*F:N-terminal myristoylation domain bindingsq~ZSt(F:translation initiation factor activitysq~ZStF:telomerase activitysq~ZStF:histone bindingsq~ZStF:nucleotide bindingsq~ZPSt(F:structural constituent of cytoskeletonsq~ZSt(F:protein phosphatase inhibitor activitysq~Z'St"F:growth hormone receptor activitysq~Z=StF:prolactin receptor activitysq~ZSt%F:GDP-dissociation inhibitor activitysq~ZSt)F:Rab GDP-dissociation inhibitor activitysq~ZNStF:structural molecule activitysq~ZpSt F:bindingsq~ZStF:fatty acid bindingsq~ZSt F:ATP bindingsq~ZWSt F:NAD bindingsq~ZSt"F:phospholipase inhibitor activitysq~ZVStF:protein C-terminus bindingsq~Z NStF:zinc ion bindingsq~ZJStF:protein kinase CK2 activitysq~Z!XStF:Ran GTPase bindingsq~ZcStF:MAP kinase activitysq~Z!ZStF:proteasome activator activitysq~ZSt#F:ubiquitin-protein ligase activitysq~ZSt0F:pyruvate dehydrogenase (acetyl-transferring...sq~ZStF:transketolase activitysq~ZStF:serine-tRNA ligase activitysq~ZSt0F:methylenetetrahydrofolate dehydrogenase act...sq~ZSt C:nucleussq~Zi St C:cytoplasmsq~ZSt&C:proteasome complex (sensu Eukaryota)sq~ZkStC:mitochondrionsq~ZSt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZbSt C:nucleolussq~ZStC:integral to plasma membranesq~ZSt C:cytosolsq~ZWSt!C:perinuclear region of cytoplasmsq~ZSt0C:eukaryotic translation elongation factor 1 ...sq~ZSt0C:proteasome regulatory particle (sensu Eukar...sq~ZStC:plasma membranesq~ZSt%C:protein phosphatase type 2A complexsq~Z'StC:cell surfacesq~Z= StC:actin cytoskeletonsq~ZSt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZSt C:nucleosomesq~ZSt0C:eukaryotic translation initiation factor 3 ...sq~Z StC:chromosome, telomeric regionsq~ZSt C:microtubulesq~ZStC:cytoskeletonsq~ZStC:cornified envelopesq~ZDStC:protein kinase CK2 complexsq~ZySt#C:cortical microtubule cytoskeletonsq~Z bSt!C:F-actin capping protein complexsq~ZStC:intracellularsq~Z1St C:spliceosomesq~ZAStC:telomerase holoenzyme complexsq~ZStC:soluble fractionsq~ZStC:membrane fractionsq~Z~St#C:mitochondrial intermembrane spacesq~ZStC:endoplasmic reticulumsq~ZSt C:centrosomesq~ZStC:protein complexsq~ZuiSt C:desmosomeppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq~uq~ sq~StP:glucose transportt15758sq~StP:signal transductiont7165sq~St!F:growth hormone receptor bindingt5131sq~StF:hormone activityt5179ppppppxsq~uq~ sq~St IPR012351t4_helix_cytokine_coresq~St IPR001400t Somatotropinppppppppxsq~uq~ sq~St Hormone_1tPF00103pppppppppxtP01241t SOMA_HUMANsq~uq~ sq~StGrowth hormonesq~StGHsq~StGH-Nsq~StPituitary growth hormonesq~StGrowth hormone 1pppppxt Homo sapienstEIF1Bsq~P?jP%t+Eukaryotic translation initiation factor 1bsq~uq~ sq~UPtENSG00000114784pppppppppxsq~uq~ sq~mPtEIF1Bpppppppppxsq~uq~ @sq~Z Pt P:translationsq~Z.Pt(P:regulation of translational initiationsq~ZJPt.P:regulation of progression through cell cyclesq~Z [PtP:cell proliferationsq~ZoPt/P:ubiquitin-dependent protein catabolic processsq~ZPtP:signal transductionsq~ZPtP:cell motilitysq~Z ]Pt+P:negative regulation of cell proliferationsq~Z=PtP:protein complex assemblysq~Z PtP:translational initiationsq~ZtPtP:DNA replicationsq~ZPt0P:regulation of transcription from RNA polyme...sq~ZPtP:induction of apoptosissq~ZPt!P:intracellular protein transportsq~ZPtP:lipid metabolic processsq~ZOPt P:protein amino acid methylationsq~Z@PtP:protein modification processsq~ZPt%P:phosphoinositide-mediated signalingsq~ZPt0P:cell surface receptor linked signal transdu...sq~ZPt P:glycolysissq~ZnPt%P:chaperonin-mediated tubulin foldingsq~ZOPt0P:regulation of cyclin-dependent protein kina...sq~ZPtP:nucleosome assemblysq~ZPtP:protein polyubiquitinationsq~ZJPt'P:one-carbon compound metabolic processsq~ZPt0P:retrograde vesicle-mediated transport, Golg...sq~ZPt"P:cellular calcium ion homeostasissq~ZPtP:ceramide metabolic processsq~ZPtP:fatty acid beta-oxidationsq~ZPt0P:establishment and/or maintenance of cell po...sq~ZPt"P:regulation of muscle contractionsq~ZPt P:apoptosissq~ZCPtP:response to oxidative stresssq~ZPt P:endocytosissq~ZPt(P:intra-Golgi vesicle-mediated transportsq~ZPtP:cell cycle arrestsq~ZPtP:regulation of mitosissq~ZPt(P:ER to Golgi vesicle-mediated transportsq~ZPtP:nucleocytoplasmic transportsq~ZPt/P:cotranslational protein targeting to membranesq~ZPtP:transcriptionsq~ZPtP:chromatin remodelingsq~ZPtP:nucleosome disassemblysq~ZPt,P:regulation of transcription, DNA-dependentsq~ZPtP:DNA recombinationsq~ZPt$P:base-excision repair, DNA ligationsq~ZPtP:base-excision repairsq~ZPtP:regulation of DNA repairsq~ZPt P:DNA repairsq~ZPtP:regulation of DNA replicationsq~ZPtP:regulation of transcriptionsq~ZPt/P:transcription from RNA polymerase II promotersq~ZPtP:protein export from nucleussq~ZPtP:protein targetingsq~ZnPtP:ATP-dependent proteolysissq~ZJPt+P:N-terminal protein amino acid acetylationsq~ZFPt&P:protein amino acid dephosphorylationsq~ZaPt!P:Ras protein signal transductionsq~Z9PtP:protein foldingsq~Z%PtP:tyrosyl-tRNA aminoacylationsq~ZPtP:translational elongationsq~ZPtP:mRNA processingsq~Z|Pt"P:DNA unwinding during replicationsq~ZHPt&P:positive regulation of cell motilitysq~ZPt%P:regulation of macrophage activationsq~ZPtP:regulation of apoptosissq~ZPt0P:negative regulation of tyrosine phosphoryla...sq~ZPt,P:negative regulation of histone acetylationsq~ZzPt/P:positive regulation of protein ubiquitinationsq~ZyPt0P:negative regulation of microtubule polymeri...sq~ZwPtP:maturation of SSU-rRNAsq~ZvdPt$P:negative regulation of cell growthsq~Zv PtP:erythrocyte differentiationsq~ZuPtP:regulation of cell adhesionsq~ZuPt.P:regulation of Wnt receptor signaling pathwaysq~Z9Pt"P:positive regulation of apoptosissq~Z:Pt"P:negative regulation of apoptosissq~ZsPt0P:positive regulation of I-kappaB kinase/NF-k...sq~ZǝPtP:regulation of DNA bindingsq~ZIPt!P:actin filament bundle formationsq~ZFPtP:actin filament severingsq~ZPt P:hypoxanthine metabolic processsq~ZPt0P:positive regulation of dopamine metabolic p...sq~ZEPt0P:positive regulation of transcription, DNA-d...sq~ZDPt0P:negative regulation of transcription, DNA-d...sq~ZPt$P:regulation of cell differentiationsq~ZPtP:cell redox homeostasissq~ZPtP:actin nucleationsq~ZPt0P:positive regulation of DNA damage response,...sq~ZuPtP:protein repairsq~ZuaPtP:muscle filament slidingsq~ZPtP:visual perceptionsq~ZPtP:blood coagulationsq~ZPtP:embryo implantationsq~Z_PtP:striated muscle developmentsq~Z]PtP:muscle developmentsq~ZPtP:axonogenesissq~ZsPtP:spermatogenesissq~ZkPt&P:multicellular organismal developmentsq~Z`Pt+P:small GTPase mediated signal transductionsq~ZUPt'P:cytoplasmic sequestering of NF-kappaBsq~Z%PtP:protein kinase C activationsq~ZPt P:behaviorsq~ZPt.P:actin polymerization and/or depolymerizationsq~Z PtP:asymmetric cell divisionsq~ZMPt%P:second-messenger-mediated signalingsq~Z?@PtP:vesicle-mediated transportsq~Z>PtP:mRNA metabolic processsq~Z=5PtP:gas transportsq~Z'1PtP:response to organic substancesq~Z'Pt$P:response to extracellular stimulussq~Z$Pt0P:pyrimidine ribonucleotide biosynthetic processsq~Z#PtP:nucleotide metabolic processsq~Z#Pt"P:purine base biosynthetic processsq~Z!`PtP:epidermis developmentsq~Z PtP:RNA splicingsq~ZPt0P:G-protein coupled receptor protein signalin...sq~ZEPt)P:pyrimidine nucleoside metabolic processsq~ZPtP:purine ribonucleoside salvagesq~ZYPtP:protein homotetramerizationsq~ZPt$P:prostaglandin biosynthetic processsq~ZPtP:skeletal developmentsq~ZPt$P:DNA double-strand break processingsq~ZPtP:inactivation of MAPK activitysq~ZKPtP:cell cycle checkpointsq~ZPt0P:ribosomal small subunit assembly and mainte...sq~ZWPt P:carbohydrate metabolic processsq~ZPt(P:purine nucleotide biosynthetic processsq~ZVPtF:protein bindingsq~ZPt F:RNA bindingsq~ZPt$F:structural constituent of ribosomesq~ZPt(F:translation initiation factor activitysq~ZPt0F:translation factor activity, nucleic acid b...sq~Z2PtF:identical protein bindingsq~ZPtF:calcium ion bindingsq~ZqPtF:single-stranded DNA bindingsq~ZTPtF:GTPase activitysq~ZNJPtF:unfolded protein bindingsq~Z]Pt F:DNA bindingsq~Z!Pt0F:protein phosphatase type 2A regulator activitysq~Z PtF:3'-5' exonuclease activitysq~Z#_PtF:electron carrier activitysq~Z_PtF:transporter activitysq~ZPt F:GTP bindingsq~ZPtF:signal transducer activitysq~Z NPtF:zinc ion bindingsq~Z Pt0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq~ZWPt F:NAD bindingsq~Z@Pt"F:transcription activator activitysq~Z@kPtF:oxidoreductase activitysq~ZPt)F:acetyl-CoA C-acetyltransferase activitysq~ZPt!F:adenosylhomocysteinase activitysq~Z:Pt+F:protein disulfide oxidoreductase activitysq~Z mPtF:DNA bending activitysq~ZPtF:adenylate kinase activitysq~ZPt%F:carbonyl reductase (NADPH) activitysq~Z}Pt"F:ubiquitin thiolesterase activitysq~Z sPt"F:structural constituent of musclesq~Z!XPtF:Ran GTPase bindingsq~Z!Pt'F:protein kinase CK2 regulator activitysq~Z PtF:selenium bindingsq~ZPtF:enoyl-CoA hydratase activitysq~Z xPtF:7S RNA bindingsq~ZOPtF:endopeptidase activitysq~ZGPtF:dopachrome isomerase activitysq~ZPtF:creatine kinase activitysq~ZAPtF:ATPase activitysq~ZKPtF:nucleoside kinase activitysq~ZMPtF:enzyme bindingsq~ZPt$F:transcription coactivator activitysq~ZtPtF:transcription factor activitysq~ZjPtF:double-stranded DNA bindingsq~Z^PtF:DNA helicase activitysq~Z-PtF:sequence-specific DNA bindingsq~ZPt#F:selenide, water dikinase activitysq~ZPtF:magnesium ion bindingsq~ZPtF:metal ion bindingsq~ZPt%F:protein heterodimerization activitysq~ZBPtF:microtubule plus-end bindingsq~Z3Pt#F:protein homodimerization activitysq~ZPt$F:transcription corepressor activitysq~ZPtF:histone bindingsq~ZBPt0F:DNA-(apurinic or apyrimidinic site) lyase a...sq~Z;Pt&F:DNA-directed RNA polymerase activitysq~ZPtF:antigen bindingsq~ZPtF:actin bindingsq~ZuPt.F:receptor signaling complex scaffold activitysq~ZPtF:motor activitysq~ZPt(F:translation elongation factor activitysq~ZxPt!F:actin-dependent ATPase activitysq~ZPtF:mRNA bindingsq~Z|Pt*F:N-terminal myristoylation domain bindingsq~ZǏPtF:chaperone bindingsq~ZFPt0F:hypoxanthine phosphoribosyltransferase acti...sq~Z~PtF:MutLalpha complex bindingsq~ZPt#F:uracil DNA N-glycosylase activitysq~ZPtF:uridine kinase activitysq~ZPt0F:cyclin-dependent protein kinase inhibitor a...sq~ZPt(F:protein phosphatase inhibitor activitysq~ZPt%F:GDP-dissociation inhibitor activitysq~ZPt)F:Rab GDP-dissociation inhibitor activitysq~ZPtF:cytokine activitysq~Z!Pt F:interleukin-8 receptor bindingsq~ZNPtF:structural molecule activitysq~ZPPt(F:structural constituent of cytoskeletonsq~ZPtF:acid phosphatase activitysq~ZxPtF:steroid bindingsq~ZPtF:fatty acid bindingsq~ZPt F:ATP bindingsq~ZPt#F:ubiquitin-protein ligase activitysq~ZPt0F:phosphoribosylaminoimidazolesuccinocarboxam...sq~ZPtF:ribonuclease H activitysq~ZoPt0F:protein-L-isoaspartate (D-aspartate) O-meth...sq~ZPt F:endodeoxyribonuclease activitysq~ZJPtF:protein kinase CK2 activitysq~Z PtF:heparin bindingsq~ZPt*F:ornithine-oxo-acid transaminase activitysq~ZPtF:phosphodiesterase I activitysq~ZPtF:N-methyltransferase activitysq~ZVPtF:protein C-terminus bindingsq~ZPt"F:phospholipase inhibitor activitysq~ZPtF:transaldolase activitysq~ZPtF:tyrosine-tRNA ligase activitysq~ZPtF:transketolase activitysq~ZiPt C:cytoplasmsq~ZPt C:nucleussq~Z Pt0C:cytosolic small ribosomal subunit (sensu Eu...sq~ZPt0C:cytosolic large ribosomal subunit (sensu Eu...sq~ZPt&C:proteasome complex (sensu Eukaryota)sq~ZPt0C:eukaryotic translation initiation factor 3 ...sq~ZkPtC:mitochondrionsq~ZbPt C:nucleolussq~ZPtC:soluble fractionsq~ZPtC:endoplasmic reticulumsq~ZWPt!C:perinuclear region of cytoplasmsq~ZPt C:cytosolsq~Z>Pt C:membranesq~ZPtC:plasma membranesq~ZPtC:Arp2/3 protein complexsq~ZPtC:extracellular regionsq~Z= PtC:actin cytoskeletonsq~ZPt C:ribosomesq~Z'PtC:cell surfacesq~ZyPt0C:mitochondrial proton-transporting ATP synth...sq~ZPtC:intracellularsq~ZPt0C:eukaryotic translation elongation factor 1 ...sq~ZPtC:mitochondrial matrixsq~ZPt"C:DNA replication factor A complexsq~ZPtC:condensed chromosomesq~ZPt"C:muscle thin filament tropomyosinsq~ZPtC:nuclear chromosomesq~ZPtC:late endosomesq~ZPtC:endoplasmic reticulum lumensq~ZDPtC:protein kinase CK2 complexsq~Z#PtC:tight junctionsq~ZPt+C:proteasome core complex (sensu Eukaryota)sq~ZPt0C:proteasome regulatory particle (sensu Eukar...sq~ZPtC:ubiquitin ligase complexsq~ZPt%C:protein phosphatase type 2A complexsq~ZPtC:synaptonemal complexsq~ZPtC:integral to plasma membranesq~ZPt C:centrosomesq~Z=PtC:microtubule cytoskeletonsq~ZPtC:translocon complexsq~Z?Pt0C:eukaryotic translation initiation factor 4F...sq~Z@MPtC:unconventional myosin complexsq~Z|PtC:nuclear membranesq~ZzPtC:UBC13-MMS2 complexsq~ZyPt#C:cortical microtubule cytoskeletonsq~ZPt C:nucleoplasmsq~Z@Pt C:PML bodysq~ZPt C:polysomesq~ZPt C:microtubulesq~ZPt(C:NuA4 histone acetyltransferase complexsq~Z bPt!C:F-actin capping protein complexsq~ZPt C:lysosomesq~ZPtC:extracellular spacesq~ZPt0C:signal recognition particle, endoplasmic re...sq~Z>PtC:integral to membranesq~ZPt"C:DNA replication factor C complexsq~Z?PtC:prefoldin complexsq~ZPtC:paraspecklessq~ZuPtC:COPI vesicle coatpppppppppppppppppppppppppppppppppppppxsq~uq~ sq~Pt(P:regulation of translational initiationt6446sq~PtF:protein bindingt5515ppppppppxsq~uq~ sq~Pt IPR005874tSUI1_euksq~Pt IPR001950tTIF_SUI1ppppppppxsq~uq~ sq~PtSUI1tPF01253pppppppppxtO60739t EIF1B_HUMANsq~uq~ sq~PteIF1bsq~Pt,Protein translation factor SUI1 homolog GC20ppppppppxt Homo sapienstNEP1sq~P %t)Probable ribosome biogenesis protein NEP1sq~uq~ sq~UtENSG00000126749pppppppppxsq~uq~ sq~mtEMG1sq~mtC2Fppppppppxsq~uq~ (sq~ZVt'P:G2/M transition of mitotic cell cyclesq~Zot/P:ubiquitin-dependent protein catabolic processsq~ZtP:cell cycle arrestsq~ZtP:signal transductionsq~Zt0P:cell surface receptor linked signal transdu...sq~Zt P:digestionsq~ZtP:metabolic processsq~Z [tP:cell proliferationsq~Z@at&P:negative regulation of transcriptionsq~ZMt0P:antigen processing and presentation of exog...sq~ZtP:mRNA processingsq~Zt'P:regulation of RNA export from nucleussq~Z]t F:DNA bindingsq~Z@t"F:transcription repressor activitysq~Z!ZtF:proteasome activator activitysq~Zt F:RNA bindingsq~ZatF:cathepsin E activitysq~ZtF:N-acetyltransferase activitysq~Zt"F:threonine endopeptidase activitysq~ZtF:SH3/SH2 adaptor activitysq~ZtF:protein bindingsq~Zt C:nucleussq~Zt&C:proteasome complex (sensu Eukaryota)sq~Zit C:cytoplasmsq~Zt+C:proteasome core complex (sensu Eukaryota)sq~Zt C:endosomesq~Z>t C:membranesq~Z!YtC:proteasome activator complexsq~Zt C:cytosolpppppppppppxsq~uq~ sq~tF:protein bindingt5515sq~tF:snoRNA bindingt30515sq~t+C:small nucleolar ribonucleoprotein complext5732pppppppxsq~uq~ sq~t IPR005304tMra1pppppppppxsq~uq~ sq~tNep1tPF03587pppppppppxtQ92979t NEP1_HUMANsq~uq~ sq~tNucleolar protein EMG1 homologsq~t Protein C2fppppppppxt Homo sapienstCSK21sq~P?*Yd%tCasein kinase II subunit alphasq~uq~ sq~UdtENSG00000101266pppppppppxsq~uq~ sq~mdtCSNK2A1sq~mdtCK2A1ppppppppxsq~uq~ sq~ZdtP:signal transductionsq~Z dt,P:regulation of transcription, DNA-dependentsq~ZJ dt.P:regulation of progression through cell cyclesq~Z dt0P:regulation of transcription from RNA polyme...sq~Z dtP:anti-apoptosissq~Z [ dtP:cell proliferationsq~ZdtP:nervous system developmentsq~Zdt P:transportsq~Z=dtP:protein complex assemblysq~Zkdt&P:multicellular organismal developmentsq~Z+dtP:immune responsesq~ZOdt0P:regulation of cyclin-dependent protein kina...sq~ZSdtP:heart developmentsq~ZdtP:cell cycle arrestsq~ZdtP:response to hypoxiasq~Zdt/P:transcription from RNA polymerase II promotersq~ZDdt$P:protein amino acid phosphorylationsq~Z \dt+P:positive regulation of cell proliferationsq~Z ]dt+P:negative regulation of cell proliferationsq~Zdt P:DNA repairsq~ZEdt0P:positive regulation of transcription, DNA-d...sq~Zdt P:mitosissq~Z9dt"P:positive regulation of apoptosissq~ZdtP:cell adhesionsq~Zdt0P:DNA damage response, signal transduction by...sq~ZdtP:chromosome segregationsq~ZFdt&P:protein amino acid dephosphorylationsq~Z%dt$P:anatomical structure morphogenesissq~Z*dtP:inflammatory responsesq~Z@adt&P:negative regulation of transcriptionsq~Z@dtP:chromatin modificationsq~Z{dt!P:regulation of protein stabilitysq~Z?dtP:phosphorylationsq~ZdtP:blood coagulationsq~Zvddt$P:negative regulation of cell growthsq~Zdt$P:central nervous system developmentsq~ZddtP:synaptic transmissionsq~Z dtP:RNA splicingsq~Z!dtP:apoptotic programsq~Zsdt0P:positive regulation of I-kappaB kinase/NF-k...sq~Zw9dt%P:androgen receptor signaling pathwaysq~Z@dt%P:negative regulation of angiogenesissq~ZUdt'P:cytoplasmic sequestering of NF-kappaBsq~ZtdtP:DNA replicationsq~ZzdtP:DNA ligationsq~Zdt0P:Wnt receptor signaling pathway through beta...sq~Z!dt0P:DNA damage response, signal transduction re...sq~ZdtP:base-excision repairsq~Z`dt+P:small GTPase mediated signal transductionsq~Z`dtP:homeostatic processsq~Zdt0P:establishment and/or maintenance of chromat...sq~ZɗdtP:defense response to virussq~ZJdtP:response to unfolded proteinsq~Z9dtP:protein foldingsq~Zdt%P:phosphoinositide-mediated signalingsq~Z,dt+P:release of cytochrome c from mitochondriasq~ZEdt0P:negative regulation of protein kinase activitysq~Z>dt!P:response to DNA damage stimulussq~ZdtP:lipid metabolic processsq~Zdt(P:nuclear mRNA splicing, via spliceosomesq~Z8dtP:cellular defense responsesq~Zzdt0P:negative regulation of transcription from R...sq~Zudt&P:positive regulation of transcriptionsq~Zdt0P:transcription initiation from RNA polymeras...sq~ZdtP:nucleosome assemblysq~ZdtP:nucleosome disassemblysq~ZdtP:protein localizationsq~ZdtP:visual perceptionsq~ZdtP:sensory perceptionsq~Zdt P:hemostasissq~Z/dtP:humoral immune responsesq~ZdtP:meiotic recombinationsq~ZdtP:regulation of mitosissq~Zdt P:excretionsq~ZdtP:homophilic cell adhesionsq~ZDdtP:redox signal responsesq~Z|dtP:sex differentiationsq~ZdtP:metabolic processsq~Zdt.P:actin polymerization and/or depolymerizationsq~Z!dt0P:induction of apoptosis via death domain rec...sq~ZdtP:cell motilitysq~Z!`dtP:epidermis developmentsq~Z!_dt0P:fibroblast growth factor receptor signaling...sq~Zdt P:chemotaxissq~Z dt P:endosome to lysosome transportsq~Z ^dt$P:insulin receptor signaling pathwaysq~ZedtP:cell recognitionsq~ZdtP:striated muscle contractionsq~Z(dtP:defense responsesq~Z dtP:cholesterol metabolic processsq~ZdtP:response to nutrientsq~Zdt P:cell agingsq~Zadt!P:Ras protein signal transductionsq~ZHdtP:ER-nuclear signaling pathwaysq~Zrdt0P:negative regulation of microtubule depolyme...sq~ZVdt P:JNK cascadesq~ZYdt0P:chromosome organization and biogenesis (sen...sq~ZJdt!P:intracellular signaling cascadesq~Z4dtP:Notch receptor processingsq~Z.dt+P:gamma-aminobutyric acid signaling pathwaysq~Zbdt*P:cytoskeleton organization and biogenesissq~ZkdtP:microtubule depolymerizationsq~Z%dtP:protein kinase C activationsq~ZcdtP:cell-cell signalingsq~Zdt0P:transmembrane receptor protein tyrosine kin...sq~ZGdtP:ER overload responsesq~ZAdt0P:DNA damage response, signal transduction by...sq~Z_dtP:striated muscle developmentsq~Z]dtP:muscle developmentsq~ZBdt0P:DNA damage response, signal transduction by...sq~ZCdtP:response to oxidative stresssq~ZdtP:cell-matrix adhesionsq~Zdt-P:mitotic spindle organization and biogenesissq~ZvdtP:spermatid developmentsq~ZsdtP:spermatogenesissq~Zdt%P:spindle organization and biogenesissq~ZldtP:gamete generationsq~Zdt0P:G-protein coupled receptor protein signalin...sq~Z!dt0P:induction of apoptosis by intracellular sig...sq~ZdtP:cholesterol homeostasissq~Zdt0P:negative regulation of fatty acid biosynthe...sq~Zdt0P:negative regulation of cyclin-dependent pro...sq~Zdt#P:positive regulation of DNA repairsq~Zdt0P:positive regulation of global transcription...sq~Z$dt0P:positive regulation of protein kinase activitysq~Z.dt0P:positive regulation of retroviral genome re...sq~ZDdt0P:negative regulation of transcription, DNA-d...sq~Zxdt0P:positive regulation of transcription from R...sq~Z|dt0P:positive regulation of translational initia...sq~Z_dt0P:positive regulation of myoblast differentia...sq~Zudt0P:positive regulation of nitric oxide biosynt...sq~Zdt#P:protein import into mitochondrionsq~Z%dt0P:mRNA transcription from RNA polymerase II p...sq~Zdt-P:amyloid precursor protein catabolic processsq~ZMdt(P:positive regulation of enzyme activitysq~Zdt)P:negative regulation of caspase activitysq~Zdt0P:proteasomal ubiquitin-dependent protein cat...sq~Zdt$P:negative regulation of DNA bindingsq~Zdt&P:response to peptide hormone stimulussq~ZkdtP:response to estrogen stimulussq~Zdt0P:regulation of phosphoprotein phosphatase ac...sq~Zdt.P:negative regulation of centriole replicationsq~Zdt&P:inositol phosphate dephosphorylationsq~ZdtP:sequestering of calcium ionsq~Z dt0P:release of sequestered calcium ion into cyt...sq~Z>dtP:protein tetramerizationsq~ZdtP:neuron apoptosissq~ZɀdtP:regulation of dopamine uptakesq~ZdtP:cellular response to stimulussq~ZdtP:regulation of cell cyclesq~Zʷdt0P:negative regulation of focal adhesion forma...sq~Zʺdt0P:negative regulation of protein kinase B sig...sq~ZǝdtP:regulation of DNA bindingsq~ZǙdt*P:negative regulation of helicase activitysq~Zǔdt.P:activation of NF-kappaB transcription factorsq~Zdt$P:phosphoinositide dephosphorylationsq~Z6dt0P:regulation of mitochondrial membrane permea...sq~Zdt0P:insulin-like growth factor receptor signali...sq~ZdtP:RNA transportsq~ZQdt%P:positive regulation of neurogenesissq~Zldt!P:regulation of insulin secretionsq~ZƤdt#P:T cell receptor signaling pathwaysq~Zƥdt#P:B cell receptor signaling pathwaysq~ZƩdt0P:positive regulation of antigen receptor-med...sq~Zdt0P:regulation of attachment of spindle microtu...sq~Z8dt P:myelinationsq~Z!dt,P:induction of apoptosis by oxidative stresssq~Z0dtP:programmed cell deathsq~Z6dtP:astrocyte developmentsq~Z6dtP:oligodendrocyte developmentsq~Z:dtP:protein transportsq~Z=dtP:monoamine transportsq~Z@edtP:protein processingsq~Z@dtP:histone acetylationsq~ZFdt(P:N-terminal peptidyl-lysine acetylationsq~ZKdt0P:cytokine and chemokine mediated signaling p...sq~Z'dtP:response to UV-Bsq~Z'1dtP:response to organic substancesq~Z&dt,P:negative regulation of signal transductionsq~Z!dt%P:caspase activation via cytochrome csq~Z$WdtP:rRNA transcriptionsq~Z$XdtP:tRNA transcriptionsq~Z$dtP:response to heatsq~Z%dtP:response to woundingsq~Z%dtP:response to virussq~Z%dtP:response to hormone stimulussq~Z&dtP:response to glucose stimulussq~Z&dtP:organ morphogenesissq~ZWdt(P:protein maturation via protein foldingsq~Zudt.P:regulation of Wnt receptor signaling pathwaysq~Zdt0P:positive regulation of protein amino acid d...sq~Zdt0P:negative regulation of protein amino acid d...sq~Z*dtP:protein refoldingsq~ZtdtP:B cell proliferationsq~Zvdt-P:positive regulation of T cell proliferationsq~Zdt"P:regulation of cell proliferationsq~Zdt)P:cellular response to glucose starvationsq~Zdt)P:regulation of protein catabolic processsq~ZdtP:response to drugsq~Zdt,P:negative regulation of histone acetylationsq~Zzdt/P:positive regulation of protein ubiquitinationsq~Zzfdt0P:positive regulation of protein complex asse...sq~Zv dtP:T cell differentiationsq~Zv dtP:erythrocyte differentiationsq~ZvdtP:monocyte differentiationsq~Zv7dt#P:apoptotic chromosome condensationsq~Zv]dtP:cholesterol transportsq~Zvdt'P:negative regulation of cell migrationsq~Zw&dt,P:negative regulation of bone mineralizationsq~Zw'dt&P:regulation of cell redox homeostasissq~ZydtP:neurite developmentsq~Z#dt0P:positive regulation of tyrosine phosphoryla...sq~Zdt0P:negative regulation of cytokine and chemoki...sq~Zdt0P:generation of precursor metabolites and energysq~ZEdt)P:pyrimidine nucleoside metabolic processsq~Z|dt"P:DNA unwinding during replicationsq~Z~dtP:DNA replication initiationsq~ZdtP:nucleotide-excision repairsq~ZdtP:postreplication repairsq~Zdt0P:double-strand break repair via nonhomologou...sq~ZdtP:DNA methylationsq~ZdtP:DNA recombinationsq~ZdtP:loss of chromatin silencingsq~ZWdt P:carbohydrate metabolic processsq~ZMdtP:DNA damage checkpointsq~ZRdt'P:G1/S transition of mitotic cell cyclesq~Z{dt0P:negative regulation of T cell mediated cyto...sq~Z-dt&P:epithelial to mesenchymal transitionsq~ZdtP:neural crest cell migrationsq~ZdtP:ovarian follicle developmentsq~ZdtP:angiogenesissq~ZdtP:skeletal developmentsq~Zdt0P:double-strand break repair via homologous r...sq~ZdtP:activation of MAPK activitysq~Zdt.P:establishment of mitotic spindle orientationsq~Zdt)P:negative regulation of neuron apoptosissq~ZdtP:transcriptionsq~Zdt P:apoptosissq~Zldt P:proteolysissq~Zmdt)P:membrane protein ectodomain proteolysissq~ZpdtP:ubiquitin cyclesq~ZdtP:protein targetingsq~ZdtP:mitochondrial transportsq~ZdtP:induction of apoptosissq~Zdt!P:cellular copper ion homeostas