sr -cic.cytoscape.plugin.util.CICPluginSesionData
L Bookmarkt Ljava/util/HashMap;L GlobEdgq ~ L GlobNodq ~ L Gonavq ~ L Helpnavq ~ L Hidedataq ~ L Interpronavt Ljava/lang/Object;L Metnavq ~ L Pfamnavq ~ L Positionq ~ xpsr java.util.HashMap` F
loadFactorI thresholdxp?@ w t 2sr java.util.Vectorٗ}[; I capacityIncrementI elementCount[ elementDatat [Ljava/lang/Object;xp ur [Ljava.lang.Object;Xs)l xp
ppppppppppxxsq ~ ?@ w t 2sq ~ ?@ `w ]t
BCL2 (3) BAXBsr databasemapping.Interaction!2g
I fromIdI idZ intraZ ipfamValI
numMethodsI procI toIdL bdReft Ljava/lang/String;L descriptionq ~ L fromSwissq ~ L intmetexpt Ljava/util/Vector;L procStrq ~ L toSwissq ~ xp pppsq ~ uq ~
sr databasemapping.IntmetexplK,C
I experimentIdI
interactionIdI methodIdI methodPubmedI
multipleIdI procL bdRefq ~ L descriptionq ~ L
methodDescq ~ L procStrq ~ xp u % t h HPRD t !Diaz JL et al. (1997) J Biol Chemt in vivot HPRD sq ~ u % t h HPRD t !Diaz JL et al. (1997) J Biol Chemt in vitrot HPRD sq ~ u Y t h HPRD t !Diaz JL et al. (1997) J Biol Chemt
two hybridt HPRD pppppppxt HPRD pt
BAXB (1) MCL1sq ~ pppsq ~ uq ~
sq ~ ] % t h HPRD t Bae J et al. (2000) J Biol Chemt in vivot HPRD pppppppppxt HPRD pt
BCLX (6) BCL2sq ~ pppsq ~ uq ~
sq ~ ! ' un t s IntAct t Bruey JM et al. (2007) Cellt anti bait coimmunoprecipitationt IntAct sq ~ ' % t h HPRD t Cheng EH et al. (2001) Mol Cellt in vivot HPRD sq ~ k ' un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT sq ~ | ' q % t b BioGRID t Lin B et al. (2004) Cellt western blott BioGRID sq ~ y ' Y t _ DIP t -Sato T et al. (1994) Proc Natl Acad Sci U S At
two hybridt DIP sq ~ 55 ' '" t b BioGRID t "Zhang H et al. (2002) Anal Biochemt Protein-peptidet BioGRID ppppxt %DIP - HPRD - IntAct - MINT - BioGRID pt SHLB1 (2) BAXAsq ~ h Ipppsq ~ uq ~
sq ~ 0 . Y t n MINT t &Cuddeback SM et al. (2001) J Biol Chemt
two hybridt MINT sq ~ 0 . un t n MINT t &Cuddeback SM et al. (2001) J Biol Chemt coimmunoprecipitationt MINT ppppppppxt MINT pt BAXB (1) VDAC1sq ~ J}pppsq ~ uq ~
sq ~ Ҹ % t h HPRD t .Shi Y et al. (2003) Biochem Biophys Res Communt in vivot HPRD pppppppppxt HPRD pt BAXA (1) BIMsq ~ I &bpppsq ~ uq ~
sq ~ k un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT pppppppppxt MINT pt
BCL2 (5) BCL2sq ~ pppsq ~ uq ~
sq ~ o x l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ fU x un t s IntAct t Huang DC et al. (1998) EMBO Jt anti tag coimmunoprecipitationt IntAct sq ~ x % t h HPRD t !Zhang Z et al. (2004) J Biol Chemt in vivot HPRD sq ~ x % t h HPRD t !Zhang Z et al. (2004) J Biol Chemt in vitrot HPRD sq ~ x Y t h HPRD t !Zhang Z et al. (2004) J Biol Chemt
two hybridt HPRD pppppxt HPRD - IntAct pt BAXA (4) HUNINsq ~ I pppsq ~ uq ~
sq ~ I Y t n MINT t Guo B et al. (2003) Naturet
two hybridt MINT sq ~ I 5 dk t n MINT t Guo B et al. (2003) Naturet &fluorescence polarization spectroscopyt MINT sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti tag coimmunoprecipitationt MINT sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti bait coimmunoprecipitationt MINT ppppppxt MINT pt HUNIN (1) B2L10sq ~ pppsq ~ uq ~
sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti tag coimmunoprecipitationt MINT pppppppppxt MINT pt 1433S (1) BAXAsq ~ Ipppsq ~ uq ~
sq ~ > un t n MINT t "Samuel T et al. (2001) J Biol Chemt coimmunoprecipitationt MINT pppppppppxt MINT pt
BID (5) B2LA1sq ~ .J .Epppsq ~ uq ~
sq ~ d ul 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z ul % t m BIND t Chen L et al. (2005) Mol Cellt molecular interactiont BIND sq ~ J ul 3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ ul % 0t BioGRID HPRD t #Werner AB et al. (2002) J Biol Chemt in vivot HPRD - BioGRID sq ~ ul % 0t BioGRID HPRD t #Werner AB et al. (2002) J Biol Chemt in vitrot HPRD - BioGRID pppppxt BIND - HPRD - IntAct - BioGRID pt
BBC3 (2) MCL1sq ~ ' pppsq ~ uq ~
sq ~ d un 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z un q % t d BioGRID t Chen L et al. (2005) Mol Cellt western blott BioGRID ppppppppxt IntAct - BioGRID pt MCL1 (4) BIMsq ~ &bpppsq ~ uq ~
sq ~ ] Y 0t BioGRID HPRD t Bae J et al. (2000) J Biol Chemt
two hybridt HPRD - BioGRID sq ~ z q % t b BioGRID t Chen L et al. (2005) Mol Cellt western blott BioGRID sq ~ k un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT sq ~ e un t n MINT t Warr MR et al. (2005) FEBS Lettt anti tag coimmunoprecipitationt MINT ppppppxt HPRD - MINT - BioGRID pt
BAK (3) B2LA1sq ~ ] .Epppsq ~ uq ~
sq ~ iN ǒ % 0t BioGRID HPRD t ,Holmgreen SP et al. (1999) Cell Death Differt in vivot HPRD - BioGRID sq ~ iN ǒ Y 0t BioGRID HPRD t ,Holmgreen SP et al. (1999) Cell Death Differt
two hybridt HPRD - BioGRID sq ~ J ǒ 3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID pppppppxt HPRD - BioGRID pt
B2LA1 (1) APRsq ~ .E 03pppsq ~ uq ~
sq ~ z H '" 8t7 BioGRID BIND HPRD t Chen L et al. (2005) Mol Cellt Protein-peptidet BIND - HPRD - BioGRID pppppppppxt BIND - HPRD - BioGRID pt B2L10 (1) BCLXsq ~ pppsq ~ uq ~
sq ~ . un t MINT HPRD t Ke N et al. (2001) J Biol Chemt coimmunoprecipitationt HPRD - MINT pppppppppxt HPRD - MINT pt BCLX (6) BIDsq ~ .Jpppsq ~ uq ~
sq ~ ? ux % t BIND HPRD t !Cartron PF et al. (2004) Mol Cellt molecular interactiont BIND - HPRD sq ~ d ux 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z ux k *tB IntAct BioGRID BIND t Chen L et al. (2005) Mol Cellt surface plasmon resonancet BIND - IntAct - BioGRID sq ~ o ux l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ J ux 3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ G ux % t m BIND t !Walensky LD et al. (2004) Sciencet molecular interactiont BIND ppppxt BIND - HPRD - IntAct - BioGRID pt MOAP1 (2) MOAP1sq ~ L Lpppsq ~ uq ~
sq ~ J
3 t d BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ Y
% t BIND HPRD t Tan KO et al. (2001) J Biol Chemt molecular interactiont BIND - HPRD ppppppppxt BIND - HPRD - BioGRID pt
BAK (1) B2L10sq ~ ] pppsq ~ uq ~
sq ~ , Y t h HPRD t Song Q et al. (1999) EMBO Jt
two hybridt HPRD pppppppppxt HPRD pt
BCLX (2) MCL1sq ~ pppsq ~ uq ~
sq ~ k un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT sq ~ y Y t _ DIP t -Sato T et al. (1994) Proc Natl Acad Sci U S At
two hybridt DIP ppppppppxt DIP - MINT pt BAK (4) BAKsq ~ ] ]pppsq ~ uq ~
sq ~ mm % t h HPRD t "Leo CP et al. (1999) Endocrinologyt in vitrot HPRD sq ~ q % t b BioGRID t "Leu JI et al. (2004) Nat Cell Biolt western blott BioGRID sq ~ un t s IntAct t !Willis SN et al. (2005) Genes Devt anti tag coimmunoprecipitationt IntAct sq ~ ˟ % t m BIND t Zhang L et al. (2005) Oncogenet molecular interactiont BIND ppppppxt BIND - HPRD - IntAct - BioGRID pt BAK (3) BCL2sq ~ ] pppsq ~ uq ~
sq ~ 3 n % 0t BioGRID HPRD t "Enyedy IJ et al. (2001) J Med Chemt in vitrot HPRD - BioGRID sq ~ fU n un t s IntAct t Huang DC et al. (1998) EMBO Jt anti bait coimmunoprecipitationt IntAct sq ~ | n q % t b BioGRID t Lin B et al. (2004) Cellt western blott BioGRID pppppppxt HPRD - IntAct - BioGRID pt MCL1 (4) BIDsq ~ .Jpppsq ~ uq ~
sq ~ d ur 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z ur '" t c BioGRID t Chen L et al. (2005) Mol Cellt Protein-peptidet BioGRID sq ~ ? ur q % 0t BioGRID HPRD t Weng C et al. (2005) J Biol Chemt western blott HPRD - BioGRID sq ~ ? ur ' 0t BioGRID HPRD t Weng C et al. (2005) J Biol Chemt Reconstituted Complext HPRD - BioGRID ppppppxt HPRD - IntAct - BioGRID pt BID (2) BAXBsq ~ .J pppsq ~ uq ~
sq ~ ? Y t h HPRD t !Cartron PF et al. (2004) Mol Cellt
two hybridt HPRD sq ~ ? % t h HPRD t !Cartron PF et al. (2004) Mol Cellt in vitrot HPRD ppppppppxt HPRD pt B2L10 (1) B2L10sq ~ pppsq ~ uq ~
sq ~ , Y t h HPRD t Song Q et al. (1999) EMBO Jt
two hybridt HPRD pppppppppxt HPRD pt
BAXC (4) BCL2sq ~ t pppsq ~ uq ~
sq ~ h\ w q % t b BioGRID t "Hoetelmans RW (2004) DNA Cell Biolt western blott BioGRID sq ~ | w ' t b BioGRID t Lin B et al. (2004) Cellt Reconstituted Complext BioGRID sq ~ | w q % t b BioGRID t Lin B et al. (2004) Cellt western blott BioGRID sq ~ w % t b BioGRID t Oltvai ZN et al. (1993) Cellt in vivot BioGRID ppppppxt BioGRID pt
BCLX (6) BAXAsq ~ Ipppsq ~ uq ~
sq ~ & un t s IntAct t #Chinnaiyan AM et al. (1997) Sciencet coimmunoprecipitationt IntAct sq ~ q & ` % t s IntAct t Chipuk JE et al. (2005) Sciencet pull downt IntAct sq ~ k & un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT sq ~ 3 & un t s IntAct t Jeong SY et al. (2004) EMBO Jt anti bait coimmunoprecipitationt IntAct sq ~ @ & t s IntAct t #Ottilie S et al. (1997) J Biol Chemt !enzyme linked immunosorbent assayt IntAct sq ~ L> & - % t ] DIP t Reed JC (1997) Naturet "experimental interaction detectiont DIP ppppxt DIP - IntAct - MINT pt
BCLX (3) BAXBsq ~ pppsq ~ uq ~
sq ~ K % t k BIND t !Diaz JL et al. (1997) J Biol Chemt molecular interactiont BIND sq ~ *J K % t BIND HPRD t $Hammond PW et al. (2001) J Biol Chemt molecular interactiont BIND - HPRD sq ~ K % t k BIND t Hsu YT et al. (1997) J Biol Chemt molecular interactiont BIND pppppppxt BIND - HPRD pt BAXC (2) 1433Tsq ~ t pppsq ~ uq ~
sq ~ M : % t b BioGRID t "Nomura M et al. (2003) J Biol Chemt in vivot BioGRID sq ~ M : % t b BioGRID t "Nomura M et al. (2003) J Biol Chemt in vitrot BioGRID ppppppppxt BioGRID pt
BCL2 (1) MCL1sq ~ pppsq ~ uq ~
sq ~ y Y t _ DIP t -Sato T et al. (1994) Proc Natl Acad Sci U S At
two hybridt DIP pppppppppxt DIP pt SHLB1 (1) SHLB1sq ~ h hpppsq ~ uq ~
sq ~ P Y 8t9 BioGRID BIND HPRD t Pierrat B et al. (2001) Genomicst
two hybridt BIND - HPRD - BioGRID pppppppppxt BIND - HPRD - BioGRID pt
ADT1 (2) BAXBsq ~ d\ pppsq ~ uq ~
sq ~ Y t h HPRD t Marzo I et al. (1998) Sciencet
two hybridt HPRD sq ~ % t h HPRD t Marzo I et al. (1998) Sciencet in vitrot HPRD ppppppppxt HPRD pt BAXA (2) BAKsq ~ I ]pppsq ~ uq ~
sq ~ ^ un t n MINT t (Sundararajan R et al. (2001) J Biol Chemt coimmunoprecipitationt MINT sq ~ un t s IntAct t !Willis SN et al. (2005) Genes Devt anti tag coimmunoprecipitationt IntAct ppppppppxt IntAct - MINT pt B2L10 (1) BCL2sq ~ pppsq ~ uq ~
sq ~ V un 4t8 MINT BioGRID HPRD t Ke N et al. (2001) J Biol Chemt coimmunoprecipitationt HPRD - MINT - BioGRID pppppppppxt HPRD - MINT - BioGRID pt HUNIN (1) BCL2sq ~ pppsq ~ uq ~
sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti tag coimmunoprecipitationt MINT pppppppppxt MINT pt
NOL3 (2) NOL3sq ~ 0 0pppsq ~ uq ~
sq ~ J w ` % 6t IntAct MINT BioGRID HPRD t Rual JF et al. (2005) Naturet pull downt HPRD - IntAct - MINT - BioGRID sq ~ J w ʪ 6t IntAct MINT BioGRID HPRD t Rual JF et al. (2005) Naturet two hybrid pooling approacht HPRD - IntAct - MINT - BioGRID ppppppppxt HPRD - IntAct - MINT - BioGRID pt APR (1) BAXCsq ~ 03 tpppsq ~ uq ~
sq ~ H q % t c BioGRID t Sun Y et al. (2005) J Biol Chemt western blott BioGRID pppppppppxt BioGRID pt HUNIN (1) HUNINsq ~ pppsq ~ uq ~
sq ~ % t h HPRD t %Terashita K et al. (2003) J Neurochemt in vivot HPRD pppppppppxt HPRD pt BID (2) BIDsq ~ .J .Jpppsq ~ uq ~
sq ~ ! ͢ % 0t BioGRID HPRD t $Grinberg M et al. (2002) J Biol Chemt in vivot HPRD - BioGRID sq ~ J ͢ 3 t c BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID ppppppppxt HPRD - BioGRID pt BAXB (1) 1433Ssq ~ pppsq ~ uq ~
sq ~ Y t h HPRD t "Samuel T et al. (2001) J Biol Chemt
two hybridt HPRD pppppppppxt HPRD pt
ADT1 (3) BAXCsq ~ d\ tpppsq ~ uq ~
sq ~ D % t d BioGRID t Marzo I et al. (1998) Sciencet in vivot BioGRID sq ~ D Y t d BioGRID t Marzo I et al. (1998) Sciencet
two hybridt BioGRID sq ~ J D 3 t d BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID pppppppxt BioGRID pt BCL2 (5) BIMsq ~ &bpppsq ~ uq ~
sq ~ z wt k "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt surface plasmon resonancet IntAct - BioGRID sq ~ z wt un "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt anti tag coimmunoprecipitationt IntAct - BioGRID sq ~
wt un t s IntAct t Deng J et al. (2007) Cancer Cellt anti bait coimmunoprecipitationt IntAct sq ~ o wt l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ f wt % 0t BioGRID HPRD t O'Connor L et al. (1998) EMBO Jt in vivot HPRD - BioGRID pppppxt HPRD - IntAct - BioGRID pt ERN1 (2) BAKsq ~ K, ]pppsq ~ uq ~
sq ~ * Y t h HPRD t Hetz C et al. (2006) Sciencet
two hybridt HPRD sq ~ * % t h HPRD t Hetz C et al. (2006) Sciencet in vivot HPRD ppppppppxt HPRD pt BAXB (1) B2L10sq ~ pppsq ~ uq ~
sq ~ Y t h HPRD t Ke N et al. (2001) J Biol Chemt
two hybridt HPRD pppppppppxt HPRD pt
BCLX (3) BCLXsq ~ pppsq ~ uq ~
sq ~ R Y t h HPRD t Inohara N et al. (1997) EMBO Jt
two hybridt HPRD sq ~ R % t h HPRD t Inohara N et al. (1997) EMBO Jt in vitrot HPRD sq ~ 3 un t s IntAct t Jeong SY et al. (2004) EMBO Jt anti tag coimmunoprecipitationt IntAct pppppppxt HPRD - IntAct pt 1433T (2) BAXBsq ~ pppsq ~ uq ~
sq ~ M Y t h HPRD t "Nomura M et al. (2003) J Biol Chemt
two hybridt HPRD sq ~ M % t h HPRD t "Nomura M et al. (2003) J Biol Chemt in vivot HPRD ppppppppxt HPRD pt BAXC (1) MOAP1sq ~ t Lpppsq ~ uq ~
sq ~ J
3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID pppppppppxt BioGRID pt
BCL2 (5) BAXAsq ~ Ipppsq ~ uq ~
sq ~ ` % t n MINT t !Diaz JL et al. (1997) J Biol Chemt pull downt MINT sq ~ k un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT sq ~ fU un t s IntAct t Huang DC et al. (1998) EMBO Jt anti bait coimmunoprecipitationt IntAct sq ~ @ t s IntAct t #Ottilie S et al. (1997) J Biol Chemt !enzyme linked immunosorbent assayt IntAct sq ~ L> - % t ^ DIP t Reed JC (1997) Naturet "experimental interaction detectiont DIP pppppxt DIP - IntAct - MINT pt BAK (3) BIDsq ~ ] .Jpppsq ~ uq ~
sq ~ Y t h HPRD t Wei MC et al. (2000) Genes Devt
two hybridt HPRD sq ~ % t h HPRD t Wei MC et al. (2000) Genes Devt in vivot HPRD sq ~ H t s IntAct t Yi X et al. (2003) J Biol Chemt 1protein cross-linking with a bifunctional reagentt IntAct pppppppxt HPRD - IntAct pt
BAXC (3) BCLXsq ~ t pppsq ~ uq ~
sq ~ J 3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ q % t b BioGRID t Strobel T et al. (1998) Oncogenet western blott BioGRID sq ~ 55 '" t b BioGRID t "Zhang H et al. (2002) Anal Biochemt Protein-peptidet BioGRID pppppppxt BioGRID pt SHLB1 (7) BAXCsq ~ h tpppsq ~ uq ~
sq ~ 0 F % t d BioGRID t &Cuddeback SM et al. (2001) J Biol Chemt in vivot BioGRID sq ~ 0 F % t d BioGRID t &Cuddeback SM et al. (2001) J Biol Chemt in vitrot BioGRID sq ~ 0 F Y t d BioGRID t &Cuddeback SM et al. (2001) J Biol Chemt
two hybridt BioGRID sq ~ P F % t d BioGRID t Pierrat B et al. (2001) Genomicst in vivot BioGRID sq ~ P F % t d BioGRID t Pierrat B et al. (2001) Genomicst in vitrot BioGRID sq ~ P F Y t d BioGRID t Pierrat B et al. (2001) Genomicst
two hybridt BioGRID sq ~ J F 3 t d BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID pppxt BioGRID pt BAXB (2) B2LA1sq ~ .Epppsq ~ uq ~
sq ~ z Y t h HPRD t !Zhang H et al. (2000) J Biol Chemt
two hybridt HPRD sq ~ z % t h HPRD t !Zhang H et al. (2000) J Biol Chemt in vitrot HPRD ppppppppxt HPRD pt BAXB (3) HUNINsq ~ pppsq ~ uq ~
sq ~ I % t h HPRD t Guo B et al. (2003) Naturet in vivot HPRD sq ~ I Y t h HPRD t Guo B et al. (2003) Naturet
two hybridt HPRD sq ~ I % t h HPRD t Guo B et al. (2003) Naturet in vitrot HPRD pppppppxt HPRD pt
NOL3 (1) BAXBsq ~ 0 pppsq ~ uq ~
sq ~ R Y t h HPRD t Nam YJ et al. (2004) Mol Cellt
two hybridt HPRD pppppppppxt HPRD pt HUNIN (1) BCLXsq ~ pppsq ~ uq ~
sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti tag coimmunoprecipitationt MINT pppppppppxt MINT pt 1433T (2) 1433Tsq ~ pppsq ~ uq ~
sq ~ 0 Y t h HPRD t Liu YC et al. (1996) J Biol Chemt
two hybridt HPRD sq ~ 0 % t h HPRD t Liu YC et al. (1996) J Biol Chemt in vivot HPRD ppppppppxt HPRD pt BAXC (1) B2L10sq ~ t pppsq ~ uq ~
sq ~ J % t b BioGRID t Ke N et al. (2001) J Biol Chemt in vivot BioGRID pppppppppxt BioGRID pt B2L10 (1) BAXAsq ~ Ipppsq ~ uq ~
sq ~ > un t n MINT t Ke N et al. (2001) J Biol Chemt coimmunoprecipitationt MINT pppppppppxt MINT pt
MCL1 (2) BAXAsq ~ Ipppsq ~ uq ~
sq ~ ] Y t n MINT t Bae J et al. (2000) J Biol Chemt
two hybridt MINT sq ~ k un t n MINT t Ewings KE et al. (2007) EMBO Jt anti bait coimmunoprecipitationt MINT ppppppppxt MINT pt
MCL1 (1) MCL1sq ~ pppsq ~ uq ~
sq ~ ] H % 0t BioGRID HPRD t Bae J et al. (2000) J Biol Chemt in vivot HPRD - BioGRID pppppppppxt HPRD - BioGRID pt B2LA1 (2) BBC3sq ~ .E 'pppsq ~ uq ~
sq ~ d ue 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z ue % t BIND HPRD t Chen L et al. (2005) Mol Cellt molecular interactiont BIND - HPRD ppppppppxt BIND - HPRD - IntAct pt BAXC (3) B2LA1sq ~ t .Epppsq ~ uq ~
sq ~ J H 3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ z H % t b BioGRID t !Zhang H et al. (2000) J Biol Chemt in vivot BioGRID sq ~ z H Y t b BioGRID t !Zhang H et al. (2000) J Biol Chemt
two hybridt BioGRID pppppppxt BioGRID pt BAK (2) BAXCsq ~ ] tpppsq ~ uq ~
sq ~ J G 3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ ^ G % t b BioGRID t (Sundararajan R et al. (2001) J Biol Chemt in vivot BioGRID ppppppppxt BioGRID pt
BAXA (1) BAXAsq ~ I Ipppsq ~ uq ~
sq ~ Ƒ - % t n MINT t %Krieger NS et al. (1992) Am J Physiolt "experimental interaction detectiont MINT pppppppppxt MINT pt BCLX (7) BIMsq ~ &bpppsq ~ uq ~
sq ~ R % 0t BioGRID HPRD t Bouillet P et al. (2002) Naturet in vivot HPRD - BioGRID sq ~ z R k "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt surface plasmon resonancet IntAct - BioGRID sq ~ z R un "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt anti bait coimmunoprecipitationt IntAct - BioGRID sq ~ z R un "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt anti tag coimmunoprecipitationt IntAct - BioGRID sq ~ o R l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ R c : "t IntAct BioGRID t &Whitfield J et al. (2003) Anal Biochemt scintillation proximity assayt IntAct - BioGRID sq ~ R \ "t IntAct BioGRID t &Whitfield J et al. (2003) Anal Biochemt &homogeneous time resolved fluorescencet IntAct - BioGRID pppxt HPRD - IntAct - BioGRID pt BBC3 (10) BCLXsq ~ '
pppsq ~
uq ~
sq ~ ? uf % t BIND HPRD t !Cartron PF et al. (2004) Mol Cellt molecular interactiont BIND - HPRD sq ~ d uf 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z uf k *tD IntAct BioGRID BIND t Chen L et al. (2005) Mol Cellt surface plasmon resonancet BIND - IntAct - BioGRID sq ~ z uf un *tD IntAct BioGRID BIND t Chen L et al. (2005) Mol Cellt anti tag coimmunoprecipitationt BIND - IntAct - BioGRID sq ~ q uf k t IntAct HPRD t Chipuk JE et al. (2005) Sciencet surface plasmon resonancet HPRD - IntAct sq ~ q uf ` % t IntAct HPRD t Chipuk JE et al. (2005) Sciencet pull downt HPRD - IntAct sq ~ q uf un t IntAct HPRD t Chipuk JE et al. (2005) Sciencet anti bait coimmunoprecipitationt HPRD - IntAct sq ~ o uf l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ ( uf % t m BIND t Kuwana T et al. (2005) Mol Cellt molecular interactiont BIND sq ~ uf un t a DIP t Zhao R et al. (2007) PLoS Biolt anti bait coimmunoprecipitationt DIP xt %BIND - DIP - HPRD - IntAct - BioGRID pt BAXB (3) SHLB1sq ~ hpppsq ~ uq ~
sq ~ 0 Y t h HPRD t &Cuddeback SM et al. (2001) J Biol Chemt
two hybridt HPRD sq ~ 0 % t h HPRD t &Cuddeback SM et al. (2001) J Biol Chemt in vivot HPRD sq ~ 0 % t h HPRD t &Cuddeback SM et al. (2001) J Biol Chemt in vitrot HPRD pppppppxt HPRD pt APR (2) BCL2sq ~ 03 pppsq ~ uq ~
sq ~ z u '" t c BioGRID t Chen L et al. (2005) Mol Cellt Protein-peptidet BioGRID sq ~ u % 0t BioGRID HPRD t Oda E et al. (2000) Sciencet in vivot HPRD - BioGRID ppppppppxt HPRD - BioGRID pt MCL1 (2) APRsq ~ 03pppsq ~ uq ~
sq ~ z q % 0t BioGRID HPRD t Chen L et al. (2005) Mol Cellt western blott HPRD - BioGRID sq ~ un "t IntAct BioGRID t !Willis SN et al. (2005) Genes Devt anti tag coimmunoprecipitationt IntAct - BioGRID ppppppppxt HPRD - IntAct - BioGRID pt
ERN1 (2) BAXBsq ~ K, pppsq ~ uq ~
sq ~ ) Y t h HPRD t Hetz C et al. (2006) Sciencet
two hybridt HPRD sq ~ ) % t h HPRD t Hetz C et al. (2006) Sciencet in vivot HPRD ppppppppxt HPRD pt BCLX (2) MOAP1sq ~ Lpppsq ~ uq ~
sq ~ J
3 t b BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ Y
% t BIND HPRD t Tan KO et al. (2001) J Biol Chemt molecular interactiont BIND - HPRD ppppppppxt BIND - HPRD - BioGRID pt
HUNIN (1) BAKsq ~ ]pppsq ~ uq ~
sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti tag coimmunoprecipitationt MINT pppppppppxt MINT pt BIM (1) BIMsq ~ &b &bpppsq ~ uq ~
sq ~ ~~ % t h HPRD t #Hsu SY et al. (1998) Mol Endocrinolt in vitrot HPRD pppppppppxt HPRD pt
BAK (14) BCLXsq ~ ] pppsq ~ uq ~
sq ~ F =s % 0t BioGRID HPRD t &Degterev A et al. (2001) Nat Cell Biolt in vivot HPRD - BioGRID sq ~ F =s % 0t BioGRID HPRD t &Degterev A et al. (2001) Nat Cell Biolt in vitrot HPRD - BioGRID sq ~ =s % t k BIND t &Griffiths GJ et al. (1999) J Cell Biolt molecular interactiont BIND sq ~ *J =s % t k BIND t $Hammond PW et al. (2001) J Biol Chemt molecular interactiont BIND sq ~ =s % t k BIND t %Holinger EP et al. (1999) J Biol Chemt molecular interactiont BIND sq ~ J =s ʪ "t IntAct BioGRID t Rual JF et al. (2005) Naturet two hybrid pooling approacht IntAct - BioGRID sq ~ =s % t k BIND t Sattler M et al. (1997) Sciencet molecular interactiont BIND sq ~ =s un t _ DIP t "Simonian PL et al. (1997) Oncogenet coimmunoprecipitationt DIP sq ~ =s c : "t IntAct BioGRID t &Whitfield J et al. (2003) Anal Biochemt scintillation proximity assayt IntAct - BioGRID sq ~ =s \ "t IntAct BioGRID t &Whitfield J et al. (2003) Anal Biochemt &homogeneous time resolved fluorescencet IntAct - BioGRID sq ~ =s un "t IntAct BioGRID t !Willis SN et al. (2005) Genes Devt anti bait coimmunoprecipitationt IntAct - BioGRID sq ~ =s un "t IntAct BioGRID t !Willis SN et al. (2005) Genes Devt anti tag coimmunoprecipitationt IntAct - BioGRID sq ~ =s k "t IntAct BioGRID t !Willis SN et al. (2005) Genes Devt surface plasmon resonancet IntAct - BioGRID sq ~ 55 =s '" t b BioGRID t "Zhang H et al. (2002) Anal Biochemt Protein-peptidet BioGRID ppppppxt %BIND - DIP - HPRD - IntAct - BioGRID pt
BBC3 (5) BCL2sq ~ ' pppsq ~ uq ~
sq ~ d u{ 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z u{ k *tD IntAct BioGRID BIND t Chen L et al. (2005) Mol Cellt surface plasmon resonancet BIND - IntAct - BioGRID sq ~ z u{ un *tD IntAct BioGRID BIND t Chen L et al. (2005) Mol Cellt anti tag coimmunoprecipitationt BIND - IntAct - BioGRID sq ~ o u{ l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ u{ un 2t? IntAct BioGRID HPRD t Nakano K et al. (2001) Mol Cellt anti tag coimmunoprecipitationt HPRD - IntAct - BioGRID pppppxt BIND - HPRD - IntAct - BioGRID pt
BIM (1) VDAC1sq ~ &b J}pppsq ~ uq ~
sq ~ e Ҽ % 0t BioGRID HPRD t !Sugiyama T et al. (2002) Oncogenet in vivot HPRD - BioGRID pppppppppxt HPRD - BioGRID pt APR (3) BCLXsq ~ 03 pppsq ~ uq ~
sq ~ z wz un "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt anti tag coimmunoprecipitationt IntAct - BioGRID sq ~ z wz k "t IntAct BioGRID t Chen L et al. (2005) Mol Cellt surface plasmon resonancet IntAct - BioGRID sq ~ wz % 0t BioGRID HPRD t Oda E et al. (2000) Sciencet in vivot HPRD - BioGRID pppppppxt HPRD - IntAct - BioGRID pt HUNIN (1) MCL1sq ~ pppsq ~ uq ~
sq ~ I un t n MINT t Guo B et al. (2003) Naturet anti tag coimmunoprecipitationt MINT pppppppppxt MINT pt BAXB (1) BAKsq ~ ]pppsq ~ uq ~
sq ~ ^ Y t h HPRD t (Sundararajan R et al. (2001) J Biol Chemt
two hybridt HPRD pppppppppxt HPRD pt BID (7) BCL2sq ~ .J pppsq ~ uq ~
sq ~ d u 5 dk t s IntAct t !Certo M et al. (2006) Cancer Cellt &fluorescence polarization spectroscopyt IntAct sq ~ z u '" (t BioGRID BIND t Chen L et al. (2005) Mol Cellt Protein-peptidet BIND - BioGRID sq ~ o u l % t s IntAct t +Hermjakob H et al. (2004) Nucleic Acids Rest inferred by curatort IntAct sq ~ fU u un t s IntAct t Huang DC et al. (1998) EMBO Jt anti bait coimmunoprecipitationt IntAct sq ~ n u % 0t BioGRID HPRD t Luo X et al. (1998) Cellt in vitrot HPRD - BioGRID sq ~ u '" t b BioGRID t Real PJ et al. (2004) Cancer Rest Protein-peptidet BioGRID sq ~ u un t s IntAct t Yi X et al. (2003) J Biol Chemt coimmunoprecipitationt IntAct pppxt BIND - HPRD - IntAct - BioGRID pt MCL1 (1) VDAC1sq ~ J}pppsq ~ uq ~
sq ~ ? M ' 0t BioGRID HPRD t Weng C et al. (2005) J Biol Chemt Reconstituted Complext HPRD - BioGRID pppppppppxt HPRD - BioGRID pt
BBC3 (1) BAXBsq ~ ' pppsq ~ uq ~
sq ~ ? % t h HPRD t !Cartron PF et al. (2004) Mol Cellt in vitrot HPRD pppppppppxt HPRD pt
VDAC1 (3) BAKsq ~ J} ]pppsq ~ uq ~
sq ~ 4 un t n MINT t /Narita M et al. (1998) Proc Natl Acad Sci U S At coimmunoprecipitationt MINT sq ~ 4 ` % t n MINT t /Narita M et al. (1998) Proc Natl Acad Sci U S At pull downt MINT sq ~ W % t h HPRD t 0Shimizu S et al. (2000) Proc Natl Acad Sci U S At in vivot HPRD pppppppxt HPRD - MINT pt VDAC1 (3) BAXCsq ~ J} tpppsq ~ uq ~
sq ~ J I 3 t d BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ Ҹ I % t d BioGRID t .Shi Y et al. (2003) Biochem Biophys Res Communt in vitrot BioGRID sq ~ ? I ' t d BioGRID t Weng C et al. (2005) J Biol Chemt Reconstituted Complext BioGRID pppppppxt BioGRID pt
MCL1 (1) BAXCsq ~ tpppsq ~ uq ~
sq ~ ] I % t c BioGRID t Bae J et al. (2000) J Biol Chemt in vitrot BioGRID pppppppppxt BioGRID pt BAXB (1) APRsq ~ 03pppsq ~ uq ~
sq ~ Y t h HPRD t Sun Y et al. (2005) J Biol Chemt
two hybridt HPRD pppppppppxt HPRD pt
ERN1 (1) ERN1sq ~ K, K,pppsq ~ uq ~
sq ~ _ % 0t BioGRID HPRD t Liu CY et al. (2003) J Biol Chemt in vitrot HPRD - BioGRID pppppppppxt HPRD - BioGRID pt 1433T (1) 1433Ssq ~ pppsq ~ uq ~
sq ~ un t s IntAct t "Brandt M et al. (2006) Chembiochemt "affinity chromatography technologyt IntAct pppppppppxt IntAct pt BAXB (2) MOAP1sq ~ Lpppsq ~ uq ~
sq ~ Y Y t h HPRD t Tan KO et al. (2001) J Biol Chemt
two hybridt HPRD sq ~ Y % t h HPRD t Tan KO et al. (2001) J Biol Chemt in vivot HPRD ppppppppxt HPRD pt VDAC1 (5) BCLXsq ~ J} pppsq ~ uq ~
sq ~ X @ % t d BioGRID t 2Messina A et al. (1999) Biochem Biophys Res Communt in vivot BioGRID sq ~ J @ 3 t d BioGRID t Rual JF et al. (2005) Naturet tandem affinity purificationt BioGRID sq ~ ,
@ % 0t BioGRID HPRD t Shimizu S et al. (1999) Naturet in vivot HPRD - BioGRID sq ~ | @ % t d BioGRID t 0Shimizu S et al. (2000) Proc Natl Acad Sci U S At in vivot BioGRID sq ~ ? @ ' t d BioGRID t Weng C et al. (2005) J Biol Chemt Reconstituted Complext BioGRID pppppxt HPRD - BioGRID pt MOAP1 (1) BCL2sq ~ L pppsq ~ uq ~
sq ~ Y k % 8t9 BioGRID BIND HPRD t Tan KO et al. (2001) J Biol Chemt in vivot BIND - HPRD - BioGRID pppppppppxt BIND - HPRD - BioGRID pt 1433S (1) 1433Ssq ~ pppsq ~ uq ~
sq ~ ¡ d 3 t n MINT t -Benzinger A et al. (2005) Mol Cell Proteomicst tandem affinity purificationt MINT pppppppppxt MINT pt
BAK (10) MCL1sq ~ ]
pppsq ~
uq ~
sq ~ ] > Y 4t8 MINT BioGRID HPRD t Bae J et al. (2000) J Biol Chemt
two hybridt HPRD - MINT - BioGRID sq ~ X > un t s IntAct t %Konopleva M et al. (2006) Cancer Cellt anti bait coimmunoprecipitationt IntAct sq ~ mm > % t b BioGRID t "Leo CP et al. (1999) Endocrinologyt in vivot BioGRID sq ~ mm > % t b BioGRID t "Leo CP et al. (1999) Endocrinologyt in vitrot BioGRID sq ~ mm > Y t b BioGRID t "Leo CP et al. (1999) Endocrinologyt
two hybridt BioGRID sq ~ > ' t b BioGRID t "Leu JI et al. (2004) Nat Cell Biolt Reconstituted Complext BioGRID sq ~ > q % t b BioGRID t "Leu JI et al. (2004) Nat Cell Biolt western blott BioGRID sq ~ ? > ' t b BioGRID t Weng C et al. (2005) J Biol Chemt Reconstituted Complext BioGRID sq ~ > un "t IntAct BioGRID t !Willis SN et al. (2005) Genes Devt anti bait coimmunoprecipitationt IntAct - BioGRID sq ~ > un "t IntAct BioGRID t !Willis SN et al. (2005) Genes Devt anti tag coimmunoprecipitationt IntAct - BioGRID xt HPRD - IntAct - MINT - BioGRID pxxsq ~ ?@ w q ~
sq ~ ?@ w t BIDsr databasemapping.ProteinuWSR D clustercoefI connectcoefI idI numintI taxonIdL descriptionq ~ L ensq ~ L gensq ~ L goStatsq ~ L gosq ~ L interq ~ L pfamsq ~ L swissIdq ~ L swissNameq ~ L synonimsq ~ L taxonNameq ~ xp? ! .J " %t $BH3-interacting domain death agonistsq ~ uq ~
sr databasemapping.UniEnQW)U I idL ensIdq ~ xp .Jt ENSG00000015475pppppppppxsq ~ uq ~
sr databasemapping.UniGennGs+w I idC typeL genIdq ~ xp .J t BIDpppppppppxsq ~ zuq ~
sr databasemapping.GoStat> I goIdZ knowI numI proteinIdI rootL descriptionq ~ xp s .J t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ .J t P:anti-apoptosissq ~ .J t P:induction of apoptosissq ~ .J t P:signal transductionsq ~ , .J t +P:release of cytochrome c from mitochondriasq ~ l .J t
P:proteolysissq ~ .J t (P:regulation of protein homodimerizationsq ~ ! .J t P:apoptotic programsq ~ .J t P:cell motilitysq ~ D .J t $P:protein amino acid phosphorylationsq ~ .J t *P:regulation of protein heterodimerizationsq ~ 6 .J t 0P:regulation of mitochondrial membrane permea...sq ~ ʩ .J t 0P:regulation of mitochondrial membrane potentialsq ~ ! .J t 0P:induction of apoptosis via death domain rec...sq ~ ! .J t 0P:negative regulation of survival gene produc...sq ~
.J t P:cleavage of laminsq ~ % .J t P:response to toxinsq ~ ( .J t 0P:establishment and/or maintenance of transme...sq ~ v8 .J t (P:nuclear fragmentation during apoptosissq ~ \ .J t +P:positive regulation of cell proliferationsq ~ : .J t "P:negative regulation of apoptosissq ~ .J t 0P:cell surface receptor linked signal transdu...sq ~ b .J t !P:Rho protein signal transductionsq ~ I .J t !P:actin filament bundle formationsq ~ v .J t P:spermatid developmentsq ~ k .J t &P:multicellular organismal developmentsq ~ .J t P:female pregnancysq ~ u .J t P:mitochondrial fusionsq ~ < .J t P:protein homooligomerizationsq ~ s .J t P:spermatogenesissq ~ R .J t )P:activation of NF-kappaB-inducing kinasesq ~ .J t P:neuron apoptosissq ~ ɗ .J t P:defense response to virussq ~ c .J t P:cell-cell signalingsq ~ $ .J t P:response to UVsq ~ Z .J t P:JUN phosphorylationsq ~ .J t P:response to nicotinesq ~ !` .J t P:epidermis developmentsq ~ .J t .P:mitochondrial fragmentation during apoptosissq ~ j .J t 0P:positive regulation of NF-kappaB import int...sq ~ .J t -P:release of matrix enzymes from mitochondriasq ~ P .J t .P:negative regulation of cellular pH reductionsq ~ ʾ .J t 0P:negative regulation of mitochondrial depola...sq ~ .J t )P:positive regulation of neuron apoptosissq ~ M
.J t P:cellular homeostasissq ~ K .J t 0P:cytokine and chemokine mediated signaling p...sq ~ '7 .J t P:response to iron ionsq ~ R .J t ,P:induction of retinal programmed cell deathsq ~ $b .J t P:response to radiationsq ~ ! .J t %P:caspase activation via cytochrome csq ~ ! .J t 0P:induction of apoptosis by intracellular sig...sq ~ uT .J t 0P:actin cytoskeleton organization and biogenesissq ~ ! .J t 0P:induction of apoptosis by extracellular sig...sq ~ ) .J t .P:positive regulation of inflammatory responsesq ~ .J t &P:negative regulation of cell adhesionsq ~ x .J t 0P:positive regulation of transcription from R...sq ~ .J t P:B cell apoptosissq ~ .J t P:cell fate determinationsq ~ J .J t .P:regulation of progression through cell cyclesq ~ .J t P:DNA repairsq ~ .J t $P:DNA fragmentation during apoptosissq ~ = .J t P:protein complex assemblysq ~ % .J t !P:prostaglandin metabolic processsq ~ .J t P:apoptosissq ~ .J t P:caspase activationsq ~ .J t P:transformed cell apoptosissq ~ & .J t P:response to stresssq ~ / .J t P:humoral immune responsesq ~ h .J t P:cytoskeletal anchoringsq ~
.J t F:protein bindingsq ~ 2 .J t F:identical protein bindingsq ~ w .J t F:caspase activitysq ~ .J t F:signal transducer activitysq ~ .J t %F:protein heterodimerization activitysq ~ J .J t F:protein kinase CK2 activitysq ~ I .J t F:casein kinase I activitysq ~ 3 .J t #F:protein homodimerization activitysq ~ .J t F:receptor activitysq ~ .J t F:BH3 domain bindingsq ~ .J t F:receptor bindingsq ~ } .J t F:protein N-terminus bindingsq ~ ! .J t F:caspase activator activitysq ~ e .J t F:protein self-associationsq ~ t .J t F:transcription factor activitysq ~ .J t )F:Rho GDP-dissociation inhibitor activitysq ~ ! .J t 'F:protein kinase CK2 regulator activitysq ~ .J t F:protease bindingsq ~ T .J t F:GTPase activitysq ~ .J t )F:tumor necrosis factor receptor activitysq ~ .J t F:TRAIL bindingsq ~ .J t F:granzyme B activitysq ~ a .J t F:JUN kinase activitysq ~ .J t F:death receptor bindingsq ~ P .J t (F:structural constituent of cytoskeletonsq ~ G .J t F:actin filament bindingsq ~ M .J t F:enzyme bindingsq ~ a .J t F:lipid bindingsq ~ ; .J t F:protein channel activitysq ~ .J t C:cytoskeletonsq ~ .J t C:cytosolsq ~ .J t C:nucleussq ~ m .J t C:mitochondrial outer membranesq ~ .J t C:plasma membranesq ~ k .J t C:mitochondrionsq ~ .J t C:integral to plasma membranesq ~ .J t C:rufflesq ~ .J t C:immunological synapsesq ~ D .J t C:protein kinase CK2 complexsq ~ | .J t C:nuclear membranesq ~ .J t
C:microvillussq ~ W .J t !C:perinuclear region of cytoplasmsq ~ R .J t C:pore complexsq ~ } .J t 0C:mitochondrial permeability transition pore ...sq ~ i .J t C:cytoplasmsq ~ > .J t C:integral to membranesq ~ .J t C:soluble fractionsq ~ .J t C:intracellularsq ~ M .J t C:extrinsic to membranesq ~ .J t C:extracellular regionsq ~ .J t C:actin filamentsq ~ x .J t C:cortical cytoskeletonsq ~ .J t C:endoplasmic reticulum membraneppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sr databasemapping.UniGo2u|- I idI rootL descriptionq ~ L goIdq ~ xp .J t 0P:induction of apoptosis via death domain rec...t 8625sq ~ .J t P:neuron apoptosist 51402sq ~ .J t +P:release of cytochrome c from mitochondriat 1836sq ~ .J t F:death receptor bindingt 5123sq ~ .J t C:cytosolt 5829sq ~ .J t C:membrane fractiont 5624sq ~ .J t C:mitochondriont 5739pppxsq ~ uq ~
sr databasemapping.UniIntere I idL interIdq ~ L nameq ~ xp .Jt IPR000712t Bcl2_BHsq ~ .Jt IPR010479t BIDppppppppxsq ~ uq ~
sr databasemapping.UniPfamZ2ߝS I idL nameq ~ L pfamIdq ~ xp .Jt BIDt PF06393pppppppppxt P55957t BID_HUMANsq ~ uq ~
sr databasemapping.UniSynonimSZ- I proteinIdL descriptionq ~ xp .Jt BIDsq ~ .Jt p22 BIDsq ~ .Jt (BH3-interacting domain death agonist p15sq ~ .Jt p15 BIDsq ~ .Jt (BH3-interacting domain death agonist p13sq ~ .Jt p13 BIDsq ~ .Jt (BH3-interacting domain death agonist p11sq ~ .Jt p11 BIDppxt Homo sapienst ADT1sq ~?| d\ %t ADP/ATP translocase 1sq ~ uq ~
sq ~ d\t ENSG00000151729pppppppppxsq ~ uq ~
sq ~ d\ t SLC25A4sq ~ d\ t ANT1ppppppppxsq ~ Buq ~
Psq ~ d\ t P:signal transductionsq ~ ! d\ t 0P:negative regulation of survival gene produc...sq ~ ! d\ t 0P:induction of apoptosis by extracellular sig...sq ~ ʩ d\ t 0P:regulation of mitochondrial membrane potentialsq ~ d\ t P:induction of apoptosissq ~ ! d\ t 0P:induction of apoptosis by intracellular sig...sq ~ [ d\ t P:cell proliferationsq ~ u d\ t P:mitochondrial fusionsq ~ | d\ t P:sex differentiationsq ~ d\ t P:brain developmentsq ~ q d\ t P:germ cell developmentsq ~ c d\ t P:cell-cell signalingsq ~ U d\ t 'P:cytoplasmic sequestering of NF-kappaBsq ~ ! d\ t %P:caspase activation via cytochrome csq ~ ! d\ t !P:apoptotic mitochondrial changessq ~ < d\ t P:protein homooligomerizationsq ~ R d\ t ,P:induction of retinal programmed cell deathsq ~ d\ t .P:mitochondrial fragmentation during apoptosissq ~ d\ t *P:regulation of protein heterodimerizationsq ~ d\ t (P:regulation of protein homodimerizationsq ~ d\ t $P:negative regulation of DNA bindingsq ~ d\ t -P:release of matrix enzymes from mitochondriasq ~ x d\ t P:prostate gland developmentsq ~ v8 d\ t (P:nuclear fragmentation during apoptosissq ~ > d\ t
P:cell growthsq ~ ( d\ t 0P:establishment and/or maintenance of transme...sq ~ % d\ t P:response to toxinsq ~ m d\ t P:tubulin foldingsq ~ d\ t P:transformed cell apoptosissq ~ , d\ t +P:release of cytochrome c from mitochondriasq ~ d\ t )P:positive regulation of neuron apoptosissq ~ d\ t P:B cell apoptosissq ~ d\ t $P:DNA fragmentation during apoptosissq ~ d\ t P:transcription, DNA-dependentsq ~ d\ t /P:transcription from RNA polymerase II promotersq ~
d\ t P:cleavage of laminsq ~ d\ t P:apoptosissq ~ d\ t P:transportsq ~ D d\ t $P:protein amino acid phosphorylationsq ~ d\ t F:protein bindingsq ~ t d\ t F:transcription factor activitysq ~ a d\ t F:lipid bindingsq ~ d\ t "F:glucocorticoid receptor activitysq ~ d\ t F:androgen receptor activitysq ~ Y d\ t F:protein kinase C activitysq ~ d\ t F:GTPase inhibitor activitysq ~ d\ t )F:phosphoglycerate dehydrogenase activitysq ~ d\ t %F:protein heterodimerization activitysq ~ d\ t F:protein dimerization activitysq ~ s d\ t F:NF-kappaB bindingsq ~ d\ t F:BH3 domain bindingsq ~ 3 d\ t #F:protein homodimerization activitysq ~ d\ t )F:tumor necrosis factor receptor activitysq ~ { d\ t "F:ubiquitin protein ligase bindingsq ~ #_ d\ t F:electron carrier activitysq ~ y d\ t F:androgen bindingsq ~ > d\ t F:cyclosporin A bindingsq ~ d\ t 'F:nuclear localization sequence bindingsq ~ d\ t C:nucleussq ~ i d\ t C:cytoplasmsq ~ d\ t C:membrane fractionsq ~ d\ t C:extracellular regionsq ~ } d\ t 0C:mitochondrial permeability transition pore ...sq ~ d\ t C:mitochondrial matrixsq ~ d\ t C:endoplasmic reticulum membranesq ~ d\ t C:cytosolppppppppppppppxsq ~ uq ~
sq ~ d\ t 0P:generation of precursor metabolites and energyt 6091sq ~ d\ t "P:mitochondrial genome maintenancet 2sq ~ d\ t P:transportt 6810sq ~ d\ t ,F:adenine transmembrane transporter activityt 15207sq ~ d\ t C:integral to plasma membranet 5887sq ~ d\ t C:mitochondriont 5739ppppxsq ~ uq ~
sq ~ d\t IPR002113t Aden_trnslctorsq ~ d\t IPR002067t Mit_carriersq ~ d\t IPR002030t Mit_uncouplingsq ~ d\t IPR001993t Mitoch_carrierppppppxsq ~ uq ~
sq ~ d\t Mito_carrt PF00153pppppppppxt P12235t
ADT1_HUMANsq ~ uq ~
sq ~ d\t !Adenine nucleotide translocator 1sq ~ d\t ANT 1sq ~ d\t ADP,ATP carrier protein 1sq ~ d\t !Solute carrier family 25 member 4sq ~ d\t 9ADP,ATP carrier protein, heart/skeletal muscle isoform T1pppppxt Homo sapienst BAKsq ~?] " ] # %t "Bcl-2 homologous antagonist/killersq ~ uq ~
sq ~ ]t ENSG00000030110pppppppppxsq ~ uq ~
sq ~ ] t BAK1sq ~ ] t BAKsq ~ ] t BCL2L7sq ~ ] t CDN1ppppppxsq ~ }uq ~
sq ~ ] t P:anti-apoptosissq ~ , ] t +P:release of cytochrome c from mitochondriasq ~ ] t (P:regulation of protein homodimerizationsq ~ 6 ] t 0P:regulation of mitochondrial membrane permea...sq ~ ! ] t 0P:negative regulation of survival gene produc...sq ~ ] t *P:regulation of protein heterodimerizationsq ~ k ] t &P:multicellular organismal developmentsq ~ ʩ ] t 0P:regulation of mitochondrial membrane potentialsq ~ % ] t P:response to toxinsq ~ ! ] t 0P:induction of apoptosis by extracellular sig...sq ~ ] t P:neuron apoptosissq ~ ] t P:anion transportsq ~ ! ] t %P:caspase activation via cytochrome csq ~ ] t P:cell cycle arrestsq ~ $b ] t P:response to radiationsq ~ ! ] t P:apoptotic programsq ~ ] t $P:DNA fragmentation during apoptosissq ~ ] t P:caspase activationsq ~ ] t P:induction of apoptosissq ~ ] t )P:positive regulation of neuron apoptosissq ~ ! ] t 0P:induction of apoptosis via death domain rec...sq ~ [ ] t P:cell proliferationsq ~ ! ] t 0P:induction of apoptosis by intracellular sig...sq ~ !` ] t P:epidermis developmentsq ~ ] t P:protein localizationsq ~ K ] t 0P:unfolded protein response, activation of si...sq ~ ] t P:cell agingsq ~ ] t P:female pregnancysq ~ ] t P:brain developmentsq ~ u ] t P:mitochondrial fusionsq ~ s ] t P:spermatogenesissq ~ q ] t P:germ cell developmentsq ~ | ] t P:female gamete generationsq ~ ] t P:cellular iron ion homeostasissq ~ ] t P:regulation of apoptosissq ~ ʾ ] t 0P:negative regulation of mitochondrial depola...sq ~ ] t )P:negative regulation of neuron apoptosissq ~ ] t .P:mitochondrial fragmentation during apoptosissq ~ ] t 'P:positive regulation of anti-apoptosissq ~ R ] t ,P:induction of retinal programmed cell deathsq ~ Ǚ ] t *P:negative regulation of helicase activitysq ~ < ] t P:protein homooligomerizationsq ~ > ] t P:protein tetramerizationsq ~ ] t 0P:DNA damage response, signal transduction by...sq ~ ] t )P:cellular response to glucose starvationsq ~ ] t P:response to nicotinesq ~ ! ] t !P:apoptotic mitochondrial changessq ~ w ] t P:leukocyte chemotaxissq ~ '7 ] t P:response to iron ionsq ~ ( ] t 0P:establishment and/or maintenance of transme...sq ~ M
] t P:cellular homeostasissq ~ u ] t *P:protein import into mitochondrial matrixsq ~ v8 ] t (P:nuclear fragmentation during apoptosissq ~ vd ] t $P:negative regulation of cell growthsq ~ ] t -P:release of matrix enzymes from mitochondriasq ~ ɗ ] t P:defense response to virussq ~ J ] t P:response to unfolded proteinsq ~ G ] t P:ER overload responsesq ~ ] t P:B cell apoptosissq ~ J ] t .P:regulation of progression through cell cyclesq ~ ] t P:base-excision repairsq ~ P ] t .P:negative regulation of cellular pH reductionsq ~ ] t P:nucleotide-excision repairsq ~ ] t ,P:regulation of transcription, DNA-dependentsq ~ ] t P:rRNA processingsq ~ 9 ] t P:protein foldingsq ~ D ] t $P:protein amino acid phosphorylationsq ~ o ] t /P:ubiquitin-dependent protein catabolic processsq ~
] t P:cleavage of laminsq ~ ] t P:transformed cell apoptosissq ~ ] t P:cell motilitysq ~ / ] t P:humoral immune responsesq ~ ] t P:cell fate determinationsq ~ ] t F:protein bindingsq ~ ] t %F:protein heterodimerization activitysq ~ ] t
F:ATP bindingsq ~ 3 ] t #F:protein homodimerization activitysq ~ ] t F:BH3 domain bindingsq ~ 2 ] t F:identical protein bindingsq ~ Y< ] t &F:voltage-gated anion channel activitysq ~ ] t F:signal transducer activitysq ~ ] t
F:RNA bindingsq ~ B ] t *F:protein serine/threonine kinase activitysq ~ P ] t (F:structural constituent of cytoskeletonsq ~ ] t .F:caspase-activated deoxyribonuclease activitysq ~ S ] t (F:cAMP-dependent protein kinase activitysq ~ ] t F:endoribonuclease activitysq ~ ] t F:nuclease activitysq ~ ] t F:protease bindingsq ~ t ] t F:transcription factor activitysq ~ ] t F:DNA strand annealing activitysq ~ NJ ] t F:unfolded protein bindingsq ~ ] t F:receptor antagonist activitysq ~ } ] t F:protein N-terminus bindingsq ~ ] t F:death receptor bindingsq ~ ] t F:magnesium ion bindingsq ~ Ǐ ] t F:chaperone bindingsq ~ ] t F:copper ion bindingsq ~ ] t F:lamin bindingsq ~ a ] t F:lipid bindingsq ~ N ] t F:zinc ion bindingsq ~ M ] t F:enzyme bindingsq ~ ; ] t F:protein channel activitysq ~ ] t
F:GTP bindingsq ~ k ] t C:mitochondrionsq ~ m ] t C:mitochondrial outer membranesq ~ ] t C:cytosolsq ~ ] t C:membrane fractionsq ~ ] t C:Arp2/3 protein complexsq ~ ] t C:intermediate filamentsq ~ ] t C:endoplasmic reticulum membranesq ~ ] t C:endoplasmic reticulumsq ~ } ] t 0C:mitochondrial permeability transition pore ...sq ~ ] t C:extracellular regionsq ~ ] t C:intracellularsq ~ W ] t !C:perinuclear region of cytoplasmsq ~ u ] t ,C:integral to endoplasmic reticulum membranesq ~ ] t C:insoluble fractionsq ~ ? ] t C:nuclear matrixsq ~ ] t C:nucleussq ~ R ] t C:pore complexsq ~ | ] t C:nuclear membranesq ~ ] t
C:nucleoplasmsq ~ b ] t C:nucleolussq ~ ] t C:nuclear envelopepppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ ] t +P:release of cytochrome c from mitochondriat 1836sq ~ ] t (P:regulation of protein homodimerizationt 43496sq ~ ] t *P:regulation of protein heterodimerizationt 43497sq ~ ] t 0P:regulation of mitochondrial membrane potentialt 51881sq ~ ] t 0P:regulation of mitochondrial membrane permea...t 46902sq ~ ] t P:induction of apoptosist 6917sq ~ ] t 0P:establishment and/or maintenance of transme...t 10248sq ~ ] t %F:protein heterodimerization activityt 46982sq ~ ] t F:identical protein bindingt 42802sq ~ ] t C:pore complext 46930sq ~ ] t C:mitochondriont 5739pppppppppxsq ~ uq ~
sq ~ ]t IPR012238t
Bcl2_apop_regsq ~ ]t IPR002475t
BCL2_apoptsissq ~ ]t IPR000712t Bcl2_BHpppppppxsq ~ uq ~
sq ~ ]t Bcl-2t PF00452pppppppppxt Q16611t BAK_HUMANsq ~ uq ~
sq ~ ]t Apoptosis regulator BAKsq ~ ]t Bcl-2-like 7 proteinppppppppxt Homo sapienst NOL3sq ~? , 0 %t Nucleolar protein 3sq ~ uq ~
sq ~ 0t ENSG00000140939pppppppppxsq ~ uq ~
sq ~ 0 t NOL3sq ~ 0 t ARCsq ~ 0 t NOPpppppppxsq ~ Fuq ~
Psq ~ ! 0 t P:apoptotic programsq ~ l 0 t
P:proteolysissq ~ s 0 t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ % 0 t P:response to toxinsq ~ C 0 t P:response to oxidative stresssq ~ 0 t P:transformed cell apoptosissq ~
0 t P:cleavage of laminsq ~ D 0 t $P:protein amino acid phosphorylationsq ~ 0 t P:mRNA splice site selectionsq ~ 0 t $P:DNA fragmentation during apoptosissq ~ 0 t P:cell adhesionsq ~ 0 t P:signal transductionsq ~ $b 0 t P:response to radiationsq ~ ! 0 t %P:caspase activation via cytochrome csq ~ ! 0 t 0P:negative regulation of survival gene produc...sq ~ ( 0 t 0P:establishment and/or maintenance of transme...sq ~ ! 0 t 0P:induction of apoptosis by intracellular sig...sq ~ ! 0 t 0P:induction of apoptosis by extracellular sig...sq ~ ? 0 t P:dephosphorylationsq ~ u 0 t P:mitochondrial fusionsq ~ u 0 t P:DNA-dependent DNA replicationsq ~ v8 0 t (P:nuclear fragmentation during apoptosissq ~ 0 t $P:negative regulation of endocytosissq ~ R 0 t ,P:induction of retinal programmed cell deathsq ~ [ 0 t P:nucleotide phosphorylationsq ~ < 0 t P:protein homooligomerizationsq ~ , 0 t +P:release of cytochrome c from mitochondriasq ~ 0 t P:B cell apoptosissq ~ 0 t 0P:nucleotide-excision repair, DNA damage removalsq ~ 0 t P:reproductionsq ~ ! 0 t 0P:induction of apoptosis via death domain rec...sq ~ 0 t .P:mitochondrial fragmentation during apoptosissq ~ 0 t )P:positive regulation of neuron apoptosissq ~ x 0 t 0P:cleavage of cytosolic proteins during apopt...sq ~ 0 t -P:release of matrix enzymes from mitochondriasq ~ 0 t .P:DNA damage response, detection of DNA damagesq ~ ʩ 0 t 0P:regulation of mitochondrial membrane potentialsq ~ 0 t (P:regulation of protein homodimerizationsq ~ 0 t *P:regulation of protein heterodimerizationsq ~ 0 t F:protein bindingsq ~ w 0 t F:caspase activitysq ~ ? 0 t F:kinase activitysq ~ M 0 t F:enzyme bindingsq ~ 2 0 t F:identical protein bindingsq ~ 0 t F:signal transducer activitysq ~ C 0 t (F:polynucleotide 3'-phosphatase activitysq ~ 0 t F:death receptor bindingsq ~ 0 t
F:ATP bindingsq ~ J 0 t F:protein kinase CK2 activitysq ~ D 0 t 0F:ATP-dependent polydeoxyribonucleotide 5'-hy...sq ~ 3 0 t #F:protein homodimerization activitysq ~ 0 t F:choline kinase activitysq ~ j 0 t F:double-stranded DNA bindingsq ~ 0 t %F:protein heterodimerization activitysq ~ } 0 t F:protein N-terminus bindingsq ~ d 0 t F:damaged DNA bindingsq ~ 0 t F:BH3 domain bindingsq ~ 0 t F:cytoskeletal protein bindingsq ~ K 0 t F:nucleotide kinase activitysq ~ a 0 t F:lipid bindingsq ~ 0 t F:endonuclease activitysq ~ 0 t C:nucleussq ~ 0 t C:plasma membranesq ~ i 0 t C:cytoplasmsq ~ k 0 t C:mitochondrionsq ~ } 0 t 0C:mitochondrial permeability transition pore ...sq ~ 0 t C:endoplasmic reticulum membranesq ~ 0 t C:cytosolsq ~ 0 t C:cytoskeletonsq ~ =
0 t C:actin cytoskeletonppppppppppxsq ~ uq ~
sq ~ 0 t P:anti-apoptosist 6916sq ~ 0 t P:RNA splicingt 8380sq ~ 0 t F:identical protein bindingt 42802sq ~ 0 t
F:RNA bindingt 3723sq ~ 0 t C:cytosolt 5829sq ~ 0 t C:nucleolust 5730ppppxsq ~ uq ~
sq ~ 0t IPR001315t CARDpppppppppxsq ~ uq ~
sq ~ 0t CARDt PF00619pppppppppxt O60936t
NOL3_HUMANsq ~ uq ~
sq ~ 0t Apoptosis repressor with CARDsq ~ 0t #Muscle-enriched cytoplasmic proteinsq ~ 0t Mypsq ~ 0t Nucleolar protein of 30 kDasq ~ 0t Nop30pppppxt Homo sapienst MCL1sq ~?=ڐO %t ;Induced myeloid leukemia cell differentiation protein Mcl-1sq ~ uq ~
sq ~ t ENSG00000143384pppppppppxsq ~ uq ~
sq ~ t MCL1pppppppppxsq ~ uuq ~
sq ~
t P:induction of apoptosissq ~ , t +P:release of cytochrome c from mitochondriasq ~ t P:anti-apoptosissq ~ t *P:regulation of protein heterodimerizationsq ~ t (P:regulation of protein homodimerizationsq ~ ! t 0P:negative regulation of survival gene produc...sq ~ t P:caspase activationsq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ ! t P:apoptotic programsq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ t )P:positive regulation of neuron apoptosissq ~ : t "P:negative regulation of apoptosissq ~ % t P:response to toxinsq ~ v8 t (P:nuclear fragmentation during apoptosissq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ t P:apoptosissq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ J t .P:regulation of progression through cell cyclesq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ t P:neuron apoptosissq ~ ! t %P:caspase activation via cytochrome csq ~ t %P:phosphoinositide-mediated signalingsq ~ t 0P:negative regulation of fibroblast prolifera...sq ~ ɗ t P:defense response to virussq ~ ʾ t 0P:negative regulation of mitochondrial depola...sq ~ C t P:response to dsRNAsq ~ ! t 0P:induction of apoptosis via death domain rec...sq ~ < t P:protein homooligomerizationsq ~ [ t P:cell proliferationsq ~ ' t P:response to X-raysq ~ u t P:mitochondrial fusionsq ~ t P:female pregnancysq ~ q t P:germ cell developmentsq ~ ! t !P:apoptotic mitochondrial changessq ~ $b t P:response to radiationsq ~ $ t P:response to UVsq ~ t .P:mitochondrial fragmentation during apoptosissq ~ 9 t "P:positive regulation of apoptosissq ~ f t P:negative regulation of growthsq ~ t 0P:Wnt receptor signaling pathway through beta...sq ~ t P:response to nicotinesq ~ t -P:release of matrix enzymes from mitochondriasq ~ P t .P:negative regulation of cellular pH reductionsq ~ w t P:leukocyte chemotaxissq ~ R t ,P:induction of retinal programmed cell deathsq ~ Gg t 0P:protein amino acid N-linked glycosylation v...sq ~ F t !P:peptidyl-serine phosphorylationsq ~ @ t P:histone ubiquitinationsq ~ t 0P:positive regulation of protein export from ...sq ~ '7 t P:response to iron ionsq ~ t P:regulation of apoptosissq ~ d t P:synaptic transmissionsq ~ t P:signal transductionsq ~ \ t %P:telomere maintenance via telomerasesq ~ t "P:cellular calcium ion homeostasissq ~ t P:anion transportsq ~ t P:calcium ion transportsq ~ l t
P:proteolysissq ~ t $P:DNA fragmentation during apoptosissq ~ t P:protein polyubiquitinationsq ~ t P:DNA repairsq ~ t P:B cell apoptosissq ~ t t P:DNA replicationsq ~ Y t P:glycogen metabolic processsq ~ 4 t 0P:protein insertion into mitochondrial membra...sq ~ t P:cellular iron ion homeostasissq ~ t -P:cell structure disassembly during apoptosissq ~ G t P:ER overload responsesq ~ 8 t P:cellular defense responsesq ~ / t P:humoral immune responsesq ~ & t P:response to stresssq ~ t P:chemotaxissq ~ t P:transformed cell apoptosissq ~ t P:virus-infected cell apoptosissq ~
t P:cleavage of laminsq ~ > t !P:response to DNA damage stimulussq ~ t F:protein bindingsq ~ t %F:protein heterodimerization activitysq ~ 3 t #F:protein homodimerization activitysq ~ 2 t F:identical protein bindingsq ~ t F:BH3 domain bindingsq ~ t #F:ubiquitin-protein ligase activitysq ~ X t %F:glycogen synthase kinase 3 activitysq ~ n t &F:NAD+ ADP-ribosyltransferase activitysq ~ c t F:MAP kinase activitysq ~ t F:protein dimerization activitysq ~ ] t
F:DNA bindingsq ~ t F:death receptor bindingsq ~ t F:receptor antagonist activitysq ~ Q t F:microtubule bindingsq ~ a t F:lipid bindingsq ~ t F:calcium ion bindingsq ~ s t F:NF-kappaB bindingsq ~ Y< t &F:voltage-gated anion channel activitysq ~ w t F:caspase activitysq ~ t F:protease bindingsq ~ ~ t F:MutLalpha complex bindingsq ~ t
F:p53 bindingsq ~ k t C:mitochondrionsq ~ m t C:mitochondrial outer membranesq ~ t C:cytosolsq ~ t C:membrane fractionsq ~ t C:nucleussq ~ @K t C:myosin complexsq ~ R t C:pore complexsq ~ t C:extracellular regionsq ~ : t $C:oligosaccharyl transferase complexsq ~
t C:chromosome, telomeric regionsq ~ t C:endoplasmic reticulum membranesq ~ t C:multivesicular bodysq ~ x t "C:beta-catenin destruction complexsq ~ | t C:nuclear membranesq ~ } t 0C:mitochondrial permeability transition pore ...sq ~ i t C:cytoplasmsq ~ t "C:DNA replication factor C complexsq ~ t C:extracellular spacesq ~ W t !C:perinuclear region of cytoplasmpppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t P:anti-apoptosist 6916sq ~ t P:apoptotic programt 8632sq ~ t P:cell fate determinationt 1709sq ~ t P:cellular homeostasist 19725sq ~ t &P:multicellular organismal developmentt 7275sq ~ t F:protein channel activityt 15266sq ~ t %F:protein heterodimerization activityt 46982sq ~ t C:mitochondrial outer membranet 5741ppxsq ~ uq ~
sq ~ t IPR013281t Apop_reg_Mc1sq ~ t IPR002475t
BCL2_apoptsissq ~ t IPR000712t Bcl2_BHpppppppxsq ~ uq ~
sq ~ t Bcl-2t PF00452pppppppppxt Q07820t
MCL1_HUMANsq ~ uq ~
sq ~ t Bcl-2-related protein EAT/mcl1sq ~ t mcl1/EATppppppppxt Homo sapienst B2LA1sq ~?__ .E %t Bcl-2-related protein A1sq ~ uq ~
sq ~ .Et ENSG00000140379pppppppppxsq ~ uq ~
sq ~ .E t BCL2A1sq ~ .E t BCL2L5sq ~ .E t BFL1sq ~ .E t GRSsq ~ .E t HBPA1pppppxsq ~ ;uq ~
Psq ~ .E t P:induction of apoptosissq ~ , .E t +P:release of cytochrome c from mitochondriasq ~ ! .E t 0P:negative regulation of survival gene produc...sq ~ .E t (P:regulation of protein homodimerizationsq ~ .E t P:apoptosissq ~ ! .E t 0P:induction of apoptosis by extracellular sig...sq ~ .E t P:caspase activationsq ~ ( .E t 0P:establishment and/or maintenance of transme...sq ~ ! .E t P:apoptotic programsq ~ .E t *P:regulation of protein heterodimerizationsq ~ ʩ .E t 0P:regulation of mitochondrial membrane potentialsq ~ .E t )P:positive regulation of neuron apoptosissq ~ ! .E t !P:apoptotic mitochondrial changessq ~ < .E t P:protein homooligomerizationsq ~ ! .E t %P:caspase activation via cytochrome csq ~ .E t P:neuron apoptosissq ~ 6 .E t 0P:regulation of mitochondrial membrane permea...sq ~ ! .E t 0P:induction of apoptosis by intracellular sig...sq ~ ! .E t 0P:induction of apoptosis via death domain rec...sq ~ % .E t P:response to toxinsq ~ c .E t P:cell-cell signalingsq ~ v8 .E t (P:nuclear fragmentation during apoptosissq ~ .E t -P:release of matrix enzymes from mitochondriasq ~ 9 .E t "P:positive regulation of apoptosissq ~ .E t P:B cell apoptosissq ~ R .E t ,P:induction of retinal programmed cell deathsq ~ f .E t P:negative regulation of growthsq ~ .E t .P:mitochondrial fragmentation during apoptosissq ~ C .E t P:response to dsRNAsq ~ .E t $P:DNA fragmentation during apoptosissq ~
.E t P:cleavage of laminsq ~ .E t P:virus-infected cell apoptosissq ~ .E t P:transformed cell apoptosissq ~ .E t 0P:epidermal growth factor receptor signaling ...sq ~ a .E t !P:Ras protein signal transductionsq ~ q .E t P:germ cell developmentsq ~ u .E t P:mitochondrial fusionsq ~ ^ .E t $P:insulin receptor signaling pathwaysq ~ .E t -P:cell structure disassembly during apoptosissq ~ .E t F:protein bindingsq ~ .E t %F:protein heterodimerization activitysq ~ .E t F:protein dimerization activitysq ~ " .E t *F:epidermal growth factor receptor bindingsq ~ .E t F:death receptor bindingsq ~ .E t F:BH3 domain bindingsq ~ ( .E t $F:insulin receptor substrate bindingsq ~ .E t F:SH3/SH2 adaptor activitysq ~ Q .E t F:microtubule bindingsq ~ 2 .E t F:identical protein bindingsq ~ a .E t F:lipid bindingsq ~ 3 .E t #F:protein homodimerization activitysq ~ k .E t C:mitochondrionsq ~ .E t C:cytosolsq ~ @K .E t C:myosin complexsq ~ R .E t C:pore complexsq ~ .E t C:membrane fractionsq ~ m .E t C:mitochondrial outer membranesq ~ } .E t 0C:mitochondrial permeability transition pore ...sq ~ .E t C:endoplasmic reticulum membranepppppppppppppppppppppxsq ~ uq ~
sq ~ .E t P:anti-apoptosist 6916sq ~ .E t F:protein bindingt 5515sq ~ .E t C:intracellulart 5622pppppppxsq ~ uq ~
sq ~ .Et IPR013282t Apop_reg_Bcl2Relsq ~ .Et IPR012238t
Bcl2_apop_regsq ~ .Et IPR002475t
BCL2_apoptsissq ~ .Et IPR000712t Bcl2_BHppppppxsq ~ uq ~
sq ~ .Et Bcl-2t PF00452pppppppppxt Q16548t B2LA1_HUMANsq ~ uq ~
sq ~ .Et
Protein BFL-1sq ~ .Et +Hemopoietic-specific early response proteinsq ~ .Et Protein GRSpppppppxt Homo sapienst VDAC1sq ~? J} t !P:response to DNA damage stimulussq ~ + J} t P:immune responsesq ~ J} t P:cell agingsq ~ * J} t P:inflammatory responsesq ~ & J} t P:response to stresssq ~ J} t "P:regulation of muscle contractionsq ~ J} t P:cell motilitysq ~ J} t P:transformed cell apoptosissq ~
J} t P:cleavage of laminsq ~ J} t P:nucleocytoplasmic transportsq ~ J} t !P:intracellular protein transportsq ~ l J} t
P:proteolysissq ~
J} t P:translational initiationsq ~ s J} t P:spermatogenesissq ~ % J} t P:response to woundingsq ~ >x J} t P:proton transportsq ~ J} t P:centrosome cyclesq ~ ƶ J} t *P:positive regulation of T cell activationsq ~ F J} t P:actin filament severingsq ~ H J} t #P:barbed-end actin filament cappingsq ~ I J} t !P:actin filament bundle formationsq ~ ǔ J} t .P:activation of NF-kappaB transcription factorsq ~ J} t P:nuclear importsq ~
J} t 0P:positive regulation of T cell cytokine prod...sq ~ 6 J} t "P:B cell homeostatic proliferationsq ~ 4 J} t 0P:protein insertion into mitochondrial membra...sq ~ J} t P:B cell apoptosissq ~ J} t "P:T cell homeostatic proliferationsq ~ J} t P:cell fate determinationsq ~ J} t (P:nuclear mRNA splicing, via spliceosomesq ~ J} t )P:nuclear mRNA 3'-splice site recognitionsq ~ J} t P:protein polyubiquitinationsq ~ Ƥ J} t #P:T cell receptor signaling pathwaysq ~ J} t 0P:negative regulation of fibroblast prolifera...sq ~ J} t %P:vesicle transport along microtubulesq ~ M
J} t P:cellular homeostasissq ~ uY J} t P:actin filament polymerizationsq ~ u J} t P:protein catabolic processsq ~ J} t -P:release of matrix enzymes from mitochondriasq ~ J} t P:ribosome assemblysq ~ k J} t P:Sertoli cell proliferationsq ~ J} t P:peptide catabolic processsq ~ J} t )P:negative regulation of neuron apoptosissq ~ J} t )P:positive regulation of neuron apoptosissq ~ J} t .P:mitochondrial fragmentation during apoptosissq ~ J} t P:cellular respirationsq ~ J} t P:bone resorptionsq ~ & J} t $P:positive regulation of proteolysissq ~ J J} t $P:retinal cell programmed cell deathsq ~ R J} t ,P:induction of retinal programmed cell deathsq ~ J J} t .P:regulation of progression through cell cyclesq ~ J} t F:protein bindingsq ~ J} t %F:protein heterodimerization activitysq ~ NJ J} t F:unfolded protein bindingsq ~ J} t F:BH3 domain bindingsq ~ J} t
F:ATP bindingsq ~ J} t F:receptor activitysq ~ J} t F:signal transducer activitysq ~ 3 J} t #F:protein homodimerization activitysq ~ 2 J} t F:identical protein bindingsq ~ J} t
F:RNA bindingsq ~ J} t $F:structural constituent of ribosomesq ~ @ J} t F:protein kinase activitysq ~ B J} t *F:protein serine/threonine kinase activitysq ~ Y J} t F:protein kinase C activitysq ~ ` J} t $F:NF-kappaB-inducing kinase activitysq ~ J} t #F:ubiquitin-protein ligase activitysq ~ J} t $F:transcription coactivator activitysq ~ J} t F:calcium ion bindingsq ~ q J} t F:single-stranded DNA bindingsq ~ c J} t 0F:electron transporter, transferring electron...sq ~ , J} t F:hexokinase activitysq ~
J} t 0F:glyceraldehyde-3-phosphate dehydrogenase (p...sq ~ J} t F:microtubule motor activitysq ~ J} t F:actin bindingsq ~ J} t F:creatine kinase activitysq ~ { J} t F:GABA receptor bindingsq ~ J} t F:CARD domain bindingsq ~ g J} t F:beta-tubulin bindingsq ~ J} t F:single-stranded RNA bindingsq ~ s J} t F:NF-kappaB bindingsq ~ Q J} t F:aminopeptidase activitysq ~ J} t %F:carbonyl reductase (NADPH) activitysq ~ O J} t F:endopeptidase activitysq ~ J} t C:integral to membranesq ~ J} t "C:muscle thin filament tropomyosinsq ~ J} t C:kinesin complexsq ~ J} t
C:nucleoplasmsq ~ J} t %C:protein phosphatase type 2A complexsq ~ J} t C:endoplasmic reticulum membranesq ~ J} t
C:lysosomesq ~ R J} t C:pore complexsq ~ @W J} t 0C:vacuolar proton-transporting V-type ATPase ...sq ~ J} t C:intracellularsq ~ J} t C:centrosomesq ~ J} t C:cytosolic partsq ~ b J} t C:nucleolussq ~ ' J} t C:cell surfacesq ~ } J} t 0C:mitochondrial permeability transition pore ...sq ~ ~ J} t #C:mitochondrial intermembrane spacesq ~ W J} t !C:perinuclear region of cytoplasmpppxsq ~ uq ~
sq ~ J} t P:anion transportt 6820sq ~ J} t P:apoptotic programt 8632sq ~ J} t F:protein bindingt 5515sq ~ J} t &F:voltage-gated anion channel activityt 22844sq ~ J} t C:mitochondrial outer membranet 5741sq ~ J} t C:pore complext 46930ppppxsq ~ uq ~
sq ~ J}t IPR001925t Porin_Eukpppppppppxsq ~ uq ~
sq ~ J}t Porin_3t PF01459pppppppppxt P21796t VDAC1_HUMANsq ~ uq ~
sq ~ J}t VDAC-1sq ~ J}t hVDAC1sq ~ J}t ,Outer mitochondrial membrane protein porin 1sq ~ J}t Plasmalemmal porinsq ~ J}t
Porin 31HLsq ~ J}t
Porin 31HMppppxt Homo sapienst APRsq ~?ə 03 %t 1Phorbol-12-myristate-13-acetate-induced protein 1sq ~ uq ~
sq ~ 03t ENSG00000141682pppppppppxsq ~ uq ~
sq ~ 03 t PMAIP1pppppppppxsq ~ Cuq ~
Psq ~ 03 t P:anti-apoptosissq ~ ! 03 t 0P:negative regulation of survival gene produc...sq ~ , 03 t +P:release of cytochrome c from mitochondriasq ~ 03 t (P:regulation of protein homodimerizationsq ~ 03 t *P:regulation of protein heterodimerizationsq ~ % 03 t P:response to toxinsq ~ ʩ 03 t 0P:regulation of mitochondrial membrane potentialsq ~ 6 03 t 0P:regulation of mitochondrial membrane permea...sq ~ ! 03 t 0P:induction of apoptosis by extracellular sig...sq ~ v8 03 t (P:nuclear fragmentation during apoptosissq ~ M
03 t P:cellular homeostasissq ~ = 03 t P:glucose transportsq ~ ! 03 t %P:caspase activation via cytochrome csq ~ ( 03 t 0P:establishment and/or maintenance of transme...sq ~ '7 03 t P:response to iron ionsq ~ $b 03 t P:response to radiationsq ~ ! 03 t !P:apoptotic mitochondrial changessq ~ P 03 t .P:negative regulation of cellular pH reductionsq ~ ɗ 03 t P:defense response to virussq ~ 03 t P:neuron apoptosissq ~ < 03 t P:protein homooligomerizationsq ~ R 03 t ,P:induction of retinal programmed cell deathsq ~ D 03 t 0P:negative regulation of transcription, DNA-d...sq ~ F 03 t 0P:negative regulation of myeloid cell differe...sq ~ 03 t .P:mitochondrial fragmentation during apoptosissq ~ 03 t )P:positive regulation of neuron apoptosissq ~ ʾ 03 t 0P:negative regulation of mitochondrial depola...sq ~ 03 t P:response to nicotinesq ~ 03 t -P:release of matrix enzymes from mitochondriasq ~ ! 03 t P:apoptotic programsq ~ ! 03 t 0P:induction of apoptosis by intracellular sig...sq ~ J 03 t .P:regulation of progression through cell cyclesq ~ 03 t P:cell fate determinationsq ~ 03 t P:B cell apoptosissq ~ 03 t P:mesonephros developmentsq ~ 03 t P:apoptosissq ~ 03 t $P:DNA fragmentation during apoptosissq ~
03 t P:cleavage of laminsq ~ 03 t P:transformed cell apoptosissq ~ / 03 t P:humoral immune responsesq ~ s 03 t P:spermatogenesissq ~ q 03 t P:germ cell developmentsq ~ u 03 t P:mitochondrial fusionsq ~ 03 t P:female pregnancysq ~ k 03 t &P:multicellular organismal developmentsq ~ 03 t $P:central nervous system developmentsq ~ 03 t F:protein bindingsq ~ 03 t %F:protein heterodimerization activitysq ~ 3 03 t #F:protein homodimerization activitysq ~ 03 t F:BH3 domain bindingsq ~ a 03 t F:lipid bindingsq ~ 03 t F:protease bindingsq ~ ] 03 t
F:DNA bindingsq ~ 03 t ,F:glucose transmembrane transporter activitysq ~ @ 03 t -F:specific transcriptional repressor activitysq ~ 2 03 t F:identical protein bindingsq ~ ; 03 t F:protein channel activitysq ~ m 03 t C:mitochondrial outer membranesq ~ @ 03 t
C:PML bodysq ~ @ 03 t C:nuclear specksq ~ B 03 t #C:transcriptional repressor complexsq ~ | 03 t C:nuclear membranesq ~ 03 t C:cytosolsq ~ 03 t C:endoplasmic reticulum membranesq ~ } 03 t 0C:mitochondrial permeability transition pore ...sq ~ i 03 t C:cytoplasmsq ~ 03 t C:intracellularpppppppppppppxsq ~ uq ~
sq ~ 03 t P:caspase activationt 6919sq ~ 03 t -P:cell structure disassembly during apoptosist 6921sq ~ 03 t P:induction of apoptosist 6917sq ~ 03 t +P:release of cytochrome c from mitochondriat 1836sq ~ 03 t P:response to dsRNAt 43331sq ~ 03 t P:virus-infected cell apoptosist 6926sq ~ 03 t F:protein bindingt 5515sq ~ 03 t C:mitochondriont 5739ppxppt Q13794t APR_HUMANsq ~ uq ~
sq ~ 03t PMA-induced protein 1sq ~ 03t $Immediate-early-response protein APRppppppppxt Homo sapienst BAXCsq ~?--
t
%t &BAX protein, cytoplasmic isoform gammasq ~ uq ~
sq ~ tt ENSG00000087088pppppppppxsq ~ uq ~
sq ~ t t BAXpppppppppxsq ~ 5uq ~
Psq ~ , t t +P:release of cytochrome c from mitochondriasq ~ t t P:anti-apoptosissq ~ 6 t t 0P:regulation of mitochondrial membrane permea...sq ~ t t P:caspase activationsq ~ ʩ t t 0P:regulation of mitochondrial membrane potentialsq ~ t t *P:regulation of protein heterodimerizationsq ~ t t (P:regulation of protein homodimerizationsq ~ t t P:induction of apoptosissq ~ ! t t P:apoptotic programsq ~ t t -P:cell structure disassembly during apoptosissq ~ ( t t 0P:establishment and/or maintenance of transme...sq ~ % t t P:response to toxinsq ~ | t t P:female gamete generationsq ~ v6 t t P:apoptotic nuclear changessq ~ t t P:female pregnancysq ~ t t P:response to nicotinesq ~ M
t t P:cellular homeostasissq ~ ʾ t t 0P:negative regulation of mitochondrial depola...sq ~ C t t P:response to dsRNAsq ~ ! t t 0P:negative regulation of survival gene produc...sq ~ $b t t P:response to radiationsq ~ '7 t t P:response to iron ionsq ~ s t t P:spermatogenesissq ~ k t t &P:multicellular organismal developmentsq ~ J t t .P:regulation of progression through cell cyclesq ~ t t P:cell fate determinationsq ~ t t P:virus-infected cell apoptosissq ~ ɗ t t P:defense response to virussq ~ t t P:neuron apoptosissq ~ t t 0P:generation of precursor metabolites and energysq ~ t t P:transportsq ~ t t P:anion transportsq ~ t t "P:mitochondrial genome maintenancesq ~ / t t P:humoral immune responsesq ~ P t t .P:negative regulation of cellular pH reductionsq ~ t t F:protein bindingsq ~ t t %F:protein heterodimerization activitysq ~ 3 t t #F:protein homodimerization activitysq ~ 2 t t F:identical protein bindingsq ~ Y< t t &F:voltage-gated anion channel activitysq ~ ; t t F:protein channel activitysq ~ ;g t t ,F:adenine transmembrane transporter activitysq ~ t t F:protease bindingsq ~ t t F:BH3 domain bindingsq ~ k t t C:mitochondrionsq ~ m t t C:mitochondrial outer membranesq ~ R t t C:pore complexsq ~ i t t C:cytoplasmsq ~ t t C:intracellularsq ~ t t C:cytosolsq ~ t t C:membrane fractionsq ~ t t C:integral to plasma membranesq ~ | t t C:nuclear membranepppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t t !P:apoptotic mitochondrial changest 8637sq ~ t t P:germ cell developmentt 7281sq ~ t t 0P:induction of apoptosis by extracellular sig...t 8624sq ~ t t 0P:negative regulation of survival gene produc...t 8634sq ~ t t F:protein bindingt 5515pppppxppt Q07815t
BAXC_HUMANpt Homo sapienst MOAP1sq ~?t]Eg L
%t Modulator of apoptosis 1sq ~ uq ~
sq ~ Lt ENSG00000165943pppppppppxsq ~ uq ~
sq ~ L t MOAP1sq ~ L t PNMA4ppppppppxsq ~ Euq ~
Psq ~ , L t +P:release of cytochrome c from mitochondriasq ~ ! L t 0P:negative regulation of survival gene produc...sq ~ ! L t 0P:induction of apoptosis by extracellular sig...sq ~ L t *P:regulation of protein heterodimerizationsq ~ L t (P:regulation of protein homodimerizationsq ~ 6 L t 0P:regulation of mitochondrial membrane permea...sq ~ ʩ L t 0P:regulation of mitochondrial membrane potentialsq ~ % L t P:response to toxinsq ~ ( L t 0P:establishment and/or maintenance of transme...sq ~ K L t 0P:cytokine and chemokine mediated signaling p...sq ~ '7 L t P:response to iron ionsq ~ $b L t P:response to radiationsq ~ ! L t !P:apoptotic mitochondrial changessq ~ ! L t %P:caspase activation via cytochrome csq ~ q L t P:germ cell developmentsq ~ ! L t 0P:induction of apoptosis by intracellular sig...sq ~ ! L t 0P:induction of apoptosis via death domain rec...sq ~ v8 L t (P:nuclear fragmentation during apoptosissq ~ P L t .P:negative regulation of cellular pH reductionsq ~ ɗ L t P:defense response to virussq ~ L t P:neuron apoptosissq ~ < L t P:protein homooligomerizationsq ~ ) L t .P:positive regulation of inflammatory responsesq ~ s L t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ R L t ,P:induction of retinal programmed cell deathsq ~ x L t 0P:positive regulation of transcription from R...sq ~ L t .P:mitochondrial fragmentation during apoptosissq ~ L t )P:positive regulation of neuron apoptosissq ~ L t P:response to nicotinesq ~ L t -P:release of matrix enzymes from mitochondriasq ~ ʾ L t 0P:negative regulation of mitochondrial depola...sq ~ J L t .P:regulation of progression through cell cyclesq ~ % L t !P:prostaglandin metabolic processsq ~ L t P:caspase activationsq ~
L t P:cleavage of laminsq ~ L t $P:DNA fragmentation during apoptosissq ~ L t P:transformed cell apoptosissq ~ / L t P:humoral immune responsesq ~ L t P:cell cycle arrestsq ~ L t P:signal transductionsq ~ L t P:apoptosissq ~ R L t )P:activation of NF-kappaB-inducing kinasesq ~ a L t !P:Ras protein signal transductionsq ~ L t P:female pregnancysq ~ u L t P:mitochondrial fusionsq ~ L t P:B cell apoptosissq ~ L t P:anti-apoptosissq ~ 2 L t F:identical protein bindingsq ~ L t %F:protein heterodimerization activitysq ~ 3 L t #F:protein homodimerization activitysq ~ L t F:BH3 domain bindingsq ~ L t F:protein bindingsq ~ a L t F:lipid bindingsq ~ L t F:TRAIL bindingsq ~ L t F:death receptor activitysq ~ L t )F:tumor necrosis factor receptor activitysq ~ L t F:protease bindingsq ~ N L t F:zinc ion bindingsq ~ ! L t F:caspase activator activitysq ~ m L t C:mitochondrial outer membranesq ~ L t C:nucleussq ~ L t C:cytosolsq ~ L t C:endoplasmic reticulum membranesq ~ } L t 0C:mitochondrial permeability transition pore ...sq ~ L t C:extracellular regionsq ~ = L t C:microtubule cytoskeletonsq ~ > L t C:integral to membranesq ~ | L t C:nuclear membranesq ~ L t C:integral to plasma membranepppppppppppxsq ~ uq ~
sq ~ L t P:apoptotic nuclear changest 30262sq ~ L t P:caspase activationt 6919sq ~ L t -P:cell structure disassembly during apoptosist 6921sq ~ L t #F:protein homodimerization activityt 42803sq ~ L t C:cytoplasmt 5737pppppxppt Q96BY2t MOAP1_HUMANsq ~ uq ~
sq ~ Lt MAP-1sq ~ Lt MAP1sq ~ Lt Paraneoplastic antigen Ma4pppppppxt Homo sapienst BAXBsq ~?GG %t 1Apoptosis regulator BAX, cytoplasmic isoform betasq ~ uq ~
sq ~ t ENSG00000087088pppppppppxsq ~ uq ~
sq ~ t BAXpppppppppxsq ~ Nuq ~
Psq ~ t P:anti-apoptosissq ~ , t +P:release of cytochrome c from mitochondriasq ~ t P:caspase activationsq ~ t P:induction of apoptosissq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ ! t P:apoptotic programsq ~ t -P:cell structure disassembly during apoptosissq ~ t (P:regulation of protein homodimerizationsq ~ t *P:regulation of protein heterodimerizationsq ~ t P:neuron apoptosissq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ J t .P:regulation of progression through cell cyclesq ~ ! t 0P:DNA damage response, signal transduction re...sq ~ ! t 0P:induction of apoptosis via death domain rec...sq ~ t P:RNA splicingsq ~ [ t P:cell proliferationsq ~ t P:female pregnancysq ~ | t P:female gamete generationsq ~ k t &P:multicellular organismal developmentsq ~ s t P:spermatogenesissq ~ ʾ t 0P:negative regulation of mitochondrial depola...sq ~ ! t 0P:negative regulation of survival gene produc...sq ~ ɗ t P:defense response to virussq ~ f t P:negative regulation of growthsq ~ C t P:response to dsRNAsq ~ t )P:negative regulation of caspase activitysq ~ t P:response to nicotinesq ~ w t P:leukocyte chemotaxissq ~ v6 t P:apoptotic nuclear changessq ~ M
t P:cellular homeostasissq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ '7 t P:response to iron ionsq ~ % t P:response to toxinsq ~ $b t P:response to radiationsq ~ t P:cell cycle arrestsq ~ K t 0P:unfolded protein response, activation of si...sq ~ P t .P:negative regulation of cellular pH reductionsq ~ t P:cell fate determinationsq ~ t 0P:generation of precursor metabolites and energysq ~ D t $P:protein amino acid phosphorylationsq ~ E t 0P:negative regulation of protein kinase activitysq ~ t P:transportsq ~ / t P:humoral immune responsesq ~ t P:virus-infected cell apoptosissq ~ t P:cellular iron ion homeostasissq ~ t P:anion transportsq ~ t "P:mitochondrial genome maintenancesq ~ t F:protein bindingsq ~ 3 t #F:protein homodimerization activitysq ~ t %F:protein heterodimerization activitysq ~ 2 t F:identical protein bindingsq ~ B t *F:protein serine/threonine kinase activitysq ~ t F:endoribonuclease activitysq ~ t F:death receptor bindingsq ~ t F:receptor antagonist activitysq ~ t
F:RNA bindingsq ~ t F:protease bindingsq ~ t F:BH3 domain bindingsq ~ t F:magnesium ion bindingsq ~ t
F:ATP bindingsq ~ t %F:protein kinase C inhibitor activitysq ~ ; t F:protein channel activitysq ~ ;g t ,F:adenine transmembrane transporter activitysq ~ Y< t &F:voltage-gated anion channel activitysq ~ k t C:mitochondrionsq ~ m t C:mitochondrial outer membranesq ~ i t C:cytoplasmsq ~ t C:cytosolsq ~ t C:membrane fractionsq ~ R t C:pore complexsq ~ t C:integral to plasma membranesq ~ b t C:nucleolussq ~ t C:extracellular regionsq ~ u t ,C:integral to endoplasmic reticulum membranesq ~ t C:extracellular spacesq ~ | t C:nuclear membranesq ~ t C:intracellularsq ~ W t !C:perinuclear region of cytoplasmppxsq ~ uq ~
(sq ~ t P:transformed cell apoptosist 6927sq ~ t .P:mitochondrial fragmentation during apoptosist 43653sq ~ t P:mitochondrial fusiont 8053sq ~ t 0P:negative regulation of survival gene produc...t 8634sq ~ t (P:nuclear fragmentation during apoptosist 30264sq ~ t )P:positive regulation of neuron apoptosist 43525sq ~ t P:protein homooligomerizationt 51260sq ~ t 0P:regulation of mitochondrial membrane potentialt 51881sq ~ t *P:regulation of protein heterodimerizationt 43497sq ~ t (P:regulation of protein homodimerizationt 43496sq ~ t +P:release of cytochrome c from mitochondriat 1836sq ~ t -P:release of matrix enzymes from mitochondriat 32976sq ~ t P:response to toxint 9636sq ~ t ,P:induction of retinal programmed cell deatht 46674sq ~ t 0P:induction of apoptosis by intracellular sig...t 8629sq ~ t 0P:induction of apoptosis by extracellular sig...t 8624sq ~ t 0P:establishment and/or maintenance of transme...t 10248sq ~ t $P:DNA fragmentation during apoptosist 6309sq ~ t P:cleavage of lamint 6922sq ~ t %P:caspase activation via cytochrome ct 8635sq ~ t P:B cell apoptosist 1783sq ~ t F:BH3 domain bindingt 51434sq ~ t F:lipid bindingt 8289sq ~ t %F:protein heterodimerization activityt 46982sq ~ t #F:protein homodimerization activityt 42803sq ~ t 0C:mitochondrial permeability transition pore ...t 5757sq ~ t C:endoplasmic reticulum membranet 5789sq ~ t C:cytosolt 5829ppppppppppppxsq ~ uq ~
sq ~ t IPR012238t
Bcl2_apop_regsq ~ t IPR002475t
BCL2_apoptsissq ~ t IPR000712t Bcl2_BHpppppppxsq ~ uq ~
sq ~ t Bcl-2t PF00452pppppppppxt Q07814t
BAXB_HUMANpt Homo sapienst BAXAsq ~?ӱ;;
I %t /Apoptosis regulator BAX, membrane isoform alphasq ~ uq ~
sq ~ It ENSG00000087088pppppppppxsq ~ uq ~
sq ~ I t BAXpppppppppxsq ~ 5uq ~
Psq ~ I t P:anti-apoptosissq ~ , I t +P:release of cytochrome c from mitochondriasq ~ 6 I t 0P:regulation of mitochondrial membrane permea...sq ~ J I t .P:regulation of progression through cell cyclesq ~ I t P:induction of apoptosissq ~ I t (P:regulation of protein homodimerizationsq ~ I t *P:regulation of protein heterodimerizationsq ~ ʩ I t 0P:regulation of mitochondrial membrane potentialsq ~ ! I t P:apoptotic programsq ~ ! I t 0P:negative regulation of survival gene produc...sq ~ $b I t P:response to radiationsq ~ % I t P:response to toxinsq ~ ! I t 0P:DNA damage response, signal transduction re...sq ~ '7 I t P:response to iron ionsq ~ ( I t 0P:establishment and/or maintenance of transme...sq ~ M
I t P:cellular homeostasissq ~ w I t P:leukocyte chemotaxissq ~ P I t .P:negative regulation of cellular pH reductionsq ~ I t P:response to nicotinesq ~ I t )P:negative regulation of caspase activitysq ~ I t P:neuron apoptosissq ~ ɗ I t P:defense response to virussq ~ [ I t P:cell proliferationsq ~ I t P:female pregnancysq ~ ʾ I t 0P:negative regulation of mitochondrial depola...sq ~ E I t 0P:negative regulation of protein kinase activitysq ~ I t P:cellular iron ion homeostasissq ~ I t P:caspase activationsq ~ / I t P:humoral immune responsesq ~ k I t &P:multicellular organismal developmentsq ~ s I t P:spermatogenesissq ~ | I t P:female gamete generationsq ~ I t P:cell fate determinationsq ~ I t F:protein bindingsq ~ I t %F:protein heterodimerization activitysq ~ 3 I t #F:protein homodimerization activitysq ~ 2 I t F:identical protein bindingsq ~ I t F:receptor antagonist activitysq ~ I t %F:protein kinase C inhibitor activitysq ~ I t F:protease bindingsq ~ I t F:BH3 domain bindingsq ~ I t
F:GTP bindingsq ~ ; I t F:protein channel activitysq ~ m I t C:mitochondrial outer membranesq ~ k I t C:mitochondrionsq ~ i I t C:cytoplasmsq ~ I t C:membrane fractionsq ~ I t C:extracellular regionsq ~ W I t !C:perinuclear region of cytoplasmsq ~ R I t C:pore complexsq ~ I t C:extracellular spacesq ~ | I t C:nuclear membranesq ~ I t C:cytosolpppppppppppppppppppppppppppxsq ~ uq ~
sq ~ I t P:caspase activationt 6919sq ~ I t P:induction of apoptosist 6917sq ~ I t )P:positive regulation of neuron apoptosist 43525sq ~ I t *P:regulation of protein heterodimerizationt 43497sq ~ I t (P:regulation of protein homodimerizationt 43496sq ~ I t %F:protein heterodimerization activityt 46982sq ~ I t #F:protein homodimerization activityt 42803sq ~ I t C:cytosolt 5829sq ~ I t C:mitochondriont 5739pxsq ~ uq ~
sq ~ It IPR012238t
Bcl2_apop_regsq ~ It IPR002475t
BCL2_apoptsissq ~ It IPR000712t Bcl2_BHpppppppxsq ~ uq ~
sq ~ It Bcl-2t PF00452pppppppppxt Q07812t
BAXA_HUMANpt Homo sapienst BCLXsq ~? I J %t Apoptosis regulator Bcl-Xsq ~ uq ~
sq ~ t ENSG00000171552pppppppppxsq ~ uq ~
sq ~ t BCL2L1sq ~ t BCL2Lsq ~ t BCLXpppppppxsq ~ uq ~
@sq ~ t P:induction of apoptosissq ~
t P:anti-apoptosissq ~ t P:caspase activationsq ~ , t +P:release of cytochrome c from mitochondriasq ~ ! t %P:caspase activation via cytochrome csq ~ ! t P:apoptotic programsq ~ ! t 0P:negative regulation of survival gene produc...sq ~ t *P:regulation of protein heterodimerizationsq ~ t (P:regulation of protein homodimerizationsq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ t P:neuron apoptosissq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ t )P:positive regulation of neuron apoptosissq ~ t 0P:DNA damage response, signal transduction by...sq ~ 9 t "P:positive regulation of apoptosissq ~ ɗ t P:defense response to virussq ~ t $P:DNA fragmentation during apoptosissq ~ t P:apoptosissq ~ l t
P:proteolysissq ~ % t P:response to toxinsq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ t $P:central nervous system developmentsq ~ @e t P:protein processingsq ~ ~ t 0P:negative regulation of intracellular transportsq ~ vd t $P:negative regulation of cell growthsq ~ t P:cell agingsq ~ Y t 0P:chromosome organization and biogenesis (sen...sq ~ $ t P:response to UVsq ~ $b t P:response to radiationsq ~ 4 t P:Notch receptor processingsq ~ t P:nucleotide-excision repairsq ~ t P:chromosome segregationsq ~ k t &P:multicellular organismal developmentsq ~ m t )P:membrane protein ectodomain proteolysissq ~ 9 t P:protein foldingsq ~ t P:signal transductionsq ~ t -P:cell structure disassembly during apoptosissq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ M t (P:positive regulation of enzyme activitysq ~ t P:regulation of caspase activitysq ~ : t "P:negative regulation of apoptosissq ~ t -P:amyloid precursor protein catabolic processsq ~ J t .P:regulation of progression through cell cyclesq ~ f t P:negative regulation of growthsq ~ x t 0P:positive regulation of transcription from R...sq ~ R t ,P:induction of retinal programmed cell deathsq ~ t (P:negative regulation of DNA replicationsq ~ Z t P:JUN phosphorylationsq ~
t +P:negative regulation of membrane potentialsq ~ t 'P:positive regulation of anti-apoptosissq ~ [ t P:cell proliferationsq ~ \ t +P:positive regulation of cell proliferationsq ~ ^ t $P:insulin receptor signaling pathwaysq ~ t /P:positive regulation of T cell differentiationsq ~ t P:protein localizationsq ~ u t P:mitochondrial fusionsq ~ > t P:protein tetramerizationsq ~ q t P:germ cell developmentsq ~ < t P:protein homooligomerizationsq ~ Ǚ t *P:negative regulation of helicase activitysq ~ s t P:spermatogenesissq ~ | t P:female gamete generationsq ~ t P:nervous system developmentsq ~ t 0P:positive regulation of interleukin-1 beta s...sq ~ t 0P:negative regulation of neuroblast prolifera...sq ~ t 0P:negative regulation of fibroblast prolifera...sq ~ J t P:mesoderm developmentsq ~ t P:female pregnancysq ~ t 0P:insulin-like growth factor receptor signali...sq ~ t P:visual perceptionsq ~ t P:visual behaviorsq ~ t /P:positive regulation of B cell differentiationsq ~ t P:cellular respirationsq ~ t .P:mitochondrial fragmentation during apoptosissq ~ K t 0P:cytokine and chemokine mediated signaling p...sq ~ M
t P:cellular homeostasissq ~ N t 'P:negative regulation of anti-apoptosissq ~ uT t 0P:actin cytoskeleton organization and biogenesissq ~ u t P:neuron differentiationsq ~ v6 t P:apoptotic nuclear changessq ~ v8 t (P:nuclear fragmentation during apoptosissq ~ t )P:cellular response to glucose starvationsq ~ w5 t 'P:negative regulation of axon extensionsq ~ w t P:leukocyte chemotaxissq ~ t P:response to nicotinesq ~ {S t P:G1 DNA damage checkpointsq ~ t -P:release of matrix enzymes from mitochondriasq ~ U t P:regulation of phosphorylationsq ~ a t P:glucose homeostasissq ~ ! t 0P:induction of apoptosis via death domain rec...sq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ ! t 0P:DNA damage response, signal transduction re...sq ~ t )P:negative regulation of neuron apoptosissq ~ C t P:response to dsRNAsq ~ F t #P:peptidyl-tyrosine phosphorylationsq ~ ! t !P:apoptotic mitochondrial changessq ~ '7 t P:response to iron ionsq ~ ' t P:response to X-raysq ~ t P:regulation of apoptosissq ~ (\ t P:response to gamma radiationsq ~ ? t 'P:endoplasmic reticulum membrane fusionsq ~ @a t &P:negative regulation of transcriptionsq ~ P t .P:negative regulation of cellular pH reductionsq ~ ʾ t 0P:negative regulation of mitochondrial depola...sq ~ t P:anion transportsq ~ t 0P:oxygen and reactive oxygen species metaboli...sq ~ M t P:DNA damage checkpointsq ~ s t 0P:S-phase-specific transcription in mitotic c...sq ~ F t &P:protein amino acid dephosphorylationsq ~ t 0P:regulation of transcription from RNA polyme...sq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t P:chromatin remodelingsq ~ t P:mismatch repairsq ~ t P:base-excision repairsq ~ t P:DNA repairsq ~ w t P:glucose catabolic processsq ~ v t P:glucose metabolic processsq ~ t P:response to hypoxiasq ~ t P:in utero embryonic developmentsq ~ t P:cell fate determinationsq ~ t P:B cell apoptosissq ~ t P:cellular iron ion homeostasissq ~ J t !P:intracellular signaling cascadesq ~ t 0P:transmembrane receptor protein tyrosine kin...sq ~ t 0P:cell surface receptor linked signal transdu...sq ~ u t 0P:endoplasmic reticulum organization and biog...sq ~ t P:cell cycle arrestsq ~ j t P:microtubule-based movementsq ~ G t P:ER overload responsesq ~ 8 t P:cellular defense responsesq ~ / t P:humoral immune responsesq ~ & t P:response to stresssq ~
t P:cleavage of laminsq ~ t P:virus-infected cell apoptosissq ~ t P:transformed cell apoptosissq ~ + t P:immune responsesq ~ L t P:DNA replication checkpointsq ~ t P:muscle contractionsq ~ t P:cell motilitysq ~ < t ,P:protein import into nucleus, translocationsq ~ ' t F:protein bindingsq ~ t %F:protein heterodimerization activitysq ~ 3 t #F:protein homodimerization activitysq ~ t F:signal transducer activitysq ~ t
F:ATP bindingsq ~ ! t F:caspase activator activitysq ~ t F:BH3 domain bindingsq ~ t t F:transcription factor activitysq ~ w t F:caspase activitysq ~ ] t
F:DNA bindingsq ~ 2 t F:identical protein bindingsq ~ t F:DNA strand annealing activitysq ~ t F:copper ion bindingsq ~ M t F:enzyme bindingsq ~ t F:receptor bindingsq ~ t 0F:transmembrane receptor protein tyrosine kin...sq ~ t %F:receptor signaling protein activitysq ~ & t F:insulin receptor bindingsq ~ J t F:histone deacetylase bindingsq ~ t
F:GTP bindingsq ~ 7 t F:CD27 receptor bindingsq ~ t F:lamin bindingsq ~ ' t -F:insulin-like growth factor receptor bindingsq ~ i t "F:protein-tyrosine kinase activitysq ~ t %F:protein phosphatase type 1 activitysq ~ t F:nucleotide bindingsq ~ t F:magnesium ion bindingsq ~ t F:receptor antagonist activitysq ~ } t F:protein N-terminus bindingsq ~ R t F:viral receptor activitysq ~ t F:protease bindingsq ~ c t 0F:electron transporter, transferring electron...sq ~ t F:microtubule motor activitysq ~ t #F:phosphoinositide 3-kinase bindingsq ~ t F:death receptor bindingsq ~ O t F:endopeptidase activitysq ~ t F:nuclease activitysq ~ a t F:JUN kinase activitysq ~ t F:BH1 domain bindingsq ~ t F:SH2 domain bindingsq ~ a t F:lipid bindingsq ~ u t F:manganese ion bindingsq ~ Y< t &F:voltage-gated anion channel activitysq ~ NE t F:heme bindingsq ~ M t F:protein kinase bindingsq ~ B t F:SH3 domain bindingsq ~ @ t "F:transcription repressor activitysq ~ ; t F:protein channel activitysq ~ t F:3'-5' exonuclease activitysq ~ N t F:zinc ion bindingsq ~ o t F:enzyme activator activitysq ~ }Z t F:Pyrin domain bindingsq ~ Q t F:microtubule bindingsq ~ V t F:protein C-terminus bindingsq ~ k t C:mitochondrionsq ~ t C:cytosolsq ~ i t C:cytoplasmsq ~ t C:nucleussq ~ t C:membrane fractionsq ~ t C:endoplasmic reticulumsq ~ m t C:mitochondrial outer membranesq ~ t C:nuclear envelopesq ~ t C:integral to plasma membranesq ~ u t ,C:integral to endoplasmic reticulum membranesq ~ b t C:nucleolussq ~ R t C:pore complexsq ~ t C:intracellularsq ~ t
C:kinetochoresq ~ W t !C:perinuclear region of cytoplasmsq ~ @K t C:myosin complexsq ~ t C:Golgi apparatussq ~ t C:insoluble fractionsq ~ t
C:nucleoplasmsq ~ t $C:integral to nuclear inner membranesq ~ y t C:intrinsic to membranesq ~ t C:cytoplasmic dynein complexsq ~ t C:cytoskeletonsq ~ zK t *C:integral to mitochondrial outer membranesq ~ t %C:protein phosphatase type 2A complexsq ~ t C:microsomesq ~ t C:soluble fractionsq ~ y t C:SNARE complexsq ~ v t
C:dendritesq ~ t C:extracellular regionsq ~ t C:replication forksq ~ t C:intracellular organellesq ~ } t 0C:mitochondrial permeability transition pore ...sq ~ ~ t #C:mitochondrial intermembrane spacesq ~ ? t C:nuclear matrixsq ~ t C:endoplasmic reticulum membranesq ~ > t
C:membranesq ~ | t C:nuclear membranepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t 0P:negative regulation of survival gene produc...t 8634sq ~ t 0P:regulation of mitochondrial membrane permea...t 46902sq ~ t 0P:regulation of mitochondrial membrane potentialt 51881sq ~ t +P:release of cytochrome c from mitochondriat 1836sq ~ t F:identical protein bindingt 42802sq ~ t C:mitochondrial outer membranet 5741ppppxsq ~ uq ~
sq ~ t IPR013279t
Apop_reg_BclXsq ~ t IPR012238t
Bcl2_apop_regsq ~ t IPR002475t
BCL2_apoptsissq ~ t IPR000712t Bcl2_BHsq ~ t IPR003093t Bcl2_BH4sq ~ t IPR004725t Bcl2_regppppxsq ~ uq ~
sq ~ t Bcl-2t PF00452sq ~ t BH4t PF02180ppppppppxt Q07817t
BCLX_HUMANsq ~ uq ~
sq ~ t Bcl-2-like 1 proteinpppppppppxt Homo sapienst BBC3sq ~?AA
'
%t Bcl-2-binding component 3sq ~ uq ~
sq ~ 't ENSG00000105327pppppppppxsq ~ uq ~
sq ~ ' t BBC3sq ~ ' t PUMAppppppppxsq ~ ^uq ~
sq ~ ' t P:anti-apoptosissq ~ 6 ' t 0P:regulation of mitochondrial membrane permea...sq ~ , ' t +P:release of cytochrome c from mitochondriasq ~ ! ' t %P:caspase activation via cytochrome csq ~ % ' t P:response to toxinsq ~ ʩ ' t 0P:regulation of mitochondrial membrane potentialsq ~ k ' t &P:multicellular organismal developmentsq ~ ! ' t 0P:negative regulation of survival gene produc...sq ~ ' t *P:regulation of protein heterodimerizationsq ~ ' t (P:regulation of protein homodimerizationsq ~ M
' t P:cellular homeostasissq ~ & ' t P:response to glucose stimulussq ~ '7 ' t P:response to iron ionsq ~ $b ' t P:response to radiationsq ~ ! ' t P:apoptotic programsq ~ ! ' t 0P:induction of apoptosis by intracellular sig...sq ~ ! ' t 0P:induction of apoptosis by extracellular sig...sq ~ !` ' t P:epidermis developmentsq ~ ( ' t 0P:establishment and/or maintenance of transme...sq ~ \ ' t +P:positive regulation of cell proliferationsq ~ [ ' t P:cell proliferationsq ~ ' t P:protein localizationsq ~ v8 ' t (P:nuclear fragmentation during apoptosissq ~ vd ' t $P:negative regulation of cell growthsq ~ P ' t .P:negative regulation of cellular pH reductionsq ~ ' t P:neuron apoptosissq ~ > ' t P:protein tetramerizationsq ~ < ' t P:protein homooligomerizationsq ~ Ǚ ' t *P:negative regulation of helicase activitysq ~ 3 ' t 0P:negative regulation of lipid catabolic processsq ~ < ' t 0P:negative regulation of lipoprotein metaboli...sq ~ R ' t ,P:induction of retinal programmed cell deathsq ~ h ' t 0P:positive regulation of interleukin-8 biosyn...sq ~ ' t .P:mitochondrial fragmentation during apoptosissq ~ ' t )P:positive regulation of neuron apoptosissq ~ 9 ' t "P:positive regulation of apoptosissq ~ ' t 0P:DNA damage response, signal transduction by...sq ~ ' t )P:cellular response to glucose starvationsq ~ ' t P:neutrophil activationsq ~ ' t P:response to nicotinesq ~ ' t -P:release of matrix enzymes from mitochondriasq ~ ɗ ' t P:defense response to virussq ~ u ' t P:mitochondrial fusionsq ~ ' t $P:DNA fragmentation during apoptosissq ~ ' t ,P:regulation of transcription, DNA-dependentsq ~ ' t P:cell fate determinationsq ~ ' t P:nucleotide-excision repairsq ~ ' t P:base-excision repairsq ~ ' t P:B cell apoptosissq ~ ' t #P:regulation of cytokine productionsq ~ ʾ ' t 0P:negative regulation of mitochondrial depola...sq ~ v ' t P:glucose metabolic processsq ~ ' t P:lipid transportsq ~
' t P:cleavage of laminsq ~ J ' t .P:regulation of progression through cell cyclesq ~ ' t P:cell agingsq ~ ' t P:female pregnancysq ~ s ' t P:spermatogenesissq ~ ' t P:cell cycle arrestsq ~ G ' t P:ER overload responsesq ~ / ' t P:humoral immune responsesq ~ ' t P:transformed cell apoptosissq ~ ' t %F:protein heterodimerization activitysq ~ ' t F:protein bindingsq ~ 3 ' t #F:protein homodimerization activitysq ~ t ' t F:transcription factor activitysq ~ ' t F:BH3 domain bindingsq ~ ' t F:copper ion bindingsq ~ ; ' t F:protein channel activitysq ~ } ' t F:protein N-terminus bindingsq ~ ' t F:nuclease activitysq ~ ' t F:lipid transporter activitysq ~ ' t F:protease bindingsq ~ a ' t F:lipid bindingsq ~ Q ' t F:microtubule bindingsq ~ ' t F:DNA strand annealing activitysq ~ N ' t F:zinc ion bindingsq ~ ' t
F:ATP bindingsq ~ 2 ' t F:identical protein bindingsq ~ M ' t F:enzyme bindingsq ~ m ' t C:mitochondrial outer membranesq ~ ' t C:extracellular regionsq ~ ' t C:endoplasmic reticulum membranesq ~ | ' t C:nuclear membranesq ~ } ' t 0C:mitochondrial permeability transition pore ...sq ~ k ' t C:mitochondrionsq ~ i ' t C:cytoplasmsq ~ b ' t C:nucleolussq ~ ' t
C:nucleoplasmsq ~ ' t C:nucleussq ~ ' t C:insoluble fractionsq ~ ' t C:intracellularsq ~ ? ' t C:nuclear matrixsq ~ ' t C:cytosolppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ ' t P:caspase activationt 6919sq ~ ' t P:induction of apoptosist 6917sq ~ ' t P:negative regulation of growtht 45926sq ~ ' t +P:release of cytochrome c from mitochondriat 1836sq ~ ' t F:protein bindingt 5515sq ~ ' t C:mitochondriont 5739ppppxsq ~ uq ~
sq ~ 't IPR000712t Bcl2_BHpppppppppxpt Q9BXH1t
BBC3_HUMANsq ~ uq ~
sq ~ 't 'p53 up-regulated modulator of apoptosissq ~ 't JFY-1ppppppppxt Homo sapienst SHLB1sq ~?Et]E h
%t
Endophilin-B1sq ~ uq ~
sq ~ ht ENSG00000097033pppppppppxsq ~ uq ~
sq ~ h t SH3GLB1sq ~ h t KIAA0491sq ~ h t CGI-61pppppppxsq ~ Huq ~
Psq ~ h t P:induction of apoptosissq ~ h t (P:regulation of protein homodimerizationsq ~ h t *P:regulation of protein heterodimerizationsq ~ h t )P:positive regulation of neuron apoptosissq ~ ! h t 0P:induction of apoptosis by extracellular sig...sq ~ ! h t 0P:negative regulation of survival gene produc...sq ~ h t
P:endocytosissq ~ ! h t 0P:induction of apoptosis by intracellular sig...sq ~ ! h t %P:caspase activation via cytochrome csq ~ [ h t P:cell proliferationsq ~ < h t P:protein homooligomerizationsq ~ u h t P:mitochondrial fusionsq ~ h t
P:behaviorsq ~ q h t P:germ cell developmentsq ~ d h t P:synaptic transmissionsq ~ ! h t !P:apoptotic mitochondrial changessq ~ $ h t P:pathogenesissq ~ i h t P:synaptic vesicle transportsq ~ h h t P:synaptic vesicle endocytosissq ~ R h t ,P:induction of retinal programmed cell deathsq ~ h t P:regulation of transcriptionsq ~ 9 h t "P:positive regulation of apoptosissq ~ h t -P:release of matrix enzymes from mitochondriasq ~ v8 h t (P:nuclear fragmentation during apoptosissq ~ ʩ h t 0P:regulation of mitochondrial membrane potentialsq ~ ( h t 0P:establishment and/or maintenance of transme...sq ~ & h t P:organ morphogenesissq ~ % h t P:response to toxinsq ~ c h t P:cell-cell signalingsq ~ K h t P:protein kinase cascadesq ~ h t P:signal transductionsq ~ h t .P:mitochondrial fragmentation during apoptosissq ~ , h t +P:release of cytochrome c from mitochondriasq ~ h t P:B cell apoptosissq ~ V h t 'P:G2/M transition of mitotic cell cyclesq ~ J h t .P:regulation of progression through cell cyclesq ~ h t P:phosphate metabolic processsq ~ h t P:cell-matrix adhesionsq ~ h t P:caspase activationsq ~ h t $P:DNA fragmentation during apoptosissq ~
h t P:cleavage of laminsq ~ h t P:transformed cell apoptosissq ~ h t F:protein bindingsq ~ B h t F:SH3 domain bindingsq ~ h t %F:protein heterodimerization activitysq ~ - h t F:metallopeptidase activitysq ~ Q h t F:microtubule bindingsq ~ 3 h t #F:protein homodimerization activitysq ~ T h t F:GTPase activitysq ~ h t $F:transcription corepressor activitysq ~ h t F:BH3 domain bindingsq ~ ] h t /F:inositol-polyphosphate 5-phosphatase activitysq ~ : h t F:integrin bindingsq ~ M h t F:enzyme bindingsq ~ _ h t F:transporter activitysq ~ h t
F:GTP bindingsq ~ a h t F:lipid bindingsq ~ M h t F:protein kinase bindingsq ~ @ h t "F:transcription activator activitysq ~ i h t C:cytoplasmsq ~ =
h t C:actin cytoskeletonsq ~ h t C:cytosolsq ~ > h t C:integral to membranesq ~ U h t C:synaptic vesiclesq ~ h t C:integral to plasma membranesq ~ h t C:Golgi apparatussq ~ h t C:endoplasmic reticulum membranesq ~ } h t 0C:mitochondrial permeability transition pore ...sq ~ h t C:soluble fractionsq ~ h t C:postsynaptic membranesq ~ h t C:nucleussq ~ k h t C:mitochondrionppppppppxsq ~ uq ~
sq ~ h t P:anti-apoptosist 6916sq ~ h t #F:protein homodimerization activityt 42803sq ~ h t C:cytoplasmt 5737pppppppxsq ~ uq ~
sq ~ ht IPR004148t BARsq ~ ht IPR001452t SH3ppppppppxsq ~ uq ~
sq ~ ht BARt PF03114sq ~ ht SH3_1t PF00018ppppppppxt Q9Y371t SHLB1_HUMANsq ~ uq ~
sq ~ ht *SH3 domain-containing GRB2-like protein B1sq ~ ht Bax-interacting factor 1sq ~ ht Bif-1pppppppxt Homo sapienst BCL2sq ~?7l4ȕ a b %t Apoptosis regulator Bcl-2sq ~ uq ~
sq ~ t ENSG00000171791pppppppppxsq ~ uq ~
sq ~ t BCL2pppppppppxsq ~ Euq ~
sq ~ t P:induction of apoptosissq ~ t P:anti-apoptosissq ~ , t +P:release of cytochrome c from mitochondriasq ~ t P:caspase activationsq ~ ! t 0P:negative regulation of survival gene produc...sq ~ J t .P:regulation of progression through cell cyclesq ~ t P:signal transductionsq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ ! t %P:caspase activation via cytochrome csq ~ D t $P:protein amino acid phosphorylationsq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ t $P:DNA fragmentation during apoptosissq ~ t P:apoptosissq ~ ! t P:apoptotic programsq ~ & t P:response to stresssq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ F t &P:protein amino acid dephosphorylationsq ~ t (P:regulation of protein homodimerizationsq ~ s t P:spermatogenesissq ~ t 0P:cell surface receptor linked signal transdu...sq ~ t P:nervous system developmentsq ~ K t P:protein kinase cascadesq ~ t *P:regulation of protein heterodimerizationsq ~ t P:cellular iron ion homeostasissq ~ 9 t "P:positive regulation of apoptosissq ~ t P:neuron apoptosissq ~ t P:chemotaxissq ~ v8 t (P:nuclear fragmentation during apoptosissq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ vd t $P:negative regulation of cell growthsq ~ u t P:mitochondrial fusionsq ~ k t &P:multicellular organismal developmentsq ~ \ t +P:positive regulation of cell proliferationsq ~ [ t P:cell proliferationsq ~ t P:cellular respirationsq ~ % t P:response to toxinsq ~ t P:DNA repairsq ~ t P:cell agingsq ~ t P:regulation of DNA replicationsq ~ : t "P:negative regulation of apoptosissq ~ < t P:protein homooligomerizationsq ~ ɗ t P:defense response to virussq ~ t -P:cell structure disassembly during apoptosissq ~ t P:regulation of mitosissq ~ l t
P:proteolysissq ~ t )P:positive regulation of neuron apoptosissq ~ t P:cell cycle arrestsq ~ t P:cell motilitysq ~ t )P:negative regulation of neuron apoptosissq ~ 9 t P:protein foldingsq ~ ] t +P:negative regulation of cell proliferationsq ~ !` t P:epidermis developmentsq ~ t P:RNA splicingsq ~ ! t 0P:induction of apoptosis via death domain rec...sq ~ I t P:regulation of growth ratesq ~ $ t P:response to UVsq ~ $ t P:response to heatsq ~ Y t 0P:chromosome organization and biogenesis (sen...sq ~ $! t P:protein lipoylationsq ~ ! t !P:apoptotic mitochondrial changessq ~ _ t 0P:inner mitochondrial membrane organization a...sq ~ ` t 0P:outer mitochondrial membrane organization a...sq ~ u t 0P:endoplasmic reticulum organization and biog...sq ~ a t !P:Ras protein signal transductionsq ~ t P:chromosome segregationsq ~ d t P:synaptic transmissionsq ~ Z t P:JUN phosphorylationsq ~ q t P:germ cell developmentsq ~ ] t P:glutathione metabolic processsq ~ | t P:female gamete generationsq ~ J t !P:intracellular signaling cascadesq ~ t P:embryo implantationsq ~ 4 t P:Notch receptor processingsq ~ t P:cell adhesionsq ~ t 0P:traversing start control point of mitotic c...sq ~ t P:sensory perception of soundsq ~ t P:locomotory behaviorsq ~ t P:blood pressure regulationsq ~ t P:protein localizationsq ~ % t P:response to woundingsq ~ t &P:relaxation of vascular smooth musclesq ~ t 0P:negative regulation of progression through ...sq ~ t $P:regulation of cell differentiationsq ~ t /P:positive regulation of T cell differentiationsq ~ t /P:positive regulation of B cell differentiationsq ~ t 0P:negative regulation of cholesterol biosynth...sq ~ t P:response to ethanolsq ~ t #P:protein import into mitochondrionsq ~ t 0P:regulation of phosphoprotein phosphatase ac...sq ~ t .P:mitochondrial fragmentation during apoptosissq ~ | t P:muscle maintenancesq ~ C t P:response to dsRNAsq ~ t P:regulation of caspase activitysq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~
t +P:negative regulation of membrane potentialsq ~ f t P:negative regulation of growthsq ~ t 0P:neurofilament cytoskeleton organization and...sq ~ t P:heart contractionsq ~ k t P:Sertoli cell proliferationsq ~ > t P:protein tetramerizationsq ~ Ǚ t *P:negative regulation of helicase activitysq ~ t 0P:positive regulation of interleukin-1 beta s...sq ~ t (P:hydrogen peroxide biosynthetic processsq ~ & t P:response to axon injurysq ~ t P:thymus developmentsq ~ t 0P:negative regulation of fibroblast prolifera...sq ~ R t ,P:induction of retinal programmed cell deathsq ~ J t $P:retinal cell programmed cell deathsq ~ t P:regulation of organ sizesq ~ M t (P:positive regulation of enzyme activitysq ~ t -P:amyloid precursor protein catabolic processsq ~ t P:regulation of apoptosissq ~ w5 t 'P:negative regulation of axon extensionsq ~ v6 t P:apoptotic nuclear changessq ~ u t P:regulation of cell adhesionsq ~ u t .P:regulation of Wnt receptor signaling pathwaysq ~ N t 'P:negative regulation of anti-apoptosissq ~ M t %P:second-messenger-mediated signalingsq ~ M
t P:cellular homeostasissq ~ K t P:removal of superoxide radicalssq ~ K t 0P:cytokine and chemokine mediated signaling p...sq ~ @e t P:protein processingsq ~ @a t &P:negative regulation of transcriptionsq ~ ? t 'P:endoplasmic reticulum membrane fusionsq ~ '1 t P:response to organic substancesq ~ w t P:leukocyte chemotaxissq ~ t 0P:auditory receptor cell stereocilium organiz...sq ~ t 0P:DNA damage response, signal transduction by...sq ~ a t P:glucose homeostasissq ~ . t P:response to hydrogen peroxidesq ~ t 0P:negative regulation of tyrosine phosphoryla...sq ~ t P:response to drugsq ~ U t P:regulation of phosphorylationsq ~ t )P:cellular response to glucose starvationsq ~ N t P:regulation of body sizesq ~ t 0P:negative regulation of protein amino acid d...sq ~ t 0P:positive regulation of protein amino acid d...sq ~ 9 t 0P:regulation of T cell differentiation in the...sq ~ t -P:release of matrix enzymes from mitochondriasq ~ ~ t 0P:myelin maintenance in the peripheral nervou...sq ~ & t P:organ morphogenesissq ~ J t P:response to unfolded proteinsq ~ g t P:retinal homeostasissq ~ / t P:response to superoxidesq ~ t P:spliceosome assemblysq ~ t P:inactivation of MAPK activitysq ~ t P:activation of MAPK activitysq ~ t P:cell fate determinationsq ~ V t 'P:G2/M transition of mitotic cell cyclesq ~ O t 0P:regulation of cyclin-dependent protein kina...sq ~ M t P:DNA damage checkpointsq ~ L t P:DNA replication checkpointsq ~ t P:response to hypoxiasq ~ t )P:nuclear mRNA 3'-splice site recognitionsq ~ b t P:placenta developmentsq ~ 4 t 0P:protein insertion into mitochondrial membra...sq ~ t ,P:positive regulation of cytokine productionsq ~ t P:B cell apoptosissq ~ t "P:T cell homeostatic proliferationsq ~ 6 t "P:B cell homeostatic proliferationsq ~ t P:myeloid cell homeostasissq ~ t P:ovarian follicle developmentsq ~ t P:regulation of transcriptionsq ~ w t P:glucose catabolic processsq ~ t P:base-excision repairsq ~ t P:nucleotide-excision repairsq ~ t P:ceramide metabolic processsq ~ t 0P:oxygen and reactive oxygen species metaboli...sq ~ t P:transportsq ~ t P:calcium ion transportsq ~
t P:cleavage of laminsq ~ t P:virus-infected cell apoptosissq ~ t P:transformed cell apoptosissq ~ + t P:immune responsesq ~ 8 t P:cellular defense responsesq ~ > t !P:response to DNA damage stimulussq ~ G t P:ER overload responsesq ~ t P:fatty acid beta-oxidationsq ~ t $P:protein targeting to mitochondrionsq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t /P:transcription from RNA polymerase II promotersq ~ m t )P:membrane protein ectodomain proteolysissq ~ t P:chromatin remodelingsq ~ G t %P:protein amino acid ADP-ribosylationsq ~ t 0P:regulation of transcription from RNA polyme...sq ~ t P:double-strand break repairsq ~ t P:mRNA catabolic processsq ~ * t F:protein bindingsq ~ t %F:protein heterodimerization activitysq ~ 3 t #F:protein homodimerization activitysq ~ 2 t F:identical protein bindingsq ~ t
F:ATP bindingsq ~ ] t
F:DNA bindingsq ~ t F:calcium ion bindingsq ~ t %F:receptor signaling protein activitysq ~ w t F:caspase activitysq ~ t t F:transcription factor activitysq ~ t F:copper ion bindingsq ~ T t F:GTPase activitysq ~ M t F:enzyme bindingsq ~ c t F:MAP kinase activitysq ~ @ t F:protein kinase activitysq ~ NJ t F:unfolded protein bindingsq ~ ! t 0F:protein phosphatase type 2A regulator activitysq ~ N t F:zinc ion bindingsq ~ t F:BH3 domain bindingsq ~ t F:MP kinase activitysq ~ ! t F:caspase activator activitysq ~ t F:SH3/SH2 adaptor activitysq ~ d t F:MAP kinase kinase activitysq ~ J t F:histone deacetylase bindingsq ~ Ǐ t F:chaperone bindingsq ~ t F:death receptor bindingsq ~ t F:receptor bindingsq ~ t %F:protein phosphatase type 1 activitysq ~ i t "F:protein-tyrosine kinase activitysq ~ r t /F:protein serine/threonine phosphatase activitysq ~ s t 0F:calcium-dependent protein serine/threonine ...sq ~ t F:GTPase activator activitysq ~ t .F:serine-type endopeptidase inhibitor activitysq ~ t F:signal transducer activitysq ~ t ,F:ligand-dependent nuclear receptor activitysq ~ t (F:transmembrane-ephrin receptor activitysq ~ }Z t F:Pyrin domain bindingsq ~ t F:protein phosphatase 2A bindingsq ~ a t F:JUN kinase activitysq ~ R t F:viral receptor activitysq ~ t F:receptor antagonist activitysq ~ t F:catalytic activitysq ~ t
F:RNA bindingsq ~ c t 0F:electron transporter, transferring electron...sq ~ t $F:transcription corepressor activitysq ~ S t (F:cAMP-dependent protein kinase activitysq ~ v t 0F:RNA polymerase II transcription factor acti...sq ~ n t &F:NAD+ ADP-ribosyltransferase activitysq ~ t +F:carnitine O-palmitoyltransferase activitysq ~ Y t F:protein kinase C activitysq ~ s t F:NF-kappaB bindingsq ~ U t *F:cyclin-dependent protein kinase activitysq ~ t F:DNA strand annealing activitysq ~ B t *F:protein serine/threonine kinase activitysq ~ t F:S100 alpha bindingsq ~ t F:nuclease activitysq ~ O t F:endopeptidase activitysq ~ } t F:protein N-terminus bindingsq ~ t F:calmodulin inhibitor activitysq ~ u t (F:Hsp70/Hsc70 protein regulator activitysq ~ t 0F:protein tyrosine phosphatase activator acti...sq ~ t F:lamin bindingsq ~ NE t F:heme bindingsq ~ t
F:GTP bindingsq ~ M t F:protein kinase bindingsq ~ a t F:lipid bindingsq ~ B t F:SH3 domain bindingsq ~ @ t "F:transcription repressor activitysq ~ : t 0F:calcium ion transmembrane transporter activitysq ~ ; t F:protein channel activitysq ~ t F:3'-5' exonuclease activitysq ~ t
C:membranesq ~ t %C:protein phosphatase type 2A complexsq ~ t C:soluble fractionsq ~ t C:endoplasmic reticulum membranesq ~ b t C:nucleolussq ~ t
C:nucleoplasmsq ~ C t C:calcineurin complexsq ~ t C:insoluble fractionsq ~ @K t C:myosin complexsq ~ t C:Golgi apparatussq ~ u t ,C:integral to endoplasmic reticulum membranesq ~ t
C:kinetochoresq ~ ~ t #C:mitochondrial intermembrane spacesq ~ @ t 'C:cAMP-dependent protein kinase complexsq ~ t C:plasma membranesq ~ t C:mitochondrial matrixsq ~ t C:cytoskeletonsq ~ W t !C:perinuclear region of cytoplasmsq ~ t
C:ribosomesq ~ t C:peroxisomesq ~ t C:microsomesq ~ } t 0C:mitochondrial permeability transition pore ...sq ~ n t 0C:mitochondrial outer membrane translocase co...sq ~ t C:protein complexsq ~ t C:intracellular organellesq ~ t C:cell somasq ~ G t C:dendrite cytoplasmsq ~ v t
C:dendritesq ~ y$ t C:extracellular matrixsq ~ y t C:SNARE complexsq ~ y t C:intrinsic to membranesq ~ zK t *C:integral to mitochondrial outer membranesq ~ z t C:cytoplasmic vesiclesq ~ t C:extracellular regionsq ~ t C:extracellular spacesq ~ R t C:pore complexsq ~ 1 t
C:spliceosomesq ~ t $C:integral to nuclear inner membranesq ~ : t C:Cajal bodysq ~ = t C:microtubule cytoskeletonsq ~ > t C:integral to membranesq ~ t C:cytosolic partsq ~ ? t C:nuclear matrixsq ~ @ t C:sarcoplasmic reticulumsq ~ t C:intracellularsq ~ | t C:mitochondrial membranepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
(sq ~ t P:response to toxint 9636sq ~ t P:neuron apoptosist 51402sq ~ t 0P:regulation of mitochondrial membrane permea...t 46902sq ~ t .P:regulation of progression through cell cyclet 74sq ~ t *P:regulation of protein heterodimerizationt 43497sq ~ t (P:regulation of protein homodimerizationt 43496sq ~ t +P:release of cytochrome c from mitochondriat 1836sq ~ t P:response to iron iont 10039sq ~ t P:response to nicotinet 35094sq ~ t P:response to radiationt 9314sq ~ t 0P:negative regulation of mitochondrial depola...t 51902sq ~ t .P:negative regulation of cellular pH reductiont 32848sq ~ t P:humoral immune responset 6959sq ~ t P:female pregnancyt 7565sq ~ t P:defense response to virust 51607sq ~ t P:anti-apoptosist 6916sq ~ t F:BH3 domain bindingt 51434sq ~ t F:protease bindingt 2020sq ~ t %F:protein heterodimerization activityt 46982sq ~ t #F:protein homodimerization activityt 42803sq ~ t C:nuclear membranet 31965sq ~ t C:mitochondrial outer membranet 5741ppppppppppppppppppxsq ~ uq ~
sq ~ t IPR013278t
Apop_reg_Bcl2sq ~ t IPR012238t
Bcl2_apop_regsq ~ t IPR002475t
BCL2_apoptsissq ~ t IPR000712t Bcl2_BHsq ~ t IPR003093t Bcl2_BH4sq ~ t IPR004725t Bcl2_regppppxsq ~ uq ~
sq ~ t Bcl-2t PF00452sq ~ t BH4t PF02180ppppppppxt P10415t
BCL2_HUMANpt Homo sapienst ERN1sq ~?q q
K, %t ?Serine/threonine-protein kinase/endoribonuclease IRE1 precursorsq ~ uq ~
sq ~ K,t ENSG00000178607pppppppppxsq ~ uq ~
sq ~ K, t ERN1sq ~ K, t IRE1ppppppppxsq ~ Xuq ~
sq ~ ( K, t 0P:establishment and/or maintenance of transme...sq ~ ʩ K, t 0P:regulation of mitochondrial membrane potentialsq ~ ! K, t 0P:induction of apoptosis by extracellular sig...sq ~ K, t (P:regulation of protein homodimerizationsq ~ K, t *P:regulation of protein heterodimerizationsq ~ , K, t +P:release of cytochrome c from mitochondriasq ~ K, t P:anti-apoptosissq ~ K, t P:chromosome segregationsq ~ % K, t P:response to toxinsq ~ ! K, t %P:caspase activation via cytochrome csq ~ ! K, t 0P:negative regulation of survival gene produc...sq ~ J K, t P:response to unfolded proteinsq ~ ! K, t 0P:induction of apoptosis by intracellular sig...sq ~ u K, t P:mitochondrial fusionsq ~ Y K, t 0P:chromosome organization and biogenesis (sen...sq ~ Y K, t P:activation of JNK activitysq ~ R K, t )P:activation of NF-kappaB-inducing kinasesq ~ 4 K, t P:Notch receptor processingsq ~ K, t P:signal transductionsq ~ < K, t P:protein homooligomerizationsq ~ @e K, t P:protein processingsq ~ v8 K, t (P:nuclear fragmentation during apoptosissq ~ ƶ K, t *P:positive regulation of T cell activationsq ~ 6 K, t 0P:regulation of mitochondrial membrane permea...sq ~ K, t (P:protein amino acid autophosphorylationsq ~ R K, t ,P:induction of retinal programmed cell deathsq ~ K, t $P:negative regulation of JNK cascadesq ~ u K, t 0P:positive regulation of nitric oxide biosynt...sq ~ K, t .P:mitochondrial fragmentation during apoptosissq ~ K, t )P:positive regulation of neuron apoptosissq ~ K, t )P:negative regulation of caspase activitysq ~ M K, t (P:positive regulation of enzyme activitysq ~ K, t -P:amyloid precursor protein catabolic processsq ~ U K, t P:regulation of phosphorylationsq ~ * K, t P:protein refoldingsq ~ K, t -P:release of matrix enzymes from mitochondriasq ~ K, t P:transformed cell apoptosissq ~
K, t P:cleavage of laminsq ~ K, t $P:positive regulation of JNK cascadesq ~
K, t 0P:positive regulation of T cell cytokine prod...sq ~ K, t P:B cell apoptosissq ~ K, t $P:DNA fragmentation during apoptosissq ~ K, t /P:transcription from RNA polymerase II promotersq ~ K, t
P:translationsq ~ = K, t P:protein complex assemblysq ~ m K, t )P:membrane protein ectodomain proteolysissq ~ K, t P:mitochondrial transportsq ~ K, t P:induction of apoptosissq ~ K, t
F:ATP bindingsq ~ 3 K, t #F:protein homodimerization activitysq ~ K, t F:protein bindingsq ~ K, t %F:protein heterodimerization activitysq ~ K, t (F:translation initiation factor activitysq ~ K, t #F:protein kinase inhibitor activitysq ~ K, t F:caspase inhibitor activitysq ~ e K, t #F:MAP kinase kinase kinase activitysq ~ B K, t *F:protein serine/threonine kinase activitysq ~ 2 K, t F:identical protein bindingsq ~ O K, t F:endopeptidase activitysq ~ K, t F:signal transducer activitysq ~ K, t $F:transcription coactivator activitysq ~ x K, t F:TPR domain bindingsq ~ w K, t F:protein binding, bridgingsq ~ a K, t F:lipid bindingsq ~ v K, t *F:nitric-oxide synthase regulator activitysq ~ ! K, t F:caspase activator activitysq ~ NJ K, t F:unfolded protein bindingsq ~ K, t F:magnesium ion bindingsq ~ K, t F:BH3 domain bindingsq ~ K, t F:calcium ion bindingsq ~ K, t C:cytosolsq ~ k K, t C:mitochondrionsq ~ u K, t ,C:integral to endoplasmic reticulum membranesq ~ ' K, t C:cell surfacesq ~ K, t C:endoplasmic reticulum lumensq ~ K, t C:endoplasmic reticulumsq ~ K, t
C:kinetochoresq ~ W K, t !C:perinuclear region of cytoplasmsq ~ K, t $C:integral to nuclear inner membranesq ~ R K, t C:pore complexsq ~ K, t C:integral to plasma membranesq ~ } K, t 0C:mitochondrial permeability transition pore ...sq ~ K, t #C:ER-Golgi intermediate compartmentsq ~ K, t 0C:eukaryotic translation initiation factor 3 ...sq ~ K, t C:nucleussq ~ K, t C:membrane fractionsq ~ K, t C:Golgi apparatussq ~ K, t C:endoplasmic reticulum membraneppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~
uq ~
sq ~ K, t 0P:unfolded protein response, activation of si...t 6987sq ~ K, t $P:protein amino acid phosphorylationt 6468sq ~ K, t P:induction of apoptosist 6917sq ~ K, t P:cell cycle arrestt 7050sq ~ K, t *F:protein serine/threonine kinase activityt 4674sq ~ K, t F:protein bindingt 5515sq ~ K, t F:magnesium ion bindingt 287sq ~ K, t F:endoribonuclease activityt 4521sq ~ K, t
F:ATP bindingt 5524sq ~ K, t ,C:integral to endoplasmic reticulum membranet 30176xsq ~ uq ~
sq ~ K,t IPR002372t
PQQ_repeatsq ~ K,t IPR000719t Prot_kinase_coresq ~ K,t IPR006567t PUGsq ~ K,t IPR010513t RNase_Lsq ~ K,t IPR008271t Ser_thr_pkin_ASpppppxsq ~ uq ~
sq ~ K,t Pkinaset PF00069sq ~ K,t PQQt PF01011sq ~ K,t Ribonuc_2-5At PF06479pppppppxt O75460t
ERN1_HUMANsq ~ uq ~
sq ~ K,t Inositol-requiring protein 1sq ~ K,t hIRE1psq ~ K,t IRE1asq ~ K,t
Ire1-alphasq ~ K,t ,Endoplasmic reticulum-to-nucleus signaling 1sq ~ K,t Serine/threonine-protein kinasesq ~ K,t Endoribonucleasepppxt Homo sapienst BIMsq ~?KK &b %t Bcl-2-like protein 11sq ~ uq ~
sq ~ &bt ENSG00000153094pppppppppxsq ~ uq ~
sq ~ &b t BCL2L11sq ~ &b t BIMppppppppxsq ~ Yuq ~
sq ~ &b t P:anti-apoptosissq ~ , &b t +P:release of cytochrome c from mitochondriasq ~ V &b t
P:JNK cascadesq ~ & &b t P:response to stresssq ~ ! &b t P:apoptotic programsq ~ &b t (P:regulation of protein homodimerizationsq ~ &b t *P:regulation of protein heterodimerizationsq ~ 6 &b t 0P:regulation of mitochondrial membrane permea...sq ~ &b t P:visual behaviorsq ~ & &b t P:organ morphogenesissq ~ % &b t $P:anatomical structure morphogenesissq ~ % &b t P:response to toxinsq ~ $b &b t P:response to radiationsq ~ $ &b t P:response to UVsq ~ $ &b t P:response to heatsq ~ k &b t &P:multicellular organismal developmentsq ~ ! &b t 0P:negative regulation of survival gene produc...sq ~ s &b t P:spermatogenesissq ~ ^ &b t $P:insulin receptor signaling pathwaysq ~ | &b t P:female gamete generationsq ~ &b t P:female pregnancysq ~ '7 &b t P:response to iron ionsq ~ F &b t !P:peptidyl-serine phosphorylationsq ~ M
&b t P:cellular homeostasissq ~ &b t P:neuron apoptosissq ~ &b t 0P:insulin-like growth factor receptor signali...sq ~ ʩ &b t 0P:regulation of mitochondrial membrane potentialsq ~ &b t (P:protein amino acid autophosphorylationsq ~ &b t )P:positive regulation of neuron apoptosissq ~ B &b t P:response to exogenous dsRNAsq ~ : &b t "P:negative regulation of apoptosissq ~ &b t P:response to nicotinesq ~ P &b t .P:negative regulation of cellular pH reductionsq ~ ~ &b t P:response to lipopolysaccharidesq ~ ʾ &b t 0P:negative regulation of mitochondrial depola...sq ~ { &b t /P:lipopolysaccharide-mediated signaling pathwaysq ~ vd &b t $P:negative regulation of cell growthsq ~ u &b t P:regulation of cell adhesionsq ~ uT &b t 0P:actin cytoskeleton organization and biogenesissq ~ M &b t P:cytosine metabolic processsq ~ ɗ &b t P:defense response to virussq ~ Z &b t P:JUN phosphorylationsq ~ J &b t !P:intracellular signaling cascadesq ~ &b t P:cell fate determinationsq ~ &b t P:MAPKKK cascadesq ~ J &b t .P:regulation of progression through cell cyclesq ~ < &b t ,P:protein import into nucleus, translocationsq ~ D &b t $P:protein amino acid phosphorylationsq ~ &b t #P:nitric oxide biosynthetic processsq ~ &b t P:anion transportsq ~ &b t P:induction of apoptosissq ~ &b t P:caspase activationsq ~ &b t P:activated T cell apoptosissq ~ &b t -P:negative regulation of cell differentiationsq ~ &b t 0P:G-protein coupled receptor protein signalin...sq ~ &b t P:signal transductionsq ~ j &b t P:microtubule-based movementsq ~ b &b t *P:cytoskeleton organization and biogenesissq ~ > &b t !P:response to DNA damage stimulussq ~ / &b t P:humoral immune responsesq ~ &b t P:cell motilitysq ~
&b t F:protein bindingsq ~ a &b t F:JUN kinase activitysq ~ &b t %F:protein heterodimerization activitysq ~ 2 &b t F:identical protein bindingsq ~ 3 &b t #F:protein homodimerization activitysq ~ &b t F:protease bindingsq ~ &b t F:phosphotyrosine bindingsq ~ &b t F:motor activitysq ~ &b t F:microtubule motor activitysq ~ B &b t *F:protein serine/threonine kinase activitysq ~ &b t F:BH3 domain bindingsq ~ c &b t F:MAP kinase activitysq ~ d &b t F:MAP kinase kinase activitysq ~ &b t F:Rho GTPase activator activitysq ~ &b t
F:ATP bindingsq ~ &b t
F:GTP bindingsq ~ Y< &b t &F:voltage-gated anion channel activitysq ~ ; &b t F:protein channel activitysq ~ i &b t C:cytoplasmsq ~ m &b t C:mitochondrial outer membranesq ~ &b t C:cytoplasmic dynein complexsq ~ &b t C:plasma membranesq ~ &b t C:cytosolsq ~ W &b t !C:perinuclear region of cytoplasmsq ~ k &b t C:mitochondrionsq ~ R &b t C:pore complexsq ~ &b t C:nucleussq ~ | &b t C:nuclear membranepppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppppxsq ~ uq ~
sq ~ &b t P:induction of apoptosist 6917sq ~ &b t F:protein bindingt 5515sq ~ &b t C:membrane fractiont 5624pppppppxsq ~ uq ~
sq ~ &bt IPR014771t Apoptosis_Bim_Nsq ~ &bt IPR000712t Bcl2_BHsq ~ &bt IPR015040t
Bclx_interactpppppppxsq ~ uq ~
sq ~ &bt
Bclx_interactt PF08945sq ~ &bt Bim_Nt PF06773ppppppppxt O43521t BIM_HUMANsq ~ uq ~
sq ~ &bt 'Bcl2-interacting mediator of cell deathpppppppppxt Homo sapienst B2L10sq ~?II
%t Apoptosis regulator Bcl-Bsq ~ uq ~
sq ~ t ENSG00000137875pppppppppxsq ~ uq ~
sq ~ t BCL2L10sq ~ t BCLBppppppppxsq ~ >uq ~
Psq ~ t (P:regulation of protein homodimerizationsq ~ t *P:regulation of protein heterodimerizationsq ~ , t +P:release of cytochrome c from mitochondriasq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ t P:induction of apoptosissq ~ ! t %P:caspase activation via cytochrome csq ~ ! t 0P:negative regulation of survival gene produc...sq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ % t P:response to toxinsq ~ t )P:positive regulation of neuron apoptosissq ~ t P:anti-apoptosissq ~ '7 t P:response to iron ionsq ~ $b t P:response to radiationsq ~ ! t !P:apoptotic mitochondrial changessq ~ v8 t (P:nuclear fragmentation during apoptosissq ~ w t P:leukocyte chemotaxissq ~ P t .P:negative regulation of cellular pH reductionsq ~ ɗ t P:defense response to virussq ~ t P:neuron apoptosissq ~ < t P:protein homooligomerizationsq ~ ʾ t 0P:negative regulation of mitochondrial depola...sq ~ R t ,P:induction of retinal programmed cell deathsq ~ t .P:mitochondrial fragmentation during apoptosissq ~ t P:response to nicotinesq ~ t -P:release of matrix enzymes from mitochondriasq ~ ! t P:apoptotic programsq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ t P:caspase activationsq ~ t $P:DNA fragmentation during apoptosissq ~ J t .P:regulation of progression through cell cyclesq ~
t P:cleavage of laminsq ~ t P:transformed cell apoptosissq ~ / t P:humoral immune responsesq ~ q t P:germ cell developmentsq ~ t P:nervous system developmentsq ~ t P:female pregnancysq ~ u t P:mitochondrial fusionsq ~ t P:B cell apoptosissq ~ t P:cellular iron ion homeostasissq ~ t %F:protein heterodimerization activitysq ~ t F:protein bindingsq ~ 3 t #F:protein homodimerization activitysq ~ 2 t F:identical protein bindingsq ~ t F:BH3 domain bindingsq ~ t F:nucleotide bindingsq ~ a t F:lipid bindingsq ~ t F:protease bindingsq ~ o t F:enzyme activator activitysq ~ ! t F:caspase activator activitysq ~ w t F:caspase activitysq ~ t F:receptor antagonist activitysq ~ m t C:mitochondrial outer membranesq ~ k t C:mitochondrionsq ~ t C:cytosolsq ~ | t C:nuclear membranesq ~ t C:endoplasmic reticulum membranesq ~ } t 0C:mitochondrial permeability transition pore ...sq ~ W t !C:perinuclear region of cytoplasmsq ~ t C:extracellular regionsq ~ R t C:pore complexppppppppppppppppppxsq ~ uq ~
sq ~ t P:anti-apoptosist 6916sq ~ t P:caspase activationt 6919sq ~ t P:female gamete generationt 7292sq ~ t P:spermatogenesist 7283sq ~ t F:protein bindingt 5515sq ~ t C:cytosolt 5829sq ~ t C:membrane fractiont 5624sq ~ t C:mitochondriont 5739ppxsq ~ uq ~
sq ~ t IPR012238t
Bcl2_apop_regsq ~ t IPR002475t
BCL2_apoptsissq ~ t IPR000712t Bcl2_BHpppppppxsq ~ uq ~
sq ~ t Bcl-2t PF00452pppppppppxt Q9HD36t B2L10_HUMANsq ~ uq ~
sq ~ t Bcl-2-like 10 proteinsq ~ t Bcl2-L-10sq ~ t Anti-apoptotic protein NrHpppppppxt Homo sapienst 1433Tsq ~?xycݯ %t 14-3-3 protein thetasq ~ uq ~
sq ~ t ENSG00000134308pppppppppxsq ~ uq ~
sq ~ t YWHAQpppppppppxsq ~ %uq ~
@sq ~
t P:signal transductionsq ~ D t $P:protein amino acid phosphorylationsq ~ J t .P:regulation of progression through cell cyclesq ~ [ t P:cell proliferationsq ~ t P:mRNA splice site selectionsq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t 0P:cell surface receptor linked signal transdu...sq ~ t 0P:G-protein coupled receptor protein signalin...sq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ \ t +P:positive regulation of cell proliferationsq ~ t P:cell adhesionsq ~ t
P:endocytosissq ~ ] t +P:negative regulation of cell proliferationsq ~ !` t P:epidermis developmentsq ~ t $P:DNA fragmentation during apoptosissq ~ J t P:response to unfolded proteinsq ~ ! t 0P:negative regulation of survival gene produc...sq ~ U t 0P:regulation of G-protein coupled receptor pr...sq ~ t P:anti-apoptosissq ~ J t !P:intracellular signaling cascadesq ~ uT t 0P:actin cytoskeleton organization and biogenesissq ~ >x t P:proton transportsq ~ ] t P:muscle developmentsq ~ C t P:response to oxidative stresssq ~ t P:potassium ion transportsq ~ t P:muscle contractionsq ~ * t P:inflammatory responsesq ~ , t +P:release of cytochrome c from mitochondriasq ~ E t 0P:negative regulation of protein kinase activitysq ~ t P:cell motilitysq ~ t P:activation of MAPK activitysq ~ t P:MAPKKK cascadesq ~ t P:apoptosissq ~ t P:mitosissq ~
t P:cleavage of laminsq ~ | t P:female gamete generationsq ~ t P:single fertilizationsq ~ O t
P:circulationsq ~ t P:response to nutrientsq ~ t P:chemotaxissq ~ t P:respiratory gaseous exchangesq ~ t P:visual perceptionsq ~ t P:long-term memorysq ~ t 0P:epidermal growth factor receptor signaling ...sq ~ t P:endosome to lysosome transportsq ~ ^ t $P:insulin receptor signaling pathwaysq ~ u t P:mitochondrial fusionsq ~ s t P:spermatogenesissq ~ q t P:germ cell developmentsq ~ t P:regulation of mitosissq ~ t P:mRNA export from nucleussq ~ t P:cell cycle arrestsq ~ t P:cell cyclesq ~ r t 0P:negative regulation of microtubule depolyme...sq ~ T t 'P:organelle organization and biogenesissq ~ i t P:microtubule-based processsq ~ ʶ t 0P:positive regulation of focal adhesion forma...sq ~ 8 t P:cellular defense responsesq ~ t P:transformed cell apoptosissq ~ d t P:synaptic transmissionsq ~ c t P:cell-cell signalingsq ~ ` t +P:small GTPase mediated signal transductionsq ~ Y t P:activation of JNK activitysq ~ K t P:protein kinase cascadesq ~ t P:membrane fusionsq ~ ( t P:defense responsesq ~ t 0P:regulation of epidermal growth factor recep...sq ~ g t P:actin filament organizationsq ~ ! t P:female gonad developmentsq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ ` t &P:regulation of neuron differentiationsq ~ t P:regulation of transcriptionsq ~ t 0P:establishment and/or maintenance of epithel...sq ~ 5 t $P:intermediate filament organizationsq ~ t 0P:regulation of phosphoprotein phosphatase ac...sq ~ D t P:skin developmentsq ~ t )P:positive regulation of neuron apoptosissq ~ t *P:regulation of protein heterodimerizationsq ~ t (P:regulation of protein homodimerizationsq ~ t )P:negative regulation of caspase activitysq ~ s t 0P:positive regulation of I-kappaB kinase/NF-k...sq ~ : t "P:negative regulation of apoptosissq ~ t P:regulation of angiogenesissq ~ t P:positive regulation of mitosissq ~ t 0P:negative regulation of striated muscle deve...sq ~ $ t &P:regulation of stress fiber formationsq ~ < t P:protein homooligomerizationsq ~ t P:regulation of mRNA processingsq ~ t 0P:positive regulation of receptor mediated en...sq ~ ' t #P:regulation of synaptic plasticitysq ~ t 0P:negative regulation of nuclear mRNA splicin...sq ~ t %P:vesicle transport along microtubulesq ~ [ t P:nucleotide phosphorylationsq ~ t (P:protein amino acid autophosphorylationsq ~ R t ,P:induction of retinal programmed cell deathsq ~ u t &P:positive regulation of transcriptionsq ~ E t 0P:positive regulation of transcription, DNA-d...sq ~ t 0P:Golgi to plasma membrane CFTR protein trans...sq ~ t .P:DNA damage response, detection of DNA damagesq ~ t P:fibrinolysissq ~ > t
P:cell growthsq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ & t #P:regulation of signal transductionsq ~ & t P:organ morphogenesissq ~ % t $P:anatomical structure morphogenesissq ~ % t P:response to toxinsq ~ % t P:response to virussq ~ $b t P:response to radiationsq ~ ! t !P:apoptotic mitochondrial changessq ~ ! t %P:caspase activation via cytochrome csq ~ ! t P:apoptotic programsq ~ ! t 0P:DNA damage response, signal transduction re...sq ~ ? t P:phosphorylationsq ~ ? t P:dephosphorylationsq ~ @b t P:cytoplasmic transportsq ~ t !P:peptidyl-arginine N-methylationsq ~ t -P:release of matrix enzymes from mitochondriasq ~ d t P:response to insulin stimulussq ~ ^ t P:activation of Rho GTPasesq ~ } t .P:negative regulation of TOR signaling pathwaysq ~ w9 t %P:androgen receptor signaling pathwaysq ~ vd t $P:negative regulation of cell growthsq ~ v8 t (P:nuclear fragmentation during apoptosissq ~ u t P:B cell differentiationsq ~ u t P:protein catabolic processsq ~ B t 0P:negative regulation of protein biosynthetic...sq ~ @ t P:protein ubiquitinationsq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ t P:induction of apoptosissq ~ t P:receptor-mediated endocytosissq ~ p t P:fructose metabolic processsq ~ t .P:mitochondrial fragmentation during apoptosissq ~ O t 0P:regulation of cyclin-dependent protein kina...sq ~ t P:cell morphogenesissq ~ z t 0P:negative regulation of transcription from R...sq ~ t P:mitotic spindle elongationsq ~ t P:inactivation of MAPK activitysq ~ K t 'P:complement activation, lectin pathwaysq ~ t P:B cell apoptosissq ~ t $P:assembly of spliceosomal tri-snRNPsq ~ t P:regulation of cell growthsq ~ t 0P:nucleotide-excision repair, DNA damage removalsq ~ v t P:glucose metabolic processsq ~ u t P:DNA-dependent DNA replicationsq ~ t P:chromatin silencingsq ~ t (P:ER to Golgi vesicle-mediated transportsq ~ t P:chloride transportsq ~ t P:calcium ion transportsq ~ t P:sodium ion transportsq ~ t +P:phosphatidylinositol biosynthetic processsq ~ t P:lipid metabolic processsq ~ l t
P:proteolysissq ~ t P:telomere maintenancesq ~ t /P:transcription from RNA polymerase II promotersq ~ 9 t P:protein foldingsq ~ t
P:translationsq ~ t P:mRNA catabolic processsq ~ t P:rRNA export from nucleussq ~ = t F:protein bindingsq ~ t F:GTPase activator activitysq ~ t F:signal transducer activitysq ~ t
F:ATP bindingsq ~ ? t *F:1-phosphatidylinositol-3-kinase activitysq ~ B t *F:protein serine/threonine kinase activitysq ~ @ t F:protein kinase activitysq ~ P t (F:structural constituent of cytoskeletonsq ~ t t F:transcription factor activitysq ~ 3 t #F:protein homodimerization activitysq ~ t F:microtubule motor activitysq ~ t $F:transcription coactivator activitysq ~ NJ t F:unfolded protein bindingsq ~ t %F:protein kinase C inhibitor activitysq ~ t F:calcium ion bindingsq ~ t F:potassium channel activitysq ~ 2 t F:identical protein bindingsq ~ ' t -F:insulin-like growth factor receptor bindingsq ~ t
F:RNA bindingsq ~ } t F:protein N-terminus bindingsq ~ Q t F:microtubule bindingsq ~ e t #F:MAP kinase kinase kinase activitysq ~ t F:magnesium ion bindingsq ~ y t 0F:RNA splicing factor activity, transesterifi...sq ~ t %F:protein heterodimerization activitysq ~ I t F:casein kinase I activitysq ~ D t 0F:3-phosphoinositide-dependent protein kinase...sq ~ e t &F:cysteine-type endopeptidase activitysq ~ t F:telomeric DNA bindingsq ~ w t 0F:Rac guanyl-nucleotide exchange factor activitysq ~ \ t $F:atypical protein kinase C activitysq ~ i t "F:protein-tyrosine kinase activitysq ~ K t F:nucleotide kinase activitysq ~ M t F:enzyme bindingsq ~ M t F:interleukin-1 bindingsq ~ N t F:diacylglycerol bindingsq ~ t 0F:cyclin-dependent protein kinase inhibitor a...sq ~ t &F:ubiquitin-specific protease activitysq ~ t F:androgen receptor bindingsq ~ t #F:ubiquitin-protein ligase activitysq ~ u t 'F:protein tyrosine phosphatase activitysq ~ t F:ATPase activity, coupledsq ~ t .F:caspase-activated deoxyribonuclease activitysq ~ f t 0F:calcium-dependent cysteine-type endopeptida...sq ~ ] t
F:DNA bindingsq ~ d t F:damaged DNA bindingsq ~ ! t #F:6-phosphofructo-2-kinase activitysq ~ j t F:double-stranded DNA bindingsq ~ t $F:structural constituent of ribosomesq ~ - t F:RS domain bindingsq ~ t F:RNA helicase activitysq ~ ! t F:guanylate kinase activitysq ~ 7 t F:histone deacetylase activitysq ~ Ǐ t F:chaperone bindingsq ~ t F:BH3 domain bindingsq ~ t F:endonuclease activitysq ~ t F:Rap GTPase activator activitysq ~ D t 0F:ATP-dependent polydeoxyribonucleotide 5'-hy...sq ~ C t (F:polynucleotide 3'-phosphatase activitysq ~ t F:Rac GTPase bindingsq ~ N t *F:1-phosphatidylinositol 4-kinase activitysq ~ t F:phosphoprotein bindingsq ~ t 0F:telomeric template RNA reverse transcriptas...sq ~ t (F:protein phosphatase inhibitor activitysq ~ t F:transcription factor bindingsq ~ t 0F:transforming growth factor beta receptor, c...sq ~ t F:protein kinase C bindingsq ~ t 0F:Ras guanyl-nucleotide exchange factor activitysq ~ & t F:insulin receptor bindingsq ~ ! t F:caspase activator activitysq ~ _ t F:transporter activitysq ~ t F:chloride channel activitysq ~ t
F:GTP bindingsq ~ t F:sugar bindingsq ~ t F:phospholipid bindingsq ~ t F:phosphatidylinositol bindingsq ~ a t F:lipid bindingsq ~ V t F:protein C-terminus bindingsq ~ t F:methyltransferase activitysq ~ : t /F:sodium ion transmembrane transporter activitysq ~ : t 0F:calcium ion transmembrane transporter activitysq ~ t 0F:transmembrane receptor protein tyrosine kin...sq ~ @ t "F:transcription repressor activitysq ~ @ t -F:specific transcriptional repressor activitysq ~ @ t "F:transcription activator activitysq ~ t F:receptor activitysq ~ c t 0F:follicle-stimulating hormone receptor activitysq ~ t 0F:macrophage colony stimulating factor recept...sq ~ ? t F:kinase activitysq ~ ? t +F:regulator of G-protein signaling activitysq ~ t F:SH3/SH2 adaptor activitysq ~ t C:nucleussq ~ i t C:cytoplasmsq ~ t C:plasma membranesq ~ t C:cytosolsq ~ t C:integral to plasma membranesq ~ > t
C:membranesq ~ t C:kinesin complexsq ~ t C:intracellularsq ~ t C:endoplasmic reticulumsq ~ t C:protein complexsq ~ t
C:endosomesq ~ t
C:microtubulesq ~ o t C:mitochondrial inner membranesq ~ > t C:integral to membranesq ~ m t C:mitochondrial outer membranesq ~ k t C:mitochondrionsq ~ t C:endoplasmic reticulum membranesq ~ t C:intercellular junctionsq ~ t C:membrane fractionsq ~ t
C:spectrinsq ~ 2 t
C:cell cortexsq ~ W t !C:perinuclear region of cytoplasmsq ~ v t C:histone deacetylase complexsq ~ t C:spindlesq ~ t C:intermediate filamentsq ~ = t C:microtubule cytoskeletonsq ~ t 0C:cytosolic large ribosomal subunit (sensu Eu...sq ~ t C:Golgi apparatussq ~ ' t C:cell surfacesq ~ uK t C:lamellipodiumsq ~ t C:early endosomesq ~ ' t C:keratin filamentsq ~ M t
C:synaptosomesq ~ t C:extracellular spacesq ~ t C:nuclear envelopesq ~ q t C:integrin complexsq ~ # t C:transcription factor complexsq ~ A t C:telomerase holoenzyme complexsq ~ =
t C:actin cytoskeletonsq ~ t
C:nucleoplasmsq ~
t C:chromosome, telomeric regionsq ~ } t 0C:mitochondrial permeability transition pore ...sq ~ t C:soluble fractionsq ~ 6 t #C:phosphoinositide 3-kinase complexpppppppppppppppppppppppppppxsq ~ uq ~
sq ~ t F:protein bindingt 5515pppppppppxsq ~ uq ~
sq ~ t IPR000308t 14-3-3pppppppppxsq ~ uq ~
sq ~ t 14-3-3t PF00244pppppppppxt P27348t 1433T_HUMANsq ~ uq ~
sq ~ t 14-3-3 protein tausq ~ t 14-3-3 protein T-cellsq ~ t Protein HS1pppppppxt Homo sapienst 1433Ssq ~?B %t 14-3-3 protein sigmasq ~ uq ~
sq ~ t ENSG00000175793pppppppppxsq ~ uq ~
sq ~ t SFNsq ~ t HME1ppppppppxsq ~ Xuq ~
sq ~ D t $P:protein amino acid phosphorylationsq ~ t P:signal transductionsq ~ J t .P:regulation of progression through cell cyclesq ~ ] t +P:negative regulation of cell proliferationsq ~ [ t P:cell proliferationsq ~ * t P:inflammatory responsesq ~ = t P:protein complex assemblysq ~ t P:cell adhesionsq ~ t P:nervous system developmentsq ~ &> t P:embryonic developmentsq ~ uT t 0P:actin cytoskeleton organization and biogenesissq ~ t
P:endocytosissq ~ t ,P:regulation of transcription, DNA-dependentsq ~ t P:anti-apoptosissq ~ Y t P:activation of JNK activitysq ~ t 0P:negative regulation of striated muscle deve...sq ~ t 0P:epidermal growth factor receptor signaling ...sq ~ t P:cell cycle arrestsq ~ u t P:B cell differentiationsq ~ vd t $P:negative regulation of cell growthsq ~ t P:RNA processingsq ~ ` t +P:small GTPase mediated signal transductionsq ~ t P:mRNA export from nucleussq ~ @ t P:protein ubiquitinationsq ~ \ t +P:positive regulation of cell proliferationsq ~ ^ t $P:insulin receptor signaling pathwaysq ~ v t 'P:positive regulation of cell migrationsq ~ t )P:positive regulation of neuron apoptosissq ~ t *P:regulation of protein heterodimerizationsq ~ t (P:regulation of protein homodimerizationsq ~ t &P:positive regulation of MAPK activitysq ~ @ t P:chromatin modificationsq ~ F t #P:peptidyl-tyrosine phosphorylationsq ~ ? t P:cell-cell adhesionsq ~ {, t #P:actin cytoskeleton reorganizationsq ~ ! t %P:caspase activation via cytochrome csq ~ ! t 0P:induction of apoptosis by extracellular sig...sq ~ M t P:DNA damage checkpointsq ~ t 0P:positive regulation of epithelial cell prol...sq ~ t P:induction of apoptosissq ~ t P:cell cyclesq ~ t P:regulation of cell growthsq ~ t 0P:G-protein coupled receptor protein signalin...sq ~ t P:cell morphogenesissq ~ t P:cell motilitysq ~ & t P:response to stresssq ~ ` t &P:regulation of neuron differentiationsq ~ ' t #P:regulation of synaptic plasticitysq ~ t P:potassium ion transportsq ~ t !P:intracellular protein transportsq ~ t P:apoptosissq ~ & t P:organ morphogenesissq ~ F t &P:protein amino acid dephosphorylationsq ~ t (P:protein amino acid autophosphorylationsq ~ K t P:protein kinase cascadesq ~ t 0P:cell surface receptor linked signal transdu...sq ~ t 0P:establishment and/or maintenance of cell po...sq ~ % t P:protein kinase C activationsq ~ d t P:synaptic transmissionsq ~ t P:meiotic recombinationsq ~ t P:asymmetric cell divisionsq ~ ! t 0P:negative regulation of survival gene produc...sq ~ ! t P:apoptotic programsq ~ ! t 0P:DNA damage response, signal transduction re...sq ~ ! t 0P:induction of apoptosis by intracellular sig...sq ~ t 'P:cytokinesis, initiation of separationsq ~ t P:visual perceptionsq ~ !` t P:epidermis developmentsq ~ t P:RNA splicingsq ~ k t &P:multicellular organismal developmentsq ~ t (P:negative regulation of DNA replicationsq ~ V t
P:JNK cascadesq ~ t 0P:G-protein signaling, coupled to cGMP nucleo...sq ~ l t P:gamete generationsq ~ s t P:spermatogenesissq ~ t P:single fertilizationsq ~ t P:pattern specification processsq ~ = t %P:integrin-mediated signaling pathwaysq ~ t P:neuroblast proliferationsq ~ t P:axonogenesissq ~ S t P:heart developmentsq ~ t P:cell agingsq ~ t P:excretionsq ~ " t P:phospholipase C activationsq ~ u t P:mitochondrial fusionsq ~ t 0P:transmembrane receptor protein tyrosine kin...sq ~ t P:protein localizationsq ~ t P:cell communicationsq ~ t 0P:regulation of attachment of spindle microtu...sq ~ t %P:phosphoinositide-mediated signalingsq ~ t 0P:nerve growth factor receptor signaling pathwaysq ~ t 0P:insulin-like growth factor receptor signali...sq ~ t 0P:platelet-derived growth factor receptor sig...sq ~ t %P:vesicle transport along microtubulesq ~ 6 t 0P:regulation of mitochondrial membrane permea...sq ~ ~ t P:entry of virus into host cellsq ~ R t ,P:induction of retinal programmed cell deathsq ~ u t &P:positive regulation of transcriptionsq ~ t $P:positive regulation of endocytosissq ~ t P:regulation of angiogenesissq ~ t 0P:positive regulation of protein biosynthetic...sq ~ t 0P:Wnt receptor signaling pathway through beta...sq ~ t P:regulation of transcriptionsq ~ t 0P:negative regulation of nuclear mRNA splicin...sq ~ * t 0P:regulation of peptidyl-tyrosine phosphoryla...sq ~ ʸ t 0P:regulation of protein kinase B signaling ca...sq ~ ʩ t 0P:regulation of mitochondrial membrane potentialsq ~ e t P:cell divisionsq ~ > t P:protein tetramerizationsq ~ < t P:protein homooligomerizationsq ~ t !P:protein insertion into membranesq ~ Ǚ t *P:negative regulation of helicase activitysq ~ p t 0P:regulation of small GTPase mediated signal ...sq ~ I t !P:actin filament bundle formationsq ~ 7 t .P:regulation of nitric-oxide synthase activitysq ~ ƥ t #P:B cell receptor signaling pathwaysq ~ Ƥ t #P:T cell receptor signaling pathwaysq ~ ƅ t P:protein stabilizationsq ~ V t /P:negative regulation of dendrite morphogenesissq ~ u t 0P:positive regulation of nitric oxide biosynt...sq ~ t 0P:establishment and/or maintenance of epithel...sq ~ x t P:mammary gland developmentsq ~ v8 t (P:nuclear fragmentation during apoptosissq ~ v t P:keratinocyte differentiationsq ~ u t P:water homeostasissq ~ @b t P:cytoplasmic transportsq ~ c t #P:keratan sulfate metabolic processsq ~ ?b t P:iron-sulfur cluster assemblysq ~ ( t 0P:establishment and/or maintenance of transme...sq ~ '6 t P:response to metal ionsq ~ & t #P:regulation of signal transductionsq ~ t P:sodium ion transportsq ~ % t $P:anatomical structure morphogenesissq ~ % t P:response to toxinsq ~ $ t P:nitrogen fixationsq ~ t -P:release of matrix enzymes from mitochondriasq ~ t )P:cellular response to glucose starvationsq ~ x t P:apical protein localizationsq ~ t P:G0 to G1 transitionsq ~ t .P:mitochondrial fragmentation during apoptosissq ~ t P:cellular pigment accumulationsq ~ : t "P:negative regulation of apoptosissq ~ 9 t "P:positive regulation of apoptosissq ~ t /P:calcium-dependent phospholipase A2 activationsq ~ t 0P:Golgi to plasma membrane CFTR protein trans...sq ~ t P:regulation of apoptosissq ~ t +P:glucocorticoid receptor signaling pathwaysq ~ t 0P:DNA damage response, signal transduction by...sq ~ W t (P:positive regulation of phosphorylationsq ~ t 0P:negative regulation of protein catabolic pr...sq ~ t )P:regulation of protein catabolic processsq ~ $b t P:response to radiationsq ~ t 0P:negative regulation of cyclin-dependent pro...sq ~ O t 0P:regulation of cyclin-dependent protein kina...sq ~ X t "P:polysaccharide metabolic processsq ~ v t P:glucose metabolic processsq ~ | t P:galactose metabolic processsq ~ t P:base-excision repairsq ~ t P:nucleotide-excision repairsq ~ t P:mismatch repairsq ~ t $P:DNA fragmentation during apoptosissq ~ s t 0P:S-phase-specific transcription in mitotic c...sq ~ z t 0P:negative regulation of transcription from R...sq ~ t P:mitotic spindle elongationsq ~ a t P:liver developmentsq ~ , t +P:release of cytochrome c from mitochondriasq ~ t P:B cell apoptosissq ~ t P:ossificationsq ~ t )P:cytokinesis, contractile ring formationsq ~ t $P:assembly of spliceosomal tri-snRNPsq ~ t P:activation of MAPKK activitysq ~ t P:chromatin silencingsq ~ t /P:transcription from RNA polymerase II promotersq ~ t P:transformed cell apoptosissq ~ ( t P:defense responsesq ~ > t !P:response to DNA damage stimulussq ~ G t P:ER overload responsesq ~ b t *P:cytoskeleton organization and biogenesissq ~ g t P:actin filament organizationsq ~ r t 0P:negative regulation of microtubule depolyme...sq ~ t P:mitosissq ~
t P:cleavage of laminsq ~ t P:caspase activationsq ~ t P:receptor-mediated endocytosissq ~ t P:RNA catabolic processsq ~ t P:mRNA catabolic processsq ~ E t 0P:negative regulation of protein kinase activitysq ~ o t /P:ubiquitin-dependent protein catabolic processsq ~ t +P:phosphatidylinositol biosynthetic processsq ~ 9 t "P:glucocorticoid catabolic processsq ~ t !P:cellular sodium ion homeostasissq ~ t P:mRNA splice site selectionsq ~ 4 t F:protein bindingsq ~ t
F:ATP bindingsq ~ B t *F:protein serine/threonine kinase activitysq ~ t F:magnesium ion bindingsq ~ 3 t #F:protein homodimerization activitysq ~ t %F:protein heterodimerization activitysq ~ 2 t F:identical protein bindingsq ~ @ t F:protein kinase activitysq ~ t F:GTPase activator activitysq ~ t F:signal transducer activitysq ~ t F:actin bindingsq ~ t
F:RNA bindingsq ~ t F:transcription factor bindingsq ~ t #F:ubiquitin-protein ligase activitysq ~ ] t
F:DNA bindingsq ~ u t 'F:protein tyrosine phosphatase activitysq ~ ' t -F:insulin-like growth factor receptor bindingsq ~ k t 0F:non-membrane spanning protein tyrosine kina...sq ~ t t F:transcription factor activitysq ~ 7 t F:histone deacetylase activitysq ~ Q t F:microtubule bindingsq ~ t ,F:guanyl-nucleotide exchange factor activitysq ~ @ t "F:transcription activator activitysq ~ t F:microtubule motor activitysq ~ j t F:double-stranded DNA bindingsq ~ @ t -F:specific transcriptional repressor activitysq ~ t
F:GTP bindingsq ~ i t "F:protein-tyrosine kinase activitysq ~ M t F:protein kinase bindingsq ~ e t #F:MAP kinase kinase kinase activitysq ~ t +F:epidermal growth factor receptor activitysq ~ } t F:protein N-terminus bindingsq ~ t F:potassium channel activitysq ~ V t F:protein C-terminus bindingsq ~ N t F:zinc ion bindingsq ~ t F:SH3/SH2 adaptor activitysq ~ G t F:actin filament bindingsq ~ f t F:MAP/ERK kinase kinase activitysq ~ t 0F:transmembrane receptor protein tyrosine kin...sq ~ l t 0F:receptor signaling protein tyrosine kinase ...sq ~ t F:protein kinase C bindingsq ~ u t F:ErbB-3 class receptor bindingsq ~ t %F:receptor signaling protein activitysq ~ t 0F:macrophage colony stimulating factor recept...sq ~ t F:Rho GTPase activator activitysq ~ t "F:glucocorticoid receptor activitysq ~ s t "F:structural constituent of musclesq ~ t F:gamma-tubulin bindingsq ~ t F:alpha-tubulin bindingsq ~ t &F:ubiquitin-specific protease activitysq ~ t #F:phosphoinositide 3-kinase bindingsq ~ e t F:protein self-associationsq ~ U t *F:cyclin-dependent protein kinase activitysq ~ t #F:calcium-dependent protein bindingsq ~ t $F:transcription coactivator activitysq ~ t F:BH3 domain bindingsq ~ t F:S100 beta bindingsq ~ g t F:beta-tubulin bindingsq ~ - t F:RS domain bindingsq ~ t F:DNA strand annealing activitysq ~ NJ t F:unfolded protein bindingsq ~ M t F:beta-catenin bindingsq ~ t F:single-stranded RNA bindingsq ~ t F:mRNA bindingsq ~ t F:motor activitysq ~ a t F:lipid bindingsq ~ J t #F:keratan sulfotransferase activitysq ~ t F:nuclease activitysq ~ W t )F:phosphoinositide 5-phosphatase activitysq ~ N t *F:1-phosphatidylinositol 4-kinase activitysq ~ T t F:GTPase activitysq ~ J t F:protein kinase CK2 activitysq ~ ! t F:guanylate kinase activitysq ~ e t &F:cysteine-type endopeptidase activitysq ~ t %F:protein phosphatase type 1 activitysq ~ t F:SH2 domain bindingsq ~ & t F:insulin receptor bindingsq ~ N t F:structural molecule activitysq ~ P t (F:structural constituent of cytoskeletonsq ~ t %F:protein kinase C inhibitor activitysq ~ u t F:manganese ion bindingsq ~ Bx t F:Ras GTPase bindingsq ~ B t #F:sodium channel regulator activitysq ~ t F:iron ion bindingsq ~ t F:copper ion bindingsq ~ M t !F:protein domain specific bindingsq ~ v t F:translation repressor activitysq ~ ! t 'F:protein kinase CK2 regulator activitysq ~ @ t "F:transcription repressor activitysq ~ t !F:glucocorticoid receptor bindingsq ~ t 0F:phosphatidylinositol-4-phosphate 3-kinase a...sq ~ t 0F:ARF guanyl-nucleotide exchange factor activitysq ~ M t F:protein phosphatase bindingsq ~ ! t F:caspase activator activitysq ~ t F:cytoskeletal adaptor activitysq ~ y t 0F:RNA splicing factor activity, transesterifi...sq ~ M t F:enzyme bindingsq ~ i t C:cytoplasmsq ~ t C:nucleussq ~ t C:plasma membranesq ~ t C:cytosolsq ~ t C:intracellularsq ~ t C:kinesin complexsq ~ t C:membrane fractionsq ~ > t C:integral to membranesq ~ k t C:mitochondrionsq ~ v t C:histone deacetylase complexsq ~ t
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t P:cellular homeostasissq ~ t P:response to nicotinesq ~ '7 t P:response to iron ionsq ~ & t ,P:negative regulation of signal transductionsq ~ ɗ t P:defense response to virussq ~ t P:signal transductionsq ~ R t ,P:induction of retinal programmed cell deathsq ~ J t .P:regulation of progression through cell cyclesq ~ t P:B cell apoptosissq ~ t P:cell fate determinationsq ~ t $P:DNA fragmentation during apoptosissq ~ t P:skeletal developmentsq ~ t P:mitochondrial transportsq ~ t !P:cellular copper ion homeostasissq ~
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